glucagon has been researched along with glucagon-like peptide 1 in 2071 studies
| Studies (glucagon) | Trials (glucagon) | Recent Studies (post-2010) (glucagon) | Studies (glucagon-like peptide 1) | Trials (glucagon-like peptide 1) | Recent Studies (post-2010) (glucagon-like peptide 1) |
|---|---|---|---|---|---|
| 26,039 | 1,498 | 3,054 | 9,484 | 1,208 | 6,374 |
| Protein | Taxonomy | glucagon (IC50) | glucagon-like peptide 1 (IC50) |
|---|---|---|---|
| Glucagon-like peptide 1 receptor | Homo sapiens (human) | 0.0051 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (2.51) | 18.7374 |
| 1990's | 614 (29.65) | 18.2507 |
| 2000's | 774 (37.37) | 29.6817 |
| 2010's | 453 (21.87) | 24.3611 |
| 2020's | 178 (8.59) | 2.80 |
| Authors | Studies |
|---|---|
| Marks, V | 2 |
| Fehmann, HC; Habener, JF | 3 |
| Göke, B; Göke, R; Oltmer, B; Sheikh, SP | 1 |
| Orskov, C | 1 |
| Brubaker, PL; Drucker, DJ; Lee, YC | 1 |
| Eng, J; Raufman, JP; Singh, G; Singh, L | 1 |
| Habener, JF; Holz, GH; Kuhtreiber, WM | 1 |
| Ahrén, B; Efendic, S; Gutniak, M; Holst, JJ; Orskov, C | 1 |
| Classen, M; Dehne, K; Schepp, W; Schmidtler, J; Schusdziarra, V | 2 |
| Blázquez, E; Toledano, A; Uttenthal, LO | 1 |
| Fujita, C; Noma, Y; Shima, K; Takahashi, J; Yoshimoto, S | 1 |
| Itoh, H; Komatsu, R; Kono, N; Matsumura, T; Matsuyama, T; Matsuzawa, Y; Namba, M; Oda, Y; Tanaka, M; Watanabe, N | 1 |
| Fehmann, HC; Göke, B; Göke, R | 4 |
| Beorlegui, C; Martínez, A; Sesma, P | 1 |
| Holst, JJ; Orskov, C | 3 |
| Bartels, E; Creutzfeldt, W; Ebert, R; Nauck, MA; Orskov, C | 2 |
| Kawai, K; Ohashi, S; Suzuki, S; Watanabe, Y; Yamashita, K | 2 |
| Creutzfeldt, W | 4 |
| Nicod, P; Waeber, G | 1 |
| Arnold, R; Eissele, R; Göke, B; Göke, R; Harthus, HP; Vermeer, H; Willemer, S | 1 |
| Fogel, H; Habener, JF; Mojsov, S; Nathan, DM; Schreiber, E | 1 |
| D'Alessio, DA; Ensinck, JW | 1 |
| Daimon, M; Fukase, N; Igarashi, M; Manaka, H; Sasaki, H; Sugiyama, K; Takahashi, H; Tominaga, M; Yamatani, K | 2 |
| Creutzfeldt, W; Schmidt, WE; Schulze, A; Siegel, EG | 1 |
| Fukuda, M; Hotta, M; Ikegami, H; Morimoto, S; Ogihara, T; Shima, K | 1 |
| Barthel, M; Ebert, R; Köhler, H; Nustede, R; Schafmayer, A; Schröter-Printzen, I | 1 |
| Bloom, SR; Fuller, CR; Ghatei, MA; Lund, PK; Rountree, DB; Selub, S; Ulshen, MH | 1 |
| Blackmore, PF; Exton, JH; Habener, JF; Mojsov, S | 1 |
| Orskov, C; Poulsen, SS | 1 |
| Bloom, SR; Domin, J; Ghatei, MA; Kanse, S; Kreymann, B | 1 |
| Bloom, SR; Efrat, S; Ghatei, MA; Polak, JM; Rindi, G; Solcia, E | 1 |
| Habener, JF; Kopczynski, MG; Mojsov, S | 1 |
| Arnold, R; Fehmann, HC; Göke, B; Göke, R; Richter, G; Trautmann, ME; Weber, V | 1 |
| Arnold, R; Bächle, R; Fehmann, HC; Göke, B; Göke, R; Wagner, B | 1 |
| Yanaihara, N | 1 |
| Classen, M; Fürlinger, C; Janczewska, I; Schepp, W; Schmidtler, J; Schusdziarra, V; Weigert, N | 1 |
| Hisatomi, A; Inoue, K; Nawata, H; Umeda, F | 1 |
| Eguchi, H; Fukase, N; Manaka, H; Sasaki, H; Sekikawa, A; Suda, K; Takahashi, H; Tominaga, M | 1 |
| Faulkner, A | 1 |
| Ahrén, B; Fridolf, T | 3 |
| Kawai, K; Koizumi, F; Ohashi, S; Ohneda, A; Ohneda, K; Ohneda, M; Suzuki, S | 1 |
| Arnold, R; Göke, B; Göke, R; Richter, G; Schmidt, H | 1 |
| Oshima, I; Shima, K; Yamamoto, C | 1 |
| Ahrén, B; Böttcher, G; Fridolf, T; Sundler, F | 1 |
| Holst, JJ; Kotzerke, J; Meyer, HJ; Miholic, J; Orskov, C | 1 |
| Fletcher, J; Marks, V; Morgan, L; Oben, J | 1 |
| Arnold, R; Eissele, R; Koop, H | 1 |
| Holst, JJ; Jeppesen, J; Madsbad, S; Orskov, C | 1 |
| Faulkner, A; Pollock, HT | 1 |
| Alarcón, C; Castilla, C; López-Novoa, JM; Pintado, J; Ruiz-Grande, C; Valverde, I | 1 |
| Ebert, R | 1 |
| Kawai, K; Mukai, H; Murayama, Y; Ohashi, S; Suzuki, S; Yamashita, K | 1 |
| Gefel, D; Habener, J; Hendrick, GK; Mojsov, S; Weir, GC | 1 |
| Blázquez, E; Uttenthal, LO | 1 |
| Arnold, R; Göke, B; Göke, R; Richter, G | 3 |
| Mommsen, TP; Moon, TW | 1 |
| Conlon, JM; Creutzfeldt, W; Gallwitz, B; Schmidt, WE | 1 |
| Kawai, K; Murayama, Y; Ohashi, S; Suzuki, S; Yamashita, K | 1 |
| Cha, T; Hirota, M; Ikegami, H; Noma, Y; Ogihara, T; Ohboshi, C; Tahara, Y; Yamamoto, Y; Yamato, E; Yoneda, H | 1 |
| Aulehner, R; Classen, M; Schmid, R; Schusdziarra, V; Weigert, N | 1 |
| Arnold, R; Fehmann, HC; Göke, B; Göke, R | 2 |
| Kawai, K; Mukai, H; Murayma, Y; Ohashi, S; Suzuki, S; Yamashita, K | 1 |
| Shima, K | 1 |
| Bloom, SR; Ghatei, MA; Kreymann, B; Nikou, GC; O'Halloran, DJ | 1 |
| Cole, T; Conlon, JM; Göke, R | 1 |
| Arnold, R; Fehmann, HC; Göke, B; Göke, R; Haus, E; Richter, G; Trautmann, ME | 1 |
| Arnold, R; Göke, B; Göke, R; Richter, G; Trautmann, M | 1 |
| Kawai, K; Mukai, H; Murayama, Y; Ohashi, S; Ohmori, H; Suzuki, S; Yamashita, K | 1 |
| Fehmann, HC; Göke, B; Göke, R; Richter, G; Trautmann, M | 1 |
| D'Alessio, DA; Ensinck, JW; Fujimoto, WY | 1 |
| Fukase, N; Manaka, H; Sasaki, H; Suda, K; Takahashi, H; Tominaga, M | 1 |
| Habener, JF; Hendrick, GK; Mojsov, S; Weir, GC | 1 |
| Itoh, H; Komatsu, R; Kono, N; Matsuyama, T; Namba, M; Tarui, S; Watanabe, N | 1 |
| Arnold, R; Fehmann, HC; Göke, B; Göke, R; Trautmann, ME | 1 |
| Kawai, K; Mukai, H; Ohashi, S; Suzuki, S; Yamashita, K | 1 |
| Christiansen, J; Holst, JJ; Mortensen, PE; Orskov, C; Schjoldager, BT | 1 |
| Hirota, M; Ohboshi, C; Shima, K; Yoshimoto, S | 1 |
| Bloom, SR; Burnet, P; Diani, AR; Ghatei, MA; Kanse, S; Kreymann, B; Williams, G | 1 |
| Nielsen, JH; Orskov, C | 1 |
| Conlon, JM; Göke, R | 1 |
| Gespach, CP; Hansen, AB; Holst, JJ; Rosselin, GE | 1 |
| Bloom, SR; Ghatei, MA; Kanse, SM; Kreymann, B | 1 |
| Holst, JJ; Nielsen, OV; Orskov, C | 1 |
| Alvarez, E; Blazquez, E; Bloom, SR; de Diego, JG; George, SK; Ghiglione, M; Uttenthal, LO | 1 |
| Hirota, M; Ohboshi, C; Shima, K; Shimizu, I | 1 |
| Hirota, M; Ohboshi, C; Shima, K | 1 |
| Ginier, P; Levin, SR; Soon-Shiong, P; Swafford, G | 1 |
| Itoh, H; Komatsu, R; Matsuyama, T; Namba, M; Tarui, S; Watanabe, N | 1 |
| Andrews, PC; Mommsen, TP; Plisetskaya, EM | 1 |
| Bloom, SR; Ghatei, MA; Kanse, S; Kreymann, B; Williams, G; Yiangou, Y | 1 |
| Hirota, M; Nishino, T; Ohboshi, C; Shima, K; Shimizu, I | 1 |
| Honda, M; Ikeda, T; Ito, Y; Mashiba, H; Mokuda, O; Tominaga, M; Yoshida, T | 1 |
| Hirota, M; Ohboshi, C; Sato, M; Shima, K | 1 |
| Itoh, H; Komatsu, R; Kono, N; Matsuyama, T; Miyagawa, J; Namba, M; Tarui, S; Watanabe, N | 1 |
| Hirota, M; Ohboshi, C; Oshima, I; Shima, K | 1 |
| Holst, JJ; Kirkegaard, P; Orskov, C; Poulsen, SS | 1 |
| Baldissera, FG; Holst, JJ; Knuhtsen, S; Nielsen, OV; Orskov, C; Poulsen, SS | 1 |
| Habener, JF; Mojsov, S; Weir, GC | 1 |
| Bailey, CJ; Flatt, PR | 1 |
| Creutzfeldt, W; Ebert, R | 2 |
| Hirota, M; Nishino, T; Ohboshi, C; Sato, M; Shima, K | 1 |
| Bishop, AE; Bloom, SR; Polak, JM; Sikri, KL; Uttenthal, LO; Varndell, IM | 1 |
| Gurd, RS; Hoosein, NM | 1 |
| Brown, JC | 1 |
| Björntorp, P | 1 |
| Lauritsen, KB | 1 |
| Creutzfeldt, W; Ebert, R; Unger, H | 1 |
| Akerblom, HK; Knip, M; Kouvalainen, K; Lautala, P; Martin, JM | 1 |
| Bloom, SR; George, SK; Ghiglione, M; Uttenthal, LO | 1 |
| Levy, N; Stermer, E | 1 |
| Christensen, KC; Lauritsen, KB; Lauritzen, JB | 1 |
| Levin, SR | 1 |
| Brandhorst, D; Brandhorst, H; Bretzel, RG; Federlin, K; Fehmann, HC; Göke, B; Hering, BJ; Wolf, MJ | 1 |
| Páv, J | 1 |
| Göke, B; Herrmann-Rinke, C; Hess, M; Vöge, A | 1 |
| Bode, HP; Göke, B; Göke, R; Lankat-Buttgereit, B; van Eyll, B | 1 |
| Adelhorst, K; Hjorth, SA; Kirk, O; Pedersen, BB; Schwartz, TW | 1 |
| Chalt, BT; Zhao, Y | 1 |
| Abrahamsen, N; Nishimura, E | 1 |
| Asa, SL; Brubaker, PL; Drucker, DJ; Jin, T; Young, TA | 1 |
| Habener, JF; Holz, GG; Leech, CA | 2 |
| Deacon, CF; Holst, JJ; Johnsen, AH | 2 |
| Ebner, K; Fürnsinn, C; Waldhäusl, W | 1 |
| Boreham, C; Buchanan, KD; Johnston, CF; O'Connor, AM; Riddoch, CJ; Trinick, TR | 1 |
| Alcántara, A; Clemente, F; Delgado, E; Luque, MA; Perea, A; Trapote, MA; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Fukuzawa, K; Makino, T; Matsumoto, A; Noguchi, Y; Nomura, K; Tsuburaya, A; Yoshikawa, T | 1 |
| Egan, JM; Montrose-Rafizadeh, C; Nadiv, O; Raygada, M; Roth, J; Wang, Y | 1 |
| Chayvialle, JA; Cuber, JC; Dakka, T; Dumoulin, V; Plaisancie, P | 1 |
| Brubaker, PL; Rocca, AS | 2 |
| Ahrén, B; Lindskog, S; Scheurink, AJ; Steffens, AB; van Dijk, G | 1 |
| Bode, HP; Fehmann, HC; Göke, B; Göke, R; Lankat-Buttgereit, B; Volz, A | 1 |
| Dissing, S; Gromada, J; Rorsman, P; Wulff, BS | 1 |
| D'Alessio, DA; Ensinck, JW; Prigeon, RL | 1 |
| Martin, S; Rouillé, Y; Steiner, DF | 1 |
| Creutzfeldt, W; Holst, JJ; Nauck, MA; Orskov, C; Qualmann, C | 2 |
| Hasumi, S; Kawai, K; Kuroki, H; Maruyama, A; Miyazono, Y; Omori, Y; Owada, K; Wasada, T; Yano, K; Yoshino, H | 1 |
| Kieffer, TJ; McIntosh, CH; Pederson, RA | 1 |
| Chayvialle, JA; Cuber, JC; Dumoulin, V; Plaisancié, P | 1 |
| Deacon, CF; Holst, JJ; Nauck, MA; Pridal, L; Toft-Nielsen, M; Willms, B | 1 |
| Hargrove, DM; Nardone, NA; Parker, JC; Persson, LM; Stevenson, RW | 1 |
| Holst, JJ; Nauck, MA; Orskov, C; Ritzel, R | 1 |
| Harling, H; Holst, JJ; Rasmussen, TN; Schmidt, P | 1 |
| Göke, B; Göke, R; McGregor, GP | 1 |
| Bloom, SR; Ghatei, MA; Kruszynska, YT; McIntyre, N | 1 |
| Okuda, Y; Yamashita, K | 1 |
| Goebell, H; Grandt, D; Holst, JJ; Layer, P | 1 |
| Elliott, R; Jia, X; Kwok, YN; McIntosh, CH; Pederson, RA | 1 |
| Brown, JC; Jia, X; Ma, P; McIntosh, CH; Pederson, RA | 1 |
| Langlois, WJ; Olefsky, JM; Pillay, TS | 1 |
| Arnold, R; Fehmann, HC; Göke, B; Göke, R; Herrmann, C; Richter, G | 1 |
| Kawai, K; Ohashi, S; Watanabe, Y; Yamashita, K; Yokota, C | 1 |
| Bridenbaugh, S; Fieseler, P; Holst, JJ; Martell, J; Nauck, MA; Nustede, R; Orskov, C | 1 |
| Amano, N; Koyama, N; Kuriyama, M; Nishimura, O | 1 |
| Bataille, D; Gros, L; Hollande, F; Kervran, A; Thorens, B | 1 |
| Irwin, DM; Wong, J | 1 |
| Ahrén, B | 7 |
| Alcántara, A; Clemente, F; Delgado, E; Galera, C; Luque, MA; Trapote, MA; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Behme, MT; Dupre, J; Hramiak, IM; McDonald, TJ; McFarlane, P; Williamson, MP; Zabel, P | 1 |
| Bokvist, K; Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Renström, E; Rorsman, P; Wulff, BS | 1 |
| Blázquez, E; Calvo, JC; Mora, F; Yusta, B | 1 |
| Eng, J; Raufman, JP; Singh, G | 1 |
| Fehmann, HC; Göke, B; Göke, R; Kolligs, F | 1 |
| Biswas, C; Brady, EJ; Conti, M; Cullinan, CA; Hayes, NS; Leibowitz, MD; Manganiello, VC; Saperstein, R; Wang, LH; Zafian, PT | 1 |
| Abello, J; Bosshard, A; Chayvialle, JA; Saifia, S | 1 |
| Weir, GC | 1 |
| Bloom, SR; Ghatei, MA; Owji, AA; Smith, DM; Wang, RM; Wang, Z | 1 |
| Funakoshi, A; Iwamoto, N; Matsuoka, Y; Shima, K; Tateishi, K; Yasunami, Y | 1 |
| Classen, M; Dehne, K; Eng, J; Holst, JJ; Raufman, JP; Riedel, T; Schepp, W; Schmidtler, J; Schusdziarra, V | 1 |
| Deacon, S; Elliott, RM; Marks, V; Morgan, LM; Tredger, JA; Wright, J | 1 |
| Britsch, S; Drews, G; Gregor, M; Krippeit-Drews, P; Lang, F | 2 |
| Fletcher, JM; Knapper, JM; Morgan, LM; Puddicombe, SM | 1 |
| Alcántara, AI; Clemente, F; Delgado, E; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Brown, JC; Jia, X; Kwok, YN; McIntosh, CH; Pederson, RA | 1 |
| Amiel, SA | 1 |
| Brown, JC; Fell, CD; Huang, Z; Kieffer, TJ; Pedersen, RA; Verchere, CB | 1 |
| Arnold, R; Bothe-Sandfort, E; Eissele, R; Eng, J; Göke, B; Koop, H | 1 |
| Christiansen, J; Holst, JJ; Orskov, C; Petersen, H; Sheikh, SP; Wettergren, A | 1 |
| Boyd, AE; Fehmann, HC; Göke, B; Jiang, J; Schweinfurth, J; Wheeler, MB | 1 |
| Göke, B; Göke, R; Just, R; Lankat-Buttgereit, B | 1 |
| Allescher, HD; Classen, M; Dehne, K; Holst, JJ; Polack, A; Schepp, W; Schmidtler, J; Schusdziarra, V | 1 |
| Bernier, M; Egan, JM; Montrose-Rafizadeh, C; Roth, J; Wang, Y | 1 |
| Eckart, K; Fölsch, UR; Gallwitz, B; Morys-Wortmann, C; Paetzold, G; Schmidt, WE; Witt, M; Zimmermann, B | 1 |
| Holst, JJ | 11 |
| Datta, G; Kim, Y; Liu, Y; Ozaki, Y; Rose, CA; Tu, AT | 1 |
| Efendić, S; Gutniak, MK; Holst, JJ; Linde, B | 1 |
| Bernard, C; Chayvialle, JA; Cuber, JC; Plaisancie, P | 1 |
| Boyd, AE; Dörsch, K; Fehmann, HC; Göke, B; Jiang, J; Schweinfurth, J; Wheeler, MB | 1 |
| Brady, EJ; Cullinan, CA; Leibowitz, MD; Saperstein, R | 1 |
| Egan, JM; Montrose-Rafizadeh, C; Roth, J | 1 |
| Andersen, DK; Elahi, D; Fukagawa, NK; Habener, JF; McAloon-Dyke, M; Meneilly, GS; Minaker, KL; Sclater, AL | 1 |
| Dandrifosse, G; Deloyer, P; Kaouass, M; Sulon, J | 1 |
| Clemente, F; Delgado, E; López-Delgado, MI; Morales, M; Perea, A; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Thorens, B | 4 |
| Arnold, R; Eissele, R; Fehmann, HC; Göke, B; Göke, R; Weichardt, U | 1 |
| Andreasen, JJ; Holst, JJ; Orskov, C | 1 |
| Astrup, A; Christensen, NJ; Holst, JJ; Madsen, J; Raben, A; Tagliabue, A | 1 |
| Gallwitz, B; Mentlein, R; Schmidt, WE | 1 |
| Bataille, D; Gros, L; Kervran, A; Thorens, B | 1 |
| Faulkner, A; Martin, PA | 8 |
| Fehmann, HC; Göke, B | 1 |
| Kato, T; Manaka, H; Sasaki, H; Sugiyama, K; Tominaga, M; Yamatani, K | 1 |
| Fehmann, HC; Göke, B; Göke, R; Jiang, J; Lankat-Buttgereit, B; Stöckmann, F | 1 |
| Alarcón, C; Alcántara, A; Castilla, C; López Novoa, JM; Ruiz-Grande, C; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Adelhorst, K; Hedegaard, BB; Kirk, O; Knudsen, LB | 1 |
| Habener, JF | 1 |
| Holst, JJ; Kofod, H; Orskov, C; Rabenhøj, L; Wettergren, A | 1 |
| Kawai, K; Ohashi, S; Suzuki, S; Watanabe, Y; Yamashita, K; Yokota, C | 1 |
| Gorenstein, DG; Thornton, K | 1 |
| Abello, J; Bernard, C; Bosshard, A; Chayvialle, JA; Cuber, JC; Ye, F | 1 |
| Campos, RV; Drucker, DJ; Lee, YC | 1 |
| Martin, SK; Rouillé, Y; Steiner, DF; Westermark, G | 1 |
| Barragán, JM; Blázquez, E; Rodríguez, RE | 1 |
| D'Alessio, DA; Ensinck, JW; Kahn, SE; Leusner, CR | 1 |
| Bürki, E; Dolci, W; Thorens, B; Widmann, C | 1 |
| Classen, M; Dehne, K; Offermanns, S; Rosenthal, W; Schepp, W; Schmidtler, J | 1 |
| Waeber, G | 1 |
| Borkowski, D; Chicchi, GG; Graziano, MP; Hey, PJ; Strader, CD | 1 |
| Barth, P; Feddersen, O; Göke, B; Göke, R; Richter, G; Wagner, U | 1 |
| Conlon, JM; Mommsen, TP; Youson, JH | 1 |
| Delgado, E; Mérida, E; Molina, LM; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Hilsted, J; Holst, JJ; Hvidberg, A; Nielsen, MT; Orskov, C | 1 |
| Brubaker, PL; Roberge, JN | 1 |
| Holst, JJ; Kotzerke, J; Miholic, J; Orskov, C; Pichlmayr, R | 1 |
| Baartz, A; Baartz, T; Becker, HD; Büsing, M; Creutzfeldt, W; Hopt, UT; Nauck, MA; Orskov, C; Siegel, EG; Talartschik, J | 1 |
| Gregor, M; Hartmann, F; Plauth, M; Raible, A | 1 |
| Thorens, B; Waeber, G | 1 |
| Fletcher, JM; Knapper, JM; Marks, V; Morgan, LM; Puddicombe, SM | 1 |
| Delgado, E; Mérida, E; Trapote, MA; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Boyd, AE; Leng, XH; Lu, M; Wheeler, MB | 1 |
| Habener, JF; Holz, GG; Kühtreiber, WM | 1 |
| Atillasoy, EJ; Burtis, WJ; Gaich, G; Ganz, MB; Orloff, JJ; Stewart, AF | 1 |
| Göke, B; Göke, R; Kolligs, F; Lankat-Buttgereit, B; Richter, G | 1 |
| Fujiyama, K; Hoshino, T; Ikeda, T; Mashiba, H; Ochi, H; Ohtani, I; Takeuchi, T; Tanaka, Y | 1 |
| Boyd, AE; Chen, C; Dillon, JS; Leng, XH; Lu, M; Wheeler, MB | 1 |
| Gespach, CP; Hanson, PJ; McKenna, P; Williams, JM | 1 |
| Brunner, HR; Grouzmann, E; Nicod, P; Thompson, N; Waeber, B; Waeber, G | 1 |
| Eng, J; Fehmann, HC; Göke, B; Göke, R; Krause, M; Linn, T; Schmidt, H | 1 |
| Creutzfeldt, W; Fölsch, UR; Gallwitz, B; Schmidt, WE; Witt, M | 1 |
| Itoh, K; Nakata, M; Yada, T | 1 |
| Creutzfeldt, W; Holst, JJ; Kleine, N; Nauck, MA; Orskov, C; Willms, B | 1 |
| Conlon, JM; Nielsen, PF; Youson, JH | 1 |
| Burrell, MA; Cuttitta, F; Kuijk, M; Martínez, A; Montuenga, LM; Polak, JM; Treston, A | 1 |
| Creutzfeldt, W; Ebert, R; Heimesaat, MM; Holst, JJ; Nauck, MA; Orskov, C | 1 |
| Baxter, LA; Gjinovci, A; Habener, JF; Hendrick, GK; Mojsov, S; Weir, GC; Wollheim, CB | 1 |
| Christiansen, J; Holst, JJ; Mortensen, PE; Myhre, J; Schjoldager, B; Wettergren, A | 1 |
| Holst, JJ; Koch, C; Lanng, S; Nerup, J; Orskov, C; Røder, ME; Thorsteinsson, B | 1 |
| Holst, JJ; Orskov, C; Wettergren, A | 2 |
| Rasmussen, H; Zawalich, KC; Zawalich, WS | 1 |
| Fehmann, HC; Göke, B; Göke, R; Wagner, B | 1 |
| Hayek, A; Otonkoski, T | 1 |
| Arnold, R; Fuder, H; Göke, B; Kleist, P; Littke, T; Lücker, PW; Stridde, E; Theiss, U; Wieckhorst, G | 1 |
| Beak, SA; Bloom, SR; Choi, SJ; Edwards, CM; Ghatei, MA; Gunn, I; Heath, MM; Herbert, J; Lambert, PD; Meeran, K; O'Shea, D; Smith, DM; Taylor, GM; Turton, MD; Wilding, JP | 1 |
| Frölich, M; Gooszen, HG; Guicherit, OR; Lemkes, HH; van der Burg, MP; van Suylichem, PT | 2 |
| Gedulin, BR; Rink, TJ; Young, AA | 1 |
| Flamez, D; Gremlich, S; Heimberg, H; Huypens, P; Ling, Z; Moens, K; Pipeleers, D; Quartier, E; Schuit, F; Thorens, B | 1 |
| Creutzfeldt, W; Holst, JJ; Nauck, MA; Orskov, C; Werner, J; Willms, B | 1 |
| D'Alessio, DA; Eng, J; Ensinck, JW; Koerker, D; Laschansky, E; Prigeon, R; Vogel, R | 1 |
| Chen, C; Hosokawa, H; Hosokawa, YA; Leahy, JL | 1 |
| Arnold, R; Göke, B; Katschinski, M; Schäfer, T; Schirra, J; Wank, U; Weidmann, C | 1 |
| Adelhorst, K; Holst, JJ; Ingwersen, SH; Kirk, O; Larsen, FS; Pridal, L | 1 |
| Göke, R; Larsen, PJ; Mikkelsen, JD; Sheikh, SP | 2 |
| Fletcher, JM; Heath, A; Knapper, JM; Marks, V; Morgan, LM | 1 |
| Kim, Y; Rose, CA | 1 |
| Aponte, GW; Heller, RS | 1 |
| Holst, JJ; Kost, LJ; Phillips, SF; Sarr, MG; Wen, J | 1 |
| Bridenbaugh, R; Göke, B; Göke, R; Hupe-Sodmann, K; McGregor, GP; Thole, H; Voigt, K; Zimmermann, B | 1 |
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| Fehmann, HC; Göke, B; Janssen, M | 1 |
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| Bloom, SR; Fuller, CR; Ghatei, MA; Hoyt, EC; Lund, PK; Ulshen, MH; Winesett, DE | 1 |
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| Holst, JJ; Madsbad, S; Toft-Nielson, M | 1 |
| Holst, JJ; Nauck, MA; Orskov, C; Siemsglüss, J | 1 |
| Blazquez, E; Calvo, JC; Gisolfi, CV; Mora, F | 1 |
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| Bloom, SR; Fuller, CR; Ghatei, MA; Hoyt, EC; Lund, PK; Ulshen, MH | 1 |
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| Fletcher, JM; Knapper, JM; Marks, V; Morgan, LM | 1 |
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| Gama, R; Hampton, S; Marks, V; Morgan, L; Norris, F; Watkins, S; Wright, J | 1 |
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| Fletcher, JM; Knapper, JM; Morgan, LM | 1 |
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| Ahrén, B; Gutniak, MK; Heiber, SJ; Holst, JJ; Juneskans, OT; Larsson, H | 1 |
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| Arnold, R; Eissele, R; Göke, B; Herrmann-Rinke, C | 1 |
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| Alberti, KG; Holst, JJ; Møller, J; Møller, N; Orskov, C; Orskov, L; Schmitz, O | 1 |
| Kawai, K; Nakagawa, Y; Ohashi, S; Suzuki, H; Yamashita, K | 1 |
| Fink-Jensen, A; Göke, R; Jessop, DS; Larsen, PJ; Møller, M; Sheikh, SP; Tang-Christensen, M | 1 |
| Bernstein, IL; Burn, P; Campfield, LA; Donahey, JC; Seeley, RJ; Smith, FJ; Thiele, TE; Van Dijk, G; Woods, SC | 1 |
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| Malaisse, WJ | 1 |
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| Efendic, S; Gutniak, M; Hamsten, A; Juntti-Berggren, L; Karpe, F; Pigon, J; Vignati, L | 1 |
| Byrne, MM; Göke, B | 1 |
| Beck-Nielsen, HB; Holst, JJ; Vaag, AA; Vølund, A | 1 |
| Kieffer, TJ; Kofod, H; Kwong, J; McIntosh, CH; Pauly, R; Pederson, RA | 1 |
| Graal, MB; Wolffenbuttel, BH | 1 |
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| Nakabayashi, H; Nakagawa, A; Niijima, A; Nishizawa, M; Uchida, K | 1 |
| Göke, B; Göke, R; Wilmen, A | 1 |
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| Creutzfeldt, W; Holst, JJ; Nauck, MA; Orskov, C; Werner, J; Willms, B; Wollschläger, D | 1 |
| Beety, JM; Howland, R; Marks, V; Morgan, LM; Ranganath, LR; Wright, JW | 1 |
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| Holst, JJ; Nauck, M; Orskov, C; Toft-Nielsen, MB; Willms, B | 1 |
| Bernstein, IL; Seeley, RJ; Thiele, TE; van Dijk, G; Woods, SC | 1 |
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| Holst, JJ; Keller, U; Shalev, A | 1 |
| Holst, JJ; Larsen, PJ; Orskov, C; Tang-Christensen, M | 1 |
| Gallwitz, B; Schmidt, WE | 2 |
| Barrow, BA; Levy, JC; Rachman, J; Turner, RC | 1 |
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| Furuse, M; Hasegawa, S; Matsumoto, M; Okumura, J; Sugahara, K | 1 |
| Gelling, RW; Gyomorey, S; McIntosh, CH; Nian, C; Pederson, RA; Wheeler, MB; Xue, J | 1 |
| Andreasen, JJ; Holst, JJ; Palnaes Hansen, C | 1 |
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| Ishida, K; Kuwajima, M; Mizuno, A; Murakami, T; Noma, Y; Sato, I; Shima, K; Tateishi, K | 1 |
| Bloom, SR; Edwards, CM; Ghatei, MA; Khan, FA; Todd, JF; Wilding, JP | 1 |
| Barg, S; Ding, WG; Gromada, J; Renström, E; Rorsman, P | 1 |
| Bloom, SR; Edwards, AV; Edwards, CM | 1 |
| Beday, A; Eng, J; Montrose-Rafizadeh, C; Pritchette, LA; Rodgers, BD; Yang, H | 1 |
| Dobashi, Y; Kanno, T; Suga, S; Wakui, M | 1 |
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| Jessop, DS; Larsen, PJ; Tang-Christensen, M | 1 |
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| Crews, EC; Gentry, RM; Rowland, NE | 1 |
| Bloom, SR; Edwards, CM; Ghatei, MA; Goldstone, AP; Gunn, I; Heath, MM; Hoggard, N; Howard, JK; Meeran, K; Mercer, JG; Moar, KM; O'Shea, D; Rasheed, S; Rossi, M; Small, C; Steere, J; Turton, MD | 1 |
| Dobashi, Y; Kanno, T; Nakano, K; Suga, S; Takeo, T; Wakui, M | 1 |
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| Holst, JJ; Nauck, MA; Willms, B | 1 |
| Clemente, F; Perea, A; Valverde, I; Villanueva-Peñacarrillo, ML; Viñambres, C | 1 |
| Ettler, R; Holst, JJ; Nauck, MA; Niedereichholz, U; Orskov, C; Ritzel, R; Schmiegel, WH | 1 |
| Lucius, R; Mentlein, R | 1 |
| Goebell, H; Gröger, G; Holst, JJ; Layer, P; Unger, A | 1 |
| Nishi, S; Taminato, T; Yagi, T | 1 |
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| Gama, R; Hampton, S; Marks, V; Morgan, L; Norris, F; Wright, J | 1 |
| Langeberg, LK; Lester, LB; Scott, JD | 1 |
| Ahrén, B; Gutniak, MK; Holst, JJ; Juneskans, O; Larsson, H; Sanders, SW | 1 |
| Halban, PA; Irminger, JC; Kantengwa, S; Rouillé, Y | 1 |
| D'Alessio, DA; Ensinck, JW; Kahn, SE; Koerker, DJ; Laschansky, EC; Prigeon, RL; Vogel, RE | 1 |
| Bloom, SR; Gunn, I; O'Shea, D | 1 |
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| Butler, PC; Grøfte, B; Holst, JJ; Nyholm, B; Pincus, SM; Pørksen, N; Schmitz, O; Veldhuis, JD | 1 |
| Bokvist, K; Ding, WG; Gromada, J; Holst, JJ; Nielsen, JH; Rorsman, P | 1 |
| Flamez, D; Ling, Z; Moens, K; Pipeleers, D; Schuit, F; Van Schravendijk, C | 1 |
| Chisholm, C; Fung, LC; Greenberg, GR | 1 |
| Blume, N; Holst, JJ; Jensen, HI; Jensen, PB; Larsen, PJ; Madsen, OD; Mikkelsen, JD | 1 |
| Adner, N; Gutniak, M; Holst, JJ; Svartberg, J | 1 |
| Ahrén, B; Gutniak, M | 1 |
| Astrup, A; Flint, A; Holst, JJ; Raben, A | 1 |
| Bernier, M; Egan, JM; Kole, HK; Montrose-Rafizadeh, C; Perfetti, R; Wang, Y | 1 |
| Bode, HP; Göke, B; Göke, R; Hareter, A; Hoffmann, E | 1 |
| Furuse, M; Hasegawa, S; Matsumoto, M; Saito, N; Sugahara, K | 1 |
| Donahey, JC; Seeley, RJ; van Dijk, G; Woods, SC | 1 |
| Gromada, J; Holst, JJ; Rorsman, P | 1 |
| Bode, HP; Ebert, T; Fehmann, HC; Göke, B; Karl, A | 1 |
| Yada, T; Yaekura, K | 1 |
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| Arnold, R; Beglinger, C; Göke, B; Hildebrand, P; Katschinski, M; Leicht, P; Schirra, J | 1 |
| Arnold, R; Byrne, MM; Göke, B; Katschinski, M; Pluntke, K; Schirra, J; Wank, U | 1 |
| Beak, SA; Bloom, SR; Buckingham, JC; Ghatei, MA; Heath, MM; Morgan, DG; Small, CJ; Smith, DM; Taylor, AD | 1 |
| Marks, V; Morgan, L; Norris, F; Ranganath, L; Wright, J | 3 |
| Chang, JJ; Heffernan, JK; Kontor, KM; Krakover, J; Kreilgaard, L; Patel, S; Rosenberg, GB; Senderoff, RI; Snell, LB | 1 |
| Drucker, DJ | 8 |
| Brader, ML; Clodfelter, DK; Destrampe, KA; Havel, HA; Myers, SR; Pekar, AH; Rebhun, DM | 1 |
| Arnold, R; Göke, B; Katschinski, M; Leicht, P; Schirra, J; Sturm, K | 1 |
| Brubaker, PL; Dhanvantari, S | 1 |
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| Boyd, AE; Dillon, JS; Leng, XH; Ligon, BB; Wheeler, MB | 1 |
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| Compton, DS; Davis, HR; France, CF; Graziano, MP; Hoos, LM; Mullins, DE; Pines, JM; Strader, CD; Sybertz, EJ; Van Heek, M | 1 |
| Dean, RA; Fraser, ID; Langeberg, LK; Lester, LB; Marrion, NV; Scott, JD; Tavalin, SJ; Westphal, AM | 1 |
| Pohl, M; Wank, SA | 1 |
| Matsuno, S; Naito, H; Sasaki, I | 1 |
| Holst, JJ; Larsen, S; Olsen, O; Rehfeld, JF; Sternby, B; Wettergren, A; Wøjdemann, M | 1 |
| Armstrong, E; Blackshaw, PE; Buchanan, KD; King, P; Kong, MF; Macdonald, IA; Perkins, AC; Tattersall, RB | 1 |
| Benito, E; Blazquez, E; Bosch, MA | 1 |
| Larsen, PJ; Tang-Christensen, M; Vrang, N | 3 |
| Brubaker, PL; Cook, SM; Drucker, DJ; Marshall, BA; Scrocchi, LA | 1 |
| Drucker, DJ; Flamez, D; Pipeleers, D; Quartier, E; Schuit, F; Scrocchi, LA; Van Breusegem, A | 1 |
| Keller, U; Ninnis, R; Shalev, A | 1 |
| Luque, MA; Márquez, L; Trapote, MA; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Deacon, CF; Holst, JJ; Hughes, TE | 1 |
| López-Delgado, MI; Malaisse, WJ; Morales, M; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Bloom, SR; Brynes, AE; Edwards, CM; Frost, GS; Ghatei, MA | 2 |
| Abello, J; Bosshard, A; Chayvialle, JA; Chevrier, AM; Cuber, JC; Saïfia, S | 1 |
| Creutzfeldt, W; Holst, JJ; Idowu, K; Nauck, MA; Willms, B | 1 |
| Bergmann, J; Holst, JJ; Nauck, MA; Ritzel, R; Schmiegel, W; Seifarth, C | 1 |
| Anvari, M; Daniel, EE; McDonald, TJ; Paterson, CA | 1 |
| Seeley, RJ; Woods, SC | 1 |
| Bernard, C; Chayvialle, JA; Cordier-Bussat, M; Cuber, JC; Klages, N; Laser-Ritz, B; Levenez, F; Philippe, J | 1 |
| Habener, JF; Leech, CA | 2 |
| Delzenne, NM; Kok, NN; Morgan, LM; Roberfroid, MB; Thissen, JP; Williams, CM | 1 |
| Giralt, M; Vergara, P | 2 |
| Egan, JM; Elahi, D; Habener, JF; Ryan, AS | 1 |
| Ghibaudi, L; Hwa, JJ; Strader, CD; Tedesco, R; Williams, P; Witten, MB | 1 |
| Holst, JJ; Wettergren, A; Wøjdemann, M | 2 |
| Backman, L; Hellström, PM; Holst, JJ; Näslund, E; Theodorsson, E | 1 |
| Abdel-Wahab, YH; Conlon, JM; Nielsen, PF; O'Harte, FP; Whittaker, J | 1 |
| Ahrén, B; Simonsson, E | 1 |
| Horowitz, M; Jones, KL; Morris, HA; Nauck, MA; Wishart, JM | 1 |
| Arnold, R; Byrne, MM; Gliem, K; Göke, B; Katschinski, M; Polonsky, KS; Wank, U | 1 |
| Efendic, S; Gutniak, M; Hellström, PM; Holst, JJ; Tolessa, T | 2 |
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| Beavo, JA; Bornfeldt, KE; Zhao, AZ | 1 |
| Bernstein, IL; D'Alessio, D; Eng, J; Seeley, RJ; Thiele, TE; van Dijk, G; Woods, SC | 1 |
| Bloom, SR; Edwards, CM; Ghatei, MA; Mather, HM; Todd, JF | 1 |
| Egan, JM; Montrose, MH; Montrose-Rafizadeh, C; Moyes, CD; Roth, J; Wang, Y; Yang, H | 1 |
| Gutniak, M; Hellström, PM; Näslund, E; Rössner, S; Skogar, S | 1 |
| Andrews, J; Horowitz, M; Lavin, JH; Morley, JE; Morris, HA; Read, NW; Wishart, JM; Wittert, GA; Yeap, B | 1 |
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| Boissart, C; Leclercq-Meyer, V; Malaisse, WJ; Pessah, M; Rosselin, G | 1 |
| Bachelot, I; Bottari, SP; Chabre, O; Chaffanjon, P; Chambaz, EM; Defaye, G; Feige, JJ; Labat-Moleur, F; Liakos, P; Martinie, M; Vivier, J | 1 |
| Hansen, BF; Jensen, P; Nepper-Christensen, E; Skjølstrup, B | 1 |
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| Peterson, RG; Roth, MD; Shen, HQ | 1 |
| Brubaker, PL; Drucker, DJ; Schloos, J | 1 |
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| Field, CJ; Hayek, MG; Keelan, M; Massimino, SP; McBurney, MI; Sunvold, GD; Thomson, AB | 1 |
| Gutniak, M | 1 |
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| Fehmann, HC; Göke, B; Pracht, A | 1 |
| Deacon, CF; Holst, JJ | 4 |
| Flier, ES; Gillette, J; Ludwig, DS; Maratos-Flier, E; Tritos, NA; Vicent, D | 1 |
| Holst, JJ; Madsbad, S; Toft-Nielsen, M | 1 |
| Abdel-Wahab, YH; Conlon, JM; Flatt, PR; O'Harte, FP | 1 |
| Dolci, W; Drucker, D; Efrat, S; Schaerer, E; Scrocchi, L; Serre, V; Thorens, B | 1 |
| Eckart, K; Leonhardt, U; Ottleben, M; Ramadori, G; Ritzel, U; Rühmann, A; Spiess, J | 1 |
| Adam, CL; Findlay, PA; Hoggard, N; Mercer, JG; Moar, KM | 1 |
| Holst, JJ; Nauck, MA; Ritzel, R; Sauerwald, A; Schmiegel, W | 1 |
| Holst, JJ; Pridal, L; Wettergren, A; Wøjdemann, M | 1 |
| Barcelo, A; Chayvialle, JA; Claustre, J; Cuber, JC; Moro, F; Plaisancié, P | 1 |
| Bach, I; Holst, JJ; Nauck, MA; Orskov, C; Richter, S; Schmiegel, W; Weber, I | 1 |
| Bloom, SR; Edwards, CM; Ghatei, MA; Todd, JF | 1 |
| Marks, V; Morgan, L; Ranganath, L; Sedgwick, I; Wright, J | 1 |
| Nauck, MA | 2 |
| Cheng, BL; Coy, DH; Jiang, NY; Rossowski, WJ | 1 |
| Beglinger, C; Conen, D; Drewe, J; Göke, B; Gutzwiller, JP; Handschin, D; Hildebrand, P; Ketterer, S; Winterhalder, R | 1 |
| Bloom, SR; Ghatei, MA; Hurley, JD; Karlsen, AE; Kulkarni, RN; Morgan, DG; Smith, DM; Wang, RM; Wang, ZL | 1 |
| Mamujee, SN; Sun, AM; Vacek, I; Wheeler, MB; Zhou, D | 1 |
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| Bloom, SR; Brynes, AE; Edwards, CM; Frost, GS; Ghatei, MA; Jadhav, A | 1 |
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| Asmar, M; Deacon, CF; Hare, KJ; Holst, JJ; Knop, FK; Vilsbøll, T | 1 |
| Cobelli, C; Dalla Man, C; Micheletto, F; Rizza, RA; Sathananthan, A; Vella, A | 1 |
| Asmar, M; Bache, M; Holst, JJ; Knop, FK; Madsbad, S | 1 |
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| Chapman, MJ; Deane, AM; Fraser, RJ; Horowitz, M; Jones, KL; Rayner, CK; Storey, JP; Summers, MJ; Zaknic, AV | 1 |
| Han, LP; Sha, WW; Wang, JC; Wang, SX; Wang, WL; Xie, Y; Yu, DM; Zhou, X | 1 |
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| Bellon, M; Fraser, RJ; Holloway, RH; Horowitz, M; Jones, KL; Kuo, P; Rayner, CK; Smout, AJ; Wishart, JM | 1 |
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| Barton, RW; Brzezinski, M; Fuller, JM; Kernan, K; Lernmark, A; Moralejo, D; Osborne, WR; Yanay, O | 1 |
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| Accili, D; Ahrén, B; Boitard, C; Cerasi, E; Henquin, JC; Seino, S | 1 |
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| Ahmad, Z; Allaudin, ZN; Omar, AR; Rasouli, M | 1 |
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| Hazama, M; Johnson, PR; Rorsman, P; Takeuchi, K; Tsujihata, Y; Yashiro, H | 1 |
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| Kuwayama, H; Nakashima, K; Saito, T; ThanThan, S; Yannaing, S; Zhao, H | 1 |
| Aaboe, K; Holst, JJ; Knop, FK; Krarup, T; Madsbad, S; Vilsbøll, T; Vølund, A | 1 |
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| Almdal, T; Bojsen-Møller, KN; Clausen, TR; Dirksen, C; Hansen, DL; Holst, JJ; Hvolris, LE; Jacobsen, SH; Jørgensen, NB; Kielgast, U; Madsbad, S; Naver, LS; Olesen, SC; Rehfeld, JF; Worm, D; Wulff, BS | 1 |
| Bøtker, H; Frandsen, E; Halbirk, M; Holst, JJ; Møller, N; Nielsen, R; Nielsen, S; Nørrelund, H; Schmitz, O; Wiggers, H | 1 |
| Harikumar, KG; Ke, J; Miller, LJ; Mowry, LE; Wang, L; Williams, BO; Xu, HE; Zhang, C; Zylstra-Diegel, CR | 1 |
| Cobelli, C; Dalla Man, C; Micheletto, F; Sathananthan, A; Sathananthan, M; Smushkin, G; Vella, A; Zinsmeister, AR | 1 |
| Bojsen-Møller, KN; Clausen, TR; Dirksen, C; Holst, JJ; Hvolris, L; Jacobsen, SH; Jørgensen, NB; Lindqvist Hansen, D; Madsbad, S; Naver, L; Worm, D; Wulff, BS | 1 |
| Adriaenssens, A; Gribble, FM; Koepsell, H; Parker, HE; Reimann, F; Richards, P; Rogers, G | 1 |
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| Chen, L; da Silva Xavier, G; French, PM; McGinty, JA; Mondragon, A; Rutter, GA; Sun, G | 1 |
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| Calabria, AC; De León, DD; Gallagher, PR; Li, C; Stanley, CA | 1 |
| Færch, K; Hansen, T; Holst, JJ; Jørgensen, T; Knop, FK; Pedersen, O; Pilgaard, K | 1 |
| Cao, X; Drucker, DJ; Flock, GB; Maziarz, M | 1 |
| Ananthakrishnan, G; Chabenne, JR; Chaudhary, N; DiMarchi, R; Drucker, DJ; Heppner, KM; Lockie, SH; Morgan, DA; Oldfield, BJ; Perez-Tilve, D; Rahmouni, K; Rohner-Jeanrenaud, F; Tschöp, MH; Veyrat-Durebex, C | 1 |
| Boggi, U; Bugliani, M; D'Aleo, V; Del Guerra, S; Dotta, F; Filipponi, F; Grieco, FA; Kirkpatrick, CL; Lupi, R; Marchetti, P; Marselli, L; Piro, S; Purrello, F; Salvini, L; Sebastiani, G; Tinti, L; Wollheim, CB | 1 |
| Hashimoto, N; Hirota, Y; Matsuda, T; Nakamura, T; Ogawa, W; Sakaguchi, K; Seino, S; Takabe, M | 1 |
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| van der Klauw, MM; Wolffenbuttel, BH | 1 |
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| Cobelli, C; Dalla Man, C; Law, JH; Piccinini, F; Rizza, RA; Sathananthan, M; Smushkin, G; Vella, A; Zinsmeister, AR | 1 |
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| Chen, C; Chen, Z; Han, Y; Shen, J; Zhu, X | 1 |
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| Bagger, JI; Bonde, L; Holst, JJ; Knop, FK; Larsen, S; Nielsen, T; Svare, JA; Vilsbøll, T | 1 |
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| Holst, JJ; Lehrskov-Schmidt, L; Møller, K; Nielsen, ST; Solomon, TP | 1 |
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| Afman, L; Amer, B; Bjørnshave, A; Bohl, M; Christensen, MM; Dalsgaard, TK; Gregersen, S; Hermansen, K; Herrmann, A; Holst, JJ; Jensen, E; Larsen, MK; O'Driscoll, L; O'Neill, S; Rasmussen, KV; Schioldan, AG | 1 |
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| Bagger, JI; Hansen, T; Hartmann, B; Holst, JJ; Knop, FK; Pedersen, O; Vilsbøll, T; Østoft, SH | 1 |
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| Bocchio-Chiavetto, L; Cattaneo, A; Gennarelli, M; Maina, G; Rosso, G; Zanardini, R | 1 |
| Deacon, CF; Hartmann, B; Holst, JJ; Knop, FK; Plamboeck, A; Veedfald, S; Vilsbøll, T | 2 |
| Hansen, HS; Hansen, KB; Hartmann, B; Holst, JJ; Mandøe, MJ; Rehfeld, JF | 1 |
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| Cho, YM; Lee, HJ; Oh, TJ | 1 |
| Ahrén, B; Alsalim, W; Bizzotto, R; Mari, A; Omar, B; Pacini, G; Tura, A | 1 |
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| Ayanoglu, G; Bak, MJ; Castro-Perez, J; Chappell, DL; Churakova, T; Judo, M; Lassman, ME; Laterza, OF; Lee, AY; Liang, L; Previs, S; Souza, SC; Zhou, H | 1 |
| Bailey, SR; Bamford, NJ; Baskerville, CL; Harris, PA | 1 |
| Andersen, B; Bagger, JI; Hartmann, B; Holst, JJ; Knop, FK; Vilsbøll, T | 1 |
| Cahen, DL; Kramer, MH; Muskiet, MH; Smits, MM; Tonneijck, L; van Raalte, DH | 1 |
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| Augstein, P; Bandala-Sanchez, E; Campbell, P; Harrison, LC; Hawthorne, WJ; Heinke, P; Kay, TW; Loudovaris, T; Naselli, G; Rogers, K; Thomas, HE | 1 |
| Holst, B; Holst, JJ; Jensen, SM; Madsen, AN; Pedersen, J; Poulsen, SS; Quistorff, B; Steenberg, VR; Windeløv, JA | 1 |
| Ahrén, B; Farngren, J; Persson, M | 1 |
| Clifton, PM; Feinle-Bisset, C; Hausken, T; Horowitz, M; Hutchison, AT; Jones, KL; Luscombe-Marsh, ND; Piscitelli, D; Standfield, S | 1 |
| Chen, H; Luo, N; Wang, Y; Zhang, Z; Zhu, Y | 1 |
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| Gluud, LL; Holst, JJ; Junker, AE; Knop, FK; van Hall, G; Vilsbøll, T | 1 |
| Bagger, JI; Christensen, M; Grøndahl, M; Hansen, CP; Hartmann, B; Holst, JJ; Hornburg, D; Knop, FK; Larsen, S; Lund, A; Mann, M; Mathiesen, ER; Meissner, F; Rehfeld, JF; Storkholm, JH; van Hall, G; Vilsbøll, T; Wewer Albrechtsen, NJ | 1 |
| Ahlkvist, L; Ahrén, B; Fosgerau, K; Omar, B; Valeur, A | 1 |
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| Gluud, L; Holst, JJ; Junker, AE; Knop, FK; Vilsbøll, T | 1 |
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| Borg, M; Bound, MJ; Deacon, CF; Horowitz, M; Jones, KL; Little, TJ; Rayner, CK; Wu, T; Zhang, X | 1 |
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| Cho, YM; Kim, EK; Kim, LK; Oh, TJ | 1 |
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| Hedenqvist, P; Jensen-Waern, M; Manell, E; Svensson, A | 1 |
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| Beglinger, C; Cajacob, L; Drewe, J; Herzog, R; Meyer-Gerspach, AC; Riva, D; Wölnerhanssen, BK | 1 |
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| Bjornvad, CR; Cronin, AM; Hoelmkjaer, KM; Holst, JJ; Mandrup-Poulsen, T; Nielsen, DH; Wewer Albrechtsen, NJ | 1 |
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| Allsop, S; Green, BP; Rumbold, PL | 1 |
| Oestricker, L; Patterson, BW; Reeds, DN; Sterl, K; Wallendorf, MJ; Wang, S; Wice, BM | 1 |
| Arslanian, S; Bacha, F; Hannon, T; Hughan, KS; Kim, JY; Lee, S; Michaliszyn, SF; Nasr, A; Tfayli, H | 1 |
| Chowdhury, S; Dunai, J; Kilpatrick, R; Oestricker, LZ; Patterson, BW; Reeds, DN; Wallendorf, MJ; Wang, S; Wice, BM | 1 |
| Abrahamsson, N; Börjesson, JL; Eriksson, JW; Karlsson, FA; Sundbom, M; Wiklund, U | 1 |
| Casajoana, A; de Gordejuela, AG; Duran, X; Espinet, E; Galvao, M; López-Urdiales, R; Pérez, M; Pujol, J; Toro, S; Vendrell, J; Vilarrasa, N | 1 |
| Cuchel, M; De Leon, DD; Gudipaty, L; Hadjiliadis, D; Kelly, A; Kubrak, C; Malik, S; Nyirjesy, SC; Peleckis, AJ; Rickels, MR; Rosenfeld, NK; Rubenstein, RC; Sheikh, S; Stefanovski, D | 1 |
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| Chamarthi, B; Chen, L; Florez, JC; Goldfine, A; Hudson, M; Kaur, V; Littleton, KR; Manning, AK; Merino, J; Srinivasan, S; Thomas, MK | 1 |
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| Adams-Huet, B; Burgess, S; Li, X; Lingvay, I; Mari, A; Mitchell, L; Pop, LM; Zhao, TJ | 1 |
| Engelbrechtsen, L; Færch, K; Gjesing, AP; Grarup, N; Hansen, T; Holst, JJ; Jonsson, A; Jørgensen, ME; Jørgensen, T; Kanters, JK; Mahendran, Y; Pedersen, O; Torekov, S; Vestergaard, H; Weeke, PE; Witte, DR | 1 |
| Gribble, FM; Hardwick, RH; Howard, J; Kay, RG; Reimann, F; Roberts, GP | 1 |
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| Avogaro, A; Fadini, GP | 1 |
| Berger, C; Friedrich, A; Koepsell, H; Metzger, M; Mühlemann, M; Otto, C; Walles, H; Zdzieblo, D | 1 |
| Charron, MJ; Drucker, DJ; Matthews, D; Patel, A; Seeley, RJ; Yusta, B | 1 |
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| Clarke, SD; Feinle-Bisset, C; Heruc, GA; Horowitz, M; Kohn, MR; Little, TJ; Madden, S | 1 |
| Balk-Møller, E; Christiansen, CB; Dahlby, T; Deacon, CF; Hartmann, B; Holst, JJ; Kuhre, RE; Lind, SJ; Mandrup-Poulsen, T; Svendsen, B; Wewer Albrechtsen, NJ | 1 |
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| Egerod, KL; Ekberg, JP; Engelstoft, MS; Feng, Y; Gribble, F; Hjorth, SA; Holst, JJ; Howard, AD; Mokrosinski, J; Munk, A; Petersen, N; Rehfeld, JF; Reimann, F; Rudenko, O; Schwartz, TW; Shang, J; Thams, P; Treebak, JT; Wu, M; Zhou, YP | 1 |
| Di Mauro, S; Di Pino, A; Filippello, A; Piro, S; Purrello, F; Rabuazzo, AM; Scamporrino, A; Scicali, R; Urbano, F | 1 |
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| Broberg, B; Christensen, KB; Feldt-Rasmussen, B; Fuglsang, S; Holst, JJ; Hornum, M; Idorn, T; Madsen, JL; Rydahl, C | 1 |
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| Bojsen-Møller, KN; Dirksen, C; Hartmann, B; Holst, JJ; Kristiansen, VB; Madsbad, S; Martinussen, C; Svane, MS | 1 |
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| Andersson, T; Chorell, E; Holst, JJ; Larsson, C; Lindahl, B; Mellberg, C; Olsson, T; Otten, J; Ryberg, M | 1 |
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| Clemmensen, C; Frølund, B; Petersen, J; Strømgaard, K | 1 |
| Andries, A; Christensen, MM; Falkenhahn, M; Forman, JL; Friis, S; Holst, JJ; Jelsing, J; Jorsal, T; Juhl, CB; Knop, FK; Langholz, E; Larsen, PJ; Mortensen, B; Musholt, PB; Støving, RK; Sørensen, F; Theis, S; Vilsbøll, T; Vrang, N; Wandall, E; Wewer Albrechtsen, NJ; Worm, D; Ørskov, C | 1 |
| Contreras, C; Diéguez, C; González-García, I; López, M; Milbank, E | 1 |
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| Bagger, JI; Bergmann, NC; Christensen, MB; Knop, FK; Lund, A; Mathiesen, DS; Vilsbøll, T | 1 |
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| Brandi, L; Bressendorff, I; Feldt-Rasmussen, B; Hansen, HP; Hartmann, B; Holst, JJ; Hornum, M; Idorn, T; Jørgensen, MB; Knop, FK; Rydahl, C; van Hall, G; Wewer Albrechtsen, NJ | 1 |
| Cardone, RL; Cravatt, BF; Gillum, MP; Grevengoed, TJ; Kibbey, RG; Knop, FK; McKinney, MK; Nexøe-Larsen, CC; Ogasawara, D; Petersen, N; Schwartz, TW; Svenningsen, JS; Trammell, SAJ | 1 |
| Albinsson-Stenholm, E; Bergsén, J; Guldbrand, H; Ingves, S; Nystrom, FH; Vilhelmsson, N | 1 |
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| Aihara, E; Inaba, A; Iwatsuki, K; Matsumoto, M; Ninomiya, Y; Ohki, J; Oishi, Y; Sakashita, A; Uchiyama, H; Yamane, T | 1 |
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| Bojsen-Møller, KN; Dirksen, C; Fenger, M; Holst, JJ; Kristiansen, VB; Madsbad, S; Martinussen, C; Svane, MS; van Hall, G; Veedfald, S; Wewer Albrechtsen, NJ | 1 |
| Fukui, M; Hashimoto, Y; Imai, S; Kajiyama, S; Matsumoto, S; Miyawaki, T; Nitta, A; Ozasa, N; Saito, Y | 1 |
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| Abdel-Wahab, YH; Conlon, JM; Flatt, PR; Graham, GV | 1 |
| Fujita, Y; Haneda, M; Honjo, J; Takeda, Y; Yanagimachi, T; Yokoyama, H | 1 |
| Barr, A; Campbell, SA; Golec, DP; Hubert, M; Johnson, J; Light, PE; MacDonald, PE; Philippaert, K; Salamon, N | 1 |
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| Chen, L; Guo, X; Hou, X; Li, D; Li, X; Song, J; Wang, L; Wang, M; Yang, Q; Yang, Y | 1 |
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| Feinle-Bisset, C; Fitzgerald, PCE; Herbillon, B; Horowitz, M; Manoliu, B; Steinert, RE | 1 |
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| Bao, S; Chen, D; Hu, L; Jiang, H; Li, J; Liu, J; Liu, W; Sun, S; Wang, X; Xie, Z; Zhang, X; Zhang, Y; Zhou, C | 1 |
| Armaghanian, N; Brand-Miller, J; Chua, EL; Hetherington, J; Markovic, TP; Parameswaran, V; Steinbeck, K | 1 |
| Arciszewski, MB; Krzysiak, M; Mozel, S; Puzio, I; Szymańczyk, S; Zacharko-Siembida, A | 1 |
| Bouskela, E; Braga, TG; Dellatorre-Teixeira, L; Graças Coelho de Souza, MD; Kraemer-Aguiar, LG; le Roux, CW; Menezes, M; Nogueira Neto, JF | 1 |
| Argueta, DA; Basappa, KR; Bishay, AE; Carrillo, V; Chinthirla, BD; Currás-Collazo, MC; DiPatrizio, NV; González, GM; Kozlova, EV; Krum, JM; Pérez, PA; Phillips, AL; Stapleton, HM | 1 |
| Burling, K; Gribble, F; Lewis, HB; Meek, CL; Reimann, F | 1 |
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| Barker, G; Bernal-Mizrachi, E; Blandino-Rosano, M; Bozadjieva Kramer, N; Caicedo, A; Gittes, GK; Lubaczeuski, C | 1 |
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| Beglinger, C; Dellatorre-Teixeira, L; Drewe, J; Hartmann, B; Holst, JJ; Meyer-Gerspach, AC; Peterli, R; Rehfeld, JF; Roux, CWL; Tack, J; Verbeure, W; Wölnerhanssen, BK | 1 |
| Gu, X; Huang, F; Huang, M; Huang, P; Ma, R; Meng, L; Tan, J; Wang, J | 1 |
| Chataway, T; Colella, AD; de Fontgalland, D; Hollington, P; Keating, DJ; Martin, AM; Rabbitt, P; Spencer, NJ; Sposato, L; Sun, EW; Wattchow, DA; Wewer Albrechtsen, NJ; Young, RL | 1 |
| Alarcon Ramos, GC; Bharmal, SH; Cameron-Smith, D; Cho, J; Ko, J; Petrov, MS | 1 |
| Babu, SN; Govindarajan, S; Noor, A; Vijayalakshmi, MA | 1 |
| Almorza-Gomar, D; Bancalero-delosReyes, J; Camacho-Ramírez, A; Carrasco-Molinillo, C; Fernández-Vivero, J; Macías-Rodríguez, M; Mayo-Ossorio, MÁ; Perez-Arana, GM; Prada-Oliveira, JA; Ribelles-García, A | 1 |
| Bagger, JI; Grøndahl, MFG; Holst, JJ; Knop, FK; Lund, A; Vilsbøll, T | 1 |
| Campbell, SA; Johnson, J; Light, PE | 1 |
| Lewis, GF; Nahmias, A; Stahel, P; Tian, L; Xiao, C | 1 |
| Ardévol, A; Beltrán-Debón, R; Blay, M; Ginés, I; Grau-Bové, C; Pinent, M; Terra, X | 1 |
| Dos Santos, T; MacDonald, PE | 1 |
| Beaumont, M; Grathwohl, D; Macé, K; Monnard, C; Sauser, J; Shahkhalili, Y; Zufferey, CA | 1 |
| Engelhardt, JF; Gibson-Corley, KN; He, N; Liang, B; Norris, AW; Sun, X; Uc, A; Yi, Y | 1 |
| Bojsen-Møller, KN; Clausen, TR; Holst, JJ; Jonsson, I; Kristiansen, VB; Kuhre, RE; Madsbad, S; Rehfeld, JF; Svane, MS; Veedfald, S; Wewer Albrechtsen, NJ | 1 |
| Flatt, PR; Gault, VA; Irwin, N; Lafferty, RA; O'Harte, FPM | 1 |
| Ahrén, B; Seino, Y; Yamada, Y | 1 |
| Allerton, DM; Bowden Davies, KA; Brunsgaard, LH; Smith, K; Stevenson, EJ; Taylor, GS; West, DJ | 1 |
| Bräuner-Osborne, H; Hauser, AS; Lindquist, P; Madsen, JS; Rosenkilde, MM | 1 |
| Buteau, J; Chan, CB; Field, CJ; Fouhse, JM; Ju, T; Mills, E; Qiu, H; Sosa Alvarado, C; Willing, BP; Yang, K | 1 |
| Foreman, RE; George, AL; Gribble, FM; Kay, RG; Reimann, F | 1 |
| Kieffer, TJ; Ramzy, A | 1 |
| Broughton, KS; LeMieux, MJ; Rao, M; Zumbro, EL | 1 |
| Cao, XY; Li, DL; Lu, JW; Wang, XY; Zeng, ZY | 1 |
| Bethea, M; Bozadjieva-Kramer, N; Sandoval, DA | 1 |
| Hoshino, R; Kamiyama, T; Kondo, S; Kosakamoto, H; Matsuoka, R; Nakamura, A; Niwa, R; Obata, F; Tanimoto, H; Yoshinari, Y | 1 |
| Binkowski, S; Davis, EA; Harray, AJ; Horowitz, M; Jones, T; Keating, BL; King, BR; Paramalingam, N; Smart, CEM; Smith, G; Standfield, S | 1 |
| Bouvard, B; Legrand, E; Mabilleau, G; Mieczkowska, A | 1 |
| Biggs, E; Foreman, R; Galvin, SG; Gribble, FM; Jermutus, L; Kay, RG; Larraufie, P; Meek, CL; Ravn, P; Reimann, F | 1 |
| Borg, MJ; Horowitz, M; Jones, KL; Rayner, CK; Wu, T; Xie, C | 1 |
| Holst, JJ; Rehfeld, JF; Svendsen, LB; van Hall, G; Veedfald, S | 1 |
| Kim, DH; Kim, GM; Kim, JI; Kim, S; Kim, YJ; Lee, HJ; Lee, J; Park, BG; Park, ZY; Ryu, JH; Seong, JY | 1 |
| Angarita, L; Bermúdez, V; Cabrera de Bravo, M; Cano, C; Chacín, M; D'Marco, L; Guerrero-Wyss, M; Manzano, A; Martínez, MS; Nava, M; Olivar, LC; Ortiz, R; Salazar, J | 1 |
| Neill, U | 1 |
| Chen, L; Han, C; Liu, Y; Mehta, S; Peng, X; Yang, G; Zhang, J; Zhang, Y; Zhu, W | 1 |
| Cho, HS; Choi, SH; Hwang, H; Hwang, SH; Kim, HC; Lee, R; Nah, SY; Rhim, H | 1 |
| Andersen, DB; Holst, JJ | 1 |
| Choi, YK; Jeon, JH; Kwon, OK; Park, JY; Park, KB | 1 |
| Ai, M; Aviello, G; Boudjadja, MB; Coskun, T; Costa, A; Culotta, I; D'Agostino, G; Emmerson, PJ; Hodson, DJ; Hunter, J; Luckman, SM; Nunn, N; Snider, BM; Valencia-Torres, L | 1 |
| Mandarim-de-Lacerda, CA; Spezani, R | 1 |
| Forman, JL; Gasbjerg, LS; Holst, JJ; Hædersdal, S; Knop, FK; Lund, A; Maagensen, H; Nielsen-Hannerup, E; Rosenkilde, MM; van Hall, G; Vilsbøll, T | 1 |
| Arends, R; Bosch, R; Hoefman, S; Petrone, M; Sijbrands, EJG; Snelder, N; Vicini, P | 1 |
| Cabrera, O; Chepurny, OG; Echeverri, F; Ficorilli, J; Holz, GG; Leech, CA; Schwede, F; Shaw, J | 1 |
| Bao, J; Li, L; Liu, D; Lv, Y; Ni, M; Qi, L; Sj, P; Su, J; Wang, L; Wang, Q; Wei, Q; Xia, H | 1 |
| Douros, JD; Finan, B | 1 |
| Gormsen, LC; Jessen, N; Johannsen, M; Møller, N; Nielsen, CB; Pedersen, MGB; Rittig, N; Søndergaard, E | 1 |
| Feinle-Bisset, C; Hajishafiee, M; Horowitz, M; Lange, K; McVeay, C; Rehfeld, JF | 1 |
| Bando, S; Fujimoto, K; Ichikawa, R; Miyatsuka, T; Motomiya, T; Shichiri, M; Taguchi, M; Taguchi, T; Takano, K | 1 |
| Angelidi, AM; Gavrieli, A; Kalra, B; Kumar, A; Mantzoros, CS; Perakakis, N; Yannakoulia, M | 1 |
| Anno, M; Fujioka, Y; Imamura, T; Ito, Y; Izawa, S; Kato, M; Kitao, S; Matsumoto, K; Matsuzawa, K; Nakamura, R; Okura, H; Okura, T; Shoji, K; Taniguchi, SI; Ueta, E; Yamamoto, K | 1 |
| Dzyuba, B; Hay, WW; Lu, C; Qiao, L; Saget, S; Shao, J; Zang, T | 1 |
| Bao, J; Cheng, H; Li, L; Liu, D; Lv, Y; Qi, L; Qiu, Y; Su, J; Su, X; Sun, J; Wei, Q; Ye, Z; Yu, X; Zhang, Y | 1 |
| Chang, R; Chen, LN; Chen, Y; Cong, Z; Dai, A; Feng, W; Hang, K; Liang, A; Ming, Q; Wang, M; Wang, MW; Wu, B; Xia, T; Xu, HE; Xu, P; Yang, D; Zhang, C; Zhang, Y; Zhao, F; Zhao, L; Zhou, Q; Zou, X | 1 |
| Dornonville de la Cour, C; Guo, T; Jeppesen, JF; Kruse, T; Lau, J; McGuire, J; Niss, K; Raun, K; Sauerberg, P; Simonsen, L | 1 |
| Eliasson, L; Wendt, A | 1 |
| Fujisawa, H; Hayashi, Y; Hidaka, S; Himeno, T; Hori, M; Kamiya, H; Kuwata, H; Maekawa, R; Masuda, A; Nakamura, J; Seino, Y; Shibata, M; Sugimura, Y; Suzuki, A; Takano, Y; Takayanagi, T; Tsunekawa, S; Ueno, S; Yabe, D; Yamamoto, M; Yokota, K | 1 |
| Chepurny, OG; Collier, JJ; Cooney, RN; Holz, GG; Leech, CA; Meng, Q; Molnar, ME; Pruekprasert, N | 1 |
| Bitarafan, V; Feinle-Bisset, C; Horowitz, M; Lange, K; Rehfeld, JF; Rezaie, P; Rose, BD | 1 |
| Cheng, Z; Dong, S; Hu, S; Rayner, C; Wang, K; Wu, T; Zhang, G; Zhang, X; Zhong, M | 1 |
| Flatt, PR; Franklin, ZJ; Irwin, N; Lafferty, RA; McShane, LM; O'Harte, FPM | 1 |
| Feigh, M; Harris, MS; Nestor, JJ; Parkes, D; Suschak, JJ | 1 |
| Kaku, K; Kimura, T | 1 |
| Barbot, M; Basso, D; Ceccato, F; Giordano, C; Guarnotta, V; Mondin, A; Regazzo, D; Scaroni, C | 1 |
| Bukrinski, JT; Frimann, TM; Harris, P; Ko, SK; Peters, GHJ | 1 |
| Chanon, S; Chavanelle, V; Le Joubioux, F; Loizon, E; Maugard, T; Morio, B; Otero, YF; Peltier, SL; Pinteur, C; Sirvent, P; Vial, G | 1 |
| Holst, JJ; Laferrère, B; Mark, V; Prasad, M; Shah, A | 1 |
| Castro, RA; Gilor, C; Hill, RC; O'Kell, AL; Pascutti, KM; Salute, ME | 1 |
| Deng, H; Feng, L; Han-Zhang, H; Jiang, H; Li, L; Liu, M; Ma, Q; Pang, S; Qian, L; Song, B; Yang, W; Yu, T; Zhang, Y | 1 |
| D'Alessio, DA; De Leon, DD; Doliba, A; Eiel, JN; Flatt, AJ; Gallagher, K; Gallop, R; Hadjiliadis, D; Kelly, A; Nyirjesy, SC; Peleckis, AJ; Rickels, MR; Rubenstein, RC; Sheikh, S; Stefanovski, D; Tami, A | 1 |
| DiMarchi, RD; Douros, JD; Finan, B; He, Y; Hjøllund, KR; Knerr, PJ; Kruse Hansen, AM; Mowery, SA; Olsen, AK; Perez-Tilve, D; Premdjee, B | 1 |
| Birkenfeld, AL; Eckstein, SS; Fritsche, A; Fritsche, L; Häring, HU; Heni, M; Hörber, S; Peter, A; Prystupa, K; Wagner, R | 1 |
| Biancolin, AD; Brubaker, PL; Jeong, H; Mak, KWY; Yuan, Z | 1 |
| Horowitz, M; Jalleh, RJ; Jones, KL; Rayner, CK | 1 |
| Brown, T; Carlson, OD; Clark, JM; Egan, JM; Langan, S; Lee, CJ; Schweitzer, M | 1 |
| Chatterjee, D; Goswami, A; Hiray, A; Jain, A; Kate, AS; Vhora, N | 1 |
| Chapman, I; Giezenaar, C; Horowitz, M; Jones, KL; Lange, K; Oberoi, A; Rigda, RS; Soenen, S | 1 |
| Angelidi, AM; Gavrieli, A; Kokkinos, A; Mantzoros, CS; Perakakis, N; Tentolouris, N; Tsilingiris, D; Yannakoulia, M | 1 |
| Farhat, N; George, J; Thomas, E | 1 |
| Biancolin, AD; Brubaker, PL; Jeong, H; Martchenko, A; Srikrishnaraj, A | 1 |
| -Mannan, AD; Aburub, A; ElSayed, MEH; Estwick, S; Patel, PJ; Sperry, A; Tran, H | 1 |
| Conlon, JM; Flatt, PR; Irwin, N; Klempel, N; Thomas, K | 1 |
| Abdelaal, M; Docherty, NG; Elliott, JA; Flatt, PR; Khan, D; Le Roux, CW; Moffett, CR; Naughton, V; Sridhar, A | 1 |
| Buralkina, NA; Chuprynin, VD; Chursin, VV; Krasnyi, AM; Pavlovich, SV; Sadekova, AA; Smolnova, TY; Sukhikh, GT; Yarotskaya, E | 1 |
| Aguilar-Ballester, M; González-Navarro, H; Hurtado-Genovés, G; Jiménez-Martí, E; Martínez-Hervás, S | 1 |
| Akita, T; Kimura, R; Nagai, M; Oda, Y; Oka, JI; Shimamura, M; Tezuka, A; Washizu, K; Yamashita, C | 1 |
| Fridh, MK; Gerbek, T; Hartmann, B; Holst, JJ; Mathiesen, S; Müller, K; Nissen, AA; Soerum, ME; Sørensen, K; Vadmand, AC | 1 |
| Li, R; Zhang, R; Zhao, Q | 1 |
| Javeed, N; Sen, S | 1 |
| Cea Salazar, V; Fasul, S; Krieger, JP; López-Ferreras, L; Rinaman, L; Skibicka, KP; Valderrama Pena, N; Zheng, H | 1 |
| Cox, JM; Konrad, RJ; Ming, W; Siegel, RW; Umberger, TS | 1 |
| Andreassen, KV; Henriksen, K; Karsdal, MA; Kayed, A; Khan, S; Melander, SA | 1 |
| Grayson, BE; Harris, KK; Pride, Y; Smith, AM; Welch, BA | 1 |
| Atkinson, G; Betts, JA; Carter, S; Gonzalez, JT; Holst, JJ; Koumanov, F; Watkins, JD | 1 |
| Rehfeld, JF | 1 |
| Cobelli, C; Dalla Man, C; Egan, AM; Farahani, RA; Laurenti, MC; Vella, A; Welch, AA | 1 |
| Lefèbvre, PJ; Scheen, AJ | 1 |
| Horowitz, M; Huang, W; Jones, KL; Rayner, CK; Wewer Albrechtsen, NJ; Wu, T; Xie, C | 1 |
| Bhawal, R; Chen, W; Jing, H; Lidan, S; Qiang, Z; Qianqian, Z; Wenxi, W; Zhihong, Y | 1 |
| Capucho, AM; Conde, SV; Eickhoff, H; Marques, D; Matafome, P; Rosendo-Silva, D; Sacramento, JF; Seiça, R; Simões, F; Tavares, G | 1 |
| Cummings, BP; Holm, SM; Holter, MM; Loftus, JP; Peng, SA | 1 |
| Basilico, S; Buscemi, S; Carruba, M; Castelvecchio, S; Cinti, S; Corsi Romanelli, MM; Di Vincenzo, A; Dozio, E; Dubini, C; Giordano, A; Goldberger, JJ; Iacobellis, G; Malavazos, AE; Menicanti, L; Meregalli, C; Morricone, L; Nisoli, E; Ragni, M; Ruocco, C; Secchi, F; Spagnolo, P; Vianello, E | 1 |
| Cui, X; Gu, L; Hong, T; Jiang, Y; Li, F; Lin, X; Wang, D; Wang, K; Wei, R; Wei, T; Yang, J; Yang, K | 1 |
| Csanalosi, M; Kabisch, S; Kemper, M; Keyhani-Nejad, F; Markova, M; Meyer, NMT; Pfeiffer, AFH; Pivovarova-Ramich, O; Rohn, S; Schäfer, SM; Schuppelius, B; Zhang, J | 1 |
| Arora, S; Kalra, S; Kapoor, N | 1 |
| Birkenfeld, AL; Bornstein, SR; Hoffmann, C; Mantzoros, CS; Perakakis, N; Schwarz, PE; Solimena, M; Wolfrum, C | 1 |
| Müller, TD; Novikoff, A | 1 |
| Flatt, PR; Irwin, N; Khan, D; Moffett, RC; Sridhar, A | 1 |
| Ambery, P; Iqbal, N; Logue, J; Mallappa, A; Sjöström, CD | 1 |
| Doggrell, SA | 1 |
| Barber, TM; Hanson, P; Kyrou, I; Pelling, M; Randeva, H; Statham, L | 1 |
| Golovina, EL; Grishkevich, IR; Kudlay, DA; Matveeva, MV; Podchinenova, DV; Samoilova, IG; Vaizova, OE | 1 |
| Ahrén, B; Nogueiras, R; Tschöp, M | 1 |
| Al-Ghurayr, NK; Al-Mowalad, AM; Al-Shehri, SS; AlHarbi, SM; AlShaikh, AA; Alsufiani, HM; Ashi, HM; Omar, UM | 1 |
| Robertson, RP | 1 |
| Argyrakopoulou, G; Bontozoglou, N; Kalra, B; Kokkinos, A; Konstantinidou, SK; Kouvari, M; Kumar, A; Kumar, M; Kyriakopoulou, K; Mantzoros, CS; Simati, S; Stefanakis, K | 1 |
| Nauck, MA; Nogueiras, R; Tschöp, MH | 1 |
| Alsina-Fernandez, J; Coskun, T; Du, Y; Haupt, A; Hemmingway, A; Loh, MT; Milicevic, Z; O'Farrell, L; Qu, H; Urva, S | 1 |
| Deane, A; Horowitz, M; Jalleh, RJ; Jones, KL; Plummer, MP; Umapathysivam, MM | 1 |
| Bhattacharya, S; Okoh, GI; Thompson, D; Vishnoi, S; Walsh, EM | 1 |
| Kampmann, U; Ovesen, PG; Rittig, N; Smedegaard, S; Støvring, H | 1 |
| Gasbjerg, LS; Holst, JJ; Knop, FK; Meier, JJ; Rosenkilde, MM | 1 |
| Baker, D; Corkill, DJ; Gomes Dos Santos, AL; Hornigold, DC; Kinna, S; Liang, L; Naylor, J; Ouberai, MM; Welland, ME | 1 |
| Cortes, D; de Knegt, VE; Gluud, LL; Halkjær, SI; Jensen, JB; Kallemose, T; Petersen, AM; Wewer Albrechtsen, NJ | 1 |
| Andrews, RC; Bowman, P; Flanagan, SE; Hammersley, S; Hartmann, B; Hattersley, AT; Holst, JJ; Knight, BA; Leveridge, M; McDonald, TJ; Patel, KA; Shepherd, MH; Shields, BM; Spaull, SR | 1 |
| Campbell, JE; Schuit, F | 1 |
| Aydin, BK; Bergsten, P; Cerenius, SY; Chowdhury, A; Ciba, I; Forslund, A; Gjessing, ES; Gomahr, J; Heu, V; Kristinsson, H; Manell, H; Mörwald, K; Stenlid, R; Weghuber, D; Wen, Q | 1 |
302 review(s) available for glucagon and glucagon-like peptide 1
| Article | Year |
|---|---|
Glucagon-like peptide-1, a new hormone of the entero-insular axis.
Topics: Amino Acid Sequence; Animals; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Islets of Langerhans; Molecular Sequence Data; Pancreatic Hormones; Peptides; Proglucagon; Protein Precursors; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Glucagon | 1992 |
Glucagon-like peptide-1(7-37)/(7-36)amide is a new incretin.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Galanin; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Intestinal Mucosa; Islets of Langerhans; Peptide Fragments; Peptides; Proinsulin; Protein Precursors; Somatostatin | 1992 |
Entero-insular axis and diabetes mellitus.
Topics: Animals; Cholecystokinin; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Intestines; Islets of Langerhans; Peptide Fragments | 1992 |
[Various molecular mechanisms involved in the pathogenesis of type II diabetes and their potential therapeutic importance].
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Monosaccharide Transport Proteins; Peptide Fragments; Protein Precursors; RNA, Messenger; Transcription, Genetic | 1992 |
Glucagon-like peptide-1(7-36) amide is a new incretin/enterogastrone candidate.
Topics: Animals; Brain; Digestive System; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, Glucagon | 1991 |
[The entero-insular axis: the new incretin candidate glucagon-like peptide-1(7-36)amide (GLP-1(7-36))amide].
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Structure-Activity Relationship; Swine | 1988 |
New developments in the incretin concept.
Topics: Animals; Feedback; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Insulin; Insulin Secretion; Liver; Peptide Fragments | 1985 |
Gastric inhibitory polypeptide.
Topics: Adipose Tissue; Amino Acid Sequence; Animals; Diabetes Mellitus; Gastric Acid; Gastric Inhibitory Polypeptide; Gastrins; Gastrointestinal Diseases; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Insulin; Pancreatitis; Pepsin A; Peptide Fragments; Peptides; Proinsulin; Radioimmunoassay; Salivation; Splanchnic Circulation | 1982 |
GIP, incretin and gastrointestinal disease.
Topics: Animals; Blood Glucose; Celiac Disease; Digestive System; Duodenal Ulcer; Gastric Inhibitory Polypeptide; Gastrointestinal Diseases; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Ileum; Insulin; Intestine, Small; Islets of Langerhans; Jejunum; Peptide Fragments; Peptides; Vagotomy | 1983 |
Gastrointestinal peptides--rôle in pathophysiology and disease.
Topics: Autonomic Nervous System; Duodenal Ulcer; Endocrine Glands; Gastric Inhibitory Polypeptide; Gastrins; Gastrointestinal Diseases; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Intestinal Absorption; Peptide Fragments; Peptides | 1982 |
[Factors with insulin-like effects: IGF-I and GLP-1].
Topics: Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Insulin-Like Growth Factor I; Pancreatic Hormones; Peptide Fragments; Peptides; Protein Precursors | 1995 |
Cell and molecular biology of the incretin hormones glucagon-like peptide-I and glucose-dependent insulin releasing polypeptide.
Topics: Amino Acid Sequence; Animals; Gastric Inhibitory Polypeptide; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Humans; Islets of Langerhans; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Protein Processing, Post-Translational; Signal Transduction | 1995 |
[Diet therapy: role of incretin and dietary fibers].
Topics: Diabetes Mellitus; Diet Therapy; Dietary Fiber; Dietetics; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Peptide Fragments | 1995 |
The genetics of non-insulin-dependent diabetes mellitus.
Topics: Amyloid; Animals; Base Sequence; Carrier Proteins; Chromosome Mapping; Cloning, Molecular; Diabetes Mellitus, Type 2; DNA, Mitochondrial; Fatty Acid-Binding Protein 7; Fatty Acid-Binding Proteins; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Glucose Transporter Type 4; Glycogen Synthase; Humans; Insulin; Insulin Resistance; Islet Amyloid Polypeptide; Molecular Sequence Data; Monosaccharide Transport Proteins; Muscle Proteins; Neoplasm Proteins; Peptide Fragments; Protein Precursors; Receptor, Insulin; Selection, Genetic; Tumor Suppressor Proteins | 1995 |
[Incretin research in the development of new strategies of diabetes therapy].
Topics: Amino Acid Sequence; Blood Glucose; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon | 1995 |
Glucagonlike peptide 1: a newly discovered gastrointestinal hormone.
Topics: Blood Glucose; Diabetes Mellitus; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Liver; Peptides | 1994 |
[GLP-1 and the control of insulin secretion].
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors; Signal Transduction; Structure-Activity Relationship | 1994 |
["Glucagon-like peptide I": a therapeutic alternative for diabetes mellitus?].
Topics: Animals; B-Lymphocytes; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1994 |
The incretin notion and its relevance to diabetes.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Molecular Sequence Data; Peptide Fragments; Protein Precursors | 1993 |
[Dysfunction of the pancreatic beta cells observed in non-insulin-dependent diabetes].
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Insulin; Insulin Secretion; Islets of Langerhans; Monosaccharide Transport Proteins; Peptide Fragments; Protein Precursors | 1993 |
Inter-organ communication between intestine and liver in vivo and in vitro.
Topics: Animals; Cell Communication; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glutamine; Humans; Intestines; Liver; Peptide Fragments; Perfusion; Protein Precursors | 1993 |
Glucagon-like peptide-I and the control of insulin secretion in the normal state and in NIDDM.
Topics: Animals; Cloning, Molecular; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Peptides; Protein Precursors; Signal Transduction | 1993 |
Glucagon and its family revisited.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus; Gene Expression Regulation; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Homeostasis; Humans; Hypoglycemia; Islets of Langerhans; Molecular Sequence Data; Peptide Fragments; Protein Precursors | 1995 |
Glucagon-like peptide-1 and control of insulin secretion.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Secretory Rate; Signal Transduction | 1995 |
Central glucagon-like peptide-I in the control of feeding.
Topics: Animals; Brain; Feeding Behavior; Genes, fos; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Hyperglycemia; Hyperinsulinism; Neurons; Peptide Fragments; Protein Precursors; Rats; Rats, Zucker; Receptors, Glucagon; Venoms | 1996 |
The metabolic role of GIP: physiology and pathology.
Topics: Adipocytes; Animals; Diabetes Mellitus, Type 2; Diet; Digestive System Physiological Phenomena; Energy Metabolism; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Mice; Mice, Inbred NOD; Models, Biological; Obesity; Organ Specificity; Peptide Fragments; Protein Precursors; Rats; Rats, Zucker; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1996 |
Regulatory peptides in the control of metabolism during starvation and exercise.
