Page last updated: 2024-09-04

glucagon and gamma-aminobutyric acid

glucagon has been researched along with gamma-aminobutyric acid in 44 studies

Compound Research Comparison

Studies
(glucagon)
Trials
(glucagon)
Recent Studies (post-2010)
(glucagon)
Studies
(gamma-aminobutyric acid)
Trials
(gamma-aminobutyric acid)
Recent Studies (post-2010) (gamma-aminobutyric acid)
26,0391,4983,05440,2151,4239,631

Protein Interaction Comparison

ProteinTaxonomyglucagon (IC50)gamma-aminobutyric acid (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 2Rattus norvegicus (Norway rat)0.0292
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)0.0332
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)0.0323
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)2.152
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)0.0333
Sodium- and chloride-dependent GABA transporter 1Homo sapiens (human)5.2623
Sodium- and chloride-dependent taurine transporterHomo sapiens (human)354
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)2.51
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent GABA transporter 1Mus musculus (house mouse)6.349
Sodium- and chloride-dependent GABA transporter 2Mus musculus (house mouse)7.0795
Sodium- and chloride-dependent GABA transporter 3Mus musculus (house mouse)8.1283
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.02
Sodium- and chloride-dependent betaine transporterHomo sapiens (human)6.4082
Sodium- and chloride-dependent GABA transporter 3Homo sapiens (human)3.9953
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)0.0333
GABA theta subunitRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)0.0333
Gamma-aminobutyric acid type B receptor subunit 1Rattus norvegicus (Norway rat)0.0292

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199013 (29.55)18.7374
1990's11 (25.00)18.2507
2000's11 (25.00)29.6817
2010's5 (11.36)24.3611
2020's4 (9.09)2.80

Authors

AuthorsStudies
Gourley, DR1
Eldred, WD; Zhang, D1
Bertrand, G; Gilon, P; Henquin, JC; Loubatières-Mariani, MM; Remacle, C1
Lukasiewicz, P; Maguire, G; Werblin, FS; Yang, CY; Yazulla, S1
Berggren, PO; Rorsman, P; Smith, PA1
Gylfe, E1
Berggren, PO; Bokvist, K; Ericson, H; Möhler, H; Ostenson, CG; Rorsman, P; Smith, PA1
Gilon, P; Remacle, C1
Bauer, B; Ehinger, B; Tornqvist, K; Waga, J1
Yoshioka, M1
Elde, RP; Garry, DJ; Madsen, A; Maley, BE; Sorenson, RL1
Gläsener, G; Himstedt, W; Matute, C; Weiler, R1
Minuk, GY; Sarjeant, EJ1
Unger, RH1
Brecha, N; Karten, HJ1
Ishikawa, K; Shimazu, T1
Coppola, L; Frascolla, N; Giugliano, D; Passariello, N; Sgambato, S; Torella, R1
Cappelletti, G; Cavagnini, F; Dubini, A; Invitti, C; Pinto, M; Polli, EE1
Gilbert, M; Kassis, N; Ktorza, A; Laury, MC; Magnan, C; Pénicaud, L; Philippe, J1
Baldeón, ME; Beverly, JL; Gaskins, HR; Selassie, L1
McCarty, MF1
Koeslag, JH; Saunders, PT; Wessels, JA1
Fischer, AJ; Poon, J; Seltner, RL; Stell, WK1
Cooper, RL; Rastogi, KS; Shi, ZQ; Vranic, M1
Adeghate, E; Pallot, DJ; Ponery, AS; Singh, J1
De Proft, R; Dejonghe, S; Gorus, F; Ling, Z; Pipeleers, D; Schuit, F; Winnock, F1
Hayashi, M; Morimoto, R; Moriyama, Y; Muroyama, A; Otsuka, M; Uehara, S; Yamamoto, A1
Birnir, B; Braun, M; Buschard, K; Gromada, J; Rorsman, P; Salehi, A; Sewing, S; Wendt, A1
Aragón, C; Danbolt, NC; Davanger, S; Fortin, D; Frøyland, M; Gammelsaeter, R; Gundersen, V; Storm-Mathisen, J1
Buijs, RM; Kalsbeek, A; La Fleur, S; Van Heijningen, C1
Berthoud, HR; Patterson, LM; Zheng, H1
Beverly, JL; Chan, O; Lawson, M; Sherwin, RS; Zhu, W1
Bailey, SJ; Ravier, MA; Rutter, GA1
Al-Noori, S; Figlewicz, DP; Sanders, CM; Sanders, NM; Taborsky, GJ; West, C; Wilkinson, CW; Zavosh, A1
Adeghate, E; Al-Salam, S; Hameed, R; Parvez, HS1
del Rio, RM; Feldmann, N; Gjinovci, A; Tamarit-Rodriguez, J; Wiederkehr, A; Wollheim, CB1
Bennett, MJ; Chen, J; Chen, P; Daikhin, Y; Doliba, N; Li, C; Liu, C; Matschinsky, FM; Naji, A; Nissim, I; Stanley, CA; Stokes, D; Yudkoff, M; Zhang, T1
Atkinson, M; Bortell, R; Deurloo, M; Feng, ZP; Greiner, DL; Hasilo, C; Li, X; Li, Y; Liang, C; Paraskevas, S; Prud'homme, GJ; Purwana, I; Shen, E; Son, DO; Tadkase, A; Wang, Q; Zhang, Z; Zheng, J1
Davis, I; Davis, SN; Hedrington, MS; Mikeladze, M; Tate, DB; Younk, LM1
Feng, AL; Feng, Q; Gui, L; Kaltsidis, G; Lu, WY; Xiang, YY1
Huising, MO1
Charlotte Moffett, R; Flatt, PR; Irwin, N; Sarnobat, D; Tarasov, AI1
Cui, X; Gu, L; Hong, T; Lin, X; Wei, R; Yang, J; Yang, K1
Choat, HM; Lunsford, AA; Martin, A; McCormick, KL; McGwin, GG; Mick, GJ; Tse, HM1