Topics: Animals; Eating; Energy Metabolism; Exercise; Exercise Test; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Hormones; Humans; Oxygen Consumption; Peptide Fragments; Peptides; Protein Precursors; Secretin; Starvation; Vasoactive Intestinal Peptide | 1996 |
Glucagon, glucagon-like peptide-1 and their receptors: an introduction.
Topics: Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 1996 |
Glucagon and GLP-1 receptors: lessons from chimeric ligands and receptors.
Topics: Amino Acid Sequence; Glucagon; Glucagon-Like Peptide 1; Ligands; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Recombinant Fusion Proteins | 1996 |
Molecular mechanism underlying glucagon-like peptide 1 induced calcium mobilization from internal stores in insulin-secreting beta TC3 cells.
Topics: Calcium; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Molecular Biology; Peptide Fragments; Protein Precursors | 1996 |
Distribution of GLP-1 and PACAP receptors in human tissues.
Topics: Adipose Tissue; Amino Acid Sequence; Brain Chemistry; Digestive System; Glucagon; Glucagon-Like Peptide 1; Humans; Liver; Molecular Sequence Data; Muscle, Skeletal; Myocardium; Pancreas; Peptide Fragments; Protein Precursors; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone | 1996 |
In vitro insulinomimetic [corrected] effects of GLP-1 in liver, muscle and fat.
Topics: Adipose Tissue; Animals; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Liver; Muscles; Peptide Fragments; Protein Precursors | 1996 |
Nutrient-induced secretion and metabolic effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1.
Topics: Adaptation, Physiological; Adipose Tissue; Animals; Coronary Disease; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Obesity; Peptide Fragments | 1996 |
Therapeutic potential of glucagon-like peptide 1 in type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Infusions, Intravenous; Injections, Subcutaneous; Peptide Fragments; Postprandial Period; Protein Precursors | 1996 |
GLP-1 in NIDDM.
Topics: Animals; Blood Glucose; Brain; Diabetes Mellitus, Type 2; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Intestine, Small; Islets of Langerhans; Pancreas; Peptide Fragments; Protein Precursors | 1996 |
Regulation, perturbation, and correction of metabolic events in pancreatic islets.
Topics: Adenosine; Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Glycerolphosphate Dehydrogenase; Hexoses; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mitochondria; Oxidative Phosphorylation; Peptide Fragments; Protein Precursors; Sulfonylurea Compounds | 1996 |
Human studies with glucagon-like-peptide-1: potential of the gut hormone for clinical use.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Drug Design; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors | 1996 |
New treatments for patients with type 2 diabetes mellitus.
Topics: Amyloid; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Islet Amyloid Polypeptide; Peptide Fragments; Protein Precursors; Sulfonylurea Compounds | 1996 |
Endoprotease regulation of miniglucagon production.
Topics: Amino Acid Sequence; Animals; Endopeptidases; Female; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Intestine, Small; Islets of Langerhans; Male; Molecular Sequence Data; Muscle, Smooth; Organ Specificity; Peptide Biosynthesis; Peptide Fragments; Peptides; Protein Precursors; Protein Processing, Post-Translational | 1996 |
Signal transduction of PACAP and GLP-1 in pancreatic beta cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Cyclic GMP; Glucagon; Glucagon-Like Peptide 1; Ion Channels; Islets of Langerhans; Membrane Potentials; Models, Biological; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Rats; Signal Transduction | 1996 |
Pancreatic beta-cell receptors and G proteins coupled to adenylyl cyclase.
Topics: Adenylyl Cyclases; Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; GTP-Binding Proteins; Humans; Islets of Langerhans; Macromolecular Substances; Organ Specificity; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Signal Transduction | 1996 |
On the effects of glucagon-like peptide-1 on blood glucose regulation in normal and diabetic subjects.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 1; Digestive System; Digestive System Physiological Phenomena; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Islets of Langerhans; Peptide Fragments; Proglucagon; Protein Precursors; Protein Processing, Post-Translational; Reference Values | 1996 |
Enteroglucagon.
Topics: Animals; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Intestinal Mucosa; Oxyntomodulin; Peptide Fragments; Peptides; Proglucagon; Protein Precursors | 1997 |
The intestine, an endocrine organ.
Topics: Animals; Cholecystokinin; Endocrine Glands; Gastric Inhibitory Polypeptide; Gastric Mucosa; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Humans; Intestinal Mucosa; Intestines; Pancreas; Peptide Fragments; Protein Precursors; Somatostatin | 1997 |
[Glucagon-like peptide-1 (GLP-1) receptor gene].
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 1997 |
Glucagon-like peptide-1 structure, function and potential use for NIDDM.
Topics: Diabetes Mellitus, Type 2; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 1997 |
Control of appetite--the role of glucagon-like peptide-1 (7-36) amide.
Topics: Adipocytes; Animals; Appetite Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Neurotransmitter Agents; Obesity; Peptide Fragments | 1997 |
Cellular regulation of islet hormone secretion by the incretin hormone glucagon-like peptide 1.
Topics: Animals; Calcium; Diabetes Mellitus, Type 2; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Ion Channels; Islets of Langerhans; Pancreatic Hormones; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 1998 |
Glucagon-like peptides.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Humans; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon | 1998 |
Surgical aspect of enteroinsular axis after gastrointestinal surgery with reference to incretin secretion.
Topics: Digestive System Surgical Procedures; Dumping Syndrome; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Neurotransmitter Agents; Pancreas; Peptide Fragments; Postoperative Complications | 1998 |
Dietary interventions in noninsulin-dependent diabetes mellitus: new approaches.
Topics: Cholecystokinin; Diabetes Mellitus, Type 2; Eating; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 1998 |
[GLP-1 (7-36) amide [GLIP-glucagon like insulinotropic peptide] as a potential treatment for NIDDM].
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Peptide Fragments | 1998 |
Glucagon-like peptide-1 (GLP-1): a gut hormone of potential interest in the treatment of diabetes.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Molecular Sequence Data; Peptide Fragments; Proglucagon; Protein Precursors; Signal Transduction | 1998 |
Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Peptides; Protease Inhibitors; Protein Precursors | 1998 |
Glucagon-like peptide 1 (GLP-1): a potent gut hormone with a possible therapeutic perspective.
Topics: Animals; Cerebral Ventricles; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Feeding Behavior; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Models, Biological; Peptide Fragments; Proinsulin; Protein Precursors | 1998 |
Glucose action 'beyond ionic events' in the pancreatic beta cell.
Topics: Adenosine Triphosphate; Animals; Calcium; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Potassium Channels; Protein Precursors; Rats | 1998 |
Stimulatory transducing systems in pancreatic islet cells.
Topics: Animals; Cytoplasmic Granules; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; GTP-Binding Proteins; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Peptides; Receptors, Glucagon; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Receptors, Vasoactive Intestinal Peptide; Rodentia; Signal Transduction | 1998 |
Is there appetite after GLP-1 and PACAP?
Topics: Animals; Appetite; Appetite Depressants; Digestive System Physiological Phenomena; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Homeostasis; Humans; Hypothalamus; Islets of Langerhans; Models, Biological; Neuropeptides; Obesity; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Receptors, Glucagon | 1998 |
On the treatment of diabetes mellitus with glucagon-like peptide-1.
Topics: Administration, Oral; Animals; Appetite Depressants; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Peptide Fragments; Protein Precursors | 1998 |
Glucagon-like peptide-1 (7-36) amide as a novel neuropeptide.
Topics: Animals; Brain; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Rats; Receptors, Glucagon | 1998 |
Is glucagon-like peptide 1 an incretin hormone?
Topics: Animals; Diabetes Mellitus, Type 2; Digestion; Gastric Emptying; Gastrointestinal Hormones; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 1999 |
Encapsulated, genetically engineered cells, secreting glucagon-like peptide-1 for the treatment of non-insulin-dependent diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Genetic Engineering; Glucagon; Glucagon-Like Peptide 1; Humans; Membranes, Artificial; Mice; Mutation; Peptide Fragments; Protein Precursors | 1999 |
Ileal [correction of ilial] transposition and enteroglucagon/GLP-1 in obesity (and diabetic?) surgery.
Topics: Animals; Biliopancreatic Diversion; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Ileum; Obesity, Morbid; Peptide Fragments; Protein Precursors; Rats | 1999 |
Glucagon-like peptide-1, a gastrointestinal hormone with a pharmaceutical potential.
Topics: Amino Acid Sequence; Animals; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Molecular Sequence Data; Peptide Fragments; Protein Precursors | 1999 |
The use of insulin secretagogues in the treatment of type 2 diabetes.
Topics: Acarbose; Carbamates; Chromans; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Metformin; Peptide Fragments; Piperidines; Protein Precursors; Risk Factors; Sulfonylurea Compounds; Thiazoles; Thiazolidinediones; Troglitazone | 1999 |
The regulatory role of leptin in food intake.
Topics: Animals; Cholecystokinin; Corticotropin-Releasing Hormone; Eating; Glucagon; Glucagon-Like Peptide 1; Humans; Leptin; Nerve Tissue Proteins; Neuropeptide Y; Neurosecretory Systems; Peptide Fragments; Pro-Opiomelanocortin; Protein Precursors | 1998 |
Present and potential future use of gene therapy for the treatment of non-insulin dependent diabetes mellitus (Review).
Topics: Adult; Animals; Antigens, Neoplasm; Biomarkers, Tumor; Blood Glucose; Cell Transplantation; Diabetes Mellitus, Type 2; Gene Expression Regulation; Genes, Synthetic; Genetic Therapy; Genetic Vectors; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Glucose Transporter Type 2; Homeodomain Proteins; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Lectins, C-Type; Mice; Middle Aged; Monosaccharide Transport Proteins; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pancreatitis-Associated Proteins; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Proteins; Rats; Trans-Activators | 1999 |
Coordination of cAMP signaling events through PKA anchoring.
Topics: A Kinase Anchor Proteins; Adaptor Proteins, Signal Transducing; Amino Acid Motifs; Animals; Binding Sites; Calcium Channels, L-Type; Carrier Proteins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Membrane Proteins; Peptide Fragments; Protein Precursors | 2000 |
The glucagon-like peptides.
Topics: Amino Acid Sequence; Animals; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors | 1999 |
[Hepatogenic diabetes--the current concepts of its pathophysiology and therapy].
Topics: Diabetes Mellitus; Diabetes Mellitus, Type 2; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Hypoglycemic Agents; Insulin Resistance; Liver; Liver Diseases; Peptide Fragments; Receptor, Insulin | 1999 |
Targeted gene disruption in endocrine research--the case of glucagon-like peptide-1 and neuroendocrine function.
Topics: Animals; Gene Deletion; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Mice; Mice, Knockout; Neurosecretory Systems; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 2000 |
Glucagon-like peptide-1 (7-36) amide: a central regulator of satiety and interoceptive stress.
Topics: Animals; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Neurotransmitter Agents; Peptide Fragments; Satiety Response; Stress, Psychological | 1999 |
Research advances in the treatment of type 2 diabetes mellitus.
Topics: Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Peptide Fragments; Protein Kinase C; Protein Precursors; Research; Thiazoles; Thiazolidinediones | 1999 |
[GLP-1 (glucagon-like peptide 1)].
Topics: Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protein Precursors | 1999 |
Kinetic analysis of enzymatic and nonenzymatic degradation of peptides by MALDI-TOFMS.
Topics: Animals; Dipeptidyl Peptidase 4; Flavobacterium; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Kinetics; Peptide Fragments; Peptides; Prolyl Oligopeptidases; Serine Endopeptidases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2000 |
New approaches in the treatment of type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemic Agents; Liver; Molecular Structure; Peptide Fragments; Protein Precursors; Protein Tyrosine Phosphatases; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Receptors, Glucagon; Thiazoles; Thiazolidinediones; Transcription Factors | 2000 |
Singular contributions of fish neuroendocrinology to mammalian regulatory peptide research.
Topics: Amino Acid Sequence; Animals; Corticotropin-Releasing Hormone; Fishes; Glucagon; Glucagon-Like Peptide 1; Glycoproteins; Hormones; Humans; Mammals; Molecular Sequence Data; Peptide Fragments; Phylogeny; Protein Precursors; Urocortins; Urotensins; Vertebrates | 2000 |
Gut hormones as pharmaceuticals. From enteroglucagon to GLP-1 and GLP-2.
Topics: Animals; Digestive System; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Peptide Fragments; Peptides; Protein Precursors | 2000 |
Effects of fructans-type prebiotics on lipid metabolism.
Topics: Animals; Blood Glucose; Fatty Acids; Fructans; Gene Expression Regulation, Enzymologic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypolipidemic Agents; Insulin; Lipid Metabolism; Lipoproteins; Liver; Neurotransmitter Agents; Oligosaccharides; Peptide Fragments; Rats; Triglycerides | 2001 |
Minireview: the glucagon-like peptides.
Topics: Animals; Central Nervous System; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Intestinal Diseases; Intestines; Pancreas; Peptide Fragments; Peptides; Protein Precursors | 2001 |
Molecular evolution of proglucagon.
Topics: Animals; Evolution, Molecular; Genes; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Peptide Fragments; Peptides; Phylogeny; Proglucagon; Protein Precursors | 2001 |
New developments in the biology of the glucagon-like peptides GLP-1 and GLP-2.
Topics: Animals; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; In Vitro Techniques; Intestinal Diseases; Intestinal Mucosa; Islets of Langerhans; Mice; Mice, Knockout; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Signal Transduction | 2000 |
New pharmacological development (alpha glucosidase inhibitors, amylin analogues, GLP-1, thiozolidinediones, short acting insulin analogues).
Topics: Amyloid; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insulin; Islet Amyloid Polypeptide; Peptide Fragments; Protein Precursors; Rosiglitazone; Thiazoles; Thiazolidinediones | 2001 |
Glucagon-like peptide-1.
Topics: Age Factors; Aged; Aging; Animals; Cell Line; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Glucose Transporter Type 2; Homeodomain Proteins; Humans; Insulin; Islets of Langerhans; Models, Biological; Monosaccharide Transport Proteins; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Trans-Activators; Up-Regulation | 2001 |
Glucagon-like peptide-1. Gastrointestinal function and possible mechanism of action.
Topics: Diabetes Mellitus; Digestive System; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protein Precursors | 2001 |
The entero-insular axis in type 2 diabetes--incretins as therapeutic agents.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Intestines; Islets of Langerhans; Peptide Fragments; Protein Precursors | 2001 |
Development of glucagon-like peptide-1-based pharmaceuticals as therapeutic agents for the treatment of diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Drug Delivery Systems; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Technology, Pharmaceutical; Venoms | 2001 |
Control of glucose homeostasis by incretin hormones.
Topics: Animals; Blood Glucose; Energy Metabolism; Gastrointestinal Hormones; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Gluconeogenesis; Glucose; Homeostasis; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Liver; Peptide Fragments | 1999 |
A meta-analysis of the effect of glucagon-like peptide-1 (7-36) amide on ad libitum energy intake in humans.
Topics: Adult; Appetite; Cross-Over Studies; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hunger; Infusions, Intravenous; Injections, Intravenous; Male; Obesity; Peptide Fragments; Randomized Controlled Trials as Topic; Satiety Response | 2001 |
Incretin hormones--an update.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Insulin; Insulin Secretion; Intestinal Mucosa; Peptide Fragments; Protein Precursors | 2001 |
Gut adaptation and the glucagon-like peptides.
Topics: Adaptation, Physiological; Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Intestinal Diseases; Intestines; Mice; Peptide Fragments; Peptides; Protein Precursors; Rats; Short Bowel Syndrome | 2002 |
Glucose tolerance, glucose utilization and insulin secretion in ageing.
Topics: Aging; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Humans; Insulin; Islets of Langerhans; Liver; Peptide Fragments | 2002 |
The multifaceted potential of glucagon-like peptide-1 as a therapeutic agent.
Topics: Animals; Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Administration Routes; Gastric Emptying; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Intestine, Small; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Receptors, Glucagon; Satiety Response; Signal Transduction | 2002 |
Ups and downs for neuropeptides in body weight homeostasis: pharmacological potential of cocaine amphetamine regulated transcript and pre-proglucagon-derived peptides.
Topics: Adipose Tissue; Animals; Body Weight; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Homeostasis; Humans; Hypothalamus; Nerve Tissue Proteins; Neurons; Neuropeptides; Peptide Fragments; Peptides; Protein Precursors | 2002 |
Glucagon-like peptide 1 as a regulator of food intake and body weight: therapeutic perspectives.
Topics: Animals; Body Weight; Eating; Glucagon; Glucagon-Like Peptide 1; Humans; Obesity; Peptide Fragments; Protein Precursors | 2002 |
Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; History, 20th Century; History, 21st Century; Peptide Fragments; Protease Inhibitors; Protein Precursors | 2002 |
[A therapeutic option for type-2 diabetes. The incretion hormone GLP-1].
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Peptide Fragments; Protein Precursors | 2002 |
Gastric inhibitory polypeptide analogues: do they have a therapeutic role in diabetes mellitus similar to that of glucagon-like Peptide-1?
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 2002 |
Gastric inhibitory polypeptide: the neglected incretin revisited.
Topics: Adipose Tissue; Amino Acid Sequence; Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Lipids; Models, Biological; Molecular Sequence Data; Pancreatic Hormones; Peptide Fragments; Postprandial Period; Protein Precursors; Secretin; Sequence Homology, Amino Acid; Stomach | 2002 |
[Review: regulation of glucose metabolism].
Topics: Animals; Blood Glucose; Diabetes Mellitus; Fasting; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucokinase; Glucose; Glucose Transporter Type 2; Glycogen; Humans; Insulin; Insulin Secretion; Intestinal Absorption; Liver; Monosaccharide Transport Proteins; Peptide Fragments; Protein Precursors | 2002 |
[Glucagon and GLP (glucagon-like peptide)].
Topics: Animals; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hyperglycemia; Peptide Fragments; Peptides; Protein Precursors | 2002 |
[Glucagon-like peptide-1 (GLP-1) receptor].
Topics: Animals; Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Peptide Fragments; Peptides; Polymorphism, Genetic; Protein Precursors; Receptors, Glucagon; Venoms | 2002 |
[Regenerative medicine in diabetes by beta cell therapy and promotion of beta cell growth and differentiation].
Topics: Animals; Antigens, Neoplasm; Betacellulin; Biomarkers, Tumor; Cell Differentiation; Cell Division; Diabetes Mellitus, Type 1; Genetic Therapy; Glucagon; Glucagon-Like Peptide 1; Humans; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Islets of Langerhans Transplantation; Lectins, C-Type; Niacinamide; Pancreatitis-Associated Proteins; Peptide Fragments; Protein Precursors; Proteins; Regeneration; Stem Cell Transplantation; Stem Cells; Tissue Engineering | 2002 |
Preclinical developments in type 2 diabetes.
Topics: Acetyl-CoA Carboxylase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; I-kappa B Kinase; Insulin Resistance; Peptide Fragments; Protein Precursors; Protein Serine-Threonine Kinases | 2002 |
[Regulation of insulin secretion by incretins].
Topics: Animals; Carrier Proteins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Guanine Nucleotide Exchange Factors; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Nuclear Proteins; Peptide Fragments | 2002 |
The multiple actions of GLP-1 on the process of glucose-stimulated insulin secretion.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Pancreas; Peptide Fragments; Protein Precursors | 2002 |
Novel peptides under development for the treatment of type 1 and type 2 diabetes mellitus.
Topics: Amyloid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Design; Exenatide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Islet Amyloid Polypeptide; Peptide Fragments; Peptides; Postprandial Period; Protein Precursors; Venoms | 2002 |
Aging and insulin secretion.
Topics: Adult; Aged; Aged, 80 and over; Aging; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Intolerance; Humans; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Middle Aged; Nutrition Surveys; Peptide Fragments | 2003 |
The glucagon-like peptides: a new genre in therapeutic targets for intervention in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Apoptosis; Brain; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Neuroprotective Agents; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 2002 |
Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors.
Topics: Alternative Splicing; Animals; Cloning, Molecular; Gastric Inhibitory Polypeptide; Genetic Diseases, Inborn; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Humans; Peptide Fragments; Peptides; Protein Precursors; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Structure-Activity Relationship | 2002 |
Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis.
Topics: Animals; Apoptosis; Cell Differentiation; Cell Division; Exocrine Glands; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Humans; Intestines; Islets of Langerhans; Peptide Fragments; Peptide Hormones; Peptides; Protein Precursors; Receptors, Glucagon; Signal Transduction | 2003 |
Insulin sensitisation in the treatment of Type 2 diabetes.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adrenergic beta-3 Receptor Agonists; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Hydroxysteroid Dehydrogenases; Hypoglycemic Agents; Insulin; Insulin Resistance; Islets of Langerhans; Metformin; Peptide Fragments; Protein Precursors; Randomized Controlled Trials as Topic; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thiazoles; Transcription Factors | 2003 |
Glucagon-like peptide 1 and gastric inhibitory polypeptide: potential applications in type 2 diabetes mellitus.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Exenatide; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Peptide Fragments; Peptides; Protease Inhibitors; Protein Precursors; Venoms | 2003 |
Implementation of GLP-1 based therapy of type 2 diabetes mellitus using DPP-IV inhibitors.
Topics: Appetite; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protease Inhibitors; Protein Precursors | 2003 |
Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both involved in regulating the metabolic stability of glucagon-like peptide-1 in vivo.
Topics: Amino Acid Sequence; Animals; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Kinetics; Mice; Molecular Sequence Data; Neprilysin; Peptide Fragments; Protease Inhibitors; Protein Precursors | 2003 |
Pancreatic and extrapancreatic effects of GLP-1.
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Pancreas; Peptide Fragments; Protein Precursors | 2002 |
[Current topics in endocrinology: incretin].
Topics: Animals; Cytokines; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Peptide Fragments | 2003 |
Central pre-proglucagon derived peptides: opportunities for treatment of obesity.
Topics: Animals; Behavior, Animal; Central Nervous System; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Obesity; Oxyntomodulin; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Receptors, Glucagon | 2003 |
NN-2211 Novo Nordisk.
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Liraglutide; Technology, Pharmaceutical | 2003 |
Enteroinsular signaling: perspectives on the role of the gastrointestinal hormones glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide in normal and abnormal glucose metabolism.
Topics: Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors; Secretory Rate; Signal Transduction | 2003 |
The glucagon-like peptides: a double-edged therapeutic sword?
Topics: Amino Acid Sequence; Animals; Brain; Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Insulin Secretion; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Venoms | 2003 |
Gut peptides and type 2 diabetes mellitus treatment.
Topics: Diabetes Mellitus, Type 2; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Islets of Langerhans; Peptide Fragments; Protein Precursors; Satiation | 2003 |
Enhancing incretin action for the treatment of type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protein Precursors | 2003 |
Glucagon-like peptide-1 synthetic analogs: new therapeutic agents for use in the treatment of diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Insulin Secretion; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Venoms | 2003 |
Clinically validated peptides as templates for de novo peptidomimetic drug design at G-protein-coupled receptors.
Topics: Complement C5a; Drug Design; Glucagon; Glucagon-Like Peptide 1; Gonadotropin-Releasing Hormone; Neurotensin; Peptide Fragments; Peptides; Protein Precursors; Receptor, Melanocortin, Type 4; Receptors, G-Protein-Coupled; Receptors, Vasopressin; Somatostatin; Urotensins | 2003 |
Glucagon-like peptide-1 and the islet beta-cell: augmentation of cell proliferation and inhibition of apoptosis.
Topics: Animals; Apoptosis; Cell Division; Glucagon; Glucagon-Like Peptide 1; Humans; Islets of Langerhans; Peptide Fragments; Protein Precursors | 2003 |
Incretins and their analogues as new antidiabetic drugs.
Topics: Animals; Diabetes Mellitus, Type 2; Drug Therapy; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Peptide Fragments; Protein Precursors | 2003 |
Pharmacology of exenatide (synthetic exendin-4): a potential therapeutic for improved glycemic control of type 2 diabetes.
Topics: Amino Acid Sequence; Animals; Cell Division; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Molecular Sequence Data; Nutritional Physiological Phenomena; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Venoms | 2004 |
Direct and indirect mechanisms regulating secretion of glucagon-like peptide-1 and glucagon-like peptide-2.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Intestinal Mucosa; Peptide Fragments; Peptides; Protein Precursors; Vagus Nerve | 2003 |
Incretins, insulin secretion and Type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 2004 |
Gut peptides in the treatment of diabetes mellitus.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Peptide Fragments; Peptide Hormones; Protease Inhibitors; Protein Precursors; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 2004 |
Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system.
Topics: Animals; Apoptosis; Cell Division; Central Nervous System; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Intestines; Pancreas; Peptide Fragments; Peptides; Protein Precursors | 2004 |
Emerging therapies: controlling glucose homeostasis, immunotherapy, islet transplantation, gene therapy, and islet cell neogenesis and regeneration.
Topics: Blood Glucose; Cell Differentiation; Cell Division; Diabetes Mellitus, Type 1; Exenatide; Genetic Therapy; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Immunotherapy; Islets of Langerhans; Islets of Langerhans Transplantation; Peptide Fragments; Peptides; Protein Precursors; Stem Cells; Venoms | 2004 |
Gastrointestinal satiety signals III. Glucagon-like peptide 1, oxyntomodulin, peptide YY, and pancreatic polypeptide.
Topics: Digestive System; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Oxyntomodulin; Pancreatic Polypeptide; Peptide Fragments; Peptide YY; Protein Precursors; Satiety Response; Signal Transduction | 2004 |
Potential therapies mimicking the effects of glucagon-like peptide-1 for the treatment of type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Liraglutide; Peptide Fragments; Peptides; Protein Precursors; Venoms | 2004 |
Novel strategies for the pharmacological management of type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Peptide Fragments; Protein Precursors; Receptors, Cytoplasmic and Nuclear; Sulfonylurea Compounds; Transcription Factors | 2004 |
Gastro-intestinal hormones GIP and GLP-1.
Topics: Animals; Diabetes Mellitus; Digestive System Physiological Phenomena; Dipeptidyl Peptidase 4; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 2004 |
The potential role of glucagon-like peptide 1 in diabetes.
Topics: Animals; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Injections, Intravenous; Injections, Subcutaneous; Insulin; Peptide Fragments; Protein Precursors | 2004 |
Glucagon-like peptide 1 agonists and the development and growth of pancreatic beta-cells.
Topics: Animals; Cell Division; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Islets of Langerhans; Islets of Langerhans Transplantation; Peptide Fragments; Protein Precursors | 2004 |
Glucagon-like peptide 1: evolution of an incretin into a treatment for diabetes.
Topics: Animals; Diabetes Mellitus, Type 1; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Peptide Fragments; Protein Precursors | 2004 |
[Future targets in the treatment of type 2 diabetes].
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Forecasting; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycated Hemoglobin; Glycogen Synthase Kinase 3; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipid Peroxidation; Metabolic Syndrome; Mice; Oxazines; Peptide Fragments; Phenylpropionates; Protein Precursors; Rats; Receptor, Insulin; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Signal Transduction; Thiazolidinediones; Transcription Factors | 2004 |
Treatment of type 2 diabetes mellitus with agonists of the GLP-1 receptor or DPP-IV inhibitors.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Afferent Pathways; Animals; Appetite; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Drug Therapy, Combination; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycoproteins; Humans; Hypoglycemic Agents; Hypothalamus; Insulin; Insulin Secretion; Intestinal Mucosa; Islets of Langerhans; Liraglutide; Lizards; Maleimides; Mice; Mice, Knockout; Mice, Obese; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Rats; Rats, Zucker; Receptors, Glucagon; Venoms | 2004 |
The gastrointestinal tract and glucose tolerance.
Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Energy Metabolism; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 2004 |
[Glucagon-like peptide-1(GLP-1)].
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protein Precursors | 2004 |
Pramlintide for the treatment of insulin-requiring diabetes mellitus: rationale and review of clinical data.
Topics: Amyloid; Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 1; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Islet Amyloid Polypeptide; Peptide Fragments; Protein Precursors | 2004 |
Glucagon-like peptide 1 (GLP-1) and eating.
Topics: Animals; Antibodies; Digestive System; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 2004 |
[Glucagon 2004: homage to Roger Assan].
Topics: Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; History, 20th Century; Humans; Peptide Fragments; Peptides; Protein Precursors | 2004 |
[GIP and GLP-1: multiplicity of regulator mechanisms for insulin secretion].
Topics: Animals; Cell Differentiation; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Knockout; Peptide Fragments; Protein Precursors; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Signal Transduction | 2004 |
[Miniglucagon: is the precursor a traitor to its family or a genius? ].
Topics: Amino Acid Sequence; Animals; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Islets of Langerhans; Molecular Sequence Data; Peptide Fragments; Protein Precursors | 2004 |
A new Alzheimer's disease interventive strategy: GLP-1.
Topics: Alzheimer Disease; Animals; Calcium; Cell Death; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Models, Biological; Peptide Fragments; Protein Precursors; Signal Transduction | 2004 |
Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Neurosecretory Systems; Peptide Fragments; Peptide Hormones; Protein Precursors | 2004 |
Glucagon-like peptide-1: the basis of a new class of treatment for type 2 diabetes.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Structure-Activity Relationship | 2004 |
[Endocrine system of the gastrointestinal tract. Pathophysiology with a clinical view].
Topics: Digestive System Physiological Phenomena; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protein Precursors; Somatostatin | 2004 |
Are we closer to finding the treatment for type 2 diabetes mellitus in morbid obesity? Are the incretins the key to success?
Topics: Acyl Coenzyme A; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Lipolysis; Obesity, Morbid; Peptide Fragments; Peptide Hormones; Peptide YY; Protein Precursors | 2004 |
Therapeutic strategies based on glucagon-like peptide 1.
Topics: Amino Acid Sequence; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Molecular Sequence Data; Peptide Fragments; Protein Precursors | 2004 |
Gut hormones and the control of appetite.
Topics: Animals; Appetite Regulation; Cholecystokinin; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Leptin; Obesity; Oxyntomodulin; Pancreatic Polypeptide; Peptide Fragments; Peptide Hormones; Peptide YY; Protein Precursors | 2004 |
Gut-derived incretin hormones and new therapeutic approaches.
Topics: Diabetes Mellitus, Type 2; Exenatide; Female; Follow-Up Studies; Forecasting; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Peptide Fragments; Peptides; Protein Precursors; Randomized Controlled Trials as Topic; Risk Assessment; Treatment Outcome; Venoms | 2004 |
[Analogs of glucagon-like peptide-1 (GLP-1): an old concept as a new treatment of patients with diabetes mellitus type 2].
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Peptide Fragments; Protein Precursors | 2004 |
Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protease Inhibitors; Protein Precursors; United Kingdom | 2004 |
Clinical endocrinology and metabolism. Glucagon-like peptide-1 and glucagon-like peptide-2.
Topics: Animals; Cardiovascular Physiological Phenomena; Diabetes Mellitus, Type 2; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucose; Humans; Nervous System Physiological Phenomena; Peptide Fragments; Peptides; Protein Precursors | 2004 |
[Oral diabetes treatment. Which substance is indicated at which time?].
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Germany; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Metformin; Obesity; Peptide Fragments; Peptides; Practice Guidelines as Topic; Practice Patterns, Physicians'; Treatment Outcome | 2004 |
Gut hormones as peripheral anti obesity targets.
Topics: Animals; Anti-Obesity Agents; Appetite Regulation; Drug Design; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Mice; Obesity; Oxyntomodulin; Pancreatic Polypeptide; Peptide Fragments; Peptide Hormones; Peptide YY; Protein Precursors; Rats; Receptors, G-Protein-Coupled | 2004 |
Modern, new pharmacotherapy for obesity. A gastrointestinal approach.
Topics: Amylases; Androgens; Anti-Obesity Agents; Citrates; Cyclobutanes; Dietary Fats; Fat Substitutes; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Glucosidases; Human Growth Hormone; Humans; Intestinal Absorption; Lactones; Lipase; Obesity; Orlistat; Peptide Fragments; Protein Precursors; Sucrose | 2004 |
Gastric inhibitory polypeptide and glucagon-like peptide-1 in the pathogenesis of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 2004 |
The incretin approach for diabetes treatment: modulation of islet hormone release by GLP-1 agonism.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Islets of Langerhans; Peptide Fragments; Protein Precursors | 2004 |
Incretin mimetics as emerging treatments for type 2 diabetes.
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Liraglutide; Peptide Fragments; Peptides; Protein Precursors; Venoms | 2005 |
Glucagon-like peptide-1: regulation of insulin secretion and therapeutic potential.
Topics: Adenosine Triphosphate; Animals; Calcium; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Insulin Secretion; Ion Channels; Islets of Langerhans; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 2004 |
Structurally modified analogues of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) as future antidiabetic agents.
Topics: Animals; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Peptide Fragments; Protein Precursors; Structure-Activity Relationship | 2004 |
Unique characteristics of the geriatric diabetic population and the role for therapeutic strategies that enhance glucagon-like peptide-1 activity.
Topics: Aged; Aging; Blood Glucose; Diabetes Mellitus, Type 2; Geriatrics; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors | 2005 |
Islet adaptation to insulin resistance: mechanisms and implications for intervention.
Topics: Adaptation, Physiological; Animals; Blood Glucose; Cholinergic Agonists; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Metformin; Peptide Fragments; Protein Precursors; Sulfonylurea Compounds | 2005 |
Novel pharmacologic agents for type 2 diabetes.
Topics: Amyloid; Antigens, Neoplasm; Biomarkers, Tumor; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Detemir; Insulin, Long-Acting; Islet Amyloid Polypeptide; Lectins, C-Type; Pancreatitis-Associated Proteins; Peptide Fragments; Polymers; Protein Precursors; Thiazolidinediones | 2005 |
Harnessing the therapeutic potential of glucagon-like peptide-1: a critical review.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protein Precursors | 2002 |
[Impaired glucose tolerance in dumping syndrome].
Topics: Acarbose; Diet Therapy; Dumping Syndrome; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemia; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 2005 |
Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter.
Topics: Diabetes Mellitus, Type 2; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Neurotransmitter Agents; Peptide Fragments; Proglucagon; Protein Precursors | 2005 |
The physiological role of GLP-1 in human: incretin, ileal brake or more?
Topics: Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Peptides; Protein Precursors | 2005 |
What do we know about the secretion and degradation of incretin hormones?
Topics: Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Peptide Fragments; Protein Precursors | 2005 |
GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Mice; Mice, Knockout; Pancreas; Peptide Fragments; Protein Precursors; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 2005 |
Glucagon-like peptide 1 and its derivatives in the treatment of diabetes.
Topics: Amino Acid Sequence; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 2005 |
Glycaemic effects of incretins in Type 1 diabetes mellitus: a concise review, with emphasis on studies in humans.
Topics: Blood Glucose; Diabetes Mellitus, Type 1; Food; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Peptide Fragments; Protein Precursors; Time Factors | 2005 |
Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents?
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Peptide Fragments; Protease Inhibitors; Protein Precursors | 2005 |
[Glucagon-like peptides--synthesis, biological actions and some clinical implications].
Topics: Animals; Blood Glucose; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Intestinal Diseases; Intestinal Mucosa; Islets of Langerhans; Peptide Fragments; Peptides; Pilot Projects; Protein Precursors; Short Bowel Syndrome; Signal Transduction | 2004 |
Weight effect of current and experimental drugs for diabetes mellitus: from promotion to alleviation of obesity.
Topics: Amyloid; Benzamides; Biguanides; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insulin; Islet Amyloid Polypeptide; Obesity; Peptide Fragments; Protein Precursors; Sulfonylurea Compounds; Thiazolidinediones; Weight Gain | 2003 |
The incretins: a link between nutrients and well-being.
Topics: Animals; Autonomic Nervous System; Blood Glucose; Dietary Fiber; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Insulin; Insulin Resistance; Insulin Secretion; Intestinal Mucosa; Inulin; Mice; Peptide Fragments; Protein Precursors; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 2005 |
Advancements in the anti-diabetes chemotherapeutics based on amino acids, peptides, and peptidomimetics.
Topics: Amino Acids; Diabetes Mellitus; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Molecular Mimicry; Peptide Fragments; Peptides; Protein Precursors | 2005 |
Changes in insulin resistance following bariatric surgery: role of caloric restriction and weight loss.
Topics: Biomarkers; Blood Glucose; Body Mass Index; Caloric Restriction; Diabetes Mellitus, Type 2; Energy Metabolism; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Male; Obesity, Morbid; Peptide Fragments; Peptide Hormones; Prognosis; Protein Precursors; Treatment Outcome; Weight Loss | 2005 |
[Treatment of diabetes mellitus. New developments and hopes].
Topics: Adiponectin; Animals; Diabetes Mellitus; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glycogen Phosphorylase; Humans; Hypoglycemic Agents; Imidazoles; Insulin; Intercellular Signaling Peptides and Proteins; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Venoms | 2005 |
Enhancing central nervous system endogenous GLP-1 receptor pathways for intervention in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Brain; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Nerve Degeneration; Peptide Fragments; Protein Precursors; Risk Factors; Signal Transduction | 2005 |
New sources of pancreatic beta-cells.
Topics: Cell Differentiation; Diabetes Mellitus; Embryo, Mammalian; Embryo, Nonmammalian; Epidermal Growth Factor; Exenatide; Gastrins; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Pancreas; Peptide Fragments; Peptides; Protein Precursors; Regeneration; Stem Cells; Venoms | 2005 |
Physiology and pathophysiology of glucagon-like peptide-1 (GLP-1): the role of GLP-1 in the pathogenesis of diabetes mellitus, obesity, and stress.
Topics: Animals; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Humans; Obesity; Pancreas; Peptide Fragments; Protein Precursors; Stress, Physiological | 2005 |
[Therapeutic potential of DPP-IV inhibitor for the treatment of Type 2 diabetes].
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Nitriles; Peptide Fragments; Protein Precursors; Pyrrolidines | 2005 |
Glucagon-like peptide-1 as a treatment option for type 2 diabetes and its role in restoring beta-cell mass.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Islets of Langerhans; Mice; Models, Biological; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Satiation | 2005 |
Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intra-Arterial; Insulin; Insulin Secretion; Intestine, Small; Peptide Fragments; Protein Precursors | 2005 |
Proglucagon-derived peptides: mechanisms of action and therapeutic potential.
Topics: Animals; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Disease; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Intestinal Diseases; Peptide Fragments; Peptides; Proglucagon; Protease Inhibitors; Protein Precursors; Receptors, Glucagon | 2005 |
Glucagon-like peptide-1-based therapies for the treatment of type 2 diabetes mellitus.
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin-Secreting Cells; Satiety Response | 2005 |
Applications of dipeptidyl peptidase IV inhibitors in diabetes mellitus.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Humans; Molecular Sequence Data; Peptide Fragments; Protease Inhibitors | 2006 |
[Gluco-incretin hormones in insulin secretion].
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Islets of Langerhans | 2005 |
Therapies for the treatment of type 2 diabetes mellitus based on incretin action.
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Protein Synthesis Inhibitors; Satiety Response | 2006 |
Investigational treatments for Type 2 diabetes mellitus: exenatide and liraglutide.
Topics: Animals; Blood Glucose; Body Weight; Cell Proliferation; Diabetes Mellitus, Type 2; Drugs, Investigational; Exenatide; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Liraglutide; Peptides; Randomized Controlled Trials as Topic; Venoms | 2006 |
Major contributions of comparative endocrinology to the development and exploitation of the incretin concept.
Topics: Amino Acid Sequence; Animals; Anura; Exenatide; Fishes; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Hypoglycemic Agents; Intestinal Mucosa; Molecular Sequence Data; Peptide Fragments; Peptides; Sequence Alignment; Venoms | 2006 |
Biologic actions and therapeutic potential of the proglucagon-derived peptides.
Topics: Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Intestinal Mucosa; Proglucagon | 2005 |
Mechanisms of action of glucagon-like peptide 1 in the pancreas.
Topics: Animals; Diabetes Mellitus, Type 2; Enteroendocrine Cells; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Pancreas; Peptides; Receptors, Glucagon; Second Messenger Systems; Venoms | 2007 |
Incretins: a new treatment option for type 2 diabetes?
Topics: Adenosine Deaminase; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycoproteins; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Receptors, Glucagon; Satiety Response | 2007 |
DPP-4 inhibitors.
Topics: Adamantane; Animals; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipid Metabolism; Metformin; Nitriles; Pioglitazone; Protease Inhibitors; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Substrate Specificity; Thiazolidinediones; Triazoles; Vildagliptin | 2007 |
Islet cell function: alpha and beta cells--partners towards normoglycaemia.
Topics: Animals; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Humans; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Postprandial Period | 2008 |
GLP-1: physiological effects and potential therapeutic applications.
Topics: Animals; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Islets of Langerhans; Receptors, Glucagon; Satiety Response; Weight Loss | 2008 |
Exenatide: its position in the treatment of type 2 diabetes.
Topics: Clinical Trials as Topic; Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Peptides; Venoms | 2008 |
The incretins: from the concept to their use in the treatment of type 2 diabetes. Part A: incretins: concept and physiological functions.
Topics: Adipose Tissue; Body Weight; Diabetes Mellitus, Type 2; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Incretins; Insulin; Insulin Secretion; Overweight; Receptors, Glucagon | 2008 |
Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes.
Topics: Chemistry, Pharmaceutical; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glutaminase; Humans; Hypoglycemic Agents; Insulin; Intracellular Signaling Peptides and Proteins | 2009 |
Current and emerging therapies: an overview of incretin-based therapy in the management of type 2 diabetes.
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Progression; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Insulin Resistance; Middle Aged; Nurse Practitioners; Patient Selection; Primary Health Care | 2008 |
Glucagon and glucagon-like peptides 1 and 2.
Topics: Animals; Brain Stem; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Models, Biological; Neurons; Peptide Fragments; Peptides; Proprotein Convertase 1; Proprotein Convertase 2; Protein Processing, Post-Translational | 2010 |
The evolving place of incretin-based therapies in type 2 diabetes.
Topics: Adolescent; Adult; Animals; Child; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion | 2010 |
The perspectives of adjunctive drugs usage in the treatment of glucose metabolism disturbances in adolescent patients.
Topics: Adipose Tissue; Adolescent; Adult; Amyloid; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Islet Amyloid Polypeptide; Male; Receptors, Cannabinoid | 2009 |
Incretin physiology and its role in type 2 diabetes mellitus.
Topics: Adamantane; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Insulin; Liraglutide; Peptides; Pyrazines; Sitagliptin Phosphate; Triazoles; Venoms | 2010 |
Incretin-based therapies in the management of type 2 diabetes: rationale and reality in a managed care setting.
Topics: Adamantane; Algorithms; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Evidence-Based Medicine; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Secretion; Liraglutide; Managed Care Programs; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms | 2010 |
Liraglutide: the therapeutic promise from animal models.
Topics: Animals; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Liraglutide; Mice; Mice, Obese; Peptides; Rats; Rats, Zucker; Receptors, Glucagon; Swine; Swine, Miniature; Venoms | 2010 |
New physiological effects of the incretin hormones GLP-1 and GIP.
Topics: Adult; Appetite; Eating; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Islet Amyloid Polypeptide; Male; Postprandial Period | 2011 |
Is the GLP-1 system a viable therapeutic target for weight reduction?
Topics: Animals; Body Weight; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Weight Loss | 2011 |
GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities.
Topics: Animals; Diabetes Mellitus; Eating; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Islet Amyloid Polypeptide; Metabolic Diseases; Obesity; Receptors, Glucagon | 2012 |
Type 2 diabetes across generations: from pathophysiology to prevention and management.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diabetes, Gestational; Diabetic Retinopathy; Epigenesis, Genetic; Female; Fetal Development; Genetic Predisposition to Disease; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Incretins; Insulin Resistance; Insulin-Secreting Cells; Life Style; Liver; Muscle, Skeletal; Myocardium; Obesity; Prediabetic State; Pregnancy | 2011 |
Growth factor signalling in the regulation of α-cell fate.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Mice; Mice, Knockout; Signal Transduction | 2011 |
Regulation of glucagon secretion by incretins.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Incretins; Rats; Receptors, Glucagon | 2011 |
The role of dysregulated glucagon secretion in type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Hyperglycemia; Insulin-Secreting Cells; Liver; Mice | 2011 |
Pleiotropic effects of glucagon-like peptide-1 (GLP-1)-based therapies on vascular complications in diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Diabetic Nephropathies; Diabetic Neuropathies; Diabetic Retinopathy; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Receptors, Glucagon | 2011 |
[Glucagon and glucagon-like peptides the role in control glucose homeostasis. Part I].
Topics: Blood Glucose; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Humans; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans | 2011 |
Insulin sensitivity and secretion modifications after bariatric surgery.
Topics: Animals; Bariatric Surgery; Body Mass Index; Diabetes Mellitus, Type 2; Gastric Mucosa; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Incretins; Insulin Resistance; Insulin-Secreting Cells; Intestinal Mucosa; Obesity, Morbid | 2012 |
Unique roles of glucagon and glucagon-like peptides: Parallels in understanding the functions of adipokinetic hormones in stress responses in insects.
Topics: Animals; Brain; Cell Membrane; Cyclic AMP; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Insect Hormones; Insecta; Neurons; Oligopeptides; Oxidative Stress; Pyrrolidonecarboxylic Acid; Reactive Oxygen Species | 2013 |
The combination of insulin and GLP-1 analogues in the treatment of type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Treatment Outcome | 2012 |
Alpha cells come of age.
Topics: Animals; Cell Dedifferentiation; Cell Lineage; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Enteroendocrine Cells; Epithelial-Mesenchymal Transition; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Homeodomain Proteins; Humans; Hyperplasia; Insulin-Secreting Cells; Islets of Langerhans; Mice; Paired Box Transcription Factors; Proprotein Convertase 1; Signal Transduction; Transcription Factors | 2013 |
Structural aspects of gut peptides with therapeutic potential for type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Pituitary Adenylate Cyclase-Activating Polypeptide; Vasoactive Intestinal Peptide | 2013 |
Dysglycaemia in the critically ill - significance and management.
Topics: Analysis of Variance; Biomarkers; Blood Glucose; Critical Illness; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Risk Factors | 2013 |
Type 2 diabetes and the evolving paradigm in glucose regulation.
Topics: Adipocytes; Appetite; Brain; Diabetes Mellitus, Type 2; Fasting; Fatty Acids, Nonesterified; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Humans; Insulin Resistance; Insulin-Secreting Cells; Kidney; Liver; Muscle, Skeletal; Obesity; Sodium-Glucose Transport Proteins | 2013 |
Emerging combinatorial hormone therapies for the treatment of obesity and T2DM.
Topics: Animals; Blood Glucose; Body Weight; Central Nervous System; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Leptin; Obesity | 2013 |
[Effects of GLP-1 (glucagon-like peptide 1) on liver].
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Hepatocytes; Humans; Hypoglycemic Agents; Incretins; Insulin; Lipid Metabolism; Liver Diseases; Non-alcoholic Fatty Liver Disease; Oxidative Stress | 2013 |
[The cutting-edge of medicine; glucagon renaissance].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin-Secreting Cells | 2013 |
Pronounced reduction of postprandial glucagon by lixisenatide: a meta-analysis of randomized clinical trials.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Peptides; Postprandial Period; Randomized Controlled Trials as Topic | 2014 |
Can GLP-1 preparations be used in children and adolescents with diabetes mellitus?
Topics: Adolescent; Adult; Child; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Liraglutide; Male; Pediatric Obesity; Randomized Controlled Trials as Topic; Receptors, Glucagon | 2014 |
[GLP-1 analogues in treatment of type 1 diabetes mellitus].
Topics: Blood Glucose; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Evidence-Based Medicine; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Treatment Outcome | 2014 |
Physiological mechanisms of action of incretin and insulin in regulating skeletal muscle metabolism.
Topics: Blood Flow Velocity; Blood Glucose; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Humans; Hyperglycemia; Hypoglycemic Agents; Incretins; Insulin; Insulin Resistance; Microcirculation; Muscle, Skeletal | 2014 |
Therapeutic potential of coagonists of glucagon and GLP-1.
Topics: Animals; Cardiovascular Diseases; Glucagon; Glucagon-Like Peptide 1; Humans; Oxyntomodulin | 2014 |
Glucagon and type 2 diabetes: the return of the alpha cell.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans | 2014 |
How to fight obesity with antidiabetic drugs: targeting gut or kidney?
Topics: Anti-Obesity Agents; Bariatric Surgery; Biological Transport; Clinical Trials as Topic; Comorbidity; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Exenatide; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycosuria; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Kidney Tubules, Proximal; Microvilli; Multicenter Studies as Topic; Obesity; Peptides; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Venoms; Weight Loss | 2015 |
Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Energy Metabolism; Enteroendocrine Cells; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Homeostasis; Humans; Signal Transduction | 2015 |
Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass.
Topics: Anastomosis, Roux-en-Y; Blood Glucose; Body Mass Index; Denmark; Female; Follow-Up Studies; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Insulin-Secreting Cells; Male; Obesity, Morbid; Quality of Life; Treatment Outcome; Weight Loss | 2015 |
Gastrointestinal actions of glucagon-like peptide-1-based therapies: glycaemic control beyond the pancreas.
Topics: Diabetes Mellitus, Type 2; Fasting; Gastric Emptying; Gastrointestinal Agents; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Intestine, Small; Liver; Postprandial Period | 2016 |
Treatment potential of the GLP-1 receptor agonists in type 2 diabetes mellitus: a review.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion | 2016 |
Liraglutide in Type 2 Diabetes Mellitus: Clinical Pharmacokinetics and Pharmacodynamics.
Topics: Area Under Curve; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drug Interactions; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Lipids; Liraglutide; Liver Failure; Renal Insufficiency; Sex Factors | 2016 |
Do glucagonomas always produce glucagon?
Topics: Animals; Gastrointestinal Diseases; Gene Expression Regulation; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucagonoma; Humans; Hypoglycemia; Islets of Langerhans; Oxyntomodulin; Pancreas; Pancreatic Neoplasms; Peptide Fragments; Peptides; Phenotype; Proglucagon; Protein Domains | 2016 |
Glucose-dependent insulinotropic polypeptide: effects on insulin and glucagon secretion in humans.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Hypoglycemia; Insulin; Insulin Secretion; Male; Randomized Controlled Trials as Topic | 2016 |
Glucagon-related peptides and the regulation of food intake in chickens.
Topics: Animals; Brain; Chickens; Eating; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucose; Homeostasis; Intestinal Mucosa; Neurotransmitter Agents; Organ Specificity; Oxyntomodulin; Pancreas | 2016 |
Contribution of the distal small intestine to metabolic improvement after bariatric/metabolic surgery: Lessons from ileal transposition surgery.
Topics: Animals; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Eating; Endotoxemia; Enteroendocrine Cells; Gastric Bypass; Gastrointestinal Microbiome; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Ileum; Insulin; Insulin Resistance; Insulin Secretion; Rats | 2016 |
Pharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon.
Topics: Animals; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Male | 2016 |
The biology of glucagon and the consequences of hyperglucagonemia.
Topics: Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagonoma; Humans; Liver; Neoplasms; Non-alcoholic Fatty Liver Disease; Oxyntomodulin; Pancreas; Receptors, Glucagon | 2016 |
Physiological and pathophysiological aspects of incretin hormones and glucagon.
Topics: Animals; Appetite; Diabetes Mellitus, Type 2; Enteroendocrine Cells; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Oxyntomodulin; Peptide Fragments | 2017 |
Glucose kinetics: an update and novel insights into its regulation by glucagon and GLP-1.
Topics: Animals; Diabetes Mellitus, Type 2; Fasting; Gastric Emptying; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Gluconeogenesis; Glucose; Homeostasis; Humans; Hyperglycemia; Kinetics; Liver; Receptors, Glucagon; Satiation | 2017 |
The role of incretin hormones and glucagon in patients with liver disease.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Intolerance; Humans; Incretins; Insulin; Liver; Mice; Non-alcoholic Fatty Liver Disease | 2017 |
Glucagon and glucagon-like peptide-1 as novel anti-inflammatory and immunomodulatory compounds.
Topics: Animals; Anti-Inflammatory Agents; Glucagon; Glucagon-Like Peptide 1; Humans; Immunologic Factors; Inflammation | 2017 |
Genetic determinants of circulating GIP and GLP-1 concentrations.
Topics: ABO Blood-Group System; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enteroendocrine Cells; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Gastrointestinal Tract; Genetic Variation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-2 Receptor; Glucose; Glucose Tolerance Test; Homeodomain Proteins; Humans; Incretins; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Middle Aged; Prospective Studies; Receptors, Gastrointestinal Hormone; RNA, Messenger; Sodium-Glucose Transporter 1 | 2017 |
Optimization of peptide-based polyagonists for treatment of diabetes and obesity.
Topics: Amino Acid Sequence; Animals; Diabetes Mellitus, Type 2; Drug Discovery; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Obesity; Peptides | 2018 |
Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Peptides; Proteolysis | 2018 |
Cholecystokinin (CCK) and related adjunct peptide therapies for the treatment of obesity and type 2 diabetes.
Topics: Cholecystokinin; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Obesity; Peptides; Receptor, Cholecystokinin B | 2018 |
Glucagon-like peptide-1 receptor mediated control of cardiac energy metabolism.
Topics: Animals; Cardiovascular System; Diabetes Mellitus, Type 2; Energy Metabolism; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Myocardium; Oxidation-Reduction | 2018 |
The pleiotropic cardiovascular effects of dipeptidyl peptidase-4 inhibitors.
Topics: Cardiovascular Diseases; Cardiovascular System; Chemokine CXCL12; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Insulin; Natriuretic Peptide, Brain; Neuropeptide Y; Practice Guidelines as Topic; Proteolysis; Receptors, CXCR4 | 2018 |
[Technological Innovations in Diabetes Therapy].
Topics: Administration, Oral; Blood Glucose Self-Monitoring; Clinical Trials, Phase III as Topic; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Infusion Systems; Inventions; Pancreas, Artificial | 2018 |
Peptide-based multi-agonists: a new paradigm in metabolic pharmacology.
Topics: Animals; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Obesity; Peptides | 2018 |
Bidirectional Relationship between Gastric Emptying and Plasma Glucose Control in Normoglycemic Individuals and Diabetic Patients.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Postprandial Period | 2018 |
Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities.
Topics: Animals; Clinical Trials as Topic; Drug Therapy, Combination; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Metabolic Diseases; Molecular Targeted Therapy; Precision Medicine; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 2019 |
Glucagon, GLP-1 and Thermogenesis.
Topics: Adipose Tissue, Brown; Animals; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Humans; Molecular Targeted Therapy; Obesity; Thermogenesis | 2019 |
The Effects of Dual GLP-1/GIP Receptor Agonism on Glucagon Secretion-A Review.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Receptors, Gastrointestinal Hormone | 2019 |
The Role of α-Cells in Islet Function and Glucose Homeostasis in Health and Type 2 Diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Glucose; Humans; Hypoglycemia; Insulin | 2020 |
Glucagon and Glucagon-like Peptide-1 Receptors: Promising Therapeutic Targets for an Effective Management of Diabetes Mellitus.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Receptors, Glucagon | 2020 |
Combination gut hormones: prospects and questions for the future of obesity and diabetes therapy.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Gastrointestinal Microbiome; Glucagon; Glucagon-Like Peptide 1; Humans; Obesity; Peptide YY | 2020 |
A Review of Recent Findings on Meal Sequence: An Attractive Dietary Approach to Prevention and Management of Type 2 Diabetes.
Topics: Diabetes Mellitus, Type 2; Diet, Reducing; Dietary Carbohydrates; Dietary Fats; Dietary Fiber; Dietary Proteins; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Intestinal Mucosa; Meals; Nutritional Physiological Phenomena; Obesity | 2020 |
Paracrine regulation of insulin secretion.
Topics: Acetylcholine; Autocrine Communication; Corticotropin-Releasing Hormone; gamma-Aminobutyric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Insulin Secretion; Insulin-Secreting Cells; Paracrine Communication; Serotonin; Somatostatin; Somatostatin-Secreting Cells; Urocortins | 2020 |
Alpha cell regulation of beta cell function.
Topics: Acetylcholine; Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Humans; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Paracrine Communication | 2020 |
Glucose effectiveness: Lessons from studies on insulin-independent glucose clearance in mice.
Topics: Administration, Intravenous; Adult; Aged; Animals; Biological Transport; Diabetes Mellitus, Type 2; Disease Models, Animal; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Humans; Incretins; Insulin; Insulin Resistance; Insulin Secretion; Male; Mice; Middle Aged | 2021 |
Evidence for the existence and potential roles of intra-islet glucagon-like peptide-1.
Topics: Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Humans; Islets of Langerhans | 2021 |
Multi-organ Coordination of Lipoprotein Secretion by Hormones, Nutrients and Neural Networks.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Humans; Lipoproteins; Neural Networks, Computer; Nutrients | 2021 |
Proglucagon-Derived Peptides as Therapeutics.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Proglucagon | 2021 |
The Insulin Response to Oral Glucose in GIP and GLP-1 Receptor Knockout Mice: Review of the Literature and Stepwise Glucose Dose Response Studies in Female Mice.
Topics: Administration, Oral; Animals; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice, Inbred C57BL; Mice, Knockout; Receptors, Gastrointestinal Hormone | 2021 |
Peptidomics: A Review of Clinical Applications and Methodologies.
Topics: Glucagon; Glucagon-Like Peptide 1; Humans; Mass Spectrometry; Peptides; Proteomics | 2021 |
Altered islet prohormone processing: a cause or consequence of diabetes?
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Proglucagon; Proinsulin; Protein Precursors | 2022 |
Preproglucagon Products and Their Respective Roles Regulating Insulin Secretion.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Homeostasis; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Pancreas; Proglucagon | 2021 |
Potential for Gut Peptide-Based Therapy in Postprandial Hypotension.
Topics: Acarbose; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Gastrointestinal Agents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypotension; Insulin; Peptides; Postprandial Period; Somatostatin; Splanchnic Circulation | 2021 |
The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror.
Topics: Animals; Autocrine Communication; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Paracrine Communication | 2021 |
Peptides in the regulation of glucagon secretion.
Topics: Animals; Blood Glucose; Calcitonin; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Insulin; Islet Amyloid Polypeptide; Neurotensin; Oxyntomodulin; Oxytocin; Pancreas; Pancreatic Polypeptide; Somatostatin; Urocortins; Vasopressins | 2022 |
The current significance and prospects for the use of dual receptor agonism GLP-1/Glucagon.
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Incretins; Obesity | 2022 |
Glucagon-like peptide-1: Are its roles as endogenous hormone and therapeutic wizard congruent?
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans | 2022 |
Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis.
Topics: Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Homeostasis; Humans; Insulin; Insulin-Secreting Cells; Islets of Langerhans | 2022 |
Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone Peptide-Derived G Protein Coupled Receptor Agonists.
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Incretins; Peptides; Proglucagon | 2022 |
The Molecular Determinants of Glucagon-like Peptide Secretion by the Intestinal L cell.
Topics: Diabetes Mellitus, Type 2; Enteroendocrine Cells; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Peptide Fragments; Peptides; Secretagogues | 2022 |
Glucagon-like peptide-1 secretion in people with versus without type 2 diabetes: a systematic review and meta-analysis of cross-sectional studies.
Topics: Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fasting; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin | 2023 |
Four sidenotes about glucagon peptides.
Topics: Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Incretins; Peptides | 2023 |
Glucagon, from past to present: a century of intensive research and controversies.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemia; Receptors, Glucagon | 2023 |
[Gastrointestinal hormones: their increasing pharmacotherapeutic relevance in metabolic diseases].
Topics: Diabetes Mellitus, Type 2; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins | 2023 |
Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Obesity; Oxyntomodulin | 2023 |
The molecular pharmacology of glucagon agonists in diabetes and obesity.
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Mice; Obesity; Receptors, Glucagon | 2023 |
[Genetic aspects of type 1 glucagon peptide agonists clinical efficacy: A review].
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Metabolic Syndrome; Peptides; Venoms | 2023 |
Gut hormone-based pharmacology: novel formulations and future possibilities for metabolic disease therapy.
Topics: Body Weight; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Obesity | 2023 |
Gut hormone co-agonists for the treatment of obesity: from bench to bedside.
Topics: Diabetes Mellitus, Type 2; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Obesity; United States | 2023 |
Postprandial plasma GLP-1 levels are elevated in individuals with postprandial hypoglycaemia following Roux-en-Y gastric bypass - a systematic review.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemia; Insulin | 2023 |
Whey Protein Premeal Lowers Postprandial Glucose Concentrations in Adults Compared with Water-The Effect of Timing, Dose, and Metabolic Status: a Systematic Review and Meta-analysis.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Postprandial Period; Water; Whey Proteins | 2023 |
The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Incretins | 2023 |
328 trial(s) available for glucagon and glucagon-like peptide 1
| Article | Year |
|---|---|
Lack of effect of synthetic human gastric inhibitory polypeptide and glucagon-like peptide 1 [7-36 amide] infused at near-physiological concentrations on pentagastrin-stimulated gastric acid secretion in normal human subjects.
Topics: Adult; Blood Glucose; Gastric Acid; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hormones; Humans; Infusions, Intravenous; Male; Pentagastrin; Peptide Fragments; Stimulation, Chemical | 1992 |
Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Eating; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Kinetics; Male; Middle Aged; Peptide Fragments; Peptides; Reference Values; Time Factors | 1992 |
Pharmacokinetic, insulinotropic, and glucagonostatic properties of GLP-1 [7-36 amide] after subcutaneous injection in healthy volunteers. Dose-response-relationships.
Topics: Adult; Analysis of Variance; Blood Glucose; Body Mass Index; C-Peptide; Dose-Response Relationship, Drug; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Injections, Subcutaneous; Insulin; Kinetics; Male; Peptide Fragments; Random Allocation; Reference Values; Time Factors | 1995 |
Physiological augmentation of amino acid-induced insulin secretion by GIP and GLP-I but not by CCK-8.
Topics: Adult; Amino Acids; Dietary Proteins; Eating; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Male; Pancreas; Peptide Fragments; Peptides; Sincalide | 1995 |
Glucagon-like peptide-1 7-36 amide and peptide YY from the L-cell of the ileal mucosa are potent inhibitors of vagally induced gastric acid secretion in man.
Topics: Adult; Animals; Depression, Chemical; Female; Gastric Acid; Gastrins; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Ileum; Intestinal Mucosa; L Cells; Male; Mice; Middle Aged; Peptide Fragments; Peptide YY; Peptides; Somatostatin; Vagus Nerve | 1994 |
Subcutaneous injection of the incretin hormone glucagon-like peptide 1 abolishes postprandial glycemia in NIDDM.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Injections, Subcutaneous; Insulin; Male; Middle Aged; Peptide Fragments; Protein Precursors; Radioimmunoassay; Time Factors | 1994 |
Resistant starch: the effect on postprandial glycemia, hormonal response, and satiety.
Topics: Adult; Blood Glucose; Dietary Carbohydrates; Epinephrine; Food; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycerol; Hormones; Humans; Insulin; Lactates; Lactic Acid; Male; Norepinephrine; Peptide Fragments; Protein Precursors; Satiation; Starch; Triglycerides | 1994 |
Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Infusions, Intravenous; Kinetics; Male; Middle Aged; Peptide Fragments; Time Factors | 1993 |
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Glycated Hemoglobin; Humans; Insulin; Insulin Secretion; Kinetics; Male; Middle Aged; Peptide Fragments; Protein Precursors; Reference Values; Time Factors | 1993 |
Additive insulinotropic effects of exogenous synthetic human gastric inhibitory polypeptide and glucagon-like peptide-1-(7-36) amide infused at near-physiological insulinotropic hormone and glucose concentrations.
Topics: Administration, Oral; Adult; Blood Glucose; Drug Combinations; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Infusions, Intravenous; Insulin; Male; Osmolar Concentration; Pancreas; Peptide Fragments | 1993 |
Voglibose (AO-128) is an efficient alpha-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserve.
Topics: Adolescent; Adult; Blood Glucose; C-Peptide; Cyclohexanols; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Humans; Insulin; Male; Peptide Fragments; Protein Precursors | 1995 |
Gastric emptying, glucose responses, and insulin secretion after a liquid test meal: effects of exogenous glucagon-like peptide-1 (GLP-1)-(7-36) amide in type 2 (noninsulin-dependent) diabetic patients.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Peptide Fragments; Protein Precursors | 1996 |
Glucagonostatic actions and reduction of fasting hyperglycemia by exogenous glucagon-like peptide I(7-36) amide in type I diabetic patients.
Topics: Adult; Analysis of Variance; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Male; Peptide Fragments; Protein Precursors; Time Factors | 1996 |
No effect of beta-adrenergic blockade on hypoglycaemic effect of glucagon-like peptide-1 (GLP-1) in normal subjects.
Topics: Adrenergic beta-Antagonists; Adult; Analysis of Variance; Drug Interactions; Epinephrine; Fasting; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemia; Infusions, Intravenous; Insulin; Male; Norepinephrine; Peptide Fragments; Propranolol; Protein Precursors; Reference Values | 1996 |
Potential therapeutic levels of glucagon-like peptide I achieved in humans by a buccal tablet.
Topics: Absorption; Adult; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Half-Life; Humans; Insulin; Middle Aged; Peptide Fragments; Radioimmunoassay; Tablets | 1996 |
Glucagon-like peptide I enhances the insulinotropic effect of glibenclamide in NIDDM patients and in the perfused rat pancreas.
Topics: Analysis of Variance; Animals; Diabetes Mellitus, Type 2; Drug Synergism; Drug Therapy, Combination; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glyburide; Humans; In Vitro Techniques; Infusions, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Middle Aged; Peptide Fragments; Perfusion; Protein Precursors; Rats; Rats, Sprague-Dawley; Treatment Failure | 1996 |
GLP-1 does not not acutely affect insulin sensitivity in healthy man.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Analysis of Variance; Blood Glucose; C-Peptide; Calorimetry, Indirect; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Humans; Hydroxybutyrates; Infusions, Intravenous; Insulin; Insulin Secretion; Lactates; Male; Neurotransmitter Agents; Peptide Fragments; Reference Values; Somatostatin; Time Factors | 1996 |
The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients.
Topics: Blood Glucose; C-Peptide; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperlipoproteinemias; Hypoglycemic Agents; Insulin; Lipoproteins, VLDL; Male; Middle Aged; Peptide Fragments; Protein Precursors; Time Factors; Triglycerides | 1996 |
Postprandial hormone and metabolic responses in simulated shift work.
Topics: Adult; Blood Glucose; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Islets of Langerhans; Lipids; Male; Peptide Fragments; Postprandial Period; Protein Precursors; Triglycerides; Work Schedule Tolerance | 1996 |
Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Cohort Studies; Diabetes Mellitus, Type 2; Fasting; Female; Gastric Emptying; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Injections, Subcutaneous; Insulin; Male; Middle Aged; Peptide Fragments; Peptides | 1996 |
Effects of glucagon-like peptide 1 (7-36 amide) on whole-body protein metabolism in healthy man.
Topics: Adult; Blood Glucose; C-Peptide; Calorimetry, Indirect; Energy Metabolism; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Glycerol; Humans; Insulin; Leucine; Male; Pancreas; Peptide Fragments; Peptides; Proteins | 1997 |
Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM.
Topics: Adult; Aged; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Infusions, Intravenous; Islets of Langerhans; Male; Middle Aged; Peptide Fragments; Prospective Studies; Protein Precursors | 1997 |
Subcutaneous glucagon-like peptide I combined with insulin normalizes postcibal glycemic excursions in IDDM.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Male; Middle Aged; Pancreatic Polypeptide; Peptide Fragments; Time Factors | 1997 |
Acute incretin response to oral glucose is associated with stimulation of gastric inhibitory polypeptide, not glucagon-like peptide in young subjects.
Topics: Administration, Oral; Adolescent; Adult; C-Peptide; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Clamp Technique; Humans; Hyperglycemia; Peptide Fragments; Peptides; Secretory Rate; Stimulation, Chemical | 1997 |
Glucagon-like peptide-1 7-36 amide and peptide YY have additive inhibitory effect on gastric acid secretion in man.
Topics: Adult; Drug Interactions; Female; Gastric Acid; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Infusions, Intravenous; Male; Middle Aged; Neurotransmitter Agents; Pentagastrin; Peptide Fragments; Peptide YY; Peptides | 1997 |
Glucagon-like peptide-1 (GLP-1): a trial of treatment in non-insulin-dependent diabetes mellitus.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Injections, Subcutaneous; Insulin; Male; Middle Aged; Peptides | 1997 |
Glucagon-like peptide-1 reduces hepatic glucose production indirectly through insulin and glucagon in humans.
Topics: Blood Glucose; Depression, Chemical; Female; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucose; Hormone Antagonists; Humans; Insulin; Insulin Antagonists; Kinetics; Liver; Middle Aged; Peptides; Somatostatin | 1997 |
Glucagon-like peptide 1 and its potential in the treatment of non-insulin-dependent diabetes mellitus.
Topics: Acarbose; Aged; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Metformin; Middle Aged; Peptide Fragments; Protein Precursors; Regression Analysis; Sulfonylurea Compounds; Trisaccharides | 1997 |
Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans.
Topics: Adult; Blood Glucose; C-Peptide; Eating; Fasting; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Peptide Fragments; Peptides; Postprandial Period; Protein Precursors; Reference Values; Time Factors | 1997 |
A liquid mixed meal or exogenous glucagon-like peptide 1 (GLP-1) do not alter plasma leptin concentrations in healthy volunteers.
Topics: Adult; Blood Glucose; Food, Formulated; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Insulin; Leptin; Peptide Fragments; Postprandial Period; Protein Precursors; Proteins; Time Factors | 1997 |
GLP-1 tablet in type 2 diabetes in fasting and postprandial conditions.
Topics: Absorption; Administration, Buccal; Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Half-Life; Humans; Insulin; Male; Middle Aged; Peptide Fragments; Postprandial Period; Protein Precursors; Tablets | 1997 |
Glucagon-like peptide 1 increases mass but not frequency or orderliness of pulsatile insulin secretion.
Topics: Adult; Blood Glucose; C-Peptide; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Pulsatile Flow; Time Factors | 1998 |
The ethanol augmentation of glucose-induced insulin secretion is abolished by calcium antagonism with nifedipine: no evidence for a role of glucagon-like peptide-1 (GLP-1).
Topics: Adult; C-Peptide; Calcium Channel Blockers; Ethanol; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Male; Nifedipine; Peptide Fragments; Protein Precursors | 1998 |
No correlation between insulin and islet amyloid polypeptide after stimulation with glucagon-like peptide-1 in type 2 diabetes.
Topics: Adult; Amyloid; Diabetes Mellitus, Type 2; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Islet Amyloid Polypeptide; Male; Middle Aged; Peptide Fragments; Protein Precursors | 1997 |
Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.
Topics: Adult; Appetite; Appetite Depressants; Appetite Regulation; Blood Glucose; Cross-Over Studies; Energy Intake; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Pain Measurement; Peptide Fragments; Protein Precursors; Satiation | 1998 |
Mechanisms of the antidiabetic action of subcutaneous glucagon-like peptide-1(7-36)amide in non-insulin dependent diabetes mellitus.
Topics: Aged; Blood Glucose; Breath Tests; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Injections, Subcutaneous; Insulin; Male; Middle Aged; Neurotransmitter Agents; Pancreatic Polypeptide; Peptide Fragments; Postprandial Period; Regression Analysis | 1998 |
Inhibitory effects of hyperglycaemia on fed jejunal motility: potential role of hyperinsulinaemia.
Topics: Adult; Blood Glucose; Body Mass Index; C-Peptide; Drug Combinations; Gastrointestinal Motility; Gastrointestinal Transit; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Hyperglycemia; Hyperinsulinism; Insulin; Jejunum; Male; Pancreatic Polypeptide; Peptide Fragments; Perfusion; Phospholipids; Protein Precursors; Sorbitol | 1998 |
Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.
Topics: Adult; C-Peptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Male; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Time Factors | 1998 |
Overnight GLP-1 normalizes fasting but not daytime plasma glucose levels in NIDDM patients.
Topics: Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Drug Administration Schedule; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Peptide Fragments; Postprandial Period; Protein Precursors; Single-Blind Method; Time Factors; Treatment Outcome | 1998 |
Prolonged and enhanced secretion of glucagon-like peptide 1 (7-36 amide) after oral sucrose due to alpha-glucosidase inhibition (acarbose) in Type 2 diabetic patients.
Topics: Acarbose; Administration, Oral; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Peptide Fragments; Sucrose; Time Factors; Trisaccharides | 1998 |
Subcutaneous glucagon-like peptide-1 improves postprandial glycaemic control over a 3-week period in patients with early type 2 diabetes.
Topics: Adult; Analysis of Variance; Area Under Curve; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Male; Peptide Fragments; Postprandial Period; Protein Precursors | 1998 |
Glucagon-like peptide 1 increases the period of postprandial satiety and slows gastric emptying in obese men.
Topics: Adult; Blood Glucose; C-Peptide; Double-Blind Method; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Infusions, Intravenous; Insulin; Male; Obesity; Pain Measurement; Peptide Fragments; Postprandial Period; Protein Precursors; Radioimmunoassay; Satiation | 1998 |
Interaction of insulin, glucagon-like peptide 1, gastric inhibitory polypeptide, and appetite in response to intraduodenal carbohydrate.
Topics: Adult; Appetite; Blood Glucose; Diet; Energy Intake; Gastric Inhibitory Polypeptide; Gastrointestinal Agents; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Infusions, Parenteral; Insulin; Male; Octreotide; Peptide Fragments; Protein Precursors; Single-Blind Method | 1998 |
Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure.
Topics: Aged; Blood Glucose; C-Peptide; Calorimetry, Indirect; Cholesterol; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Peptide Fragments; Postprandial Period; Proinsulin; Protein Precursors; Sulfonylurea Compounds; Triglycerides | 1998 |
Normalization of fasting glycaemia by intravenous GLP-1 ([7-36 amide] or [7-37]) in type 2 diabetic patients.
Topics: Age of Onset; Aged; Blood Glucose; C-Peptide; Calorimetry, Indirect; Cholesterol; Diabetes Mellitus, Type 2; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Insulin Secretion; Male; Middle Aged; Peptide Fragments; Peptides; Triglycerides | 1998 |
Subcutaneous glucagon-like peptide-1 (7-36) amide is insulinotropic and can cause hypoglycaemia in fasted healthy subjects.
Topics: Adult; Blood Glucose; Blood Pressure; Cross-Over Studies; Double-Blind Method; Fasting; Female; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Male; Peptide Fragments; Pulse | 1998 |
Glucagon-like peptide-1: a potent regulator of food intake in humans.
Topics: Adult; Blood Glucose; Cholecystokinin; Dose-Response Relationship, Drug; Double-Blind Method; Eating; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Insulin; Leptin; Male; Peptide Fragments; Protein Precursors; Proteins | 1999 |
Energy intake and appetite are suppressed by glucagon-like peptide-1 (GLP-1) in obese men.
Topics: Adult; Appetite; Blood Glucose; Body Mass Index; C-Peptide; Cross-Over Studies; Double-Blind Method; Eating; Energy Intake; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Infusions, Intravenous; Insulin; Male; Obesity; Peptide Fragments; Peptide YY; Protein Precursors | 1999 |
Effects of age on concentrations of plasma cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility.
Topics: Adult; Aged; Aged, 80 and over; Aging; Appetite; Cholecystokinin; Duodenum; Fats; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Male; Peptide Fragments; Peptide YY; Protein Precursors | 1999 |
Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2.
Topics: Appetite; Blood Glucose; Brain Chemistry; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Eating; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Infusions, Intravenous; Insulin; Male; Middle Aged; Obesity; Peptide Fragments; Protein Precursors; Satiation | 1999 |
Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects.
Topics: Adult; Blood Glucose; Butter; Cholesterol, HDL; Diet; Dietary Fats; Fatty Acids; Fatty Acids, Monounsaturated; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Male; Neurotransmitter Agents; Olive Oil; Peptide Fragments; Peptides; Plant Oils; Postprandial Period; Triglycerides | 1999 |
Octreotide suppresses the incretin glucagon-like peptide (7-36) amide in patients with acromegaly or clinically nonfunctioning pituitary tumors and in healthy subjects.
Topics: Acromegaly; Adenoma; Adult; Antineoplastic Agents, Hormonal; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Hormones; Human Growth Hormone; Humans; Insulin; Male; Middle Aged; Octreotide; Peptide Fragments; Pituitary Neoplasms; Prospective Studies; Protein Precursors | 1999 |
Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients.
Topics: Adult; Aged; Appetite; Appetite Depressants; Blood Glucose; Blood Pressure; C-Peptide; Diabetes Mellitus, Type 2; Drug Delivery Systems; Energy Intake; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Infusion Pumps; Insulin; Lipids; Middle Aged; Peptide Fragments; Peptides; Pilot Projects; Postprandial Period; Protein Precursors | 1999 |
Inhibition of sham feeding-stimulated human gastric acid secretion by glucagon-like peptide-2.
Topics: Cholecystokinin; Gastric Acid; Gastrins; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Infusions, Intravenous; Peptide Fragments; Peptides; Protein Precursors; Secretin | 1999 |
Inhibition of human gastric lipase by intraduodenal fat involves glucagon-like peptide-1 and cholecystokinin.
Topics: Adult; Cholecystokinin; Duodenum; Fats; Female; Fish Oils; Gastric Acid; Gastrins; Glucagon; Glucagon-Like Peptide 1; Humans; Lipase; Male; Peptide Fragments; Protein Precursors; Reference Values; Secretin; Stomach | 1999 |
Effect of glucagon-like peptide 1(7-36)amide in insulin-treated patients with diabetes mellitus secondary to chronic pancreatitis.
Topics: Aged; Blood Glucose; C-Peptide; Chronic Disease; Diabetes Mellitus; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycated Hemoglobin; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Middle Aged; Pancreatitis; Peptide Fragments | 2000 |
Effects of intraduodenal glucose and fructose on antropyloric motility and appetite in healthy humans.
Topics: Adult; Appetite; Blood Glucose; Catheterization; Duodenum; Female; Fructose; Gastric Inhibitory Polypeptide; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Intubation, Gastrointestinal; Male; Peptide Fragments; Pressure; Protein Precursors; Pylorus; Reference Values; Single-Blind Method | 2000 |
Antidiabetogenic action of cholecystokinin-8 in type 2 diabetes.
Topics: Aged; Area Under Curve; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Pancreas; Peptide Fragments; Postprandial Period; Protein Precursors; Sincalide | 2000 |
The effect of glucagon-like peptide-1 on energy expenditure and substrate metabolism in humans.
Topics: Adult; Basal Metabolism; Body Mass Index; Cholecystokinin; Cross-Over Studies; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Energy Intake; Energy Metabolism; Fatty Acids, Nonesterified; Food; Glucagon; Glucagon-Like Peptide 1; Humans; Kinetics; Male; Oxidation-Reduction; Peptide Fragments; Placebos; Protein Precursors | 2000 |
A novel hyperglycaemic clamp for characterization of islet function in humans: assessment of three different secretagogues, maximal insulin response and reproducibility.
Topics: Adult; Arginine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Clamp Technique; Humans; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Reproducibility of Results | 2000 |
Influence of acarbose on post-prandial insulin requirements in patients with Type 1 diabetes.
Topics: Acarbose; Adult; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 1; Double-Blind Method; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Male; Peptide Fragments; Postprandial Period; Protein Precursors; Triglycerides | 2000 |
Short-term treatment with GLP-1 increases pulsatile insulin secretion in Type II diabetes with no effect on orderliness.
Topics: Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Middle Aged; Peptide Fragments; Periodicity; Protein Precursors | 2000 |
Effect of glucagon-like peptide 1(7-36) amide on glucose effectiveness and insulin action in people with type 2 diabetes.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Food; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Human Growth Hormone; Humans; Hydrocortisone; Insulin; Kinetics; Peptide Fragments; Somatostatin | 2000 |
No effect of glucagon-like peptide-1 on short-term satiety and energy intake in man.
Topics: Adult; Appetite Regulation; Cross-Over Studies; Drinking; Energy Intake; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Male; Peptide Fragments; Protein Precursors; Satiation; Single-Blind Method | 1999 |
Diet-induced change in fatty acid composition of plasma triacylglycerols is not associated with change in glucagon-like peptide 1 or insulin sensitivity in people with type 2 diabetes.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Fats, Unsaturated; Double-Blind Method; Fatty Acids; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Linoleic Acid; Oleic Acid; Peptide Fragments; Protein Precursors; Triglycerides | 2000 |
Effect of nutrient ingestion on glucagon-like peptide 1 (7-36 amide) secretion in human type 1 and type 2 diabetes.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Eating; Female; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Male; Middle Aged; Peptide Fragments; Radioimmunoassay | 2000 |
Circulating levels of incretin hormones and amylin in the fasting state and after oral glucose in GH-deficient patients before and after GH replacement: a placebo-controlled study.
Topics: Adult; Amyloid; Fasting; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Growth Hormone; Hormone Replacement Therapy; Human Growth Hormone; Humans; Islet Amyloid Polypeptide; Male; Peptide Fragments; Protein Precursors | 2000 |
Glucagon-like peptide 1 increases secretory burst mass of pulsatile insulin secretion in patients with type 2 diabetes and impaired glucose tolerance.
Topics: Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 2; Entropy; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Hormones; Humans; Injections, Intravenous; Insulin; Insulin Secretion; Male; Middle Aged; Osmolar Concentration; Peptide Fragments; Protein Precursors; Pulsatile Flow; Reference Values | 2001 |
Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects.
Topics: Adolescent; Adult; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Leptin; Male; Metformin; Middle Aged; Obesity; Peptide Fragments; Peptides | 2001 |
Additive glucose-lowering effects of glucagon-like peptide-1 and metformin in type 2 diabetes.
Topics: Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Therapy, Combination; Female; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycated Hemoglobin; Humans; Infusions, Parenteral; Insulin; Insulin Secretion; Kinetics; Male; Metformin; Middle Aged; Peptide Fragments; Placebos; Research Design | 2001 |
The effect of physiological levels of glucagon-like peptide-1 on appetite, gastric emptying, energy and substrate metabolism in obesity.
Topics: Adult; Appetite; Basal Metabolism; Body Mass Index; Energy Metabolism; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Kinetics; Male; Obesity; Oxidation-Reduction; Peptide Fragments; Protein Precursors | 2001 |
GLP-1-induced alterations in the glucose-stimulated insulin secretory dose-response curve.
Topics: Adult; Blood Glucose; C-Peptide; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; White People | 2001 |
Antidiabetogenic action of glucagon-like peptide-1 related to administration relative to meal intake in subjects with type 2 diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Administration Schedule; Eating; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Male; Middle Aged; Peptide Fragments; Protein Precursors; Time Factors | 2001 |
Glucagon-like peptide-1 infusion must be maintained for 24 h/day to obtain acceptable glycemia in type 2 diabetic patients who are poorly controlled on sulphonylurea treatment.
Topics: Adult; Aged; Area Under Curve; Blood Glucose; Circadian Rhythm; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Infusions, Intravenous; Inpatients; Insulin; Male; Middle Aged; Peptide Fragments; Placebos; Protein Precursors; Sulfonylurea Compounds; Time Factors | 2001 |
Inhibition of gastric emptying by acarbose is correlated with GLP-1 response and accompanied by CCK release.
Topics: Acarbose; Administration, Oral; Adult; Area Under Curve; Blood Glucose; Cholecystokinin; Diarrhea; Dietary Carbohydrates; Energy Intake; Enzyme Inhibitors; Flatulence; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Peptide Fragments; Peptide YY; Protein Precursors; Sucrose | 2001 |
Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men.
Topics: Adult; Biomarkers; Blood Glucose; Blood Pressure; Body Weight; Eating; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Peptide Fragments; Postprandial Period; Protein Precursors; Regression Analysis | 2001 |
Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes.
Topics: Administration, Oral; Aged; Analysis of Variance; Blood Glucose; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Patient Selection; Peptide Fragments; Peptides | 2001 |
Glucagon-like peptide-1 (7-37) augments insulin-mediated glucose uptake in elderly patients with diabetes.
Topics: Aged; Biological Transport, Active; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Clamp Technique; Humans; Insulin; Peptide Fragments; Peptides | 2001 |
Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes.
Topics: Aged; Blood Glucose; Cross-Over Studies; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Administration Schedule; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Insulin; Insulin Secretion; Liraglutide; Male; Middle Aged; Osmolar Concentration; Postprandial Period | 2002 |
Postprandial glucose, insulin, and incretin responses to grain products in healthy subjects.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Blood Glucose; Bread; Dietary Fiber; Fasting; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Male; Neurotransmitter Agents; Peptide Fragments; Postprandial Period; Secale; Triticum | 2002 |
Men at increased risk of coronary heart disease are not different from age- and weight-matched healthy controls in their postprandial triglyceride, nonesterified fatty acid, or incretin responses to sucrose.
Topics: Blood Glucose; Case-Control Studies; Coronary Disease; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Male; Peptide Fragments; Postprandial Period; Risk Factors; Sucrose; Triglycerides | 2002 |
Effects of glucagon-like peptide-1(7-36)amide on motility and sensation of the proximal stomach in humans.
Topics: Adult; Blood Glucose; Gastric Emptying; Gastric Fundus; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Male; Muscle Relaxation; Peptide Fragments; Pressure; Satiety Response | 2002 |
Effect of GLP-1 on gastric volume, emptying, maximum volume ingested, and postprandial symptoms in humans.
Topics: Adult; Blood Glucose; Dietary Sucrose; Double-Blind Method; Female; Food; Food, Formulated; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Pancreatic Polypeptide; Peptide Fragments; Placebos; Protein Precursors; Satiation; Stomach; Tomography, Emission-Computed, Single-Photon | 2002 |
Effects of glucagon-like peptide 1 on counterregulatory hormone responses, cognitive functions, and insulin secretion during hyperinsulinemic, stepped hypoglycemic clamp experiments in healthy volunteers.
Topics: Adult; Blood Glucose; Cognition; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Hormones; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Insulin Secretion; Male; Osmolar Concentration; Peptide Fragments; Protein Precursors; Reference Values | 2002 |
Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and beta-cell function in type 2 diabetes: a parallel-group study.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Islets of Langerhans; Male; Middle Aged; Peptide Fragments; Pilot Projects; Protein Precursors | 2002 |
Impaired beta-cell function, incretin effect, and glucagon suppression in patients with type 1 diabetes who have normal fasting glucose.
Topics: Arginine; Autoantibodies; Blood Glucose; Diabetes Mellitus, Type 1; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Reference Values | 2002 |
The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men.
Topics: Adolescent; Adult; Area Under Curve; Blood Glucose; Dose-Response Relationship, Drug; Double-Blind Method; Glucagon; Glucagon-Like Peptide 1; Humans; Liraglutide; Male; Middle Aged; Peptide Fragments; Placebos; Protein Precursors; Reference Values; Safety | 2002 |
Acute ingestion of a meal rich in n-3 polyunsaturated fatty acids results in rapid gastric emptying in humans.
Topics: Aldose-Ketose Isomerases; Body Mass Index; Breath Tests; Caprylates; Carbon Isotopes; Cholecystokinin; Dietary Fats, Unsaturated; Escherichia coli Proteins; Fatty Acids, Omega-3; Female; Food; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Lipids; Middle Aged; Peptide Fragments; Peptide YY; Protein Precursors | 2002 |
Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects.
Topics: Adolescent; Adult; Blood Glucose; Double-Blind Method; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Liraglutide; Male; Middle Aged | 2002 |
Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Obesity; Peptide Fragments; Protein Precursors | 2002 |
Plasma glucagon-like peptide-1 (GLP-1) responses to duodenal fat and glucose infusions in lean and obese men.
Topics: Adolescent; Adult; Dietary Fats; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Male; Obesity; Peptide Fragments; Protein Precursors; Thinness | 2002 |
Circulating levels of ghrelin and GLP-1 are inversely related during glucose ingestion.
Topics: Adult; Blood Glucose; Female; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Hormones; Human Growth Hormone; Humans; Insulin; Leptin; Peptide Fragments; Peptide Hormones; Protein Precursors | 2002 |
The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics.
Topics: 1-Deoxynojirimycin; Adult; Aged; Appetite; Diabetes Mellitus; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucosamine; Humans; Hypoglycemic Agents; Imino Pyranoses; Middle Aged; Obesity; Peptide Fragments; Postprandial Period; Protein Precursors | 2002 |
High-fat diet effects on gut motility, hormone, and appetite responses to duodenal lipid in healthy men.
Topics: Adult; Appetite; Cholecystokinin; Diet; Dietary Fats; Duodenum; Eating; Energy Metabolism; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Hormones; Humans; Hunger; Intubation, Gastrointestinal; Male; Muscle Tonus; Peptide Fragments; Protein Precursors; Pylorus | 2003 |
The effects of fiber enrichment of pasta and fat content on gastric emptying, GLP-1, glucose, and insulin responses to a meal.
Topics: Adult; Analysis of Variance; Area Under Curve; Blood Glucose; Cross-Over Studies; Dietary Fats; Dietary Fiber; Female; Food, Fortified; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Insulin; Male; Peptide Fragments; Protein Precursors; Reference Values; Single-Blind Method; Time Factors; Triticum | 2003 |
Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal hormone secretion and appetite.
Topics: Adult; Amino Acids; Analysis of Variance; Caseins; Cholecystokinin; Dietary Proteins; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Peptide Fragments; Postprandial Period; Protein Precursors; Satiation; Single-Blind Method | 2003 |
Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes.
Topics: Area Under Curve; Blood Glucose; Butter; Cholesterol, HDL; Chylomicrons; Coronary Artery Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fatty Acids; Fatty Acids, Monounsaturated; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Obesity; Olive Oil; Peptide Fragments; Plant Oils; Postprandial Period; Protein Precursors; Triglycerides | 2003 |
Differential effects of acute and extended infusions of glucagon-like peptide-1 on first- and second-phase insulin secretion in diabetic and nondiabetic humans.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Peptide Fragments; Protein Precursors | 2003 |
Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Humans; Hyperinsulinism; Insulin; Liver; Male; Neurotransmitter Agents; Peptide Fragments; Peptides | 2003 |
Colonic fermentation influences lower esophageal sphincter function in gastroesophageal reflux disease.
Topics: Administration, Oral; Adult; Breath Tests; Cholecystokinin; Colon; Cross-Over Studies; Diet; Esophagogastric Junction; Female; Fermentation; Gastroesophageal Reflux; Glucagon; Glucagon-Like Peptide 1; Humans; Hydrogen; Male; Middle Aged; Oligosaccharides; Patient Compliance; Peptide Fragments; Peptide YY; Postprandial Period; Protein Precursors | 2003 |
Effects of fat digestion on appetite, APD motility, and gut hormones in response to duodenal fat infusion in humans.
Topics: Adult; Appetite; Cholecystokinin; Cross-Over Studies; Dietary Fats; Double-Blind Method; Duodenum; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Humans; Lipase; Male; Peptide Fragments; Protein Precursors; Triglycerides | 2003 |
Glucose-dependent insulinotropic polypeptide and insulin-like immunoreactivity in saliva following sham-fed and swallowed meals.
Topics: Adult; alpha-Amylases; Analysis of Variance; Blood Glucose; Blood Proteins; Cross-Over Studies; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Male; Mastication; Peptide Fragments; Postprandial Period; Protein Precursors; Saliva; Salivary Proteins and Peptides; Spectrophotometry | 2003 |
Suppression of glucose production by GLP-1 independent of islet hormones: a novel extrapancreatic effect.
Topics: Adult; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Clamp Technique; Humans; Insulin; Islets of Langerhans; Male; Metabolic Clearance Rate; Middle Aged; Pancreatic Hormones; Peptide Fragments; Protein Precursors | 2003 |
Physiological mechanisms mediating aspartame-induced satiety.
Topics: Adult; Appetite; Aspartame; Aspartic Acid; Blood Glucose; Cholecystokinin; Cross-Over Studies; Diet; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Hormones; Humans; Insulin; Male; Peptide Fragments; Phenylalanine; Protein Precursors; Satiety Response; Sweetening Agents | 2003 |
Normalization of glucose concentrations and deceleration of gastric emptying after solid meals during intravenous glucagon-like peptide 1 in patients with type 2 diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fasting; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Injections, Intravenous; Male; Middle Aged; Osmolar Concentration; Peptide Fragments; Postprandial Period; Protein Precursors; Time Factors | 2003 |
Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative.
Topics: Adult; Blood Glucose; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Liraglutide; Male; Nonlinear Dynamics; Peptide Fragments; Protein Precursors | 2003 |
The GLP-1 derivative NN2211 restores beta-cell sensitivity to glucose in type 2 diabetic patients after a single dose.
Topics: Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Liraglutide; Male; Middle Aged; Peptide Fragments; Placebos; Protein Precursors; Reference Values | 2003 |
Effect of lipase inhibition on gastric emptying of, and the glycemic and incretin responses to, an oil/aqueous drink in type 2 diabetes mellitus.
Topics: Autonomic Nervous System; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Fats; Enzyme Inhibitors; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hemodynamics; Humans; Insulin; Lactones; Lipase; Male; Middle Aged; Orlistat; Peptide Fragments; Peptides | 2003 |
No hypoglycemia after subcutaneous administration of glucagon-like peptide-1 in lean type 2 diabetic patients and in patients with diabetes secondary to chronic pancreatitis.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Chronic Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemia; Injections, Subcutaneous; Insulin; Kinetics; Middle Aged; Pancreatitis; Peptide Fragments; Protein Precursors | 2003 |
Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes.
Topics: Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Drug Implants; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Injections, Subcutaneous; Insulin; Male; Peptide Fragments; Protein Precursors; Treatment Outcome | 2003 |
Characterization of GLP-1 effects on beta-cell function after meal ingestion in humans.
Topics: Aged; Blood Glucose; C-Peptide; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Postprandial Period; Protein Precursors | 2003 |
Absence of a memory effect for the insulinotropic action of glucagon-like peptide 1 (GLP-1) in healthy volunteers.
Topics: Adult; Analysis of Variance; Blood Glucose; C-Peptide; Fasting; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptides; Reference Values | 2003 |
Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine.
Topics: Adult; Area Under Curve; Blood Glucose; Caffeine; Chlorogenic Acid; Coffee; Cross-Over Studies; Diet; Female; Flavonoids; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Male; Peptide Fragments; Phenols; Polymers; Polyphenols; Postprandial Period; Protein Precursors | 2003 |
The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Chronic Disease; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Hyperglycemia; Insulin; Islets of Langerhans; Male; Middle Aged; Neurotransmitter Agents; Nuclear Proteins; Pancreatitis; Peptide Fragments; Phenotype; Protein Precursors; Transcription Factors | 2003 |
Structural differences between rye and wheat breads but not total fiber content may explain the lower postprandial insulin response to rye bread.
Topics: Blood Glucose; Bread; C-Peptide; Dietary Fiber; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hydrolysis; Insulin; Kinetics; Microscopy; Middle Aged; Peptide Fragments; Protein Precursors; Secale; Starch; Triticum | 2003 |
Recombinant glucagon-like peptide-1 (7-36 amide) lowers fasting serum glucose in a broad spectrum of patients with type 2 diabetes.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Insulin; Metformin; Peptide Fragments; Placebos; Recombinant Proteins; Sulfonylurea Compounds | 2003 |
Antihyperglycemic effects of stevioside in type 2 diabetic subjects.
Topics: Aged; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Diterpenes; Diterpenes, Kaurane; Diuresis; Fatty Acids, Nonesterified; Female; Food; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucosides; Glycated Hemoglobin; Glycosuria; Humans; Hypoglycemic Agents; Insulin; Kinetics; Male; Middle Aged; Peptide Fragments; Placebos; Protein Precursors; Triglycerides | 2004 |
Ethanol with a mixed meal decreases the incretin levels early postprandially and increases postprandial lipemia in type 2 diabetic patients.
Topics: Aged; Alcohol Drinking; Butter; Cholesterol; Cholesterol, HDL; Chylomicrons; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Dietary Fats; Energy Intake; Ethanol; Fatty Acids; Fatty Acids, Nonesterified; Food; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Lipids; Middle Aged; Peptide Fragments; Protein Precursors; Triglycerides | 2004 |
Race affects insulin and GLP-1 secretion and response to a long-acting somatostatin analogue in obese adults.
Topics: Adult; Anthropometry; Black or African American; Female; Gastrointestinal Agents; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Male; Obesity; Octreotide; Peptide Fragments; Prospective Studies; Protein Precursors; White People | 2004 |
Blood glucose control in healthy subject and patients receiving intravenous glucose infusion or total parenteral nutrition using glucagon-like peptide 1.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fatty Acids; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Hyperglycemia; Infusions, Intravenous; Insulin; Male; Middle Aged; Parenteral Nutrition, Total; Peptide Fragments; Placebos | 2004 |
Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Blood Glucose; Combined Modality Therapy; Diabetes Complications; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Male; Middle Aged; Myocardial Infarction; Peptide Fragments; Pilot Projects; Safety; Stroke Volume; Treatment Outcome; Ventricular Function, Left | 2004 |
Glucagon-like peptide 1 (GLP-1) secretion and plasma dipeptidyl peptidase IV (DPP-IV) activity in morbidly obese patients undergoing biliopancreatic diversion.
Topics: Adult; Biliopancreatic Diversion; Dipeptidyl Peptidase 4; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Obesity, Morbid; Peptide Fragments; Postoperative Period; Protein Precursors; Weight Loss | 2004 |
Prandial subcutaneous injections of glucagon-like peptide-1 cause weight loss in obese human subjects.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Eating; Feeding Behavior; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Infusions, Parenteral; Injections, Subcutaneous; Male; Middle Aged; Nausea; Obesity; Peptide Fragments; Protein Precursors; Recombinant Proteins; Satiation; Thirst; Weight Loss | 2004 |
Intravenous glucagon-like peptide 1 normalizes blood glucose after major surgery in patients with type 2 diabetes.
Topics: Adult; Aged; Analysis of Variance; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Hypoglycemic Agents; Infusions, Intravenous; Male; Middle Aged; Peptide Fragments; Postoperative Care; Postoperative Complications; Protein Precursors | 2004 |
Interaction between GLP-1 and CCK-33 in inhibiting food intake and appetite in men.
Topics: Adult; Appetite; Blood Glucose; Cholecystokinin; Cross-Over Studies; Double-Blind Method; Drug Combinations; Drug Interactions; Eating; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Male; Peptide Fragments; Protein Precursors; Satiety Response | 2004 |
One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and alpha- and beta-cell function and reduces endogenous glucose release in patients with type 2 diabetes.
Topics: Circadian Rhythm; Cross-Over Studies; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Hormones; Humans; Hypoglycemic Agents; Insulin Resistance; Islets of Langerhans; Liraglutide; Male; Middle Aged | 2004 |
Orlistat augments postprandial increases in glucagon-like peptide 1 in obese type 2 diabetic patients.
Topics: Adult; Aged; Anti-Obesity Agents; Cross-Over Studies; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Lactones; Male; Middle Aged; Obesity; Orlistat; Peptide Fragments; Protein Precursors; Single-Blind Method; Weight Loss | 2004 |
Glucagon-like peptide-2 inhibits antral emptying in man, but is not as potent as glucagon-like peptide-1.
Topics: Adult; Female; Gastric Emptying; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Hunger; Male; Middle Aged; Peptide Fragments; Peptides; Protein Precursors; Pyloric Antrum; Reference Values; Ultrasonography | 2004 |
Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial.
Topics: Blood Glucose; Body Weight; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Insulin; Liraglutide; Male; Middle Aged; Placebos; Treatment Outcome | 2004 |
Effects of intraduodenal fatty acids on appetite, antropyloroduodenal motility, and plasma CCK and GLP-1 in humans vary with their chain length.
Topics: Adult; Appetite; Cholecystokinin; Decanoic Acids; Double-Blind Method; Duodenum; Energy Intake; Fatty Acids; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Hormones; Humans; Infusions, Parenteral; Lauric Acids; Male; Manometry; Middle Aged; Peptide Fragments; Pilot Projects; Pressure; Protein Precursors; Pyloric Antrum; Pylorus; Sensation | 2004 |
Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans.
Topics: Adult; Amino Acids; Analysis of Variance; Animals; Caseins; Cattle; Cross-Over Studies; Gastric Emptying; Gastric Mucosa; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Male; Milk Proteins; Peptide Fragments; Peptide YY; Peptides; Protein Hydrolysates; Protein Precursors; Reproducibility of Results; Whey Proteins | 2004 |
Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women.
Topics: Adult; Blood Glucose; Dietary Carbohydrates; Fatty Acids, Nonesterified; Female; Fructose; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Leptin; Liver; Peptide Fragments; Peptide Hormones; Postprandial Period; Protein Precursors; Triglycerides | 2004 |
Glucagon-like peptide 1 induces natriuresis in healthy subjects and in insulin-resistant obese men.
Topics: Adult; Blood Glucose; Cross-Over Studies; Double-Blind Method; Drinking; Glomerular Filtration Rate; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Kidney Tubules, Proximal; Male; Natriuresis; Obesity; Peptide Fragments; Protein Precursors; Protons; Renin; Renin-Angiotensin System; Sodium; Thirst; Urine | 2004 |
Effect of variations in small intestinal glucose delivery on plasma glucose, insulin, and incretin hormones in healthy subjects and type 2 diabetes.
Topics: Biological Availability; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Duodenum; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Intestine, Small; Middle Aged; Osmolar Concentration; Peptide Fragments; Protein Precursors | 2004 |
[Glucagon 2004: homage to Roger Assan].
Topics: Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; History, 20th Century; Humans; Peptide Fragments; Peptides; Protein Precursors | 2004 |
Additive effects of glucagon-like peptide 1 and pioglitazone in patients with type 2 diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Peptide Fragments; Pioglitazone; Protein Precursors; Thiazolidinediones | 2004 |
The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes.
Topics: Blood Glucose; Body Composition; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Energy Metabolism; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Liraglutide; Male; Middle Aged; Placebos | 2004 |
Effects of glucagon-like peptide-1 on endothelial function in type 2 diabetes patients with stable coronary artery disease.
Topics: Adult; Brachial Artery; Coronary Circulation; Coronary Disease; Coronary Vessels; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelial Cells; Endothelium, Vascular; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Male; Middle Aged; Nitroglycerin; Peptide Fragments; Pilot Projects; Protein Precursors; Receptors, Glucagon; Regional Blood Flow; Vasodilation | 2004 |
Entero-insular axis in children with anorexia nervosa.
Topics: Adolescent; Anorexia Nervosa; Blood Glucose; Cholecystokinin; Eating; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Intestines; Pancreatic Polypeptide; Peptide Fragments; Protein Precursors; Signal Transduction | 2005 |
Evaluation of interactions between CCK and GLP-1 in their effects on appetite, energy intake, and antropyloroduodenal motility in healthy men.
Topics: Adolescent; Adult; Appetite; Cholecystokinin; Double-Blind Method; Drug Synergism; Duodenum; Energy Intake; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Male; Nausea; Peptide Fragments; Pressure; Protein Precursors; Pyloric Antrum; Reference Values; Satiety Response | 2005 |
Acute insulin responses to intravenous glucose and GLP-1 are independent of preceding high-frequency insulin pulse-defects induced by glucose entrainment in healthy humans.
Topics: Adaptation, Physiological; Adult; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Male; Peptide Fragments; Periodicity; Protein Precursors; Reference Values | 2005 |
alpha-Glucosidase inhibition (acarbose) fails to enhance secretion of glucagon-like peptide 1 (7-36 amide) and to delay gastric emptying in Type 2 diabetic patients.
Topics: Acarbose; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Peptide Fragments; Postprandial Period; Protein Precursors | 2005 |
Initially more rapid small intestinal glucose delivery increases plasma insulin, GIP, and GLP-1 but does not improve overall glycemia in healthy subjects.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hyperglycemia; Insulin; Intestine, Small; Male; Peptide Fragments; Postprandial Period; Protein Precursors; Reference Values | 2005 |
Normal secretion and action of the gut incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in young men with low birth weight.
Topics: Adult; Blood Glucose; C-Peptide; Eating; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Hyperglycemia; Infant, Low Birth Weight; Infant, Newborn; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors | 2005 |
Dose-related effects of lauric acid on antropyloroduodenal motility, gastrointestinal hormone release, appetite, and energy intake in healthy men.
Topics: Adult; Appetite; Cholecystokinin; Dose-Response Relationship, Drug; Double-Blind Method; Duodenum; Energy Intake; Enteral Nutrition; Gastrointestinal Hormones; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Humans; Lauric Acids; Male; Peptide Fragments; Protein Precursors; Pyloric Antrum; Pylorus | 2005 |
Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type 2 diabetic subjects.
Topics: Adult; Aged; Area Under Curve; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Proteins; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycemic Index; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Milk Proteins; Peptide Fragments; Postprandial Period; Protein Precursors; Whey Proteins | 2005 |
Glucagon-like peptide-1 release and satiety after a nutrient challenge in normal-weight and obese subjects.
Topics: Adult; Appetite Regulation; Blood Glucose; Cross-Over Studies; Dietary Fiber; Eating; Fatty Acids, Nonesterified; Female; Galactans; Galactose; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Mannans; Middle Aged; Obesity; Peptide Fragments; Plant Gums; Protein Precursors; Satiety Response | 2005 |
Effects of liraglutide (NN2211), a long-acting GLP-1 analogue, on glycaemic control and bodyweight in subjects with Type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Body Weight; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Liraglutide; Male; Middle Aged | 2005 |
Intraduodenal guar attenuates the fall in blood pressure induced by glucose in healthy older adults.
Topics: Aged; Biomarkers; Blood Glucose; Blood Pressure; Duodenum; Electrocardiography; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Galactans; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Heart Rate; Humans; Hypotension; Insulin; Male; Mannans; Peptide Fragments; Plant Gums; Postprandial Period; Protein Precursors; Reference Values; Single-Blind Method; Sweetening Agents; Time Factors | 2005 |
Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively.
Topics: Animals; Behavior, Animal; Diabetes Mellitus; Dose-Response Relationship, Drug; Double-Blind Method; Drug Combinations; Drug Synergism; Eating; Energy Intake; Feeding Behavior; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Immunohistochemistry; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Motor Activity; Obesity; Peptide Fragments; Peptide YY; Rats | 2005 |
Initial experience with GLP-1 treatment on metabolic control and myocardial function in patients with type 2 diabetes mellitus and heart failure.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Echocardiography, Doppler; Exercise Test; Glucagon; Glucagon-Like Peptide 1; Heart; Heart Failure; Humans; Infusions, Parenteral; Injections, Subcutaneous; Insulin; Male; Myocardial Contraction; Pilot Projects; Recombinant Proteins; Time Factors | 2004 |
The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes.
Topics: Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Activation; Enzyme Inhibitors; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Nitriles; Peptides; Pyrrolidines | 2006 |
Glucagon-like peptide 1 abolishes the postprandial rise in triglyceride concentrations and lowers levels of non-esterified fatty acids in humans.
Topics: Adult; Diet; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Postprandial Period; Stomach; Triglycerides | 2006 |
Effect of a high-protein breakfast on the postprandial ghrelin response.
Topics: Acetaminophen; Adolescent; Adult; Area Under Curve; Blood Glucose; Cholecystokinin; Cross-Over Studies; Dietary Proteins; Gastric Emptying; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Peptide Hormones; Postprandial Period; Satiation; Single-Blind Method; Surveys and Questionnaires; Time Factors | 2006 |
Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes.
Topics: Adamantane; Apolipoprotein B-48; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Intestinal Mucosa; Intestines; Lipids; Lipoproteins; Male; Middle Aged; Nitriles; Postprandial Period; Pyrrolidines; Time Factors; Treatment Outcome; Triglycerides; Vildagliptin | 2006 |
Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution.
Topics: Aged; Amylases; Blood Glucose; C-Peptide; Fatty Acids, Nonesterified; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Lipase; Male; Middle Aged; Pancreas; Pancreatitis, Chronic; Peptide Hydrolases; Postprandial Period; Steatorrhea; Triglycerides | 2007 |
Pharmacodynamics of vildagliptin in patients with type 2 diabetes during OGTT.
Topics: Adamantane; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycoproteins; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Nitriles; Pyrrolidines; Vildagliptin | 2007 |
The dipeptidyl peptidase 4 inhibitor vildagliptin does not accentuate glibenclamide-induced hypoglycemia but reduces glucose-induced glucagon-like peptide 1 and gastric inhibitory polypeptide secretion.
Topics: Adamantane; Adult; Algorithms; C-Peptide; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glyburide; Humans; Hydrocortisone; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Nitriles; Pyrrolidines; Vildagliptin | 2007 |
Effects of the dipeptidyl peptidase-IV inhibitor vildagliptin on incretin hormones, islet function, and postprandial glycemia in subjects with impaired glucose tolerance.
Topics: Adamantane; Blood Glucose; C-Peptide; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Humans; Inulin; Kinetics; Male; Nitriles; Placebos; Postprandial Period; Pyrrolidines; Vildagliptin | 2008 |
Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast.
Topics: Adiponectin; Adult; Biomarkers; Blood Glucose; Carbohydrates; Digestion; Fatty Acids, Nonesterified; Female; Food Analysis; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Inflammation; Insulin; Interleukin-6; Interleukin-8; Male; Satiety Response; Triglycerides | 2008 |
Effect of vildagliptin on glucagon concentration during meals in patients with type 1 diabetes.
Topics: Adamantane; Adult; Diabetes Mellitus, Type 1; Feeding Behavior; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Nitriles; Pyrrolidines; Vildagliptin | 2008 |
Oral glutamine increases circulating glucagon-like peptide 1, glucagon, and insulin concentrations in lean, obese, and type 2 diabetic subjects.
Topics: Administration, Oral; Adult; Area Under Curve; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glutamine; Humans; Insulin; Insulin Secretion; Male; Obesity; Thinness | 2009 |
The effect of a high-MUFA, low-glycaemic index diet and a low-fat diet on appetite and glucose metabolism during a 6-month weight maintenance period.
Topics: Adult; Analysis of Variance; Appetite Regulation; Area Under Curve; Blood Glucose; Body Mass Index; Body Weight; Diet, Fat-Restricted; Energy Intake; Fatty Acids, Monounsaturated; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glycemic Index; Humans; Insulin; Male; Obesity; Pancreatic Polypeptide; Peptide YY; Time Factors; Triglycerides | 2009 |
Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes.
Topics: Adamantane; Aged; Blood Glucose; Body Mass Index; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Nitriles; Pyrrolidines; Vildagliptin | 2009 |
The effect of exogenous glucagon-like peptide-1 on the glycaemic response to small intestinal nutrient in the critically ill: a randomised double-blind placebo-controlled cross over study.
Topics: Adult; Aged; Area Under Curve; Blood Glucose; Critical Illness; Cross-Over Studies; Double-Blind Method; Enteral Nutrition; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Hypoglycemia; Incretins; Infusions, Intravenous; Insulin; Male; Middle Aged | 2009 |
Acute effects of casein on postprandial lipemia and incretin responses in type 2 diabetic subjects.
Topics: Aged; Biomarkers; Blood Glucose; Caseins; Chylomicrons; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Diterpenes; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperlipidemias; Hypoglycemic Agents; Incretins; Insulin; Male; Middle Aged; Postprandial Period; Retinyl Esters; Time Factors; Triglycerides; Vitamin A | 2010 |
Orally administered glucagon-like peptide-1 affects glucose homeostasis following an oral glucose tolerance test in healthy male subjects.
Topics: Administration, Oral; Adult; Appetite; Blood Glucose; Caprylates; Cross-Over Studies; Double-Blind Method; Drug Carriers; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Homeostasis; Human Growth Hormone; Humans; Incretins; Insulin; Intestinal Absorption; Male; Peptide Fragments; Postprandial Period; Reference Values; Young Adult | 2009 |
Preserved inhibitory potency of GLP-1 on glucagon secretion in type 2 diabetes mellitus.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose Tolerance Test; Humans; Infusions, Intravenous; Insulin; Male; Middle Aged | 2009 |
Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?
Topics: Adult; Amyloid; Appetite; Body Mass Index; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 1; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islet Amyloid Polypeptide; Reference Values; Single-Blind Method | 2010 |
Effects of exogenous glucagon-like peptide-1 on gastric emptying and glucose absorption in the critically ill: relationship to glycemia.
Topics: 3-O-Methylglucose; Blood Glucose; Breath Tests; Critical Illness; Cross-Over Studies; Double-Blind Method; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Intensive Care Units; Respiration, Artificial | 2010 |
Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis.
Topics: Adult; Appetite; Blood Glucose; C-Peptide; Cross-Over Studies; Double-Blind Method; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Hunger; Immunoassay; Incretins; Insulin; Male; Peptide YY; Satiety Response | 2010 |
Pharmacokinetics and pharmacodynamics of inhaled GLP-1 (MKC253): proof-of-concept studies in healthy normal volunteers and in patients with type 2 diabetes.
Topics: Administration, Inhalation; Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Delivery Systems; Energy Intake; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Peptide Fragments | 2010 |
Pharmacokinetics and pharmacodynamics of vildagliptin in Japanese patients with type 2 diabetes.
Topics: Adamantane; Adult; Aged; Area Under Curve; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Nitriles; Pyrrolidines; Vildagliptin | 2010 |
Gastric emptying, glucose metabolism and gut hormones: evaluation of a common preoperative carbohydrate beverage.
Topics: Adult; Beverages; Blood Glucose; C-Peptide; Carbohydrates; Citrus; Cross-Over Studies; Dietary Carbohydrates; Female; Fruit; Gastric Emptying; Gastrointestinal Contents; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Polysaccharides; Preoperative Care | 2011 |
Gastric emptying, incretin hormone secretion, and postprandial glycemia in cystic fibrosis--effects of pancreatic enzyme supplementation.
Topics: Adult; Blood Glucose; Cystic Fibrosis; Dietary Carbohydrates; Dietary Fats; Double-Blind Method; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Incretins; Insulin; Lipase; Male; Pancreas; Young Adult | 2011 |
Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans.
Topics: Adult; Blood Glucose; C-Peptide; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Postprandial Period; Tachyphylaxis; Young Adult | 2011 |
Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Peptide Fragments; Triglycerides; Young Adult | 2011 |
Early improvement in glycemic control after bariatric surgery and its relationships with insulin, GLP-1, and glucagon secretion in type 2 diabetic patients.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Prospective Studies; Treatment Outcome; Weight Loss | 2011 |
Glutamine reduces postprandial glycemia and augments the glucagon-like peptide-1 response in type 2 diabetes patients.
Topics: Administration, Oral; Aged; Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glutamine; Humans; Hyperglycemia; Insulin; Insulin Secretion; Male; Middle Aged; Postprandial Period; Pyrazines; Sitagliptin Phosphate; Triazoles | 2011 |
Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin in older adults with type 2 diabetes mellitus.
Topics: Age Factors; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Insulin; Male; Pyrazines; Sitagliptin Phosphate; Treatment Outcome; Triazoles | 2011 |
Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin.
Topics: 1-Deoxynojirimycin; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Administration Schedule; Drug Therapy, Combination; Female; Food-Drug Interactions; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Postprandial Period; Pyrazines; Sitagliptin Phosphate; Triazoles | 2012 |
The role of the stomach in the control of appetite and the secretion of satiation peptides.
Topics: Adult; Appetite; Blood Glucose; Double-Blind Method; Duodenum; Female; Gastric Emptying; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Intubation, Gastrointestinal; Male; Neuropeptides; Peptide YY; Satiation; Stomach; Young Adult | 2012 |
Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects.
Topics: Adult; Blood Glucose; C-Peptide; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Intolerance; Glucose Tolerance Test; Humans; Incretins; Infusions, Intravenous; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Kinetics; Male; Severity of Illness Index; Young Adult | 2012 |
Metabolic effects of short-term GLP-1 treatment in insulin resistant heart failure patients.
Topics: Blood Glucose; Calorimetry, Indirect; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Tolerance Test; Heart Failure; Humans; Insulin; Insulin Resistance; Male; Middle Aged | 2012 |
Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance.
Topics: Adult; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hyperglycemia; Insulin Resistance; Insulin-Secreting Cells; Male; Middle Aged; Obesity; Obesity, Morbid; Postprandial Period; Time Factors | 2012 |
Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Male; Middle Aged; Pyrazines; Sitagliptin Phosphate; Triazoles | 2012 |
The effects of sitagliptin on gastric emptying in healthy humans - a randomised, controlled study.
Topics: Blood Glucose; Dipeptidyl-Peptidase IV Inhibitors; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Intestinal Absorption; Male; Postprandial Period; Pyrazines; Sitagliptin Phosphate; Triazoles; Young Adult | 2012 |
GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive K+ channel.
Topics: Adolescent; Adult; Blood Glucose; Congenital Hyperinsulinism; Cross-Over Studies; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Infant, Newborn; Insulin; Insulin Secretion; Islets of Langerhans; KATP Channels; Male; Mutation; Peptide Fragments; Pilot Projects; Receptors, Glucagon | 2012 |
Oxyntomodulin attenuates exendin-4-induced hypoglycemia in cattle.
Topics: Animals; Blood Glucose; Cattle; Cattle Diseases; Dose-Response Relationship, Drug; Exenatide; Glucagon; Glucagon-Like Peptide 1; Hypoglycemia; Insulin; Male; Oxyntomodulin; Peptides; Radioimmunoassay; Venoms | 2013 |
Coadministration of glucagon-like peptide-1 during glucagon infusion in humans results in increased energy expenditure and amelioration of hyperglycemia.
Topics: Adult; Calorimetry, Indirect; Cross-Over Studies; Double-Blind Method; Energy Metabolism; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Infusions, Intravenous; Male; Middle Aged | 2013 |
The effect of a bile acid sequestrant on glucose metabolism in subjects with type 2 diabetes.
Topics: Allylamine; Anticholesteremic Agents; Blood Glucose; C-Peptide; Colesevelam Hydrochloride; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Postprandial Period | 2013 |
Mosapride citrate, a 5-HT₄ receptor agonist, increased the plasma active and total glucagon-like peptide-1 levels in non-diabetic men.
Topics: Adult; Benzamides; Blood Glucose; Gastric Inhibitory Polypeptide; Gastrointestinal Agents; Gastrointestinal Tract; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Humans; Hypoglycemia; Hypoglycemic Agents; Incretins; Insulin; Male; Morpholines; Postprandial Period; Serotonin 5-HT4 Receptor Agonists; Up-Regulation | 2013 |
Postprandial gut hormone responses and glucose metabolism in cholecystectomized patients.
Topics: Adult; Aged; Bile Acids and Salts; Blood Glucose; C-Peptide; Cholecystectomy; Female; Gastric Emptying; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Postprandial Period | 2013 |
Pharmacodynamic characteristics of lixisenatide once daily versus liraglutide once daily in patients with type 2 diabetes insufficiently controlled on metformin.
Topics: Adult; Aged; C-Peptide; Diabetes Mellitus, Type 2; Drug Administration Schedule; Drug Resistance; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Incretins; Injections, Subcutaneous; Liraglutide; Male; Metformin; Middle Aged; Peptides | 2013 |
Effects of taurocholic acid on glycemic, glucagon-like peptide-1, and insulin responses to small intestinal glucose infusion in healthy humans.
Topics: Adult; Blood Glucose; C-Peptide; Cholagogues and Choleretics; Double-Blind Method; Glucagon; Glucagon-Like Peptide 1; Glucose; Health; Humans; Infusion Pumps; Insulin; Intestine, Small; Male; Taurocholic Acid | 2013 |
Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety.
Topics: Adult; Appetite; Blood Glucose; Cholecystokinin; Cross-Over Studies; Dietary Proteins; Dose-Response Relationship, Drug; Double-Blind Method; Energy Intake; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Insulin; Male; Pancreatic Hormones; Peptide YY; Satiation; Young Adult | 2013 |
A randomised trial of enteric-coated nutrient pellets to stimulate gastrointestinal peptide release and lower glycaemia in type 2 diabetes.
Topics: Area Under Curve; Blood Glucose; Colon; Cross-Over Studies; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Ileum; Insulin; Lauric Acids; Male; Metformin; Middle Aged; Tablets, Enteric-Coated; Time Factors | 2013 |
Intravenous ghrelin accelerates postoperative gastric emptying and time to first bowel movement in humans.
Topics: Administration, Intravenous; Aged; Blood Glucose; Defecation; Double-Blind Method; Female; Gastric Emptying; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Insulin; Male; Peptide YY; Postoperative Period; Satiation; Treatment Outcome | 2013 |
Effects of intraduodenal glutamine on incretin hormone and insulin release, the glycemic response to an intraduodenal glucose infusion, and antropyloroduodenal motility in health and type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Duodenum; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamine; Healthy Volunteers; Humans; Incretins; Insulin; Insulin Secretion; Male | 2013 |
The effect of exogenous GLP-1 on food intake is lost in male truncally vagotomized subjects with pyloroplasty.
Topics: Aged; Duodenal Ulcer; Eating; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Male; Meals; Pylorus; Vagotomy | 2013 |
Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects.
Topics: Antioxidants; Blood Glucose; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Fasting; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Male; Middle Aged; Obesity; Postprandial Period; Resveratrol; Stilbenes; Time Factors; Treatment Outcome | 2013 |
Characterisation of oral and i.v. glucose handling in truncally vagotomised subjects with pyloroplasty.
Topics: Acetaminophen; Adamantane; Aged; Area Under Curve; Case-Control Studies; Dipeptidyl-Peptidase IV Inhibitors; Duodenal Ulcer; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Insulin-Secreting Cells; Male; Nitriles; Pylorus; Pyrrolidines; Vagotomy, Truncal; Vildagliptin | 2013 |
Hyperglycemia associated with pasireotide: results from a mechanistic study in healthy volunteers.
Topics: Adolescent; Adult; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Hyperglycemia; Male; Middle Aged; Somatostatin | 2013 |
Pharmacokinetic and pharmacodynamic interaction of vildagliptin and voglibose in Japanese patients with Type 2 diabetes.
Topics: Adamantane; Adult; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Female; Glucagon; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Inositol; Insulin; Male; Middle Aged; Nitriles; Pyrrolidines; Vildagliptin | 2013 |
Effects of chenodeoxycholic acid on the secretion of gut peptides and fibroblast growth factors in healthy humans.
Topics: Adult; Bile Acids and Salts; C-Peptide; Chenodeoxycholic Acid; Cholecystokinin; Dipeptides; Double-Blind Method; Fibroblast Growth Factors; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Young Adult | 2013 |
Effects of intraduodenal lipid and protein on gut motility and hormone release, glycemia, appetite, and energy intake in lean men.
Topics: Adolescent; Adult; Appetite; Blood Glucose; Body Mass Index; Cholecystokinin; Cross-Over Studies; Dietary Fats; Dietary Proteins; Double-Blind Method; Energy Intake; Gastrointestinal Hormones; Gastrointestinal Motility; Gastrointestinal Tract; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; New Zealand; Postprandial Period; Satiation; Young Adult | 2013 |
Acute metabolic effects of exenatide in patients with type 1 diabetes with and without residual insulin to oral and intravenous glucose challenges.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Diabetes Mellitus, Type 1; Exenatide; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Middle Aged; Peptides; Venoms; Young Adult | 2014 |
Ingestion of thermally oxidized sunflower oil decreases postprandial lipemia mainly in younger individuals.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Cholesterol, HDL; Cross-Over Studies; Diet; Fatty Acids, Nonesterified; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperlipidemias; Insulin; Middle Aged; Plant Oils; Postprandial Period; Single-Blind Method; Sunflower Oil; Triglycerides; Young Adult | 2013 |
Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass.
Topics: Adult; Blood Glucose; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Resistance; Insulin Secretion; Male; Obesity, Morbid; Pancreas; Peptide Fragments; Postprandial Period; Treatment Outcome | 2013 |
Xenin-25 delays gastric emptying and reduces postprandial glucose levels in humans with and without type 2 diabetes.
Topics: Adult; Biomarkers; Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Male; Middle Aged; Missouri; Neurotensin; Postprandial Period; Receptors, Neurotensin; Time Factors; Treatment Outcome | 2014 |
Effect of linagliptin compared with glimepiride on postprandial glucose metabolism, islet cell function and vascular function parameters in patients with type 2 diabetes mellitus receiving ongoing metformin treatment.
Topics: Aged; Biomarkers; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Linagliptin; Male; Metformin; Middle Aged; Plasminogen Activator Inhibitor 1; Postprandial Period; Proinsulin; Purines; Quinazolines; Risk Factors; Sulfonylurea Compounds | 2014 |
Management of hyperglycemia associated with pasireotide (SOM230): healthy volunteer study.
Topics: Adamantane; Adolescent; Adult; Blood Glucose; Cyclohexanes; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Healthy Volunteers; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Liraglutide; Male; Maximum Tolerated Dose; Metformin; Middle Aged; Nateglinide; Nitriles; Phenylalanine; Prognosis; Pyrrolidines; Somatostatin; Vildagliptin; Young Adult | 2014 |
Lixisenatide resensitizes the insulin-secretory response to intravenous glucose challenge in people with type 2 diabetes--a study in both people with type 2 diabetes and healthy subjects.
Topics: Adult; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Healthy Volunteers; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Insulin Secretion; Male; Peptides; Postprandial Period; Treatment Outcome | 2014 |
Pharmacokinetic and pharmacodynamic interaction between gemigliptin and metformin in healthy subjects.
Topics: Adult; Blood Glucose; Cross-Over Studies; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Interactions; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidones; Pyrimidines; Young Adult | 2014 |
Exploratory trial of intranasal administration of glucagon-like peptide-1 in Japanese patients with type 2 diabetes.
Topics: Administration, Intranasal; Aged; Asian People; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Prospective Studies | 2014 |
Pancreatic enzyme supplementation improves the incretin hormone response and attenuates postprandial glycemia in adolescents with cystic fibrosis: a randomized crossover trial.
Topics: Adolescent; Blood Glucose; Child; Cross-Over Studies; Cystic Fibrosis; Enzyme Replacement Therapy; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Male; Pancrelipase; Postprandial Period | 2014 |
Gut hormone pharmacology of a novel GPR119 agonist (GSK1292263), metformin, and sitagliptin in type 2 diabetes mellitus: results from two randomized studies.
Topics: Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Male; Mesylates; Metformin; Middle Aged; Oxadiazoles; Peptide YY; Prognosis; Pyrazines; Receptors, G-Protein-Coupled; Sitagliptin Phosphate; Triazoles | 2014 |
Impaired incretin secretion and pancreatic dysfunction with older age and diabetes.
Topics: Adiponectin; Adipose Tissue; Adult; Aged; Aging; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Down-Regulation; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Insulin Resistance; Insulin Secretion; Male; Middle Aged; Pancreas; Postprandial Period; Up-Regulation | 2014 |
Differential effects of proteins and carbohydrates on postprandial blood pressure-related responses.
Topics: Blood Pressure; Body Mass Index; Cross-Over Studies; Dietary Carbohydrates; Dietary Sucrose; Double-Blind Method; Egg Proteins, Dietary; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hypertension; Insulin; Insulin Secretion; Male; Meals; Middle Aged; Milk Proteins; Nitric Oxide; Overweight; Pisum sativum; Plant Proteins, Dietary; Polysaccharides; Postprandial Period; Seeds | 2014 |
Effect of a test meal on meal responses of satiation hormones and their association to insulin resistance in obese adolescents.
Topics: Adolescent; Body Mass Index; Child; Female; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Islet Amyloid Polypeptide; Male; Meals; Metabolic Syndrome; Pediatric Obesity; Postprandial Period; Satiation | 2014 |
Coinfusion of low-dose GLP-1 and glucagon in man results in a reduction in food intake.
Topics: Adult; Cross-Over Studies; Eating; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Male; Young Adult | 2014 |
Effect of glucagon-like peptide-1 receptor antagonism on appetite and food intake in healthy men.
Topics: Adolescent; Adult; Appetite; Appetite Depressants; Cross-Over Studies; Double-Blind Method; Drinking Behavior; Energy Intake; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Infusions, Intravenous; Male; Peptide Fragments; Peptide YY; Postprandial Period; Receptors, Glucagon; Up-Regulation; Vomiting; Young Adult | 2014 |
Postprandial gallbladder emptying in patients with type 2 diabetes: potential implications for bile-induced secretion of glucagon-like peptide 1.
Topics: Adult; Aged; Area Under Curve; Bile; Biomarkers; Blood Glucose; C-Peptide; Case-Control Studies; Cholecystokinin; Denmark; Diabetes Mellitus, Type 2; Dietary Fats; Female; Gallbladder Emptying; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrins; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Male; Middle Aged; Postprandial Period; Receptors, G-Protein-Coupled | 2014 |
Comparison of the effects of slowly and rapidly absorbed carbohydrates on postprandial glucose metabolism in type 2 diabetes mellitus patients: a randomized trial.
Topics: Blood Glucose; C-Peptide; Carbohydrate Metabolism; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Double-Blind Method; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Insulin; Isomaltose; Male; Middle Aged; Postprandial Period; Sucrose | 2014 |
Lactobacillus paracasei subsp paracasei L. casei W8 suppresses energy intake acutely.
Topics: Adult; Animals; Appetite; Blood Glucose; Colon; Cross-Over Studies; Double-Blind Method; Energy Intake; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Ileum; Insulin; Lacticaseibacillus casei; Male; Meals; Microbiota; Postprandial Period; Probiotics; RNA, Messenger; Swine; Up-Regulation; Young Adult | 2014 |
Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes.
Topics: Adult; Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 1; Double-Blind Method; Drug Synergism; Fatty Acids, Nonesterified; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycerol; Hormones; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Treatment Outcome | 2015 |
The effect of liraglutide on endothelial function in patients with type 2 diabetes.
Topics: Acetylcholine; Aged; Blood Glucose; Blood Pressure; Body Weight; C-Peptide; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Hypoglycemic Agents; Insulin; Lipids; Liraglutide; Male; Middle Aged; Nitroprusside; Plethysmography | 2014 |
Effects of dipeptidyl peptidase IV inhibition on glycemic, gut hormone, triglyceride, energy expenditure, and energy intake responses to fat in healthy males.
Topics: Adamantane; Adolescent; Adult; Appetite Regulation; Cross-Over Studies; Dietary Fats; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Energy Intake; Energy Metabolism; Food-Drug Interactions; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Insulin; Insulin Secretion; Male; Middle Aged; Nitriles; Peptide Fragments; Peptide YY; Postprandial Period; Pyrrolidines; Vildagliptin; Young Adult | 2014 |
Albiglutide does not impair the counter-regulatory hormone response to hypoglycaemia: a randomized, double-blind, placebo-controlled, stepped glucose clamp study in subjects with type 2 diabetes mellitus.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Down-Regulation; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Pancreas; Recombinant Proteins; Up-Regulation | 2015 |
Sucralose enhances GLP-1 release and lowers blood glucose in the presence of carbohydrate in healthy subjects but not in patients with type 2 diabetes.
Topics: Adult; Area Under Curve; Aspartame; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Healthy Volunteers; Humans; Insulin; Male; Middle Aged; Sucrose; Sweetening Agents | 2015 |
Addition of sitagliptin or metformin to insulin monotherapy improves blood glucose control via different effects on insulin and glucagon secretion in hyperglycemic Japanese patients with type 2 diabetes.
Topics: Aged; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Resistance; Drug Therapy, Combination; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Postprandial Period; Sitagliptin Phosphate | 2015 |
Postprandial glucose, insulin and incretin responses to different carbohydrate tolerance tests.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; C-Peptide; China; Cross-Over Studies; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Incretins; Insulin; Male; Middle Aged; Postprandial Period; Predictive Value of Tests; Time Factors; Young Adult | 2015 |
Very short-term effects of the dipeptidyl peptidase-4 inhibitor sitagliptin on the secretion of insulin, glucagon, and incretin hormones in Japanese patients with type 2 diabetes mellitus: analysis of meal tolerance test data.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Food; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Insulin Secretion; Male; Middle Aged; Postprandial Period; Sitagliptin Phosphate | 2014 |
Accelerated intestinal glucose absorption in morbidly obese humans: relationship to glucose transporters, incretin hormones, and glycemia.
Topics: 3-O-Methylglucose; Adult; Blood Glucose; Female; Gastric Inhibitory Polypeptide; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transport Proteins, Facilitative; Humans; Incretins; Insulin; Intestinal Absorption; Male; Middle Aged; Obesity, Morbid; Time Factors | 2015 |
Incretin effect after oral amino acid ingestion in humans.
Topics: Administration, Oral; Adult; Amino Acids; Blood Glucose; C-Peptide; Eating; Electrolytes; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Incretins; Insulin; Insulin Secretion; Male; Solutions; Young Adult | 2015 |
The effects of TNF-α on GLP-1-stimulated plasma glucose kinetics.
Topics: Adult; Blood Glucose; Body Temperature; C-Peptide; Cross-Over Studies; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Interleukin-6; Kinetics; Male; Recombinant Proteins; Tumor Necrosis Factor-alpha; Young Adult | 2015 |
Effects of sitagliptin on counter-regulatory and incretin hormones during acute hypoglycaemia in patients with type 1 diabetes: a randomized double-blind placebo-controlled crossover study.
Topics: Adolescent; Adult; Cross-Over Studies; Diabetes Mellitus, Type 1; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Growth Hormone; Humans; Hypoglycemia; Incretins; Male; Middle Aged; Sitagliptin Phosphate; Young Adult | 2015 |
A high-protein breakfast induces greater insulin and glucose-dependent insulinotropic peptide responses to a subsequent lunch meal in individuals with type 2 diabetes.
Topics: Adult; Blood Glucose; Body Mass Index; Breakfast; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet; Diet Records; Dietary Carbohydrates; Dietary Proteins; Energy Intake; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Insulin; Lunch; Male; Middle Aged; Postprandial Period; Single-Blind Method; Young Adult | 2015 |
Metabolic responses of healthy or prediabetic adults to bovine whey protein and sodium caseinate do not differ.
Topics: Adult; Amino Acids; Blood Glucose; C-Peptide; Carnitine; Caseins; Dietary Carbohydrates; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Healthy Volunteers; Humans; Insulin; Male; Milk Proteins; Postprandial Period; Prediabetic State; Single-Blind Method; Whey Proteins | 2015 |
Comparison of appetite responses to high- and low-glycemic index postexercise meals under matched insulinemia and fiber in type 1 diabetes.
Topics: Adult; Appetite Regulation; Combined Modality Therapy; Cross-Over Studies; Diabetes Mellitus, Type 1; Diet, Diabetic; Dietary Fiber; Drug Therapy, Combination; Exercise; Glucagon; Glucagon-Like Peptide 1; Glycemic Index; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Insulin Aspart; Insulin Glargine; Insulin, Long-Acting; Jogging; Male; Meals; Postprandial Period | 2015 |
Dairy proteins, dairy lipids, and postprandial lipemia in persons with abdominal obesity (DairyHealth): a 12-wk, randomized, parallel-controlled, double-blinded, diet intervention study.
Topics: Adult; Aged; Apolipoprotein B-48; Blood Glucose; Caseins; Chylomicrons; Dairy Products; Dietary Fats; Dietary Proteins; Dietary Supplements; Double-Blind Method; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperlipidemias; Insulin; Lipid Metabolism; Male; Meals; Middle Aged; Milk Proteins; Nutrition Assessment; Obesity, Abdominal; Postprandial Period; Triglycerides; Whey Proteins | 2015 |
Counter-regulatory hormone responses to hypoglycaemia in people with type 1 diabetes after 4 weeks of treatment with liraglutide adjunct to insulin: a randomized, placebo-controlled, double-blind, crossover trial.
Topics: Adult; Body Weight; Cross-Over Studies; Diabetes Mellitus, Type 1; Double-Blind Method; Drug Therapy, Combination; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Clamp Technique; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin; Liraglutide; Male; Middle Aged | 2015 |
Preserved Insulin Secretory Capacity and Weight Loss Are the Predominant Predictors of Glycemic Control in Patients With Type 2 Diabetes Randomized to Roux-en-Y Gastric Bypass.
Topics: Adiponectin; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Middle Aged; Obesity; Treatment Outcome; Weight Loss | 2015 |
Postprandial incretin and islet hormone responses and dipeptidyl-peptidase 4 enzymatic activity in patients with maturity onset diabetes of the young.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Male; Middle Aged; Postprandial Period | 2015 |
Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose-tolerant humans: a proof of concept.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Limosilactobacillus reuteri; Male; Middle Aged; Obesity; Oxidative Stress; Pilot Projects; Probiotics; Prospective Studies; Protein Precursors | 2015 |
The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1.
Topics: Acetylcholine; Adult; Atropine; Blood Glucose; Denmark; Efferent Pathways; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Healthy Volunteers; Heart Rate; Humans; Infusions, Intravenous; Insulin; Male; Muscarinic Antagonists; Single-Blind Method; Somatostatin; Synaptic Transmission; Time Factors; Vagus Nerve; Young Adult | 2015 |
The 2-monoacylglycerol moiety of dietary fat appears to be responsible for the fat-induced release of GLP-1 in humans.
Topics: Adult; Blood Glucose; Body Mass Index; C-Peptide; Cholecystokinin; Cross-Over Studies; Daucus carota; Dietary Fats; Fats; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glycerides; Humans; Insulin; Male; Monoglycerides; Neurotensin; Oleic Acid; Olive Oil; Peptide YY; Receptors, G-Protein-Coupled; Single-Blind Method; Triglycerides; Young Adult | 2015 |
Does GLP-1 suppress its own basal secretion?
Topics: Adult; Basal Metabolism; Blood Glucose; Feedback, Physiological; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Obesity; Peptide Fragments; Peptides; Thinness | 2016 |
Fasting until noon triggers increased postprandial hyperglycemia and impaired insulin response after lunch and dinner in individuals with type 2 diabetes: a randomized clinical trial.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Breakfast; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Fasting; Fatty Acids, Nonesterified; Female; Follow-Up Studies; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperglycemia; Insulin; Lunch; Male; Meals; Middle Aged; Postprandial Period | 2015 |
Effects of intraduodenal infusion of the branched-chain amino acid leucine on ad libitum eating, gut motor and hormone functions, and glycemia in healthy men.
Topics: Adolescent; Adult; Appetite; Blood Glucose; Body Mass Index; Cholecystokinin; Dose-Response Relationship, Drug; Double-Blind Method; Duodenum; Eating; Energy Intake; Gastrointestinal Hormones; Gastrointestinal Motility; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Leucine; Male; Peptide YY; Young Adult | 2015 |
Effect of Oxyntomodulin, Glucagon, GLP-1, and Combined Glucagon +GLP-1 Infusion on Food Intake, Appetite, and Resting Energy Expenditure.
Topics: Acetaminophen; Adolescent; Adult; Analgesics, Non-Narcotic; Appetite; Cross-Over Studies; Double-Blind Method; Drug Interactions; Eating; Energy Metabolism; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Male; Oxygen Consumption; Oxyntomodulin; Rest; Young Adult | 2015 |
Cephalic phase secretion of insulin and other enteropancreatic hormones in humans.
Topics: Adult; Biomarkers; Blood Glucose; Denmark; Eating; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Heart Rate; Humans; Insulin; Insulin Secretion; Intestinal Mucosa; Intestinal Secretions; Intestines; Male; Muscarinic Antagonists; Pancreas; Pancreatic Polypeptide; Postprandial Period; Time Factors; Vagus Nerve; Young Adult | 2016 |
Effect of the GLP-1 Receptor Agonist Lixisenatide on Counterregulatory Responses to Hypoglycemia in Subjects With Insulin-Treated Type 2 Diabetes.
Topics: Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hydrocortisone; Hypoglycemia; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Peptides | 2016 |
Acute load-dependent effects of oral whey protein on gastric emptying, gut hormone release, glycemia, appetite, and energy intake in healthy men.
Topics: Adolescent; Adult; Appetite Regulation; Beverages; Blood Glucose; Breakfast; Cholecystokinin; Cross-Over Studies; Double-Blind Method; Energy Intake; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Lunch; Male; Postprandial Period; Whey Proteins; Young Adult | 2015 |
[Clinical observation on the combined therapy of sitagliptin with insulin for patients with brittle diabetes].
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Therapy, Combination; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Sitagliptin Phosphate | 2015 |
Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: a randomised, controlled crossover, exploratory trial.
Topics: Adult; Aged; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Incretins; Insulin; Japan; Male; Meals; Middle Aged; Postprandial Period | 2016 |
Diabetic and nondiabetic patients with nonalcoholic fatty liver disease have an impaired incretin effect and fasting hyperglucagonaemia.
Topics: Adult; Blood Glucose; C-Reactive Protein; Diabetes Mellitus, Type 2; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Humans; Incretins; Insulin; Male; Middle Aged; Non-alcoholic Fatty Liver Disease | 2016 |
Effect of meal composition on postprandial glucagon-like peptide-1, insulin, glucagon, C-peptide, and glucose responses in overweight/obese subjects.
Topics: Adolescent; Adult; Aged; Appetite; Blood Glucose; Body Mass Index; C-Peptide; Cross-Over Studies; Exercise; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Male; Meals; Mental Recall; Middle Aged; Obesity; Overweight; Postprandial Period; Young Adult | 2017 |
The effect of pregnane X receptor agonists on postprandial incretin hormone secretion in rats and humans.
Topics: Adolescent; Adult; Animals; Blood Glucose; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Male; Peptide YY; Postprandial Period; Pregnane X Receptor; Pregnenolone Carbonitrile; Rats; Rats, Sprague-Dawley; Receptors, Steroid; Rifampin; Young Adult | 2015 |
A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes.
Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Insulin; Male; Metformin; Middle Aged; Nitriles; Postprandial Period; Pyrrolidines; Vildagliptin; Whey Proteins | 2016 |
Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery.
Topics: Adult; Blood Glucose; C-Peptide; Cross-Over Studies; Enzyme-Linked Immunosorbent Assay; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Linear Models; Male; Obesity; Peptide Fragments; Postprandial Period; Single-Blind Method; Sitagliptin Phosphate | 2016 |
Improving Effect of the Acute Administration of Dietary Fiber-Enriched Cereals on Blood Glucose Levels and Gut Hormone Secretion.
Topics: Adult; Aged; Area Under Curve; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Dietary Fiber; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperglycemia; Insulin; Intestinal Mucosa; Male; Middle Aged; ROC Curve | 2016 |
Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men.
Topics: Appetite; Bile Acids and Salts; Blood Glucose; Body Mass Index; Bread; Cross-Over Studies; Dietary Fiber; Flour; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Male; Particle Size; Postprandial Period; Triticum; Young Adult | 2017 |
Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
Topics: 3-Hydroxybutyric Acid; Algorithms; Benzhydryl Compounds; C-Reactive Protein; Carbohydrate Metabolism; Diabetes Mellitus, Type 2; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Glucosides; Glycosuria; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Lipid Metabolism; Lipolysis; Membrane Transport Modulators; Renal Elimination; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Time Factors | 2016 |
GLP-1 Restores Altered Insulin and Glucagon Secretion in Posttransplantation Diabetes.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Incretins; Infusions, Intravenous; Insulin; Insulin Secretion; Kidney Transplantation; Male; Middle Aged; Proinsulin | 2016 |
Mechanisms Regulating Insulin Response to Intragastric Glucose in Lean and Non-Diabetic Obese Subjects: A Randomized, Double-Blind, Parallel-Group Trial.
Topics: Adult; Blood Glucose; Body Mass Index; Body Weight; C-Peptide; Case-Control Studies; Diabetes Mellitus; Double-Blind Method; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Incretins; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Young Adult | 2016 |
Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1.
Topics: Adult; Blood Glucose; Female; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Male; Peptide YY; Postprandial Period; Young Adult | 2016 |
Effects of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Alanine Transaminase; Amino Acids; Aspartate Aminotransferases; beta-Alanine; Blood Glucose; C-Peptide; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Pyrazoles; Receptors, Glucagon; Sulfonylurea Compounds | 2016 |
Metabolic responses to xenin-25 are altered in humans with Roux-en-Y gastric bypass surgery.
Topics: Adolescent; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Diarrhea; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Neuropeptide Y; Neurotensin; Pancreatic Polypeptide | 2016 |
Hormonal Responses to Cholinergic Input Are Different in Humans with and without Type 2 Diabetes Mellitus.
Topics: Administration, Oral; Adult; Bethanechol; Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Hormones; Humans; Insulin; Islets of Langerhans; Male; Middle Aged; Muscarinic Agonists; Neurotensin; Non-Randomized Controlled Trials as Topic; Pancreatic Polypeptide; Postprandial Period | 2016 |
Gastric Bypass Reduces Symptoms and Hormonal Responses in Hypoglycemia.
Topics: Adult; Blood Glucose; Catecholamines; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Hydrocortisone; Hypoglycemia; Insulin; Male; Middle Aged; Obesity, Morbid | 2016 |
Endobarrier® in Grade I Obese Patients with Long-Standing Type 2 Diabetes: Role of Gastrointestinal Hormones in Glucose Metabolism.
Topics: Adult; Bariatric Surgery; Blood Glucose; Device Removal; Diabetes Mellitus, Type 2; Endoscopy, Gastrointestinal; Female; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Male; Middle Aged; Obesity, Morbid; Prosthesis Implantation | 2017 |
Intragastric administration of leucine or isoleucine lowers the blood glucose response to a mixed-nutrient drink by different mechanisms in healthy, lean volunteers.
Topics: Adult; Beverages; Blood Glucose; Body Mass Index; C-Peptide; Cholecystokinin; Cross-Over Studies; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Energy Intake; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Healthy Volunteers; Humans; Insulin; Isoleucine; Leucine; Male; Young Adult | 2016 |
Addition of a dipeptidyl peptidase-4 inhibitor, sitagliptin, to ongoing therapy with the glucagon-like peptide-1 receptor agonist liraglutide: A randomized controlled trial in patients with type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Liraglutide; Male; Metformin; Middle Aged; Sitagliptin Phosphate; Treatment Outcome | 2017 |
Third Exposure to a Reduced Carbohydrate Meal Lowers Evening Postprandial Insulin and GIP Responses and HOMA-IR Estimate of Insulin Resistance.
Topics: 3-Hydroxybutyric Acid; Aged; Blood Glucose; Dietary Carbohydrates; Energy Intake; Energy Metabolism; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Insulin; Insulin Resistance; Middle Aged; Postprandial Period; Sedentary Behavior | 2016 |
Effects of gemigliptin, a dipeptidyl peptidase-4 inhibitor, on lipid metabolism and endotoxemia after a high-fat meal in patients with type 2 diabetes.
Topics: Adiponectin; Adult; Aged; Apolipoprotein B-100; Apolipoprotein B-48; Blood Glucose; C-Reactive Protein; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Cytokines; Diabetes Mellitus, Type 2; Diet, High-Fat; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Endotoxemia; Endotoxins; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Interleukin-6; Lipid Metabolism; Male; Middle Aged; Piperidones; Postprandial Period; Pyrimidines; RNA, Messenger; Subcutaneous Fat, Abdominal; Transcriptome; Triglycerides; Tumor Necrosis Factor-alpha | 2017 |
Effect of exenatide on postprandial glucose fluxes, lipolysis, and ß-cell function in non-diabetic, morbidly obese patients.
Topics: Adipose Tissue; Adult; Blood Glucose; Exenatide; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Lipolysis; Liver; Male; Middle Aged; Obesity, Morbid; Peptides; Postprandial Period; Venoms | 2017 |
Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Male; Middle Aged; Peptide Fragments; Surveys and Questionnaires | 2017 |
Targeted metabolomics reveals differences in the extended postprandial plasma metabolome of healthy subjects after intake of whole-grain rye porridges versus refined wheat bread.
Topics: Adult; Appetite; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Magnetic Resonance Spectroscopy; Male; Metabolomics; Middle Aged; Postprandial Period; Secale; Triticum; Whole Grains | 2017 |
Chenodeoxycholic acid stimulates glucagon-like peptide-1 secretion in patients after Roux-en-Y gastric bypass.
Topics: Administration, Oral; Adult; Bile Acids and Salts; Blood Glucose; C-Peptide; Chenodeoxycholic Acid; Cross-Over Studies; Female; Fibroblast Growth Factors; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Ursodeoxycholic Acid | 2017 |
Effect of GLP-1 and GIP on C-peptide secretion after glucagon or mixed meal tests: Significance in assessing B-cell function in diabetes.
Topics: Adult; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 2; Diagnostic Techniques, Endocrine; Eating; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin-Secreting Cells; Male; Meals; Stimulation, Chemical | 2017 |
A walnut-containing meal had similar effects on early satiety, CCK, and PYY, but attenuated the postprandial GLP-1 and insulin response compared to a nut-free control meal.
Topics: Adult; Aged; Cholecystokinin; Cross-Over Studies; Diet; Energy Intake; Feeding Behavior; Female; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Juglans; Male; Meals; Middle Aged; Nuts; Obesity; Peptide YY; Peptides; Postprandial Period; Satiation | 2017 |
Effect of canagliflozin on circulating active GLP-1 levels in patients with type 2 diabetes: a randomized trial.
Topics: Aged; Blood Glucose; Canagliflozin; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Treatment Outcome | 2017 |
Effect of Age on Blood Glucose and Plasma Insulin, Glucagon, Ghrelin, CCK, GIP, and GLP-1 Responses to Whey Protein Ingestion.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aging; Beverages; Blood Glucose; Cholecystokinin; Cross-Over Studies; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; South Australia; Time Factors; Whey Proteins; Young Adult | 2017 |
Pre-Meal Effect of Whey Proteins on Metabolic Parameters in Subjects with and without Type 2 Diabetes: A Randomized, Crossover Trial.
Topics: Acetaminophen; Aged; Apolipoprotein B-48; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Diet; Fatty Acids, Nonesterified; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Insulin; Male; Meals; Middle Aged; Postprandial Period; Triglycerides; Whey Proteins | 2018 |
Glucose-lowering effects and mechanisms of the bile acid-sequestering resin sevelamer.
Topics: Aged; Area Under Curve; Bile Acids and Salts; Blood Glucose; C-Peptide; Chelating Agents; Cholecystokinin; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Energy Metabolism; Female; Fibroblast Growth Factors; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrointestinal Microbiome; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; RNA, Ribosomal, 16S; Sequestering Agents; Sevelamer; Triglycerides | 2018 |
Rate of appearance of amino acids after a meal regulates insulin and glucagon secretion in patients with type 2 diabetes: a randomized clinical trial.
Topics: Aged; Amino Acids; Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Protein; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged | 2018 |
Postprandial Glycaemic, Hormonal and Satiety Responses to Rice and Kiwifruit Preloads in Chinese Adults: A Randomised Controlled Crossover Trial.
Topics: Actinidia; Adolescent; Adult; Aged; Asian People; Blood Glucose; Body Mass Index; Cross-Over Studies; Diet; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Female; Fruit; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glycemic Index; Humans; Insulin; Male; Meals; Middle Aged; Oryza; Postprandial Period; Satiety Response; Young Adult | 2018 |
A whey/guar "preload" improves postprandial glycaemia and glycated haemoglobin levels in type 2 diabetes: A 12-week, single-blind, randomized, placebo-controlled trial.
Topics: Aged; Blood Glucose; Body Composition; Body Weight; Diabetes Mellitus, Type 2; Diet, Diabetic; Energy Intake; Female; Galactans; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Mannans; Metformin; Middle Aged; Plant Gums; Postprandial Period; Single-Blind Method; Whey Proteins | 2019 |
Glucose Appearance Rate Rather than the Blood Glucose Concentrations Explains Differences in Postprandial Insulin Responses between Wholemeal Rye and Refined Wheat Breads-Results from A Cross-Over Meal Study.
Topics: Adolescent; Adult; Blood Glucose; Bread; C-Peptide; Chromatography, High Pressure Liquid; Cross-Over Studies; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Mass Spectrometry; Postprandial Period; Secale; Triticum | 2019 |
Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study.
Topics: Adult; Aged; Appetite; Blood Glucose; Calorimetry; Cross-Over Studies; Double-Blind Method; Energy Intake; Energy Metabolism; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Obesity; Overweight; Weight Loss | 2019 |
Augmented GLP-1 Secretion as Seen After Gastric Bypass May Be Obtained by Delaying Carbohydrate Digestion.
Topics: Adult; Carbohydrate Metabolism; Cross-Over Studies; Digestion; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Peptide YY; Single-Blind Method | 2019 |
Mechanisms of early glucose regulation disturbance after out-of-hospital cardiopulmonary resuscitation: An explorative prospective study.
Topics: Aged; Aged, 80 and over; Blood Glucose; Cardiopulmonary Resuscitation; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Insulin; Male; Middle Aged; Out-of-Hospital Cardiac Arrest; Prospective Studies | 2019 |
Postprandial levels of GLP-1, GIP and glucagon after 2 years of weight loss with a Paleolithic diet: a randomised controlled trial in healthy obese women.
Topics: Aged; Biomarkers; Diet, Paleolithic; Energy Intake; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Middle Aged; Obesity; Postprandial Period; Weight Loss | 2019 |
Effects of GLP-1 on counter-regulatory responses during hypoglycemia after GBP surgery.
Topics: Adult; Blood Glucose; Catecholamines; Cross-Over Studies; Exenatide; Female; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Heart Rate; Human Growth Hormone; Humans; Hydrocortisone; Hypoglycemia; Incretins; Male; Middle Aged; Parasympathetic Nervous System; Postoperative Period; Sympathetic Nervous System | 2019 |
Effects of Nicotinamide Riboside on Endocrine Pancreatic Function and Incretin Hormones in Nondiabetic Men With Obesity.
Topics: Blood Glucose; C-Peptide; Double-Blind Method; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Islets of Langerhans; Male; Middle Aged; Niacinamide; Obesity; Pyridinium Compounds | 2019 |
Changes in Bone Mineral Density in Patients with Type 2 Diabetes After Different Bariatric Surgery Procedures and the Role of Gastrointestinal Hormones.
Topics: Adult; Bariatric Surgery; Bone and Bones; Bone Density; Bone Remodeling; Diabetes Mellitus, Type 2; Female; Femur Neck; Follow-Up Studies; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Obesity, Morbid; Treatment Outcome | 2020 |
A ketone monoester drink reduces the glycemic response to an oral glucose challenge in individuals with obesity: a randomized trial.
Topics: 3-Hydroxybutyric Acid; Adult; Blood Glucose; Dietary Supplements; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycemic Index; Humans; Ketones; Male; Middle Aged; Obesity | 2019 |
Efficacy, Safety, and Mechanistic Insights of Cotadutide, a Dual Receptor Glucagon-Like Peptide-1 and Glucagon Agonist.
Topics: Biomarkers; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Follow-Up Studies; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Male; Middle Aged; Obesity; Overweight; Peptides; Prognosis; Receptors, Glucagon | 2020 |
Effect of the Incretin Hormones on the Endocrine Pancreas in End-Stage Renal Disease.
Topics: Adult; Denmark; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Secretion; Islets of Langerhans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 2020 |
Subjects with high fasting insulin also have higher postprandial GLP-1 and glucagon levels than controls with lower insulin.
Topics: Adult; Cross-Over Studies; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Postprandial Period; Young Adult | 2019 |
Intragastric administration of the bitter tastant quinine lowers the glycemic response to a nutrient drink without slowing gastric emptying in healthy men.
Topics: Adult; Beverages; Biomarkers; Blood Glucose; Double-Blind Method; Energy Intake; Food, Formulated; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Healthy Volunteers; Humans; Hypoglycemic Agents; Insulin; Male; Postprandial Period; Quinine; Taste; Time Factors; Young Adult | 2020 |
No Acute Effects of Exogenous Glucose-Dependent Insulinotropic Polypeptide on Energy Intake, Appetite, or Energy Expenditure When Added to Treatment With a Long-Acting Glucagon-Like Peptide 1 Receptor Agonist in Men With Type 2 Diabetes.
Topics: Adult; Aged; Appetite; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Energy Intake; Energy Metabolism; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Insulin; Male; Middle Aged | 2020 |
Effects of Glucagon-like Peptide-1 on the Reproductive Axis in Healthy Men.
Topics: Adult; Biomarkers; Cross-Over Studies; Follow-Up Studies; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin Secretion; Male; Prognosis; Reproduction; Single-Blind Method; Young Adult | 2020 |
The effect of acute dual SGLT1/SGLT2 inhibition on incretin release and glucose metabolism after gastric bypass surgery.
Topics: Blood Glucose; C-Peptide; Canagliflozin; Cross-Over Studies; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Incretins; Insulin; Middle Aged; Pancreatic Polypeptide; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2020 |
Late-night-dinner deteriorates postprandial glucose and insulin whereas consuming dinner dividedly ameliorates them in patients with type 2 diabetes: A randomized crossover clinical trial.
Topics: Aged; Area Under Curve; Cross-Over Studies; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Japan; Male; Meals; Middle Aged; Postprandial Period | 2020 |
Is pasireotide-induced diabetes mellitus predictable? A pilot study on the effect of a single dose of pasireotide on glucose homeostasis.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Female; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Insulin; Male; Middle Aged; Pilot Projects; Somatostatin | 2020 |
Effects of L-Phenylalanine on Energy Intake and Glycaemia-Impacts on Appetite Perceptions, Gastrointestinal Hormones and Gastric Emptying in Healthy Males.
Topics: Appetite; Beverages; Blood Glucose; Cholecystokinin; Double-Blind Method; Energy Intake; Gastric Emptying; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Peptide YY; Phenylalanine; Young Adult | 2020 |
Sweetness Perception is not Involved in the Regulation of Blood Glucose after Oral Application of Sucrose and Glucose Solutions in Healthy Male Subjects.
Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucose; Healthy Volunteers; Humans; Insulin; Male; Middle Aged; Sucrose; Taste Perception; Young Adult | 2021 |
Effect of the Natural Sweetener Xylitol on Gut Hormone Secretion and Gastric Emptying in Humans: A Pilot Dose-Ranging Study.
Topics: Adult; Blood Glucose; Cholecystokinin; Cross-Over Studies; Dipeptides; Double-Blind Method; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Lipids; Male; Sweetening Agents; Uric Acid; Xylitol; Young Adult | 2021 |
Acute Nutritional Ketosis and Its Implications for Plasma Glucose and Glucoregulatory Peptides in Adults with Prediabetes: A Crossover Placebo-Controlled Randomized Trial.
Topics: 3-Hydroxybutyric Acid; Adult; Aged; Blood Glucose; C-Peptide; Cross-Over Studies; Dietary Supplements; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Islet Amyloid Polypeptide; Ketosis; Male; Middle Aged; Prediabetic State; Single-Blind Method | 2021 |
Glucagonostatic Potency of GLP-1 in Patients With Type 2 Diabetes, Patients With Type 1 Diabetes, and Healthy Control Subjects.
Topics: Blood Glucose; Denmark; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glycated Hemoglobin; Healthy Volunteers; Humans; Male; Middle Aged; Treatment Outcome | 2021 |
Comparison of the acute metabolic effect of different infant formulas and human milk in healthy adults: a randomized trial.
Topics: Adult; Blood Glucose; C-Peptide; Cross-Over Studies; Dietary Proteins; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Healthy Volunteers; Humans; Infant; Infant Formula; Insulin; Lipids; Male; Milk, Human; Postprandial Period; Triglycerides; Whey Proteins; Young Adult | 2021 |
Effects of Manipulating Circulating Bile Acid Concentrations on Postprandial GLP-1 Secretion and Glucose Metabolism After Roux-en-Y Gastric Bypass.
Topics: Adult; Bile Acids and Salts; Blood Glucose; C-Peptide; Colesevelam Hydrochloride; Female; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Male; Middle Aged; Neurotensin; Obesity, Morbid; Postprandial Period; Single-Blind Method | 2021 |
The Postprandial Glycaemic and Hormonal Responses Following the Ingestion of a Novel, Ready-to-Drink Shot Containing a Low Dose of Whey Protein in Centrally Obese and Lean Adult Males: A Randomised Controlled Trial.
Topics: Adult; Blood Glucose; C-Peptide; Cross-Over Studies; Eating; England; Food, Formulated; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Obesity, Abdominal; Postprandial Period; Thinness; Whey Proteins; Young Adult | 2021 |
Effects of Dietary Fat and Protein on Glucoregulatory Hormones in Adolescents and Young Adults With Type 1 Diabetes.
Topics: Adult; Australia; Biomarkers; Blood Glucose; C-Peptide; Cross-Over Studies; Diabetes Mellitus, Type 1; Dietary Fats; Dietary Proteins; Female; Follow-Up Studies; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Insulin; Male; Meals; Prognosis | 2022 |
The glucagon receptor antagonist LY2409021 has no effect on postprandial glucose in type 2 diabetes.
Topics: Adult; Aged; Biphenyl Compounds; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Postprandial Period; Receptors, Glucagon | 2022 |
Oral lactate slows gastric emptying and suppresses appetite in young males.
Topics: Administration, Intravenous; Administration, Oral; Adult; Appetite; Appetite Depressants; Eating; Gastric Emptying; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Growth Differentiation Factor 15; Healthy Volunteers; Humans; Insulin; Lactic Acid; Male; Young Adult | 2022 |
Effects of intraduodenal infusion of lauric acid and L-tryptophan, alone and combined, on glucoregulatory hormones, gastric emptying and glycaemia in healthy men.
Topics: Adult; Blood Glucose; C-Peptide; Cholecystokinin; Double-Blind Method; Energy Intake; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Lauric Acids; Male; Tryptophan; Young Adult | 2022 |
Methods paper: Performance characteristics of novel assays for circulating levels of proglucagon-derived peptides and validation in a placebo controlled cross-over randomized clinical trial.
Topics: C-Peptide; Caffeine; Coffee; Glicentin; Glucagon; Glucagon-Like Peptide 1; Humans; Oxyntomodulin; Peptides; Proglucagon; Water | 2022 |
The sodium-glucose cotransporter 2 inhibitor ipragliflozin improves liver function and insulin resistance in Japanese patients with type 2 diabetes.
Topics: Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucosides; Humans; Insulin; Insulin Resistance; Japan; Liver; Male; Middle Aged; Sodium-Glucose Transporter 2 Inhibitors; Thiophenes; Time Factors; Treatment Outcome | 2022 |
Quinine Effects on Gut and Pancreatic Hormones and Antropyloroduodenal Pressures in Humans-Role of Delivery Site and Sex.
Topics: Cholecystokinin; Double-Blind Method; Energy Intake; Female; Gastrointestinal Motility; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Male; Pancreatic Hormones; Peptide YY; Quinine | 2022 |
Effects of ileal glucose infusion on enteropancreatic hormone secretion in humans: relationship to glucose absorption.
Topics: 3-O-Methylglucose; Blood Glucose; C-Peptide; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Ileum; Insulin; Peptide Fragments | 2022 |
A phase 1b randomised controlled trial of a glucagon-like peptide-1 and glucagon receptor dual agonist IBI362 (LY3305677) in Chinese patients with type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Peptides; Receptors, Glucagon; Recombinant Fusion Proteins | 2022 |
Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis.
Topics: Adult; Arginine; Blood Glucose; Cystic Fibrosis; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Incretins; Insulin; Proinsulin | 2022 |
Postprandial Dynamics of Proglucagon Cleavage Products and Their Relation to Metabolic Health.
Topics: Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Proglucagon | 2022 |
Circulating levels of five proglucagon-derived peptides in response to intravenous or oral glucose or lipids and to a mixed-meal in subjects with normal weight, overweight, and obesity.
Topics: Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Lipids; Obesity; Overweight; Oxyntomodulin; Peptides; Proglucagon | 2022 |
No effect of multi-strain probiotic supplementation on metabolic and inflammatory markers and newborn body composition in pregnant women with obesity: Results from a randomized, double-blind placebo-controlled study.
Topics: Biomarkers; Body Composition; Double-Blind Method; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Infant, Newborn; Obesity; Pregnancy; Pregnant Women; Probiotics | 2023 |
1442 other study(ies) available for glucagon and glucagon-like peptide 1
| Article | Year |
|---|---|
The enteroinsular axis.
Topics: Animals; Digestive System Physiological Phenomena; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Islets of Langerhans; Peptide Fragments; Peptides; Rats | 1978 |
Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells.
Topics: Animals; Chloramphenicol O-Acetyltransferase; Cyclic AMP; Diabetes Mellitus, Type 2; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Mice; Pancreatic Neoplasms; Peptide Fragments; Peptides; Proinsulin; Promoter Regions, Genetic; RNA, Messenger; Tumor Cells, Cultured | 1992 |
Solubilization of active GLP-1 (7-36)amide receptors from RINm5F plasma membranes.
Topics: Animals; Cations; Detergents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Binding; Rats; Receptors, Cell Surface; Receptors, Glucagon; Solubility; Thionucleotides; Tumor Cells, Cultured | 1992 |
Alterations in proglucagon processing and inhibition of proglucagon gene expression in transgenic mice which contain a chimeric proglucagon-SV40 T antigen gene.
Topics: Animals; Antigens, Polyomavirus Transforming; Chromatography, High Pressure Liquid; Digestive System; Glucagon; Glucagon-Like Peptide 1; Insulin; Mice; Mice, Transgenic; Organ Specificity; Pancreas; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Protein Processing, Post-Translational; Rats; Recombinant Fusion Proteins; Reference Values; Simian virus 40 | 1992 |
Truncated glucagon-like peptide-1 interacts with exendin receptors on dispersed acini from guinea pig pancreas. Identification of a mammalian analogue of the reptilian peptide exendin-4.
Topics: Amino Acid Sequence; Animals; Cyclic AMP; Exenatide; Glucagon; Glucagon-Like Peptide 1; Guinea Pigs; Lizards; Male; Molecular Sequence Data; Pancreas; Peptide Fragments; Peptides; Protein Precursors; Receptors, Gastrointestinal Hormone; Venoms | 1992 |
Induction of glucose competence in pancreatic beta cells by glucagon-like peptide-1(7-37).
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Models, Biological; Peptide Fragments; Peptides; Potassium Channels; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1992 |
Antidiabetogenic effect of glucagon-like peptide-1 (7-36)amide in normal subjects and patients with diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Infusion Systems; Insulin Secretion; Male; Middle Aged; Obesity; Peptide Fragments; Peptides; Somatostatin | 1992 |
Pertussis toxin-sensitive and pertussis toxin-insensitive inhibition of parietal cell response to GLP-1 and histamine.
Topics: Adenylate Cyclase Toxin; Aminopyrine; Animals; Cyclic AMP; Dinoprostone; Drug Resistance; Glucagon; Glucagon-Like Peptide 1; Histamine; Osmolar Concentration; Parietal Cells, Gastric; Peptide Fragments; Pertussis Toxin; Protein Kinase Inhibitors; Protein Precursors; Somatostatin; Thionucleotides; Virulence Factors, Bordetella | 1992 |
Autoradiographic localization of receptors for glucagon-like peptide-1 (7-36) amide in rat brain.
Topics: Animals; Brain Chemistry; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Male; Neurotransmitter Agents; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Glucagon | 1992 |
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
Topics: Adenylate Cyclase Toxin; Animals; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Galanin; Gene Expression; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Mice; Models, Biological; Pancreatic Neoplasms; Peptide Fragments; Peptides; Pertussis Toxin; Proinsulin; RNA, Neoplasm; Transfection; Virulence Factors, Bordetella | 1992 |
Decrease in plasma GLP-1 immunoreactivity in starved rats.
Topics: Analysis of Variance; Animals; Body Weight; Chromatography, High Pressure Liquid; Fasting; Glucagon; Glucagon-Like Peptide 1; Ileum; Insulin; Male; Peptide Fragments; Proglucagon; Protein Precursors; Protein Processing, Post-Translational; Rats; Rats, Inbred Strains; Reference Values; RNA; Starvation; Time Factors | 1992 |
Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Clone Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptide Fragments; Peptides | 1992 |
Some peptide-like colocalizations in endocrine cells of the pyloric caeca and the intestine of Oncorhynchus mykiss (Teleostei).
Topics: Animals; Cecum; Cholecystokinin; Endocrine Glands; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; Intestinal Mucosa; Intestines; Neuropeptide Y; Pancreatic Polypeptide; Peptide Fragments; Peptide YY; Peptides; Protein Precursors; Trout | 1992 |
Discussing the role of glucagonlike peptide-I.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Peptide Fragments; Protein Precursors | 1992 |
Comparison of the insulinotropic activity of glucagon-superfamily peptides in rat pancreas perfusion.
Topics: Amino Acid Sequence; Animals; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Growth Hormone-Releasing Hormone; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Molecular Sequence Data; Peptide Fragments; Rats; Rats, Wistar; Sequence Homology, Amino Acid; Vasoactive Intestinal Peptide | 1992 |
Glucagon-like peptide-1 cells in the gastrointestinal tract and pancreas of rat, pig and man.
Topics: Animals; Digestive System; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Immunohistochemistry; Microscopy, Electron; Pancreas; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; Swine | 1992 |
Interaction of glucagon-like peptide-1(7-36) amide and gastric inhibitory polypeptide or cholecystokinin on insulin and glucagon secretion from the isolated perfused rat pancreas.
Topics: Animals; Drug Interactions; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Sincalide; Time Factors | 1992 |
The enteroinsular axis revisited. A novel role for an incretin.
Topics: Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Peptide Fragments; Peptides | 1992 |
Differences in glucagon-like peptide-1 and GIP responses following sucrose ingestion.
Topics: Adult; Blood Glucose; Cyclohexanols; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycoside Hydrolase Inhibitors; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Kinetics; Male; Peptide Fragments; Protein Precursors; Reference Values; Sucrose; Time Factors | 1992 |
Comparison of the effect of GIP and GLP-1 (7-36amide) on insulin release from rat pancreatic islets.
Topics: Animals; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains | 1992 |
[A case of hyperinsulinemia due to hypersecretion of incretin].
Topics: Aged; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Hyperinsulinism; Insulin; Insulin Secretion; Male; Peptide Fragments; Protein Precursors | 1992 |
Endocrine response to intragastric and intravenous glucose challenge in the denervated dog pancreas.
Topics: Animals; Blood Glucose; Denervation; Dogs; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Pancreas; Pancreas Transplantation; Pancreatic Polypeptide; Peptide Fragments; Transplantation, Autologous | 1992 |
Nutrient-independent increases in proglucagon and ornithine decarboxylase messenger RNAs after jejunoileal resection.
Topics: Adaptation, Physiological; Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Ileum; Jejunum; Male; Ornithine Decarboxylase; Peptide Fragments; Proglucagon; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 1992 |
Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes.
Topics: Animals; Calcium; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Gluconeogenesis; In Vitro Techniques; Liver; Male; Peptide Fragments; Peptides; Phosphorylase a; Rats; Rats, Inbred Strains; Tumor Cells, Cultured | 1991 |
Glucagonlike peptide-I-(7-36)-amide receptors only in islets of Langerhans. Autoradiographic survey of extracerebral tissues in rats.
Topics: Animals; Autoradiography; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Iodine Radioisotopes; Islets of Langerhans; Male; Peptide Fragments; Peptides; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Glucagon; Stomach | 1991 |
Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line.
Topics: Animals; Binding, Competitive; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Hormones; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Rats; Receptors, Cell Surface; Receptors, Glucagon; Secretory Rate; Somatostatin | 1991 |
Developmental patterns of glucagon-like peptide-1-(7-36) amide and peptide-YY in rat pancreas and gut.
Topics: Aging; Animals; Animals, Newborn; Chromatography, Gel; Fetus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Intestinal Mucosa; Intestines; Pancreas; Peptide Fragments; Peptide YY; Peptides; Radioimmunoassay; Rats; Rats, Inbred Strains; Somatostatin | 1991 |
Glucagonomas of transgenic mice express a wide range of general neuroendocrine markers and bioactive peptides.
Topics: Animals; Antigens, Polyomavirus Transforming; Biomarkers; Glucagon; Glucagon-Like Peptide 1; Glucagonoma; Immunohistochemistry; Insulin; Mice; Mice, Transgenic; Pancreatic Neoplasms; Pancreatic Polypeptide; Peptide Fragments; Proglucagon; Protein Precursors; Radioimmunoassay; Somatostatin | 1991 |
Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas.
Topics: Animals; Antibody Specificity; Chromatography, Gel; Chromatography, High Pressure Liquid; Epitopes; Glucagon; Glucagon-Like Peptide 1; Immune Sera; Intestinal Mucosa; Pancreas; Peptide Fragments; Protein Precursors; Protein Processing, Post-Translational; Radioimmunoassay; Rats | 1990 |
Interaction of glucagon-like peptide-1 (7-36)amide and cholecystokinin-8 in the endocrine and exocrine rat pancreas.
Topics: Amylases; Animals; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Islets of Langerhans; Male; Pancreas; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Sincalide | 1990 |
Priming effect of glucagon-like peptide-1 (7-36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Sincalide | 1991 |
[Recent advances in gastrointestinal hormones].
Topics: Amino Acid Sequence; Animals; Autonomic Nervous System; Cell Communication; Galanin; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Molecular Sequence Data; Neurotransmitter Agents; Peptide Fragments; Peptides; Protein Precursors; Protein Processing, Post-Translational | 1990 |
GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Biological Transport; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; In Vitro Techniques; Inositol Phosphates; Kinetics; Parietal Cells, Gastric; Peptide Fragments; Peptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1991 |
Effects of glucagon-like peptide 1 (7-36) amide and glucagon on amylin release from perfused rat pancreas.
Topics: Amyloid; Animals; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Homeostasis; Insulin; Islet Amyloid Polypeptide; Male; Pancreas; Peptide Fragments; Peptides; Perfusion; Radioimmunoassay; Rats; Rats, Inbred Strains | 1991 |
Hyperglycaemia but not hyperinsulinaemia prevents the secretion of glucagon-like peptide-1 (7-36 amide) stimulated by fat ingestion.
Topics: Adult; Analysis of Variance; Blood Glucose; Chromatography, Gel; Dietary Fats; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hyperglycemia; Injections, Intravenous; Insulin; Peptide Fragments; Peptides | 1991 |
Sensitivity of serum insulin concentrations to glucagon-like peptide 1 (7-36)amide in sheep.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Peptide Fragments; Protein Precursors; Sheep | 1991 |
GLP-1(7-36) amide stimulates insulin secretion in rat islets: studies on the mode of action.
Topics: Alkaloids; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Protein Kinase C; Rats; Rats, Inbred Strains; Staurosporine | 1991 |
The structure-function relationship of GLP-1 related peptides in the endocrine function of the canine pancreas.
Topics: Animals; Atropine; Dogs; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Peptides; Protein Precursors; Structure-Activity Relationship | 1991 |
Characterization of glucagon-like peptide-I(7-36)amide receptors of rat lung membranes by covalent cross-linking.
Topics: Animals; Cell Membrane; Cells, Cultured; Cross-Linking Reagents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Ligands; Lung; Molecular Weight; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Succinimides | 1991 |
Half-disappearance time of endogenous GLP-1 immunoreactivity in man.
Topics: Adult; Arginine; Chromatography, Gel; Glucagon; Glucagon-Like Peptide 1; Glucose; Half-Life; Humans; Peptide Fragments; Protein Precursors | 1991 |
GLP-1(7-36)amide-stimulated insulin secretion in rat islets is sodium-dependent.
Topics: Animals; Calcium; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Rubidium; Sodium | 1991 |
GLP-1 and GLP-1(7-36) amide: influences on basal and stimulated insulin and glucagon secretion in the mouse.
Topics: Animals; Blood Glucose; Carbachol; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Intestines; Mice; Mice, Inbred Strains; Pancreas; Peptide Fragments; Peptides; Protein Precursors; Reference Values; Sincalide | 1991 |
Emptying of the gastric substitute, glucagon-like peptide-1 (GLP-1), and reactive hypoglycemia after total gastrectomy.
Topics: Blood Glucose; Dumping Syndrome; Eating; Gastrectomy; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemia; Insulin; Peptide Fragments; Protein Precursors | 1991 |
Effect of the entero-pancreatic hormones, gastric inhibitory polypeptide and glucagon-like polypeptide-1(7-36) amide, on fatty acid synthesis in explants of rat adipose tissue.
Topics: Adipose Tissue; Animals; Culture Techniques; Fatty Acids; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Male; Neuropeptides; Peptide Fragments; Peptides; Rats | 1991 |
Effect of glucagon-like peptide-1 on gastric somatostatin and gastrin secretion in the rat.
Topics: Animals; Dose-Response Relationship, Drug; Female; Gastric Mucosa; Gastrins; Glucagon; Glucagon-Like Peptide 1; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; Somatostatin | 1990 |
Proglucagon products in plasma of noninsulin-dependent diabetics and nondiabetic controls in the fasting state and after oral glucose and intravenous arginine.
Topics: Administration, Oral; Adult; Aged; Arginine; Chromatography, Gel; Diabetes Mellitus, Type 2; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Infusions, Intravenous; Male; Middle Aged; Peptide Fragments; Proglucagon; Protein Precursors; Radioimmunoassay | 1991 |
Effects of truncated glucagon-like peptide-1 on the responses of starved sheep to glucose.
Topics: Animals; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Peptide Fragments; Protein Precursors; Sheep; Starvation; Urea | 1991 |
Renal catabolism of human glucagon-like peptides 1 and 2.
Topics: Animals; Chromatography, High Pressure Liquid; Glomerular Filtration Rate; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; In Vitro Techniques; Inulin; Iodine Radioisotopes; Kidney; Nephrectomy; Peptide Fragments; Peptides; Perfusion; Protein Precursors; Rats; Rats, Inbred Strains | 1990 |
Gut signals for islet hormone release.
Topics: Animals; Cholecystokinin; Digestive System Physiological Phenomena; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Islets of Langerhans; Peptide Fragments; Peptides; Protein Precursors; Rats | 1990 |
Reduced insulinotropic effects of glucagonlike peptide I-(7-36)-amide and gastric inhibitory polypeptide in isolated perfused diabetic rat pancreas.
Topics: Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Pancreas; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Streptozocin | 1990 |
Glucagon-like peptide-I analogs: effects on insulin secretion and adenosine 3',5'-monophosphate formation.
Topics: Animals; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Male; Pancreas; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains | 1990 |
Characterization of high-affinity receptors for truncated glucagon-like peptide-1 in rat gastric glands.
Topics: Animals; Cyclic AMP; Gastric Acid; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; Receptors, Cell Surface | 1990 |
Characterization of receptors for glucagon-like peptide-1(7-36)amide on rat lung membranes.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Kinetics; Lung; Male; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Glucagon | 1990 |
Metabolic response of teleost hepatocytes to glucagon-like peptide and glucagon.
Topics: Animals; Cyclic AMP; Dose-Response Relationship, Drug; Eels; Fishes; Glucagon; Glucagon-Like Peptide 1; Gluconeogenesis; In Vitro Techniques; Liver; Liver Glycogen; Peptide Fragments; Protein Precursors; Seasons; Stimulation, Chemical; Trout | 1990 |
Glucagon-like peptide-1(7-36)amide: characterization of the domain responsible for binding to its receptor on rat insulinoma RINm5F cells.
Topics: Animals; Binding Sites; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Tumor Cells, Cultured | 1990 |
Dexamethasone pretreatment of rat insulinoma cells decreases binding of glucagon-like peptide-1(7-36)amide.
Topics: Animals; Cyclic AMP; Dexamethasone; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucocorticoids; Insulinoma; Mifepristone; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Binding; Rats; Time Factors; Tumor Cells, Cultured | 1990 |
Glucagon-like peptide-1(7-37) does not stimulate either hepatic glycogenolysis or ketogenesis.
Topics: Animals; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glycogen; Ketones; Liver; Male; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains | 1990 |
Suppression of synthesis and release of glucagon by glucagon-like peptide-1 (7-36 amide) without affect on mRNA level in isolated rat islets.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger | 1990 |
Comparison of GLP-1 (7-36amide) and GIP on release of somatostatin-like immunoreactivity and insulin from the isolated rat pancreas.
Topics: Animals; Blood Glucose; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Pancreas; Peptide Fragments; Peptides; Perfusion; Rats | 1990 |
Carbachol priming increases glucose- and glucagon-like peptide-1 (7-36)amide-, but not arginine-induced insulin secretion from the isolated perfused rat pancreas.
Topics: Animals; Arginine; Blood Glucose; Carbachol; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Male; Pancreas; Peptide Fragments; Peptides; Perfusion; Rats; Stimulation, Chemical | 1990 |
Effects of truncated glucagon-like peptide-1 on pancreatic hormone release in normal conscious dogs.
Topics: Animals; Blood Glucose; Dogs; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Kinetics; Pancreatic Hormones; Peptide Fragments; Peptides | 1990 |
[Digestive tract hormones and pancreatic secretion].
Topics: Animals; Arginine; Blood Glucose; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Intestines; Mice; Pancreatic Hormones; Peptide Fragments; Peptides; Protein Precursors; Rats; Sincalide | 1990 |
Glucagon-like peptide-1 (7-36)-NH2: a physiological inhibitor of gastric acid secretion in man.
Topics: Adult; Depression, Chemical; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Male; Pentagastrin; Peptide Fragments; Peptides; Secretory Rate; Time Factors | 1990 |
Characterization of the receptor for glucagon-like peptide-1(7-36)amide on plasma membranes from rat insulinoma-derived cells by covalent cross-linking.
Topics: Adenoma, Islet Cell; Animals; Cell Line; Cell Membrane; Cross-Linking Reagents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1989 |
Signal transmission after GLP-1(7-36)amide binding in RINm5F cells.
Topics: Adenoma, Islet Cell; Animals; Calcium; Cell Line; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Membrane Potentials; Peptide Fragments; Peptides; Rats; Signal Transduction; Tumor Cells, Cultured | 1989 |
Internalization of glucagon-like peptide-1(7-36)amide in rat insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Chloroquine; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Temperature; Tumor Cells, Cultured | 1989 |
Comparison of the effects of glucagon-like peptide-1-(1-37) and -(7-37) and glucagon on islet hormone release from isolated perfused canine and rat pancreases.
Topics: Animals; Cell Separation; Dogs; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Islets of Langerhans; Male; Pancreas; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Somatostatin | 1989 |
Interaction of glucagon-like peptide-1(7-36)amide and somatostatin-14 in RINm5F cells and in the perfused rat pancreas.
Topics: Adenoma, Islet Cell; Animals; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulinoma; Male; Pancreas; Peptide Fragments; Peptides; Rats; Somatostatin; Tumor Cells, Cultured | 1989 |
Effects of glucagonlike peptide I-(7-36) on release of insulin, glucagon, and somatostatin by rat pancreatic islet cell monolayer cultures.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Somatostatin | 1989 |
Distribution and molecular forms of glucagon-like peptide in the dog.
Topics: Animals; Antibodies; Antibody Specificity; Brain Chemistry; Chromatography, Gel; Digestive System; Dogs; Glucagon; Glucagon-Like Peptide 1; Hypothalamus; Ileum; Pancreas; Peptide Fragments; Protein Precursors; Radioimmunoassay; Stomach; Tissue Distribution | 1989 |
Glucagonlike peptide I (7-37) actions on endocrine pancreas.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Peptides; Rats | 1989 |
Glucagonostatic and insulinotropic action of glucagonlike peptide I-(7-36)-amide.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Male; Pancreas; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains | 1989 |
Synergistic stimulatory effect of glucagon-like peptide-1 (7-36) amide and glucose-dependent insulin-releasing polypeptide on the endocrine rat pancreas.
Topics: Animals; Drug Synergism; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Stimulation, Chemical | 1989 |
Comparison of the effects of various C-terminal and N-terminal fragment peptides of glucagon-like peptide-1 on insulin and glucagon release from the isolated perfused rat pancreas.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histidine; Insulin; Insulin Secretion; Male; Pancreas; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1989 |
GLP-1 (glucagon-like peptide 1) and truncated GLP-1, fragments of human proglucagon, inhibit gastric acid secretion in humans.
Topics: Adult; Dose-Response Relationship, Drug; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Half-Life; Humans; Male; Middle Aged; Pancreatic Hormones; Pentagastrin; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Radioimmunoassay; Time Factors | 1989 |
Identification of glucagon-like peptide-1(7-36) amide in rat brain.
Topics: Animals; Brain Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Male; Peptide Fragments; Peptides; Radioimmunoassay; Rats; Rats, Inbred Strains | 1989 |
Characterization of glucagon-like peptide-1-(7-36)amide in the hypothalamus.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamus; Immunohistochemistry; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains | 1989 |
Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH).
Topics: Adenoma, Islet Cell; Animals; Binding, Competitive; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Insulinoma; Intestinal Mucosa; Intestines; Kinetics; Pancreatic Neoplasms; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1988 |
Receptors for glucagon-like peptide-1(7-36) amide on rat insulinoma-derived cells.
Topics: Adenoma, Islet Cell; Animals; Binding, Competitive; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Intestinal Mucosa; Jejunum; Pancreatic Neoplasms; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1988 |
Effect of truncated glucagon-like peptide 1 on cAMP in rat gastric glands and HGT-1 human gastric cancer cells.
Topics: Animals; Cyclic AMP; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Humans; Male; Peptides; Protein Precursors; Rats; Receptors, Cell Surface; Receptors, Glucagon; Stomach Neoplasms; Tumor Cells, Cultured | 1988 |
Identification and characterization of glucagon-like peptide-1 7-36 amide-binding sites in the rat brain and lung.
Topics: Animals; Binding, Competitive; Brain; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Kinetics; Lung; Organ Specificity; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1988 |
Effect of truncated glucagon-like peptide-1 [proglucagon-(78-107) amide] on endocrine secretion from pig pancreas, antrum, and nonantral stomach.
Topics: Animals; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Ileum; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Organ Specificity; Peptide Fragments; Protein Precursors; Pyloric Antrum; Somatostatin; Swine | 1988 |
Glucagon-like peptide-1 does not have a role in hepatic carbohydrate metabolism.
Topics: Animals; Cell Membrane; Cyclic AMP; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Kinetics; Liver; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon | 1985 |
Identification and localization of glucagon-like peptide-1 and its receptor in rat brain.
Topics: Animals; Brain Chemistry; Chromatography, Gel; Chromatography, High Pressure Liquid; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hypothalamus; Male; Medulla Oblongata; Peptides; Pituitary Gland; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Thalamus; Tissue Distribution | 1987 |
Effect of glucagon-like peptide-1 on insulin secretion.
Topics: Animals; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Male; Pancreas; Peptides; Perfusion; Rats; Rats, Inbred Strains | 1988 |
Absence of the "incretin" phenomenon in the autotransplanted human pancreas.
Topics: Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Middle Aged; Pancreas; Pancreas Transplantation; Peptide Fragments; Transplantation, Autologous | 1988 |
Glucagon-like peptide-1 (7-36 amide): a potent glucagonostatic and insulinotropic hormone.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Reference Values | 1988 |
Glucagon-like peptides activate hepatic gluconeogenesis.
Topics: Animals; Carbon Dioxide; Catfishes; Fishes; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Gluconeogenesis; In Vitro Techniques; Lactates; Liver; Peptides; Salmon; Trout | 1987 |
Isolation and characterisation of GLP-1 7-36 amide from rat intestine. Elevated levels in diabetic rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Colon; Diabetes Mellitus, Experimental; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Ileum; Intestinal Mucosa; Intestines; Mass Spectrometry; Molecular Weight; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
A large molecular form of glucagon-like peptide-1 (GLP-1) immunoreactivity is co-released with glucagon from pancreas by arginine in normal subjects.
Topics: Adult; Arginine; Blood Glucose; Chromatography, Gel; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Humans; Injections, Intravenous; Insulin; Pancreas; Peptides | 1987 |
Effects of intraduodenal nutrient infusion on insulin response to subsequent intravenous glucose in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Duodenum; Femoral Vein; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Infusions, Intravenous; Injections; Insulin; Insulin Secretion; Male; Peptide Fragments; Portal Vein; Rats; Rats, Inbred Strains | 1987 |
Effect of glucagon on secretion of glucagon-like peptide 1.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Male; Pancreas; Peptides; Rats; Rats, Inbred Strains | 1988 |
Trophic effect of glucagon-(1-21)-peptide on the isolated rat ileal mucosal cells.
Topics: Amino Acid Sequence; Animals; Cell Division; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Ileum; Intestinal Mucosa; Male; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Thymidine | 1988 |
Comparison of half-disappearance times, distribution volumes and metabolic clearance rates of exogenous glucagon-like peptide 1 and glucagon in rats.
Topics: Animals; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Infusions, Intravenous; Injections, Intravenous; Male; Metabolic Clearance Rate; Peptides; Rats; Rats, Inbred Strains | 1988 |
Pancreatic and intestinal processing of proglucagon in man.
Topics: Adult; Amino Acid Sequence; Chromatography, Gel; Chromatography, High Pressure Liquid; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Ileum; Intestine, Small; Pancreas; Pancreatic Hormones; Peptides; Proglucagon; Protein Precursors; Radioimmunoassay | 1987 |
Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas.
Topics: Animals; Arginine; Gastrin-Releasing Peptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucose; Histocytochemistry; Immunoenzyme Techniques; Intestine, Small; Pancreas; Peptides; Proglucagon; Protein Precursors; Swine | 1986 |
Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.
Topics: Animals; Genes; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Peptide Fragments; Peptides; Rats | 1987 |
Glucagon-like peptide-1 and the entero-insular axis in obese hyperglycaemic (ob/ob) mice.
Topics: Animals; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Insulin; Intestines; Islets of Langerhans; Mice; Mice, Obese; Peptides | 1987 |
Gastrointestinal peptides and insulin secretion.
Topics: Animals; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Liver; Neuropeptides; Obesity; Peptide Fragments | 1987 |
Release of glucagon-like peptide 1 immunoreactivity from the perfused rat pancreas.
Topics: Animals; Arginine; Chromatography, Gel; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Male; Pancreas; Peptides; Perfusion; Radioimmunoassay; Rats; Rats, Inbred Strains | 1987 |
Localization of glucagon-like peptide (GLP) immunoreactants in human gut and pancreas using light and electron microscopic immunocytochemistry.
Topics: Colon; Cytoplasmic Granules; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Gold; Histocytochemistry; Humans; Immunoenzyme Techniques; Immunologic Techniques; Intestines; Microscopy, Electron; Pancreas; Peptides; Proglucagon; Protein Precursors; Rectum | 1985 |
Human glucagon-like peptides 1 and 2 activate rat brain adenylate cyclase.
Topics: Adenylyl Cyclases; Brain; Dose-Response Relationship, Drug; Enzyme Activation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Peptides; Receptors, Cell Surface; Receptors, Glucagon | 1984 |
The effects of exercise on plasma insulin.
Topics: Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Liver; Muscles; Peptide Fragments; Peptides; Physical Education and Training; Physical Exertion; Receptors, Adrenergic, alpha | 1981 |
Preservation of incretin activity after removal of gastric inhibitory polypeptide (GIP) from rat gut extracts by immunoadsorption.
Topics: Animals; Antibodies; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Immunosorbent Techniques; Infusions, Parenteral; Insulin; Insulin Secretion; Intestinal Mucosa; Male; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains; Time Factors; Tissue Extracts | 1983 |
Partial purification of an insulin-releasing activity in human serum.
Topics: Animals; Biological Assay; Child; Chromatography, High Pressure Liquid; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Obesity; Peptide Fragments; Peptides; Rats; Rats, Inbred Strains | 1983 |
How glucagon-like is glucagon-like peptide-1?
Topics: Amino Acid Sequence; Animals; Blood Glucose; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Insulin; Peptides; Rabbits; Structure-Activity Relationship | 1984 |
[Gastric inhibitory polypeptide (GIP), incretin and gastrointestinal diseases].
Topics: Gastric Inhibitory Polypeptide; Gastrointestinal Diseases; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Peptide Fragments; Peptides; Radioimmunoassay | 1984 |
Gastric inhibitory polypeptide and insulin release in response to oral and intravenous glucose in coeliac disease.
Topics: Adult; Blood Glucose; Celiac Disease; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Peptide Fragments; Peptides | 1982 |
The broadening incretin concept.
Topics: Blood Glucose; Food; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Peptide Fragments; Peptides | 1980 |
The effects of glucagon-like peptide-I (GLP-I) on hormone secretion from isolated human pancreatic islets.
Topics: Culture Techniques; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Pancreatic Polypeptide; Peptide Fragments; Protein Precursors; Somatostatin | 1995 |
Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides.
Topics: Animals; Atropine; Bombesin; Cholinergic Agonists; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Ileum; In Vitro Techniques; Male; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Perfusion; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Secretory Rate; Stimulation, Chemical | 1995 |
Signal transduction of the GLP-1-receptor cloned from a human insulinoma.
Topics: Amino Acid Sequence; Animals; Blotting, Northern; Calcium; Cell Line; Cloning, Molecular; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulinoma; Molecular Sequence Data; Peptide Fragments; Rats; Receptors, Glucagon; Recombinant Proteins; RNA; Sequence Homology, Amino Acid; Signal Transduction; Transfection | 1994 |
Glucagon and glucagon-like peptide 1: selective receptor recognition via distinct peptide epitopes.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cell Membrane; Epitopes; Glucagon; Glucagon-Like Peptide 1; Kinetics; Liver; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Swine | 1994 |
Protein epitope mapping by mass spectrometry.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Epitope Mapping; Epitopes; Glucagon; Glucagon-Like Peptide 1; Mass Spectrometry; Melitten; Molecular Sequence Data; Peptide Fragments; Precipitin Tests; Protein Precursors | 1994 |
Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Ribonucleases; RNA, Messenger | 1995 |
Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Polyomavirus Transforming; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Intestinal Neoplasms; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Electron; Neoplasm Transplantation; Peptide Fragments; Proglucagon; Protein Precursors; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcium; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Ion Channels; Islets of Langerhans; Membrane Potentials; Peptide Fragments; Protein Precursors; Rats; Signal Transduction; Tumor Cells, Cultured | 1995 |
Human colon produces fully processed glucagon-like peptide-1 (7-36) amide.
Topics: Chromatography, High Pressure Liquid; Colon; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Proglucagon; Protein Precursors | 1995 |
Failure of GLP-1(7-36)amide to affect glycogenesis in rat skeletal muscle.
Topics: Animals; Biological Transport; Carbon Dioxide; Deoxyglucose; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glycogen; In Vitro Techniques; Insulin; Lactates; Male; Muscle, Skeletal; Peptide Fragments; Rats; Rats, Sprague-Dawley | 1995 |
Circulating gastrointestinal hormone changes in marathon running.
Topics: Adult; Chromogranin A; Female; Gastrins; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Neurokinin A; Pancreatic Hormones; Pancreatic Polypeptide; Peptide Fragments; Physical Endurance; Protein Precursors; Running; Secretin; Vasoactive Intestinal Peptide | 1995 |
Glucagon-like peptide-1 binding to rat hepatic membranes.
Topics: Animals; Autoradiography; Binding, Competitive; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Liver; Peptide Fragments; Peptides; Protein Binding; Rats; Rats, Wistar | 1995 |
[Mechanism of hyperinsulinemia in gastrectomized patients with oxyhyperglycemia: preliminary report].
Topics: Gastrectomy; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycosuria; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 1995 |
Glucagon-like peptide-1 affects gene transcription and messenger ribonucleic acid stability of components of the insulin secretory system in RIN 1046-38 cells.
Topics: Animals; Culture Media, Conditioned; Cycloheximide; Dactinomycin; Drug Stability; Drug Synergism; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 1; Hexokinase; Insulin; Insulin Secretion; Insulinoma; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Regulation of glucagon-like peptide-1-(7-36) amide, peptide YY, and neurotensin secretion by neurotransmitters and gut hormones in the isolated vascularly perfused rat ileum.
Topics: Animals; Bethanechol; Bombesin; Calcitonin Gene-Related Peptide; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Ileum; Isoproterenol; Male; Neurotensin; Neurotransmitter Agents; Parasympathomimetics; Peptide Fragments; Peptide YY; Peptides; Perfusion; Rats; Rats, Wistar; Tetrodotoxin | 1995 |
Stereospecific effects of fatty acids on proglucagon-derived peptide secretion in fetal rat intestinal cultures.
Topics: Animals; Cells, Cultured; Fatty Acids; Female; Fetus; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Peptide Fragments; Pregnancy; Proglucagon; Protein Kinase C; Protein Precursors; Rats; Rats, Wistar; Structure-Activity Relationship; Tetradecanoylphorbol Acetate | 1995 |
Effects of GLP-1 and 2,5-anhydro-D-mannitol on insulin secretion and plasma glucose in mice.
Topics: Animals; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Glycogen; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Liver; Mannitol; Mice; Muscle, Skeletal; Peptide Fragments; Protein Precursors | 1995 |
Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding, Competitive; Clone Cells; Cricetinae; Gastric Inhibitory Polypeptide; Gene Library; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulinoma; Kinetics; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Recombinant Proteins; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity; Swine; Transfection; Tumor Cells, Cultured | 1995 |
Stimulation of cloned human glucagon-like peptide 1 receptor expressed in HEK 293 cells induces cAMP-dependent activation of calcium-induced calcium release.
Topics: Acetylcholine; Calcium; Calcium Channel Blockers; Cell Line; Cloning, Molecular; Cyclic AMP; Embryo, Mammalian; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Ionomycin; Kidney; Peptide Fragments; Receptors, Glucagon; Recombinant Proteins; Ryanodine; Thionucleotides | 1995 |
Enteral enhancement of glucose disposition by both insulin-dependent and insulin-independent processes. A physiological role of glucagon-like peptide I.
Topics: Adult; Blood Glucose; Dietary Fats; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Kinetics; Male; Middle Aged; Peptide Fragments; Protein Precursors | 1995 |
Differential processing of proglucagon by the subtilisin-like prohormone convertases PC2 and PC3 to generate either glucagon or glucagon-like peptide.
Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Cell Line; Chlorocebus aethiops; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Kinetics; L Cells; Mice; Molecular Sequence Data; Peptide Biosynthesis; Peptide Fragments; Peptides; Proglucagon; Proprotein Convertase 2; Proprotein Convertases; Protein Precursors; Protein Processing, Post-Translational; Recombinant Proteins; Substrate Specificity; Subtilisins; Transfection | 1995 |
Insulinotropic actions of intravenous glucagon-like peptide-1 (GLP-1) [7-36 amide] in the fasting state in healthy subjects.
Topics: Adult; Analysis of Variance; C-Peptide; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Kinetics; Male; Peptide Fragments; Reference Values; Time Factors | 1995 |
Highly increased insulin secretion in a patient with postprandial hypoglycemia: role of glucagon-like peptide-1 (7-36) amide.
Topics: Adult; C-Peptide; Fasting; Food; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Insulin Secretion; Male; Peptide Fragments; Proinsulin | 1995 |
Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV.
Topics: Animals; Blood Physiological Phenomena; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Inbred F344; Rats, Wistar | 1995 |
Luminal glucagon-like peptide-1(7-36) amide-releasing factors in the isolated vascularly perfused rat colon.
Topics: Animals; Bile Acids and Salts; Colon; Deoxycholic Acid; Dose-Response Relationship, Drug; Fatty Acids, Volatile; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Male; Pectins; Peptide Fragments; Rats; Rats, Wistar | 1995 |
Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Enzyme-Linked Immunosorbent Assay; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Infusions, Intravenous; Injections, Subcutaneous; Male; Middle Aged; Peptide Fragments; Radioimmunoassay; Reference Values; Sensitivity and Specificity; Time Factors | 1995 |
Glucose-dependent action of glucagon-like peptide-1 (7-37) in vivo during short- or long-term administration.
Topics: Animals; Blood Glucose; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Infusion Pumps; Insulin; Kinetics; Male; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley | 1995 |
Effect of intestinal inhibitory peptides on vagally induced secretion from isolated perfused porcine pancreas.
Topics: Animals; Calcitonin Gene-Related Peptide; Electric Stimulation; Galanin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Neuropeptide Y; Oxyntomodulin; Pancreas; Peptide Fragments; Peptide YY; Peptides; Perfusion; Protein Precursors; Somatostatin; Swine; Vagus Nerve; Vasoactive Intestinal Peptide | 1993 |
Amylin alters the biological action of the incretin hormone GLP-1(7-36)amide.
Topics: Adenylyl Cyclases; Amyloid; Animals; Cell Line; Colforsin; Cyclic AMP; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Intolerance; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Models, Biological; Peptide Fragments; Peptides; Rats; Substance P | 1993 |
Insulin secretion and plasma levels of glucose-dependent insulinotropic peptide and glucagon-like peptide 1 [7-36 amide] after oral glucose in cirrhosis.
Topics: Adult; Blood Glucose; C-Peptide; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Insulin; Insulin Secretion; Liver Cirrhosis; Male; Middle Aged; Peptide Fragments | 1995 |
Ileal release of glucagon-like peptide-1 (GLP-1). Association with inhibition of gastric acid secretion in humans.
Topics: Adult; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Enteral Nutrition; Female; Gastric Acid; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Ileum; Intubation, Gastrointestinal; Male; Myoelectric Complex, Migrating; Peptide Fragments; Peptide YY; Peptides; Protein Precursors; Radioimmunoassay | 1995 |
Altered glucose dependence of glucagon-like peptide I(7-36)-induced insulin secretion from the Zucker (fa/fa) rat pancreas.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Obesity; Peptide Fragments; Perfusion; Rats; Rats, Zucker | 1995 |
Effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-I-(7-36) on insulin secretion.
Topics: Animals; Chromatography, High Pressure Liquid; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Male; Pancreas; Peptide Fragments; Rats; Rats, Wistar; Swine | 1995 |
Glucagon-like peptide-1 and glucose-dependent insulin-releasing polypeptide plasma levels in response to nutrients.
Topics: Adult; Amino Acids; Animals; Diet; Fats; Food; Galactose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Insulin; Insulin Secretion; Male; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar | 1995 |
Evidence that glucagon stimulates insulin secretion through its own receptor in rats.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Perfusion; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Time Factors; Venoms | 1995 |
A novel procedure for the preparation of biologically active recombinant peptides using a cyanylation reaction.
Topics: Amino Acid Sequence; Base Sequence; Escherichia coli; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Molecular Sequence Data; Peptide Biosynthesis; Peptide Fragments; Peptides; Plasmids; Recombinant Fusion Proteins | 1994 |
Comparative effects of GLP-1-(7-36) amide, oxyntomodulin and glucagon on rabbit gastric parietal cell function.
Topics: Aminopyrine; Animals; Blotting, Northern; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; Oxyntomodulin; Parietal Cells, Gastric; Peptide Fragments; Rabbits; RNA, Messenger; Somatostatin | 1995 |
Trout and chicken proglucagon: alternative splicing generates mRNA transcripts encoding glucagon-like peptide 2.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Chickens; DNA, Complementary; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Intestines; Molecular Sequence Data; Oncorhynchus mykiss; Pancreas; Peptides; Proglucagon; Protein Precursors; RNA, Messenger | 1995 |
Insulinotropic action of truncated glucagon-like peptide-1 in mice.
Topics: Animals; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Injections, Intravenous; Insulin; Mice; Mice, Inbred Strains; Pancreas; Peptide Fragments; Perfusion; Protein Precursors | 1995 |
Glucagon-like peptide-1 binding to rat skeletal muscle.
Topics: Adenylyl Cyclases; Animals; Binding, Competitive; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Muscle, Skeletal; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptor, Insulin; Receptors, Glucagon | 1995 |
Glucagon-like peptide I reduces postprandial glycemic excursions in IDDM.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Insulin; Male; Peptide Fragments; Protein Precursors | 1995 |
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Colforsin; Cyclic AMP; Cytoplasm; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Peptide Fragments; Ryanodine; Time Factors; Tumor Cells, Cultured | 1995 |
Structural characterization by affinity cross-linking of glucagon-like peptide-1(7-36)amide receptor in rat brain.
Topics: Animals; Brain Chemistry; Brain Stem; Cell Membrane; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Hypothalamus; Lung; Male; Peptide Fragments; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Glucagon | 1995 |
Use of 125I-[Y39]exendin-4 to characterize exendin receptors on dispersed pancreatic acini and gastric chief cells from guinea pig.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Cyclic AMP; Exenatide; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Guinea Pigs; Iodine Radioisotopes; Male; Molecular Sequence Data; Pancreas; Peptides; Receptors, Gastrointestinal Hormone; Structure-Activity Relationship; Tyrosine; Venoms | 1994 |
Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide.
Topics: Animals; Drug Interactions; Exenatide; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Insulin; Male; Peptide Fragments; Peptides; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Glucagon; Venoms | 1995 |
A novel insulin secretagogue is a phosphodiesterase inhibitor.
Topics: Animals; Calcium; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Obese; Pancreatic Neoplasms; Peptide Fragments; Phosphodiesterase Inhibitors; Piperazines; Protein Precursors; Tumor Cells, Cultured | 1995 |
[Secretion of peptide YY and truncated glucagon-like peptide 1 by isolated intestinal cells in rats].
Topics: Adult; Animals; Calcium-Transporting ATPases; Chromatography, Affinity; Glucagon; Glucagon-Like Peptide 1; Humans; Intestinal Mucosa; Ionomycin; Male; Peptide Fragments; Peptide YY; Peptides; Phorbols; Protein Precursors; Rats; Rats, Wistar; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1994 |
Glucagon-like peptide-1 (GLP-1): a piece of the incretin puzzle.
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Peptide Fragments; Peptides; Protein Precursors; Rodentia | 1995 |
Glucagon-like peptide-1 is a physiological incretin in rat.
Topics: Anesthesia; Animals; Arginine; Cells, Cultured; Consciousness; Eating; Fasting; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Infusions, Intravenous; Insulin; Insulin Secretion; Male; Pancreas; Peptide Fragments; Peptides; Protein Precursors; Radioligand Assay; Rats; Rats, Wistar; Receptors, Glucagon; Vasoactive Intestinal Peptide | 1995 |
Glucagon-like peptide-1 (GLP-1) molecular forms in human pancreatic endocrine tumors resemble those in intestine rather than pancreas.
Topics: Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagonoma; Humans; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Radioimmunoassay; Reference Values | 1994 |
Exendin-4 and exendin-(9-39)NH2: agonist and antagonist, respectively, at the rat parietal cell receptor for glucagon-like peptide-1-(7-36)NH2.
Topics: Aminopyrine; Animals; Binding, Competitive; Cell Membrane; Cross-Linking Reagents; Cyclic AMP; Exenatide; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; In Vitro Techniques; Lizards; Parietal Cells, Gastric; Peptide Fragments; Peptides; Rats; Rats, Wistar; Receptors, Glucagon; Venoms | 1994 |
Glucagon-like peptide-1 (7-36)amide and glucose-dependent insulinotropic polypeptide secretion in response to nutrient ingestion in man: acute post-prandial and 24-h secretion patterns.
Topics: Adult; Blood Glucose; Circadian Rhythm; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Eating; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Insulin; Lipid Metabolism; Nutritional Physiological Phenomena; Peptide Fragments; Radioimmunoassay; Time Factors | 1993 |
Glucagon-like peptide-1 modulates Ca2+ current but not K+ATP current in intact mouse pancreatic B-cells.
Topics: Adenosine Triphosphate; Animals; Calcium Channels; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Membrane Potentials; Mice; Mice, Inbred Strains; Peptide Fragments; Peptides; Potassium Channels; Protein Precursors | 1995 |
Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat adipose tissue.
Topics: Adipose Tissue; Animals; Culture Techniques; Dactinomycin; Enzyme Activation; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Lipoprotein Lipase; Male; Peptide Fragments; Rats; Rats, Wistar | 1995 |
Potent glycogenic effect of GLP-1(7-36)amide in rat skeletal muscle.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glycogen; Glycogen Synthase; Insulin; Lactates; Lactic Acid; Muscle, Skeletal; Neurotransmitter Agents; Peptide Fragments; Phosphorylase a; Rats; Rats, Wistar | 1994 |
Gastric inhibitory polypeptide and glucagon-like peptide-1(7-36) amide exert similar effects on somatostatin secretion but opposite effects on gastrin secretion from the rat stomach.
Topics: Animals; Gastric Inhibitory Polypeptide; Gastric Mucosa; Gastrins; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; In Vitro Techniques; Male; Peptide Fragments; Peptides; Rats; Rats, Wistar; Swine | 1994 |
Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo.
Topics: Chromatography, High Pressure Liquid; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Peptide Fragments; Protein Precursors | 1995 |
Glucagon-like peptide: a therapeutic glimmer.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protein Precursors | 1994 |
International Symposium on Glucagon-Like Peptide-1. Copenhagen, Denmark, May 17-19, 1993. Abstracts.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Protein Precursors | 1993 |
Glucose-dependent insulinotropic polypeptide stimulated insulin release from a tumor-derived beta-cell line (beta TC3).
Topics: Animals; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Iodine Radioisotopes; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Receptors, Cell Surface; Receptors, Gastrointestinal Hormone; Somatostatin; Swine; Tumor Cells, Cultured | 1993 |
Rat gastric somatostatin and gastrin release: interactions of exendin-4 and truncated glucagon-like peptide-1 (GLP-1) amide.
Topics: Animals; Exenatide; Gastric Juice; Gastrins; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Male; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Somatostatin; Venoms | 1994 |
Stable expression of the rat GLP-I receptor in CHO cells: activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin-4, and exendin(9-39).
Topics: Animals; CHO Cells; Cricetinae; Evaluation Studies as Topic; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Lizards; Neurotransmitter Agents; Oxyntomodulin; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Venoms | 1994 |
Glycosylation of the GLP-1 receptor is a prerequisite for regular receptor function.
Topics: Amidohydrolases; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glycosylation; Insulin; Insulin Secretion; Islets of Langerhans; Molecular Weight; Peptide Fragments; Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase; Receptors, Cell Surface; Receptors, Glucagon; Tumor Cells, Cultured; Tunicamycin | 1994 |
Rat parietal cell receptors for GLP-1-(7-36) amide: northern blot, cross-linking, and radioligand binding.
Topics: Aminopyrine; Animals; Blotting, Northern; Cell Separation; Cross-Linking Reagents; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Kinetics; Parietal Cells, Gastric; Peptide Fragments; Peptides; Radioligand Assay; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Glucagon; RNA, Messenger; Venoms | 1994 |
Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action.
Topics: 3T3 Cells; Adipocytes; Animals; Base Sequence; Blotting, Southern; DNA, Complementary; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Kidney; Mice; Molecular Sequence Data; Muscle, Skeletal; Peptide Fragments; Polymerase Chain Reaction; RNA, Messenger | 1994 |
Structure/activity characterization of glucagon-like peptide-1.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulinoma; Kinetics; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Receptors, Cell Surface; Receptors, Glucagon; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
FT-IR and near-infrared FT-Raman studies of the secondary structure of insulinotropin in the solid state: alpha-helix to beta-sheet conversion induced by phenol and/or by high shear force.
Topics: Amino Acid Sequence; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Circular Dichroism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humidity; Molecular Sequence Data; Peptide Fragments; Peptides; Phenols; Protein Structure, Secondary; Solubility; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman | 1994 |
Regulation of glucagon-like peptide-1-(7-36) amide secretion by intestinal neurotransmitters and hormones in the isolated vascularly perfused rat colon.
Topics: Animals; Colon; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Intestinal Mucosa; Male; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Perfusion; Rats; Rats, Wistar | 1994 |
Ligand-specificity of the rat GLP-I receptor recombinantly expressed in Chinese hamster ovary (CHO-) cells.
Topics: Animals; Blotting, Northern; CHO Cells; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Peptide Fragments; Protein Precursors; Rats; Receptors, Cell Surface; Receptors, Glucagon; Recombinant Proteins; Transfection | 1994 |
Glucose-dependent alterations of intracellular free calcium by glucagon-like peptide-1(7-36amide) in individual ob/ob mouse beta-cells.
Topics: Animals; Calcium; Cyclic AMP; Diabetes Mellitus, Type 2; Felodipine; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Islets of Langerhans; Mice; Mice, Inbred C57BL; Peptide Fragments | 1994 |
Incretin hormones regulate glucose-dependent insulin secretion in RIN 1046-38 cells: mechanisms of action.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Kinetics; Membrane Potentials; Pancreatic Neoplasms; Peptide Fragments; Potassium Chloride; Protein Precursors; Rats; Signal Transduction; Tumor Cells, Cultured | 1994 |
The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects.
Topics: Administration, Oral; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Drug Synergism; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Injections, Intravenous; Insulin; Male; Peptide Fragments; Peptides | 1994 |
Spermine-induced precocious intestinal maturation in suckling rats: possible involvement of glucocorticoids.
Topics: Administration, Oral; Adrenocorticotropic Hormone; Animals; Animals, Suckling; Cholecystokinin; Corticosterone; Disaccharidases; Gastrins; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Intestines; Peptides; Rats; Rats, Wistar; Secretin; Spermine; Stimulation, Chemical | 1994 |
Glucagon-like peptide 1: a potent glycogenic hormone.
Topics: Animals; Cells, Cultured; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycogen; Glycogen Synthase; Liver; Peptides; Phosphorylases; Rats; Rats, Wistar | 1994 |
Glucagon-like peptide 1 immunoreactivity in gastroentero-pancreatic endocrine tumors: a light- and electron-microscopic study.
Topics: Adolescent; Adult; Aged; Endocrine Gland Neoplasms; Female; Gastrointestinal Neoplasms; Glucagon; Glucagon-Like Peptide 1; Humans; Immunohistochemistry; Male; Microscopy, Immunoelectron; Middle Aged; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Precursors | 1994 |
Secretion of glucagon-like peptide-1 and reactive hypoglycemia after partial gastrectomy.
Topics: Administration, Oral; Adult; Blood Glucose; C-Peptide; Chromatography, Gel; Data Interpretation, Statistical; Female; Gastrectomy; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemia; Insulin; Insulin Secretion; Male; Middle Aged; Peptide Fragments; Protein Precursors; Radioimmunoassay | 1994 |
Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum.
Topics: Amino Acid Sequence; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Male; Models, Biological; Molecular Sequence Data; Peptide Fragments; Peptide PHI; Substrate Specificity | 1993 |
Glucagon-like peptide-1-(7-36) amide, oxyntomodulin, and glucagon interact with a common receptor in a somatostatin-secreting cell line.
Topics: Animals; Binding, Competitive; Blotting, Northern; Cell Line; Cell Membrane; Cricetinae; Cross-Linking Reagents; Cyclic AMP; Fibroblasts; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Oxyntomodulin; Peptide Fragments; Receptors, Cell Surface; Receptors, Glucagon; Somatostatin; Transfection | 1993 |
Effects of glucagon-like peptide-1(7-36)amide on the concentrations of insulin and glucose in sheep.
Topics: Animals; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Male; Peptides; Sheep | 1993 |
Stimulation of truncated glucagon-like peptide-1 release from the isolated perfused canine ileum by glucose absorption.
Topics: Animals; Deoxyglucose; Dogs; Glucagon; Glucagon-Like Peptide 1; Glucose; Ileum; In Vitro Techniques; Intestinal Absorption; Peptide Fragments; Protein Precursors; Stimulation, Chemical; Sucrose | 1994 |
Detection of the human glucagon-like peptide 1(7-36) amide receptor on insulinoma-derived cell membranes.
Topics: Animals; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Rats; Receptors, Cell Surface; Receptors, Glucagon; Tumor Cells, Cultured | 1994 |
Renal catabolism of truncated glucagon-like peptide 1.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Half-Life; Kidney; Kidney Tubules; Ligation; Male; Metabolic Clearance Rate; Nephrectomy; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Ureter | 1993 |
Structure-activity studies of glucagon-like peptide-1.
Topics: Adenylyl Cyclases; Alanine; Amino Acid Sequence; Animals; Binding, Competitive; Cell Line; Cell Membrane; Circular Dichroism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Kinetics; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Conformation; Protein Precursors; Receptors, Cell Surface; Receptors, Glucagon; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1994 |
Tissue and plasma concentrations of amidated and glycine-extended glucagon-like peptide I in humans.
Topics: Adult; Chromatography, Gel; Eating; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Immunohistochemistry; Intestine, Small; Male; Middle Aged; Pancreas; Peptide Fragments; Proglucagon; Protein Precursors; Protein Processing, Post-Translational | 1994 |
Structure-activity relationships of glucagon-like peptide-1(7-36)amide: insulinotropic activities in perfused rat pancreases, and receptor binding and cyclic AMP production in RINm5F cells.
Topics: Animals; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Insulinoma; Male; Pancreas; Peptide Fragments; Perfusion; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Glucagon; Stimulation, Chemical; Structure-Activity Relationship | 1994 |
Structure of glucagon-like peptide (7-36) amide in a dodecylphosphocholine micelle as determined by 2D NMR.
Topics: Amides; Amino Acid Sequence; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Kinetics; Magnetic Resonance Spectroscopy; Micelles; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Phosphorylcholine; Protein Structure, Secondary | 1994 |
Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line.
Topics: Calcium; Carbachol; Cell Line; Colforsin; Cyclic AMP; Endocrine Glands; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Intestines; Kinetics; Muscarinic Antagonists; N-Methylscopolamine; Parasympathomimetics; Peptide Fragments; Protein Precursors; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate | 1994 |
Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse.
Topics: Aging; Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Brain; Conserved Sequence; DNA, Complementary; Female; Fetus; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Mice; Molecular Sequence Data; Organ Specificity; Peptide Fragments; Polymerase Chain Reaction; Pregnancy; Protein Precursors; Rats; Receptors, Glucagon; RNA, Messenger; Sequence Analysis | 1994 |
Proglucagon is processed to glucagon by prohormone convertase PC2 in alpha TC1-6 cells.
Topics: Animals; Cell Line; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Islets of Langerhans; Peptide Fragments; Peptides; Proglucagon; Proprotein Convertase 2; Protein Precursors; Protein Processing, Post-Translational; Rats; Subtilisins | 1994 |
Changes in arterial blood pressure and heart rate induced by glucagon-like peptide-1-(7-36) amide in rats.
Topics: Animals; Blood Pressure; Catecholamines; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Heart Rate; Male; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Reserpine | 1994 |
Glucagon-like peptide 1 enhances glucose tolerance both by stimulation of insulin release and by increasing insulin-independent glucose disposal.
Topics: Adult; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Infusions, Intravenous; Insulin; Male; Middle Aged; Peptide Fragments | 1994 |
Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines.
Topics: Animals; Calcium; Cells, Cultured; Cloning, Molecular; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Inositol Phosphates; Islets of Langerhans; Kinetics; Peptide Fragments; Protein Precursors; Rats; Receptors, Cell Surface; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured | 1994 |
Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Aminopyrine; Animals; Cell Membrane; Cell Separation; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; GTP-Binding Proteins; Histamine; Kinetics; Molecular Weight; Parietal Cells, Gastric; Peptide Fragments; Rats; Rats, Wistar | 1994 |
Cloning and functional expression of a human glucagon-like peptide-1 receptor.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Receptors, Cell Surface; Receptors, Glucagon; Recombinant Proteins; Sequence Homology, Amino Acid; Transfection | 1993 |
GLP-1 stimulates secretion of macromolecules from airways and relaxes pulmonary artery.
Topics: Animals; Autoradiography; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Macromolecular Substances; Male; Mucus; Peptide Fragments; Protein Precursors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Trachea; Vasodilation | 1993 |
Structure and biological activity of glucagon and glucagon-like peptide from a primitive bony fish, the bowfin (Amia calva).
Topics: Amino Acid Sequence; Animals; Fishes; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycogen; Humans; Liver; Molecular Sequence Data; Pancreas; Peptide Fragments; Peptides; Sequence Homology, Amino Acid | 1993 |
Presence of glucagon and glucagon-like peptide-1-(7-36)amide receptors in solubilized membranes of human adipose tissue.
Topics: Adipose Tissue; Aged; Cell Membrane; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Male; Middle Aged; Peptide Fragments; Receptors, Cell Surface; Receptors, Glucagon | 1993 |
Effects of glucagon like peptide-1(7-36) amide on the cytoplasmic Ca(2+)-concentration in rat islet cells.
Topics: Animals; Calcium; Cytoplasm; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Spectrometry, Fluorescence | 1993 |
Effect of glucagon-like peptide-1 (proglucagon 78-107amide) on hepatic glucose production in healthy man.
Topics: Adult; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Liver; Male; Peptide Fragments; Protein Precursors; Radioimmunoassay | 1994 |
Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop.
Topics: Animals; Corn Oil; Duodenum; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Ileum; Infusions, Intravenous; Intestinal Secretions; Kinetics; Male; Peptide Fragments; Peptides; Rats; Rats, Wistar | 1993 |
Postprandial release of glucagon-like peptide-1, pancreatic glucagon, and insulin after esophageal resection.
Topics: Blood Glucose; Eating; Esophageal Neoplasms; Esophagoplasty; Esophagus; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Pancreas; Peptide Fragments; Protein Precursors; Stomach | 1993 |
Preserved incretin effect in type 1 diabetic patients with end-stage nephropathy treated by combined heterotopic pancreas and kidney transplantation.
Topics: Adult; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Pancreas Transplantation; Peptide Fragments; Protein Precursors; Radioimmunoassay; Reference Values; Transplantation, Heterotopic | 1993 |
Glucose dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36)amide: effects on lipoprotein lipase activity.
Topics: Adipose Tissue; Animals; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Lipoprotein Lipase; Peptide Fragments; Rats | 1993 |
Presence and characterization of glucagon-like peptide-1(7-36) amide receptors in solubilized membranes of rat adipose tissue.
Topics: Adipose Tissue; Animals; Binding, Competitive; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Kinetics; Male; Peptide Fragments; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Glucagon; Solubility; Temperature | 1993 |
The role of the free cytosolic calcium level in beta-cell signal transduction by gastric inhibitory polypeptide and glucagon-like peptide I(7-37).
Topics: Animals; Calcium; Cricetinae; Cyclic AMP; Cytosol; Egtazic Acid; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Islets of Langerhans; Nimodipine; Peptide Fragments; Peptides; Phosphatidylinositols; Signal Transduction; Tumor Cells, Cultured | 1993 |
Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37).
Topics: Animals; Cells, Cultured; Cyclic AMP; Drug Synergism; Electric Conductivity; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glyburide; Islets of Langerhans; Male; Membrane Potentials; Peptide Fragments; Peptides; Rats; Thionucleotides | 1993 |
Amino-terminal parathyroid hormone-related protein: specific binding and cytosolic calcium responses in rat insulinoma cells.
Topics: Animals; Binding Sites; Calcium; Cell Membrane; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glyburide; Insulinoma; Kinetics; Pancreatic Neoplasms; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Peptide Fragments; Peptides; Proteins; Rats; Rats, Inbred WF; Tumor Cells, Cultured | 1993 |
Solubilization of active receptors for glucagon-like peptide-1(7-36)amide from rat lung membranes.
Topics: Animals; Cations; Cell Membrane; Cross-Linking Reagents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Guanine Nucleotides; Hydrogen-Ion Concentration; Lung; Male; Peptide Fragments; Rats; Receptors, Cell Surface; Receptors, Glucagon; Solubility | 1993 |
Possible role of the adrenergic mechanism in gastric inhibitory polypeptide- and glucagon-like peptide-1 (7-36) amide-induced insulin release in the rat.
Topics: Animals; Blood Glucose; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Male; Peptide Fragments; Propranolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta | 1993 |
[Isolation and sequencing of cDNA of the GLP-I receptor].
Topics: Animals; Base Sequence; Cloning, Molecular; DNA; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1993 |
Functional expression of the rat glucagon-like peptide-I receptor, evidence for coupling to both adenylyl cyclase and phospholipase-C.
Topics: Adenylyl Cyclases; Animals; Calcium; Cell Line; Chlorocebus aethiops; Cyclic AMP; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Kidney; Peptide Fragments; Peptides; Phosphatidylinositols; Rats; Receptors, Cell Surface; Receptors, Glucagon; RNA, Messenger; Type C Phospholipases | 1993 |
Protein kinase C inhibits cyclic adenosine monophosphate generation by histamine and truncated glucagon like peptide 1 in the human gastric cancer cell line HGT-1.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Alkaloids; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Histamine; Humans; Peptide Fragments; Pertussis Toxin; Protein Kinase C; Protein Precursors; Receptors, Gastrointestinal Hormone; Receptors, Histamine H2; Staurosporine; Stimulation, Chemical; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1993 |
Pertussis toxin-sensitive inhibition of glucagon-like peptide 1-stimulated acid production by epidermal growth factor and transforming growth factor alpha in rat parietal cells.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Aminopyrine; Animals; Cyclic AMP; Epidermal Growth Factor; Female; Gastric Acid; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Peptide Fragments; Pertussis Toxin; Protein Precursors; Rats; Rats, Wistar; Transforming Growth Factor alpha; Virulence Factors, Bordetella | 1993 |
Neuropeptide Y expression and regulation in a differentiated rat insulin-secreting cell line.
Topics: Adenylyl Cyclases; Animals; Cell Differentiation; Clonidine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Protein Kinase C; Rats; Receptors, Neuropeptide Y; Tumor Cells, Cultured | 1993 |
Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting beta-cells.
Topics: Animals; Binding, Competitive; Cell Line; Cell Membrane; Cyclic AMP; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Kinetics; Lizards; Lung; Pancreatic Neoplasms; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Tumor Cells, Cultured; Venoms | 1993 |
Binding specificity and signal transduction of receptors for glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide on RINm5F insulinoma cells.
Topics: Animals; Binding Sites; Binding, Competitive; Cell Line; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Islets of Langerhans; Peptide Fragments; Rats; Receptors, Cell Surface; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Signal Transduction | 1993 |
Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islets of Langerhans; Nitrendipine; Osmolar Concentration; Peptide Fragments; Rats | 1993 |
Primary structures of glucagon and glucagon-like peptide isolated from the intestine of the parasitic phase lamprey Petromyzon marinus.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Humans; Intestines; Lampreys; Molecular Sequence Data; Peptides; Sequence Analysis; Sequence Homology, Amino Acid | 1993 |
Localization of amidating enzymes (PAM) in rat gastrointestinal tract.
Topics: Animals; Colon; Endocrine Glands; Glucagon; Glucagon-Like Peptide 1; Immunoenzyme Techniques; In Situ Hybridization; Intestine, Small; Mixed Function Oxygenases; Multienzyme Complexes; Nerve Fibers; Neurons; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Stomach | 1993 |
Glucagon-like peptide-I-(7-37) suppresses hyperglycemia in rats.
Topics: Administration, Oral; Animals; Blood Glucose; Dose-Response Relationship, Drug; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hyperglycemia; Insulin; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Reference Values | 1993 |
Truncated GLP-1 (proglucagon 78-107-amide) inhibits gastric and pancreatic functions in man.
Topics: Adult; Depression, Chemical; Female; Gastric Acid; Gastric Emptying; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Lipase; Male; Pancreas; Peptide Fragments; Protein Precursors; Random Allocation; Reference Values; Time Factors; Trypsin | 1993 |
Pancreas and gut hormone responses to oral glucose and intravenous glucagon in cystic fibrosis patients with normal, impaired, and diabetic glucose tolerance.
Topics: Administration, Oral; Adult; C-Peptide; Cystic Fibrosis; Diabetes Complications; Diabetes Mellitus; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Hormones; Humans; Injections, Intravenous; Insulin; Intestinal Mucosa; Intestines; Male; Middle Aged; Pancreas; Pancreatic Polypeptide; Peptide Fragments; Proinsulin; Protein Precursors; Time Factors | 1993 |
Biological effects and metabolic rates of glucagonlike peptide-1 7-36 amide and glucagonlike peptide-1 7-37 in healthy subjects are indistinguishable.
Topics: Adult; Blood Glucose; C-Peptide; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Male; Peptide Fragments; Structure-Activity Relationship; Time Factors | 1993 |
Influence of glucagon-like peptide-1 on beta cell responsiveness.
Topics: Animals; Carbachol; Cholecystokinin; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mannoheptulose; Peptide Fragments; Phosphorylation; Protein Precursors; Rats; Rats, Sprague-Dawley | 1993 |
Glucose-dependency of the insulin stimulatory effect of glucagon-like peptide-1 (7-36) amide on the rat pancreas.
Topics: Amides; Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas; Peptide Fragments; Perfusion; Radioimmunoassay; Rats; Rats, Wistar | 1993 |
Constitution of a biphasic insulin response to glucose in human fetal pancreatic beta-cells with glucagon-like peptide 1.
Topics: Adult; Culture Techniques; Cyclic AMP; Fetus; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors | 1995 |
A role for glucagon-like peptide-1 in the central regulation of feeding.
Topics: Animals; Cerebral Ventricles; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intraventricular; Male; Neuropeptide Y; Peptide Fragments; Proto-Oncogene Proteins c-fos; Rats; Satiation | 1996 |
Glycemic control mechanisms after canine islet autografting.
Topics: Animals; Blood Glucose; Dogs; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans Transplantation; Pancreatectomy; Peptide Fragments; Transplantation, Autologous | 1995 |
Dose-responses for the slowing of gastric emptying in a rodent model by glucagon-like peptide (7-36) NH2, amylin, cholecystokinin, and other possible regulators of nutrient uptake.
Topics: Amino Acids; Amyloid; Animals; Cholecystokinin; Dose-Response Relationship, Drug; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Gels; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islet Amyloid Polypeptide; Male; Pancreatic Polypeptide; Peptide Fragments; Phenolsulfonphthalein; Rats; Rats, Sprague-Dawley | 1996 |
Expression and functional activity of glucagon, glucagon-like peptide I, and glucose-dependent insulinotropic peptide receptors in rat pancreatic islet cells.
Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Gastric Inhibitory Polypeptide; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Receptors, Pancreatic Hormone; RNA, Messenger; Signal Transduction | 1996 |
Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons.
Topics: Animals; Antibodies, Monoclonal; Blood Glucose; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Insulin; Male; Papio; Peptide Fragments; Receptors, Glucagon; Xylose | 1996 |
Mechanism of impaired glucose-potentiated insulin secretion in diabetic 90% pancreatectomy rats. Study using glucagonlike peptide-1 (7-37).
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Synergism; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Organ Size; Pancreas; Pancreatectomy; Peptide Fragments; Peptides; Proinsulin; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors | 1996 |
Gastric emptying and release of incretin hormones after glucose ingestion in humans.
Topics: Adult; Blood Glucose; C-Peptide; Duodenum; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastric Mucosa; Gastrointestinal Hormones; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Insulin; Insulin Secretion; Male; Peptide Fragments | 1996 |
Comparison of sandwich enzyme-linked immunoadsorbent assay and radioimmunoassay for determination of exogenous glucagon-like peptide-1(7-36)amide in plasma.
Topics: Amino Acid Sequence; Animals; Antibodies; Cats; Chromatography, High Pressure Liquid; Dogs; Enzyme-Linked Immunosorbent Assay; Epitopes; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Molecular Sequence Data; Neurotransmitter Agents; Peptide Fragments; Rabbits; Radioimmunoassay; Rats; Reference Values; Sensitivity and Specificity; Sequence Homology, Amino Acid; Swine; Swine, Miniature | 1995 |
Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites.
Topics: Animals; Autoradiography; Binding Sites; Brain; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Kinetics; Male; Peptide Fragments; Peptides; Radioligand Assay; Rats; Rats, Wistar; Venoms | 1995 |
GIP and GLP-1(7-36)amide secretion in response to intraduodenal infusions of nutrients in pigs.
Topics: Analysis of Variance; Animals; Blood Glucose; Dietary Fats; Duodenum; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Peptide Fragments; Radioimmunoassay; Sodium Chloride; Swine; Triglycerides | 1995 |
Precipitation of insulinotropin in the presence of protamine: effect of phenol and zinc on the isophane ratio and the insulinotropin concentration in the supernatant.
Topics: Animals; Chemical Precipitation; Chromatography, High Pressure Liquid; Circular Dichroism; Drug Compounding; Evaluation Studies as Topic; Excipients; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hydrogen-Ion Concentration; Peptide Fragments; Peptides; Phenol; Phenols; Protamines; Technology, Pharmaceutical; Zinc | 1995 |
Intra-islet regulation of hormone secretion by glucagon-like peptide-1-(7--36) amide.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Hormones; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Somatostatin | 1995 |
PYY and GLP-1 contribute to feedback inhibition from the canine ileum and colon.
Topics: Animal Nutritional Physiological Phenomena; Animals; Colon; Dogs; Feedback; Female; Gastrointestinal Hormones; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Ileum; Injections, Intravenous; Intestine, Small; Myoelectric Complex, Migrating; Neurotensin; Peptide Fragments; Peptide YY; Peptides; Protein Precursors | 1995 |
Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7-36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptides.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Kinetics; Molecular Sequence Data; Neprilysin; Peptide Fragments; Protein Processing, Post-Translational; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 1995 |
Effects of cholecystokinin and glucagon-like peptide 1 on the secretion of pancreatic polypeptide in mice.
Topics: Animals; Benzodiazepinones; Blood Glucose; Devazepide; Female; Glucagon; Glucagon-Like Peptide 1; Hormone Antagonists; Insulin; Mice; Mice, Inbred Strains; Neurotransmitter Agents; Pancreatic Polypeptide; Peptide Fragments; Protein Precursors; Receptors, Cholecystokinin; Sincalide | 1995 |
Glucagon-like peptide 1 (7-36 amide) secretion in response to luminal sucrose from the upper and lower gut. A study using alpha-glucosidase inhibition (acarbose).
Topics: Acarbose; Adult; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Humans; Intestine, Small; Male; Peptide Fragments; Protein Precursors; Radioimmunoassay; Sucrose; Trisaccharides | 1995 |
Identification of specific binding sites for glucagon-like peptide-1 on the posterior lobe of the rat pituitary.
Topics: Animals; Autoradiography; Binding Sites; Binding, Competitive; Exenatide; Glucagon; Glucagon-Like Peptide 1; Iodine Radioisotopes; Lizards; Male; Peptide Fragments; Peptides; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Wistar; Vasoactive Intestinal Peptide; Venoms | 1995 |
Response of truncated glucagon-like peptide-1 and gastric inhibitory polypeptide to glucose ingestion in non-insulin dependent diabetes mellitus. Effect of sulfonylurea therapy.
Topics: Administration, Oral; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Male; Peptide Fragments; Protein Precursors; Sulfonylurea Compounds | 1995 |
Interaction of glucagon-like peptide-I (GLP-I) and galanin in insulin (beta TC-1)- and somatostatin (RIN T3)-secreting cells and evidence that both peptides have no receptors on glucagon (INR1G9)-secreting cells.
Topics: Animals; Cell Line; Drug Interactions; Galanin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Receptors, Galanin; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; RNA, Messenger; Somatostatin | 1995 |
The application of crystal soaking technique to study the effect of zinc and cresol on insulinotropin crystals grown from a saline solution.
Topics: Amino Acid Sequence; Calorimetry, Differential Scanning; Chemical Phenomena; Chemistry, Physical; Cresols; Crystallization; Crystallography, X-Ray; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hydrogen-Ion Concentration; Injections, Subcutaneous; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptide Fragments; Peptides; Photomicrography; Sodium Chloride; Solubility; Zinc | 1995 |
Glucagon-like peptide-1 stimulates insulin secretion but not phosphoinositide hydrolysis from islets desensitized by prior exposure to high glucose or the muscarinic agonist carbachol.
Topics: Animals; Carbachol; Glucagon; Glucagon-Like Peptide 1; Glucose; Hydrolysis; Insulin; Insulin Secretion; Islets of Langerhans; Male; Muscarinic Agonists; Peptide Fragments; Phosphatidylinositols; Protein Precursors; Rats; Rats, Sprague-Dawley | 1996 |
Effects of fasting, refeeding, and intraluminal triglyceride on proglucagon expression in jejunum and ileum.
Topics: Animals; Blotting, Northern; Eating; Fasting; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Ileum; In Situ Hybridization; Jejunum; Male; Peptide Fragments; Proglucagon; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Regression Analysis; RNA, Messenger; RNA, Ribosomal, 28S; Triglycerides | 1996 |
Comparison of the glucose dependency of glucagon-like peptide-1 (7-37) and glyburide in vitro and in vivo.
Topics: Animals; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley | 1996 |
The third cytoplasmic domain of the GLP-1[7-36 amide] receptor is required for coupling to the adenylyl cyclase system.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Protein Conformation; Rats; Receptors, Glucagon; Structure-Activity Relationship | 1996 |
Role of glutamate in regulating hypothalamic proglucagon-derived peptide secretion in vitro.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Cells, Cultured; Female; Glucagon; Glucagon-Like Peptide 1; Glutamic Acid; Hypothalamus; Peptide Fragments; Pregnancy; Protein Precursors; Quisqualic Acid; Rats | 1995 |
Potentiation of glucagon-like peptide 1 insulinotropic action by succinic acid dimethyl ester.
Topics: Animals; Drug Synergism; Female; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Perfusion; Protein Precursors; Rats; Rats, Wistar; Succinates | 1996 |
The effect of glucagon-like peptide I (GLP-I) on glucose elimination in healthy subjects depends on the pancreatic glucoregulatory hormones.
Topics: Adult; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Infusions, Intravenous; Insulin; Kinetics; Male; Peptide Fragments; Protein Precursors; Reference Values; Somatostatin; Time Factors | 1996 |
Release of glucagon-like peptide 1 (GLP-1 [7-36 amide]), gastric inhibitory polypeptide (GIP) and insulin in response to oral glucose after upper and lower intestinal resections.
Topics: Adult; Aged; C-Peptide; Colectomy; Crohn Disease; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Insulin; Intestine, Large; Intestine, Small; Male; Middle Aged; Peptide Fragments; Postoperative Complications | 1996 |
Effects of somatostatin-28 on plasma glucose-dependent insulinotropic polypeptide and serum insulin concentrations.
Topics: Animals; Blood Glucose; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Infusions, Intravenous; Insulin; Insulin Secretion; Peptide Fragments; Sheep; Somatostatin; Somatostatin-28 | 1995 |
Glucagon-like peptide-1(7-36)amide induces the release of aspartic acid and glutamine by the ventromedial hypothalamus of the conscious rat.
Topics: Animals; Aspartic Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glutamine; Hypothalamus, Middle; Male; Microdialysis; Neurotransmitter Agents; Peptide Fragments; Rats; Rats, Wistar | 1995 |
Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Animals; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Glucose; Insulin; Male; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Rats | 1996 |
Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth.
Topics: Adaptation, Physiological; Animals; Blotting, Northern; Eflornithine; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hyperplasia; Ileum; Intestinal Mucosa; Jejunum; Male; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Peptide Fragments; Proglucagon; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1996 |
Impaired cyclic AMP response to stimuli in glucose-desensitized rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Drug Tolerance; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 1995 |
Initiation of insulin secretion in glucose-free medium by activin A.
Topics: Activins; Animals; Calcium; Culture Media; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Inhibins; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar | 1995 |
Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling.
Topics: Adenylyl Cyclases; Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Calcium; Cell Line; Cell Membrane; Chlorocebus aethiops; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Kidney; Kinetics; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Point Mutation; Protein Precursors; Protein Structure, Secondary; Rats; Receptors, Glucagon; Recombinant Proteins; Signal Transduction; Transfection | 1996 |
The effect of some gastrointestinal peptides on pentagastrin-stimulated acid secretion and oxyntic mucosal histamine in rats.
Topics: Animals; Gastric Acid; Gastric Inhibitory Polypeptide; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; Histidine Decarboxylase; Male; Neurotransmitter Agents; Pentagastrin; Peptide Fragments; Rats; Rats, Wistar; Somatostatin; Vasoactive Intestinal Peptide | 1996 |
Glucagon-like peptide-1(7-36)amide increases cyclic AMP accumulation in normal islets.
Topics: Animals; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Peptide Fragments; Rats; Rats, Sprague-Dawley | 1996 |
The amino terminal domain of the glucagon-like peptide-1 receptor is a critical determinant of subtype specificity.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Cyclic AMP; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Peptides; Protein Precursors; Rats; Receptors, Glucagon; Recombinant Fusion Proteins; Venoms | 1996 |
A role for central glucagon-like peptide-1 in temperature regulation.
Topics: Animals; Body Temperature; Body Temperature Regulation; Central Nervous System; Eating; Glucagon; Glucagon-Like Peptide 1; Heart Rate; Injections, Intraperitoneal; Injections, Intraventricular; Male; Peptide Fragments; Protein Precursors; Rats; Telemetry | 1996 |
Concentrations of gut hormones in control and lactating sheep.
Topics: Animals; Eating; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Lactation; Peptide Fragments; Protein Precursors; Reference Values; Sheep | 1996 |
Do gastric inhibitory polypeptide and glucagon-like peptide-1 (7-36) amide contribute to the hyperinsulinaemia of pregnancy?
Topics: Adult; Blood Glucose; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Hyperinsulinism; Insulin; Peptide Fragments; Pregnancy; Pregnancy Complications; Premenopause; Protein Precursors | 1996 |
GLP-1 depolarizes the rat pancreatic beta cell in a Na(+)-dependent manner.
Topics: Animals; Barium; Calcium Channel Blockers; Cell Polarity; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Male; Meglumine; Membrane Potentials; Pancreatic Hormones; Patch-Clamp Techniques; Peptides; Protein Precursors; Rats; Rats, Wistar; Sodium; Sulfonamides | 1996 |
Proglucagon processing in islet and intestinal cell lines.
Topics: Animals; Blotting, Northern; Cell Line; Cricetinae; Furin; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Intestinal Mucosa; Intestines; Islets of Langerhans; Mice; Oxyntomodulin; Peptide Fragments; Proglucagon; Protein Precursors; Protein Processing, Post-Translational; RNA, Messenger; Subtilisins; Transcription, Genetic | 1996 |
Insulinotropic effects of cholecystokinin, gastric inhibitory polypeptide and glucagon-like peptide-1 during perifusion of short-term cultured canine isolated islets.
Topics: Animals; Cells, Cultured; Cholecystokinin; Dogs; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Islets of Langerhans; Peptide Fragments; Peptides; Protein Precursors | 1995 |
Induction of intestinal epithelial proliferation by glucagon-like peptide 2.
Topics: Animals; Cell Division; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Glucagonoma; Ileum; Immunohistochemistry; Intestinal Mucosa; Jejunum; Kinetics; Mice; Mice, Nude; Organ Size; Pancreatic Hormones; Pancreatic Neoplasms; Peptide Fragments; Peptides; Proglucagon; Proliferating Cell Nuclear Antigen; Protein Precursors; Rats; Transplantation, Heterologous | 1996 |
Effects of glucagon and glucagon-like peptide-1-(7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line.
Topics: Animals; Binding, Competitive; Calcitonin; Carcinoma, Medullary; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Peptide Fragments; Perfusion; Rats; Rats, Wistar; Thyroid Gland; Thyroid Neoplasms; Tumor Cells, Cultured | 1996 |
Effects of glucagon-like peptide-I on glucose turnover in rats.
Topics: Animals; Blood Glucose; Eating; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Male; Metabolic Clearance Rate; Peptide Fragments; Rats; Rats, Wistar | 1996 |
Plasma and intestinal concentrations of GIP and GLP-1 (7-36) amide during suckling and after weaning in pigs.
Topics: Animals; Animals, Suckling; Blood Glucose; Food; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Intestinal Mucosa; Milk; Peptide Fragments; Swine; Weaning | 1995 |
Glucagon-like-peptide-1 (7-36) amide improves glucose sensitivity in beta-cells of NOD mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Mice; Mice, Inbred NOD; Mice, Mutant Strains; Pancreas; Peptide Fragments; Time Factors | 1996 |
Inositolphosphoglycans are possible mediators of the glucagon-like peptide 1 (7-36)amide action in the liver.
Topics: Animals; Cell Line, Transformed; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glycogen; Glycogen Synthase; Glycosylphosphatidylinositols; Humans; Liver; Neurotransmitter Agents; Peptide Fragments; Rats | 1996 |
The entero-insular axis in polycystic ovarian syndrome.
Topics: Adult; Blood Glucose; C-Peptide; Case-Control Studies; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Hyperinsulinism; Insulin; Neurotransmitter Agents; Peptide Fragments; Polycystic Ovary Syndrome; Proinsulin | 1996 |
GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1.
Topics: Amino Acid Sequence; Animals; Chloramines; Cyclic AMP; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Gastrointestinal Agents; Glucagon; Glucagon-Like Peptide 1; Indicators and Reagents; Insulinoma; Iodine Radioisotopes; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Radioligand Assay; Rats; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship; Tosyl Compounds; Tumor Cells, Cultured | 1996 |
Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel kinetic app
Topics: Animals; Dipeptidyl Peptidase 4; Enzymes; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hydrolysis; Kinetics; Peptide Fragments; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine | 1996 |
Exchange of W39 by A within the N-terminal extracellular domain of the GLP-1 receptor results in a loss of receptor function.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Membrane; Cells, Cultured; Cricetinae; Cricetulus; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Kinetics; Lymphocytes; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Point Mutation; Protein Precursors; Protein Structure, Secondary; Receptors, Glucagon; Recombinant Proteins; Transfection | 1996 |
Galanin is a potent inhibitor of glucagon-like peptide-1 secretion from rat ileum.
Topics: Animals; Atropine; Galanin; Glucagon; Glucagon-Like Peptide 1; Ileum; Immunohistochemistry; In Vitro Techniques; Intestinal Mucosa; Kinetics; Male; Methacholine Chloride; Neurons; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar | 1996 |
Expression of glucagon-like peptide 1 receptor in a murine C cell line: regulation of calcitonin gene by glucagon-like peptide 1.
Topics: Animals; Base Sequence; Calcitonin; Calcitonin Gene-Related Peptide; Cell Line; DNA Primers; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Kinetics; Molecular Sequence Data; Oligonucleotide Probes; Peptide Fragments; Peptides; Polymerase Chain Reaction; Rats; Receptors, Glucagon; RNA, Messenger; Thyroid Neoplasms; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day.
Topics: Adult; Circadian Rhythm; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Intestine, Small; Male; Peptide Fragments | 1996 |
Glucagon acts through its own receptors in the presence of functional glucagon-like peptide-1 receptors on hamster insulinoma.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Cricetinae; Cross-Linking Reagents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Islets of Langerhans; Mice; Pancreatic Neoplasms; Peptide Fragments; Peptides; Receptors, Glucagon; RNA, Messenger | 1996 |
Signal transduction and desensitization of the glucagon-like peptide-1 receptor.
Topics: Animals; Cyclic AMP; Gene Deletion; Glucagon; Glucagon-Like Peptide 1; Humans; Insulinoma; Mutation; Peptide Fragments; Phosphorylation; Protein Precursors; Receptors, Glucagon; Sensitivity and Specificity; Signal Transduction; Tumor Cells, Cultured | 1996 |
The signal transduction of the glucagon-like peptide 1 receptor: fishing beyond the protein kinase level.
Topics: Colforsin; Electrophoresis, Gel, Two-Dimensional; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Isoelectric Focusing; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Precursors; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured | 1996 |
Glucagon-like peptide-1(7-36)amide and cytoplasmic calcium in insulin producing cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cytoplasm; Fura-2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulinoma; Islets of Langerhans; Male; Neurotransmitter Agents; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Sincalide; Tumor Cells, Cultured | 1996 |
Beta-cell receptors for glucagon/GLP-1? Properties of exendin(9-39) in mouse islets.
Topics: Animals; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Mice; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Venoms | 1996 |
Effects of glucagon-like peptide-1 on membrane potential and ion channels of mouse pancreatic beta-cells.
Topics: Action Potentials; Animals; Calcium Channels; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Microelectrodes; Patch-Clamp Techniques; Peptide Fragments; Protein Precursors | 1996 |
Desensitization and phosphorylation of the glucagon-like peptide-1 (GLP-1) receptor by GLP-1 and 4-phorbol 12-myristate 13-acetate.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Indoles; Insulinoma; Molecular Sequence Data; Pancreatic Neoplasms; Peptide Fragments; Phosphorylation; Protein Kinase C; Protein Precursors; Rats; Receptors, Glucagon; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1996 |
Effects of glucagon-like peptide-1 (GLP-1) in RINm5F insulinoma cells. Stimulation of insulin secretion, insulin content, and insulin receptor binding.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulinoma; Iodine Radioisotopes; Microscopy, Electron; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Receptor, Insulin; Tumor Cells, Cultured | 1995 |
The effect of GIP and glucagon-like peptides on intestinal basolateral membrane hexose transport.
Topics: Animals; Biological Transport; Cell Membrane; Cell Polarity; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Hexoses; Jejunum; Peptide Fragments; Peptides; Protein Precursors; Rats | 1996 |
Colocalization of glucagon-like peptide-1 (GLP-1) receptors, glucose transporter GLUT-2, and glucokinase mRNAs in rat hypothalamic cells: evidence for a role of GLP-1 receptor agonists as an inhibitory signal for food and water intake.
Topics: Animals; Cerebral Ventricles; Drinking Behavior; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucokinase; Glucose Transporter Type 2; Hypothalamus; In Situ Hybridization; Injections, Intraventricular; Male; Monosaccharide Transport Proteins; Neurotransmitter Agents; Peptide Fragments; Peptides; Rats; Rats, Wistar; Receptors, Glucagon; RNA, Messenger; Signal Transduction; Transcription, Genetic | 1996 |
Normalization of insulin responses to glucose by overnight infusion of glucagon-like peptide 1 (7-36) amide in patients with NIDDM.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Homeostasis; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Models, Biological; Neurotransmitter Agents; Peptide Fragments; Reference Values; Time Factors | 1996 |
Ligand-induced regulation of glucagon-like peptide-I receptor function and expression in insulin-secreting beta cells.
Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Tumor Cells, Cultured | 1996 |
Studies on the viability of the isolated vascularly perfused rat colon.
Topics: Animals; Cell Survival; Colon; Glucagon; Glucagon-Like Peptide 1; Glucose; In Vitro Techniques; Intestinal Mucosa; L Cells; L-Lactate Dehydrogenase; Lactates; Male; Mice; Oxygen Consumption; Peptide Fragments; Perfusion; Protein Precursors; Rats; Rats, Wistar | 1996 |
Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets.
Topics: Animals; Binding, Competitive; Cell Line; Cells, Cultured; Eating; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Immunohistochemistry; Insulin; Islets of Langerhans; Kinetics; Male; Models, Biological; Peptide Fragments; Protein Precursors; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Somatostatin | 1996 |
Glucagon-like peptide-1(7-36) amide and glycogen synthesis in the liver.
Topics: Animals; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Kinetics; Liver; Liver Glycogen; Peptide Fragments; Rats | 1996 |
Central administration of GLP-1-(7-36) amide inhibits food and water intake in rats.
Topics: Animals; Behavior, Animal; Brain; Drinking; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intraventricular; Male; Natriuresis; Peptide Fragments; Rats; Rats, Wistar | 1996 |
Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain.
Topics: Animals; Brain; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Immunohistochemistry; Injections, Intraventricular; Leptin; Male; Peptide Fragments; Proteins; Proto-Oncogene Proteins c-fos; Rats; Rats, Inbred Strains; Tissue Distribution | 1996 |
Glucose intolerance but normal satiety in mice with a null mutation in the glucagon-like peptide 1 receptor gene.
Topics: Animals; Blood Glucose; Female; Gene Deletion; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose Intolerance; Insulin; Male; Mice; Peptide Fragments; Protein Precursors; Rats; Receptors, Glucagon | 1996 |
Potentiation of GLP-1 insulinotropic action by a nonglucidic nutrient in the pancreas of diabetic GK rats.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Insulin; Male; Pancreas; Peptide Fragments; Protein Precursors; Rats; Succinates | 1996 |
Inositolphosphoglycans and diacyglycerol are possible mediators in the glycogenic effect of GLP-1(7-36)amide in BC3H-1 myocytes.
Topics: Animals; Diglycerides; Glucagon; Glucagon-Like Peptide 1; Glycogen; Glycosylphosphatidylinositols; Inositol Phosphates; Insulin; Insulin Antagonists; Mice; Mice, Inbred Strains; Muscle Fibers, Skeletal; Muscle, Skeletal; Peptide Fragments; Polysaccharides; Protein Binding; Protein Precursors | 1996 |
Gut incretin hormones in identical twins discordant for non-insulin-dependent diabetes mellitus (NIDDM)--evidence for decreased glucagon-like peptide 1 secretion during oral glucose ingestion in NIDDM twins.
Topics: Administration, Oral; Area Under Curve; Body Mass Index; Diabetes Mellitus, Type 2; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Intestinal Mucosa; Male; Middle Aged; Neurotransmitter Agents; Peptide Fragments; Protein Precursors; Sex Characteristics | 1996 |
The enteroinsular axis in dipeptidyl peptidase IV-negative rats.
Topics: Animals; Dipeptidyl Peptidase 4; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Insulin; Insulin Secretion; Peptide Fragments; Perfusion; Rats; Rats, Inbred F344 | 1996 |
Effects of somatostatin-28 on circulating concentrations of insulin and gut hormones in sheep.
Topics: Animals; Depression, Chemical; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Peptide Fragments; Protein Precursors; Sheep; Somatostatin; Somatostatin-28 | 1996 |
Vagal hepatopancreatic reflex effect evoked by intraportal appearance of tGLP-1.
Topics: Afferent Pathways; Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intravenous; Liver; Male; Pancreas; Peptide Fragments; Portal Vein; Protein Precursors; Rats; Rats, Wistar; Reflex; Time Factors; Vagus Nerve | 1996 |
The hepatic vagal nerve is receptive to incretin hormone glucagon-like peptide-1, but not to glucose-dependent insulinotropic polypeptide, in the portal vein.
Topics: Afferent Pathways; Animals; Electrophysiology; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intravenous; Liver; Male; Neurotransmitter Agents; Peptide Fragments; Portal Vein; Rats; Rats, Wistar; Vagus Nerve | 1996 |
The isolated N-terminal extracellular domain of the glucagon-like peptide-1 (GLP)-1 receptor has intrinsic binding activity.
Topics: Amino Acid Sequence; Animals; Binding Sites; Binding, Competitive; Cricetinae; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Protein Precursors; Rabbits; Rats; Receptors, Glucagon; Recombinant Proteins; Solubility | 1996 |
Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats.
Topics: Animals; Blood Pressure; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Heart Rate; Male; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Venoms | 1996 |
The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity, and age in women.
Topics: Adipose Tissue; Adolescent; Adult; Age Factors; Aged; Diabetes Mellitus, Type 2; Exercise; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Hyperinsulinism; Leptin; Middle Aged; Peptide Fragments; Protein Precursors; Proteins; Weight Loss | 1996 |
Truncated glucagon-like peptide-1 and oxyntomodulin stimulate somatostatin release from rabbit fundic D-cells in primary culture.
Topics: Animals; Cells, Cultured; Gastric Acid; Gastric Fundus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Oxyntomodulin; Peptide Fragments; Rabbits; Somatostatin | 1996 |
Attenuated GLP-1 secretion in obesity: cause or consequence?
Topics: Adult; Case-Control Studies; Dietary Carbohydrates; Dietary Fats; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Heparin; Humans; Obesity; Peptide Fragments; Radioimmunoassay | 1996 |
Postprandial glucose-dependent insulinotropic polypeptide and insulin responses in patients with chronic pancreatitis with and without secondary diabetes.
Topics: Adult; Age Factors; Diabetes Mellitus; Digestion; Exocrine Pancreatic Insufficiency; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Male; Middle Aged; Pancreatitis; Peptide Fragments; Postprandial Period; Sex Factors | 1996 |
Effect of PACAP, VIP, glucagon, and GLP1 on cAMP production and insulin release of HIT-T15 cells is passage dependent.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Line, Transformed; Colforsin; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Swine; Vasoactive Intestinal Peptide | 1996 |
Glucagon-like peptide-1 and satiety.
Topics: Animals; Avoidance Learning; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Neuropeptides; Peptide Fragments; Proto-Oncogene Proteins c-fos; Rats; Saccharin; Satiety Response; Taste | 1997 |
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Pancreatic Neoplasms; Peptide Fragments; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Glucagon-like peptide-1-(9-36) amide is a major metabolite of glucagon-like peptide-1-(7-36) amide after in vivo administration to dogs, and it acts as an antagonist on the pancreatic receptor.
Topics: Animals; Chromatography, High Pressure Liquid; Cricetinae; Dogs; Enzyme-Linked Immunosorbent Assay; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Pancreas; Peptide Fragments; Radioimmunoassay; Receptors, Glucagon | 1996 |
Effects of glucagon-like peptide-1 on islet function and insulin sensitivity in noninsulin-dependent diabetes mellitus.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Peptides | 1997 |
Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem.
Topics: Animals; Chromatography, Gel; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; In Situ Hybridization; Male; Nerve Fibers; Neurosecretion; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; RNA, Messenger; Solitary Nucleus; Supraoptic Nucleus | 1997 |
[Glucagon-like peptide 1--a new physiologic mediator of satiety?].
Topics: Animals; Brain; Brain Mapping; Eating; Glucagon; Glucagon-Like Peptide 1; Peptide Fragments; Protein Precursors; Rats; Satiety Response | 1996 |
Incretin hormone expression in the gut of diabetic mice and rats.
Topics: Animals; Blotting, Northern; Colon; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Gastric Inhibitory Polypeptide; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Intestinal Mucosa; Intestine, Small; Intestines; Mice; Mice, Inbred NOD; Peptide Fragments; Proglucagon; Protein Precursors; Rats; Rats, Zucker; Rectum; RNA, Messenger; Tissue Distribution | 1997 |
Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucose-dependent insulinotropic polypeptide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Exocytosis; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Peptide Fragments; Phosphodiesterase Inhibitors; Tetradecanoylphorbol Acetate; Thionucleotides | 1997 |
Tissue-specific and glucose-dependent expression of receptor genes for glucagon and glucagon-like peptide-1 (GLP-1).
Topics: Animals; DNA, Complementary; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulinoma; Islets of Langerhans; Mice; Mice, Inbred C57BL; Peptides; Protein Biosynthesis; Protein Precursors; RNA, Messenger; Tissue Distribution; Tumor Cells, Cultured | 1997 |
Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism.
Topics: Animals; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; Exocytosis; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Peptide Fragments; Rats; Somatostatin | 1997 |
Blood glucose lowering and glucagonostatic effects of glucagon-like peptide I in insulin-deprived diabetic dogs.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Dogs; Female; Glucagon; Glucagon-Like Peptide 1; Insulin; Male; Peptide Fragments; Protein Precursors; Urea | 1997 |
Exendin-4 agonist and exendin(9-39)amide antagonist of the GLP-1(7-36)amide effects in liver and muscle.
Topics: Animals; Cyclic AMP; Energy Metabolism; Enzyme Activation; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glycogen; Glycogen Synthase; Insulin; Liver; Muscle, Skeletal; Peptide Fragments; Peptides; Phosphorylase a; Rats; Rats, Wistar; Venoms | 1997 |
Intracerebroventricular injection of mammalian and chicken glucagon-like peptide-1 inhibits food intake of the neonatal chick.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Animals, Newborn; Chickens; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Feeding Behavior; Female; Glucagon; Glucagon-Like Peptide 1; Injections, Intraventricular; Male; Mammals; Molecular Sequence Data; Peptides; Sequence Homology, Amino Acid; Species Specificity | 1997 |
Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor.
Topics: Adenylyl Cyclases; Animals; Binding Sites; Binding, Competitive; CHO Cells; Cloning, Molecular; COS Cells; Cricetinae; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Kinetics; Models, Structural; Peptide Fragments; Protein Precursors; Protein Structure, Secondary; Rats; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Recombinant Fusion Proteins; Signal Transduction; Transfection | 1997 |
The release of gastric inhibitory peptide, glucagon-like peptide-I, and insulin after oral glucose test in colectomized subjects.
Topics: Adult; Blood Glucose; Colectomy; Colitis, Ulcerative; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Ileostomy; Insulin; Insulin Secretion; Intestinal Mucosa; Male; Middle Aged; Peptide Fragments; Proctocolectomy, Restorative; Protein Precursors | 1997 |
The inhibitory effect of glucagon-like peptide-1 (GLP-1) 7-36 amide on gastric acid secretion in humans depends on an intact vagal innervation.
Topics: Adult; Aged; Blood Glucose; Duodenal Ulcer; Female; Gastric Acid; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Male; Middle Aged; Pentagastrin; Peptide Fragments; Vagotomy | 1997 |
Cloning and characterization of the 5' flanking sequences (promoter region) of the human GLP-1 receptor gene.
Topics: Base Sequence; Cloning, Molecular; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulinoma; Molecular Sequence Data; Peptide Fragments; Promoter Regions, Genetic; Receptors, Glucagon; Sequence Analysis, DNA; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Endoproteolysis of glucagon-like peptide (GLP)-1 (7-36) amide by ectopeptidases in RINm5F cells.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hydrolysis; Insulinoma; Peptide Fragments; Peptide Hydrolases; Rats; Tumor Cells, Cultured | 1997 |
The Xenopus proglucagon gene encodes novel GLP-1-like peptides with insulinotropic properties.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA, Complementary; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Insulin Secretion; Molecular Sequence Data; Peptide Fragments; Proglucagon; Protein Precursors; Rats; Receptors, Glucagon; Second Messenger Systems; Sequence Homology, Amino Acid; Xenopus laevis | 1997 |
Absence of short-term effects of glucagon-like peptide-1 and of hyperglycemia on plasma leptin levels in man.
Topics: Adult; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Hyperglycemia; Leptin; Male; Osmolar Concentration; Peptide Fragments; Protein Precursors; Proteins | 1997 |
Extrapancreatic action of truncated glucagon-like peptide-I in Otsuka Long-Evans Tokushima Fatty rats, an animal model for non-insulin-dependent diabetes mellitus.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Infusion Pumps; Insulin; Male; Pancreas; Peptide Fragments; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Rats, Mutant Strains | 1997 |
Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors.
Topics: Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activation; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Neurotransmitter Agents; Peptide Fragments; Peptides; Receptors, Cell Surface | 1997 |
Cardiovascular and pancreatic endocrine responses to glucagon-like peptide-1(7-36) amide in the conscious calf.
Topics: Amino Acids; Animals; Blood Glucose; Blood Pressure; Cattle; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Heart Rate; Insulin; Insulin Secretion; Islets of Langerhans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Pancreatic Polypeptide; Peptide Fragments | 1997 |
High potency antagonists of the pancreatic glucagon-like peptide-1 receptor.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Exenatide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Molecular Sequence Data; Peptide Fragments; Peptides; Rats; Receptors, Glucagon; Recombinant Fusion Proteins; Sequence Deletion; Structure-Activity Relationship; Transfection; Venoms | 1997 |
GLP-1 (7-36) amide activates L-type Ca2+ channels of pancreatic B-cells through c-AMP signaling.
Topics: Action Potentials; Animals; Barium; Calcium Channels; Cyclic AMP; Electric Conductivity; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Male; Peptide Fragments; Rats; Signal Transduction | 1997 |
Ontogenic changes in proglucagon mRNA in BB diabetes prone and normal rats weaned onto a chow diet.
Topics: Age Factors; Animals; Blood Glucose; Colon; Diabetes Mellitus, Type 1; Diet; Female; Gene Expression Regulation, Developmental; Glucagon; Glucagon-Like Peptide 1; Glucose Transporter Type 1; Glucose Transporter Type 2; Intestine, Small; Male; Membrane Glycoproteins; Monosaccharide Transport Proteins; Peptide Fragments; Proglucagon; Protein Precursors; Rats; Rats, Inbred BB; RNA, Messenger; Sodium-Glucose Transporter 1 | 1997 |
Identification of amidated forms of GLP-1 in rat tissues using a highly sensitive radioimmunoassay.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hypothalamus; Ileum; Immune Sera; Intubation, Gastrointestinal; Male; Organ Specificity; Pancreas; Peptide Fragments; Peptides; Rabbits; Radioimmunoassay; Rats; Rats, Wistar | 1997 |
Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Binding, Competitive; Calcium; CHO Cells; Cricetinae; Cyclic AMP; Exenatide; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Lipolysis; Mice; Peptide Fragments; Peptides; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Signal Transduction; Venoms | 1997 |
Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Blood Glucose; Corticosterone; Corticotropin-Releasing Hormone; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamo-Hypophyseal System; Hypothalamus; Immunohistochemistry; Injections, Intraventricular; Male; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Phenotype; Pituitary-Adrenal System; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Supraoptic Nucleus; Time Factors; Vasopressins | 1997 |
Decreased intake of a liquid diet in nonfood-deprived rats following intra-PVN injections of GLP-1 (7-36) amide.
Topics: Adrenergic alpha-Agonists; Animals; Depression, Chemical; Diet; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Male; Microinjections; Neurotransmitter Agents; Norepinephrine; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Rats, Sprague-Dawley | 1997 |
Comparison of Fos induced in rat brain by GLP-1 and amylin.
Topics: Amyloid; Angiotensin II; Animals; Bombesin; Brain; Cholecystokinin; Glucagon; Glucagon-Like Peptide 1; Islet Amyloid Polypeptide; Male; Oncogene Proteins v-fos; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 1997 |
Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents.
Topics: Animals; Body Weight; Carrier Proteins; DNA Probes; Eating; Gene Expression; Glucagon; Glucagon-Like Peptide 1; In Situ Hybridization; Leptin; Light; Male; Mice; Mice, Inbred Strains; Neurons; Peptide Fragments; Proglucagon; Protein Precursors; Proteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Leptin; RNA, Messenger; Solitary Nucleus | 1997 |
GLP-I(7-36) amide augments Ba2+ current through L-type Ca2+ channel of rat pancreatic beta-cell in a cAMP-dependent manner.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Barium; Bucladesine; Calcium Channels; Calcium Channels, L-Type; Cells, Cultured; Cyclic AMP; Electric Stimulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islets of Langerhans; Kinetics; Membrane Potentials; Peptide Fragments; Rats; Thionucleotides; Tolbutamide | 1997 |
Activation of the hepatic glycine cleavage enzyme system by glucagon and glucagon-related peptides.
Topics: Animals; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycine; In Vitro Techniques; Liver; Male; Oxyntomodulin; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 1997 |
GLP-1 (7-36) amide: effects on glucose transport and metabolism in rat adipose tissue.
Topics: Adipose Tissue; Animals; Biological Transport; Deoxyglucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glycogen; Insulin; Lipids; Male; Oxidation-Reduction; Peptide Fragments; Rats; Rats, Wistar | 1997 |
Methods for the investigation of neuropeptide catabolism and stability in vitro.
Topics: Animals; Blood Physiological Phenomena; Brain; Cell Line; Cells, Cultured; Chromatography, High Pressure Liquid; Drug Stability; Enkephalin, Leucine; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Microglia; Neuropeptides; Peptide Fragments; Rats; Rats, Wistar; Somatostatin | 1997 |
Ileal carbohydrates inhibit cholinergically stimulated exocrine pancreatic secretion in humans.
Topics: Adult; Amylases; Carbachol; Carbohydrate Metabolism; Carbohydrates; Cholinergic Fibers; Glucagon; Glucagon-Like Peptide 1; Humans; Ileum; Lipase; Pancreas; Peptide Fragments; Peptide YY; Protein Precursors; Trypsin | 1997 |
Regulation of growth hormone secretion in lactating sheep.
Topics: Animals; Eating; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Growth Hormone; Homeostasis; Lactation; Peptide Fragments; Sheep | 1997 |
Effects of non-glycated and glycated glucagon-like peptide-1(7-36) amide on glucose metabolism in isolated mouse abdominal muscle.
Topics: Abdominal Muscles; Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glycosylation; In Vitro Techniques; Insulin; Male; Mice; Oxidation-Reduction; Peptide Fragments; Peptides | 1997 |
Elevated post-prandial gastric inhibitory polypeptide concentrations in hypertriglyceridaemic subjects.
Topics: Adult; Blood Glucose; Cholesterol; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hyperinsulinism; Hypertriglyceridemia; Male; Middle Aged; Peptide Fragments; Postprandial Period; Statistics, Nonparametric | 1997 |
Anchoring of protein kinase A facilitates hormone-mediated insulin secretion.
Topics: Animals; Calcium; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Pancreas; Peptide Fragments; Protein Precursors; Rats | 1997 |
Role of the prohormone convertase PC3 in the processing of proglucagon to glucagon-like peptide 1.
Topics: Animals; Aspartic Acid Endopeptidases; Cells, Cultured; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Kinetics; Mice; Oxyntomodulin; Peptide Fragments; Proglucagon; Proprotein Convertases; Protein Precursors; Rats; Recombinant Proteins; Tumor Cells, Cultured | 1997 |
Endogenous somatostatin-28 modulates postprandial insulin secretion. Immunoneutralization studies in baboons.
Topics: Animals; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Growth Hormone; Immunologic Techniques; Insulin; Insulin Secretion; Male; Papio; Peptides; Postprandial Period; Somatostatin; Somatostatin-28 | 1997 |
Glucagon-like peptide-1(7-36)-amide confers glucose sensitivity to previously glucose-incompetent beta-cells in diabetic rats: in vivo and in vitro studies.
Topics: Animals; Culture Techniques; Cyclic AMP; Diabetes Mellitus, Experimental; DNA; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans; Male; Neurotransmitter Agents; Peptide Fragments; Perfusion; Rats; Rats, Wistar | 1997 |
Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling.
Topics: Adult; Calcium; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exocytosis; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Islets of Langerhans; Male; Membrane Potentials; Middle Aged; Neurotransmitter Agents; Peptide Fragments; Potassium Channels; Somatostatin | 1998 |
Dual glucagon recognition by pancreatic beta-cells via glucagon and glucagon-like peptide 1 receptors.
Topics: Animals; Cells, Cultured; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Iodine Radioisotopes; Islets of Langerhans; Liver; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 1998 |
Glucagon-like peptide-1-(7-36) amide and peptide YY mediate intraduodenal fat-induced inhibition of acid secretion in dogs.
Topics: Animals; Benzodiazepinones; Devazepide; Dogs; Duodenum; Fats; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Peptide Fragments; Peptide YY; Protein Precursors | 1998 |
Transplantable rat glucagonomas cause acute onset of severe anorexia and adipsia despite highly elevated NPY mRNA levels in the hypothalamic arcuate nucleus.
Topics: Animals; Anorexia; Arcuate Nucleus of Hypothalamus; Drinking; Female; Glucagon; Glucagon-Like Peptide 1; Glucagonoma; Male; Neoplasm Transplantation; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; RNA, Messenger; Weight Loss | 1998 |
PVN infusion of GLP-1-(7-36) amide suppresses feeding but does not induce aversion or alter locomotion in rats.
Topics: Animals; Avoidance Learning; Cerebral Ventricles; Drinking Behavior; Feeding Behavior; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Infusions, Parenteral; Male; Motor Activity; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Stereotyped Behavior; Time Factors | 1998 |
Regulation of glucose transporters and hexose uptake in 3T3-L1 adipocytes: glucagon-like peptide-1 and insulin interactions.
Topics: 3T3 Cells; Adipocytes; Animals; Cyclic AMP; Deoxyglucose; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose Transporter Type 1; Glucose Transporter Type 4; Hexoses; Hypoglycemic Agents; Insulin; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Peptide Fragments; Protein Binding; Protein Precursors; Receptor, Insulin; RNA, Messenger | 1997 |
The positive charge of the imidazole side chain of histidine7 is crucial for GLP-1 action.
Topics: Animals; Binding, Competitive; Cricetinae; DNA, Complementary; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Histidine; Imidazoles; Peptide Fragments; Protein Precursors; Rats; Receptors, Glucagon; Signal Transduction; Transfection | 1997 |
The concentrations of some gut polypeptides are elevated during lactation in ruminants.
Topics: Animals; Blood Glucose; Fatty Acids; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Insulin; Lactation; Peptide Fragments; Protein Precursors; Sheep | 1997 |
The central corticotropin-releasing factor and glucagon-like peptide-1 in food intake of the neonatal chick.
Topics: Animals; Animals, Newborn; Chickens; Corticosterone; Corticotropin-Releasing Hormone; Eating; Feeding Behavior; Female; Glucagon; Glucagon-Like Peptide 1; Male; Peptide Fragments; Protein Precursors | 1997 |
Intraventricular GLP-1 reduces short- but not long-term food intake or body weight in lean and obese rats.
Topics: Analysis of Variance; Animals; Body Weight; Cerebral Ventricles; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Infusion Pumps, Implantable; Male; Obesity; Peptide Fragments; Protein Precursors; Rats; Rats, Zucker; Time Factors | 1998 |
Interaction of GLP-I and leptin at rat pancreatic B-cells: effects on insulin secretion and signal transduction.
Topics: Animals; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Male; Peptide Fragments; Protein Binding; Protein Precursors; Proteins; Rats; Rats, Wistar; Receptors, Glucagon; Recombinant Proteins; Signal Transduction; Tumor Cells, Cultured | 1997 |
[Ca2+]i-reducing action of cAMP in rat pancreatic beta-cells: involvement of thapsigargin-sensitive stores.
Topics: Animals; Bucladesine; Calcium; Cyclic AMP; Cytosol; Endoplasmic Reticulum; Energy Metabolism; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; NADP; Peptide Fragments; Potassium Chloride; Protein Precursors; Rats; Rats, Wistar; Sodium-Calcium Exchanger; Thapsigargin | 1998 |
Effects of VIP and related peptides on airway mucus secretion from isolated rat trachea.
Topics: Animals; Exenatide; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Mucus; Neuropeptides; Peptide Fragments; Peptide PHI; Peptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Protease Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Thiorphan; Trachea; Vasoactive Intestinal Peptide; Venoms | 1998 |
Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line.
Topics: Animals; Calcium; Cyclic AMP; Cytoplasm; Dose-Response Relationship, Drug; Exenatide; Food Deprivation; Glucagon; Glucagon-Like Peptide 1; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Male; Mice; Mice, Transgenic; Neurons; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Cell Surface; Time Factors; Tumor Cells, Cultured; Venoms | 1998 |
Delayed gastric emptying occurs following acarbose administration and is a further mechanism for its anti-hyperglycaemic effect.
Topics: Acarbose; Acetaminophen; Blood Glucose; Dietary Sucrose; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Middle Aged; Peptide Fragments; Protein Precursors; Reference Values; Trisaccharides | 1998 |
Consideration of conformational transitions and racemization during process development of recombinant glucagon-like peptide-1.
Topics: Chemical Precipitation; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Excipients; Glucagon; Glucagon-Like Peptide 1; Hydrogen-Ion Concentration; Kinetics; Peptide Fragments; Protein Conformation; Protein Precursors; Protein Structure, Secondary; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared; Temperature | 1998 |
Effects of non-covalent self-association on the subcutaneous absorption of a therapeutic peptide.
Topics: Amino Acid Sequence; Animals; Chromatography, Gel; Circular Dichroism; Dogs; Female; Glucagon; Glucagon-Like Peptide 1; Injections, Subcutaneous; Insulin; Light; Male; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Scattering, Radiation; Spectrophotometry, Infrared | 1998 |
Proglucagon processing in an islet cell line: effects of PC1 overexpression and PC2 depletion.
Topics: Animals; Aspartic Acid Endopeptidases; Cell Line; DNA, Antisense; Gene Expression; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Islets of Langerhans; Mice; Oxyntomodulin; Peptide Fragments; Peptides; Proglucagon; Proprotein Convertase 1; Proprotein Convertase 2; Proprotein Convertases; Protein Precursors; RNA, Messenger; Subtilisins; Transfection | 1998 |
Glucagon-like-peptide-1 secretion from canine L-cells is increased by glucose-dependent-insulinotropic peptide but unaffected by glucose.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dogs; Enteroendocrine Cells; Enzyme Activation; Enzyme Inhibitors; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Immunohistochemistry; Isoquinolines; Male; Peptide Fragments; Protein Kinase C; Protein Precursors; Somatostatin; Tetradecanoylphorbol Acetate | 1998 |
Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity.
Topics: Animals; Cross Reactions; Dipeptidyl Peptidase 4; Drug Stability; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; In Vitro Techniques; Insulin; Insulin Secretion; Pancreas; Peptide Fragments; Perfusion; Protein Binding; Protein Precursors; Receptors, Glucagon; Swine | 1998 |
The human glucagon-like peptide-1 (GLP-1) receptor. Cloning and functional expression.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Calcium; Cloning, Molecular; COS Cells; Cyclic AMP; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Kinetics; Molecular Sequence Data; Peptide Fragments; Peptides; Polymerase Chain Reaction; Protein Precursors; Rats; Receptors, Glucagon; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Transfection | 1997 |
Cyclic AMP, a mediator of GLP-1, acts in concert with glucose and tolbutamide to increase cytosolic Ca2+ in pancreatic B-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islets of Langerhans; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide | 1997 |
Effect of chronic central administration of glucagon-like peptide-1 (7-36) amide on food consumption and body weight in normal and obese rats.
Topics: Animals; Body Weight; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intraventricular; Insulinoma; Male; Neurotransmitter Agents; Obesity; Pancreatic Neoplasms; Peptide Fragments; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Glucagon; Tumor Cells, Cultured | 1998 |
A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events.
Topics: A Kinase Anchor Proteins; Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Calcium Channels; Carrier Proteins; Cell Line; Cell Membrane; Cloning, Molecular; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Electric Conductivity; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Membrane Proteins; Mice; Molecular Sequence Data; Peptide Fragments; Peptide Mapping; Protein Kinases; Protein Precursors; Sequence Homology, Amino Acid | 1998 |
Molecular cloning of the helodermin and exendin-4 cDNAs in the lizard. Relationship to vasoactive intestinal polypeptide/pituitary adenylate cyclase activating polypeptide and glucagon-like peptide 1 and evidence against the existence of mammalian homolog
Topics: Amino Acid Sequence; Animals; Base Sequence; Chickens; Cloning, Molecular; DNA Primers; DNA, Complementary; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Intercellular Signaling Peptides and Proteins; Lizards; Mammals; Molecular Sequence Data; Neuropeptides; Peptide Fragments; Peptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Polymerase Chain Reaction; Protein Precursors; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Trout; Vasoactive Intestinal Peptide; Venoms | 1998 |
Inhibition of human gastric lipase secretion by glucagon-like peptide-1.
Topics: Aged; Case-Control Studies; Female; Gastric Acid; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Lipase; Male; Middle Aged; Pentagastrin; Peptide Fragments; Protein Precursors; Stimulation, Chemical; Vagotomy | 1998 |
Effect of euglycaemic hyperinsulinaemia on gastric emptying and gastrointestinal hormone responses in normal subjects.
Topics: Adult; Amyloid; Blood Glucose; C-Peptide; Gastric Emptying; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Infusions, Intravenous; Insulin; Islet Amyloid Polypeptide; Male; Pentetic Acid; Peptide Fragments; Protein Precursors; Radiopharmaceuticals; Reference Values; Technetium; Time Factors | 1998 |
Glucagon-like peptide-1-(7-36)amide increases pulmonary surfactant secretion through a cyclic adenosine 3',5'-monophosphate-dependent protein kinase mechanism in rat type II pneumocytes.
Topics: Adrenergic beta-Agonists; Animals; Calcimycin; Calcium-Transporting ATPases; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Kinetics; Lung; Male; Peptide Fragments; Phosphatidylcholines; Pulmonary Surfactants; Rats; Rats, Wistar; Terbutaline; Tetradecanoylphorbol Acetate; Thapsigargin | 1998 |
Glucagon-like peptide 1(7-36) amide's central inhibition of feeding and peripheral inhibition of drinking are abolished by neonatal monosodium glutamate treatment.
Topics: Angiotensin II; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Avoidance Learning; Blood Glucose; Blood-Brain Barrier; Brain; Cerebral Ventricles; Drinking; Eating; Food Additives; Food Deprivation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Male; Neuropeptide Y; Peptide Fragments; Rats; Rats, Wistar; Sodium Glutamate; Subfornical Organ; Taste | 1998 |
Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.
Topics: Alleles; Animals; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Homeostasis; Insulin; Intestinal Mucosa; Male; Mice; Mutation; Pancreas; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Radioimmunoassay; Receptors, Glucagon; RNA, Messenger; Signal Transduction | 1998 |
Mouse pancreatic beta-cells exhibit preserved glucose competence after disruption of the glucagon-like peptide-1 receptor gene.
Topics: Animals; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Organ Specificity; Peptide Fragments; Protein Precursors; Receptors, Glucagon; RNA, Messenger | 1998 |
Effects of glucagon-like peptide 1 (7-36 amide) on glucose kinetics during somatostatin-induced suppression of insulin secretion in healthy men.
Topics: Adult; Blood Glucose; C-Peptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Humans; Hyperglycemia; Infusions, Intravenous; Insulin; Insulin Secretion; Kinetics; Male; Peptide Fragments; Proinsulin; Somatostatin | 1998 |
Inositolphosphoglycans possibly mediate the effects of glucagon-like peptide-1(7-36)amide on rat liver and adipose tissue.
Topics: Adipocytes; Adipose Tissue; Animals; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycosylphosphatidylinositols; Liver; Male; Peptide Fragments; Rats; Rats, Wistar | 1998 |
Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.
Topics: Anesthetics; Animals; Dipeptidyl Peptidase 4; Drug Evaluation, Preclinical; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Infusions, Intravenous; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors; Pyrroles; Secretory Rate; Swine; Valine | 1998 |
Effects of glucagon-like peptide 1 on the kinetics of glycogen synthase a in hepatocytes from normal and diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycogen Synthase; Isoenzymes; Kinetics; Liver; Male; Peptide Fragments; Phosphorylase a; Protein Precursors; Rats; Rats, Wistar; Reference Values | 1998 |
Plasma glucagon-like peptide-1 (7-36) amide (GLP-1) response to liquid phase, solid phase, and meals of differing lipid composition.
Topics: Adult; Beverages; Blood Glucose; Dietary Fats; Dietary Fats, Unsaturated; Energy Intake; Female; Food; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Kinetics; Male; Peptide Fragments | 1998 |
Galanin inhibits glucagon-like peptide-1 secretion through pertussis toxin-sensitive G protein and ATP-dependent potassium channels in rat ileal L-cells.
Topics: Animals; Bombesin; Cells, Cultured; Colforsin; Disopyramide; Dose-Response Relationship, Drug; Galanin; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; GTP-Binding Proteins; Ileum; Immunohistochemistry; Male; Microscopy, Fluorescence; Peptide Fragments; Pertussis Toxin; Potassium Channels; Protein Precursors; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1998 |
Effects of GLP-1 on gastric emptying, antropyloric motility, and transpyloric flow in response to a nonnutrient liquid.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Peptide Fragments; Pressure; Protein Precursors; Pylorus | 1998 |
Peptones stimulate both the secretion of the incretin hormone glucagon-like peptide 1 and the transcription of the proglucagon gene.
Topics: Animals; Cell Line; Culture Media, Conditioned; Dose-Response Relationship, Drug; Enteroendocrine Cells; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Intestines; Kinetics; Male; Mice; Peptide Fragments; Peptones; Perfusion; Proglucagon; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Wistar; RNA; Transcription, Genetic; Transfection | 1998 |
A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cations; Cell Membrane; Disulfides; Dithiothreitol; Electric Conductivity; Glucagon; Glucagon-Like Peptide 1; Humans; Ion Channels; Ionophores; Islets of Langerhans; Marine Toxins; Membrane Potentials; Mice; Oxocins; Peptide Fragments; Potassium Channels; Protein Precursors; Trypsin; Tumor Cells, Cultured | 1998 |
Insulin, glucagon-like peptide 1, glucose-dependent insulinotropic polypeptide and insulin-like growth factor I as putative mediators of the hypolipidemic effect of oligofructose in rats.
Topics: Animals; Blood Glucose; Cecum; Eating; Fructose; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hypolipidemic Agents; Insulin; Insulin-Like Growth Factor I; Intestine, Small; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Weight Gain | 1998 |
Sympathetic pathways mediate GLP-1 actions in the gastrointestinal tract of the rat.
Topics: Animals; Digestive System; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Male; Myoelectric Complex, Migrating; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 1998 |
Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia.
Topics: Adrenocorticotropic Hormone; Adult; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Humans; Hydrocortisone; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Peptide Fragments; Peptides; Reference Values; Secretory Rate; Somatostatin | 1998 |
Differential effects of intracerebroventricular glucagon-like peptide-1 on feeding and energy expenditure regulation.
Topics: Analysis of Variance; Animals; Drinking Behavior; Energy Metabolism; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Injections, Intraventricular; Male; Obesity; Peptide Fragments; Protein Precursors; Rats; Rats, Zucker | 1998 |
The inhibitory effect of glucagon-like peptide-1 (7-36)amide on antral motility is antagonized by its N-terminally truncated primary metabolite GLP-1 (9-36)amide.
Topics: Animals; Dose-Response Relationship, Drug; Gastrointestinal Hormones; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypoglycemia; Peptide Fragments; Peptides; Pyloric Antrum; Swine | 1998 |
Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity.
Topics: Adult; Blood Glucose; Body Mass Index; Case-Control Studies; Female; Follow-Up Studies; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Intestine, Small; Jejunoileal Bypass; Middle Aged; Peptide Fragments; Postprandial Period; Protein Precursors; Time Factors; Weight Loss | 1998 |
Purification and characterization of insulin, glucagon, and two glucagon-like peptides with insulin-releasing activity from the pancreas of the toad, Bufo marinus.
Topics: Amino Acid Sequence; Animals; Bufo marinus; Chromatography, High Pressure Liquid; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Insulin; Male; Molecular Sequence Data; Pancreas; Peptides; Receptor, Insulin; Sequence Homology | 1998 |
Potentiated beta-cell response to non-glucose stimuli in insulin-resistant C57BL/6J mice.
Topics: Animals; Antimetabolites; Blood Glucose; Body Weight; Carbachol; Deoxyglucose; Diet; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Peptide Fragments; Protein Precursors; Sincalide; Stimulation, Chemical | 1998 |
Relation between gastric emptying of glucose and plasma concentrations of glucagon-like peptide-1.
Topics: Adult; Body Mass Index; Body Weight; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Male; Peptide Fragments; Protein Precursors; Time Factors | 1998 |
Glucagon-like peptide 1 improves the ability of the beta-cell to sense and respond to glucose in subjects with impaired glucose tolerance.
Topics: Administration, Oral; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Peptide Fragments; Protein Precursors | 1998 |
Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed motility inhibited via nitric oxide independently of insulin and somatostatin.
Topics: Animals; Drug Interactions; Eating; Electromyography; Fasting; Gastrointestinal Motility; Gastrointestinal Transit; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Intestine, Small; Male; Myoelectric Complex, Migrating; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Somatostatin | 1998 |
Changes in the concentrations of glucagon-like peptide-1(7-36)amide and gastric inhibitory polypeptide during the lactation cycle in goats.
Topics: Animals; Blood Glucose; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Goats; Insulin; Lactation; Peptide Fragments; Pregnancy; Time Factors | 1998 |
Peptide YY, glucagon-like peptide-1, and neurotensin responses to luminal factors in the isolated vascularly perfused rat ileum.
Topics: Animal Nutritional Physiological Phenomena; Animals; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Ileum; In Vitro Techniques; Male; Neurotensin; Peptide Fragments; Peptide YY; Perfusion; Protein Precursors; Rats; Rats, Wistar; Taurocholic Acid | 1998 |
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Androstadienes; Animals; Cell Line; Chromones; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Morpholines; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Proteins; Pyrrolidinones; Rats; Rolipram; Signal Transduction; Wortmannin | 1998 |
Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem.
Topics: Animals; Brain Stem; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Guinea Pigs; Infusions, Parenteral; Injections, Intraperitoneal; Injections, Intraventricular; Insulin; Insulin Secretion; Insulinoma; Lithium Chloride; Male; Neurons; Peptide Fragments; Proto-Oncogene Proteins c-fos; Rats; Rats, Long-Evans; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured | 1998 |
GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cell Line; Cloning, Molecular; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycogen; Glycolysis; Insulin; Kinetics; Muscle, Skeletal; Pancreas; Peptide Fragments; Protein Precursors; Rats; Receptors, Glucagon; Recombinant Proteins; Transfection; Venoms | 1998 |
Glucose and glucoincretin peptides synergize to induce c-fos, c-jun, junB, zif-268, and nur-77 gene expression in pancreatic beta(INS-1) cells.
Topics: Animals; Cell Line; Cyclic AMP; DNA-Binding Proteins; Drug Synergism; Early Growth Response Protein 1; Gastric Inhibitory Polypeptide; Gene Expression Regulation; Genes, fos; Genes, Immediate-Early; Genes, jun; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Immediate-Early Proteins; Islets of Langerhans; Neuropeptides; Nifedipine; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Recombinant Proteins; Tetradecanoylphorbol Acetate; Thionucleotides; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Zinc Fingers | 1998 |
Mutations in genes encoding extracellular matrix proteins suppress the emb-5 gastrulation defect in Caenorhabditis elegans.
Topics: Alleles; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Division; Collagen; Embryo, Nonmammalian; Extracellular Matrix Proteins; Gastrula; Gene Expression Regulation, Developmental; Genes; Genes, Suppressor; Genotype; Glucagon; Glucagon-Like Peptide 1; Helminth Proteins; Molecular Chaperones; Mutation; Peptide Fragments; Phenotype; Protein Precursors; Proteoglycans; Temperature; Transcription Factors | 1998 |
GLP-1 receptors in golden Syrian hamster islets: identification and functional characterization.
Topics: Animals; Blotting, Northern; Blotting, Western; Cricetinae; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulin; Islets of Langerhans; Mesocricetus; Peptide Fragments; Peptides; Rats; Receptors, Glucagon | 1998 |
Cushing's syndrome due to a gastric inhibitory polypeptide-dependent adrenal adenoma: insights into hormonal control of adrenocortical tumorigenesis.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocorticotropic Hormone; Adult; Calcium-Calmodulin-Dependent Protein Kinases; Cushing Syndrome; DNA; Female; Gastric Inhibitory Polypeptide; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Humans; Hydrocortisone; Peptide Fragments; Polymerase Chain Reaction; Protein Precursors; Receptors, Corticotropin; Receptors, Gastrointestinal Hormone; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Effects of glucagon-like peptide-1 (7-36)amide on insulin stimulated rat skeletal muscle glucose transport.
Topics: Animals; Biological Transport; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Male; Muscle, Skeletal; Peptide Fragments; Rats; Rats, Wistar | 1998 |
Intracerebroventricular glucagon-like peptide-1 (7-36) amide inhibits sham feeding in rats without eliciting satiety.
Topics: Animals; Dietary Sucrose; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intraventricular; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Satiety Response | 1998 |
Glucagon-like peptide-1 (7-36) amide administered into the third cerebroventricle inhibits water intake in rats.
Topics: Animals; Avoidance Learning; Cerebral Ventricles; Drinking; Eating; Glucagon; Glucagon-Like Peptide 1; Injections, Intraventricular; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Taste; Water Deprivation | 1998 |
The effect of glucose and glucagon-like peptide-1 stimulation on insulin release in the perfused pancreas in a non-insulin-dependent diabetes mellitus animal model.
Topics: Animals; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Male; Obesity; Pancreas; Peptide Fragments; Perfusion; Protein Precursors; Rats; Sex Factors | 1998 |
Regulation of glucagon-like peptide-1 synthesis and secretion in the GLUTag enteroendocrine cell line.
Topics: Animals; Carbachol; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enteroendocrine Cells; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Mice; Peptide Fragments; Protein Kinase C; Protein Precursors; Tetradecanoylphorbol Acetate | 1998 |
Effects of various N-terminal fragments of glucagon-like peptide-1(7-36) on food intake in the neonatal chick.
Topics: Amino Acid Sequence; Analysis of Variance; Animals; Animals, Newborn; Chickens; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intraventricular; Male; Molecular Sequence Data; Peptide Fragments; Sequence Homology, Amino Acid | 1998 |
Fermentable dietary fiber increases GLP-1 secretion and improves glucose homeostasis despite increased intestinal glucose transport capacity in healthy dogs.
Topics: Animals; Area Under Curve; Body Weight; Dietary Fiber; Dogs; Fermentation; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Ileum; Insulin; Microvilli; Monosaccharide Transport Proteins; Peptide Fragments; Proglucagon; Protein Precursors; RNA, Messenger | 1998 |
Contribution of a PS1-like element to the tissue- and cell-specific expression of the human GLP-1 receptor gene.
Topics: Animals; Base Sequence; Cell Line; Cell Nucleus; Cloning, Molecular; Cricetinae; Enhancer Elements, Genetic; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagonoma; Humans; Insulinoma; Islets of Langerhans; Molecular Sequence Data; Mutagenesis, Site-Directed; Organ Specificity; Pancreatic Neoplasms; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Receptors, Glucagon; Recombinant Proteins; Sequence Deletion; Sequence Homology, Nucleic Acid; Simian virus 40; Transfection; Tumor Cells, Cultured | 1998 |
High-level expression of the GLP-I receptor results in receptor desensitization.
Topics: Animals; Cells, Cultured; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Signal Transduction; Transfection | 1998 |
Glucagon-like peptide-1 retards gastric emptying and small bowel transit in the rat: effect mediated through central or enteric nervous mechanisms.
Topics: Acetylcholine; Animals; Blood Glucose; Central Nervous System; Electric Stimulation; Enteric Nervous System; Gastric Emptying; Gastrointestinal Transit; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Intestine, Small; Male; Muscle Contraction; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 1998 |
Functional interactions between melanin-concentrating hormone, neuropeptide Y, and anorectic neuropeptides in the rat hypothalamus.
Topics: alpha-MSH; Animals; Appetite Depressants; Appetite Stimulants; Drug Interactions; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypothalamic Hormones; Hypothalamus; Injections, Intraventricular; Kinetics; Male; Melanins; Neuropeptide Y; Neurotensin; Peptide Fragments; Pituitary Hormones; Rats; Rats, Sprague-Dawley | 1998 |
Exaggerated secretion of glucagon-like peptide-1 (GLP-1) could cause reactive hypoglycaemia.
Topics: Adult; Blood Glucose; C-Peptide; Dumping Syndrome; Female; Gastrectomy; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemia; Kinetics; Male; Peptide Fragments; Protein Precursors | 1998 |
Glycation of glucagon-like peptide-1(7-36)amide: characterization and impaired action on rat insulin secreting cells.
Topics: Amino Acid Sequence; Animals; Antibody Specificity; Cell Line; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycosylation; Insulin; Insulin Secretion; Intestine, Small; Islets of Langerhans; Mice; Molecular Sequence Data; Peptide Fragments; Radioimmunoassay; Rats; Sequence Analysis; Structure-Activity Relationship | 1998 |
Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: implications for basal intracellular cyclic adenosine 3',5'-monophosphate levels and beta-cell glucose competence.
Topics: Animals; Blotting, Northern; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Islets of Langerhans; Ligands; Mice; Peptide Fragments; Proglucagon; Protein Precursors; Receptors, Glucagon; RNA | 1998 |
A synthetic glucagon-like peptide-1 analog with improved plasma stability.
Topics: Animals; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Humans; Insulin; Insulin Secretion; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Time Factors; Tumor Cells, Cultured | 1998 |
Association of leptin receptor (OB-Rb), NPY and GLP-1 gene expression in the ovine and murine brainstem.
Topics: Animals; Base Sequence; Brain Stem; Carrier Proteins; DNA Primers; Feedback; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Hypothalamus; In Situ Hybridization; Male; Mice; Neuropeptide Y; Peptide Fragments; Protein Precursors; Receptors, Cell Surface; Receptors, Leptin; RNA, Messenger; Sheep; Signal Transduction; Species Specificity; Tissue Distribution | 1998 |
Amidated and non-amidated glucagon-like peptide-1 (GLP-1): non-pancreatic effects (cephalic phase acid secretion) and stability in plasma in humans.
Topics: Adult; Bacitracin; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Male; Middle Aged; Oligopeptides; Peptide Fragments; Protein Precursors; Stomach | 1998 |
Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow.
Topics: Animals; Bicarbonates; Blood Glucose; Gastric Acid; Gastrins; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Islets of Langerhans; Muscle Contraction; Muscle, Smooth; Neurotransmitter Agents; Pancreas; Pancreatic Juice; Pancreatic Polypeptide; Parasympathetic Nervous System; Peptide Fragments; Protein Precursors; Stomach; Swine; Vagotomy; Vagus Nerve | 1998 |
Effects of neurotransmitters, gut hormones, and inflammatory mediators on mucus discharge in rat colon.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Atropine; Bethanechol; Bombesin; Calcitonin Gene-Related Peptide; Colon; Enteric Nervous System; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Inflammation; Interleukin-1; Intestinal Mucosa; Isoproterenol; Lasalocid; Male; Mucus; Neurotransmitter Agents; Nitroprusside; Peptide Fragments; Peptide YY; Protein Precursors; Rats; Rats, Wistar; Serotonin; Tetrodotoxin; Vasoactive Intestinal Peptide | 1998 |
The ageing entero-insular axis.
Topics: Acetaminophen; Adult; Aged; Aging; Blood Glucose; Body Mass Index; Body Weight; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Intolerance; Humans; Insulin; Insulin Secretion; Peptide Fragments; Postmenopause; Premenopause; Risk Factors | 1998 |
Examination of somatostatin involvement in the inhibitory action of GIP, GLP-1, amylin and adrenomedullin on gastric acid release using a new SRIF antagonist analogue.
Topics: Adrenomedullin; Amyloid; Animals; Dose-Response Relationship, Drug; Gastric Acid; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Islet Amyloid Polypeptide; Male; Peptide Fragments; Peptides; Protein Precursors; Rats; Receptors, Somatostatin; Somatostatin | 1998 |
Inhibition of glucose stimulated insulin secretion by neuropeptide Y is mediated via the Y1 receptor and inhibition of adenylyl cyclase in RIN 5AH rat insulinoma cells.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Blotting, Northern; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Iodine Radioisotopes; Isoproterenol; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Peptide YY; Protein Precursors; Rats; Receptors, Neuropeptide Y; Swine; Tumor Cells, Cultured | 1998 |
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Capsules; Cell Division; Cell Separation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Insulinoma; Pancreas, Artificial; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Time Factors; Tumor Cells, Cultured | 1997 |
Coexpression of glucagon-like peptide-1 (GLP-1) receptor, vasopressin, and oxytocin mRNAs in neurons of the rat hypothalamic supraoptic and paraventricular nuclei: effect of GLP-1(7-36)amide on vasopressin and oxytocin release.
Topics: Animals; Brain Chemistry; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Situ Hybridization; Male; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pituitary Gland; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Supraoptic Nucleus; Vasopressins | 1999 |
Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat.
Topics: Animals; Body Weight; Energy Intake; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intraventricular; Male; Neurotransmitter Agents; Peptide Fragments; Rats; Rats, Wistar | 1999 |
Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39.
Topics: Cytokines; Eating; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors | 1999 |
Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice.
Topics: Animals; Cell Line; DNA-Binding Proteins; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Hyperinsulinism; Insulin; Islets of Langerhans; Leptin; Mice; Mice, Obese; Nuclear Proteins; Peptide Fragments; Proinsulin; Promoter Regions, Genetic; Protein Precursors; Proteins; Rats; Recombinant Proteins; RNA, Messenger; Transcription, Genetic | 1999 |
Structure-function analysis of a series of glucagon-like peptide-1 analogs.
Topics: Amino Acid Sequence; Cell Line; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Peptides; Protein Conformation; Protein Precursors; Structure-Activity Relationship | 1998 |
Oral triacylglycerols regulate plasma glucagon-like peptide-1(7-36) and insulin levels in normal and especially in obese rats.
Topics: Administration, Oral; Animals; Blood Glucose; Corn Oil; Fatty Acids; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Glycerol; Insulin; Intubation, Gastrointestinal; Obesity; Peptide Fragments; Rats; Rats, Wistar; Reference Values; Triglycerides; Veins | 1999 |
Immunoblockade of endogenous glucagon-like peptide-1 by monoclonal antibodies in conscious rats: effect on the insulin response to intragastric glucose.
Topics: Animals; Antibodies, Monoclonal; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Male; Mice; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar | 1999 |
Glucagon-like peptide-1 has no insulin-like effects in insulin-dependent diabetic dogs maintained normoglycemic and normoinsulinemic.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 1; Dogs; Female; Glucagon; Glucagon-Like Peptide 1; Insulin; Male; Peptide Fragments; Protein Precursors | 1999 |
Insulin and intracellular calcium responsiveness to glucagon-like peptide-1 and pituitary adenylate cyclase-activating peptide by dispersed adult porcine islet cells.
Topics: Animals; Calcium; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Intracellular Membranes; Islets of Langerhans; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Swine | 1999 |
Initiation of increased pancreatic islet growth in young normoglycemic mice (Umeå +/?).
Topics: 5-Hydroxytryptophan; Animals; Blood Glucose; C-Peptide; Cell Division; Culture Techniques; Glucagon; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Islets of Langerhans; Mice; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Vasoactive Intestinal Peptide | 1999 |
Miniglucagon: a local regulator of islet physiology.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Calcium Channels, L-Type; Cell Line; Cell Membrane; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glyburide; Homeostasis; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Membrane Potentials; Peptide Fragments; Peptides | 1998 |
PACAP and GLP-1 protect islet beta-cells against Ca2+ toxicity induced by high K+.
Topics: Animals; Arginine; Calcium; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Neuropeptides; Nifedipine; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Potassium Chloride; Protein Precursors; Rats; Rats, Wistar; Tolbutamide | 1998 |
A target cell to oxyntomodulin and glicentin: the antral smooth muscle cell.
Topics: Animals; Cell Membrane Permeability; Cyclic AMP; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Muscle Contraction; Muscle, Smooth; Oxyntomodulin; Peptide Fragments; Peptides; Protein Precursors; Pyloric Antrum; Rabbits; Stomach; Thionucleotides; Vasoactive Intestinal Peptide | 1998 |
Intestinal nutrient-gene interaction: the effect of feed deprivation and refeeding on cholecystokinin and proglucagon gene expression.
Topics: Animals; Autoradiography; Blotting, Northern; Cattle; Cholecystokinin; Duodenum; Eating; Female; Food Deprivation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Ileum; Peptide Fragments; Proglucagon; Protein Precursors; RNA, Messenger; Rumen | 1998 |
The relative contribution of insulin secretory capacity, insulin action, and incretins to metabolic control after islet transplantation in dogs.
Topics: Animals; Dogs; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Peptide Fragments | 1999 |
Glucagon-like peptide-1 activates the adenylyl cyclase system in rockfish enterocytes and brain membranes.
Topics: Adenylyl Cyclases; Animals; Brain; Cyclic AMP; Enzyme Activation; Fishes; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Intestinal Mucosa; Intestines; Liver; Mammals; Membranes; Peptide Fragments; Protein Precursors; Signal Transduction | 1998 |
Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones.
Topics: Amino Acid Sequence; Animals; Black Widow Spider; Calcium Signaling; Cells, Cultured; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Molecular Mimicry; Molecular Sequence Data; Neurotoxins; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Sequence Homology, Amino Acid; Spider Venoms; Venoms | 1998 |
Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus.
Topics: Calcium; Carrier Proteins; Cells, Cultured; Diabetes Mellitus; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Obesity; Peptide Fragments; Potassium Channels; Proinsulin; Protein Precursors; Proteins; Receptors, Cell Surface; Receptors, Leptin; RNA, Messenger | 1999 |
Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1.
Topics: Animals; Area Under Curve; Blood Glucose; Cells, Cultured; Diet; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Protein Precursors | 1999 |
Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations.
Topics: Animals; Blood Glucose; Body Weight; Carrier Proteins; Crosses, Genetic; Cyclic AMP; Diabetes Mellitus, Type 2; Drug Administration Schedule; Energy Intake; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Insulin; Islets of Langerhans; Lizards; Mice; Mice, Inbred C57BL; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Leptin; Venoms | 1999 |
Glucagonlike peptide-1 (GLP-1) participation in ileal brake induced by intraluminal peptones in rat.
Topics: Adrenergic alpha-Antagonists; Animals; Duodenum; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Ileum; Jejunum; Male; Ovalbumin; Peptide Fragments; Peptones; Phentolamine; Propranolol; Protein Hydrolysates; Protein Precursors; Pyloric Antrum; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 1999 |
Inhibition of carbohydrate-mediated glucagon-like peptide-1 (7-36)amide secretion by circulating non-esterified fatty acids.
Topics: Adult; Analysis of Variance; Area Under Curve; Case-Control Studies; Dietary Carbohydrates; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Heparin; Humans; Insulin; Models, Biological; Neurotransmitter Agents; Obesity; Peptide Fragments; Postprandial Period; Pyrazines; Triglycerides | 1999 |
The effect of circulating non-esterified fatty acids on the entero-insular axis.
Topics: Adult; Blood Glucose; Dietary Carbohydrates; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Heparin; Humans; Insulin; Intestines; Islets of Langerhans; Obesity; Peptide Fragments; Protein Precursors; Pyrazines | 1999 |
Improved glucose tolerance in rats treated with the dipeptidyl peptidase IV (CD26) inhibitor Ile-thiazolidide.
Topics: Animals; Colorimetry; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Insulin; Isoleucine; Male; Peptide Fragments; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Thiazoles | 1999 |
Euglycaemic hyperinsulinaemia does not affect gastric emptying in type I and type II diabetes mellitus.
Topics: Adult; Amyloid; Blood Glucose; C-Peptide; Cholecystokinin; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glycated Hemoglobin; Humans; Hyperinsulinism; Hypoglycemic Agents; Infusions, Intravenous; Insulin; Islet Amyloid Polypeptide; Male; Peptide Fragments; Protein Precursors | 1999 |
Role of GLP-1 in meal-taking.
Topics: Animals; Appetite Depressants; Eating; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Peptide Fragments; Protein Precursors; Rats | 1999 |
Role of the vagus nerve in mediating proximal nutrient-induced glucagon-like peptide-1 secretion.
Topics: Animals; Blood Glucose; Corn Oil; Duodenum; Electric Stimulation; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Kinetics; Male; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Vagotomy; Vagus Nerve | 1999 |
Biological activity of GLP-1-analogues with N-terminal modifications.
Topics: Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Iodine Radioisotopes; Peptide Fragments; Protein Precursors; Structure-Activity Relationship | 1999 |
Glucose-dependent stimulatory effect of glucagon-like peptide 1(7-36) amide on the electrical activity of pancreatic beta-cells recorded in vivo.
Topics: Animals; Blood Glucose; Electrophysiology; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Osmolar Concentration; Peptide Fragments; Tolbutamide | 1999 |
Insulin secretion and intestinal peptides during lactation in sheep.
Topics: Animals; Blood Glucose; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Lactation; Peptide Fragments; Sheep; Somatostatin; Somatostatin-28 | 1999 |
The influence of the colon on postprandial glucagon-like peptide 1 (7-36) amide concentration in man.
Topics: Analysis of Variance; Blood Glucose; Case-Control Studies; Colitis, Ulcerative; Colon; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Ileostomy; Insulin; Male; Middle Aged; Neurotransmitter Agents; Peptide Fragments; Postprandial Period | 1999 |
Miniglucagon (glucagon 19-29), a potent and efficient inhibitor of secretagogue-induced insulin release through a Ca2+ pathway.
Topics: Calcium; Calcium Channels; Cell Line; Cholinergic Agonists; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Antagonists; Insulin Secretion; Ion Transport; Islets of Langerhans; Membrane Potentials; Peptide Fragments; Peptides; Pertussis Toxin; Virulence Factors, Bordetella | 1999 |
Effect of large bowel fermentation on insulin, glucose, free fatty acids, and glucagon-like peptide 1 (7-36) amide in patients with coronary heart disease.
Topics: Aged; Blood Glucose; Coronary Disease; Fatty Acids, Nonesterified; Fermentation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Intestinal Absorption; Intestine, Large; Lactulose; Male; Middle Aged; Peptide Fragments; Risk Factors | 1999 |
Elevated plasma levels of glucagon-like peptide-1 after oral glucose ingestion in patients with pancreatic diabetes.
Topics: C-Peptide; Case-Control Studies; Chronic Disease; Diabetes Mellitus; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Male; Middle Aged; Pancreatitis; Peptide Fragments; Protein Precursors; Time Factors | 1999 |
Linkage analysis of candidate obesity genes among the Mexican-American population of Starr County, Texas.
Topics: Adult; Anthropometry; Carrier Proteins; Case-Control Studies; Chromosome Mapping; Female; Gene Frequency; Genetic Variation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Ion Channels; Leptin; Male; Membrane Proteins; Mexican Americans; Microsatellite Repeats; Middle Aged; Mitochondrial Proteins; Neuropeptide Y; Obesity; Pedigree; Peptide Fragments; Protein Precursors; Proteins; Receptors, Cell Surface; Receptors, Glucagon; Receptors, Leptin; Receptors, Neuropeptide Y; Texas; Uncoupling Protein 1 | 1999 |
Peptides as drugs.
Topics: Anti-Bacterial Agents; Glucagon; Glucagon-Like Peptide 1; Growth Substances; Humans; Insulin; Interferons; Leptin; Obesity; Peptide Fragments; Peptides; Protein Precursors; Proteins | 1999 |
cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37).
Topics: Animals; Boron Compounds; Caffeine; Calcium; Cyclic AMP; Fluorescent Dyes; Glucagon; Glucagon-Like Peptide 1; Humans; Islets of Langerhans; Mice; Mice, Inbred C57BL; Peptide Fragments; Polymerase Chain Reaction; Protein Precursors; Rats; RNA, Messenger; Ryanodine; Ryanodine Receptor Calcium Release Channel; Signal Transduction; Tumor Cells, Cultured | 1999 |
Gastrointestinal responses to a panel of lectins in rats maintained on total parenteral nutrition.
Topics: Animals; Cell Division; Cholecystokinin; Colon; Digestive System; Digestive System Physiological Phenomena; Gastrins; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Intestine, Small; Lectins; Male; Organ Size; Pancreas; Parenteral Nutrition, Total; Peanut Agglutinin; Peptide Fragments; Phytohemagglutinins; Protein Precursors; Rats; Rats, Sprague-Dawley; Stomach | 1999 |
Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta).
Topics: Animals; Blood Glucose; Diabetes Mellitus; Dose-Response Relationship, Drug; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Kinetics; Macaca mulatta; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Zucker; Sequence Homology; Venoms | 1999 |
Glucagon-like peptide 1 increases insulin sensitivity in depancreatized dogs.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dogs; Fatty Acids, Nonesterified; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Clamp Technique; Glycerol; Insulin; Insulin Secretion; Kinetics; Male; Pancreatectomy; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Reverse Transcriptase Polymerase Chain Reaction; Somatostatin | 1999 |
Inhibition of insulin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) secretion by octreotide has no effect on post-heparin plasma lipoprotein lipase activity.
Topics: Adult; Blood Glucose; Dietary Carbohydrates; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Heparin; Hormones; Humans; Insulin; Kinetics; Lipoprotein Lipase; Octreotide; Peptide Fragments; Protein Precursors | 1999 |
Effect of GIP and GLP-1 antagonists on insulin release in the rat.
Topics: Absorption; Animals; Blood Glucose; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Gastrointestinal Hormone | 1999 |
Effects of glucagon and glucagon-like peptide-1 on glucocorticoid secretion of dispersed rat adrenocortical cells.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Bucladesine; Colforsin; Corticosterone; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucocorticoids; In Vitro Techniques; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Steroids | 1999 |
Insulin and proglucagon-derived peptides from the horned frog, Ceratophrys ornata (Anura:Leptodactylidae).
Topics: Amino Acid Sequence; Animals; Anura; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Molecular Sequence Data; Pancreas; Peptide Fragments; Protein Precursors; Sequence Homology; Species Specificity | 1999 |
Properties of native and in vitro glycosylated forms of the glucagon-like peptide-1 receptor antagonist exendin(9-39).
Topics: Animals; Chlorocebus aethiops; Cyclic AMP; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glycosylation; Humans; In Vitro Techniques; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 1999 |
In vivo dynamic distribution of 131I-glucagon-like peptide-1 (7-36) amide in the rat studied by gamma camera.
Topics: Animals; Brain; Gamma Cameras; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Iodine Radioisotopes; Male; Metabolic Clearance Rate; Peptide Fragments; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1999 |
The European Association for the Study of Diabetes Annual Meeting, 1998. Treatment of type 2 diabetes and the pathogenesis of complications.
Topics: Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin Resistance; Obesity; Peptide Fragments; Protein Precursors | 1999 |
Biochemical basis of oligofructose-induced hypolipidemia in animal models.
Topics: Animals; Blood Glucose; Dietary Fiber; Fatty Acids; Gene Expression Regulation, Enzymologic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Lipoproteins; Liver; Male; Neurotransmitter Agents; Oligosaccharides; Peptide Fragments; Rats; Rats, Wistar; Triglycerides | 1999 |
Comparison of the postprandial release of peptide YY and proglucagon-derived peptides in the rat.
Topics: Animals; Fatty Acids; Food; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hexamethonium; Kinetics; Male; Oleic Acid; Oxyntomodulin; Peptide Fragments; Peptide YY; Proglucagon; Protein Precursors; Rats; Rats, Wistar | 1999 |
Comparison of the effect of native glucagon-like peptide 1 and dipeptidyl peptidase IV-resistant analogues on insulin release from rat pancreatic islets.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar | 1999 |
Stimulatory effect of beta-adrenergic agonists on ileal L cell secretion and modulation by alpha-adrenergic activation.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Clonidine; Epinephrine; Glucagon; Glucagon-Like Peptide 1; Isoproterenol; Peptide Fragments; Peptide YY; Phenylephrine; Prazosin; Protein Precursors; Rats; Rats, Wistar | 1999 |
Effect of gastric inhibitory polypeptide on bovine fat metabolism.
Topics: Adipose Tissue; Animals; Cattle; Diet; Eating; Fatty Acids, Nonesterified; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Infusions, Intravenous; Insulin; Lipid Metabolism; Lipids; Lipolysis; Palmitic Acid; Peptide Fragments; Plants, Edible; Protein Precursors; Urea | 1999 |
Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells.
Topics: Androstadienes; Animals; Chromones; DNA; DNA-Binding Proteins; Duodenum; Enzyme Activation; Enzyme Inhibitors; Genes, Homeobox; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Islets of Langerhans; Morpholines; Nifedipine; Pancreas; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Potassium Chloride; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Tumor Cells, Cultured; Wortmannin | 1999 |
Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Barium; Calcium Channel Agonists; Cell Line; Cyclic AMP; Electric Conductivity; Gene Deletion; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Mutagenesis; Peptide Fragments; Protein Precursors; Rats; Receptors, Glucagon; Structure-Activity Relationship; Transfection | 1999 |
The incretins--outdated terminology in man?
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Insulin Secretion; Papio; Peptide Fragments; Protein Precursors | 1999 |
Glucagon-like peptide 1 elevates cytosolic calcium in pancreatic beta-cells independently of protein kinase A.
Topics: Animals; Calcium; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytosol; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Male; Mice; Mice, Inbred DBA; Osmolar Concentration; Peptide Fragments; Protein Kinase Inhibitors; Protein Precursors; Staurosporine | 1999 |
Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects.
Topics: Adult; Appetite; Blood Glucose; Dietary Carbohydrates; Fructose; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hunger; Insulin; Male; Peptide Fragments; Protein Precursors; Satiety Response | 1999 |
Functional studies of a glucagon receptor isolated from frog Rana tigrina rugulosa: implications on the molecular evolution of glucagon receptors in vertebrates.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; COS Cells; Cricetinae; Cyclic AMP; Evolution, Molecular; Exenatide; Glucagon; Glucagon-Like Peptide 1; Humans; Inhibitory Concentration 50; Molecular Sequence Data; Neuropeptides; Peptide Fragments; Peptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Ranidae; Receptors, Glucagon; Recombinant Proteins; Secretin; Sequence Homology, Amino Acid; Species Specificity; Vasoactive Intestinal Peptide; Venoms; Vertebrates; Zebrafish | 1999 |
Essential requirement for Pax6 in control of enteroendocrine proglucagon gene transcription.
Topics: Animals; Animals, Newborn; Blotting, Northern; Cell Line; DNA-Binding Proteins; Enteroendocrine Cells; Eye Proteins; Female; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Homeodomain Proteins; Immunohistochemistry; Intestinal Mucosa; Intestines; Islets of Langerhans; Luciferases; Male; Mice; Mice, Mutant Strains; Mutation; Paired Box Transcription Factors; PAX6 Transcription Factor; Peptide Fragments; Peptides; Proglucagon; Promoter Regions, Genetic; Protein Binding; Protein Precursors; Recombinant Fusion Proteins; Repressor Proteins; RNA, Messenger; Tissue Distribution; Transcription, Genetic | 1999 |
Proteolytic cleavage of glucagon-like peptide-1 by pancreatic beta cells and by fetal calf serum analyzed by mass spectrometry.
Topics: Amino Acid Sequence; Animals; Blood; Cattle; Glucagon; Glucagon-Like Peptide 1; Hydrolysis; Islets of Langerhans; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Rats; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tumor Cells, Cultured | 1999 |
GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans.
Topics: Adult; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Peptide Fragments; Peptide YY; Protein Precursors | 1999 |
Tachykinins stimulate release of peptide hormones (glucagon-like peptide-1) and paracrine (somatostatin) and neurotransmitter (vasoactive intestinal polypeptide) from porcine ileum through NK-1 receptors.
Topics: Animals; Cholinergic Fibers; Glucagon; Glucagon-Like Peptide 1; Ileum; Neurokinin A; Neurons; Peptide Fragments; Protein Precursors; Receptors, Neurokinin-1; Sensory Receptor Cells; Somatostatin; Stimulation, Chemical; Substance P; Swine; Vasoactive Intestinal Peptide | 1999 |
Inhibitory effect of enterostatin on the beta cell response to digestive insulinotropic peptides.
Topics: Animals; Carbachol; Cholecystokinin; Cholinergic Agonists; Colipases; Enzyme Precursors; Fasting; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar | 1999 |
[Inhibition of incretin degradation--a new therapy principle for treatment of type 2 diabetes?].
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Isoleucine; Peptide Fragments; Rats; Rats, Zucker; Thiazoles | 1999 |
Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; RNA, Messenger; Trans-Activators; Tumor Cells, Cultured | 1999 |
Glucagon-like peptide-1 modulates neuronal activity in the rat's hippocampus.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glutamic Acid; Glutamine; Hippocampus; Injections, Intraventricular; Male; Neurons; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Stimulation, Chemical; Ventromedial Hypothalamic Nucleus | 1999 |
Importance of colonic bacterial fermentation in short bowel patients: small intestinal malabsorption of easily digestible carbohydrate.
Topics: Adult; Aged; Bacteria; Carbohydrate Metabolism; Colon; Digestion; Female; Fermentation; Glucagon; Glucagon-Like Peptide 1; Humans; Intestinal Absorption; Intestine, Small; Middle Aged; Peptide Fragments; Peptide YY; Protein Precursors; Short Bowel Syndrome | 1999 |
Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells).
Topics: Animals; Calcium; Colforsin; Cyclic AMP; Cytoplasm; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Leptin; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Kinase C; Protein Precursors; Rats; Tumor Cells, Cultured | 1999 |
Identification of glucagon-like peptide-2 (GLP-2)-activated signaling pathways in baby hamster kidney fibroblasts expressing the rat GLP-2 receptor.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Fibroblasts; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Kidney; Luciferases; Mitogen-Activated Protein Kinases; Peptide Fragments; Peptides; Phosphorylation; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Receptors, Glucagon; Recombinant Proteins; Signal Transduction; Transcription Factor AP-1; Transcription, Genetic; Transfection | 1999 |
mRNA levels of dipeptidyl peptidase IV decrease during intestinal adaptation.
Topics: Adaptation, Physiological; Animals; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Intestines; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1999 |
Glucagon-like peptide-1 does not mediate amylase release from AR42J cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amylases; Animals; Base Sequence; Calcium Signaling; Cell Line; Cholecystokinin; Cyclic AMP; DNA Primers; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Pancreas; Peptide Fragments; Phosphorylation; Protein Precursors; Rats; Receptors, Glucagon; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 1999 |
Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine.
Topics: Animals; Capillaries; Chromatography, High Pressure Liquid; Dipeptidyl Peptidase 4; Endothelium, Vascular; Epithelium; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histocytochemistry; Immunohistochemistry; Intestinal Mucosa; Microvilli; Peptide Fragments; Peptides; Swine | 1999 |
Endogenous GLP-1 modulates hippocampal activity in beta-amyloid protein-treated rats.
Topics: Amyloid beta-Peptides; Animals; Avoidance Learning; Brain Chemistry; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Lateral Ventricles; Male; Memory Disorders; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon | 1999 |
Twenty-four-hour insulin secretion rates, circulating concentrations of fuel substrates and gut incretin hormones in healthy offspring of Type II (non-insulin-dependent) diabetic parents: evidence of several aberrations.
Topics: Adult; Blood; Blood Glucose; C-Peptide; Circadian Rhythm; Diabetes Mellitus, Type 2; Eating; Energy Metabolism; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Intestinal Mucosa; Male; Middle Aged; Peptide Fragments; Proinsulin; Reference Values | 1999 |
Inhibition of dipeptidyl peptidase IV with NVP-DPP728 increases plasma GLP-1 (7-36 amide) concentrations and improves oral glucose tolerance in obese Zucker rats.
Topics: Animals; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Male; Nitriles; Obesity; Osmolar Concentration; Peptide Fragments; Pyrrolidines; Rats; Rats, Zucker; Reference Values | 1999 |
Lamprey proglucagon and the origin of glucagon-like peptides.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA, Complementary; Evolution, Molecular; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Lampreys; Molecular Sequence Data; Peptides; Proglucagon; Protein Precursors; RNA, Messenger; Sequence Homology, Amino Acid | 1999 |
A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia.
Topics: Animals; Anorexia; Brain; Dose-Response Relationship, Drug; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intraventricular; Lithium Chloride; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 1999 |
Neural contribution to the effect of glucagon-like peptide-1-(7-36) amide on arterial blood pressure in rats.
Topics: Animals; Blood Pressure; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Heart Rate; Humans; Injections, Intravenous; Injections, Intraventricular; Male; Neurotransmitter Agents; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Vagotomy; Vagus Nerve | 1999 |
Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.
Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Islets of Langerhans; Male; Pancreatectomy; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Venoms | 1999 |
Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.
Topics: Adenylyl Cyclases; Amylases; Animals; Cell Cycle; Cell Differentiation; Cholecystokinin; Dexamethasone; Exenatide; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Insulin; Kinetics; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Precursors; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Venoms | 1999 |
Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice.
Topics: Animals; Blood Glucose; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Insulin Secretion; Mice; Mice, Inbred Strains; Peptide Fragments; Peptides; Protein Precursors | 1999 |
Insulin secretion defects in liver cirrhosis can be reversed by glucagon-like peptide-1.
Topics: Analysis of Variance; Animals; Carbon Tetrachloride; Culture Techniques; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans; Liver Cirrhosis, Experimental; Liver Function Tests; Male; Peptide Fragments; Phenobarbital; Protein Precursors; Rats; Rats, Inbred Lew | 2000 |
Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice.
Topics: Administration, Oral; Animals; Diabetes Mellitus, Type 2; Dietary Fats; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Intolerance; Glucose Tolerance Test; Homeostasis; Injections, Intraperitoneal; Insulin; Insulin Resistance; Insulin Secretion; Intestines; Islets of Langerhans; Mice; Mice, Knockout; Models, Biological; Peptide Fragments; Protein Precursors; Receptors, Gastrointestinal Hormone | 1999 |
Effects of substitution of N-terminal amino acid of glucagon-like peptide-1 (7-36) amide on food intake of the neonatal chick.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Animals, Newborn; Chickens; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histidine; Injections, Intraventricular; Male; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Structure-Activity Relationship; Tyrosine | 1999 |
Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain.
Topics: Animals; Brain Injuries; Gene Expression; Glial Fibrillary Acidic Protein; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; In Situ Hybridization; Male; Neuroglia; Peptide Fragments; Rats; Rats, Wistar; Receptors, Glucagon; RNA, Messenger; Wounds, Stab | 1999 |
The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride.
Topics: Angiotensins; Animals; Avoidance Learning; Cerebral Ventricles; Drinking Behavior; Energy Intake; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intraventricular; Kaolin; Lithium Chloride; Male; Peptide Fragments; Rats; Rats, Long-Evans; Receptors, Glucagon; Sodium, Dietary; Taste; Time Factors | 2000 |
GLP-1-analogues resistant to degradation by dipeptidyl-peptidase IV in vitro.
Topics: Animals; Binding, Competitive; Chromatography, High Pressure Liquid; Cyclic AMP; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Molecular Structure; Peptide Fragments; Protein Precursors; Rats; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Tumor Cells, Cultured | 2000 |
An osmotic stimulus-mediating glucagon-like peptide-1 (7-36 amide) (GLP-1) secretion in acarbose-induced sucrose malabsorption?
Topics: Acarbose; Adult; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Intestinal Absorption; Male; Middle Aged; Osmolar Concentration; Peptide Fragments; Sucrose | 2000 |
The cyclic AMP-protein kinase A pathway restrains islet phospholipase A(2) activation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Carbachol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Melitten; Peptide Fragments; Phospholipases A; Protein Precursors; Rats; Rats, Sprague-Dawley; Signal Transduction; Sincalide; Vasoactive Intestinal Peptide | 2000 |
Comparison of free solution capillary electrophoresis and size exclusion chromatography for quantitating non-covalent aggregation of an acylated peptide.
Topics: Acylation; Amino Acid Sequence; Chromatography, Gel; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Glucagon; Glucagon-Like Peptide 1; Light; Molecular Sequence Data; Peptide Fragments; Peptides; Pressure; Protein Precursors; Scattering, Radiation; Solutions; Solvents; Spectrophotometry, Ultraviolet | 1999 |
N-terminally modified glucagon-like peptide-1(7-36) amide exhibits resistance to enzymatic degradation while maintaining its antihyperglycaemic activity in vivo.
Topics: Animals; Blood Glucose; Chromatography, High Pressure Liquid; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Homeostasis; Humans; Hypoglycemic Agents; Insulin; Male; Peptide Fragments; Peptides; Rats; Rats, Wistar; Sorbitol | 2000 |
Effect of leptin on hypothalamic GLP-1 peptide and brain-stem pre-proglucagon mRNA.
Topics: Animals; Brain Stem; Glucagon; Glucagon-Like Peptide 1; Hypothalamus; Injections, Intraventricular; Leptin; Male; Peptide Fragments; Proglucagon; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; RNA, Messenger | 2000 |
Does the response of the intestinal epithelium to keratinocyte growth factor vary according to the method of administration?
Topics: Animals; Body Weight; Fibroblast Growth Factor 10; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Gastrins; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Growth Substances; Intestinal Mucosa; Male; Metaphase; Organ Size; Peptide Fragments; Peptide YY; Protein Precursors; Rats; Rats, Wistar | 2000 |
The hepatic vagal reception of intraportal GLP-1 is via receptor different from the pancreatic GLP-1 receptor.
Topics: Animals; Electrophysiology; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intravenous; Liver; Male; Neurons, Afferent; Pancreas; Peptide Fragments; Peptides; Portal Vein; Rats; Rats, Wistar; Receptors, Glucagon; Vagus Nerve; Venoms | 2000 |
Characterization of human and rat glucagon-like peptide-1 receptors in the neurointermediate lobe: lack of coupling to either stimulation or inhibition of adenylyl cyclase.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arginine Vasopressin; Autoradiography; Binding Sites; Cyclic AMP; Enzyme Activation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Male; Membranes; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon | 2000 |
Regulation of pancreatic PC1 and PC2 associated with increased glucagon-like peptide 1 in diabetic rats.
Topics: Animals; Aspartic Acid Endopeptidases; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; Insulin; Islets of Langerhans; Male; Pancreas; Peptide Fragments; Proinsulin; Proprotein Convertase 2; Proprotein Convertases; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Streptozocin; Subtilisins | 2000 |
GLP-1 and the gut.
Topics: Animals; Enteroendocrine Cells; Gastric Acid; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors | 2000 |
Effects of glucagon-like peptide-1(7-36)amide on antro-pyloro-duodenal motility in the interdigestive state and with duodenal lipid perfusion in humans.
Topics: Adult; Duodenum; Gastric Emptying; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Humans; Lipids; Male; Manometry; Peptide Fragments; Postprandial Period; Pressure; Protein Precursors; Pyloric Antrum; Time Factors | 2000 |
Peptidergic regulation of maturation of the stimulus-secretion coupling in fetal islet beta cells.
Topics: Animals; Chromogranin A; Culture Techniques; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Human Growth Hormone; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Octreotide; Pancreatic Hormones; Peptide Fragments; Peptides; Pregnancy; Protein Precursors; Rats; Rats, Wistar; Transforming Growth Factor alpha | 2000 |
Calcitonin gene-related peptide potently stimulates glucagon-like peptide-1 release in the isolated perfused rat ileum.
Topics: Animals; Atropine; Calcitonin Gene-Related Peptide; Female; Galanin; Glucagon; Glucagon-Like Peptide 1; Ileum; In Vitro Techniques; Kinetics; Peptide Fragments; Perfusion; Protein Precursors; Rats; Rats, Wistar | 2000 |
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration.
Topics: Acylation; Amino Acid Sequence; Animals; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Diabetes Mellitus, Type 2; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Kidney; Lysine; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Swine | 2000 |
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.
Topics: Animals; Blood Glucose; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Mice; Mice, Inbred C57BL; Peptide Fragments; Protein Precursors | 2000 |
Oxyntomodulin inhibits pancreatic secretion through the nervous system in rats.
Topics: Animals; Deoxyglucose; Drug Interactions; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Kinetics; Male; Oxyntomodulin; Pancreas; Peptide Fragments; Peptide YY; Protein Precursors; Rats; Rats, Wistar; Sincalide; Vagus Nerve | 2000 |
Cocaine- and amphetamine-regulated transcript, glucagon-like peptide-1 and corticotrophin releasing factor inhibit feeding via agouti-related protein independent pathways in the rat.
Topics: Agouti-Related Protein; alpha-MSH; Animals; Brain; Corticotropin-Releasing Hormone; Eating; Glucagon; Glucagon-Like Peptide 1; Intercellular Signaling Peptides and Proteins; Leptin; Male; Nerve Tissue Proteins; Peptide Fragments; Protein Precursors; Proteins; Rats; Rats, Wistar; Receptor, Melanocortin, Type 4; Receptors, Peptide | 2000 |
Lack of germline mutations in the preproglucagon gene region coding for glucagon-like peptide 1 in Type 2 diabetic (NIDDM) patients.
Topics: Aged; Amino Acid Sequence; Base Sequence; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Molecular Sequence Data; Mutation; Peptide Fragments; Proglucagon; Protein Precursors; Sequence Analysis, DNA | 2000 |
Somatostatin restrains the secretion of glucagon-like peptide-1 and -2 from isolated perfused porcine ileum.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Bombesin; Chromatography, Gel; Electric Stimulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Ileum; Peptide Fragments; Peptides; Phentolamine; Protein Precursors; Somatostatin; Swine | 2000 |
Evaluation of beta-cell secretory capacity using glucagon-like peptide 1.
Topics: Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Peptide Fragments; Postprandial Period; Protein Precursors; Reference Values; Time Factors | 2000 |
1,5-Anhydro-D-fructose increases glucose tolerance by increasing glucagon-like peptide-1 and insulin in mice.
Topics: Animals; Dose-Response Relationship, Drug; Fructose; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; In Vitro Techniques; Injections, Intravenous; Insulin; Insulin Secretion; Intubation, Gastrointestinal; Islets of Langerhans; Mice; Mice, Inbred Strains; Peptide Fragments; Protein Precursors; Time Factors | 2000 |
Proglucagon cDNAs from the leopard frog, Rana pipiens, encode two GLP-1-like peptides.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; DNA Primers; DNA, Complementary; Evolution, Molecular; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Intestinal Mucosa; Molecular Sequence Data; Pancreas; Peptide Fragments; Peptides; Phylogeny; Proglucagon; Protein Precursors; Rana pipiens; RNA, Messenger; Sequence Homology, Amino Acid | 2000 |
Glucagon-like peptide (GLP-1) is involved in the central modulation of fecal output in rats.
Topics: Animals; Brain; Corticotropin-Releasing Hormone; Defecation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Injections, Intraperitoneal; Injections, Intraventricular; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Restraint, Physical; Stress, Physiological | 2000 |
Peripheral versus central effects of glucagon-like peptide-1 receptor agonists on satiety and body weight loss in Zucker obese rats.
Topics: Amines; Animals; Appetite; Body Weight; Brain; Diabetes Mellitus; Drinking; Eating; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; In Situ Hybridization; Injections, Intraventricular; Injections, Subcutaneous; Male; Obesity; Peptide Fragments; Peptides; Rats; Rats, Wistar; Rats, Zucker; Receptors, Glucagon; RNA, Messenger; Venoms | 2000 |
Islet hormones from the African bullfrog Pyxicephalus adspersus (Anura:Ranidae): structural characterization and phylogenetic implications.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Insulin; Molecular Sequence Data; Pancreatic Hormones; Pancreatic Polypeptide; Peptide Fragments; Phylogeny; Protein Precursors; Ranidae; Sequence Homology; Species Specificity | 2000 |
The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake.
Topics: Animals; Conditioning, Operant; Dorsomedial Hypothalamic Nucleus; Drinking; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Hypothalamus; Male; Neuropeptide Y; Neurotransmitter Agents; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Taste | 2000 |
Glucagon-like peptide-1 improves insulin and proinsulin binding on RINm5F cells and human monocytes.
Topics: Adult; Animals; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulin; Insulinoma; Male; Monocytes; Pancreatic Neoplasms; Peptide Fragments; Peptides; Proinsulin; Protein Precursors; Rats; Receptors, Glucagon; Tumor Cells, Cultured; Venoms | 2000 |
Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.
Topics: Animals; Diabetes Mellitus; Exenatide; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Peptide Fragments; Peptides; Promoter Regions, Genetic; Protein Precursors; Trans-Activators; Venoms | 2000 |
Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element.
Topics: Animals; Base Sequence; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulinoma; Luciferases; Pancreatic Neoplasms; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Recombinant Fusion Proteins; Second Messenger Systems; Sequence Deletion; Transcription, Genetic; Tumor Cells, Cultured; Venoms | 2000 |
Glucagon-like peptide 1 increases glucose-dependent activity of the homeoprotein IDX-1 transactivating domain in pancreatic beta-cells.
Topics: Animals; Cell Line; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeodomain Proteins; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Trans-Activators; Transcriptional Activation; Transfection | 2000 |
Prolongation of the insulinotropic action of glucagon-like peptide 1 by the dimethyl ester of succinic acid in an animal model of type-2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Insulin; Male; Pancreas; Peptide Fragments; Protein Precursors; Rats; Succinates | 2000 |
PACAP contributes to insulin secretion after gastric glucose gavage in mice.
Topics: Animals; Blood Glucose; Drug Combinations; Glucagon; Glucagon-Like Peptide 1; Glucose; Injections, Intravenous; Insulin; Insulin Secretion; Intubation, Gastrointestinal; Mice; Mice, Inbred Strains; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Sodium Chloride; Stomach | 2000 |
Colocalization of numerous immunoreactivities in endocrine cells of the chicken proventriculus at hatching.
Topics: Animals; Bombesin; Chickens; Glucagon; Glucagon-Like Peptide 1; Mixed Function Oxygenases; Multienzyme Complexes; Pancreatic Polypeptide; Peptide Fragments; Peptide PHI; Protein Precursors; Proventriculus; Serotonin; Thiolester Hydrolases; Ubiquitin Thiolesterase | 2000 |
Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon.
Topics: Adaptation, Physiological; Adult; Aged; Area Under Curve; Case-Control Studies; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Ileum; Male; Middle Aged; Peptide Fragments; Peptides; Postprandial Period; Protein Precursors; Radioimmunoassay; Short Bowel Syndrome | 2000 |
Characterisation of beta-cell dysfunction of impaired glucose tolerance: evidence for impairment of incretin-induced insulin secretion.
Topics: Adult; Arginine; Blood Glucose; C-Peptide; Fasting; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Glucose Intolerance; Glycated Hemoglobin; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Reference Values | 2000 |
D-tagatose, a stereoisomer of D-fructose, increases blood uric acid concentration.
Topics: Administration, Oral; Adult; Appetite; Blood Glucose; Calorimetry, Indirect; Cholecystokinin; Cross-Over Studies; Double-Blind Method; Energy Metabolism; Epinephrine; Food-Drug Interactions; Fructose; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Hexoses; Humans; Male; Norepinephrine; Peptide Fragments; Protein Precursors; Stereoisomerism; Sweetening Agents; Uric Acid | 2000 |
cAMP-independent decrease of ATP-sensitive K+ channel activity by GLP-1 in rat pancreatic beta-cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cyclic AMP; Electric Conductivity; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Male; Membrane Potentials; Peptide Fragments; Potassium Channels; Protein Precursors; Rats; Rats, Wistar | 2000 |
Effects of centrally or systemically injected glucagon-like peptide-1 (7-36) amide on release of neurohypophysial hormones and blood pressure in the rat.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypertension; Injections, Intravenous; Male; Neurotransmitter Agents; Oxytocin; Peptide Fragments; Radioimmunoassay; Rats; Rats, Wistar; Sex Factors; Time Factors; Vasopressins | 2000 |
Elimination of glucagon-like peptide 1R signaling does not modify weight gain and islet adaptation in mice with combined disruption of leptin and GLP-1 action.
Topics: Animals; Cell Division; Crosses, Genetic; Feeding Behavior; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Heterozygote; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Male; Mice; Mice, Knockout; Mice, Obese; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Receptors, Leptin; Sex Characteristics; Signal Transduction; Weight Gain | 2000 |
Improved glucose tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice.
Topics: Animals; Blood Glucose; Body Weight; Dipeptidyl Peptidase 4; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Insulin; Insulin Secretion; Mice; Mice, Inbred C57BL; Peptide Fragments; Protease Inhibitors; Protein Precursors | 2000 |
Potentiation of the insulinotropic action of GLP-1 by succinic acid dimethyl ester in fed anaesthetized rats.
Topics: Animals; Drug Synergism; Food; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Succinates | 2000 |
Endogenous GLP-1 is involved in beta-amyloid protein-induced memory impairment and hippocampal neuronal death in rats.
Topics: Amyloid beta-Peptides; Animals; Cell Death; DNA Fragmentation; Drug Combinations; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hippocampus; Male; Memory; Memory Disorders; Neurons; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon | 2000 |
Glucagon-like peptide-1, satiety and appetite control.
Topics: Appetite Regulation; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Postprandial Period; Protein Precursors; Satiation | 1999 |
Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms.
Topics: Animals; Atropine Derivatives; Blood Glucose; Chlorisondamine; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intravenous; Insulin; Insulin Secretion; Jugular Veins; Kinetics; Male; Parasympatholytics; Peptide Fragments; Portal Vein; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice.
Topics: Animals; Blood Glucose; Fasting; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Mice; Mice, Inbred Strains; Peptide Fragments; Protein Precursors | 2000 |
Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding Sites; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Diabetes Mellitus; DNA; DNA-Binding Proteins; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Insulin; Islets of Langerhans; Male; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
A novel silencer element repressing expression of the GLP-1 receptor gene in fibroblasts and pancreatic A-cells, but not in pancreatic B- and D-cells.
Topics: Animals; Base Sequence; Cell Line; Cell Nucleus; Cloning, Molecular; Cricetinae; Cross-Linking Reagents; Deoxyribonuclease I; Enhancer Elements, Genetic; Fibroblasts; Gene Deletion; Gene Silencing; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Luciferases; Molecular Sequence Data; Pancreas; Peptide Fragments; Plasmids; Promoter Regions, Genetic; Protein Precursors; Rats; Receptors, Glucagon; Sp1 Transcription Factor; Tissue Distribution; Transcription, Genetic; Transfection; Ultraviolet Rays | 2000 |
Ca2+ and electrolyte mobilization following agonist application to the pancreatic beta cell line HIT.
Topics: Animals; Calcium; Cytoplasm; Cytoplasmic Granules; Electrolytes; Electron Probe Microanalysis; Extracellular Space; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Islets of Langerhans; Microscopy, Confocal; Microscopy, Electron; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Tumor Cells, Cultured | 2000 |
Reduced GLP-1 and insulin responses and glucose intolerance after gastric glucose in GRP receptor-deleted mice.
Topics: Animals; Blood Glucose; Enzyme-Linked Immunosorbent Assay; Female; Gastric Lavage; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Protein Precursors; Receptors, Bombesin | 2000 |
Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Division; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Enzyme Activation; Glucagon; Glucagon-Like Peptide 1; Glucose; Guanine Nucleotide Exchange Factors; Humans; Insulin; Islets of Langerhans; MAP Kinase Signaling System; Models, Biological; Peptide Fragments; Polymerase Chain Reaction; Protein Binding; Protein Precursors; rap1 GTP-Binding Proteins; ras Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription, Genetic | 2000 |
Effects of glucagon-like peptide-1 (GLP-1) on glucose homeostasis and food intake.
Topics: Animals; Dipeptidyl Peptidase 4; Eating; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Homeostasis; Insulin; Intestinal Mucosa; Neurotransmitter Agents; Nitriles; Peptide Fragments; Protease Inhibitors; Pyrrolidines; Rats | 2000 |
Oral delivery of glucagon-like peptide-1 in a modified polymer preparation normalizes basal glycaemia in diabetic db/db mice.
Topics: 3-O-Methylglucose; Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Drug Carriers; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Kinetics; Mice; Microspheres; Olive Oil; Peptide Fragments; Plant Oils; Polymers; Protein Precursors | 2000 |
Adaptive changes in insulin secretion by islets from neonatal rats raised on a high-carbohydrate formula.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Animals, Newborn; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP-Dependent Protein Kinases; Dietary Carbohydrates; Enzyme Inhibitors; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Hyperinsulinism; Insulin; Insulin Secretion; Islets of Langerhans; Norepinephrine; Peptide Fragments; Pregnancy; Protein Kinase C; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; RNA, Messenger; Signal Transduction | 2000 |
Glucagon-like peptide-1 induces cell proliferation and pancreatic-duodenum homeobox-1 expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats.
Topics: Aging; Animals; Blood Glucose; Cell Division; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Homeodomain Proteins; Insulin; Islets of Langerhans; Pancreas; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Trans-Activators | 2000 |
Glucagon-like peptide (GLP)-1 and leptin concentrations in obese patients with Type 2 diabetes mellitus.
Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hyperinsulinism; Insulin; Leptin; Male; Middle Aged; Obesity; Peptide Fragments; Protein Precursors | 2000 |
Impaired neural regulation of insulin secretion related to the leptin receptor gene mutation in Wistar fatty rats.
Topics: Animals; Atropine Derivatives; Blood Glucose; Carrier Proteins; Crosses, Genetic; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Injections, Intraventricular; Insulin; Insulin Resistance; Insulin Secretion; Mutation; Obesity; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred WKY; Rats, Zucker; Receptors, Cell Surface; Receptors, Leptin; Vagotomy; Vagus Nerve | 2000 |
Degradation and glycemic effects of His(7)-glucitol glucagon-like peptide-1(7-36)amide in obese diabetic ob/ob mice.
Topics: Animals; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin; Mice; Mice, Obese; Oligopeptides; Peptide Fragments; Protease Inhibitors; Protein Precursors; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2001 |
Effects of skyrin, a receptor-selective glucagon antagonist, in rat and human hepatocytes.
Topics: Animals; Anthraquinones; Cells, Cultured; CHO Cells; Cricetinae; Cyclic AMP; Epinephrine; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycogen; Hepatocytes; Humans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Transfection | 2000 |
Lack of effect of incretin hormones on insulin release from pancreatic islets in the bile duct-ligated rats.
Topics: Animals; Bile Ducts; Bilirubin; Bucladesine; Cholestasis, Extrahepatic; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Heterotrimeric GTP-Binding Proteins; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Ligation; Male; Peptide Fragments; Rats; Rats, Wistar | 2001 |
A new hypoglycemic agent, JTT-608, evokes protein kinase A-mediated Ca(2+) signaling in rat islet beta-cells: strict regulation by glucose, link to insulin release, and cooperation with glucagon-like peptide-1(7-36)amide and pituitary adenylate cyclase-ac
Topics: Acetylcholine; Animals; Butyrates; Calcium Channel Blockers; Calcium Signaling; Cell Separation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclohexanes; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hypoglycemic Agents; Insulin; Islets of Langerhans; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar | 2001 |
Differential effects of glucagon-like peptide-1 (7-36)amide versus cholecystokinin on arginine-induced islet hormone release in vivo and in vitro.
Topics: Animals; Arginine; Cholecystokinin; Drug Combinations; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Male; Mice; Pancreas; Peptide Fragments; Perfusion; Rats; Somatostatin | 2001 |
Glucagon-like peptide-1 stimulates insulin secretion by a Ca2+-independent mechanism in Zucker diabetic fatty rat islets of Langerhans.
Topics: Animals; Calcium; Diabetes Mellitus; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Obesity; Peptide Fragments; Protein Precursors; Rats; Rats, Zucker | 2000 |
Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aspartic Acid Endopeptidases; Cell Line; Colforsin; Gene Expression Regulation; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Kinetics; Luciferases; Mice; Peptide Fragments; Proglucagon; Proprotein Convertase 1; Proprotein Convertases; Protein Precursors; Rats; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection | 2001 |
Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Line; Cells, Cultured; Cloning, Molecular; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Male; Peptide Fragments; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Precursors; Protein Subunits; Rats; Rats, Wistar; Receptors, Drug; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Deletion; Sulfonylurea Receptors; Transcription, Genetic; Transfection | 2001 |
Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT).
Topics: Calcium; Cell Line; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hydrogen-Ion Concentration; Intracellular Membranes; Islets of Langerhans; Lactones; Lipase; Lipolysis; Orlistat; Peptide Fragments; Protein Precursors; Sterol Esterase | 2001 |
Expression of glucagon-like peptide-1 (GLP-1) receptor and the effect of GLP-1-(7-36) amide on insulin release by pancreatic islets during rat ontogenic development.
Topics: Age Factors; Animals; Blotting, Southern; DNA, Complementary; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Polymerase Chain Reaction; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; RNA, Messenger; Time Factors | 2001 |
Intestinal proliferation and delayed intestinal transit in a patient with a GLP-1-, GLP-2- and PYY-producing neuroendocrine carcinoma.
Topics: Cell Division; Gastrointestinal Transit; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Intestinal Mucosa; Intestine, Small; Jejunum; Liver Neoplasms; Male; Neoplasms, Unknown Primary; Neuroendocrine Tumors; Peptide Fragments; Peptides; Peritoneal Neoplasms; Protein Precursors | 2001 |
The inhibitory mechanism of GLP-1, but not glucagon, on fasted gut motility is dependent on the L-arginine/nitric oxide pathway.
Topics: Animals; Arginine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fasting; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Male; Myoelectric Complex, Migrating; Nitric Oxide; Nitroarginine; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 2001 |
Monounsaturated fatty acid diets improve glycemic tolerance through increased secretion of glucagon-like peptide-1.
Topics: Administration, Oral; Animals; Body Weight; Cell Line; Dietary Fats; Duodenum; Eating; Fatty Acids; Fatty Acids, Monounsaturated; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Glucose Tolerance Test; Male; Oleic Acid; Palmitic Acid; Peptide Fragments; Protein Precursors; Rats; Rats, Zucker | 2001 |
Insulinotropic hormone glucagon-like peptide 1 (GLP-1) activation of insulin gene promoter inhibited by p38 mitogen-activated protein kinase.
Topics: Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Imidazoles; Insulin; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Pyridines; Rats; Response Elements; Signal Transduction; Time Factors | 2001 |
Integrative mitogenic role of protein kinase B/Akt in beta-cells.
Topics: Animals; Cell Division; Cell Line; Enzyme Activation; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin-Like Growth Factor I; Islets of Langerhans; Mitogens; Peptide Fragments; Phosphatidylinositol 3-Kinases; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction | 2000 |
Synergistic interaction between VIP-related peptides and bombesin on ion transport in guinea pig distal colonic mucosa.
Topics: Animals; Bombesin; Colon; Dose-Response Relationship, Drug; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Male; Neuropeptides; Peptide Fragments; Peptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Vasoactive Intestinal Peptide | 2000 |
Distinctive effects of glicentin, GLP-1 and GLP-2 on adaptive response to massive distal small intestine resection in rats.
Topics: Adaptation, Physiological; alpha-Glucosidases; Animals; DNA; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Growth Substances; Intestine, Small; Male; Organ Size; Peptide Fragments; Peptides; Protein Precursors; Proteins; Rats; Rats, Wistar; Sucrase; Time Factors | 2000 |
Cytosolic calcium handling in islets of normal Wistar and diabetic Goto Kakizaki rats in the presence of glucose and truncated glucagon-like peptide 1 (7-36) amide.
Topics: Animals; Calcium; Cytosol; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Rats; Rats, Wistar | 2000 |
Colocalization of GLP-1 and GIP in human and porcine intestine.
Topics: Animals; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Immunohistochemistry; Intestine, Small; Peptide Fragments; Peptide YY; Protein Precursors; Species Specificity; Swine; Tissue Distribution | 2000 |
Insulinotropin PACAP potentiates insulin action. Stimulation of glucose uptake in 3T3-LI adipocytes.
Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport, Active; Deoxyglucose; Diabetes Mellitus, Type 2; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Mice; Models, Biological; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; Receptors, Pituitary Hormone | 2000 |
Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly.
Topics: Aged; Aged, 80 and over; Appetite; Blood Glucose; Dietary Carbohydrates; Dietary Fats, Unsaturated; Energy Intake; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Humans; Insulin; Kinetics; Male; Olive Oil; Peptide Fragments; Plant Oils; Protein Precursors; Regression Analysis; Time Factors | 2001 |
The effect of zinc-crystallized glucagon-like peptide-1 on insulin secretion of macroencapsulated pancreatic islets.
Topics: Animals; Cell Survival; Crystallization; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreas, Artificial; Peptide Fragments; Perfusion; Polymers; Protein Precursors; Rats; Rats, Sprague-Dawley; Zinc | 2001 |
Action of glucagon and glucagon-like peptide-1-(7-36) amide on lipolysis in human subcutaneous adipose tissue and skeletal muscle in vivo.
Topics: Adipose Tissue; Adult; Blood Flow Velocity; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycerol; Humans; Isoproterenol; Lipolysis; Male; Microdialysis; Muscle, Skeletal; Peptide Fragments | 2001 |
Evidence against a rate-limiting role of proinsulin processing for maximal insulin secretion in subjects with impaired glucose tolerance and beta-cell dysfunction.
Topics: Adult; Arginine; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Intolerance; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Middle Aged; Peptide Fragments; Proinsulin; Protein Precursors | 2001 |
Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques.
Topics: Animals; Atropine; Blood Glucose; Food; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Kinetics; Macaca mulatta; Male; Muscarinic Antagonists; Nicotinic Antagonists; Pancreatic Polypeptide; Parasympathetic Nervous System; Peptide Fragments; Protein Precursors; Trimethaphan | 2001 |
Effect of glucagon-like peptide-1(7-36)-amide on initial splanchnic glucose uptake and insulin action in humans with type 1 diabetes.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Duodenum; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Human Growth Hormone; Hydrocortisone; Hypoglycemic Agents; Insulin; Intubation; Osmolar Concentration; Peptide Fragments; Viscera | 2001 |
Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients.
Topics: Aged; C-Peptide; Diabetes Mellitus, Type 2; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Middle Aged; Osmolar Concentration; Peptide Fragments; Postprandial Period; Protein Precursors; Reference Values | 2001 |
No reactive hypoglycaemia in Type 2 diabetic patients after subcutaneous administration of GLP-1 and intravenous glucose.
Topics: Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemia; Hypoglycemic Agents; Infusions, Intravenous; Injections, Subcutaneous; Insulin; Kinetics; Male; Middle Aged; Peptide Fragments; Protein Precursors; Reference Values | 2001 |
GLP-1 inhibits gastric emptying of water but does not influence plasma.
Topics: Acetylcholine; Adult; Blood Glucose; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; In Vitro Techniques; Insulin; Male; Osmolar Concentration; Peptide Fragments; Protein Precursors; Sodium; Vasopressins | 2001 |
Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Binding, Competitive; CHO Cells; Cricetinae; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Injections, Intraperitoneal; Injections, Subcutaneous; Mice; Mice, Inbred C57BL; Mice, Obese; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Radioligand Assay; Receptors, Glucagon; Sequence Deletion; Structure-Activity Relationship | 2001 |
Effects of glucose and amino acids on free ADP in betaHC9 insulin-secreting cells.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acids; Animals; Cell Line; Creatine; Creatine Kinase; Diazoxide; Drug Combinations; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Osmolar Concentration; Peptide Fragments; Phosphocreatine; Potassium Chloride; Protein Precursors; Time Factors | 2001 |
Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.
Topics: Animals; Colforsin; Diabetes Mellitus, Type 2; Diazoxide; Disease Models, Animal; Disease Susceptibility; Gerbillinae; Glucagon; Glucagon-Like Peptide 1; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Oxidation-Reduction; Peptide Fragments; Protein Kinase C; Protein Precursors; Rats; Rats, Sprague-Dawley; Reference Values; Signal Transduction; Tetradecanoylphorbol Acetate | 2001 |
Nutrient regulation of post-heparin lipoprotein lipase activity in obese subjects.
Topics: Adult; Anticoagulants; Blood Glucose; Dietary Carbohydrates; Dietary Fats; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Heparin; Humans; Insulin; Lipoprotein Lipase; Obesity; Peptide Fragments; Protein Precursors; Triglycerides | 2001 |
Glucagon-like peptide-1(7-36) amide stimulates surfactant secretion in human type II pneumocytes.
Topics: Adult; Cells, Cultured; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Lung; Male; Middle Aged; Peptide Fragments; Phosphatidylcholines; Pulmonary Surfactants; Reference Values; Sensitivity and Specificity | 2001 |
Glucagon-like peptide 1 induces differentiation of islet duodenal homeobox-1-positive pancreatic ductal cells into insulin-secreting cells.
Topics: Actins; Animals; Cell Differentiation; Cell Line; Culture Media; Flow Cytometry; Fluorescent Antibody Technique; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Humans; Immunohistochemistry; Insulin; Pancreatic Ducts; Peptide Fragments; Protein Precursors; Rats; RNA, Messenger; Trans-Activators | 2001 |
Effect of GLP-1 on lipid metabolism in human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Cyclic AMP; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Lipid Metabolism; Lipids; Lipolysis; Male; Middle Aged; Peptide Fragments; Protein Precursors | 2001 |
Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Appetite; Blood Glucose; Eating; Electromyography; Energy Intake; Enteral Nutrition; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Intestine, Small; Male; Myoelectric Complex, Migrating; Peptide Fragments; Protein Precursors | 2001 |
Glucagon-like peptide-1 causes pancreatic duodenal homeobox-1 protein translocation from the cytoplasm to the nucleus of pancreatic beta-cells by a cyclic adenosine monophosphate/protein kinase A-dependent mechanism.
Topics: Animals; Biological Transport; Cell Nucleus; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Cytoplasm; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeodomain Proteins; Insulin; Insulin Secretion; Isoquinolines; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; RNA, Messenger; Sulfonamides; Trans-Activators; Tumor Cells, Cultured | 2001 |
Insulinotropic actions of exendin-4 and glucagon-like peptide-1 in vivo and in vitro.
Topics: Animals; Blood Glucose; Culture Techniques; Exenatide; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Venoms | 2001 |
The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia.
Topics: Area Under Curve; Blood Glucose; Blood Pressure; Body Mass Index; Eating; Female; Ganglionic Blockers; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Middle Aged; Peptide Fragments; Postmenopause; Postprandial Period; Protein Precursors; Reference Values; Time Factors; Trimethaphan | 2001 |
Glucagon-like peptide-1 (7-37) augments insulin release in elderly patients with diabetes.
Topics: Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Clamp Technique; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Peptide Fragments; Peptides | 2001 |
Potentiation by methyl pyruvate of GLP-1 insulinotropic action in normal rats.
Topics: Animals; B-Lymphocytes; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose; Hypoglycemia; Insulin; Male; Peptide Fragments; Protein Precursors; Pyruvates; Rats; Rats, Wistar; Time Factors | 2001 |
Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice.
Topics: Animals; Cell Count; Glucagon; Glucagon-Like Peptide 1; Image Processing, Computer-Assisted; Immunoenzyme Techniques; Insulin; Islets of Langerhans; Mice; Mice, Inbred Strains; Mice, Knockout; Peptide Fragments; Protein Precursors; Signal Transduction; Specific Pathogen-Free Organisms; Tissue Distribution | 2001 |
Attenuated processing of proglucagon and glucagon-like peptide-1 in carboxypeptidase E-deficient mice.
Topics: Animals; Carboxypeptidase H; Carboxypeptidases; Chromatography, Gel; Diabetes Mellitus, Experimental; Furin; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Mice; Mice, Mutant Strains; Obesity; Pancreas; Peptide Fragments; Proglucagon; Protein Precursors; Subtilisins; Tissue Extracts | 2001 |
Amphibian glucagon family peptides: potent metabolic regulators in fish hepatocytes.
Topics: Amino Acid Sequence; Animals; Bufo marinus; Catfishes; Cattle; Fishes; Glucagon; Glucagon-Like Peptide 1; Hepatocytes; Humans; Molecular Sequence Data; Peptide Fragments; Phosphorylases; Protein Precursors; Xenopus laevis | 2001 |
An interaction between hypothalamic glucagon-like peptide-1 and macronutrient composition determines food intake in rats.
Topics: Animals; Diet; Dietary Carbohydrates; Down-Regulation; Eating; Glucagon; Glucagon-Like Peptide 1; Hypothalamus; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Time Factors | 2001 |
Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats.
Topics: Animals; Blood Glucose; Dipeptidyl Peptidase 4; Duodenum; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Insulin; Insulin Secretion; Intubation, Gastrointestinal; Male; Peptide Fragments; Protein Precursors; Pyrroles; Rats; Rats, Inbred F344; Rats, Mutant Strains; Species Specificity; Valine | 2001 |
Neuropeptide regulation of feeding in catfish, Ictalurus punctatus: a role for glucagon-like peptide-1 (GLP-1)?
Topics: Animals; Eating; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Ictaluridae; Immune Sera; Neuropeptides; Peptide Fragments; Protein Precursors | 2001 |
Exendin-4 reduces fasting and postprandial glucose and decreases energy intake in healthy volunteers.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Animals; Area Under Curve; Blood Glucose; Depression, Chemical; Energy Intake; Energy Metabolism; Exenatide; Fasting; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Hormones; Humans; Infusions, Intravenous; Insulin; Lizards; Male; Nausea; Peptide Fragments; Peptides; Postprandial Period; Protein Precursors; Satiety Response; Venoms | 2001 |
Proglucagon-derived peptides in intestinal epithelial proliferation: glucagon-like peptide-2 is a major mediator of intestinal epithelial proliferation in rats.
Topics: Animals; Cell Division; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Intestinal Mucosa; Male; Peptides; Proglucagon; Protein Precursors; Rats; Rats, Wistar | 2001 |
Effects of abomasal infusion of long-chain fatty acids on splanchnic metabolism of pancreatic and gut hormones in lactating dairy cows.
Topics: Abomasum; Animals; Cattle; Cholecystokinin; Digestion; Fatty Acids; Fatty Acids, Monounsaturated; Female; Glucagon; Glucagon-Like Peptide 1; Insulin; Kinetics; Lactation; Milk; Pancreas; Pancreatic Hormones; Peptide Fragments; Plant Oils; Protein Precursors; Rapeseed Oil; Spleen; Sunflower Oil | 2001 |
Glucagon-like peptide-1 and exendin-4 stimulate beta-cell neogenesis in streptozotocin-treated newborn rats resulting in persistently improved glucose homeostasis at adult age.
Topics: Animals; Animals, Newborn; Apoptosis; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Immunohistochemistry; Insulin; Islets of Langerhans; Organ Size; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Venoms | 2001 |
Involvement of calmodulin in glucagon-like peptide 1(7-36) amide-induced inhibition of the ATP-sensitive K+ channel in mouse pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calmodulin; Electrophysiology; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypoglycemic Agents; Imidazoles; Islets of Langerhans; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Peptide Fragments; Potassium Channels; Sulfonamides; Tolbutamide | 2001 |
Insulin resistance and type 2 diabetes: time for a new hypothesis.
Topics: Amyloid; Animals; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Islet Amyloid Polypeptide; Leptin; Mice; Peptide Fragments; Protein Precursors; Tumor Necrosis Factor-alpha | 2001 |
Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor.
Topics: Animals; Blood Glucose; Catheters, Indwelling; Enzyme-Linked Immunosorbent Assay; Fasting; Femoral Vein; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hepatic Veins; Homeostasis; Infusions, Intravenous; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Peptide Fragments; Portal System; Portal Vein; Protein Precursors; Tritium; Venoms | 2001 |
Gastric myoelectrical activity and gut hormone secretion in myotonic dystrophy.
Topics: Adult; Electrophysiology; Female; Gastric Emptying; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Motilin; Myoelectric Complex, Migrating; Myotonic Dystrophy; Peptide Fragments; Postprandial Period; Protein Precursors | 2001 |
The role of postprandial releases of insulin and incretin hormones in meal-induced satiety--effect of obesity and weight reduction.
Topics: Absorptiometry, Photon; Adult; Appetite; Area Under Curve; Energy Intake; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Resistance; Insulin Secretion; Male; Middle Aged; Obesity; Peptide Fragments; Postprandial Period; Satiation; Weight Loss | 2001 |
Determinants of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients.
Topics: Analysis of Variance; Autoantibodies; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Fasting; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Glutamate Decarboxylase; Glycated Hemoglobin; Humans; Insulin; Male; Middle Aged; Pancreatic Polypeptide; Peptide Fragments; Peptides; Protein Precursors; Reference Values | 2001 |
Determinants of the effectiveness of glucagon-like peptide-1 in type 2 diabetes.
Topics: Area Under Curve; Autoantibodies; Blood Glucose; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dipeptidyl Peptidase 4; Fasting; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Glutamate Decarboxylase; Glycated Hemoglobin; Humans; Infusions, Intravenous; Insulin; Islets of Langerhans; Isoenzymes; Male; Middle Aged; Peptide Fragments; Protein Precursors; Regression Analysis | 2001 |
Reduction of incretin-like salivatin in saliva from patients with type 2 diabetes and in parotid glands of streptozotocin-diabetic BALB/c mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Eating; Enzyme-Linked Immunosorbent Assay; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Male; Mice; Mice, Inbred BALB C; Microscopy, Immunoelectron; Parotid Gland; Peptide Fragments; Peptides; Postprandial Period; Proline-Rich Protein Domains; Saliva; Salivary Proline-Rich Proteins | 2001 |
Effect of aging and diabetes on the enteroinsular axis.
Topics: Adult; Aged; Aged, 80 and over; Aging; Diabetes Mellitus; Dipeptidyl Peptidase 4; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Intestines; Islets of Langerhans; Male; Peptide Fragments; Protease Inhibitors; Protein Precursors | 2001 |
When is cAMP not cAMP? Effects of compartmentalization.
Topics: Animals; Calcium; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Heart; Isoproterenol; Myocardial Contraction; Myocardium; Peptide Fragments; Protein Precursors; Rats; Time Factors | 2001 |
Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes.
Topics: Animals; Calcium; Cardiotonic Agents; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Electric Stimulation; Glucagon; Glucagon-Like Peptide 1; Heart; Hydrogen-Ion Concentration; Isoproterenol; Male; Myocardial Contraction; Myocardium; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Thionucleotides; Time Factors | 2001 |
Contribution to glucose tolerance of insulin-independent vs. insulin-dependent mechanisms in mice.
Topics: Animals; Area Under Curve; Blood Glucose; Diazoxide; Dietary Fats; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Injections, Intravenous; Insulin; Insulin Secretion; Kinetics; Mice; Mice, Inbred Strains; Models, Biological; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Regression Analysis | 2001 |
Plasma hormone levels and central c-Fos expression in ferrets after systemic administration of cholecystokinin.
Topics: Animals; Arginine Vasopressin; Behavior, Animal; Brain Stem; Cell Count; Cholecystokinin; Dose-Response Relationship, Drug; Ferrets; Glucagon; Glucagon-Like Peptide 1; Infusions, Intravenous; Injections, Intraperitoneal; Lithium Chloride; Male; Neurons; Organ Specificity; Oxytocin; Peptide Fragments; Pituitary Hormones, Posterior; Prosencephalon; Protein Precursors; Proto-Oncogene Proteins c-fos; Vomiting | 2001 |
Urinary excretion of glucagon-like peptide 1 (GLP-1) 7-36 amide in human type 2 (non-insulin-dependent) diabetes mellitus.
Topics: Aged; Albuminuria; Body Mass Index; C-Peptide; Creatinine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycated Hemoglobin; Humans; Male; Metabolic Clearance Rate; Middle Aged; Peptide Fragments | 2001 |
Insertion of an N-terminal 6-aminohexanoic acid after the 7 amino acid position of glucagon-like peptide-1 produces a long-acting hypoglycemic agent.
Topics: Amino Acid Sequence; Aminocaproic Acid; Animals; Cell Line; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Molecular Sequence Data; Mutagenesis, Insertional; Peptide Fragments; Protein Precursors; Rats; Structure-Activity Relationship | 2001 |
A human cellular model for studying the regulation of glucagon-like peptide-1 secretion.
Topics: Animals; Cell Line; Diet; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Humans; Intestines; Oleic Acid; Palmitic Acid; Peptide Fragments; Protein Hydrolysates; Protein Precursors | 2001 |
Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cell Nucleus; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Mitogen-Activated Protein Kinases; Mutation; p38 Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphatidylinositol 3-Kinases; Protein Kinase C; Protein Precursors; Rats; Rats, Wistar; Signal Transduction | 2001 |
Postprandial GLP-1, norepinephrine, and reactive hypoglycemia in dumping syndrome.
Topics: Chromatography, Gel; Dumping Syndrome; Glucagon; Glucagon-Like Peptide 1; Hematocrit; Humans; Hypoglycemia; Middle Aged; Norepinephrine; Peptide Fragments; Postprandial Period; Protein Precursors | 2001 |
Effect of glucagon, glicentin, glucagon-like peptide-1 and -2 on interdigestive gastroduodenal motility in dogs with a vagally denervated gastric pouch.
Topics: Animals; Dogs; Female; Gastrointestinal Motility; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Male; Peptide Fragments; Peptides; Protein Precursors; Stomach; Vagotomy | 2001 |
Intracerebroventricular injection of exendin (5-39) increases food intake of layer-type chicks but not broiler chicks.
Topics: Animals; Animals, Newborn; Chickens; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Injections, Intraventricular; Peptide Fragments; Protein Precursors | 2001 |
Critical role of cAMP-GEFII--Rim2 complex in incretin-potentiated insulin secretion.
Topics: Animals; Base Sequence; Carrier Proteins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Primers; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; GTP-Binding Proteins; Guanine Nucleotide Exchange Factors; Imines; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Nerve Tissue Proteins; Nuclear Proteins; Peptide Fragments; Protein Precursors | 2001 |
Potentiation by glutamic acid dimethyl ester of GLP-1 insulinotropic action in fed anaesthetized rats.
Topics: Anesthesia; Animals; Blood Glucose; Diet; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Glutamates; Insulin; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Time Factors | 2001 |
Systemic administration of the long-acting GLP-1 derivative NN2211 induces lasting and reversible weight loss in both normal and obese rats.
Topics: Animals; Blood Glucose; Body Weight; Defecation; Diuresis; Dose-Response Relationship, Drug; Drinking; Drug Administration Schedule; Eating; Energy Metabolism; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Lipids; Liraglutide; Male; Obesity; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Reference Values; Time Factors | 2001 |
Exendin-4 and glucagon-like-peptide-1: NMR structural comparisons in the solution and micelle-associated states.
Topics: Amino Acid Sequence; Binding Sites; Circular Dichroism; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glycine; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutation; Peptide Fragments; Peptides; Phosphatidylcholines; Protein Precursors; Protein Structure, Secondary; Sequence Homology, Amino Acid; Stereoisomerism; Trifluoroethanol; Tryptophan; Venoms | 2001 |
IMPAN cells: a pancreatic model for differentiation into endocrine cells.
Topics: Activins; Animals; Basic Helix-Loop-Helix Transcription Factors; Cattle; Cell Differentiation; Cell Line; Collagen; Collagen Type I; Endocrine Glands; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Inhibin-beta Subunits; Insulin; Liraglutide; Mice; Mice, Transgenic; Nerve Tissue Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stem Cells; Temperature; Trans-Activators | 2001 |
Interaction of corticotropin-releasing factor and glucagon-like peptide-1 on behaviors in chicks.
Topics: Animals; Animals, Newborn; Brain Chemistry; Chickens; Corticotropin-Releasing Hormone; Drug Interactions; Eating; Glucagon; Glucagon-Like Peptide 1; Injections, Intraventricular; Locomotion; Male; Peptide Fragments; Protein Precursors; Vocalization, Animal | 2001 |
Identification of a proglucagon cDNA from Rana tigrina rugulosa that encodes two GLP-1s and that is alternatively spliced in a tissue-specific manner.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; DNA, Complementary; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Molecular Sequence Data; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Random Amplified Polymorphic DNA Technique; Ranidae; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2001 |
The Caenorhabditis elegans polarity gene ooc-5 encodes a Torsin-related protein of the AAA ATPase superfamily.
Topics: Adenosine Triphosphatases; Animals; Blastomeres; Body Patterning; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Lineage; Cell Polarity; Cloning, Molecular; Endopeptidase Clp; Endoplasmic Reticulum; Germ Cells; Glucagon; Glucagon-Like Peptide 1; Heat-Shock Proteins; Intestines; Membrane Proteins; Molecular Chaperones; Molecular Sequence Data; Multigene Family; Peptide Fragments; Protein Precursors; Protozoan Proteins; Serine Endopeptidases | 2001 |
Effect of GLP-1 treatment on GLUT2 and GLUT4 expression in type 1 and type 2 rat diabetic models.
Topics: Adipose Tissue; Animals; Blotting, Northern; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 2; Glucose Transporter Type 4; Liver; Male; Monosaccharide Transport Proteins; Muscle Proteins; Muscle, Skeletal; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger | 2001 |
Vasorelaxant effect of glucagon-like peptide-(7-36)amide and amylin on the pulmonary circulation of the rat.
Topics: Acetylcholine; Amyloid; Animals; Anti-Ulcer Agents; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Islet Amyloid Polypeptide; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Norepinephrine; Peptide Fragments; Perfusion; Pulmonary Artery; Pulmonary Circulation; Pulmonary Ventilation; Rats; Rats, Sprague-Dawley; Trachea; Vasoactive Intestinal Peptide; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2001 |
Medium-dependence of the secondary structure of exendin-4 and glucagon-like-peptide-1.
Topics: Amino Acid Sequence; Circular Dichroism; Exenatide; Glucagon; Glucagon-Like Peptide 1; Humans; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Protein Structure, Secondary; Sequence Homology, Amino Acid; Venoms | 2002 |
Human glucagon gene promoter sequences regulating tissue-specific versus nutrient-regulated gene expression.
Topics: Animal Nutritional Physiological Phenomena; Animals; Diet; Dietary Fiber; DNA Primers; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Human Growth Hormone; Humans; Insulin; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Organ Size; Peptide Fragments; Peptides; Promoter Regions, Genetic; Protein Precursors; RNA, Messenger | 2002 |
Suppression by exendin(9-39)amide of glucagon-like peptide-1 insulinotropic action in rats infused with dimethyl ester of succinic acid.
Topics: Animals; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Insulin; Lizards; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Venoms | 2001 |
Renal effects of glucagon-like peptide in rats.
Topics: Animals; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Kidney; Male; Neurotransmitter Agents; Peptide Fragments; Rats; Rats, Sprague-Dawley | 2002 |
tGLP-1 and release of vasopressin and oxytocin from the isolated rat hypothalamo-neurohypophysial system: effects of a tGLP-1 receptor agonist and antagonist.
Topics: Animals; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamo-Hypophyseal System; Hypothalamus, Middle; In Vitro Techniques; Male; Oxytocin; Peptide Fragments; Peptides; Rats; Rats, Wistar; Vasopressins | 2001 |
GLP-1 effect upon the GPI/IPG system in adipocytes and hepatocytes from diabetic rats.
Topics: Adipocytes; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glycosylphosphatidylinositols; Hepatocytes; Hypoglycemic Agents; Inositol Phosphates; Insulin; Liver; Male; Oligosaccharides; Pancreas; Peptide Fragments; Polysaccharides; Protein Precursors; Rats; Rats, Wistar | 2001 |
Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Colforsin; Cyclic AMP; Diazoxide; Glucagon; Glucagon-Like Peptide 1; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Phosphodiesterase Inhibitors; Potassium Channels; Protein Precursors; Rats; Rats, Wistar; Signal Transduction; Sodium Azide; Vasodilator Agents | 2002 |
Bioactive polymers for biohybrid artificial pancreas.
Topics: Animals; Bioartificial Organs; Cell Culture Techniques; Crystallization; Extracellular Matrix; Glucagon; Glucagon-Like Peptide 1; Hemoglobins; Insulin; Insulin Secretion; Islets of Langerhans; Oxygen; Pancreas; Peptide Fragments; Polyethylene Glycols; Polymers; Protein Precursors; Rats; Tissue Engineering | 2001 |
Effects of glucagon-like peptide-1(7-36) amide on neurohypophysial and cardiovascular functions under hypo- or normotensive hypovolaemia in the rat.
Topics: Analysis of Variance; Animals; Arginine Vasopressin; Blood Pressure; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypovolemia; Male; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Rats; Rats, Wistar | 2002 |
Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs.
Topics: Animals; Area Under Curve; Blood Glucose; Dipeptidyl Peptidase 4; Dogs; Eating; Enzyme Inhibitors; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Nitriles; Peptide Fragments; Protein Precursors; Pyrrolidines | 2002 |
Glucagon-like peptide containing pathways in the regulation of feeding behaviour.
Topics: Angiotensin II; Animals; Behavior, Animal; Drinking; Eating; Fasting; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Male; Neuropeptide Y; Peptide Fragments; Protein Precursors; Rats | 2001 |
Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic beta-cell lines for use in transplantation.
Topics: Animals; Autocrine Communication; Cell Line; Diabetes Mellitus; Enzyme Inhibitors; Exenatide; Gene Expression Regulation; Genetic Engineering; Glucagon; Glucagon-Like Peptide 1; Indoles; Insulin; Insulinoma; Islets of Langerhans; Islets of Langerhans Transplantation; Peptide Fragments; Peptides; Promoter Regions, Genetic; Protein Kinase C; Protein Precursors; Rats; Receptors, Peptide; Recombinant Proteins; Research Design; Second Messenger Systems; Tumor Cells, Cultured; Venoms | 2002 |
Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus.
Topics: Animals; Down-Regulation; Exenatide; Glucagon; Glucagon-Like Peptide 1; Hypothalamus; Injections, Intraventricular; Male; Neurons; Neurotransmitter Agents; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Serotonin; Venoms | 2002 |
Anxiogenic-like action of centrally administered glucagon-like peptide-1 in a punished drinking test.
Topics: Amygdala; Animals; Anxiety; Cerebral Ventricles; Conflict, Psychological; Drinking Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Infusions, Parenteral; Male; Maze Learning; Motor Activity; Peptide Fragments; Protein Precursors; Punishment; Rats; Rats, Sprague-Dawley | 2002 |
Evaluation of glycated glucagon-like peptide-1(7-36)amide in intestinal tissue of normal and diabetic animal models.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycosylation; Hydrocortisone; Intestine, Small; Mice; Mice, Obese; Organ Size; Peptide Fragments; Rats | 2002 |
Expression of a novel zinc-finger cDNA, IA-1, is associated with rat AR42J cells differentiation into insulin-positive cells.
Topics: Adult; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Culture Media, Conditioned; DNA-Binding Proteins; DNA, Complementary; Fetus; Gene Expression Regulation, Developmental; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Humans; Insulin; Insulinoma; Islets of Langerhans; Mice; Peptide Fragments; Protein Precursors; Rats; Repressor Proteins; RNA, Messenger; Trans-Activators; Tumor Cells, Cultured; Zinc Fingers | 2002 |
A novel neurotrophic property of glucagon-like peptide 1: a promoter of nerve growth factor-mediated differentiation in PC12 cells.
Topics: Amino Acid Sequence; Animals; Antimetabolites; Apoptosis; Blotting, Western; Bromodeoxyuridine; Cell Differentiation; Cyclic AMP; DNA Replication; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Immunohistochemistry; L-Lactate Dehydrogenase; Molecular Sequence Data; Nerve Growth Factor; Neurodegenerative Diseases; PC12 Cells; Peptide Fragments; Peptides; Protein Precursors; Rats; Receptors, Glucagon; Stimulation, Chemical; Tetrazolium Salts; Thiazoles; Venoms | 2002 |
Assessment of the role of interstitial glucagon in the acute glucose secretory responsiveness of in situ pancreatic beta-cells.
Topics: Animals; Cells, Cultured; Cricetinae; Drug Synergism; Extracellular Space; Fibroblasts; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Liver; Lung; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Signal Transduction | 2002 |
NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Islets of Langerhans; Isoquinolines; NFATC Transcription Factors; Nuclear Proteins; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Sulfonamides; Tacrolimus; Transcription Factors; Transcription, Genetic | 2002 |
GLP-1-(9-36) amide reduces blood glucose in anesthetized pigs by a mechanism that does not involve insulin secretion.
Topics: Anesthesia; Animals; Blood Glucose; Chloralose; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Infusions, Intravenous; Insulin; Insulin Secretion; Kinetics; Metabolic Clearance Rate; Peptide Fragments; Peptides; Protease Inhibitors; Protein Precursors; Pyrroles; Swine; Valine | 2002 |
Correlation between GABA release from rat islet beta-cells and their metabolic state.
Topics: 1-Methyl-3-isobutylxanthine; 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Calcium; Culture Media, Conditioned; Cycloheximide; Diazoxide; gamma-Aminobutyric Acid; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamate Decarboxylase; Glyburide; Islets of Langerhans; Male; Mannoheptulose; Oxidation-Reduction; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Verapamil | 2002 |
Metformin effects on dipeptidylpeptidase IV degradation of glucagon-like peptide-1.
Topics: Animals; Dipeptides; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Hydrolysis; Hypoglycemic Agents; Kinetics; Metformin; Peptide Fragments; Protein Precursors; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity; Swine | 2002 |
Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Glutamates; Injections, Intravenous; Insulin; Peptide Fragments; Protein Precursors; Pyruvates; Rats; Time Factors | 2001 |
Abnormal release of incretins and cortisol after oral glucose in subjects with insulin-resistant myotonic dystrophy.
Topics: Adult; Body Composition; DNA; Dose-Response Relationship, Drug; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Hydrocortisone; Insulin Resistance; Male; Middle Aged; Myotonic Dystrophy; Peptide Fragments; Regression Analysis; Repetitive Sequences, Nucleic Acid | 2002 |
Glucagon-like peptide-1 response to acarbose in elderly type 2 diabetic subjects.
Topics: Acarbose; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Eating; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Peptide Fragments; Postprandial Period; Protein Precursors; Triglycerides | 2002 |
Exendin-4 increases insulin sensitivity via a PI-3-kinase-dependent mechanism: contrasting effects of GLP-1.
Topics: Animals; Drug Interactions; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin Resistance; Muscle, Skeletal; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Protein Precursors; Rats; Tumor Cells, Cultured; Venoms | 2002 |
NMR studies of the aggregation of glucagon-like peptide-1: formation of a symmetric helical dimer.
Topics: Amino Acid Sequence; Diffusion; Dimerization; Glucagon; Glucagon-Like Peptide 1; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Conformation; Protein Precursors; Protein Structure, Secondary; Trifluoroethanol; Water | 2002 |
GLP-1 as a satiety factor in children with eating disorders.
Topics: Adolescent; Anorexia Nervosa; Blood Glucose; Fasting; Feeding and Eating Disorders; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Obesity; Peptide Fragments; Protein Precursors; Satiation | 2002 |
Evidence for early impairment of glucagon-like peptide 1-induced insulin secretion in human type 2 (non insulin-dependent) diabetes.
Topics: Aged; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Disease Progression; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Middle Aged; Peptide Fragments; Protein Precursors | 2002 |
Use of the incretin hormone glucagon-like peptide-1 (GLP-1) for the detection of insulinomas: initial experimental results.
Topics: Animals; Chromatography, High Pressure Liquid; Feasibility Studies; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Iodine Radioisotopes; Neoplasm Transplantation; Pancreatic Neoplasms; Peptide Fragments; Peptides; Protein Precursors; Radionuclide Imaging; Rats; Reproducibility of Results; Sensitivity and Specificity; Tissue Distribution; Tumor Cells, Cultured | 2002 |
Persistent improvement of type 2 diabetes in the Goto-Kakizaki rat model by expansion of the beta-cell mass during the prediabetic period with glucagon-like peptide-1 or exendin-4.
Topics: Age Factors; Animals; Animals, Newborn; Blood Glucose; Body Weight; Cell Division; Diabetes Mellitus, Type 2; Disease Models, Animal; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Longitudinal Studies; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Mutant Strains; Rats, Wistar; Venoms | 2002 |
Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Drinking; Eating; Fatty Acids, Nonesterified; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Insulin; Male; Nitriles; Obesity; Pancreas; Peptide Fragments; Protease Inhibitors; Protein Precursors; Pyrrolidines; Rats; Rats, Zucker; Receptors, Glucagon; Triglycerides; Weight Gain | 2002 |
Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice.
Topics: Animals; Blood Glucose; Body Weight; Dietary Fats; Dipeptidyl Peptidase 4; Drinking; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Insulin; Insulin Resistance; Intubation, Gastrointestinal; Islets of Langerhans; Mice; Mice, Inbred C57BL; Nitriles; Organ Size; Peptide Fragments; Protease Inhibitors; Protein Precursors; Pyrrolidines; Time Factors | 2002 |
Intracerebroventricular injection of glucagon-like peptide-1 decreases monoamine concentrations in the hypothalamus of chicks.
Topics: Animals; Chickens; Dopamine; Epinephrine; Glucagon; Glucagon-Like Peptide 1; Hypothalamus; Injections, Intraventricular; Male; Norepinephrine; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Protein Precursors; Serotonin | 2002 |
Hypocretin is an early member of the incretin gene family.
Topics: Animals; Anura; Carrier Proteins; Evolution, Molecular; Exons; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypothalamus; Intracellular Signaling Peptides and Proteins; Neuropeptides; Orexins; Peptide Fragments; Phylogeny; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Sleep; Tetraodontiformes; Urochordata | 2002 |
Endoproteolysis by isolated membrane peptidases reveal metabolic stability of glucagon-like peptide-1 analogs, exendins-3 and -4.
Topics: Animals; Chromatography, High Pressure Liquid; Exenatide; Glucagon; Glucagon-Like Peptide 1; Kidney Cortex; Kinetics; Microvilli; Peptide Fragments; Peptides; Protein Precursors; Rats; Swine; Venoms | 2002 |
Muscarinic receptors control postprandial release of glucagon-like peptide-1: in vivo and in vitro studies in rats.
Topics: Anesthesia; Animals; Cell Line; Cells, Cultured; Fluorescent Antibody Technique, Indirect; Glucagon; Glucagon-Like Peptide 1; Ileum; Immunohistochemistry; Male; Nerve Fibers; Peptide Fragments; Postprandial Period; Protein Precursors; Rats; Rats, Wistar; Receptors, Muscarinic | 2002 |
A stereologic evaluation of glucagon-like peptide-1 (GLP-1) mucosal cells in the small intestine of the developing pig.
Topics: Animals; Animals, Newborn; Cell Size; Embryonic and Fetal Development; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; Intestinal Mucosa; Peptide Fragments; Protein Precursors; Swine | 2002 |
In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor.
Topics: Amino Acid Sequence; Calorimetry; Circular Dichroism; Disulfides; Escherichia coli; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Folding; Protein Precursors; Protein Structure, Tertiary; Receptors, Glucagon; Titrimetry | 2002 |
The short half-life of glucagon-like peptide-1 in plasma does not reflect its long-lasting beneficial effects.
Topics: Animals; Body Weight; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Half-Life; Insulin; Insulin Secretion; Male; Peptide Fragments; Protein Precursors; Rats; Time Factors | 2002 |
Glucagon-like peptide-1 analogue LY315902: effect on intestinal motility and release of insulin and somatostatin.
Topics: Animals; Fasting; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Male; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Somatostatin | 2002 |
Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling.
Topics: Animals; Cell Line; Circadian Rhythm; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Melatonin; Peptide Fragments; Protein Precursors; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Second Messenger Systems | 2002 |
Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes.
Topics: Analysis of Variance; Cells, Cultured; Culture Techniques; Dose-Response Relationship, Drug; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glycogen Phosphorylase; Glycogen Synthase; Humans; Isoenzymes; Muscle, Skeletal; Myocardium; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Second Messenger Systems; Venoms | 2002 |
GLP-1 receptor signaling contributes to anorexigenic effect of centrally administered oxytocin in rats.
Topics: Animals; Anorexia; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intraventricular; Male; Neurons; Neurotransmitter Agents; Oxytocin; Peptide Fragments; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Receptors, Oxytocin; Signal Transduction | 2002 |
Prolonged gastrointestinal transit in a patient with a glucagon-like peptide (GLP)-1- and -2-producing neuroendocrine tumor.
Topics: Female; Gastrointestinal Transit; Glucagon; Glucagon-Like Peptide 1; Humans; Middle Aged; Neoplasm Invasiveness; Neuroendocrine Tumors; Peptide Fragments; Peptides; Proglucagon; Protein Precursors | 2002 |
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Membrane; Cells, Cultured; Cloning, Molecular; Drosophila melanogaster; Drosophila Proteins; Endopeptidases; Enhancer Elements, Genetic; Glucagon; Glucagon-Like Peptide 1; Helminth Proteins; Homeodomain Proteins; Humans; Intracellular Membranes; Membrane Proteins; Molecular Sequence Data; Mutation; Peptide Fragments; Presenilin-1; Protein Precursors; Receptors, Notch; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Signal Transduction | 2002 |
Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat intestinal cultures.
Topics: Animals; Cells, Cultured; Fetus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Intestinal Mucosa; Intestines; Peptide Fragments; Protein Precursors; Rats; Receptors, Somatostatin; Somatostatin; Somatostatin-28 | 2002 |
Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3beta transcription factors.
Topics: Cell Differentiation; Cell Line; Cyclic AMP; DNA-Binding Proteins; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hepatocyte Nuclear Factor 3-beta; Homeodomain Proteins; Humans; Insulin; Islets of Langerhans; Mitogen-Activated Protein Kinases; Nuclear Proteins; Pancreatic Ducts; Peptide Fragments; Peptides; Promoter Regions, Genetic; Protein Precursors; Receptors, Glucagon; Trans-Activators; Transcription Factors; Transfection; Venoms | 2002 |
Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells.
Topics: Calcium; Cell Differentiation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Homeodomain Proteins; Humans; Insulin; Intermediate Filament Proteins; Islets of Langerhans; Nerve Tissue Proteins; Nestin; Peptide Fragments; Proglucagon; Protein Precursors; Receptors, Glucagon; Stem Cells; Trans-Activators; Transfection | 2002 |
Effect of stimulators such as GLP-1, PACAP, and nicotinamide on glucose-stimulated insulin secretion from porcine pancreatic endocrine cells in long-term culture.
Topics: Animals; Cell Adhesion; Cell Separation; Cells, Cultured; Culture Media; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Neuropeptides; Neurotransmitter Agents; Niacinamide; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Swine | 2002 |
Glucose dependence of insulinotropic actions of pituitary adenylate cyclase-activating polypeptide in insulin-secreting INS-1 cells.
Topics: Action Potentials; Animals; Calcium; Calcium Channels; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Neuropeptides; Neurotransmitter Agents; Pancreatic Neoplasms; Patch-Clamp Techniques; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Rats; Tumor Cells, Cultured | 2002 |
GLP-1 and GLP-2 act in concert to inhibit fasted, but not fed, small bowel motility in the rat.
Topics: Animals; Blood Glucose; Drug Interactions; Eating; Electromyography; Fasting; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Injections, Intravenous; Insulin; Intestine, Small; Male; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley | 2002 |
On combination therapy of diabetes with metformin and dipeptidyl peptidase IV inhibitors.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Metformin; Peptide Fragments; Protein Precursors | 2002 |
Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects.
Topics: Adrenocorticotropic Hormone; Animals; Aspartic Acid Endopeptidases; Corticosterone; Dwarfism; Gene Expression; Gene Targeting; Glucagon; Glucagon-Like Peptide 1; Growth Hormone; Growth Hormone-Releasing Hormone; Insulin-Like Growth Factor I; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurosecretory Systems; Peptide Fragments; Peptides; Pro-Opiomelanocortin; Proglucagon; Proinsulin; Proprotein Convertase 1; Proprotein Convertases; Protein Precursors; Protein Processing, Post-Translational | 2002 |
Glycemic, hormone, and appetite responses to monosaccharide ingestion in patients with type 2 diabetes.
Topics: Adult; Aged; Appetite; Blood Glucose; Diabetes Mellitus, Type 2; Female; Fructose; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Insulin; Male; Middle Aged; Peptide Fragments | 2002 |
Rebuttal to Deacon and Holst: "Metformin effects on dipeptidyl peptidase IV degradation of glucagon-like peptide-1" versus "Dipeptidyl peptidase inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective".
Topics: Animals; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Metformin; Peptide Fragments; Protease Inhibitors; Protein Precursors | 2002 |
Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications.
Topics: Activating Transcription Factor 1; Animals; Cells, Cultured; Cyclic AMP; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dimethyl Sulfoxide; DNA-Binding Proteins; Drug Synergism; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Peptide Fragments; Phosphorylation; Protein Precursors; Rats; Repressor Proteins; Transcription Factors; Transcription, Genetic; Transfection | 2002 |
Local, exendin-(9-39)-insensitive, site of action of GLP-1 in canine ileum.
Topics: Animals; Capsaicin; Dogs; Drug Resistance; Electric Stimulation; Electrophysiology; Female; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Ileum; In Vitro Techniques; Injections, Intra-Arterial; Male; Peptide Fragments; Protein Precursors; Tissue Distribution | 2002 |
Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.
Topics: Animals; Basal Ganglia; Cell Death; Cell Survival; Cells, Cultured; Choline O-Acetyltransferase; Cyclic AMP; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Exenatide; Glial Fibrillary Acidic Protein; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Hippocampus; Ibotenic Acid; Immunohistochemistry; Nerve Degeneration; Neurons; Parasympathetic Nervous System; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Glucagon; Venoms | 2002 |
Defective amplification of the late phase insulin response to glucose by GIP in obese Type II diabetic patients.
Topics: Aged; Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Drug Synergism; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemic Agents; Injections, Intravenous; Insulin; Male; Middle Aged; Obesity; Peptide Fragments; Protein Precursors; Reference Values; Time Factors | 2002 |
Feast or famine - are GLP-1 and ghrelin secretion intertwined?
Topics: Appetite; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Leptin; Peptide Fragments; Peptide Hormones; Protein Precursors; Satiety Response | 2002 |
Cellular specificity of proexendin-4 processing in mammalian cells in vitro and in vivo.
Topics: Adrenocorticotropic Hormone; Animals; Antibody Specificity; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Exenatide; Female; Fibroblasts; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; Islets of Langerhans; Kidney; Male; Mice; Mice, Transgenic; Organ Specificity; Peptide Fragments; Peptides; Pituitary Gland; Protein Precursors; Radioimmunoassay; Reverse Transcriptase Polymerase Chain Reaction; Transfection; Venoms | 2002 |
Functional maturation of fetal porcine beta-cells by glucagon-like peptide 1 and cholecystokinin.
Topics: Animals; Cell Differentiation; Cell Division; Cell Size; Cholecystokinin; Culture Techniques; Fluorescent Antibody Technique; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Niacinamide; Peptide Fragments; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; Swine; Time Factors | 2002 |
Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion.
Topics: Animals; Blotting, Northern; Blotting, Western; Cyclic AMP; Cytomegalovirus; Fluorescent Antibody Technique; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Mice; Microscopy, Fluorescence; Pancreatic Neoplasms; Peptide Fragments; Proglucagon; Promoter Regions, Genetic; Protein Precursors; RNA, Messenger; Signal Transduction; Transfection; Tumor Cells, Cultured | 2002 |
Glucose-sensing in glucagon-like peptide-1-secreting cells.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Cell Line; Cell Membrane; Diazoxide; Electric Conductivity; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Glucose; Glycosyltransferases; Hypoglycemic Agents; Membrane Proteins; Peptide Fragments; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Precursors; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae Proteins; Tolbutamide | 2002 |
Glucagon-like peptide-1 inhibits pancreatic ATP-sensitive potassium channels via a protein kinase A- and ADP-dependent mechanism.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Cell Line; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Molecular Sequence Data; Pancreas; Peptide Fragments; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Precursors; Receptors, Drug; Receptors, Glucagon; Sequence Homology, Amino Acid; Sulfonylurea Receptors | 2002 |
Anti-diabetogenic effect of the human amylin analogue, pramlintide, in Type 1 diabetes is not mediated by GLP-1.
Topics: Adult; Amyloid; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Hypoglycemic Agents; Islet Amyloid Polypeptide; Male; Peptide Fragments; Protein Precursors | 2002 |
The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Cell Division; Diabetes Mellitus, Type 2; Eating; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Hyperglycemia; Insulin; Islets of Langerhans; Liraglutide; Mice; Mice, Inbred C57BL; Mice, Obese; Peptide Fragments; Peptides; Protein Precursors; Venoms | 2002 |
Somatostatin inhibits glucagon-like peptide-1-induced insulin secretion and proliferation of RINm5F insulinoma cells.
Topics: Animals; Cell Division; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Drug Interactions; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Insulinoma; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Somatostatin; Transcription Factors; Tumor Cells, Cultured | 2002 |
NN2211: a long-acting glucagon-like peptide-1 derivative with anti-diabetic effects in glucose-intolerant pigs.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Hypoglycemic Agents; Insulin; Liraglutide; Male; Peptide Fragments; Protein Precursors; Swine, Miniature | 2002 |
Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice.
Topics: Animals; Apoptosis; Blood Glucose; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 1; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hyperglycemia; Insulin; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Peptide Fragments; Peptides; Protein Precursors; Venoms | 2002 |
Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Lipolysis; Male; Peptide Fragments; Phosphofructokinase-2; Protein Precursors; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2003 |
cAMP-dependent protein kinase and Ca2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells.
Topics: Animals; Calcium; Calcium Channels, L-Type; Cell Line; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Ion Transport; Islets of Langerhans; Mice; Mitogen-Activated Protein Kinases; Peptide Fragments; Protein Precursors; Protein Transport; Proto-Oncogene Proteins c-raf | 2002 |
tGLP-1 action on the isolated hypothalamo-neurohypophysial system under glutamate receptor blockade.
Topics: Animals; Arginine Vasopressin; Excitatory Amino Acid Antagonists; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamo-Hypophyseal System; In Vitro Techniques; Male; Oxytocin; Peptide Fragments; Peptides; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Glutamate | 2002 |
Lack of effect of exendin-4 and glucagon-like peptide-1-(7,36)-amide on insulin action in non-diabetic humans.
Topics: Adult; Animals; Biotransformation; Blood Glucose; Body Mass Index; C-Peptide; Dipeptidyl Peptidase 4; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Human Growth Hormone; Humans; Hydrocortisone; Infusions, Intravenous; Insulin; Kinetics; Lizards; Peptide Fragments; Peptides; Reference Values; Venoms | 2002 |
The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge.
Topics: Aspartic Acid; Cell Line; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Mutagenesis, Site-Directed; Peptide Fragments; Protein Precursors; Radioligand Assay; Receptors, Glucagon | 2002 |
Effect of growth hormone on high plasma levels of glucagon-like peptide-1 (GLP-1) in hypophysectomized rats.
Topics: Animals; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Growth Hormone; Hypophysectomy; Insulin; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar | 2002 |
Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Calcium; Cerulenin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Membrane Potentials; Peptide Fragments; Potassium; Protein Precursors; Rats; Rats, Wistar | 2002 |
Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.
Topics: Animals; Apoptosis; Blood Glucose; Caspase 3; Caspases; Cell Division; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; In Situ Nick-End Labeling; Insulin; Insulin Secretion; Islets of Langerhans; Ki-67 Antigen; Kinetics; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Zucker | 2002 |
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.
Topics: Animals; Apoptosis; beta Catenin; Blood Glucose; Cell Line; Cell Survival; Colforsin; Cricetinae; Cycloheximide; Cytokines; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; In Situ Nick-End Labeling; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Peptides; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, Glucagon; Signal Transduction; Streptozocin; Trans-Activators; Venoms | 2003 |
Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Carbachol; Cell Line; Chelating Agents; Cholinergic Agonists; Colforsin; Cyclic AMP; Diazoxide; Egtazic Acid; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Insulin; Insulin Secretion; Islets of Langerhans; Macrocyclic Compounds; Mitochondria; Oxazoles; Peptide Fragments; Protein Precursors; Ryanodine; Ryanodine Receptor Calcium Release Channel; Thionucleotides | 2003 |
Elevated glucagon-like peptide-1-(7-36)-amide, but not glucose, associated with hyperinsulinemic compensation for fat feeding.
Topics: Animals; Blood Glucose; Blotting, Northern; Dietary Fats; Dogs; Fasting; Fatty Acids, Nonesterified; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Hyperinsulinism; Insulin; Insulin Resistance; Islets of Langerhans; Kinetics; Magnetic Resonance Imaging; Male; Obesity; Peptide Fragments; Receptors, Glucagon; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Enhanced secretion of glucagon-like peptide 1 by biguanide compounds.
Topics: Animals; Biguanides; Buformin; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemic Agents; In Vitro Techniques; Male; Metformin; Peptide Fragments; Phenformin; Protease Inhibitors; Protein Precursors; Pyrroles; Rats; Rats, Inbred F344; Valine | 2002 |
Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways.
Topics: alpha-MSH; Animals; Carrier Proteins; Feeding Behavior; Galanin; Glucagon; Glucagon-Like Peptide 1; Injections, Intraventricular; Intracellular Signaling Peptides and Proteins; Leptin; Male; Neuropeptides; Orexin Receptors; Orexins; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Receptors, Neuropeptide Y | 2002 |
Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells.
Topics: beta Catenin; Cell Line; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Humans; Intestinal Mucosa; Lithium; Peptide Fragments; Proglucagon; Promoter Regions, Genetic; Protein Precursors; Trans-Activators; Transcriptional Activation; Transfection | 2003 |
Interaction between specific fatty acids, GLP-1 and insulin secretion in humans.
Topics: Adult; Anticoagulants; Dietary Fats; Fatty Acids, Monounsaturated; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Female; Glucagon; Glucagon-Like Peptide 1; Heparin; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Male; Middle Aged; Peptide Fragments; Protein Precursors; Reference Values | 2002 |
Regulation of the pdx1 gene promoter in pancreatic beta-cells.
Topics: Animals; Cell Line; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeodomain Proteins; Hormones; Islets of Langerhans; Mice; Mice, Transgenic; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Regulatory Sequences, Nucleic Acid; Sequence Deletion; Trans-Activators; Transcriptional Activation | 2002 |
A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro.
Topics: Amino Acid Sequence; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Humans; Kinetics; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Time Factors | 2002 |
The diverse roles of specific GLP-1 receptors in the control of food intake and the response to visceral illness.
Topics: Amygdala; Animals; Anorexia; Appetite Regulation; Behavior, Animal; Catheterization; Conditioning, Psychological; Dose-Response Relationship, Drug; Eating; Fourth Ventricle; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intraperitoneal; Injections, Intraventricular; Lateral Ventricles; Lithium Chloride; Male; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Rats; Rats, Long-Evans; Receptors, Glucagon; Signal Transduction; Taste; Visceral Afferents | 2002 |
cAMP-activated protein kinase-independent potentiation of insulin secretion by cAMP is impaired in SUR1 null islets.
Topics: Animals; ATP-Binding Cassette Transporters; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Mice; Mice, Knockout; Peptide Fragments; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Kinase C; Pyrroles; Receptors, Drug; Reference Values; Sulfonamides; Sulfonylurea Receptors | 2002 |
Theratechnologies expands peptide portfolio in endocrinology.
Topics: Administration, Cutaneous; Clinical Trials, Phase II as Topic; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Peptide Fragments; Protein Precursors | 2002 |
Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1.
Topics: Animals; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Flow Cytometry; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Glucose; Glucose Transporter Type 2; Humans; Immunohistochemistry; Insulin; Insulin Secretion; Monosaccharide Transport Proteins; Pancreatic Ducts; Peptide Fragments; Protein Precursors; Rats; Tumor Suppressor Proteins | 2002 |
The vagus is inhibitory of the late postprandial insulin secretion in conscious pigs.
Topics: Analysis of Variance; Animals; Area Under Curve; Blood Glucose; Consciousness; Female; Food; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Peptide Fragments; Postprandial Period; Protein Precursors; Radioimmunoassay; Stomach; Swine; Time Factors; Vagotomy; Vagus Nerve | 2002 |
Involvement of the ryanodine-sensitive Ca2+ store in GLP-1-induced Ca2+ oscillations in insulin-secreting HIT cells.
Topics: Calcium; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Microscopy, Confocal; Microscopy, Electron, Scanning; Oscillometry; Osmolar Concentration; Peptide Fragments; Protein Precursors; Ryanodine Receptor Calcium Release Channel | 2002 |
The effects of duodenal peptides on glucagon-like peptide-1 secretion from the ileum. A duodeno--ileal loop?
Topics: Animals; Calcitonin Gene-Related Peptide; Chemotherapy, Cancer, Regional Perfusion; Duodenum; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Ileum; Motilin; Peptide Fragments; Postprandial Period; Protein Precursors; Sincalide; Swine | 2002 |
Comparative peptidomics of the endocrine pancreas: islet hormones from the clawed frog Xenopus laevis and the red-bellied newt Cynops pyrrhogaster.
Topics: Amino Acid Sequence; Amphibians; Animals; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Insulin; Islets of Langerhans; Molecular Sequence Data; Pancreatic Hormones; Pancreatic Polypeptide; Peptide Fragments; Peptides; Protein Precursors; Salamandridae; Sequence Analysis, Protein; Spectrometry, Mass, Electrospray Ionization; Xenopus laevis | 2002 |
Trafficking of mutant carboxypeptidase E to secretory granules in a beta-cell line derived from Cpe(fat)/Cpe(fat) mice.
Topics: Animals; Blotting, Western; Carboxypeptidase H; Carboxypeptidases; Cell Line; Enzyme Precursors; Enzyme Stability; Fluorescent Antibody Technique, Indirect; Glucagon; Glucagon-Like Peptide 1; Half-Life; Islets of Langerhans; Mice; Microscopy, Fluorescence; Mutation; Peptide Fragments; Proprotein Convertase 2; Protein Precursors; Secretory Vesicles; Subtilisins | 2003 |
Glucagon-like peptide-1 evokes action potentials and increases cytosolic Ca2+ in rat nodose ganglion neurons.
Topics: Action Potentials; Animals; Calcium; Cytosol; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Male; Membrane Potentials; Neurons; Nodose Ganglion; Patch-Clamp Techniques; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar | 2002 |
Glucagon-like peptide 1 induces pancreatic beta-cell proliferation via transactivation of the epidermal growth factor receptor.
Topics: Animals; Antibodies; Betacellulin; Cell Division; Cell Line; Coculture Techniques; CSK Tyrosine-Protein Kinase; Dipeptides; ErbB Receptors; Genes, Dominant; Glucagon; Glucagon-Like Peptide 1; Humans; Intercellular Signaling Peptides and Proteins; Islets of Langerhans; Male; Peptide Fragments; Prostatic Neoplasms; Protein Precursors; Protein-Tyrosine Kinases; Rats; Rats, Wistar; src-Family Kinases; Transcriptional Activation | 2003 |
Decreased glucagon-like peptide 1 fasting levels in type 2 diabetes.
Topics: Aged; Diabetes Mellitus, Type 2; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Peptide Fragments; Protein Precursors | 2003 |
Cooperative enhancement of insulinotropic action of GLP-1 by acetylcholine uncovers paradoxical inhibitory effect of beta cell muscarinic receptor activation on adenylate cyclase activity.
Topics: Acetylcholine; Adenylyl Cyclases; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors; Receptors, Muscarinic | 2003 |
Comparisons of leptin, incretins and body composition in obese and lean patients with hypopituitarism and healthy individuals.
Topics: Adult; Anthropometry; Body Composition; Case-Control Studies; Cross-Sectional Studies; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Human Growth Hormone; Humans; Hypopituitarism; Leptin; Lipids; Male; Middle Aged; Obesity; Peptide Fragments; Peptides; Thinness | 2003 |
Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects.
Topics: Aged; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Injections, Intravenous; Male; Middle Aged; Obesity; Osmolar Concentration; Peptide Fragments; Protein Precursors; Reference Values | 2003 |
The isolated N-terminal domain of the glucagon-like peptide-1 (GLP-1) receptor binds exendin peptides with much higher affinity than GLP-1.
Topics: Amino Acid Sequence; Binding, Competitive; Cell Line; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Recombinant Proteins; Venoms | 2003 |
Enteroinsular axis of db/db mice and efficacy of dipeptidyl peptidase IV inhibition.
Topics: Actins; Aging; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Proglucagon; Protease Inhibitors; Protein Precursors; Pyrroles; Valine | 2003 |
Effects of tGLP-1 on feeding behaviour and neurohypophysial function under chronic osmotic stimulation.
Topics: Animals; Arginine Vasopressin; Drinking; Eating; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Hematocrit; Injections, Intraventricular; Male; Osmolar Concentration; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Saline Solution, Hypertonic | 2003 |
Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis.
Topics: Adaptation, Physiological; Animals; Arginine; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Immunohistochemistry; In Vitro Techniques; Insulin; Intestines; Intracellular Membranes; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreas; Peptide Fragments; Protein Precursors; Receptors, Gastrointestinal Hormone; RNA, Messenger | 2003 |
Role of leptin in the regulation of glucagon-like peptide-1 secretion.
Topics: Animals; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Leptin; Peptide Fragments; Protein Precursors; Rats; Tetradecanoylphorbol Acetate | 2003 |
Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy.
Topics: Animals; Blood Glucose; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Homeostasis; Hyperglycemia; Islets of Langerhans; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Pancreatectomy; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Regeneration; Time Factors | 2003 |
The influence of GLP-1 on glucose-stimulated insulin secretion: effects on beta-cell sensitivity in type 2 and nondiabetic subjects.
Topics: Area Under Curve; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Protein Precursors; Reference Values | 2003 |
A tumour that secretes glucagon-like peptide-1 and somatostatin in a patient with reactive hypoglycaemia and diabetes.
Topics: Blood Glucose; Carcinoid Tumor; Diabetes Complications; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Hypoglycemia; Hysterectomy; Middle Aged; Ovarian Neoplasms; Peptide Fragments; Protein Precursors; Somatostatin | 2003 |
Pharmacologic treatment of type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Exenatide; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Monosaccharide Transport Proteins; Obesity; Peptide Fragments; Peptide Hormones; Peptides; Peroxisome Proliferators; Protein Precursors; Receptors, Cell Surface; Thiazoles; Venoms | 2003 |
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin | 2003 |
Effect of intraportal glucagon-like peptide-1 on glucose metabolism in conscious dogs.
Topics: Alanine; Animals; Blood Glucose; Cardiovascular System; Dogs; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycerol; Glycogen; Hormones; Infusions, Intravenous; Lactic Acid; Liver; Liver Circulation; Osmolar Concentration; Peptide Fragments; Portal Vein; Protein Precursors | 2003 |
Genetic analysis of Caenorhabditis elegans glp-1 mutants suggests receptor interaction or competition.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; DNA-Binding Proteins; Glucagon; Glucagon-Like Peptide 1; Membrane Proteins; Mutation; Peptide Fragments; Protein Precursors; Receptors, Notch; Signal Transduction | 2003 |
SUR1 regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.
Topics: Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electric Capacitance; Electrophysiology; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Guanine Nucleotide Exchange Factors; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Mice, Knockout; Peptide Fragments; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Precursors; Receptors, Drug; Secretory Vesicles; Sulfonylurea Receptors; Time Factors | 2003 |
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cell Count; Cell Differentiation; Cell Division; Cell Survival; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Eating; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Lipids; Liver; Male; Peptide Fragments; Phosphoenolpyruvate Carboxykinase (GTP); Protease Inhibitors; Protein Precursors; Rats; Rats, Wistar; Weight Gain | 2003 |
Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo.
Topics: Animals; Blood Glucose; Body Weight; CHO Cells; Cricetinae; Cyclic AMP; Diabetes Mellitus; Dipeptidyl Peptidase 4; Fibroblasts; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Maleimides; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Peptides; Proinsulin; Protein Precursors; Receptors, Glucagon; Recombinant Proteins; RNA, Messenger; Serum Albumin; Transfection | 2003 |
Glucagon-like peptide-1 inhibits glucagon-induced glycogenolysis in perivenous hepatocytes specifically.
Topics: Animals; Cell Separation; Digitonin; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Gluconeogenesis; Hepatic Veins; Hepatocytes; Insulin; Liver Glycogen; Male; Microbial Collagenase; Microcirculation; Peptide Fragments; Protein Precursors; Radioligand Assay; Rats; Rats, Wistar | 2003 |
Glucagon-like peptide 1 content of intestinal tract in adult rats injected with streptozotocin either during neonatal period or 7 d before sacrifice.
Topics: Animals; Animals, Newborn; Blood Glucose; Body Weight; Cecum; Colon; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Ileum; Insulin; Intestines; Jejunum; Male; Pancreas; Peptide Fragments; Protein Precursors; Proteins; Rats; Rats, Inbred BB; Rats, Wistar; Streptozocin | 2002 |
Mechanisms involved in glucagon-like peptide-1 (7-36) amide action on the rat hypothalamo-neurohypophysial system.
Topics: Analysis of Variance; Angiotensin II; Animals; Calcium; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamo-Hypophyseal System; Male; Neurotransmitter Agents; Organ Culture Techniques; Oxytocin; Peptide Fragments; Rats; Rats, Wistar; Second Messenger Systems; Vasopressins; Water-Electrolyte Balance | 2003 |
Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Cyclic AMP; Diabetes Mellitus; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hyperinsulinism; Insulin; Insulin Secretion; Mice; Obesity; Peptide Fragments; Postprandial Period; Protein Precursors; Spectrometry, Mass, Electrospray Ionization | 2003 |
Effects of glucagon-like peptide-1 (7-36) amide on neurohypophysial hormone secretion induced by acute hyperosmotic challenge.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Hypertonic Solutions; Injections, Intraperitoneal; Injections, Intraventricular; Male; Osmotic Pressure; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Pituitary Hormones, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Vasopressins | 2003 |
Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5'-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway.
Topics: Animals; Apoptosis; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Glucagon; Glucagon-Like Peptide 1; Hydrogen Peroxide; Insulinoma; Islets of Langerhans; Mice; Oxidants; Peptide Fragments; Phosphatidylinositol 3-Kinases; Poly(ADP-ribose) Polymerases; Protein Precursors; Signal Transduction; Tumor Cells, Cultured | 2003 |
The intriguing diversity of the glucagon gene products.
Topics: Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Multigene Family; Peptide Fragments; Peptides; Protein Precursors | 2002 |
Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
Topics: Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glyburide; Humans; Islets of Langerhans; Isoquinolines; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-raf; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Sulfonamides; Verapamil | 2003 |
Total parenteral nutrition-stimulated activity of inducible nitric oxide synthase in rat pancreatic islets is suppressed by glucagon-like peptide-1.
Topics: Animals; Cyclic AMP; Cyclic GMP; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Islets of Langerhans; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Parenteral Nutrition, Total; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 2003 |
Effects of GLP-1-(7-36)NH2, GLP-1-(7-37), and GLP-1- (9-36)NH2 on intravenous glucose tolerance and glucose-induced insulin secretion in healthy humans.
Topics: Adult; Blood Glucose; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Kinetics; Male; Middle Aged; Peptide Fragments; Peptides; Protein Precursors | 2003 |
Glucagon-like peptide-1-responsive catecholamine neurons in the area postrema link peripheral glucagon-like peptide-1 with central autonomic control sites.
Topics: Animals; Area Postrema; Autonomic Pathways; Catecholamines; Cell Line; Central Nervous System; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Immunohistochemistry; In Situ Hybridization; Male; Neurons; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; RNA, Messenger; Solitary Nucleus; Transcriptional Activation; Tyrosine 3-Monooxygenase; Venoms | 2003 |
Aberrant regulation of human intestinal proglucagon gene expression in the NCI-H716 cell line.
Topics: Adenocarcinoma; Animals; Butyrates; Cecal Neoplasms; Gene Expression; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Humans; Intestines; Nuclear Proteins; Peptide Fragments; Proglucagon; Protein Precursors; Rats; Transcription Factors; Tumor Cells, Cultured | 2003 |
Glucagon-like peptide 1 (1-37) converts intestinal epithelial cells into insulin-producing cells.
Topics: Animals; Base Sequence; Cells, Cultured; DNA Primers; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Peptides; Pregnancy; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Gastric distension induces c-Fos in medullary GLP-1/2-containing neurons.
Topics: Animals; Appetite Regulation; Gastric Dilatation; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Male; Neurons; Peptide Fragments; Peptides; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Solitary Nucleus | 2003 |
A novel glucose-sensing mechanism contributing to glucagon-like peptide-1 secretion from the GLUTag cell line.
Topics: Animals; Carbohydrates; Cell Line; Fructose; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glyburide; Hypoglycemic Agents; Islets of Langerhans; Kinetics; Mannitol; Mice; Monosaccharide Transport Proteins; Peptide Fragments; Phlorhizin; Protein Precursors | 2003 |
GLP-1 gene delivery for the treatment of type 2 diabetes.
Topics: Animals; Blood Glucose; Cell Culture Techniques; Cell Line; Diabetes Mellitus, Type 2; Genetic Vectors; Glucagon; Glucagon-Like Peptide 1; Injections, Intravenous; Islets of Langerhans; Peptide Fragments; Plasmids; Protein Precursors; Rats | 2003 |
Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Cell Death; Down-Regulation; Exenatide; Fetus; Glucagon; Glucagon-Like Peptide 1; Hippocampus; Iron; Male; Mice; Mice, Inbred Strains; Neurons; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Venoms | 2003 |
Peptides that regulate food intake: glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats.
Topics: Animals; Dose-Response Relationship, Drug; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamic Area, Lateral; Hypothalamus, Middle; Male; Peptide Fragments; Rats; Rats, Wistar; Time Factors | 2003 |
GLP-1 stimulates glucose-derived de novo fatty acid synthesis and chain elongation during cell differentiation and insulin release.
Topics: Animals; Carbon Isotopes; Cell Differentiation; Cell Line, Tumor; Chromatography, High Pressure Liquid; Epithelial Cells; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Pancreas; Peptide Fragments; Protein Precursors; Rats | 2003 |
Anti-hypertensive and natriuretic effect of glucagon-like peptide 1 in Dahl S rats: a novel function for a pleotrophic hormone?
Topics: Animals; Blood Pressure; Glucagon; Glucagon-Like Peptide 1; Hypertension; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Dahl | 2003 |
Antihypertensive effect of glucagon-like peptide 1 in Dahl salt-sensitive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Glucose; Diuresis; Endothelium, Vascular; Glucagon; Glucagon-Like Peptide 1; Heart Diseases; Hypertension; Insulin; Kidney Diseases; Male; Natriuresis; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Dahl; Sodium; Sodium Chloride, Dietary; Water-Electrolyte Balance | 2003 |
Incretin secretion in relation to meal size and body weight in healthy subjects and people with type 1 and type 2 diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Body Weight; C-Peptide; Case-Control Studies; Diabetes Mellitus; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Feeding Behavior; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Middle Aged; Obesity; Peptide Fragments; Protein Precursors; Random Allocation | 2003 |
Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells.
Topics: Adult; Cell Line; Enteroendocrine Cells; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Peptide Fragments; Protein Precursors; Receptor, Muscarinic M1; Receptor, Muscarinic M2; Receptor, Muscarinic M3; Receptors, Muscarinic | 2003 |
Central, but not peripheral, glucagon-like peptide-1 inhibits crop emptying in chicks.
Topics: Animals; Chickens; Crop, Avian; Glucagon; Glucagon-Like Peptide 1; Injections, Intraperitoneal; Injections, Intraventricular; Peptide Fragments; Protein Precursors | 2003 |
Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects.
Topics: Adult; Blood Glucose; C-Peptide; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Male; Peptide Fragments; Postprandial Period; Protein Precursors; Reference Values | 2003 |
GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine.
Topics: Animals; Chromatography, Gel; Endocrine Glands; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; In Situ Hybridization; Intestine, Small; Peptide Fragments; Protein Precursors; Swine | 2003 |
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Diabetes Mellitus; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Islets of Langerhans; Mice; Mice, Transgenic; Peptide Fragments; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Transfection; Transgenes; Tumor Cells, Cultured | 2003 |
Effects of glucagon-like peptide-1 and feeding on gastric volumes in diabetes mellitus with cardio-vagal dysfunction.
Topics: Aged; Cross-Over Studies; Diabetes Mellitus; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Heart Rate; Humans; Male; Middle Aged; Peptide Fragments; Postprandial Period; Protein Precursors; Stomach; Tomography, Emission-Computed, Single-Photon; Vagus Nerve Diseases | 2003 |
Cell signalling of the GLP-1 action in rat liver.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glycogen Synthase; Hepatocytes; Insulin; Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Protein Kinase C; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction | 2003 |
Glucagon-like peptide-1 (7-36) amide prevents the accumulation of pyruvate and lactate in the ischemic and non-ischemic porcine myocardium.
Topics: Animals; Area Under Curve; Blood Glucose; Cardiovascular System; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Ischemia; Lactic Acid; Microdialysis; Myocardial Infarction; Myocardium; Peptide Fragments; Protein Precursors; Pyruvic Acid; Reperfusion Injury; Swine; Time Factors | 2003 |
Glucose-dependent insulinotropic peptide stimulates proliferation and TGF-beta release from MG-63 cells.
Topics: Alkaline Phosphatase; Blotting, Northern; Cell Differentiation; Cell Division; Cell Line, Tumor; Collagen; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Insulin; Osteoblasts; Peptide Fragments; Peptides; RNA; Thymidine; Transforming Growth Factor beta | 2003 |
CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors.
Topics: Adrenocorticotropic Hormone; Amygdala; Animals; Anxiety; Brain; Catheterization; Central Nervous System; Corticosterone; Corticotropin-Releasing Hormone; Dose-Response Relationship, Drug; Drug Administration Routes; Endocrine System; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Hypothalamo-Hypophyseal System; Male; Neuroprotective Agents; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Pituitary-Adrenal System; Rats; Rats, Long-Evans; Receptors, Corticotropin-Releasing Hormone; Receptors, Glucagon; Stress, Psychological | 2003 |
Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets.
Topics: Animals; Carrier Proteins; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Hypothalamic Hormones; In Vitro Techniques; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; Islets of Langerhans; Melanins; Nerve Tissue Proteins; Neuropeptides; Orexin Receptors; Orexins; Peptide Fragments; Peptide Hormones; Pituitary Hormones; Protein Precursors; Rats; Receptors, G-Protein-Coupled; Receptors, Ghrelin; Receptors, Neuropeptide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2003 |
Glucagon-like peptide-1 receptor is involved in learning and neuroprotection.
Topics: Administration, Intranasal; Amino Acid Sequence; Animals; Apoptosis; Behavior, Animal; Cognition; Gene Expression; Gene Transfer Techniques; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hippocampus; Kainic Acid; Learning; Male; Mice; Mice, Knockout; Molecular Sequence Data; Neurons; Neuroprotective Agents; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Seizures; Sequence Homology, Amino Acid; Signal Transduction | 2003 |
Learning from the gut.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamic Acid; Insulin; Insulin Secretion; Learning; Memory; Mice; Nerve Degeneration; Neuronal Plasticity; Pancreas; Peptide Fragments; Protein Precursors; Rats; Receptors, Neurotransmitter; Signal Transduction | 2003 |
Regulation of glucagon-like peptide-1 receptor and calcium-sensing receptor signaling by L-histidine.
Topics: Animals; Calcium; Cell Line; Cyclic AMP; Extracellular Fluid; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Histidine; Humans; Osmolar Concentration; Peptide Fragments; Pertussis Toxin; Protein Precursors; Rats; Receptors, Calcium-Sensing; Receptors, Glucagon; Response Elements; RNA; Signal Transduction | 2003 |
Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets.
Topics: Apoptosis; Caspase 3; Caspases; Cell Survival; Cells, Cultured; Fluorescent Antibody Technique; Fluorescent Dyes; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; In Vitro Techniques; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2003 |
Glucagon like peptide-1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus.
Topics: Animals; Corticotropin-Releasing Hormone; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; Male; Microscopy, Immunoelectron; Neurons; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Presynaptic Terminals; Protein Precursors; Rats; Rats, Sprague-Dawley | 2003 |
GLP-1 derivative liraglutide in rats with beta-cell deficiencies: influence of metabolic state on beta-cell mass dynamics.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Insulin; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Rats, Zucker | 2003 |
A model for receptor-peptide binding at the glucagon-like peptide-1 (GLP-1) receptor through the analysis of truncated ligands and receptors.
Topics: Amino Acid Sequence; Cell Line; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Kinetics; Ligands; Models, Biological; Molecular Sequence Data; Peptide Fragments; Peptides; Plasmids; Protein Binding; Protein Precursors; Receptors, Glucagon; Sequence Homology, Amino Acid; Transfection; Venoms | 2003 |
Glucagon-like peptide 1 receptor agonist ZP10A increases insulin mRNA expression and prevents diabetic progression in db/db mice.
Topics: Animals; Blood Glucose; Carrier Proteins; Diabetes Mellitus; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred C57BL; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; RNA, Messenger | 2003 |
Type VIII adenylyl cyclase in rat beta cells: coincidence signal detector/generator for glucose and GLP-1.
Topics: Adenylyl Cyclases; Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calmodulin; Cells, Cultured; Cyclic AMP; Drug Combinations; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; GTP-Binding Protein alpha Subunits, Gs; Insulin; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Signal Transduction; Verapamil | 2003 |
Lower glucose-dependent insulinotropic polypeptide (GIP) response but similar glucagon-like peptide 1 (GLP-1), glycaemic, and insulinaemic response to ancient wheat compared to modern wheat depends on processing.
Topics: Adult; Area Under Curve; Blood Glucose; Bread; Food Handling; Gastric Inhibitory Polypeptide; Gastrointestinal Agents; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Peptide Fragments; Postprandial Period; Protein Precursors; Triticum | 2003 |
Glucagon-like peptide-1 induces a cAMP-dependent increase of [Na+]i associated with insulin secretion in pancreatic beta-cells.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Animals; Calcium; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gadolinium; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Male; Mesocricetus; Ouabain; Peptide Fragments; Protein Precursors; Sodium; Somatostatin; Sulfonamides; Tetrodotoxin | 2003 |
Antagonism of rat beta-cell voltage-dependent K+ currents by exendin 4 requires dual activation of the cAMP/protein kinase A and phosphatidylinositol 3-kinase signaling pathways.
Topics: Androstadienes; Animals; Blotting, Western; Catalysis; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activation; Enzyme Inhibitors; ErbB Receptors; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Kinetics; Male; Mice; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphorylation; Potassium; Precipitin Tests; Protein Precursors; Quinazolines; Rats; Rats, Wistar; Signal Transduction; Time Factors; Transcriptional Activation; Tyrphostins; Up-Regulation; Venoms; Wortmannin | 2003 |
Racial differences in glucagon-like peptide-1 (GLP-1) concentrations and insulin dynamics during oral glucose tolerance test in obese subjects.
Topics: Adult; Anthropometry; Black or African American; Body Composition; Body Mass Index; Energy Intake; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Male; Obesity; Peptide Fragments; Protein Precursors | 2003 |
[Ser2]- and [SerP2] incretin analogs: comparison of dipeptidyl peptidase IV resistance and biological activities in vitro and in vivo.
Topics: Animals; Blood Glucose; CHO Cells; Cricetinae; Cyclic AMP; Dipeptidyl Peptidase 4; Drug Stability; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; In Vitro Techniques; Male; Peptide Fragments; Phosphoserine; Protein Precursors; Rats; Rats, Wistar; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Serine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Glucagon-like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons.
Topics: Animals; Calcium; Calcium Channels; Cell Death; Cell Membrane; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glutamic Acid; Hippocampus; Neurons; Neuroprotective Agents; Neurotoxins; Patch-Clamp Techniques; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 2003 |
Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Immunohistochemistry; Intestines; Mice; Mice, Mutant Strains; Pancreas; Peptide Fragments; Peptides; Proglucagon; Proprotein Convertase 1; Protein Precursors | 2004 |
Novel dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1(7-36)amide have preserved biological activities in vitro conferring improved glucose-lowering action in vivo.
Topics: Amino Acid Substitution; Animals; Cells, Cultured; Cricetinae; Cyclic AMP; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzymes; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Insulin Secretion; Mice; Mice, Obese; Peptide Fragments; Receptors, Glucagon; Spectrometry, Mass, Electrospray Ionization | 2003 |
The endocrine pancreas in non-diabetic rats after short-term and long-term treatment with the long-acting GLP-1 derivative NN2211.
Topics: Animals; Body Weight; Cell Count; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Liraglutide; Male; Organ Size; Rats; Rats, Sprague-Dawley; Time Factors | 2003 |
Drug discovery and development for metabolic diseases.
Topics: Adult; Animals; Appetite; Child; Congresses as Topic; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Obesity; Peptide Fragments; Peptide YY; Pharmacology, Clinical; Protein Precursors; Receptors, Glucocorticoid | 2003 |
Endo-neuro-endocrine incretin pathways.
Topics: Animals; Endocrine Glands; Glucagon; Glucagon-Like Peptide 1; Humans; Neurosecretory Systems; Peptide Fragments; Protein Precursors | 2004 |
Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice.
Topics: Animals; Animals, Newborn; Capsaicin; Denervation; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; In Vitro Techniques; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Neurons, Afferent; Peptide Fragments; Protein Precursors | 2004 |
Metabolic stability, receptor binding, cAMP generation, insulin secretion and antihyperglycaemic activity of novel N-terminal Glu9-substituted analogues of glucagon-like peptide-1.
Topics: Adenosine Deaminase; Amino Acid Substitution; Animals; Binding, Competitive; Blood Glucose; Cell Line, Tumor; Cricetinae; Cyclic AMP; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Fibroblasts; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glutamine; Glycoproteins; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Obese; Peptide Fragments; Phenylalanine; Proline; Protein Precursors; Rats; Receptors, Glucagon; Spectrometry, Mass, Electrospray Ionization; Transformation, Genetic; Tyrosine | 2003 |
Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme.
Topics: Adenosine Deaminase; Amino Acid Sequence; Animals; Base Sequence; Catalytic Domain; Cloning, Molecular; Dipeptides; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Fluorescent Dyes; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glycoproteins; Humans; Isoelectric Point; Kidney; Kinetics; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Peptides; Pichia; Protein Binding; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Swine | 2003 |
The hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 in chicks.
Topics: Animals; Anorexia; Chickens; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Hypothalamus; Injections, Intraventricular; Male; Peptide Fragments; Protein Precursors; Proto-Oncogene Proteins c-fos; Ventromedial Hypothalamic Nucleus | 2004 |
Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration.
Topics: Administration, Intranasal; Animals; Autoradiography; Brain; Glucagon; Glucagon-Like Peptide 1; Iodine Radioisotopes; Male; Mice; Olfactory Bulb; Peptide Fragments; Protein Precursors; Tissue Distribution | 2004 |
Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; ATP-Binding Cassette Transporters; Blood Glucose; Calcium; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Intracellular Fluid; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Peptide Fragments; Phosphodiesterase Inhibitors; Potassium Channels, Inwardly Rectifying; Protein Precursors; Receptors, Drug; Second Messenger Systems; Signal Transduction; Sulfonylurea Receptors | 2004 |
Beta-cell-targeted overexpression of phosphodiesterase 3B in mice causes impaired insulin secretion, glucose intolerance, and deranged islet morphology.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Blotting, Western; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; DNA, Complementary; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred CBA; Mice, Transgenic; Microscopy, Fluorescence; Peptide Fragments; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2004 |
Glucagon-like peptide-1 secretion is influenced by perfusate glucose concentration and by a feedback mechanism involving somatostatin in isolated perfused porcine ileum.
Topics: Animals; Feedback, Physiological; Gastric Inhibitory Polypeptide; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucose; Ileum; In Vitro Techniques; Insulin; Peptide Fragments; Peptide YY; Peptides; Perfusion; Pressure; Protein Precursors; Somatostatin; Swine | 2004 |
Effects of intracerebroventricularly injected glucagon-like peptide-1 on cardiovascular parameters; role of central cholinergic system and vasopressin.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Antihypertensive Agents; Blood Pressure; Central Nervous System; Cholinergic Fibers; Glucagon; Glucagon-Like Peptide 1; Heart Rate; Injections, Intraventricular; Male; Mecamylamine; Muscarinic Antagonists; Nicotinic Antagonists; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Muscarinic; Receptors, Vasopressin; Time Factors; Vasopressins | 2004 |
N-acetyl-GLP-1: a DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic beta-cell-associated gene expression.
Topics: Animals; Base Sequence; Cell Differentiation; Cell Line, Tumor; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Molecular Sequence Data; Pancreatic Ducts; Peptide Fragments; Rats | 2004 |
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.
Topics: Animals; Apoptosis; Cell Division; Cell Line; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine | 2004 |
Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).
Topics: Adenylyl Cyclases; Amino Acid Substitution; Animals; Blood Glucose; Cells, Cultured; Cricetinae; Cyclic AMP; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Fibroblasts; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glutamic Acid; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Lung; Lysine; Mice; Mice, Obese; Peptide Fragments; Peptides; Receptors, Glucagon; Spectrometry, Mass, Electrospray Ionization | 2004 |
Hormonal changes after Roux-en Y gastric bypass for morbid obesity and the control of type-II diabetes mellitus.
Topics: Adult; Anastomosis, Roux-en-Y; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Hydrocortisone; Insulin; Male; Middle Aged; Obesity, Morbid; Peptide Fragments; Protein Precursors | 2004 |
The primary ligand-binding interaction at the GLP-1 receptor is via the putative helix of the peptide agonists.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cell Membrane; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Inhibitory Concentration 50; Ligands; Models, Biological; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Rats; Receptors, Glucagon; Venoms | 2004 |
Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues.
Topics: Amino Acid Sequence; Animals; Cell Line; Cyclic AMP; Exenatide; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Inhibitory Concentration 50; Ligands; Methionine; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Precursors; Rats; Receptors, Glucagon; Sequence Alignment; Sequence Deletion; Tyrosine; Venoms | 2004 |
Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors.
Topics: Animals; Blood Glucose; Carbachol; Cyclic AMP; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Male; Mice; Mice, Knockout; Pancreas; Peptide Fragments; Protein Precursors; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 2004 |
Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.
Topics: Analysis of Variance; Creatinine; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Kinetics; Male; Middle Aged; Patient Selection; Peptide Fragments; Protein Precursors; Reference Values; Renal Insufficiency | 2004 |
Peripheral oxyntomodulin reduces food intake and body weight gain in rats.
Topics: Animals; Appetite Depressants; Arcuate Nucleus of Hypothalamus; Darkness; Dose-Response Relationship, Drug; Drug Administration Schedule; Eating; Fasting; Gastric Emptying; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Immunohistochemistry; Injections; Injections, Intraperitoneal; Male; Oxyntomodulin; Peptide Fragments; Peptide Hormones; Photoperiod; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Weight Gain | 2004 |
N-terminal His(7)-modification of glucagon-like peptide-1(7-36) amide generates dipeptidyl peptidase IV-stable analogues with potent antihyperglycaemic activity.
Topics: Animals; Cell Line, Transformed; Cricetinae; Cyclic AMP; Diabetes Mellitus; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypoglycemic Agents; Insulin; Mesocricetus; Mice; Mice, Obese; Peptide Fragments; Protein Precursors; Pyrrolidonecarboxylic Acid | 2004 |
Cell signalling of glucagon-like peptide-1 action in rat skeletal muscle.
Topics: Androstadienes; Animals; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glycogen Synthase; In Vitro Techniques; Indoles; Insulin; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Okadaic Acid; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Tumor Necrosis Factor-alpha; Wortmannin | 2004 |
Simultaneous determination of incretin hormones and their truncated forms from human plasma by immunoprecipitation and liquid chromatography-mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Mass Spectrometry; Peptide Fragments; Precipitin Tests; Sensitivity and Specificity | 2004 |
Insulin-independent effects of GLP-1 on canine liver glucose metabolism: duration of infusion and involvement of hepatoportal region.
Topics: Animals; Blood Glucose; Dogs; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Infusions, Intravenous; Insulin; Insulin Resistance; Liver; Male; Metabolic Clearance Rate; Peptide Fragments; Portal System; Protein Precursors | 2004 |
Effect of GLP-1 (glucagon-like peptide 1:7-36 amide) on porcine pancreatic endocrine cell proliferation and insulin secretion.
Topics: Animals; Cell Proliferation; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Potassium; RNA, Messenger; Swine | 2004 |
Bioactive GLP-1 in gut, receptor expression in pancreas, and insulin response to GLP-1 in diabetes-prone rats.
Topics: Animals; Blood Glucose; Blotting, Northern; Diabetes Mellitus, Type 1; Female; Gastrointestinal Tract; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Immunohistochemistry; Insulin; Male; Pancreas; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred BB; Receptors, Glucagon | 2004 |
Multi-pathway control of the proliferation versus meiotic development decision in the Caenorhabditis elegans germline.
Topics: Animals; Biomarkers; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Division; Germ Cells; Glucagon; Glucagon-Like Peptide 1; Meiosis; Mitosis; Neoplasms; Peptide Fragments; Phosphoproteins; Protein Precursors; Schizosaccharomyces pombe Proteins; Signal Transduction | 2004 |
Elevated fasting plasma ghrelin in prader-willi syndrome adults is not solely explained by their reduced visceral adiposity and insulin resistance.
Topics: Adipose Tissue; Adult; Case-Control Studies; Fasting; Female; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Male; Middle Aged; Peptide Fragments; Peptide Hormones; Prader-Willi Syndrome; Protein Precursors; Regression Analysis; Viscera | 2004 |
Leptin reduces glucose transport and cellular ATP levels in INS-1 beta-cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 2; Hepatocytes; Humans; Islets of Langerhans; Leptin; Male; Monosaccharide Transport Proteins; Peptide Fragments; Phosphorylation; Potassium Channels; Protein Precursors; Rats; Rats, Sprague-Dawley | 2004 |
Upper gastrointestinal responses to intraduodenal nutrient in type 1 diabetes mellitus.
Topics: Adult; Autonomic Nervous System; Blood Glucose; Diabetes Mellitus, Type 1; Duodenum; Eating; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Male; Manometry; Middle Aged; Parenteral Nutrition; Peptide Fragments; Pressure; Protein Precursors; Pyloric Antrum | 2004 |
Importance of orexigenic counter-regulation for multiple targeted feeding inhibition.
Topics: Animals; Appetite Depressants; Eating; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Male; Naloxone; Narcotic Antagonists; Neuropeptide Y; Neuropeptides; Neurotensin; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Neuropeptide Y | 2004 |
Effect of GIP, GLP-1, insulin and gastrin on ghrelin release in the isolated rat stomach.
Topics: Animals; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Gastric Mucosa; Gastrins; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Male; Peptide Fragments; Peptide Hormones; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Somatostatin; Time Factors | 2004 |
Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.
Topics: Apoptosis; Cell Line; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Humans; Islets of Langerhans; NF-kappa B; Nitriles; Palmitic Acid; Peptide Fragments; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sulfones | 2004 |
Degradation, receptor binding, insulin secreting and antihyperglycaemic actions of palmitate-derivatised native and Ala8-substituted GLP-1 analogues.
Topics: Alanine; Animals; Blood Glucose; Cell Line; Cricetinae; Cricetulus; Cyclic AMP; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Injections, Intraperitoneal; Insulin; Insulin Secretion; Islets of Langerhans; Lysine; Mice; Mice, Obese; Palmitates; Peptide Fragments; Protein Precursors; Radioligand Assay; Receptors, Glucagon; Valine | 2004 |
A gut response. The next generation of type 2 drugs.
Topics: Diabetes Mellitus, Type 2; Exenatide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hypoglycemic Agents; Peptide Fragments; Peptide Hormones; Peptide YY; Peptides; Protein Precursors; United States; Venoms | 2004 |
Typical Danish Caucasian type 2 diabetic patients do not commonly carry genetic variants in GIP and GLP-1 encoding regions of the proGIP and proglucagon genes.
Topics: Aged; Base Sequence; Denmark; Diabetes Mellitus, Type 2; DNA; Female; Gastric Inhibitory Polypeptide; Genetic Predisposition to Disease; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Male; Middle Aged; Molecular Sequence Data; Peptide Fragments; Phenotype; Polymerase Chain Reaction; Predictive Value of Tests; Protein Precursors; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Sequence Analysis, DNA; White People | 2004 |
Insulin secretion and incretin hormones after oral glucose in non-obese subjects with impaired glucose tolerance.
Topics: Administration, Oral; Area Under Curve; Blood Glucose; Body Weight; C-Peptide; Case-Control Studies; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Insulin Secretion; Liver; Middle Aged; Peptide Fragments; Protein Precursors; Regression Analysis; Time Factors | 2004 |
In vitro induction of adult hepatic progenitor cells into insulin-producing cells.
Topics: Animals; Cell Differentiation; Gene Expression Profiling; Glucagon; Glucagon-Like Peptide 1; Glucose; Hepatocytes; Homeodomain Proteins; Insulin; Insulin Secretion; Liver; Male; Peptide Fragments; Potassium; Protein Precursors; Rats; Rats, Sprague-Dawley; Stem Cells; Time Factors; Tolbutamide; Trans-Activators; Transfection | 2004 |
GLP-1: target for a new class of antidiabetic agents?
Topics: Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Liraglutide; Peptide Fragments; Peptides; Protein Precursors; Venoms | 2004 |
Control of blood glucose by novel GLP-1 delivery using biodegradable triblock copolymer of PLGA-PEG-PLGA in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Excipients; Glucagon; Glucagon-Like Peptide 1; Hydrogels; Hypoglycemic Agents; Insulin; Lactic Acid; Male; Peptide Fragments; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Protein Precursors; Rats; Rats, Zucker; Solubility | 2004 |
Prior in vitro exposure to GLP-1 with or without GIP can influence the subsequent beta cell responsiveness.
Topics: Animals; Drug Combinations; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, G-Protein-Coupled | 2004 |
Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production.
Topics: Amino Acid Sequence; Animals; Cell Line; Circular Dichroism; Cyclic AMP; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Inhibitory Concentration 50; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Conformation; Protein Precursors; Rats; Receptors, Glucagon; Structure-Activity Relationship | 2004 |
Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1.
Topics: Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; DNA; Fasting; Female; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans; Lipase; Lipids; Lipolysis; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Palmitates; Peptide Fragments; Protein Precursors; Sex Characteristics; Signal Transduction; Sterol Esterase; Triglycerides | 2004 |
Effects of centrally injected GLP-1 in various experimental models of gastric mucosal damage.
Topics: Animals; Disease Models, Animal; Female; Gastric Acidity Determination; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Hydrogen-Ion Concentration; Injections; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Stomach Ulcer | 2004 |
Comparative effects of GLP-1 and GIP on cAMP production, insulin secretion, and in vivo antidiabetic actions following substitution of Ala8/Ala2 with 2-aminobutyric acid.
Topics: Adenylyl Cyclases; Alanine; Aminobutyrates; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Cyclic AMP; Diabetes Mellitus; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Obese; Models, Chemical; Peptide Fragments; Peptides; Protein Precursors; Protein Structure, Tertiary; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2004 |
Expression, purification, and C-terminal amidation of recombinant human glucagon-like peptide-1.
Topics: Animals; Arginine; Cathepsin A; Chromatography, Affinity; Chromatography, Ion Exchange; Cyanogen Bromide; Diabetes Mellitus, Type 2; Escherichia coli; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutathione Transferase; Humans; Insulin; Leucine; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins | 2004 |
Glucagon-like peptide 2 improves intestinal wound healing through induction of epithelial cell migration in vitro-evidence for a TGF--beta-mediated effect.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Epithelial Cells; Flow Cytometry; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Intestines; Peptide Fragments; Peptides; Protein Precursors; Rats; Transforming Growth Factor beta; Transforming Growth Factor beta1; Wound Healing | 2004 |
Effect of duodenal-jejunal exclusion in a non-obese animal model of type 2 diabetes: a new perspective for an old disease.
Topics: Anastomosis, Surgical; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Duodenum; Female; Follow-Up Studies; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Jejunum; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains | 2004 |
Novel "second-generation" approaches for the control of type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Peptide Fragments; Protease Inhibitors; Protein Precursors; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Receptors, Cytoplasmic and Nuclear; Transcription Factors | 2004 |
Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intraperitoneal; Injections, Intraventricular; Iodine Radioisotopes; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Oxyntomodulin; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Receptors, G-Protein-Coupled; Receptors, Glucagon; Venoms | 2004 |
In depth analysis of the N-terminal bioactive domain of gastric inhibitory polypeptide.
Topics: Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Hydrogen-Ion Concentration; Indicators and Reagents; Molecular Weight; Peptide Fragments; Plasmids; Protein Precursors; Radioligand Assay; Receptors, Gastrointestinal Hormone; Stimulation, Chemical | 2004 |
Recombinant glucagon-like peptide-1 increases myocardial glucose uptake and improves left ventricular performance in conscious dogs with pacing-induced dilated cardiomyopathy.
Topics: Animals; Blood Glucose; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Consciousness; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Energy Metabolism; Fatty Acids; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Clamp Technique; Heart Failure; Hemodynamics; Hyperinsulinism; Infusions, Intravenous; Insulin Resistance; Male; Myocardium; Oxygen Consumption; Peptide Fragments; Protein Precursors; Recombinant Proteins; Ventricular Dysfunction, Left | 2004 |
Ca(2+)-induced Ca(2+) release via inositol 1,4,5-trisphosphate receptors is amplified by protein kinase A and triggers exocytosis in pancreatic beta-cells.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Inositol 1,4,5-Trisphosphate Receptors; Islets of Langerhans; Mice; Mice, Obese; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Ryanodine | 2004 |
Cardiac metabolism as a target for the treatment of heart failure.
Topics: Acetanilides; Animals; Dogs; Energy Metabolism; Epoxy Compounds; Fatty Acids; Forecasting; Glucagon; Glucagon-Like Peptide 1; Glucose; Heart Failure; Humans; Insulin Resistance; Myocardium; Peptide Fragments; Piperazines; Protein Precursors; Ranolazine; Recombinant Proteins | 2004 |
A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis.
Topics: Albumins; Animals; Cells, Cultured; Cricetinae; Eating; Gastric Emptying; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Homeostasis; Humans; Kidney; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Peptide Fragments; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Receptors, Glucagon; Recombinant Proteins; Satiety Response | 2004 |
[Optimizing the managment of patients with diabetes mellitus: selected clinical trials from the 2004 Congress of the American Diabetes Association].
Topics: Anticholesteremic Agents; Atorvastatin; Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Complications; Diabetes Mellitus; Exenatide; Glucagon; Glucagon-Like Peptide 1; Heptanoic Acids; Humans; Islets of Langerhans Transplantation; Peptide Fragments; Peptides; Protein Precursors; Pyrroles; Venoms | 2004 |
[New diabetes therapy in clinical trial: will need adapted insulin supply be available soon? (interview by Dr. Judith Neumaier)].
Topics: Animals; Clinical Trials, Phase I as Topic; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Mice; Peptide Fragments; Protease Inhibitors; Protein Precursors | 2004 |
A gut feeling.
Topics: Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Peptide Fragments; Peptides; Protein Precursors; Venoms | 2004 |
Glucagon-like peptide-1 limits myocardial stunning following brief coronary occlusion and reperfusion in conscious canines.
Topics: Animals; Coronary Circulation; Disease Models, Animal; Dogs; Glucagon; Glucagon-Like Peptide 1; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardial Stunning; Peptide Fragments; Protein Precursors | 2005 |
Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7-36) analog.
Topics: Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Maleimides; Molecular Sequence Data; Peptide Fragments; Peptides; Protein Binding; Serum Albumin | 2004 |
Milrinone efficiently potentiates insulin secretion induced by orally but not intravenously administered glucose in C57BL6J mice.
Topics: Administration, Oral; Anesthesia; Animals; Blood Glucose; Drug Synergism; Female; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Glucose; Injections, Intravenous; Insulin; Insulin Secretion; Intubation, Gastrointestinal; Mice; Mice, Inbred C57BL; Milrinone; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Precursors; Stomach; Time Factors | 2004 |
Glutamine potently stimulates glucagon-like peptide-1 secretion from GLUTag cells.
Topics: Adenosine Triphosphate; Animals; Base Sequence; Calcium; Cell Line; DNA Primers; Electrophysiology; Glucagon; Glucagon-Like Peptide 1; Glutamine; Kinetics; Mice; Peptide Fragments; Peptide YY; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
Enhanced glucose-dependent glucagon-like peptide-1 and insulin secretion in Crohn patients with terminal ileum disease is unrelated to disease activity or ileal resection.
Topics: Adult; Aged; Blood Glucose; Case-Control Studies; Crohn Disease; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Homeostasis; Humans; Ileitis; Ileum; Insulin; Male; Middle Aged; Peptide Fragments; Protein Precursors | 2004 |
Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal.
Topics: Action Potentials; Afferent Pathways; Animals; Arousal; Choline; Digestive System; Eating; Exenatide; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Hypothalamic Hormones; Hypothalamus; Intracellular Signaling Peptides and Proteins; Melanins; Mice; Mice, Transgenic; Neurons; Neuropeptides; Orexin Receptors; Orexins; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Peptide Fragments; Peptides; Pituitary Hormones; Protein Precursors; Receptors, G-Protein-Coupled; Receptors, Glucagon; Receptors, Neuropeptide; Sodium Channel Blockers; Solitary Nucleus; Synaptic Transmission; Tetrodotoxin; Venoms; Viscera | 2004 |
Insulin feedback actions: complex effects involving isoforms of islet nitric oxide synthase.
Topics: Androstadienes; Animals; C-Peptide; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Feedback, Physiological; Female; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Mice; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Wortmannin | 2004 |
Weight loss through ileal transposition is accompanied by increased ileal hormone secretion and synthesis in rats.
Topics: Adaptation, Physiological; Animals; Bariatrics; Energy Intake; Feeding Behavior; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Ilium; Jejunum; Male; Peptide Fragments; Peptide YY; Protein Precursors; Rats; Rats, Long-Evans; Weight Loss | 2005 |
The role of central glucagon-like peptide-1 in mediating the effects of visceral illness: differential effects in rats and mice.
Topics: Animals; Anorexia; Avoidance Learning; Brain Diseases; Glucagon; Glucagon-Like Peptide 1; Lithium Chloride; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Neurons; Peptide Fragments; Proglucagon; Protein Precursors; Rats; Species Specificity; Taste | 2005 |
Reduced serum dipeptidyl peptidase-IV after metformin and pioglitazone treatments.
Topics: Aging; Animals; Blood Glucose; Cell Membrane; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glyburide; Hemoglobins; Hypoglycemic Agents; Insulin; Kidney; Liver; Male; Metformin; Peptide Fragments; Pioglitazone; PPAR gamma; Protein Precursors; Rats; Rats, Zucker; Thiazolidinediones | 2004 |
Different effects of whole milk and a fermented milk with the same fat and lactose content on gastric emptying and postprandial lipaemia, but not on glycaemic response and appetite.
Topics: Adult; Animals; Appetite; Blood Glucose; Cholecystokinin; Cholesterol; Cross-Over Studies; Cultured Milk Products; Dietary Fats; Fatty Acids, Nonesterified; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hydrogen-Ion Concentration; Insulin; Lactose; Lipid Metabolism; Lipids; Lipoproteins; Male; Milk; Peptide Fragments; Peptide YY; Postprandial Period; Protein Precursors; Triglycerides | 2004 |
Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats.
Topics: Animals; Appetite Regulation; Cecum; Colon; Diet; Eating; Energy Intake; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Inulin; Male; Organ Size; Peptide Fragments; Peptide Hormones; Proglucagon; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; Weight Gain | 2004 |
Pdx-1 is not sufficient for repression of proglucagon gene transcription in islet or enteroendocrine cells.
Topics: Animals; Cell Line; Endocrine Glands; Glucagon; Glucagon-Like Peptide 1; Homeodomain Proteins; Intestinal Mucosa; Intestines; Islets of Langerhans; Mice; Peptide Fragments; Proglucagon; Protein Precursors; Trans-Activators; Transcription, Genetic; Transduction, Genetic | 2005 |
Hindbrain contributions to anorexia.
Topics: Animals; Anorexia; Eating; Genes, fos; Glucagon; Glucagon-Like Peptide 1; Hindlimb; Injections, Intraventricular; Peptide Fragments; Protein Precursors; Rats; Signal Transduction; Vagus Nerve | 2004 |
Neural regulation of glucagon-like peptide-1 secretion in pigs.
Topics: Acetylcholine; Adrenergic Agents; Analysis of Variance; Animals; Atropine; Electric Stimulation; Enteric Nervous System; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Ileum; Isoproterenol; Neurotransmitter Agents; Norepinephrine; Organ Culture Techniques; Peptide Fragments; Phentolamine; Protein Precursors; Splanchnic Nerves; Swine; Vagus Nerve | 2004 |
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Family; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Male; Middle Aged; Peptide Fragments; Protein Precursors | 2004 |
Interplay of glucagon-like peptide-1 and transforming growth factor-beta signaling in insulin-positive differentiation of AR42J cells.
Topics: Animals; Cell Differentiation; Cell Line; DNA Primers; Equidae; Exenatide; Glucagon; Glucagon-Like Peptide 1; Insulin; Oligonucleotides, Antisense; Peptide Fragments; Peptides; Polymerase Chain Reaction; Protein Precursors; Signal Transduction; Transforming Growth Factor beta; Venoms | 2004 |
Orlistat augments postprandial increases in glucagon-like peptide-1 in obese type 2 diabetic patients: response to Damci et al.
Topics: Anti-Obesity Agents; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Lactones; Obesity; Orlistat; Peptide Fragments; Postprandial Period; Protein Precursors | 2004 |
Characterization of beta-cell function impairment in first-degree relatives of type 2 diabetic subjects: modeling analysis of 24-h triple-meal tests.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Diet; Energy Intake; Family; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Intolerance; Humans; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Linear Models; Male; Models, Biological; Multivariate Analysis; Peptide Fragments; Protein Precursors | 2005 |
Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon.
Topics: Animals; Cricetinae; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Models, Molecular; Mutagenesis; Peptide Fragments; Peptides; Pituitary Gland; Proglucagon; Proprotein Convertase 2; Protein Precursors; Protein Structure, Tertiary | 2005 |
Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide.
Topics: Animals; Appetite Regulation; Blood Glucose; Blotting, Western; Cannabinoids; Eating; Endocannabinoids; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Male; Oleic Acids; Peptide Fragments; Peptide Hormones; Piperidines; Protein Precursors; Pyrazoles; Rats; Rats, Wistar; Receptors, Drug; Rimonabant | 2004 |
S 23521 decreases food intake and body weight gain in diet-induced obese rats.
Topics: Adipose Tissue; Animals; Anti-Obesity Agents; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Obesity; Peptide Fragments; Random Allocation; Rats; Rats, Wistar; Time Factors; Weight Gain | 2004 |
Glucose stimulates the expression and activities of nitric oxide synthases in incubated rat islets: an effect counteracted by GLP-1 through the cyclic AMP/PKA pathway.
Topics: Animals; Bucladesine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cyclic N-Oxides; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; Free Radical Scavengers; Glucagon; Glucagon-Like Peptide 1; Glucose; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Isoquinolines; Male; Microdissection; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Protein Kinase Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Sulfonamides | 2005 |
Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo.
Topics: Animals; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Islets of Langerhans; Kinetics; Mice; Peptide Fragments; Protein Precursors; Receptors, Glucagon | 2004 |
Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas.
Topics: Animals; Area Under Curve; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Dose-Response Relationship, Drug; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Niacinamide; Pancreas; Peptide Fragments; Perfusion; Protein Precursors; Reference Values; Swine; Swine, Miniature | 2004 |
Transcriptional regulation of the IAPP gene in pancreatic beta-cells.
Topics: Amyloid; Animals; Anti-Ulcer Agents; Cells, Cultured; DNA-Binding Proteins; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 3-beta; Insulin; Interleukin-1; Islet Amyloid Polypeptide; Islets of Langerhans; Male; Mice; Mice, Transgenic; Nuclear Proteins; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2004 |
Glucagon-like peptide: the time is near.
Topics: Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Genetic Therapy; Glucagon; Glucagon-Like Peptide 1; Half-Life; Humans; Insulin; Insulin Secretion; Peptide Fragments; Protein Precursors | 2004 |
Activity-induced GLP-1 release in lean and obese subjects.
Topics: Adult; Analysis of Variance; Area Under Curve; Basal Metabolism; Blood Glucose; Enzyme-Linked Immunosorbent Assay; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Motor Activity; Obesity; Peptide Fragments; Protein Precursors; Thinness; Weight Loss | 2004 |
Overexpression of a dominant negative GIP receptor in transgenic mice results in disturbed postnatal pancreatic islet and beta-cell development.
Topics: Animals; Animals, Newborn; Area Under Curve; Blood Glucose; Body Weight; DNA; DNA, Complementary; Female; Genes, Dominant; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Immunohistochemistry; Insulin; Islets of Langerhans; Male; Mice; Mice, Transgenic; Pancreas; Peptide Fragments; Phenotype; Polymerase Chain Reaction; Proinsulin; Promoter Regions, Genetic; Protein Precursors; Receptors, Gastrointestinal Hormone; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2005 |
Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism.
Topics: Acetylcholine; Animals; Arteries; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Potassium; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 2005 |
Inhibition of dipeptidyl peptidase-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary adenylate cyclase-activating polypeptide, and gastrin-releasing peptid
Topics: Animals; Dipeptidyl Peptidase 4; Female; Gastric Inhibitory Polypeptide; Gastrin-Releasing Peptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Mice; Mice, Inbred C57BL; Nerve Growth Factors; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protease Inhibitors; Protein Precursors; Pyrroles; Valine | 2005 |
Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake.
Topics: Agouti-Related Protein; alpha-MSH; Amphetamines; Animals; Arcuate Nucleus of Hypothalamus; Binding, Competitive; Body Weight; Catecholamines; Cholecystokinin; Cocaine; Dopamine Uptake Inhibitors; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Hypothalamus; Immunohistochemistry; In Situ Hybridization; Inhibitory Concentration 50; Intercellular Signaling Peptides and Proteins; Leptin; Ligands; Male; Models, Biological; Neurons; Neuropeptide Y; Peptide Fragments; Peptide Hormones; Peptides; Plant Proteins; Pro-Opiomelanocortin; Protein Binding; Protein Precursors; Proteins; Rats; Rats, Sprague-Dawley; Rhombencephalon; RNA, Messenger; Thioglycolates; Time Factors; Toxins, Biological | 2005 |
Characterization and functional role of voltage gated cation conductances in the glucagon-like peptide-1 secreting GLUTag cell line.
Topics: Animals; Calcium; Cations, Monovalent; Cell Line; Electric Conductivity; Enteroendocrine Cells; Glucagon; Glucagon-Like Peptide 1; Ion Channel Gating; Ion Channels; Membrane Potentials; Mice; Peptide Fragments; Potassium; Protein Precursors; Sodium | 2005 |
Glucagon-like peptide 1 can directly protect the heart against ischemia/reperfusion injury.
Topics: Animals; Blood Pressure; Butadienes; Chromones; Disease Models, Animal; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Heart Rate; In Vitro Techniques; Insulin; Insulin Secretion; Male; MAP Kinase Signaling System; Morpholines; Myocardial Infarction; Myocardial Reperfusion Injury; Nitriles; Peptide Fragments; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Exenatide (exendin-4) improves insulin sensitivity and {beta}-cell mass in insulin-resistant obese fa/fa Zucker rats independent of glycemia and body weight.
Topics: Animals; Blood Glucose; Body Weight; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Insulin; Islets of Langerhans; Male; Obesity; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Zucker; Venoms | 2005 |
Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.
Topics: Animals; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Humans; Intestinal Mucosa; Mice; Molecular Sequence Data; Peptide Fragments; Polymerase Chain Reaction; Protein Precursors; Receptors, G-Protein-Coupled; RNA, Messenger | 2005 |
Synthesis, bioactivity and specificity of glucagon-like peptide-1 (7-37)/polymer conjugate to isolated rat islets.
Topics: Animals; Cell Culture Techniques; Cells, Cultured; Coated Materials, Biocompatible; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Materials Testing; Pancreas, Artificial; Peptide Fragments; Peptides; Polymers; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tissue Engineering | 2005 |
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Topics: Administration, Oral; Animals; Binding Sites; Biochemistry; Blood Glucose; Crystallography, X-Ray; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Models, Molecular; Peptide Fragments; Protein Conformation; Protein Precursors; Pyrazines; Rats; Sitagliptin Phosphate; Structure-Activity Relationship; Triazoles | 2005 |
Impaired circulating glucagon-like peptide-1 response to oral glucose in women with previous gestational diabetes.
Topics: Adult; Area Under Curve; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetes, Gestational; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Insulin; Peptide Fragments; Pregnancy; Protein Precursors; Secretory Rate | 2005 |
Engineered beta-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness.
Topics: Animals; Cell Line, Tumor; Clone Cells; Cricetinae; Cricetulus; Cyclic AMP; Dipeptidyl Peptidase 4; Genetic Engineering; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rabbits; Rats; Receptors, Glucagon; Transfection | 2005 |
Cholecystokinin, glucose dependent insulinotropic peptide and glucagon-like peptide 1 secretion in children with anorexia nervosa and simple obesity.
Topics: Adolescent; Anorexia Nervosa; Child; Cholecystokinin; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Obesity; Peptide Fragments; Protein Precursors; Radioimmunoassay | 2004 |
Dry matter intake is decreased more by abomasal infusion of unsaturated free fatty acids than by unsaturated triglycerides.
Topics: Abomasum; Animals; Blood Glucose; Blood Proteins; Cattle; Cholecystokinin; Eating; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Glycine max; Insulin; Lactation; Lipids; Medicago sativa; Milk; Peptide Fragments; Protein Precursors; Silage; Triglycerides; Zea mays | 2005 |
Effects of lipase inhibition on gastric emptying of, and on the glycaemic, insulin and cardiovascular responses to, a high-fat/carbohydrate meal in type 2 diabetes.
Topics: Aged; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Dietary Fats; Enzyme Inhibitors; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Heart Rate; Humans; Insulin; Insulin Secretion; Lactones; Lipase; Male; Middle Aged; Orlistat; Peptide Fragments; Protein Precursors | 2004 |
Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Androstadienes; Biological Transport; Cells, Cultured; Enzyme Activation; Exenatide; Female; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Indoles; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Cells; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Venoms; Wortmannin | 2005 |
beta-Cell Pdx1 expression is essential for the glucoregulatory, proliferative, and cytoprotective actions of glucagon-like peptide-1.
Topics: Animals; Blood Glucose; Cell Division; Cell Survival; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Homeodomain Proteins; Homeostasis; Islets of Langerhans; Mice; Mice, Knockout; Mice, Mutant Strains; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Trans-Activators; Venoms | 2005 |
GLP-1 reduces intestinal lymph flow, triglyceride absorption, and apolipoprotein production in rats.
Topics: Animals; Apolipoproteins A; Apolipoproteins B; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Lymph; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Time Factors; Triglycerides | 2005 |
Basal receptor activation by locally produced glucagon-like peptide-1 contributes to maintaining beta-cell function.
Topics: Animals; Enzyme-Linked Immunosorbent Assay; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 2005 |
The expression of GLP-1 receptor mRNA and protein allows the effect of GLP-1 on glucose metabolism in the human hypothalamus and brainstem.
Topics: Adult; Aged; Aged, 80 and over; Brain Stem; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Hypothalamus; Male; Middle Aged; Peptide Fragments; Protein Binding; Protein Precursors; Receptors, Glucagon; RNA, Messenger | 2005 |
A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk.
Topics: Chlorogenic Acid; Coffee; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Peptide Fragments; Protein Precursors | 2005 |
Genetically modified rice seeds accumulating GLP-1 analogue stimulate insulin secretion from a mouse pancreatic beta-cell line.
Topics: Animals; Base Sequence; Cell Line; Genetic Vectors; Globulins; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Oryza; Peptide Fragments; Protein Precursors; Recombinant Fusion Proteins; Seeds | 2005 |
Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats.
Topics: Animals; Appetite Depressants; Diet; Dose-Response Relationship, Drug; Eating; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Infusions, Intravenous; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 2005 |
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1.
Topics: Adenylyl Cyclase Inhibitors; alpha-Linolenic Acid; Animals; Bile Acids and Salts; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Enteroendocrine Cells; Genetic Vectors; Glucagon; Glucagon-Like Peptide 1; Imines; Mice; Peptide Fragments; Plasmids; Protein Precursors; Receptors, G-Protein-Coupled; RNA; RNA Interference; RNA, Messenger; Transfection | 2005 |
Free fatty acids increase PGC-1alpha expression in isolated rat islets.
Topics: Animals; Cells, Cultured; Colforsin; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Liver; Male; Mice; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; RNA, Small Interfering; Transcription Factors | 2005 |
Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Niacinamide; Oxidative Stress; Peptide Fragments; Peptides; Rats; Rats, Wistar; Streptozocin; Vasodilator Agents; Venoms | 2005 |
Distribution of proglucagon mRNA and GLP-1 in the brainstem of chicks.
Topics: Animals; Animals, Newborn; Brain Stem; Chickens; Eating; Fasting; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Male; Peptide Fragments; Proglucagon; Protein Precursors; RNA, Messenger | 2005 |
Glucagon-like peptide-1 mediates the therapeutic actions of DPP-IV inhibitors.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glycoproteins; Homeostasis; Humans; Models, Biological; Nausea; Peptide Fragments; Protein Precursors; Vomiting | 2005 |
The therapeutic actions of DPP-IV inhibition are not mediated by glucagon-like peptide-1.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glycoproteins; Homeostasis; Humans; Nausea; Peptide Fragments; Protein Precursors; Vomiting | 2005 |
Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycoproteins; Humans; Insulin; Insulin Secretion; Models, Biological; Nerve Growth Factors; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Time Factors | 2005 |
What mediates the benefits associated with dipeptidyl peptidase-IV inhibition?
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Animals; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Glycoproteins; Glycosylation; Humans; Metformin; Mice; Nerve Growth Factors; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors | 2005 |
Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function.
Topics: Animals; Autonomic Nervous System; Body Temperature; Cell Count; Cholera Toxin; Drinking; Eating; Functional Laterality; gamma-Aminobutyric Acid; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Heart Rate; Hypothalamus; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Medulla Oblongata; Microinjections; Motor Activity; Neural Pathways; Neuropeptides; Orexins; Peptide Fragments; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Time Factors; Tyrosine 3-Monooxygenase; Vagus Nerve | 2005 |
Nutrient-stimulated GLP-1 release in normal-weight men and women.
Topics: Administration, Oral; Adult; Body Mass Index; Eating; Female; Food; Galactans; Galactose; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Mannans; Middle Aged; Peptide Fragments; Plant Gums; Postprandial Period; Protein Precursors; Sex Factors | 2005 |
Proceedings from the GLP1 Meeting on the Occasion of the 80th Birthday of Prof. Dr. med. Dr. hc (em.) Werner Creutzfeldt.
Topics: Animals; Diabetes Mellitus, Type 2; Gastroenterology; Gastrointestinal Diseases; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; History, 20th Century; History, 21st Century; Humans; Liver Diseases; Pancreatic Diseases; Peptide Fragments; Peptides; Protein Precursors | 2005 |
The [pre-] history of the incretin concept.
Topics: Animals; Diabetes Mellitus; Gastric Inhibitory Polypeptide; Gastrin-Releasing Peptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; History, 20th Century; History, 21st Century; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Peptide Fragments; Peptides; Protein Precursors; Secretin | 2005 |
The discovery of glucagon-like peptide 1.
Topics: Animals; DNA, Complementary; Fishes; Glucagon; Glucagon-Like Peptide 1; History, 20th Century; Hormones; Peptide Fragments; Proglucagon; Protein Precursors; Recombinant Proteins | 2005 |
Contraction induced by glicentin on smooth muscle cells from the human colon is abolished by exendin (9-39).
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Animals; Cells, Cultured; Colon; Dose-Response Relationship, Drug; Female; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Male; Middle Aged; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Protein Precursors; Sequence Homology, Amino Acid | 2005 |
The recombinant rat glucagon-like peptide-1 receptor, expressed in an alpha-cell line, is coupled to adenylyl cyclase activation and intracellular calcium release.
Topics: Adenylyl Cyclases; Animals; Calcium; Cell Line; Cell Membrane; Cyclic AMP; Enzyme Activation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Intracellular Membranes; Islets of Langerhans; Membrane Potentials; Osmolar Concentration; Peptide Fragments; Phosphatidylinositols; Protein Precursors; Rats; Receptors, Glucagon; Recombinant Proteins | 2005 |
Characterization of an N-acylated glucagon-like peptide-1 derivative by electron capture dissociation.
Topics: Acylation; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Hypoglycemic Agents; Peptide Fragments; Protein Precursors; Spectroscopy, Fourier Transform Infrared | 2005 |
Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility.
Topics: Animals; Arginine; Blood Glucose; Food; Gastric Inhibitory Polypeptide; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Knockout; Pancreas; Peptide Fragments; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Precursors; Time Factors | 2005 |
The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits beta-cell apoptosis in vitro.
Topics: Animals; Apoptosis; Cyclic AMP; Cytokines; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Liraglutide; Nitric Oxide; Oxidoreductases; Peptide Fragments; Phosphatidylinositol 3-Kinases; Protein Precursors; Rats; Rats, Wistar; Signal Transduction | 2005 |
Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach.
Topics: Binding Sites; Binding, Competitive; Chromatography, High Pressure Liquid; Cloning, Molecular; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Hydrolysis; Kinetics; Models, Chemical; Peptide Fragments; Protein Binding; Protein Precursors; Protein Structure, Tertiary; Recombinant Proteins; Substrate Specificity; Temperature; Thermodynamics; Time Factors | 2005 |
[The role of incretins. Type 2 diabetes with new beginnings].
Topics: Diabetes Mellitus, Type 2; Disease Progression; Exenatide; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin Secretion; Peptide Fragments; Peptides; Protein Precursors; Venoms | 2005 |
Enhanced glucagon-like peptide-1 (GLP-1) response to oral glucose in glucose-intolerant HIV-infected patients on antiretroviral therapy.
Topics: Adult; Analysis of Variance; Antiretroviral Therapy, Highly Active; Antiviral Agents; Area Under Curve; Blood Glucose; Body Composition; C-Peptide; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Glucose Tolerance Test; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Male; Peptide Fragments; Protein Precursors | 2005 |
Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
Topics: Animals; Carrier Proteins; Cell Line; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Glyburide; Green Fluorescent Proteins; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Stimulation, Chemical | 2005 |
Pancreatic beta-cells expressing GLP-1 are resistant to the toxic effects of immunosuppressive drugs.
Topics: Animals; Antihypertensive Agents; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; Diazoxide; DNA Fragmentation; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Immunosuppressive Agents; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; Islets of Langerhans; Mice; Mitochondrial Proteins; Peptide Fragments; Protein Precursors; Proto-Oncogene Proteins c-bcl-2 | 2005 |
Coexistence of gastric- and intestinal-type endocrine cells in gastric and intestinal mixed intestinal metaplasia of the human stomach.
Topics: Aged; Chromogranin A; Chromogranins; Endocrine Glands; Female; Gastric Fundus; Gastric Inhibitory Polypeptide; Gastric Mucosa; Gastrins; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Immunohistochemistry; Intestines; Male; Metaplasia; Middle Aged; Peptide Fragments; Protein Precursors; Pyloric Antrum; Somatostatin; Stomach Neoplasms | 2005 |
Changes in glucagon-like peptide-1 (GLP-1) secretion after biliopancreatic diversion or vertical banded gastroplasty in obese subjects.
Topics: Adipocytes; Adult; Age Factors; Bariatrics; Biliopancreatic Diversion; Blood Glucose; Cholesterol; Cholesterol, LDL; Female; Follow-Up Studies; Gastroplasty; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Lipolysis; Male; Obesity, Morbid; Peptide Fragments; Protein Precursors; Triglycerides; Weight Loss | 2005 |
Synergistic effect of portal glucose and glucagon-like peptide-1 to lower systemic glucose and stimulate counter-regulatory hormones.
Topics: Animals; Blood Glucose; Dogs; Drug Synergism; Glucagon; Glucagon-Like Peptide 1; Glucose; Hydrocortisone; Infusions, Intravenous; Male; Models, Animal; Peptide Fragments; Portal Vein; Protein Precursors | 2005 |
Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes.
Topics: Administration, Oral; Blood Glucose; Cross-Over Studies; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Peptide Fragments; Protein Precursors | 2005 |
Chronic treatment with exendin(9-39)amide indicates a minor role for endogenous glucagon-like peptide-1 in metabolic abnormalities of obesity-related diabetes in ob/ob mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Insulin; Male; Mice; Mice, Obese; Obesity; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Time Factors | 2005 |
A cAMP and Ca2+ coincidence detector in support of Ca2+-induced Ca2+ release in mouse pancreatic beta cells.
Topics: Animals; Calcium; Calcium Channels; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Guanine Nucleotide Exchange Factors; Inositol 1,4,5-Trisphosphate Receptors; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Protein Precursors; Receptors, Cytoplasmic and Nuclear; Ryanodine Receptor Calcium Release Channel | 2005 |
Impact of inulin and oligofructose on gastrointestinal peptides.
Topics: Animals; Diabetes Mellitus, Experimental; Dietary Fiber; Eating; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Inulin; Male; Oligosaccharides; Peptide Fragments; Peptide Hormones; Peptide YY; Protein Precursors; Rats; Rats, Wistar | 2005 |
Glucagon like peptide-1 is protective against myocardial ischemia/reperfusion injury when given either as a preconditioning mimetic or at reperfusion in an isolated rat heart model.
Topics: Animals; Cardiotonic Agents; Glucagon; Glucagon-Like Peptide 1; Humans; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Male; Myocardial Reperfusion; Myocardial Reperfusion Injury; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Effects of metformin on glucagon-like peptide-1 levels in obese patients with and without Type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Obesity; Peptide Fragments; Protein Precursors | 2004 |
Effects of an olive oil-enriched diet on plasma GLP-1 concentration and intestinal content, plasma insulin concentration, and glucose tolerance in normal rats.
Topics: Animals; Blood Glucose; Body Weight; Diet; Dietary Fats, Unsaturated; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Intestinal Mucosa; Intestines; Male; Olive Oil; Peptide Fragments; Plant Oils; Protein Precursors; Rats; Rats, Wistar | 2005 |
Involvement of endogenous glucagon-like peptide-1(7-36) amide on glycaemia-lowering effect of oligofructose in streptozotocin-treated rats.
Topics: Actins; Animals; Blood Glucose; Colon; Diabetes Mellitus, Experimental; Eating; Fermentation; Food Deprivation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Tolerance Test; Insulin; Islets of Langerhans; Male; Oligosaccharides; Peptide Fragments; Proglucagon; Proprotein Convertase 1; Protein Precursors; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
In vitro transdifferentiation of hepatoma cells into functional pancreatic cells.
Topics: Active Transport, Cell Nucleus; Animals; Betacellulin; Carcinoma, Hepatocellular; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Etoposide; Gene Expression Regulation; Gene Expression Regulation, Developmental; Glucagon; Glucagon-Like Peptide 1; Hepatocytes; Homeodomain Proteins; Humans; Insulin; Intercellular Signaling Peptides and Proteins; Islets of Langerhans Transplantation; Liver; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Pancreas; Peptide Fragments; Phenotype; Plasmids; Polymerase Chain Reaction; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Time Factors; Trans-Activators; Transgenes | 2005 |
Participation of protein kinases in the stimulant action of GLP-1 on 2-deoxy-D-glucose uptake by normal rat skeletal muscle.
Topics: Animals; Biological Transport; Deoxyglucose; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Muscle, Skeletal; Organ Culture Techniques; Peptide Fragments; Protein Kinases; Protein Precursors; Rats; Rats, Wistar | 2005 |
Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1.
Topics: Animals; Body Weight; Dietary Fats; Dipeptidyl Peptidase 4; Eating; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Intestinal Mucosa; Liver; Male; Obesity; Oligosaccharides; Peptide Fragments; Peptide Hormones; Peptides; Proglucagon; Protein Precursors; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triglycerides | 2005 |
Erythromycin antagonizes the deceleration of gastric emptying by glucagon-like peptide 1 and unmasks its insulinotropic effect in healthy subjects.
Topics: Adult; Blood Glucose; C-Peptide; Cisapride; Domperidone; Eating; Erythromycin; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Infusions, Intravenous; Insulin; Male; Metoclopramide; Peptide Fragments; Placebos; Protein Precursors; Reference Values | 2005 |
Glucose dependence of the regulated secretory pathway in alphaTC1-6 cells.
Topics: Animals; Cell Division; Cell Line; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Kinetics; Peptide Fragments; Proglucagon; Protein Precursors; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2005 |
The Rap-B-Raf signalling pathway is activated by glucose and glucagon-like peptide-1 in human islet cells.
Topics: Cells, Cultured; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Products, vpr; Glucagon; Glucagon-Like Peptide 1; Glucose; GTP Phosphohydrolases; Humans; Immunohistochemistry; Islets of Langerhans; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Precursors; Proto-Oncogene Proteins B-raf; raf Kinases; Signal Transduction | 2005 |
The cytoplasmic domain close to the transmembrane region of the glucagon-like peptide-1 receptor contains sequence elements that regulate agonist-dependent internalisation.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Coated Pits, Cell-Membrane; Cytosol; Endocytosis; Gene Deletion; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Molecular Sequence Data; Mutagenesis; Peptide Fragments; Point Mutation; Protein Binding; Protein Precursors; Rats; Receptors, Glucagon; Signal Transduction | 2005 |
Cross-talk between bone morphogenetic protein and transforming growth factor-beta signaling is essential for exendin-4-induced insulin-positive differentiation of AR42J cells.
Topics: Animals; Benzothiazoles; Blotting, Western; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Cell Differentiation; Diamines; DNA Primers; DNA-Binding Proteins; Dose-Response Relationship, Drug; Exenatide; Glucagon; Glucagon-Like Peptide 1; Insulin; Islets of Langerhans; Ligands; Organic Chemicals; Peptide Fragments; Peptides; Phosphoproteins; Polymerase Chain Reaction; Protein Binding; Protein Isoforms; Protein Precursors; Quinolines; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Smad Proteins; Smad1 Protein; Smad5 Protein; Smad8 Protein; Trans-Activators; Transforming Growth Factor beta; Venoms | 2005 |
Active metabolite of GLP-1 mediates myocardial glucose uptake and improves left ventricular performance in conscious dogs with dilated cardiomyopathy.
Topics: Animals; Blood Pressure; Cardiomyopathy, Dilated; Consciousness; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Heart; Heart Ventricles; Male; Myocardium; Peptide Fragments; Peptides; Stroke Volume; Treatment Outcome; Ventricular Dysfunction, Left | 2005 |
Gastric bypass and nesidioblastosis--too much of a good thing for islets?
Topics: Adenosine Deaminase Inhibitors; Dipeptidyl Peptidase 4; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Glycoproteins; Humans; Hyperinsulinism; Hyperplasia; Hypoglycemia; Islets of Langerhans; Nesidioblastosis; Obesity; Peptide Fragments; Postoperative Complications; Protein Precursors; Signal Transduction | 2005 |
Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Genetic Vectors; Glucagon; Glucagon-Like Peptide 1; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Peptide Fragments; Plasmids; Protein Precursors | 2005 |
American Diabetes Association - 65th Scientific Sessions. DDP-IV inhibitors.
Topics: Adamantane; Animals; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Humans; Islets of Langerhans; Nitriles; Peptide Fragments; Protease Inhibitors; Protein Precursors; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Vildagliptin; Xanthines | 2005 |
Preservation of beta-cell function during immune-mediated, B7-1-dependent alpha-cell destruction.
Topics: Animals; B7-1 Antigen; Cell Death; Crosses, Genetic; Diabetes Mellitus, Type 1; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; Insulin; Islets of Langerhans; Islets of Langerhans Transplantation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments; Protein Precursors; Reverse Transcriptase Polymerase Chain Reaction; Statistics, Nonparametric; Tumor Necrosis Factor-alpha | 2005 |
Glucagon-like peptide-1 enhances production of insulin in insulin-producing cells derived from mouse embryonic stem cells.
Topics: Animals; C-Peptide; Cell Differentiation; Cell Line; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Immunohistochemistry; Insulin; Insulin Secretion; Mice; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Venoms | 2005 |
Glucagon-like peptide-1 stimulates human insulin promoter activity in part through cAMP-responsive elements that lie upstream and downstream of the transcription start site.
Topics: Animals; Cell Line, Tumor; Cyclic AMP; Electrophoretic Mobility Shift Assay; Gene Expression; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulinoma; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Response Elements; Transcription Initiation Site; Transfection | 2005 |
Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats.
Topics: Adipocytes; Animals; Biological Transport, Active; Deoxyglucose; Diabetes Mellitus, Experimental; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; In Vitro Techniques; Lipid Metabolism; Lipids; Lipolysis; Male; Peptide Fragments; Peptides; Protein Kinases; Protein Precursors; Rats; Rats, Wistar; Venoms | 2005 |
KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity.
Topics: Animals; Blood Glucose; Caco-2 Cells; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Kinetics; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Nicotinic Acids; Nitriles; Peptide Fragments; Peptide Hydrolases; Protein Precursors; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine | 2005 |
Delayed gastric emptying and intestinal hormones following pancreatoduodenectomy.
Topics: Acetaminophen; Aged; Female; Gastric Emptying; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Motilin; Neurotensin; Pancreatic Neoplasms; Pancreaticoduodenectomy; Peptide Fragments; Peptide YY; Prospective Studies; Protein Precursors | 2005 |
[Novel therapy in type 2 diabetes: to regulate glucose metabolism naturally].
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemic Agents; Infant, Newborn; Insulin Resistance; Lizards; Peptide Fragments; Peptides; Protein Precursors; Time Factors; Venoms | 2005 |
Glucagon-like peptide-1 reduces the pulsatile component of testosterone secretion in healthy males.
Topics: Administration, Oral; Adult; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Infusions, Intravenous; Insulin; Leptin; Luteinizing Hormone; Male; Peptide Fragments; Testosterone | 2005 |
Pancreatic epithelial cells can be converted into insulin-producing cells by GLP-1 in conjunction with virus-mediated gene transfer of pdx-1.
Topics: Adenoviridae; Animals; Biomarkers; Cell Differentiation; Cell Line, Transformed; Epithelial Cells; Gene Transfer Techniques; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeodomain Proteins; Insulin; Mice; Mice, Transgenic; Pancreas; Peptide Fragments; Protein Precursors; Trans-Activators | 2005 |
Hormonal regulation of leptin receptor expression in primary cultures of porcine hepatocytes.
Topics: Animals; Cyclic AMP; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hepatocytes; Insulin; Liver Glycogen; Male; Peptide Fragments; Peptide Hormones; Protein Isoforms; Receptors, Cell Surface; Receptors, Leptin; Reverse Transcriptase Polymerase Chain Reaction; RNA; Triiodothyronine; Up-Regulation | 2005 |
Human duodenal enteroendocrine cells: source of both incretin peptides, GLP-1 and GIP.
Topics: Adult; Aged; Aged, 80 and over; Area Under Curve; Biopsy; Diabetes Mellitus, Type 2; Duodenum; Enteroendocrine Cells; Enzyme-Linked Immunosorbent Assay; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Humans; Immunohistochemistry; Insulin; Insulin Resistance; Male; Middle Aged; Peptide Fragments; Reverse Transcriptase Polymerase Chain Reaction | 2006 |
The effect of production level on feed intake, milk yield, and endocrine responses to two fatty acid supplements in lactating cows.
Topics: 3-Hydroxybutyric Acid; Animals; Behavior, Animal; Blood Glucose; Cattle; Cholecystokinin; Eating; Energy Metabolism; Fats; Fatty Acids; Fatty Acids, Nonesterified; Fatty Acids, Unsaturated; Female; Glucagon; Glucagon-Like Peptide 1; Growth Hormone; Hormones; Insulin; Lactation; Lactose; Mastication; Milk; Milk Proteins | 2005 |
Increased glucose tolerance and reduced adiposity in the absence of fasting hypoglycemia in mice with liver-specific Gs alpha deficiency.
Topics: Adiposity; Animals; Eating; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; GTP-Binding Protein alpha Subunits, Gs; Hypoglycemia; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Lipid Metabolism; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Oxygen Consumption; Signal Transduction | 2005 |
A model of controlled acute hyperglycemia in rats: Effects of insulin and glucagon-like peptide-1 analog.
Topics: Acute Disease; Anesthesia; Animals; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucose; Growth Hormone; Hyperglycemia; Insulin; Male; Rats; Rats, Sprague-Dawley | 2006 |
New ways in which GLP-1 can regulate glucose homeostasis.
Topics: Animals; Brain; Central Nervous System; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Humans; Insulin; Models, Biological; Peptide Fragments; Proglucagon | 2005 |
Plasma concentrations of glucagon-like peptide-2 in adult patients with treated and untreated coeliac disease.
Topics: Adult; Celiac Disease; Female; Follow-Up Studies; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Glutens; Humans; Male; Middle Aged; Radioimmunoassay; Treatment Outcome | 2006 |
Pituitary adenylate cyclase-activating peptide (PACAP): assessment of dipeptidyl peptidase IV degradation, insulin-releasing activity and antidiabetic potential.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Insulin Secretion; Mice; Mice, Obese; Molecular Sequence Data; Pituitary Adenylate Cyclase-Activating Polypeptide; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2006 |
Oscillations of cyclic AMP in hormone-stimulated insulin-secreting beta-cells.
Topics: Animals; Calcium; Calcium Signaling; Cell Line; Cell Nucleus; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Protein Subunits; Protein Transport; Rats | 2006 |
Direct effects of glucagon-like peptide-1 on myocardial contractility and glucose uptake in normal and postischemic isolated rat hearts.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Transporter Type 1; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardium; Nitric Oxide; Peptide Fragments; Protein Transport; Rats; Rats, Wistar; Ventricular Function, Left | 2006 |
Effects of intravenous glucagon-like peptide-1 on gastric emptying and intragastric distribution in healthy subjects: relationships with postprandial glycemic and insulinemic responses.
Topics: Adult; Appetite; Blood Glucose; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastric Mucosa; Glucagon; Glucagon-Like Peptide 1; Humans; Hunger; Injections, Intravenous; Insulin; Male; Postprandial Period; Satiety Response; Stomach; Treatment Outcome | 2006 |
Transcription factor FoxO1 mediates glucagon-like peptide-1 effects on pancreatic beta-cell mass.
Topics: Animals; Cell Division; Cell Line; Cell Survival; Forkhead Box Protein O1; Forkhead Transcription Factors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Green Fluorescent Proteins; Insulin; Islets of Langerhans; Mice; Mice, Transgenic; Peptide Fragments | 2006 |
Exogenously imposed postprandial-like rises in systemic glucose and GLP-1 do not produce an incretin effect, suggesting an indirect mechanism of GLP-1 action.
Topics: Animals; Area Under Curve; C-Reactive Protein; Dogs; Eating; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin-Secreting Cells; Male; Postprandial Period; Random Allocation | 2006 |
Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice.
Topics: Animals; Bioreactors; Blood Glucose; Cell Line; Chlorocebus aethiops; COS Cells; Cyclic AMP; Diabetes Mellitus, Type 2; Genetic Therapy; Glucagon; Glucagon-Like Peptide 1; Half-Life; Immunoglobulin Fc Fragments; Immunoglobulin G; Insulin; Mice; Mice, Obese; Models, Animal; Recombinant Fusion Proteins; Transfection | 2007 |
Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Insulin; Male; Middle Aged; Time Factors | 2007 |
Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1.
Topics: Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Glucagon; Glucagon-Like Peptide 1; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Male; Potassium Channels; Rats; Rats, Wistar; Somatostatin; Tolbutamide | 2007 |
Awareness of pathophysiological concepts of type 2 diabetes: a survey in 847 physicians.
Topics: Clinical Competence; Diabetes Mellitus, Type 2; Family Practice; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Humans; Insulin Resistance; Insulin-Secreting Cells; Liver; Online Systems; Primary Health Care; Surveys and Questionnaires | 2007 |
Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects.
Topics: Administration, Oral; Adult; Cohort Studies; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Infusions, Intravenous; Insulin; Male; Middle Aged; Time Factors | 2007 |
Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s).
Topics: Animals; Arrestins; beta-Adrenergic Receptor Kinases; beta-Arrestins; Chlorocebus aethiops; COS Cells; Cyclic AMP; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 5; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; GTP-Binding Protein alpha Subunits, Gs; Humans; Luminescent Measurements; Oxyntomodulin; Protein Serine-Threonine Kinases; Receptors, Glucagon; Signal Transduction | 2007 |
Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
Topics: Adult; Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glutaminase; Homeostasis; Humans; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; Male; Middle Aged; Models, Biological | 2007 |
Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes.
Topics: Adolescent; ATP-Binding Cassette Transporters; Blood Glucose; C-Peptide; Child; Cohort Studies; Diabetes Mellitus, Type 1; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glycated Hemoglobin; Humans; Immunohistochemistry; Insulin-Secreting Cells; Male; Postprandial Period; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2007 |
Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes.
Topics: Adolescent; ATP-Binding Cassette Transporters; Blotting, Western; C-Peptide; Child; Diabetes Mellitus, Type 1; Eating; Female; Gastric Inhibitory Polypeptide; Genotype; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperglycemia; Hypoglycemic Agents; Ileum; Immunohistochemistry; Insulin; Islets of Langerhans; Male; Polymorphism, Restriction Fragment Length; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors | 2007 |
[Glucagon-like peptide-1 (GLP-1), new target for the treatment of type 2 diabetes].
Topics: Adamantane; Animals; Appetite; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Liraglutide; Nitriles; Peptides; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Venoms; Vildagliptin | 2007 |
The effects of duodenal-jejunal exclusion on hormonal regulation of glucose metabolism in Goto-Kakizaki rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Homeostasis; Insulin; Leptin; Male; Rats; Rats, Inbred Strains | 2007 |
Editorial: The role of glucagon in postprandial hyperglycemia--the jury's still out.
Topics: Blood Glucose; C-Peptide; Child; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glycated Hemoglobin; Humans; Hyperglycemia; Insulin; Postprandial Period; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Sulfonylurea Compounds | 2007 |
Intraportal GLP-1 infusion increases nonhepatic glucose utilization without changing pancreatic hormone levels.
Topics: Animals; Blood Glucose; Dogs; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Clamp Technique; Infusions, Intravenous; Insulin; Liver; Male; Pancreatic Hormones; Portal Vein; Regional Blood Flow | 2007 |
The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Incretins; Insulin; Male; Middle Aged; Pancreatitis, Chronic | 2007 |
GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet.
Topics: Adipokines; Adipose Tissue; Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Corticosterone; Dietary Fats; Eating; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Incretins; Insulin; Insulin Resistance; Lipids; Liver; Male; Mice; Motor Activity; Muscle, Skeletal; Obesity; Pancreas; Receptors, Gastrointestinal Hormone | 2007 |
Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal.
Topics: Adult; Aged; Blood Glucose; Body Mass Index; C-Peptide; Eating; Female; Food; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemia; Incretins; Insulin; Insulin Resistance; Male; Middle Aged; Obesity; Obesity, Morbid; Postoperative Complications | 2007 |
Upregulation of the brainstem preproglucagon system in the obese Zucker rat.
Topics: Animals; Appetite Regulation; Brain Stem; Caloric Restriction; Circadian Rhythm; Fluorescent Antibody Technique; Food Deprivation; Food, Formulated; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; In Situ Hybridization; Leptin; Male; Obesity; Proglucagon; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptors, Glucagon; Receptors, Leptin; RNA, Messenger; Solitary Nucleus; Up-Regulation | 2008 |
Intraportally delivered GLP-1, in the presence of hyperglycemia induced via peripheral glucose infusion, does not change whole body glucose utilization.
Topics: Animals; Blood Glucose; Dogs; Enzyme-Linked Immunosorbent Assay; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Hyperglycemia; Infusions, Intravenous; Insulin; Liver Circulation; Male | 2008 |
Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Glucose Tolerance Test; Humans; Incretins; Male; Middle Aged; Triglycerides | 2008 |
Influence of BMI and gender on postprandial hormone responses.
Topics: Adult; Analysis of Variance; Blood Glucose; Body Composition; Body Mass Index; Female; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Leptin; Male; Middle Aged; Obesity; Postprandial Period; Sex Characteristics | 2007 |
[The change of glucagon-like peptide-1 and its effect on blood glucose metabolism after major surgery].
Topics: Adult; Animals; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Hepatectomy; Humans; Insulin; Male; Middle Aged; Rats; Rats, Sprague-Dawley; Surgical Procedures, Operative | 2008 |
Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with type 2 diabetes.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Diet, Reducing; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Male; Middle Aged; Obesity; Weight Loss | 2008 |
Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2008 |
Exenatide can reduce glucose independent of islet hormones or gastric emptying.
Topics: Animals; Blood Glucose; Dogs; Exenatide; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Islets of Langerhans; Peptide Fragments; Peptides; Postprandial Period; Venoms | 2008 |
Chronic administration of alogliptin, a novel, potent, and highly selective dipeptidyl peptidase-4 inhibitor, improves glycemic control and beta-cell function in obese diabetic ob/ob mice.
Topics: Animals; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Insulin; Male; Mice; Mice, Obese; Piperidines; Triglycerides; Uracil | 2008 |
Incretin and islet hormonal responses to fat and protein ingestion in healthy men.
Topics: Adult; Blood Glucose; Body Water; Diet; Dietary Fats; Dietary Proteins; Dipeptidyl Peptidase 4; Fatty Acids, Nonesterified; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Islets of Langerhans; Male; Pancreatic Hormones; Triglycerides | 2008 |
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas.
Topics: Animals; Antibodies; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Pancreas; Perfusion; Rats; Rats, Wistar; Receptors, Somatostatin; Somatostatin | 2008 |
Inhibition of dipeptidyl peptidase-4 by vildagliptin during glucagon-like Peptide 1 infusion increases liver glucose uptake in the conscious dog.
Topics: Adamantane; Animals; Consciousness; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dogs; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Liver; Nitriles; Pyrrolidines; Vildagliptin | 2009 |
Effect of glucagon-like peptide-1 on beta- and alpha-cell function in isolated islet and whole pancreas transplant recipients.
Topics: Adult; Arginine; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Insulin; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Male; Middle Aged; Pancreas Transplantation; Proinsulin | 2009 |
What is known, new and controversial about GLP-1? Minutes of the 1st European GLP-1 Club Meeting, Marseille, 28-29 May 2008.
Topics: Animals; Cell Differentiation; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; France; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; L Cells; Mice | 2008 |
Four weeks of near-normalization of blood glucose has no effect on postprandial GLP-1 and GIP secretion, but augments pancreatic B-cell responsiveness to a meal in patients with Type 2 diabetes.
Topics: Area Under Curve; Blood Glucose; Diabetes Mellitus, Type 2; Eating; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Middle Aged; Postprandial Period | 2008 |
The dipeptidyl peptidase IV inhibitor NVP-DPP728 reduces plasma glucagon concentration in cats.
Topics: Animals; Cats; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Male; Nitriles; Pyrrolidines | 2010 |
Hyperglycemia acutely lowers the postprandial excursions of glucagon-like Peptide-1 and gastric inhibitory polypeptide in humans.
Topics: Adult; Body Mass Index; C-Peptide; Cholesterol, HDL; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Hyperglycemia; Kidney Function Tests; Liver Function Tests; Male; Postprandial Period; Reference Values; Young Adult | 2009 |
Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Inositol; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Time Factors | 2009 |
Peripheral satiety signals: view from the Chair.
Topics: Animals; Appetite Regulation; Cholecystokinin; Feeding Behavior; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Medulla Oblongata; Peptide Fragments; Peptide Hormones; Peptide YY; Rats; Satiety Response; Subfornical Organ; Vagus Nerve | 2009 |
Combining a dipeptidyl peptidase-4 inhibitor, alogliptin, with pioglitazone improves glycaemic control, lipid profiles and beta-cell function in db/db mice.
Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Cell Degranulation; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Eating; Glucagon; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Lipids; Male; Mice; Pioglitazone; Piperidines; Thiazolidinediones; Uracil | 2009 |
Incretins in the ICU: is insulin on its way out?
Topics: Female; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Hyperglycemia; Hypoglycemia; Incretins; Insulin; Intensive Care Units; Male; Outcome Assessment, Health Care | 2009 |
Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage.
Topics: Animals; Arginine; Benzoates; Body Weight; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Male; Obesity; Organ Culture Techniques; Pancreas; Peptide Fragments; Rats; Rats, Sprague-Dawley; Tolbutamide | 2009 |
Clozapine and quetiapine acutely reduce glucagon-like peptide-1 production and increase glucagon release in obese rats: implications for glucose metabolism and food choice behaviour.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Body Composition; Body Weight; Clozapine; Dibenzothiazepines; Dietary Fats; Disease Models, Animal; Eating; Exenatide; Food Preferences; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Hypoglycemic Agents; Insulin Resistance; Male; Obesity; Peptides; Pyrazines; Quetiapine Fumarate; Rats; Rats, Sprague-Dawley; Sitagliptin Phosphate; Triazoles; Venoms | 2009 |
Mechanism of action of inhibitors of dipeptidyl-peptidase-4 (DPP-4).
Topics: Adamantane; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Insulin; Nitriles; Pyrazines; Pyrrolidines; Sitagliptin Phosphate; Triazoles; Vildagliptin | 2009 |
Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Glipizide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Ki-67 Antigen; Lipids; Liver; Male; Mice; Mice, Inbred ICR; Organ Size; Pyrazines; Sitagliptin Phosphate; Triazoles; Triglycerides | 2009 |
Age dependence of glucose tolerance in adult KK-Ay mice, a model of non-insulin dependent diabetes mellitus.
Topics: Age Factors; Amyloid; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Islet Amyloid Polypeptide; Leptin; Male; Mice; Mice, Inbred ICR | 2009 |
Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report.
Topics: Area Under Curve; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Enteral Nutrition; Fatty Acids, Nonesterified; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Male; Middle Aged; Obesity, Morbid; Peptide YY; Postoperative Period; Postprandial Period | 2010 |
Does glucagon-like peptide-1 receptor agonist therapy add value in the treatment of type 2 diabetes? Focus on exenatide.
Topics: Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Incretins; Insulin-Secreting Cells; Peptides; Phenotype; Receptors, Glucagon; Venoms | 2009 |
Reversible hyperinsulinemic hypoglycemia after gastric bypass: a consequence of altered nutrient delivery.
Topics: Adult; Blood Glucose; Body Mass Index; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperinsulinism; Hypoglycemia; Insulin; Nutritional Status; Obesity, Morbid; Postoperative Complications | 2010 |
Long-term dietary restriction influences plasma ghrelin and GOAT mRNA level in rats.
Topics: Acyltransferases; Age Factors; Amyloid; Animals; Body Weight; Diet; Enzyme-Linked Immunosorbent Assay; Gastrointestinal Tract; Gene Expression Regulation; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Insulin; Islet Amyloid Polypeptide; Leptin; Rats; Rats, Wistar; RNA, Messenger; Statistics, Nonparametric; Time Factors | 2010 |
The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action.
Topics: Adult; Analysis of Variance; Area Under Curve; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Time Factors; Treatment Outcome | 2010 |
A model of GLP-1 action on insulin secretion in nondiabetic subjects.
Topics: Adult; Blood Glucose; C-Peptide; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Models, Biological | 2010 |
Effect of glucagon-like peptide-1 on alpha- and beta-cell function in C-peptide-negative type 1 diabetic patients.
Topics: Arginine; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Hyperglycemia; Insulin-Secreting Cells; Serum Albumin | 2010 |
[Effect of glucagon-like peptide-1 on hypoxia-reoxygenation induced injury in neonatal rat cardiomyocytes].
Topics: Animals; Animals, Newborn; Apoptosis; Caspase 3; Cell Hypoxia; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Myocardial Reperfusion Injury; Myocytes, Cardiac; Rats; Rats, Wistar | 2010 |
Reduced glucose tolerance and insulin resistance induced by steroid treatment, relative physical inactivity, and high-calorie diet impairs the incretin effect in healthy subjects.
Topics: Adult; Area Under Curve; Blood Glucose; Body Weight; C-Peptide; Diet; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Resistance; Male; Motor Activity; Prednisolone | 2010 |
The effect on glucagon, glucagon-like peptide-1, total and acyl-ghrelin of dietary fats ingested with and without potato.
Topics: Adolescent; Adult; Analysis of Variance; Area Under Curve; Body Mass Index; Dietary Carbohydrates; Dietary Fats; Eating; Female; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Radioimmunoassay; Solanum tuberosum; Time Factors | 2010 |
Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans.
Topics: Aged; Analysis of Variance; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Male; Middle Aged; Postprandial Period | 2010 |
Effects of physiological hyperglycemia on duodenal motility and flow events, glucose absorption, and incretin secretion in healthy humans.
Topics: Adult; Analysis of Variance; Area Under Curve; Blood Glucose; Duodenum; Electric Impedance; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hyperglycemia; Incretins; Insulin; Male; Manometry; Single-Blind Method | 2010 |
GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
Topics: Animals; Calcium Channels, L-Type; Calcium Channels, N-Type; Carrier Proteins; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epinephrine; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Guanine Nucleotide Exchange Factors; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred C57BL | 2010 |
Prolonged survival and improved glycemia in BioBreeding diabetic rats after early sustained exposure to glucagon-like peptide 1.
Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Implants, Experimental; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pancreas; Rats; Rats, Inbred BB; Rats, Wistar; Transduction, Genetic | 2010 |
Pancreas-specific Gsalpha deficiency has divergent effects on pancreatic alpha- and beta-cell proliferation.
Topics: Analysis of Variance; Animals; Body Composition; Cell Line; Cell Proliferation; Cells, Cultured; Cyclic AMP; Eating; Enzyme-Linked Immunosorbent Assay; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose Tolerance Test; GTP-Binding Protein alpha Subunits, Gs; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Mice; Mice, Transgenic; Pancreas; Radioimmunoassay; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2010 |
Taking aim at islet hormones with GLP-1: is insulin or glucagon the better target?
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin | 2010 |
GLP-1 (9-36) amide metabolite suppression of glucose production in isolated mouse hepatocytes.
Topics: Amides; Animals; Cell Separation; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Hepatocytes; Mice; Mice, Inbred C57BL; Phosphoenolpyruvate Carboxykinase (GTP); Receptors, Glucagon; RNA, Messenger | 2010 |
Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Peptide Fragments; Receptors, Glucagon; Signal Transduction | 2010 |
Weight loss and incretin responsiveness improve glucose control independently after gastric bypass surgery.
Topics: Adiponectin; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Secretion; Leptin; Middle Aged; Obesity, Morbid; Postoperative Period; Stomach; Weight Loss | 2010 |
The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets.
Topics: Alanine; Animals; Arginine; Cadherins; Cell Communication; Cell Proliferation; Cell Survival; Cells, Cultured; Connexin 43; Connexins; Gap Junction delta-2 Protein; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Somatostatin; Somatostatin-Secreting Cells | 2010 |
Role of GLP-1 induced glucagon suppression in type 2 diabetes mellitus.
Topics: Blood Glucose; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Male | 2010 |
Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin secretion in rodents and from human islets.
Topics: Animals; Cyclic AMP; Gastric Inhibitory Polypeptide; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Luciferases; Male; Parathyroid Hormone; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Vasoactive Intestinal Peptide | 2010 |
Distinguishing among incretin-based therapies. Glucose-lowering effects of incretin-based therapies.
Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Resistance; Liraglutide; Male; Metformin; Middle Aged; Peptides; Pyrazines; Receptors, Glucagon; Sitagliptin Phosphate; Triazoles; Venoms | 2010 |
Distinguishing among incretin-based therapies. Safety, tolerability, and nonglycemic effects of incretin-based therapies.
Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Incretins; Insulin; Liraglutide; Male; Metformin; Middle Aged; Peptides; Pyrazines; Receptors, Glucagon; Risk; Sitagliptin Phosphate; Triazoles; Venoms; Weight Loss | 2010 |
Distinguishing among incretin-based therapies. Patient education and self-management.
Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Resistance; Liraglutide; Male; Metformin; Middle Aged; Patient Education as Topic; Peptides; Pyrazines; Receptors, Glucagon; Self Care; Sitagliptin Phosphate; Triazoles; Venoms | 2010 |
Distinguishing among incretin-based therapies. Pathophysiology of type 2 diabetes mellitus: potential role of incretin-based therapies.
Topics: Adamantane; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptides; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Insulin-Secreting Cells; Liraglutide; Male; Metformin; Middle Aged; Peptides; Pyrazines; Severity of Illness Index; Sitagliptin Phosphate; Time Factors; Triazoles; Venoms | 2010 |
Endogenous GLP-1 regulates postprandial glycemia in humans: relative contributions of insulin, glucagon, and gastric emptying.
Topics: Adult; Blood Glucose; Body Mass Index; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Linear Models; Male; Peptide Fragments; Postprandial Period; Radioimmunoassay | 2011 |
Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects.
Topics: Adult; Area Under Curve; Blood Glucose; C-Peptide; Diet; Energy Intake; Fasting; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Motor Activity; Postprandial Period; Prednisolone; Young Adult | 2011 |
GPR119 regulates murine glucose homeostasis through incretin receptor-dependent and independent mechanisms.
Topics: Animals; Blood Glucose; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxadiazoles; Pyrimidines; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone | 2011 |
GLP-1: what is known, new and controversial in 2010?
Topics: Animals; Endocrine System; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Molecular Targeted Therapy; Peptides | 2010 |
Pre-treatment with a DPP-4 inhibitor is infarct sparing in hearts from obese, pre-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Cardiotonic Agents; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Resistance; Male; Myocardial Reperfusion Injury; Myocytes, Cardiac; Obesity; Pancreas; Phosphotransferases; Prediabetic State; Rats; Rats, Wistar | 2011 |
Involvement of endogenous glucagon-like peptide-1 in regulation of gastric motility and pancreatic endocrine secretion.
Topics: Adult; Blood Glucose; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hunger; Insulin; Male; Nausea; Pancreas; Peptide Fragments; Peptide YY; Postprandial Period; Satiation | 2011 |
Sustained glucagon-like peptide 1 expression from encapsulated transduced cells to treat obese diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Muscle, Smooth, Vascular; Obesity; Rats; Rats, Wistar; Receptors, Leptin; Transduction, Genetic | 2011 |
Diet and gastrointestinal bypass-induced weight loss: the roles of ghrelin and peptide YY.
Topics: Analysis of Variance; Animals; Colon; Diet, Fat-Restricted; Diet, Reducing; Enzyme-Linked Immunosorbent Assay; Gastric Bypass; Gastric Mucosa; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Leptin; Male; Mice; Obesity; Peptide YY; Radioimmunoassay; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Weight Loss | 2011 |
Charge inversion at position 68 of the glucagon and glucagon-like peptide-1 receptors supports selectivity in hormone action.
Topics: Amino Acid Sequence; Cell Line; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Molecular Sequence Data; Mutation; Protein Binding; Receptors, Glucagon | 2011 |
Sitagliptin lowers glucagon and improves glucose tolerance in prediabetic obese SHROB rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles | 2011 |
The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin-Secreting Cells; Male; Middle Aged; Peptides | 2011 |
Glucose- and hormone-induced cAMP oscillations in α- and β-cells within intact pancreatic islets.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Calcium; Cyclic AMP; Enzyme Inhibitors; Epinephrine; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Oximes | 2011 |
Divergent effects of GLP-1 analogs exendin-4 and exendin-9 on the expression of myosin heavy chain isoforms in C2C12 myotubes.
Topics: Animals; Blotting, Western; Calcineurin; Calcium; Cell Differentiation; Cell Line; Cytosol; Exenatide; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Hypoglycemic Agents; Insulin; Insulin Resistance; Mice; Muscle Fibers, Skeletal; Myoblasts; Myosin Heavy Chains; Peptide Fragments; Peptides; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Isoforms; Receptors, Glucagon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trans-Activators; Transcription Factors; Venoms | 2011 |
GLP-1 analogs containing disulfide bond exhibited prolonged half-life in vivo than GLP-1.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Disulfides; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycated Hemoglobin; Half-Life; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Male; Molecular Sequence Data; Peptides; Protein Binding; Protein Stability; Rats; Venoms | 2011 |
A diabetes drug, sitagliptin, also has a potential to prevent diabetes.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Insulin Secretion; Pyrazines; Rats; Sitagliptin Phosphate; Triazoles | 2011 |
Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog.
Topics: Acetaminophen; Animals; Blood Glucose; Dogs; Enteroendocrine Cells; Female; Food; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Homeostasis; Insulin; Kinetics; Male; Peptide Fragments; Receptors, Glucagon | 2011 |
Genetic tracing of Nav1.8-expressing vagal afferents in the mouse.
Topics: Afferent Pathways; Animals; Fluorescent Dyes; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myenteric Plexus; NAV1.8 Voltage-Gated Sodium Channel; Neurons, Afferent; Sodium Channels; Vagus Nerve | 2011 |
Olanzapine effects on body composition, food preference, glucose metabolism and insulin sensitivity in the rat.
Topics: Animals; Antipsychotic Agents; Benzodiazepines; Body Composition; Body Weight; Diet, High-Fat; Food Preferences; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Liver; Male; Obesity; Olanzapine; Rats; Schizophrenia; Weight Gain | 2011 |
Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dietary Fats; Dipeptidyl-Peptidase IV Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Hypertrophy; In Vitro Techniques; Male; Mice; Mice, Knockout; Obesity; Receptors, Glucagon; Streptozocin | 2011 |
Intragastric infusion of pea-protein hydrolysate reduces test-meal size in rats more than pea protein.
Topics: Animals; Area Under Curve; Drug Administration Routes; Eating; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Insulin; Male; Parasympathectomy; Pisum sativum; Protein Hydrolysates; Proteins; Rats; Rats, Sprague-Dawley; Time Factors; Vagus Nerve | 2011 |
Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?
Topics: Animals; Cell Line; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Models, Animal; Paracrine Communication; Proglucagon; Proprotein Convertase 1; Rats; Rats, Wistar | 2011 |
Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1.
Topics: Adolescent; Adult; Age of Onset; Aged; Case-Control Studies; Child; Child, Preschool; Czechoslovakia; Denmark; Diabetes Mellitus, Type 2; Europe; Female; Genetic Association Studies; Glucagon; Glucagon-Like Peptide 1; Homozygote; Humans; Infant; Insulin; Insulin Resistance; Insulin Secretion; Male; Middle Aged; Obesity; Polymorphism, Single Nucleotide | 2011 |
Long in the shade, glucagon re-occupies centre court.
Topics: Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia | 2011 |
Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans.
Topics: Adult; Blood Glucose; Female; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Pancreas; Postprandial Period | 2011 |
Glucagon and a glucagon-GLP-1 dual-agonist increases cardiac performance with different metabolic effects in insulin-resistant hearts.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Cardiotonic Agents; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycolysis; Heart; Heart Rate; HEK293 Cells; Humans; Insulin Resistance; Male; Oxidation-Reduction; Palmitates; Peptides; Rats | 2012 |
Engineering an L-cell line that expresses insulin under the control of the glucagon-like peptide-1 promoter for diabetes treatment.
Topics: Animals; Cell Line, Tumor; Diabetes Mellitus; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression; Genetic Engineering; Genetic Therapy; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Intestinal Mucosa; Intestines; Mice; Molecular Targeted Therapy; Plasmids; Promoter Regions, Genetic; Transfection | 2011 |
Normalizing action of exendin-4 and GLP-1 in the glucose metabolism of extrapancreatic tissues in insulin-resistant and type 2 diabetic states.
Topics: Adipose Tissue; Animals; Biological Transport; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Transporter Type 2; Glucose Transporter Type 4; Glycogen Synthase; Insulin Resistance; Liver; Male; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Peptides; Phosphatidylinositol 3-Kinases; Rats; Rats, Wistar; Venoms | 2012 |
The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.
Topics: Animals; ATP-Binding Cassette Transporters; Benzofurans; Calcium Signaling; Drug Synergism; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Potassium Channels, Inwardly Rectifying; Rats; Rats, Sprague-Dawley; Receptors, Drug; Receptors, G-Protein-Coupled; Receptors, Glucagon; Sulfones; Sulfonylurea Receptors | 2012 |
Proinsulin, GLP-1, and glucagon are associated with partial remission in children and adolescents with newly diagnosed type 1 diabetes.
Topics: Adolescent; Age of Onset; Blood Glucose; C-Peptide; Child; Child, Preschool; Cohort Studies; Diabetes Mellitus, Type 1; Female; Follow-Up Studies; Glucagon; Glucagon-Like Peptide 1; Humans; Infant; Infant, Newborn; Male; Proinsulin; Remission, Spontaneous | 2012 |
Transmembrane α-helix 2 and 7 are important for small molecule-mediated activation of the GLP-1 receptor.
Topics: Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; HEK293 Cells; Humans; Ligands; Models, Molecular; Peptide Fragments; Protein Structure, Secondary; Receptors, Glucagon | 2011 |
Glucagon-like peptide-1 inhibits insulinotropic effects of oxyntomodulin and glucagon in cattle.
Topics: Animals; Blood Glucose; Cattle; Glucagon; Glucagon-Like Peptide 1; Insulin; Intercellular Signaling Peptides and Proteins; Male; Oxyntomodulin; Peptides | 2012 |
Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Blood Glucose; Body Mass Index; C-Peptide; Diabetes Mellitus, Type 2; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin-Secreting Cells; Male; Middle Aged; Obesity | 2012 |
A pilot study of the efficacy of miglitol and sitagliptin for type 2 diabetes with a continuous glucose monitoring system and incretin-related markers.
Topics: 1-Deoxynojirimycin; Aged; Biomarkers; Blood Glucose; Case-Control Studies; Deoxyglucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycoside Hydrolase Inhibitors; Humans; Hyperglycemia; Hypoglycemic Agents; Incretins; Insulin; Male; Middle Aged; Monitoring, Physiologic; Pilot Projects; Postprandial Period; Pyrazines; Sitagliptin Phosphate; Triazoles | 2011 |
Breakfast skipping in prepubertal obese children: hormonal, metabolic and cognitive consequences.
Topics: Area Under Curve; Attention; Blood Glucose; Carbohydrate Metabolism; Child; Cognition; Cross-Sectional Studies; Diet; Fasting; Feeding Behavior; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Memory; Obesity; Oxidation-Reduction; Peptide YY; Postprandial Period; Verbal Learning | 2012 |
Effects of duodenal-jejunal exclusion on beta cell function and hormonal regulation in Goto-Kakizaki rats.
Topics: Animals; Diabetes Mellitus, Type 2; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Insulin; Insulin-Secreting Cells; Leptin; Male; Models, Animal; Pancreas; Random Allocation; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2012 |
Exendin-4 ameliorates diabetic symptoms through activation of glucokinase.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Enzyme Activation; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Peptides; Venoms | 2012 |
Changes in gastrointestinal hormone responses, insulin sensitivity, and beta-cell function within 2 weeks after gastric bypass in non-diabetic subjects.
Topics: Adult; Appetite; C-Peptide; Cholecystokinin; Confounding Factors, Epidemiologic; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Gastrins; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Leptin; Male; Middle Aged; Obesity, Morbid; Pancreatic Polypeptide; Peptide YY; Postprandial Period; Somatostatin; Time Factors; Weight Loss | 2012 |
Modulation of β-catenin signaling by glucagon receptor activation.
Topics: Animals; beta Catenin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; HEK293 Cells; Hepatocytes; Humans; Low Density Lipoprotein Receptor-Related Protein-5; Low Density Lipoprotein Receptor-Related Protein-6; Mice; Receptors, Glucagon; Signal Transduction; Transfection | 2012 |
Diabetes-associated common genetic variation and its association with GLP-1 concentrations and response to exogenous GLP-1.
Topics: C-Peptide; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Genetic Variation; Genotype; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Clamp Technique; Humans; Hyperglycemia; Insulin; Insulin-Secreting Cells; KCNQ1 Potassium Channel; Membrane Proteins; Transcription Factor 7-Like 2 Protein | 2012 |
Predominant role of active versus facilitative glucose transport for glucagon-like peptide-1 secretion.
Topics: Animals; Biological Transport; Cell Line; Cells, Cultured; Enteroendocrine Cells; Flow Cytometry; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; Intestines; KATP Channels; Mice; Mice, Knockout; Phloretin; Sodium-Glucose Transporter 1 | 2012 |
Plasma concentrations and effects of glucagon-like peptide-1 (7-36) amide in calves before and after weaning.
Topics: Aging; Animal Feed; Animals; Blood Glucose; Cattle; Diet; Fatty Acids, Volatile; Glucagon; Glucagon-Like Peptide 1; Insulin; Male; Milk; Peptide Fragments; Weaning | 2012 |
Abnormal glucose tolerance and insulin secretion in pancreas-specific Tcf7l2-null mice.
Topics: Animals; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Homeostasis; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Knockout; Pancreas; Proinsulin; Transcription Factor 7-Like 2 Protein | 2012 |
Impact of glucagon-like peptide-1 (7-36) amide, isosteviol and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside on leucine-mediated α-cell dysfunction.
Topics: Aminoimidazole Carboxamide; Animals; Cells, Cultured; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Leucine; Mice; Mice, Transgenic; Peptide Fragments; Protein Precursors; Ribonucleosides | 2012 |
GLP-1 and glucagon secretion from a pancreatic neuroendocrine tumor causing diabetes and hyperinsulinemic hypoglycemia.
Topics: Adenoma, Islet Cell; Animals; Cells, Cultured; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Hepatectomy; Humans; Hyperinsulinism; Hypoglycemia; Immunohistochemistry; Male; Mice; Mice, Nude; Middle Aged; Neuroendocrine Tumors; Pancreatectomy; Pancreatic Neoplasms; Real-Time Polymerase Chain Reaction; Splenectomy | 2012 |
Antidiabetic activities of oligosaccharides of Ophiopogonis japonicus in experimental type 2 diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycogen; Hypoglycemic Agents; Liver; Male; Muscle, Skeletal; Oligosaccharides; Ophiopogon; Organ Size; Proteinuria; Rats; Rats, Sprague-Dawley | 2012 |
Effects of long-term treatment with the dipeptidyl peptidase-4 inhibitor vildagliptin on islet endocrine cells in non-obese type 2 diabetic Goto-Kakizaki rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Adamantane; Animals; Apoptosis; Cell Proliferation; Deoxyguanosine; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Eating; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Nitriles; Pyrrolidines; Rats; Time Factors; Vildagliptin | 2012 |
DPP4 inhibitor vildagliptin preserves β-cell mass through amelioration of endoplasmic reticulum stress in C/EBPB transgenic mice.
Topics: Adamantane; Animals; Blood Glucose; CCAAT-Enhancer-Binding Protein-beta; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Endoplasmic Reticulum Stress; Exenatide; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Hyperglycemia; Insulin; Insulin-Secreting Cells; Leupeptins; Mice; Mice, Transgenic; Nitriles; Peptides; Pyrrolidines; Venoms; Vildagliptin | 2012 |
Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele.
Topics: Alleles; Blood Glucose; Female; Gastric Inhibitory Polypeptide; Genotype; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Incretins; Insulin; Male; Middle Aged; Transcription Factor 7-Like 2 Protein; White People | 2013 |
Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice.
Topics: Animals; Enteroendocrine Cells; Extracellular Signal-Regulated MAP Kinases; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Incretins; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Promegestone; Receptors, Progesterone | 2013 |
Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling.
Topics: Adipose Tissue, Brown; Animals; Central Nervous System; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin Resistance; Ion Channels; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Proteins; Nerve Tissue Proteins; Neurons; Oxyntomodulin; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Receptors, Glucagon; Scapula; Signal Transduction; Sympathetic Nervous System; Thermogenesis; Trans-Activators; Transcription Factors; Uncoupling Protein 1; Up-Regulation | 2012 |
A local glucagon-like peptide 1 (GLP-1) system in human pancreatic islets.
Topics: Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Immunohistochemistry; Insulin; Male; Mass Spectrometry; Middle Aged; Pancreas | 2012 |
C-peptide response to glucagon challenge is correlated with improvement of early insulin secretion by liraglutide treatment.
Topics: Adult; Aged; C-Peptide; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Monitoring; Drug Resistance; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; Kinetics; Liraglutide; Male; Middle Aged; Receptors, Glucagon | 2012 |
Automated recognition and quantification of pancreatic islets in Zucker diabetic fatty rats treated with exendin-4.
Topics: Animals; Artificial Intelligence; Diabetes Mellitus, Type 2; Exenatide; Expert Systems; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; High-Throughput Screening Assays; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Obesity; Pattern Recognition, Automated; Peptides; Rats; Rats, Zucker; Somatostatin; Somatostatin-Secreting Cells; Venoms | 2013 |
Hypothalamic brain-derived neurotrophic factor regulates glucagon secretion mediated by pancreatic efferent nerves.
Topics: Animals; Brain-Derived Neurotrophic Factor; Efferent Pathways; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Hypothalamus; Immunohistochemistry; Insulin; Male; Pancreas; Rats; Rats, Sprague-Dawley | 2013 |
Impact of incretin on early-phase insulin secretion and glucose excursion.
Topics: Adult; Blood Glucose; Cohort Studies; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Secretion; Male; Middle Aged | 2013 |
Gastrointestinal factors contribute to glucometabolic disturbances in nondiabetic patients with end-stage renal disease.
Topics: Adult; Analysis of Variance; Area Under Curve; Biomarkers; Blood Glucose; Case-Control Studies; Fasting; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Tract; Glucagon; Glucagon-Like Peptide 1; Glucose Metabolism Disorders; Glucose Tolerance Test; Humans; Incretins; Insulin; Kidney Failure, Chronic; Linear Models; Male; Middle Aged; Time Factors | 2013 |
Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala.
Topics: Amygdala; Animals; Appetite; Brain Stem; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Injections, Intraperitoneal; Male; Mice; Proto-Oncogene Proteins c-fos | 2013 |
GLP-1 action and glucose tolerance in subjects with remission of type 2 diabetes after gastric bypass surgery.
Topics: C-Peptide; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Peptide Fragments | 2013 |
Removal of duodenum elicits GLP-1 secretion.
Topics: Adult; Aged; Aged, 80 and over; Duodenum; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Male; Middle Aged; Pancreaticoduodenectomy | 2013 |
Beta and alpha cell function in metabolically healthy but obese subjects: relationship with entero-insular axis.
Topics: Adult; Area Under Curve; Blood Glucose; C-Peptide; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Obesity | 2013 |
The incretin effect in Korean subjects with normal glucose tolerance or type 2 diabetes.
Topics: Adult; Asian People; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Secretion; Male; Middle Aged; Republic of Korea | 2014 |
Reduced postprandial GLP-1 responses in women with gestational diabetes mellitus.
Topics: Adult; Area Under Curve; Biomarkers; Blood Glucose; Body Mass Index; C-Peptide; Diabetes, Gestational; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycated Hemoglobin; Homeostasis; Humans; Insulin; Insulin Resistance; Insulin Secretion; Postpartum Period; Postprandial Period; Pregnancy | 2013 |
A DPP-IV-resistant triple-acting agonist of GIP, GLP-1 and glucagon receptors with potent glucose-lowering and insulinotropic actions in high-fat-fed mice.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Body Weight; Cricetinae; Cricetulus; Diet, High-Fat; Dipeptidyl Peptidase 4; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; HEK293 Cells; Homeostasis; Humans; Insulin; Insulin Secretion; Male; Mice; Molecular Sequence Data; Peptides; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 2013 |
Endoscopic duodenal-jejunal bypass liner rapidly improves type 2 diabetes.
Topics: Adolescent; Adult; Aged; Area Under Curve; Bariatric Surgery; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Duodenum; Eating; Endoscopy; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Insulin; Insulin Secretion; Jejunum; Male; Middle Aged; Netherlands; Obesity; Pilot Projects; Postprandial Period; Remission Induction; Time Factors; Treatment Outcome; Weight Loss | 2013 |
Direct effects of exendin-(9,39) and GLP-1-(9,36)amide on insulin action, β-cell function, and glucose metabolism in nondiabetic subjects.
Topics: Adult; Blood Glucose; Body Mass Index; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin-Secreting Cells; Male; Peptide Fragments; Peptides | 2013 |
GLP-1 and the long-term outcome of type 2 diabetes mellitus after Roux-en-Y gastric bypass surgery in morbidly obese subjects.
Topics: Absorptiometry, Photon; Aged; Biomarkers; Blood Glucose; Body Composition; C-Peptide; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Obesity, Morbid; Treatment Outcome | 2013 |
Effects of short-term intensive glycemic control on insulin, glucagon, and glucagon-like peptide-1 secretion in patients with Type 2 diabetes.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Male; Middle Aged | 2013 |
Exaggerated glucagon-like peptide 1 response is important for improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Gastric Bypass; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin Resistance; Insulin-Secreting Cells; Male; Middle Aged; Peptide Fragments; Receptors, Glucagon | 2013 |
Beneficial effects of parenteral GLP-1 delivery by cell therapy in insulin-deficient streptozotocin diabetic mice.
Topics: Animals; Blood Glucose; Body Weight; Cell Line; Cell Transplantation; Diabetes Mellitus, Experimental; Eating; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, SCID; Streptozocin | 2013 |
Preserved GLP-1 and exaggerated GIP secretion in type 2 diabetes and relationships with triglycerides and ALT.
Topics: Adult; Aged; Alanine Transaminase; Area Under Curve; Biomarkers; Diabetes Mellitus, Type 2; Eating; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Incretins; Lipid Metabolism; Male; Middle Aged; Triglycerides | 2013 |
Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet.
Topics: Animals; Blood Glucose; Body Weight; Cell Dedifferentiation; Densitometry; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Dietary Sucrose; Disease Models, Animal; Fluorescent Antibody Technique; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose Tolerance Test; Glycated Hemoglobin; Homeobox Protein Nkx-2.2; Homeodomain Proteins; Insulin; Insulin Resistance; Insulin-Secreting Cells; Islets of Langerhans; Macaca mulatta; Nuclear Proteins; Protective Agents; Resveratrol; Sirtuin 1; Stilbenes; Transcription Factors | 2013 |
Long-term liraglutide treatment is associated with increased insulin content and secretion in β-cells, and a loss of α-cells in ZDF rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Liraglutide; Male; Rats; Rats, Zucker | 2013 |
Phenotypic characterization of GPR120-expressing cells in the interstitial tissue of pancreas.
Topics: Actins; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Line; Fatty Acids, Unsaturated; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Humans; Macrophages; Pancreas; Rats; Receptors, G-Protein-Coupled; Tissue Distribution; Vimentin | 2013 |
Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo.
Topics: Adult; Arteries; Calcium Gluconate; Food; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucagonoma; Humans; Injections, Intra-Arterial; Male; Middle Aged; Multiple Endocrine Neoplasia Type 1; Pancreatectomy | 2013 |
Roux-en-Y gastric bypass and sleeve gastrectomy: mechanisms of diabetes remission and role of gut hormones.
Topics: Adult; Diabetes Mellitus, Type 2; Female; Gastrectomy; Gastric Bypass; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glycemic Index; Humans; Insulin; Insulin Resistance; Insulin-Secreting Cells; Islet Amyloid Polypeptide; Male; Middle Aged; Obesity, Morbid; Pancreatic Polypeptide; Peptide YY; Remission Induction | 2013 |
Postprandial responses of incretin and pancreatic hormones in non-diabetic patients with end-stage renal disease.
Topics: Adult; Blood Glucose; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Kidney Failure, Chronic; Male; Middle Aged; Pancreatic Hormones; Postprandial Period | 2014 |
A novel glucagon-like peptide-1 (GLP-1)/glucagon hybrid peptide with triple-acting agonist activity at glucose-dependent insulinotropic polypeptide, GLP-1, and glucagon receptors and therapeutic potential in high fat-fed mice.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Cyclic AMP; Diet, High-Fat; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin Resistance; Insulin Secretion; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Molecular Sequence Data; Obesity; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Recombinant Fusion Proteins | 2013 |
Glucagon response to oral glucose challenge in type 1 diabetes: lack of impact of euglycemia.
Topics: Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Diabetes Mellitus, Type 1; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Glycerol Kinase; Humans; Hypoadrenocorticism, Familial; Incretins; Male; Middle Aged | 2014 |
Co-agonist of glucagon and GLP-1 reduces cholesterol and improves insulin sensitivity independent of its effect on appetite and body weight in diet-induced obese C57 mice.
Topics: Animals; Appetite; Body Weight; Cholesterol; Cholesterol, LDL; Diet; Eating; Fibroblast Growth Factors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Gluconeogenesis; Insulin Resistance; Leptin; Lipid Metabolism; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Receptors, Glucagon; Triglycerides | 2013 |
Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass.
Topics: Adult; Blood Glucose; Case-Control Studies; Female; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Humans; Hypoglycemia; Insulin; Insulin-Secreting Cells; Male; Middle Aged; Peptide Fragments; Receptors, Glucagon; Treatment Outcome | 2014 |
The glycemic/metabolic responses to meal tolerance tests at breakfast, lunch and dinner, and effects of the mitiglinide/voglibose fixed-dose combination on postprandial profiles in Japanese patients with type 2 diabetes mellitus.
Topics: Aged; Blood Glucose; Breakfast; C-Reactive Protein; Diabetes Mellitus, Type 2; Drug Combinations; Fatty Acids, Nonesterified; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Hypoglycemic Agents; Inositol; Insulin; Isoindoles; Lunch; Male; Meals; Middle Aged; Postprandial Period; Triglycerides | 2014 |
[The effects of gastric bypass procedures on blood glucose, gastric inhibitory polypeptide and glucagon-like peptide-1 of normal glucose tolerance dogs].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dogs; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin | 2013 |
Intracerebroventricular administration of novel glucagon-like peptide suppresses food intake in chicks.
Topics: Animals; Appetite Depressants; Blood Glucose; Brain; Chickens; Corticosterone; Eating; Glucagon; Glucagon-Like Peptide 1; Incretins; Male; Oxyntomodulin; Receptors, Corticotropin-Releasing Hormone | 2014 |
GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet.
Topics: Animals; Diet, High-Fat; Eating; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Polyethylene Glycols; Receptors, Glucagon; Weight Loss | 2014 |
Effect of sitagliptin treatment on metabolism and cardiac function in genetic diabetic mice.
Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Diabetes Mellitus; Diet, High-Fat; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Heart; Heart Function Tests; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Myocardium; Pyrazines; Sitagliptin Phosphate; Triazoles | 2014 |
An accidental liraglutide overdose: case report.
Topics: Accidents; Blood Glucose; Drug Overdose; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Secretion; Liraglutide; Middle Aged; Nausea; Treatment Outcome; Vomiting | 2014 |
GLP-1 receptor localization in monkey and human tissue: novel distribution revealed with extensively validated monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Blood Pressure; Body Weight; Cell Line; Cricetinae; Duodenum; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Haplorhini; Heart Rate; Humans; Insulin; Insulin Secretion; Ligands; Liraglutide; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptides; Protein Binding; Receptors, Glucagon; Tissue Distribution; Transfection; Venoms | 2014 |
Gastric bypass improves β-cell function and increases β-cell mass in a porcine model.
Topics: Animals; Blood Glucose; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin-Secreting Cells; Male; Obesity, Morbid; Swine | 2014 |
Glucose-induced glucagon-like Peptide 1 secretion is deficient in patients with non-alcoholic fatty liver disease.
Topics: Case-Control Studies; Fatty Liver; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Male; Middle Aged; Non-alcoholic Fatty Liver Disease | 2014 |
Progressive change of intra-islet GLP-1 production during diabetes development.
Topics: Algorithms; Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Progression; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Immunohistochemistry; Islets of Langerhans; Male; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Mutant Strains; Prediabetic State; Proprotein Convertase 1; Up-Regulation | 2014 |
Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans.
Topics: Administration, Oral; Adult; Animals; Blood Glucose; Cell Line; Cholecystokinin; Dietary Carbohydrates; Dose-Response Relationship, Drug; Enteroendocrine Cells; Female; Fructose; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Intestinal Mucosa; Intestines; Ion Channel Gating; KATP Channels; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; Single-Blind Method; Time Factors; Young Adult | 2014 |
GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans.
Topics: Adolescent; Adult; Blood Flow Velocity; Blood Volume; Coronary Vessels; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Microvessels; Muscle, Skeletal; Regional Blood Flow | 2014 |
Incretin effect and glucagon responses to oral and intravenous glucose in patients with maturity-onset diabetes of the young--type 2 and type 3.
Topics: Administration, Intravenous; Administration, Oral; Adult; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucokinase; Glucose; Hepatocyte Nuclear Factor 1-alpha; Humans; Incretins; Insulin Resistance; Male; Middle Aged | 2014 |
Small intestinal glucose exposure determines the magnitude of the incretin effect in health and type 2 diabetes.
Topics: Animals; Blood Glucose; Body Mass Index; C-Peptide; Case-Control Studies; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Incretins; Insulin; Male | 2014 |
Alogliptin improves steroid-induced hyperglycemia in treatment-naïve Japanese patients with chronic kidney disease by decrease of plasma glucagon levels.
Topics: Aged; Asian People; Body Mass Index; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hyperglycemia; Japan; Kidney Function Tests; Male; Piperidines; Regression Analysis; Renal Insufficiency, Chronic; Steroids; Uracil; Vital Signs | 2014 |
Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity.
Topics: Animals; beta-Endorphin; Cells, Cultured; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; HEK293 Cells; Humans; Hyperalgesia; Microglia; Neuralgia; Nociception; Peptide Fragments; Peptides; Posterior Horn Cells; Rats; Rats, Wistar; Receptors, Glucagon; Venoms | 2014 |
Two dipolar α-helices within hormone-encoding regions of proglucagon are sorting signals to the regulated secretory pathway.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Mesocricetus; Microscopy, Confocal; Models, Molecular; Molecular Sequence Data; Open Reading Frames; PC12 Cells; Peptides; Proglucagon; Protein Processing, Post-Translational; Protein Structure, Secondary; Protein Transport; Rats; Secretory Pathway; Secretory Vesicles; Signal Transduction | 2014 |
Evidence from a single individual that increased plasma GLP-1 and GLP-1-stimulated insulin secretion after gastric bypass are independent of foregut exclusion.
Topics: Blood Glucose; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Postprandial Period | 2014 |
Role of endogenous GLP-1 and GIP in beta cell compensatory responses to insulin resistance and cellular stress.
Topics: Animals; Apoptosis; Cell Proliferation; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Hormones; Hydrocortisone; Insulin Resistance; Insulin-Secreting Cells; Islets of Langerhans; Lymphocytes; Male; Mice; Mice, Knockout; Pancreas; Protein Transport; Streptozocin | 2014 |
Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): implications for GLP-1 measurements in clinical studies.
Topics: Amino Acid Sequence; Enzyme-Linked Immunosorbent Assay; Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments; Radioimmunoassay; Sensitivity and Specificity | 2014 |
Islet remodeling in female mice with spontaneous autoimmune and streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Immunohistochemistry; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice, Inbred BALB C; Mice, Inbred NOD; Somatostatin | 2014 |
The effect of glucagon-like peptide-1 in the management of diabetes mellitus: cellular and molecular mechanisms.
Topics: Animals; Blood Glucose; Body Weight; Catalase; Diabetes Mellitus, Experimental; Exenatide; Fluorescent Antibody Technique; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glutathione Reductase; Insulin; Insulin Secretion; Islets of Langerhans; Kidney; Lipids; Liver; Male; Peptides; Rats, Wistar; Time Factors; Venoms | 2014 |
Comparison of stability, cellular, glucose-lowering and appetite supressing effects of oxyntomodulin analogues modified at the N-terminus.
Topics: Animals; Appetite; Blood Glucose; Cyclic AMP; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Half-Life; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Oxyntomodulin; Peptides; Receptors, Glucagon | 2014 |
Resveratrol ameliorates mitochondrial dysfunction but increases the risk of hypoglycemia following hemorrhagic shock.
Topics: Animals; Blood Glucose; Corticosterone; Glucagon; Glucagon-Like Peptide 1; Hypoglycemia; Insulin; Insulin Resistance; Kidney; Male; Mitochondria; Mitochondria, Liver; Rats, Long-Evans; Reactive Oxygen Species; Resuscitation; Resveratrol; Shock, Hemorrhagic; Stilbenes | 2014 |
Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.
Topics: Animals; Animals, Newborn; Blood Glucose; Cell Proliferation; Diabetes, Gestational; Disease Models, Animal; Female; Glucagon; Glucagon-Like Peptide 1; Hyperglycemia; Hyperinsulinism; Insulin; Insulin Resistance; Insulin-Secreting Cells; Islets of Langerhans; Leptin; Mice; Organ Size; Phenotype; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Weight Gain | 2014 |
Teneligliptin improves glycemic control with the reduction of postprandial insulin requirement in Japanese diabetic patients.
Topics: Aged; Blood Glucose; Combined Modality Therapy; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Hypoglycemia; Hypoglycemic Agents; Insulin; Insulin Resistance; Japan; Middle Aged; Monitoring, Ambulatory; Postprandial Period; Pyrazoles; Thiazolidines | 2015 |
Absence of glucagon and insulin action reveals a role for the GLP-1 receptor in endogenous glucose production.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Immunohistochemistry; Insulin; Mice; Mice, Knockout; Receptors, Glucagon; Streptozocin | 2015 |
Conditional glucagon receptor overexpression has multi-faceted consequences for beta-cell function.
Topics: Animals; Arginine; Body Weight; Carbachol; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Transgenic; Receptors, Glucagon; Receptors, Muscarinic | 2014 |
Clearance of glucoregulatory peptide hormones during haemodialysis and haemodiafiltration in non-diabetic end-stage renal disease patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Diabetes Mellitus; Dialysis Solutions; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Hemodiafiltration; Humans; Insulin; Kidney Failure, Chronic; Male; Middle Aged; Postprandial Period; Renal Dialysis; Young Adult | 2015 |
Selective disruption of Tcf7l2 in the pancreatic β cell impairs secretory function and lowers β cell mass.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Gene Deletion; Genetic Loci; Genome-Wide Association Study; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin Secretion; Insulin-Secreting Cells; Integrases; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Weight; Pancreas; Polymorphism, Single Nucleotide; Receptors, Glucagon; Transcription Factor 7-Like 2 Protein; Wnt Signaling Pathway | 2015 |
Cannabinoid receptor 1 antagonist treatment induces glucagon release and shows an additive therapeutic effect with GLP-1 agonist in diet-induced obese mice.
Topics: Animals; Anti-Obesity Agents; Blood Glucose; Body Weight; Diet, High-Fat; Drug Synergism; Eating; Exenatide; Glucagon; Glucagon-Like Peptide 1; Insulin Resistance; Male; Mice, Inbred C57BL; Mice, Obese; Obesity; Peptides; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Venoms | 2014 |
Incretin and islet hormone responses to meals of increasing size in healthy subjects.
Topics: Adult; Blood Glucose; C-Peptide; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Healthy Volunteers; Humans; Insulin; Male; Meals; Postprandial Period; Young Adult | 2015 |
Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes.
Topics: Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Exercise; Fasting; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Hyperglycemia; Infusions, Intravenous; Injections; Insulin; Insulin Secretion; Male; Pancreas; Treatment Outcome | 2015 |
[The physiology of glucagon-like peptide-1 and its role in the pathophysiology of type 2 diabetes mellitus].
Topics: Animals; Blood Glucose; Carbohydrate Metabolism, Inborn Errors; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Eating; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Homeostasis; Humans; Hyperglycemia; Incretins; Insulin; Insulin Secretion; Insulin-Secreting Cells; Malabsorption Syndromes; Mice; Mice, Knockout; Models, Biological; Obesity; Receptors, Glucagon | 2014 |
Insulin-independent actions of glucagon-like peptide-1 in wethers.
Topics: Adipose Tissue; Amino Acids, Branched-Chain; Animals; Blood Glucose; Blood Urea Nitrogen; Cholesterol; Fatty Acids, Nonesterified; Glucagon; Glucagon-Like Peptide 1; Goats; Infusions, Intravenous; Insulin; Insulin Antagonists; Lactic Acid; Lipid Metabolism; Liver; Male; Triglycerides | 2015 |
Protective effects of pioglitazone and/or liraglutide on pancreatic β-cells in db/db mice: Comparison of their effects between in an early and advanced stage of diabetes.
Topics: Animals; Apoptosis; Blood Glucose; Caspases; Cell Proliferation; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Ki-67 Antigen; Liraglutide; Male; Mice; Mice, Transgenic; Organ Size; Pioglitazone; Proto-Oncogene Proteins c-bcl-2; RNA, Ribosomal, 18S; Thiazolidinediones; Time Factors; Triglycerides | 2015 |
Pharmacology of the glucagon-like peptide-1 analog exenatide extended-release in healthy cats.
Topics: Animals; Blood Glucose; Cat Diseases; Cats; Diabetes Mellitus; Drug Synergism; Exenatide; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Clamp Technique; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Microspheres; Peptides; Venoms | 2015 |
Pharmacokinetics and pharmacodynamics of the glucagon-like peptide-1 analog liraglutide in healthy cats.
Topics: Animals; Appetite; Blood Glucose; Cats; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Clamp Technique; Hyperglycemia; Hypoglycemic Agents; Insulin; Liraglutide; Male; Weight Loss | 2015 |
Evidence That in Uncontrolled Diabetes, Hyperglucagonemia Is Required for Ketosis but Not for Increased Hepatic Glucose Production or Hyperglycemia.
Topics: Animals; Diabetes Mellitus, Experimental; Forkhead Box Protein O1; Forkhead Transcription Factors; Glucagon; Glucagon-Like Peptide 1; Glucose; Hyperglycemia; Insulin; Ketone Bodies; Ketosis; Liraglutide; Liver; Male; Rats, Wistar; Receptors, Glucagon; Streptozocin | 2015 |
Functional GIP receptors play a major role in islet compensatory response to high fat feeding in mice.
Topics: Adaptation, Physiological; Adiposity; Animals; Apoptosis; Blood Glucose; Cell Proliferation; Diet, High-Fat; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Resistance; Intestinal Mucosa; Islets of Langerhans; Male; Mice, Inbred C57BL; Mice, Knockout; Receptors, Gastrointestinal Hormone; Time Factors | 2015 |
Incretin and glucagon levels in adult offspring exposed to maternal diabetes in pregnancy.
Topics: Adolescent; Adult; Adult Children; Diabetes Mellitus, Type 1; Diabetes, Gestational; Female; Follow-Up Studies; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Male; Pregnancy; Prenatal Exposure Delayed Effects; Young Adult | 2015 |
The effects of exendin-4 treatment on graft failure: an animal study using a novel re-vascularized minimal human islet transplant model.
Topics: Animals; Apoptosis; Blood Glucose; C-Peptide; Cell Count; Diabetes Mellitus, Experimental; Exenatide; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Graft Survival; Humans; Hyperglycemia; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice, Inbred BALB C; Models, Animal; Peptides; Venoms | 2015 |
Glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis.
Topics: Animals; Animals, Genetically Modified; Cell Proliferation; Cell Transdifferentiation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Insulin-Secreting Cells; Pancreas; Zebrafish | 2015 |
Incretin secretion in obese Korean children and adolescents with newly diagnosed type 2 diabetes.
Topics: Adolescent; Analysis of Variance; Asian People; Blood Glucose; Body Mass Index; C-Peptide; Case-Control Studies; Child; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Resistance; Male; Obesity; Republic of Korea | 2016 |
Improvement of glycemic control in streptozotocin-induced diabetic rats by Atlantic salmon skin gelatin hydrolysate as the dipeptidyl-peptidase IV inhibitor.
Topics: Animals; British Columbia; Diabetes Mellitus, Type 2; Dietary Supplements; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Endopeptidases; Fish Proteins; Food-Processing Industry; Gelatin; Glucagon; Glucagon-Like Peptide 1; Hyperglycemia; Industrial Waste; Insulin; Insulin Secretion; Male; Protein Hydrolysates; Rats, Sprague-Dawley; Salmo salar; Skin | 2015 |
Effects of Fat and Protein Preloads on Pouch Emptying, Intestinal Transit, Glycaemia, Gut Hormones, Glucose Absorption, Blood Pressure and Gastrointestinal Symptoms After Roux-en-Y Gastric Bypass.
Topics: Blood Glucose; Blood Pressure; Dietary Fats; Dietary Proteins; Female; Gastric Bypass; Gastrointestinal Transit; Glucagon; Glucagon-Like Peptide 1; Heart Rate; Humans; Insulin; Male; Middle Aged; Nausea; Water | 2016 |
Acoustic Dispensing Preserves the Potency of Therapeutic Peptides throughout the Entire Drug Discovery Workflow.
Topics: Acoustics; Biomedical Technology; Drug Discovery; Drug Evaluation, Preclinical; Glucagon; Glucagon-Like Peptide 1; Solutions; Structure-Activity Relationship; Workflow | 2016 |
KBP-042 improves bodyweight and glucose homeostasis with indices of increased insulin sensitivity irrespective of route of administration.
Topics: Adiposity; Animals; Blood Glucose; Body Weight; Calcitonin; Diet, High-Fat; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Insulin Resistance; Intra-Abdominal Fat; Islet Amyloid Polypeptide; Leptin; Male; Peptides; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin | 2015 |
Comparative analysis of glucagonergic cells, glia, and the circumferential marginal zone in the reptilian retina.
Topics: Amphibians; Animals; Cell Proliferation; Chickens; Female; Fishes; Glucagon; Glucagon-Like Peptide 1; Lizards; Male; Neuroglia; Retina; Snakes; Species Specificity; Turtles | 2016 |
Glucagon and GLP-1 exhibit no synergistic enhancement of glucose-stimulated insulin secretion in mice.
Topics: Animals; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Mice | 2015 |
Glucose metabolism alterations in patients with bipolar disorder.
Topics: Biomarkers; Bipolar Disorder; Blood Glucose; C-Peptide; Case-Control Studies; Female; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Leptin; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Plasminogen Activator Inhibitor 1; Resistin | 2015 |
Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides.
Topics: Animals; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Green Fluorescent Proteins; Humans; Immunohistochemistry; Islets of Langerhans; Liver Neoplasms; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Confocal; Neuroendocrine Tumors; Pancreatic Neoplasms; Proglucagon; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Glucose Tolerance Test; Insulin-Secreting Cells; Mice; Postprandial Period; Receptors, G-Protein-Coupled | 2015 |
Degradation and Stabilization of Peptide Hormones in Human Blood Specimens.
Topics: Amino Acid Sequence; Dipeptidyl Peptidase 4; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Molecular Sequence Data; Oxyntomodulin; Peptide Fragments; Peptide Hormones; Protein Stability; Proteolysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
Mathematical modelling of local calcium and regulated exocytosis during inhibition and stimulation of glucagon secretion from pancreatic alpha-cells.
Topics: Animals; Calcium; Epinephrine; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Mice; Models, Biological | 2015 |
Ileal Transposition Decreases Plasma Lipopolysaccharide Levels in Association with Increased L Cell Secretion in Non-obese Non-diabetic Rats.
Topics: Animals; Blood Glucose; Body Weight; Drinking; Eating; Enteroendocrine Cells; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucose Tolerance Test; Ileum; Insulin Resistance; Lipopolysaccharides; Male; Obesity, Morbid; Peptide YY; Rats, Sprague-Dawley | 2016 |
Mixed meal ingestion diminishes glucose excursion in comparison with glucose ingestion via several adaptive mechanisms in people with and without type 2 diabetes.
Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Blood Glucose; C-Peptide; Case-Control Studies; Diabetes Mellitus, Type 2; Dietary Fats; Dietary Proteins; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Healthy Volunteers; Humans; Incretins; Insulin; Insulin-Secreting Cells; Male; Meals; Middle Aged; Postprandial Period | 2016 |
Immunohistochemical, apoptotic and biochemical changes by dipeptidyl peptidase-4 inhibitor-sitagliptin in type-2 diabetic rats.
Topics: Animals; Animals, Newborn; Apoptosis; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Rats; Rats, Wistar; Sitagliptin Phosphate; Somatostatin | 2015 |
Multiplexed Quantification of Proglucagon-Derived Peptides by Immunoaffinity Enrichment and Tandem Mass Spectrometry after a Meal Tolerance Test.
Topics: Animals; Chromatography, High Pressure Liquid; Fasting; Glucagon; Glucagon-Like Peptide 1; Humans; Immunoassay; Mice; Mice, Inbred BALB C; Oxyntomodulin; Tandem Mass Spectrometry | 2016 |
Postprandial glucose, insulin, and glucagon-like peptide-1 responses of different equine breeds adapted to meals containing micronized maize.
Topics: Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Blood Glucose; Breeding; Diet; Food Handling; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Horses; Insulin; Insulin Resistance; Postprandial Period; Zea mays | 2015 |
Role of the Entero-Insular Axis in the Pathogenesis of Idiopathic Reactive Hypoglycemia: A Pilot Study.
Topics: Adult; Blood Glucose; Cross-Sectional Studies; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Male; Pilot Projects | 2015 |
Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Immunohistochemistry; Incretins; Insulin-Secreting Cells; Male; Middle Aged; Pancreatic Ducts; Proinsulin; Young Adult | 2015 |
Acute disruption of glucagon secretion or action does not improve glucose tolerance in an insulin-deficient mouse model of diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diphtheria Toxin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose Intolerance; Glucose Tolerance Test; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Glucagon; Streptozocin | 2016 |
Effects of glucagon-like peptide-1 on glucagon secretion in patients with non-alcoholic fatty liver disease.
Topics: Adult; Aged; Energy Metabolism; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Secretion; Lipolysis; Liver; Male; Middle Aged; Non-alcoholic Fatty Liver Disease | 2016 |
Evidence of Extrapancreatic Glucagon Secretion in Man.
Topics: Aged; Blood Glucose; Case-Control Studies; Cholecystokinin; Chromatography, Liquid; Enzyme-Linked Immunosorbent Assay; Female; Gastric Inhibitory Polypeptide; Gastrins; Gastrointestinal Tract; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Glucose Tolerance Test; Humans; Male; Middle Aged; Pancreatectomy; Pancreatic Neoplasms; Pancreatitis; Peptide Fragments; Proteomics; Radioimmunoassay; Tandem Mass Spectrometry | 2016 |
Defective insulin secretion by chronic glucagon receptor activation in glucose intolerant mice.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Glucose Tolerance Test; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Receptors, Glucagon | 2016 |
Proglucagon-Derived Peptides Do Not Significantly Affect Acute Exocrine Pancreas in Rats.
Topics: Actins; Amylases; Animals; Cell Line, Tumor; Cells, Cultured; Exenatide; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Injections, Intravenous; Ki-67 Antigen; Male; Oxyntomodulin; Pancreas, Exocrine; Peptides; Proglucagon; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Venoms | 2016 |
Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes.
Topics: Adolescent; Blood Glucose; Case-Control Studies; Child; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Glucose Tolerance Test; Humans; Male; Pediatric Obesity; Sweden | 2016 |
Establishment of a Refined Oral Glucose Tolerance Test in Pigs, and Assessment of Insulin, Glucagon and Glucagon-Like Peptide-1 Responses.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin | 2016 |
Vasodilator Effect of Glucagon: Receptorial Crosstalk Among Glucagon, GLP-1, and Receptor for Glucagon and GLP-1.
Topics: Animals; Aorta; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Endothelium, Vascular; Gasotransmitters; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; In Vitro Techniques; Insulin; Ion Channels; Male; Membrane Transport Proteins; NADPH Oxidases; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Glucagon; Vasodilation; Vasodilator Agents | 2016 |
Co-culture of clonal beta cells with GLP-1 and glucagon-secreting cell line impacts on beta cell insulin secretion, proliferation and susceptibility to cytotoxins.
Topics: Animals; Cell Line; Cell Proliferation; Coculture Techniques; Cytotoxins; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice | 2016 |
The insulinotropic effect of exogenous glucagon-like peptide-1 is not affected by acute vagotomy in anaesthetized pigs.
Topics: Animals; Blood Glucose; Dipeptidyl Peptidase 4; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin-Secreting Cells; Peptide Fragments; Swine; Vagotomy; Vagus Nerve | 2016 |
Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R).
Topics: Amino Acid Sequence; Animals; Binding Sites; CHO Cells; Cricetulus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; HEK293 Cells; Humans; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Structure, Tertiary | 2016 |
GPR119 Agonist AS1269574 Activates TRPA1 Cation Channels to Stimulate GLP-1 Secretion.
Topics: Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cymenes; Endoplasmic Reticulum; Ethanolamines; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; HEK293 Cells; Humans; Ion Channel Gating; Isothiocyanates; Luciferases; Monoterpenes; Mutant Proteins; Proglucagon; Pyrimidines; Rats; Receptors, G-Protein-Coupled; Recombinant Proteins; Transfection; TRPA1 Cation Channel | 2016 |
PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery.
Topics: Adult; Animals; Diabetes Mellitus, Type 2; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide YY; Rats, Wistar; Transcription, Genetic | 2016 |
A Placebo-Controlled Study on the Effects of the Glucagon-Like Peptide-1 Mimetic, Exenatide, on Insulin Secretion, Body Composition and Adipokines in Obese, Client-Owned Cats.
Topics: Absorptiometry, Photon; Adipokines; Adiponectin; Animals; Body Composition; Cats; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Leptin; Male; Obesity; Peptides; Venoms | 2016 |
Novel dual agonist peptide analogues derived from dogfish glucagon show promising in vitro insulin releasing actions and antihyperglycaemic activity in mice.
Topics: Animals; Cell Line; Cricetinae; Dogfish; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; HEK293 Cells; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptides; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 2016 |
Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.
Topics: Amino Acid Sequence; Amino Acid Substitution; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; HEK293 Cells; Humans; Models, Molecular; Mutagenesis, Site-Directed; Protein Domains; Receptors, G-Protein-Coupled; Receptors, Glucagon; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Signal Transduction | 2016 |
The between-day reproducibility of fasting, satiety-related analytes, in 8 to 11year-old boys.
Topics: Biomarkers; Blood Chemical Analysis; Blood Glucose; Body Composition; Child; Fasting; Fingers; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Leptin; Male; Overweight; Peptide Fragments; Regression Analysis; Reproducibility of Results; Satiation | 2016 |
The Shape of the Glucose Response Curve During an Oral Glucose Tolerance Test Heralds Biomarkers of Type 2 Diabetes Risk in Obese Youth.
Topics: Adiposity; Adolescent; Biomarkers; Blood Glucose; Body Composition; Body Mass Index; C-Peptide; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Incretins; Insulin; Insulin Secretion; Male; Pediatric Obesity; Risk Factors | 2016 |
Reduced β-Cell Secretory Capacity in Pancreatic-Insufficient, but Not Pancreatic-Sufficient, Cystic Fibrosis Despite Normal Glucose Tolerance.
Topics: Adolescent; Adult; C-Peptide; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin-Secreting Cells; Male; Middle Aged; Pancreas; Proinsulin; Young Adult | 2017 |
Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Enteroendocrine Cells; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Hyperglycemia; Insulin-Secreting Cells; Male; Mice, Inbred C57BL; Mice, Transgenic; Obesity; Peptide Fragments; Phenotype | 2016 |
Beneficial Metabolic Effects of Duodenal Jejunal Bypass Liner for the Treatment of Adipose Patients with Type 2 Diabetes Mellitus: Analysis of Responders and Non-Responders.
Topics: Adiposity; Adult; Aged; Bariatric Surgery; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Duodenum; Female; Follow-Up Studies; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Secretion; Jejunum; Male; Middle Aged; Obesity, Morbid; Treatment Outcome; Weight Loss | 2016 |
Insulin resistance, glucagon-like peptide-1 and factors influencing glucose homeostasis in neonates.
Topics: Blood Glucose; C-Peptide; Female; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Humans; Infant, Newborn; Infant, Premature; Insulin; Insulin Resistance; Intensive Care Units, Neonatal; Male; New Zealand | 2017 |
Multifunctional Antibody Agonists Targeting Glucagon-like Peptide-1, Glucagon, and Glucose-Dependent Insulinotropic Polypeptide Receptors.
Topics: Animals; Antibodies; Body Weight; Female; Glucagon; Glucagon-Like Peptide 1; Half-Life; HEK293 Cells; Humans; Immunoglobulin Heavy Chains; Immunoglobulin Light Chains; Mice; Mice, Obese; Peptides; Protein Engineering; Rats; Rats, Sprague-Dawley; Receptors, Gastrointestinal Hormone; Recombinant Fusion Proteins | 2016 |
Acute Reduction of Incretin Effect and Glucose Intolerance in Rats by Single Intragastric Administration of 3-deoxyglucosone.
Topics: Animals; Cyclic AMP; Deoxyglucose; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Incretins; Insulin; Male; Mice; Prediabetic State; Rats | 2017 |
Associations between changes in glucagon-like peptide-1 and bodyweight reduction in patients receiving acarbose or metformin treatment.
Topics: Acarbose; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Patient Education as Topic; Weight Loss | 2017 |
Mice with Deletion of Neuromedin B Receptor Exhibit Decreased Oral Glucose-Stimulated Insulin Release.
Topics: Administration, Oral; Animals; Fasting; Female; Gene Deletion; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Homeostasis; Insulin; Islets of Langerhans; Male; Mice, Inbred C57BL; Mice, Knockout; Neurokinin B; Receptors, Bombesin | 2016 |
Structural Mapping and Functional Characterization of Zebrafish Class B G-Protein Coupled Receptor (GPCR) with Dual Ligand Selectivity towards GLP-1 and Glucagon.
Topics: Amino Acid Sequence; Animals; Glucagon; Glucagon-Like Peptide 1; Ligands; Receptors, G-Protein-Coupled; Sequence Homology, Amino Acid; Zebrafish | 2016 |
Heparanase Overexpression Induces Glucagon Resistance and Protects Animals From Chemically Induced Diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Fibroblast Growth Factors; Glucagon; Glucagon-Like Peptide 1; Glucuronidase; Hyperglycemia; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Streptozocin | 2017 |
Metabolic Dysregulation in Hepacivirus Infection of Common Marmosets (Callithrix jacchus).
Topics: Animals; Blood Glucose; Callithrix; Female; Glucagon; Glucagon-Like Peptide 1; Hepatitis C, Chronic; Insulin; Lipid Metabolism; Liver; Male; Metabolic Diseases | 2017 |
Hybrid peptides in the landscape of drug discovery.
Topics: Animals; Diabetes Mellitus, Type 2; Drug Discovery; Estrogens; Glucagon; Glucagon-Like Peptide 1; Humans; Ligands; Models, Animal; Obesity; Peptide Hormones; Recombinant Fusion Proteins | 2017 |
Dipeptidyl peptidase-4 inhibitor treatment induces a greater increase in plasma levels of bioactive GIP than GLP-1 in non-diabetic subjects.
Topics: Adult; Blood Glucose; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Male; Peptide Fragments; Protein Isoforms; Sensitivity and Specificity | 2017 |
Gastric bypass in the pig increases GIP levels and decreases active GLP-1 levels.
Topics: Animals; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Insulin Resistance; Obesity; Sus scrofa | 2017 |
β-Cell Inactivation of
Topics: Adipokines; Animals; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Gene Expression Profiling; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Incretins; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Male; Mice, Knockout; Oxadiazoles; Pyrimidines; Receptors, G-Protein-Coupled | 2017 |
Association between urinary metabolic profile and the intestinal effects of cocoa in rats.
Topics: Amino Acids; Animals; Body Weight; Cacao; Diet; Dietary Fiber; Energy Metabolism; Feces; Female; Gastrointestinal Microbiome; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Hormones; Immunoglobulin A; Intestines; Leptin; Metabolome; Rats; Rats, Wistar; Urine | 2017 |
Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis.
Topics: Adaptation, Physiological; Aging; Animals; Diet, High-Fat; Diphtheria Toxin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Glucose Intolerance; Glucose Tolerance Test; Homeostasis; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice, Inbred C57BL; Mice, Knockout; Obesity; Proprotein Convertases; Rats; Stress, Physiological | 2017 |
Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Incretins; Insulin; Mice; Pancreas; Peptide Fragments | 2017 |
The activity of the rectal gland of the North Pacific spiny dogfish Squalus suckleyi is glucose dependent and stimulated by glucagon-like peptide-1.
Topics: Animals; Chlorides; Exocrine Glands; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Lactic Acid; Male; Rectum; Sodium-Glucose Transporter 1; Squalus | 2017 |
Design of Novel Exendin-Based Dual Glucagon-like Peptide 1 (GLP-1)/Glucagon Receptor Agonists.
Topics: Amino Acid Sequence; Animals; Blood Glucose; Body Weight; Drug Design; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hypoglycemic Agents; Mice, Inbred C57BL; Mice, Obese; Molecular Docking Simulation; Obesity; Peptides; Structure-Activity Relationship; Swine; Venoms | 2017 |
GLP-1 and GIP Levels in Patients With Hyperthyroidism: The Effect of Antithyroid Treatment.
Topics: Adult; Antithyroid Agents; Blood Glucose; Case-Control Studies; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Hyperthyroidism; Incretins; Insulin; Male; Middle Aged | 2017 |
Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.
Topics: Adiposity; Animals; Diet, High-Fat; Dyslipidemias; Eating; Fatty Liver; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Male; Mice; Mice, Inbred C57BL; Obesity; Sex Factors | 2017 |
Development of a UHPLC-MS/MS (SRM) method for the quantitation of endogenous glucagon and dosed GLP-1 from human plasma.
Topics: Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Limit of Detection; Tandem Mass Spectrometry | 2017 |
Dapagliflozin modulates glucagon secretion in an SGLT2-independent manner in murine alpha cells.
Topics: Animals; Benzhydryl Compounds; Cell Line; Cells, Cultured; Gene Silencing; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Glucosides; Humans; Mice; Signal Processing, Computer-Assisted; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Somatostatin | 2017 |
Glucagon receptor knockout mice are protected against acute olanzapine-induced hyperglycemia.
Topics: Animals; Benzodiazepines; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose Tolerance Test; Homeostasis; Hyperglycemia; Insulin; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Olanzapine; Receptors, Glucagon | 2017 |
Postprandial Suppression of Glucagon Secretion: A Puzzlement.
Topics: Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Postprandial Period | 2017 |
The role of somatostatin in GLP-1-induced inhibition of glucagon secretion in mice.
Topics: Animals; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Hypoglycemia; Mice; Mice, Inbred C57BL; Pancreas; Receptors, Somatostatin; Somatostatin | 2017 |
Increased Incretin But Not Insulin Response after Oral versus Intravenous Branched Chain Amino Acids.
Topics: Administration, Intravenous; Administration, Oral; Adult; Amino Acids, Branched-Chain; Blood Glucose; C-Peptide; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Isoleucine; Leucine; Male; Valine; Young Adult | 2017 |
Single-Molecule Combinatorial Therapeutics for Treating Obesity and Diabetes.
Topics: Brain; Diabetes Mellitus; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Obesity; Precision Medicine | 2017 |
Metabolic and neuroprotective effects of dapagliflozin and liraglutide in diabetic mice.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucosides; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Interleukin-6; Liraglutide; Male; Mice; Neurons; Neuroprotective Agents | 2017 |
Species-Dependent Mechanisms Regulating Glucose-Dependent GLP-1 Secretion?
Topics: Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Peptide Fragments | 2017 |
A novel glucagon-like peptide-1/glucagon receptor dual agonist exhibits weight-lowering and diabetes-protective effects.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; HEK293 Cells; Humans; Hyperglycemia; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Obese; Receptors, Glucagon | 2017 |
Comparative effects of intraduodenal fat and glucose on the gut-incretin axis in healthy males.
Topics: Adult; Blood Glucose; Duodenum; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucose; Healthy Volunteers; Humans; Incretins; Insulin; Insulin Secretion; Intestine, Small; Male; Postprandial Period | 2017 |
Differential Effects of Linagliptin on the Function of Human Islets Isolated from Non-diabetic and Diabetic Donors.
Topics: Cells, Cultured; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Humans; Hypoglycemic Agents; Insulin Secretion; Insulin-Secreting Cells; Linagliptin | 2017 |
Rebirth of the Incretin Concept: Its conception and early development.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hyperglycemia; Incretins; Insulin; Peptide Fragments | 2018 |
Roles of increased glycaemic variability, GLP-1 and glucagon in hypoglycaemia after Roux-en-Y gastric bypass.
Topics: Blood Glucose; Cohort Studies; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diet, Diabetic; Diet, Reducing; Female; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemia; Insulin; Insulin Secretion; London; Male; Middle Aged; Monitoring, Ambulatory; Obesity; Postoperative Complications; Postprandial Period; Prevalence; Risk Factors | 2017 |
Incretins and Their Endocrine and Metabolic Functions.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Gastrointestinal Tract; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Glucose; Humans; Hypoglycemic Agents; Incretins; Insulin; Insulin Secretion; Insulin-Secreting Cells | 2017 |
Balanced Coagonist of GLP-1 and Glucagon Receptors Corrects Dyslipidemia by Improving FGF21 Sensitivity in Hamster Model.
Topics: Adipose Tissue; Aminoisobutyric Acids; Animals; Bile; Cholesterol; Cricetinae; Diet, High-Fat; Dipeptides; Disease Models, Animal; Fibroblast Growth Factors; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Hyperlipidemias; Lipolysis; Liver; Male; Peptide Fragments; Polyethylene Glycols; Receptors, Fibroblast Growth Factor; Receptors, Glucagon; Triglycerides | 2017 |
Surgery: Postprandial hypoglycaemia following bariatric surgery.
Topics: Bariatric Surgery; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemia | 2017 |
Effects of three major amino acids found in Japanese broth on glucose metabolism and gastric emptying.
Topics: Adult; Amino Acids; Animals; Aspartic Acid; Blood Glucose; C-Peptide; Cross-Over Studies; Diet; Female; Fishes; Food, Preserved; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glutamic Acid; Histidine; Humans; Insulin; Japan; Kelp; Male; Oryza | 2018 |
Neuroprotective effects of a triple GLP-1/GIP/glucagon receptor agonist in the APP/PS1 transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hippocampus; Memory Disorders; Mice; Mice, Transgenic; Neuroprotective Agents; Plaque, Amyloid; Presenilin-1; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 2018 |
Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity.
Topics: Animals; Blood Glucose; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose Tolerance Test; Homeostasis; Insulin; Insulin Resistance; Mice; Mice, Transgenic; Neurons; Proglucagon; Receptors, Glucagon | 2017 |
Measurement of Gastrointestinal Hormones.
Topics: Bariatric Surgery; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Mass Spectrometry; Neuropeptides; Obesity; Oxyntomodulin; Specimen Handling | 2017 |
Metabolic regulation of GLP-1 and PC1/3 in pancreatic α-cell line.
Topics: Cell Line; Cell Survival; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Humans; Interleukin-6; Models, Biological; Proprotein Convertase 1; Proprotein Convertase 2; Reactive Oxygen Species | 2017 |
Enteroendocrine and adipokine associations with type 2 diabetes: Phenotypic risk scoring approaches.
Topics: Adipokines; Adolescent; Adult; Aged; Body Mass Index; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Metabolic Syndrome; Middle Aged; Phenotype; Risk Assessment; Young Adult | 2018 |
Cell-specific resetting of mouse islet cellular clocks by glucagon, glucagon-like peptide 1 and somatostatin.
Topics: Animals; Circadian Clocks; Glucagon; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Transgenic; Somatostatin | 2018 |
Central administration of coagonist of GLP-1 and glucagon receptors improves dyslipidemia.
Topics: Animals; Cholesterol; Dyslipidemias; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Homeostasis; Lipid Metabolism; Liver; Male; Mesocricetus; Obesity; Receptors, Glucagon; Signal Transduction; Triglycerides | 2018 |
Coagonist of GLP-1 and glucagon decreases liver inflammation and atherosclerosis in dyslipidemic condition.
Topics: Animals; Atherosclerosis; Cholesterol; Cricetinae; Dyslipidemias; Glucagon; Glucagon-Like Peptide 1; Inflammation; Lipid Metabolism; Liver; Male; Mice; Mice, Transgenic; Receptors, Glucagon | 2018 |
Topics: Adult; Aged; Alleles; Blood Glucose; Diabetes Mellitus, Type 2; Female; Genotyping Techniques; Glipizide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Incretins; Male; Metformin; Middle Aged; Polymorphism, Single Nucleotide; Prospective Studies; Retrospective Studies; Risk Factors; Sulfonylurea Compounds; Transcription Factor 7-Like 2 Protein | 2018 |
Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates nonalcoholic fatty liver disease.
Topics: Animals; Exenatide; Glucagon; Glucagon-Like Peptide 1; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Peptides; Receptors, Glucagon; Venoms | 2018 |
Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism.
Topics: Animals; Diabetes Mellitus, Experimental; Endosomes; Fluorescent Antibody Technique, Direct; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Islets of Langerhans; Male; Protein Binding; Protein Transport; Rats | 2018 |
Roux-en-Y gastric bypass compared with equivalent diet restriction: Mechanistic insights into diabetes remission.
Topics: Blood Glucose; Caloric Restriction; Diabetes Mellitus, Type 2; Fasting; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Liver; Male; Middle Aged; Obesity; Peptide YY; Postprandial Period; Remission Induction | 2018 |
Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses.
Topics: Aged; Cohort Studies; Denmark; ERG1 Potassium Channel; Fasting; Female; Gain of Function Mutation; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; Incretins; Long QT Syndrome; Male; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Factors | 2018 |
Gastrectomy with Roux-en-Y reconstruction as a lean model of bariatric surgery.
Topics: Adult; Bariatric Surgery; Blood Glucose; Case-Control Studies; Female; Gastrectomy; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Male; Peptide YY; Proglucagon; Thinness | 2018 |
Immune and metabolic alterations in first episode psychosis (FEP) patients.
Topics: Adult; Antipsychotic Agents; Biomarkers; Chemokine CCL4; Chemokines; Cytokines; Female; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Interleukin-17; Interleukin-6; Leptin; Male; Plasminogen Activator Inhibitor 1; Psychotic Disorders; Vascular Endothelial Growth Factor A; Young Adult | 2018 |
Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet.
Topics: Animals; Blood Glucose; Diet, High-Fat; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Incretins; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice; Mice, Knockout; Pancreas; Sodium-Glucose Transporter 1 | 2018 |
GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr
Topics: Animals; Bile Acids and Salts; Blood Glucose; Body Weight; Diet, High-Fat; Gastrectomy; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptide-2 Receptor; Glucose; Glucose Tolerance Test; Homeostasis; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Proglucagon; Receptors, G-Protein-Coupled; Receptors, Glucagon; Signal Transduction; Weight Loss | 2018 |
Agonism of receptors in the gut-pancreas axis in type 2 diabetes: are two better than one?
Topics: Diabetes Mellitus, Type 2; Double-Blind Method; Glucagon; Glucagon-Like Peptide 1; Humans; Obesity; Overweight; Peptides; Receptors, Glucagon | 2018 |
Effects of starvation and short-term refeeding on gastric emptying and postprandial blood glucose regulation in adolescent girls with anorexia nervosa.
Topics: 3-O-Methylglucose; Adolescent; Anorexia Nervosa; Blood Glucose; Breath Tests; C-Peptide; Caprylates; Carbon Isotopes; Case-Control Studies; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Postprandial Period; Starvation; Young Adult | 2018 |
Acute administration of interleukin-6 does not increase secretion of glucagon-like peptide-1 in mice.
Topics: Animals; Cell Line; Female; Glucagon; Glucagon-Like Peptide 1; Insulin Secretion; Interleukin-6; Intestine, Small; Mice; Mice, Inbred C57BL; Pancreas | 2018 |
Insulin regulates glucagon-like peptide-1 secretion by pancreatic alpha cells.
Topics: Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Humans; Insulin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Secretory Pathway | 2018 |
Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose Tolerance in Man: Lack of Correlation with β Cell Function.
Topics: Administration, Intravenous; Arginine; Biomarkers; Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Eating; Enteroendocrine Cells; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin-Secreting Cells; Peptide YY; Postprandial Period; Prediabetic State; Time Factors; United States | 2018 |
Contribution of systemic inflammation to permanence of K
Topics: Animals; Blood Glucose; Cytokines; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glyburide; Inflammation; Insulin; Insulin Resistance; Leptin; Mice; Mice, Transgenic; Mutation; Potassium Channels, Inwardly Rectifying | 2018 |
Insulin Secretion Depends on Intra-islet Glucagon Signaling.
Topics: Animals; Chlorocebus aethiops; COS Cells; Cyclic AMP; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin Secretion; Islets of Langerhans; Mice, Inbred C57BL; Perfusion; Signal Transduction | 2018 |
SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Canagliflozin; Diabetes Mellitus; Diet, High-Fat; Disease Models, Animal; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Glucosides; Glycosuria; Hypoglycemic Agents; Insulin; Male; Mice; Mice, Inbred C57BL; Sodium-Glucose Transporter 1; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2019 |
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones.
Topics: Amino Acids, Aromatic; Animals; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Glucose; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Obese; Rats; Rats, Zucker; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptors, G-Protein-Coupled; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Tryptophan | 2019 |
Chronic Exposure to Palmitate Impairs Insulin Signaling in an Intestinal L-cell Line: A Possible Shift from GLP-1 to Glucagon Production.
Topics: Cell Line; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin Resistance; Palmitates; Proprotein Convertase 2; Signal Transduction | 2018 |
Gut Hormone Responses to Mixed Meal Test in New-Onset Prediabetes/Diabetes After Acute Pancreatitis.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Magnetic Resonance Imaging; Male; Meals; Middle Aged; Oxyntomodulin; Pancreatitis; Peptide YY; Postprandial Period; Prediabetic State; Subcutaneous Fat | 2019 |
Glucagon-Like Peptide 1 in the Brain: Where Is It Coming From, Where Is It Going?
Topics: Glucagon; Glucagon-Like Peptide 1; Neurons; Proglucagon; Solitary Nucleus | 2019 |
Inappropriate glucagon and GLP-1 secretion in individuals with long-standing type 1 diabetes: effects of residual C-peptide.
Topics: Adult; Area Under Curve; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin-Secreting Cells; Male; Young Adult | 2019 |
Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis | 2019 |
Bile Modulates Secretion of Incretins and Insulin: A Study of Human Extrahepatic Cholestasis.
Topics: Ampulla of Vater; Bariatric Surgery; Bile; Bile Acids and Salts; Bilirubin; Blood Glucose; Cholestasis, Extrahepatic; Diabetes Mellitus, Type 2; Duodenal Neoplasms; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Secretion; Male; Middle Aged; Pancreaticoduodenectomy; Postprandial Period | 2019 |
Glucose-dependent Insulinotropic Polypeptide (GIP) Resistance and β-cell Dysfunction Contribute to Hyperglycaemia in Acromegaly.
Topics: Acromegaly; Adult; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Clamp Technique; Humans; Hyperglycemia; Incretins; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Prospective Studies; Receptors, Gastrointestinal Hormone | 2019 |
Investigating Intestinal Glucagon After Roux-en-Y Gastric Bypass Surgery.
Topics: Adolescent; Adult; Balloon Enteroscopy; Biomarkers; Blood Glucose; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Insulin; Intestines; Male; Meals; Middle Aged; Obesity, Morbid; Postprandial Period; Prognosis; Prospective Studies; Young Adult | 2019 |
Relationships between Body Composition and Plasma Levels of Pancreatic, Gut, and Adipose Tissue Hormones in db/db Mice, a Model of Type 2 Diabetes Mellitus.
Topics: Adipose Tissue; Animals; Body Composition; Diabetes Mellitus, Type 2; Gastrointestinal Hormones; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Leptin; Male; Mice; Mice, Inbred NOD; Pancreatic Hormones; Plasminogen Activators; Resistin | 2019 |
A novel epigenetic mechanism of FXR inhibiting GLP-1 secretion via miR-33 and its downstream targets.
Topics: 3' Untranslated Regions; Animals; Base Sequence; Cell Line; Cyclic AMP Response Element-Binding Protein; Epigenesis, Genetic; Glucagon; Glucagon-Like Peptide 1; Mice; MicroRNAs; Receptors, Cytoplasmic and Nuclear; Transcription, Genetic | 2019 |
The possible synergistic action of sex hormones and glucagon-like peptide-1 (GLP-1) agonists on body mass decline in patients with type 2 diabetes mellitus.
Topics: Adiposity; Anti-Obesity Agents; Appetite Depressants; Diabetes Mellitus, Type 2; Drug Synergism; Estradiol; Female; Glucagon; Glucagon-Like Peptide 1; Gonadal Steroid Hormones; Humans; Hypoglycemic Agents; Insulin; Male; Menstrual Cycle; Models, Biological; Overweight; Pancreas; Risk Factors; Secretory Rate; Testosterone; Weight Loss | 2019 |
Topics: Amidohydrolases; Amino Acid Substitution; Animals; Blood Glucose; Disease Models, Animal; Eating; Ethanolamines; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Injections, Intravenous; Insulin; Islets of Langerhans; Male; Metabolic Syndrome; Mice; Mice, Transgenic; Middle Aged; Oleic Acids; Postprandial Period; Receptors, G-Protein-Coupled; Taurine | 2019 |
Childhood trauma and glucose metabolism in patients with first-episode psychosis.
Topics: Adult; Adverse Childhood Experiences; Antipsychotic Agents; Biomarkers; C-Peptide; Female; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Insulin Resistance; Leptin; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Plasminogen Activator Inhibitor 1; Psychotic Disorders; Resistin | 2020 |
Comparative analysis of enteroendocrine cells and their hormones between mouse intestinal organoids and native tissues.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cells, Cultured; Cholecystokinin; Duodenum; Enteroendocrine Cells; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Green Fluorescent Proteins; Ileum; Jejunum; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Organoids; RNA, Messenger; Secretin; Signal Transduction; Transcriptome | 2020 |
Engineering Xaa-Pro dipeptidyl aminopeptidase for specific cleavage of glucagon and glucagon-like peptide 1 from fusion proteins.
Topics: Amino Acid Substitution; Bacterial Proteins; Cloning, Molecular; Dipeptidases; Enzyme Assays; Escherichia coli; Gene Expression; Genetic Vectors; Glucagon; Glucagon-Like Peptide 1; Humans; Kinetics; Lactococcus lactis; Mutagenesis, Site-Directed; Protein Engineering; Proteolysis; Recombinant Proteins | 2020 |
Incretin hormones, insulin, glucagon and advanced glycation end products in relation to cognitive function in older people with and without diabetes, a population-based study.
Topics: Aged; Blood Glucose; Case-Control Studies; Cognition; Cross-Sectional Studies; Diabetes Mellitus; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycation End Products, Advanced; Humans; Insulin; Insulin Resistance; Male; Mental Status and Dementia Tests; Optical Imaging; Sweden | 2020 |
Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion.
Topics: Animals; Blood Glucose; Colon; Enteroendocrine Cells; Female; Gene Expression; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-2 Receptor; Glucose; Insulin; Intestine, Small; Male; Metformin; Mice; Mice, Knockout; Proglucagon | 2020 |
Glucagon from the phylogenetically ancient paddlefish provides a template for the design of a long-acting peptide with effective anti-diabetic and anti-obesity activities.
Topics: Amino Acid Sequence; Animals; Anti-Obesity Agents; Apoptosis; Blood Glucose; Body Weight; Cell Proliferation; Cytokines; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Transporter Type 2; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice; Neoplasm Proteins; Obesity; Receptors, Glucagon; Structure-Activity Relationship | 2020 |
Receptor-Mediated Bioassay Reflects Dynamic Change of Glucose-Dependent Insulinotropic Polypeptide by Dipeptidyl Peptidase 4 Inhibitor Treatment in Subjects With Type 2 Diabetes.
Topics: Aged; Biological Assay; Biomarkers; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Follow-Up Studies; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Male; Prognosis; Receptors, Gastrointestinal Hormone | 2020 |
Human islets contain a subpopulation of glucagon-like peptide-1 secreting α cells that is increased in type 2 diabetes.
Topics: Animals; Biomarkers; Diabetes Mellitus, Type 2; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Humans; Immunophenotyping; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Mice | 2020 |
Alterations in pancreatic islet cell function in response to small bowel resection.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin-Secreting Cells; Intestines; Islets of Langerhans; Mice, Inbred C57BL; Pancreas; Pancreas, Exocrine | 2020 |
Mof regulates glucose level via altering different α-cell subset mass and intra-islet glucagon-like peptide-1, glucagon secretion.
Topics: Animals; Blood Glucose; Cell Line; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Histone Acetyltransferases; Homeostasis; Insulin; Islets of Langerhans; Mice; Proprotein Convertase 1; Proprotein Convertase 2 | 2020 |
Combination of Lorcaserin and GLP-1/glucagon Coagonist Improves Metabolic Dysfunction in Diet Induced-obese Mice.
Topics: Animals; Benzazepines; Body Weight; Diet, High-Fat; Energy Metabolism; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Liver; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Receptors, Glucagon; Weight Loss | 2020 |
A Protein/Lipid Preload Attenuates Glucose-Induced Endothelial Dysfunction in Individuals with Abnormal Glucose Tolerance.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 2; Dietary Fats; Dietary Proteins; Endothelium, Vascular; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Glucose Tolerance Test; Humans; Hyperglycemia; Insulin; Male; Middle Aged; Postprandial Period; Young Adult | 2020 |
Dapagliflozin promotes beta cell regeneration by inducing pancreatic endocrine cell phenotype conversion in type 2 diabetic mice.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; C-Peptide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Endocrine Cells; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Glucose; Glucosides; Insulin; Insulin-Secreting Cells; Male; Mice; Proprotein Convertase 1; Regeneration; Sodium-Glucose Transporter 2 Inhibitors | 2020 |
The GPR40 Full Agonist SCO-267 Improves Liver Parameters in a Mouse Model of Nonalcoholic Fatty Liver Disease without Affecting Glucose or Body Weight.
Topics: Administration, Oral; Animals; Body Weight; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Liver; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Receptors, G-Protein-Coupled; Triglycerides | 2020 |
Glucagon-like peptide-1 receptor agonists and the appropriate measurement of gastric emptying.
Topics: Blood Glucose; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Peptide Fragments | 2020 |
Protein restriction during pregnancy impairs intra-islet GLP-1 and the expansion of β-cell mass.
Topics: Animals; Diet, Protein-Restricted; Down-Regulation; Female; Gene Expression Regulation; Gene Regulatory Networks; Glucagon; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Islets of Langerhans; Pregnancy; Proprotein Convertase 2; Rats | 2020 |
Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice.
Topics: Animals; Diabetic Neuropathies; Disease Models, Animal; Ganglia, Spinal; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Fibers, Myelinated; Neural Conduction; Neuronal Outgrowth; Receptors, Glucagon; RNA, Messenger | 2020 |
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Glucosides; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Mice; Pancreas; Rats; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors | 2020 |
The triterpenoid sapogenin (2α-OH-Protopanoxadiol) ameliorates metabolic syndrome via the intestinal FXR/GLP-1 axis through gut microbiota remodelling.
Topics: Animals; Diet, High-Fat; Drug Design; Gastrointestinal Microbiome; Glucagon; Glucagon-Like Peptide 1; Gynostemma; Intestines; Male; Metabolic Syndrome; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Plant Extracts; RNA-Binding Proteins; RNA, Ribosomal, 16S; Taurocholic Acid | 2020 |
Hypoglycemia in cystic fibrosis during an extended oral glucose tolerance test.
Topics: Adolescent; Adult; Blood Glucose; Cystic Fibrosis; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Intolerance; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Male; Young Adult | 2020 |
Immunohistochemical study on the expression of biologically active substances in the endocrine pancreas of the European bison.
Topics: Animals; Bison; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Immunohistochemistry; Insulin; Male; Pancreas; Somatostatin | 2020 |
Dipeptidyl peptidase-4 activity, lipopolysaccharide, C-reactive protein, glucose metabolism, and gut peptides 3 months after bariatric surgery.
Topics: Bariatric Surgery; Blood Glucose; C-Reactive Protein; Dipeptidyl Peptidase 4; Gastric Bypass; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Lipopolysaccharides | 2021 |
Maternal transfer of environmentally relevant polybrominated diphenyl ethers (PBDEs) produces a diabetic phenotype and disrupts glucoregulatory hormones and hepatic endocannabinoids in adult mouse female offspring.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Endocannabinoids; Female; Glucagon; Glucagon-Like Peptide 1; Halogenated Diphenyl Ethers; Hormones; Insulin; Liver; Male; Mice; Mice, Inbred C57BL; Pregnancy; Prenatal Exposure Delayed Effects | 2020 |
Expected values for gastrointestinal and pancreatic hormone concentrations in healthy volunteers in the fasting and postprandial state.
Topics: Adolescent; Adult; Aged; Blood Glucose; Fasting; Female; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Healthy Volunteers; Humans; Insulin; Male; Middle Aged; Obesity; Pancreatic Hormones; Peptide YY; Postprandial Period; Reference Values; Young Adult | 2021 |
Elevated Serum Amino Acids Induce a Subpopulation of Alpha Cells to Initiate Pancreatic Neuroendocrine Tumor Formation.
Topics: Adenoma, Islet Cell; Amino Acids; Animals; Blood Glucose; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Glucose; Humans; Insulin; Insulin-Secreting Cells; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Neuroendocrine Tumors; Pancreatic Neoplasms; Receptors, Glucagon; Signal Transduction | 2020 |
Glucagon Resistance and Decreased Susceptibility to Diabetes in a Model of Chronic Hyperglucagonemia.
Topics: Animals; Blood Glucose; Body Weight; Disease Models, Animal; Disease Susceptibility; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose Intolerance; Insulin; Insulin Secretion; Mechanistic Target of Rapamycin Complex 1; Mice; Receptors, Glucagon; Signal Transduction; Tuberous Sclerosis Complex 2 Protein | 2021 |
Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely rapid degradation but marked variation between available assays.
Topics: Animals; Blood Glucose; Dipeptidyl Peptidase 4; Dipeptidyl-Peptidase IV Inhibitors; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemia; Hypoglycemic Agents; Mice; Peptide Fragments; Proteolysis; Receptors, Gastrointestinal Hormone | 2021 |
Incretins in fibrocalculous pancreatic diabetes: A unique subtype of pancreatogenic diabetes.
Topics: Adolescent; Adult; Biomarkers; Blood Glucose; C-Peptide; Calcinosis; Case-Control Studies; Diabetes Mellitus, Type 2; Dipeptidyl Peptidase 4; Female; Fibrosis; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Incretins; Insulin; Male; Middle Aged; Pancreatitis, Chronic; Time Factors; Young Adult | 2021 |
Salivary concentrations of cytokines and other analytes in healthy children.
Topics: Adiponectin; Age Factors; Body Height; C-Peptide; Child; Cytokines; Female; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Interleukin-13; Interleukin-2; Leptin; Male; Multivariate Analysis; Nicotinamide Phosphoribosyltransferase; Reference Values; Saliva | 2021 |
GLP-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice.
Topics: Animals; Diet, High-Fat; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Male; Mice, Inbred C57BL; Signal Transduction | 2021 |
S3-2, a novel long-lasting oxyntomodulin derivative, exerts improvement on diabesity and renal injury through activating GLP-1 and glucagon receptors.
Topics: Albumins; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Hypoglycemic Agents; Insulin; Kidney; Male; Mice; Mice, Inbred C57BL; Obesity; Oxyntomodulin; Peptides; Receptors, Glucagon | 2021 |
Evidence for Glucagon Secretion and Function Within the Human Gut.
Topics: Adult; Aged; Aged, 80 and over; Cholesterol; Cohort Studies; Female; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Intestinal Mucosa; Male; Middle Aged | 2021 |
Role of zonulin and GLP-1/DPP-IV in alleviation of diabetes mellitus by peptide/polypeptide fraction of Aloe vera in streptozotocin- induced diabetic wistar rats.
Topics: Aloe; Animals; Blood Glucose; Cell Survival; Cytokines; Diabetes Mellitus, Experimental; Dipeptidyl Peptidase 4; Glucagon; Glucagon-Like Peptide 1; Glucose-6-Phosphate; Glycogen; Haptoglobins; Hexokinase; Hypoglycemic Agents; Inflammation; Insulin; Intestine, Small; Liver; Nitric Oxide; Pancreas; Plant Extracts; Protein Precursors; Rats, Wistar; Streptozocin | 2021 |
Glucagon-Producing Cell Expansion in Wistar Rats. Changes to Islet Architecture After Sleeve Gastrectomy.
Topics: Animals; Blood Glucose; Gastrectomy; Glucagon; Glucagon-Like Peptide 1; Insulin; Jejunum; Obesity, Morbid; Rats; Rats, Wistar | 2021 |
Glucagon Shows Higher Sensitivity than Insulin to Grapeseed Proanthocyanidin Extract (GSPE) Treatment in Cafeteria-Fed Rats.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Grape Seed Extract; Insulin; Islets of Langerhans; Proanthocyanidins; Rats; Rats, Wistar | 2021 |
Novel mouse model expands potential human α-cell research.
Topics: Animals; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Islets of Langerhans; Mice | 2021 |
Acute pancreatitis-induced islet dysfunction in ferrets.
Topics: Acute Disease; Amylases; Animals; Blood Glucose; Ceruletide; Ferrets; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hyperglycemia; Insulin; Insulin Resistance; Interleukin-6; Lipase; Pancreatitis; Tumor Necrosis Factor-alpha | 2021 |
Mutational Landscape of the Proglucagon-Derived Peptides.
Topics: Amino Acid Sequence; Datasets as Topic; DNA Mutational Analysis; Gene Frequency; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Models, Molecular; Mutation, Missense; Pharmacogenomic Testing; Proglucagon; Protein Precursors; Protein Structure, Secondary | 2021 |
Transient antibiotic-induced changes in the neonatal swine intestinal microbiota impact islet expression profiles reducing subsequent function.
Topics: Animals; Anti-Bacterial Agents; Gastrointestinal Microbiome; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Swine | 2021 |
Whey protein preload enhances the active GLP-1 response and reduces circulating glucose in women with polycystic ovarian syndrome.
Topics: Adolescent; Adult; Analysis of Variance; Area Under Curve; Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Dietary Proteins; Dietary Supplements; Female; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Hyperglycemia; Incretins; Insulin; Polycystic Ovary Syndrome; Postprandial Period; Whey Proteins; Young Adult | 2021 |
A method for constructing GLP-1 overexpression intestinal organoids.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Insulin; Mice; Organoids | 2021 |
Variation in the Evolution and Sequences of Proglucagon and the Receptors for Proglucagon-Derived Peptides in Mammals.
Topics: Amino Acid Sequence; Animals; Evolution, Molecular; Genetic Variation; Genome; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptide-2 Receptor; Mammals; Phylogeny; Proglucagon; Receptors, Glucagon | 2021 |
The sugar-responsive enteroendocrine neuropeptide F regulates lipid metabolism through glucagon-like and insulin-like hormones in Drosophila melanogaster.
Topics: Animals; Animals, Genetically Modified; Drosophila melanogaster; Enteroendocrine Cells; Female; Glucagon; Glucagon-Like Peptide 1; Hormones; Humans; Hypoglycemia; Incretins; Insulin; Insulin Secretion; Lipid Metabolism; Mutation; Neuropeptides; Receptors, Neuropeptide; Sugars | 2021 |
[Gly²]-GLP-2, But Not Glucagon or [D-Ala²]-GLP-1, Controls Collagen Crosslinking in Murine Osteoblast Cultures.
Topics: Animals; Cells, Cultured; CHO Cells; Collagen; Cricetulus; Gastrointestinal Hormones; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-2 Receptor; Mice; Osteoblasts; Protein Multimerization | 2021 |
The Human and Mouse Islet Peptidome: Effects of Obesity and Type 2 Diabetes, and Assessment of Intraislet Production of Glucagon-like Peptide-1.
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Islets of Langerhans; Mice; Obesity | 2021 |
Entero-Pancreatic Hormone Secretion, Gastric Emptying, and Glucose Absorption After Frequently Sampled Meal Tests.
Topics: Adult; Biomarkers; C-Peptide; Cholecystokinin; Follow-Up Studies; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Insulin; Male; Meals; Pancreatic Hormones; Prognosis; Prospective Studies; Young Adult | 2022 |
Antiobesity therapeutics with complementary dual-agonist activities at glucagon and glucagon-like peptide 1 receptors.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Mice; Receptors, Glucagon; Thermogenesis | 2022 |
A conversation with Dan Drucker.
Topics: Animals; Dipeptidyl-Peptidase IV Inhibitors; Endocrinology; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; History, 20th Century; History, 21st Century; Humans; Ontario; Patents as Topic | 2021 |
Glucagon Potentiates Insulin Secretion Via β-Cell GCGR at Physiological Concentrations of Glucose.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose Intolerance; Insulin; Insulin Secretion; Insulin-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Glucagon; Signal Transduction | 2021 |
Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release.
Topics: Animals; Colorectal Neoplasms; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin Secretion; Lysophospholipids; Male; Mice; Mice, Inbred ICR; Panax; Plant Extracts; Receptors, Lysophosphatidic Acid; Signal Transduction; Tumor Cells, Cultured | 2021 |
Impact of the different biliopancreatic limb length on diabetes and incretin hormone secretion following distal gastrectomy in gastric cancer patients.
Topics: Aged; Anastomosis, Roux-en-Y; Blood Glucose; Body Mass Index; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gastrectomy; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Incretins; Insulin; Male; Middle Aged; Postoperative Period; Prospective Studies; Stomach Neoplasms; Treatment Outcome | 2021 |
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation.
Topics: Animals; Appetite; Appetite Depressants; Blood Glucose; Cholecystokinin; Exenatide; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hypoglycemic Agents; Insulin; Liraglutide; Male; Mice; Mice, Inbred C57BL; Neurons; Receptors, Gastrointestinal Hormone | 2022 |
A novel integrated QSP model of in vivo human glucose regulation to support the development of a glucagon/GLP-1 dual agonist.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin | 2022 |
Intra-islet glucagon confers β-cell glucose competence for first-phase insulin secretion and favors GLP-1R stimulation by exogenous glucagon.
Topics: Animals; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred C57BL; Rats | 2022 |
Pancreatic and gut hormone responses to mixed meal test in post-chronic pancreatitis diabetes mellitus.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Pancreatitis, Chronic; Peptide YY | 2022 |
GLP-1/GIP/glucagon receptor triagonism gets its try in humans.
Topics: Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 2022 |
Effects of luseogliflozin on the secretion of islet hormones and incretins in patients with type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemic Agents; Incretins; Sorbitol | 2022 |
The Essential Role of Pancreatic α-Cells in Maternal Metabolic Adaptation to Pregnancy.
Topics: Animals; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Glucose; Insulin; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Knockout; Pregnancy; Receptors, Glucagon | 2022 |
Pancreatic cancer-associated diabetes mellitus is characterized by reduced β-cell secretory capacity, rather than insulin resistance.
Topics: Aged; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin Resistance; Pancreatic Neoplasms | 2022 |
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Topics: Cryoelectron Microscopy; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Peptides; Receptors, G-Protein-Coupled; Receptors, Glucagon | 2022 |
Preclinical evaluation of a protracted GLP-1/glucagon receptor co-agonist: Translational difficulties and pitfalls.
Topics: Animals; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Mice; Mice, Obese; Obesity; Rats; Receptors, Glucagon; Weight Loss | 2022 |
High Protein Diet Feeding Aggravates Hyperaminoacidemia in Mice Deficient in Proglucagon-Derived Peptides.
Topics: Animals; Diet, High-Protein; Glucagon; Glucagon-Like Peptide 1; Mice; Peptides; Proglucagon | 2022 |
The alpha-7 nicotinic acetylcholine receptor agonist GTS-21 engages the glucagon-like peptide-1 incretin hormone axis to lower levels of blood glucose in db/db mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Incretins; Insulin; Insulin Resistance; Male; Mice; Mice, Knockout; Nicotinic Agonists; Pyridines; Sitagliptin Phosphate; Tyrosine | 2022 |
Metabolic effects of combined glucagon receptor antagonism and glucagon-like peptide-1 receptor agonism in high fat fed mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diet, High-Fat; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Insulin; Mice; Receptors, Glucagon | 2022 |
Effects of ALT-801, a GLP-1 and glucagon receptor dual agonist, in a translational mouse model of non-alcoholic steatohepatitis.
Topics: Animals; Cholesterol; Collagen; Disease Models, Animal; Galectin 3; Glucagon; Glucagon-Like Peptide 1; Inflammation; Interleukin-2; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Non-alcoholic Fatty Liver Disease; Obesity; Receptors, Antigen, T-Cell; Receptors, Glucagon; Recombinant Fusion Proteins; Transaminases; Triglycerides | 2022 |
Clinical relevance of dual agonist of glucagon and glucagon-like peptide-1 receptors to achieve functional restoration of first- and second-phase insulin secretion.
Topics: Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Insulin Secretion; Peptide Fragments; Receptors, Glucagon | 2022 |
Incretin Response to Mixed Meal Challenge in Active Cushing's Disease and after Pasireotide Therapy.
Topics: Blood Glucose; C-Peptide; Diabetes Mellitus; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Incretins; Insulin; Insulin Resistance; Meals; Pituitary ACTH Hypersecretion; Somatostatin | 2022 |
Topics: Glucagon; Glucagon-Like Peptide 1; Molecular Dynamics Simulation; Peptides; Protein Domains | 2023 |
Impact of TOTUM-63, a fibre and polyphenol rich plant-based composition, on gut and pancreatic hormone secretion in diet-induced obese mice.
Topics: Animals; Blood Glucose; Body Weight; Diet, High-Fat; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Peptide YY; Plant Extracts; Polyphenols; Pyruvates; Weight Gain | 2022 |
Glucagon-like peptide-1 effect on β-cell function varies according to diabetes remission status after Roux-en-Y gastric bypass.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose Intolerance; Humans; Insulin; Retrospective Studies | 2022 |
The effect of capromorelin on glycemic control in healthy dogs.
Topics: Animals; Blood Glucose; Blood Glucose Self-Monitoring; Cats; Dogs; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycemic Control; Insulin; Piperidines; Prospective Studies; Pyrazoles | 2022 |
Next generation GLP-1/GIP/glucagon triple agonists normalize body weight in obese mice.
Topics: Animals; Body Weight; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Mice; Mice, Obese; Peptides; Receptors, Glucagon | 2022 |
Disrupted and Elevated Circadian Secretion of Glucagon-Like Peptide-1 in a Murine Model of Type 2 Diabetes.
Topics: Animals; Circadian Rhythm; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Mice | 2022 |
Glucagon-like peptide-1 receptor agonists, weight loss, and gastric emptying: have I gut news for you.
Topics: Blood Glucose; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Peptide Fragments; Weight Loss | 2022 |
Comparison of Hormonal Response to a Mixed-Meal Challenge in Hypoglycemia After Sleeve Gastrectomy vs Gastric Bypass.
Topics: Blood Glucose; Female; Gastrectomy; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hypoglycemia; Incretins; Insulin; Male; Middle Aged; Obesity, Morbid | 2022 |
Topics: Computational Biology; Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Receptors, Glucagon | 2023 |
Comparative Effects of Co-Ingesting Whey Protein and Glucose Alone and Combined on Blood Glucose, Plasma Insulin and Glucagon Concentrations in Younger and Older Men.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hyperglycemia; Insulin; Male; Postprandial Period; Whey Proteins | 2022 |
Response to "An approach to insulin tapering and discontinuation after glucagon-like peptide-1 receptor agonist initiation".
Topics: Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin | 2022 |
The Cytoskeletal Transport Protein, Secretagogin, Is Essential for Diurnal Glucagon-like Peptide-1 Secretion in Mice.
Topics: Actins; Animals; Carrier Proteins; Glucagon; Glucagon-Like Peptide 1; Glucose; Incretins; Insulin; Mice; Proteasome Endopeptidase Complex; Secretagogins | 2022 |
Identification of a Multi-Component Formulation for Intestinal Delivery of a GLP-1/Glucagon Co-agonist Peptide.
Topics: Animals; Capsules; Citric Acid; Glucagon; Glucagon-Like Peptide 1; Intestinal Absorption; Peptide Hydrolases; Peptides; Protease Inhibitors; Rats; Swine; Swine, Miniature | 2022 |
Alpha-cells and therapy of diabetes: Inhibition, antagonism or death?
Topics: Animals; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Guanidines; Humans; Hypoglycemic Agents; Insulin; Metformin; Receptors, Glucagon | 2022 |
Differential effects of RYGB surgery and best medical treatment for obesity-diabetes on intestinal and islet adaptations in obese-diabetic ZDSD rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Fenofibrate; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Insulin; Liraglutide; Male; Metformin; Obesity; Ramipril; Rats; Rats, Sprague-Dawley; Rats, Zucker; Rosuvastatin Calcium; Somatostatin | 2022 |
The Levels of Ghrelin, Glucagon, Visfatin and Glp-1 Are Decreased in the Peritoneal Fluid of Women with Endometriosis along with the Increased Expression of the CD10 Protease by the Macrophages.
Topics: Ascitic Fluid; Biomarkers; C-Peptide; Dipeptidyl Peptidase 4; Endometriosis; Female; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Leptin; Macrophages; Nicotinamide Phosphoribosyltransferase; Peptide Hydrolases; Plasminogen Activator Inhibitor 1; Resistin | 2022 |
Involvement of trigeminal axons in nose-to-brain delivery of glucagon-like peptide-2 derivative.
Topics: Axons; Brain; Cell-Penetrating Peptides; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2 | 2022 |
Metabolic Dysregulation in Adult Survivors of Pediatric Hematopoietic Stem Cell Transplantation: The Role of Incretins.
Topics: Adult; Blood Glucose; Child; Cross-Sectional Studies; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Hematopoietic Stem Cell Transplantation; Humans; Incretins; Insulin; Male; Metabolic Syndrome; Survivors | 2023 |
Predictors of acarbose therapeutic efficacy in newly diagnosed type 2 diabetes mellitus patients in China.
Topics: Acarbose; Blood Glucose; China; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Insulins | 2022 |
Multi-action Secretagogin Controls Circadian Glucagon-Like Peptide-1 Secretion.
Topics: Animals; Carrier Proteins; Glucagon; Glucagon-Like Peptide 1; Incretins; Mice; Secretagogins | 2022 |
A Cre-driver rat model for anatomical and functional analysis of glucagon (Gcg)-expressing cells in the brain and periphery.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Male; Rats; RNA, Messenger; Solitary Nucleus | 2022 |
Development of a selective, sensitive and robust oxyntomodulin dual monoclonal antibody immunoassay.
Topics: Antibodies, Monoclonal; Glucagon; Glucagon-Like Peptide 1; Humans; Immunoassay; Oxyntomodulin; Proglucagon; Protein Precursors | 2022 |
The Effects of Dual GLP-1/Glucagon Receptor Agonists with Different Receptor Selectivity in Mouse Models of Obesity and Nonalcoholic Steatohepatitis.
Topics: Animals; Body Weight; Complement C4; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Lipids; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Receptors, Glucagon | 2023 |
Altered chronic glycemic control in a clinically relevant model of rat thoracic spinal contusion.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glycemic Control; Humans; Insulin; Rats | 2023 |
The Effect of Glucagon-Like Peptide 1 Receptor Blockade on Glucagon-Induced Stimulation of Insulin Secretion.
Topics: Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Insulin Secretion; Peptide Fragments | 2023 |
The 'early' postprandial glucagon response is related to the rate of gastric emptying in type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Postprandial Period | 2023 |
Circulating Dopamine Is Regulated by Dietary Glucose and Controls Glucagon-like 1 Peptide Action in White Adipose Tissue.
Topics: Adipose Tissue, White; Animals; Diet, High-Fat; Dopamine; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Rats; Rats, Wistar | 2023 |
Plasma concentrations of glucagon and glucagon-like peptide-1 are reduced in dogs with aminoaciduric canine hypoaminoacidemic hepatopathy syndrome versus healthy dogs: a preliminary study.
Topics: Animals; Blood Glucose; Case-Control Studies; Dog Diseases; Dogs; Fasting; Glucagon; Glucagon-Like Peptide 1; Insulin; Peptide Fragments; Postprandial Period; Syndrome | 2023 |
Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies.
Topics: Adipose Tissue; Aged; Endothelial Cells; Fatty Acids; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Male; Middle Aged; Receptors, G-Protein-Coupled | 2023 |
Glucagon Acting at the GLP-1 Receptor Contributes to β-Cell Regeneration Induced by Glucagon Receptor Antagonism in Diabetic Mice.
Topics: Animals; Antibodies, Monoclonal; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Insulin; Mice; Receptors, Glucagon; Regeneration | 2023 |
Implication of sugar, protein and incretins in excessive glucagon secretion in type 2 diabetes after mixed meals.
Topics: Blood Glucose; Caseins; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Insulin; Meals; Obesity; Sucrose; Sugars | 2023 |
The Insulin: Glucagon Ratio and Obesity.
Topics: Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Obesity | 2023 |
Circulating levels of gastrointestinal hormones in prediabetes reversing to normoglycemia or progressing to diabetes in a year-A cross-sectional and prospective analysis.
Topics: Blood Glucose; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Humans; Insulin; Prediabetic State | 2023 |
PYY (3-36) protects against high fat feeding induced changes of pancreatic islet and intestinal hormone content and morphometry.
Topics: Animals; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Insulin-Secreting Cells; Islets of Langerhans; Mice | 2023 |
Perspectives in weight control in diabetes - SGLT2 inhibitors and GLP-1-glucagon dual agonism.
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Sodium-Glucose Transporter 2 Inhibitors; Weight Loss | 2023 |
Is retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist a step forward in the treatment of diabetes and obesity?
Topics: Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Hypoglycemic Agents; Obesity; Receptors, Glucagon | 2023 |
Designer GLP1 poly-agonist peptides in the management of diabesity.
Topics: Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins | 2023 |
A century of glucagon.
Topics: Glucagon; Glucagon-Like Peptide 1; Humans; Peptide Fragments | 2023 |
Salivary Hormones Leptin, Ghrelin, Glucagon, and Glucagon-Like Peptide 1 and Their Relation to Sweet Taste Perception in Diabetic Patients.
Topics: Diabetes Mellitus; Ghrelin; Glucagon; Glucagon-Like Peptide 1; Humans; Leptin; Taste; Taste Perception; Transcription Factors | 2023 |
Brief overview: glucagon history and physiology.
Topics: Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Glucose; Insulin; Islets of Langerhans | 2023 |
Circulating levels of proglucagon-derived peptides are differentially regulated by the glucagon-like peptide-1 agonist liraglutide and the centrally acting naltrexone/bupropion and can predict future weight loss and metabolic improvements: A 6-month long
Topics: Bupropion; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Liraglutide; Naltrexone; Obesity; Overweight; Peptides; Proglucagon; Weight Loss | 2023 |
The novel GIP, GLP-1 and glucagon receptor agonist retatrutide delays gastric emptying.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin; Receptors, Glucagon | 2023 |
Computational Peptide Design Cotargeting Glucagon and Glucagon-like Peptide-1 Receptors.
Topics: Diabetes Mellitus; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Obesity; Peptides; Receptors, Glucagon | 2023 |
Self-assembled GLP-1/glucagon peptide nanofibrils prolong inhibition of food intake.
Topics: Animals; Eating; Glucagon; Glucagon-Like Peptide 1; Oxyntomodulin; Peptide Hydrolases; Peptides; Receptors, Glucagon | 2023 |
Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes.
Topics: Adult; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Incretins; Infant, Newborn; Insulin | 2023 |
GPCR Promiscuity Reshapes Islet Physiology.
Topics: Fasting; Glucagon; Glucagon-Like Peptide 1; Insulin; Proglucagon | 2023 |
Adolescents with obesity treated with exenatide maintain endogenous GLP-1, reduce DPP-4, and improve glycemic control.
Topics: Adolescent; Child; Exenatide; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucose; Glycemic Control; Humans; Insulin; Pediatric Obesity; Proinsulin | 2023 |