Reviews

3 review(s) available for glucagon and gamma-aminobutyric acid

ArticleYear
Isolation and characterization of membrane drug receptors.
    Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques, 1976, Volume: 20

    Topics: Animals; Drug Tolerance; gamma-Aminobutyric Acid; Glucagon; Glycine; Humans; Insulin; Insulin Resistance; Membranes; Morphine; Receptor, Insulin; Receptors, Adrenergic, beta; Receptors, Cell Surface; Receptors, Cholinergic; Receptors, Drug; Receptors, Opioid; Sodium; Substance-Related Disorders; Toxins, Biological

1976
Localization of neuroactive substances in the vertebrate retina: evidence for lamination in the inner plexiform layer.
    Vision research, 1983, Volume: 23, Issue:10

    Topics: Acetylcholine; Animals; Birds; Dopamine; Enkephalins; gamma-Aminobutyric Acid; Glucagon; Melatonin; Nerve Tissue Proteins; Neurotensin; Neurotransmitter Agents; Retina; Serotonin; Somatostatin; Substance P; Vasoactive Intestinal Peptide

1983
Paracrine regulation of insulin secretion.
    Diabetologia, 2020, Volume: 63, Issue:10

    Topics: Acetylcholine; Autocrine Communication; Corticotropin-Releasing Hormone; gamma-Aminobutyric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Humans; Insulin Secretion; Insulin-Secreting Cells; Paracrine Communication; Serotonin; Somatostatin; Somatostatin-Secreting Cells; Urocortins

2020

Trials

4 trial(s) available for glucagon and gamma-aminobutyric acid

ArticleYear
A possible role of gamma-aminobutyric acid in the control of the endocrine pancreas.
    The Journal of clinical endocrinology and metabolism, 1982, Volume: 54, Issue:6

    Topics: Administration, Oral; Adult; Baclofen; Blood Glucose; Female; gamma-Aminobutyric Acid; Glucagon; Glucose; Growth Hormone; Humans; Insulin; Islets of Langerhans; Male; Middle Aged

1982
Effects of gamma aminobutyric acid (GABA) and muscimol on endocrine pancreatic function in man.
    Metabolism: clinical and experimental, 1982, Volume: 31, Issue:1

    Topics: Adolescent; Adult; Blood Glucose; C-Peptide; Female; gamma-Aminobutyric Acid; Glucagon; Humans; Insulin; Islets of Langerhans; Male; Middle Aged; Muscimol; Oxazoles

1982
Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine.
    The Journal of biological chemistry, 2013, Feb-08, Volume: 288, Issue:6

    Topics: Adult; Diabetes Mellitus, Type 2; Female; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Glucose; Glycine; Humans; Insulin-Secreting Cells; Male; Middle Aged; Receptors, GABA; Receptors, Glycine; Sodium Oxybate

2013
A randomized trial of oral gamma aminobutyric acid (GABA) or the combination of GABA with glutamic acid decarboxylase (GAD) on pancreatic islet endocrine function in children with newly diagnosed type 1 diabetes.
    Nature communications, 2022, 12-24, Volume: 13, Issue:1

    Topics: Animals; Diabetes Mellitus, Type 1; gamma-Aminobutyric Acid; Glucagon; Glutamate Decarboxylase; Islets of Langerhans

2022

Other Studies

37 other study(ies) available for glucagon and gamma-aminobutyric acid

ArticleYear
Colocalization of enkephalin-, glucagon-, and corticotropin-releasing factor-like immunoreactivity in GABAergic amacrine cells in turtle retina.
    Brain research, 1992, Nov-20, Volume: 596, Issue:1-2

    Topics: Animals; Corticotropin-Releasing Hormone; Enkephalins; gamma-Aminobutyric Acid; Glucagon; Immunohistochemistry; Neuropeptides; Retina; Tissue Distribution; Turtles

1992
The influence of gamma-aminobutyric acid on hormone release by the mouse and rat endocrine pancreas.
    Endocrinology, 1991, Volume: 129, Issue:5

    Topics: Animals; Female; gamma-Aminobutyric Acid; Glucagon; Glutamate Decarboxylase; Insulin; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Pancreatic Hormones; Rats; Rats, Inbred Strains; Somatostatin

1991
Amacrine cells in the tiger salamander retina: morphology, physiology, and neurotransmitter identification.
    The Journal of comparative neurology, 1991, Oct-01, Volume: 312, Issue:1

    Topics: Ambystoma; Animals; Dopamine; Fluorescent Dyes; gamma-Aminobutyric Acid; Glucagon; Glycine; Immunohistochemistry; Isoquinolines; Neurotransmitter Agents; Retina; Tyrosine 3-Monooxygenase

1991
Glucose in glucagon release.
    Nature, 1990, Apr-19, Volume: 344, Issue:6268

    Topics: Calcium; gamma-Aminobutyric Acid; Glucagon; Glucose; Islets of Langerhans

1990
How secretion is inhibited.
    Nature, 1990, Mar-22, Volume: 344, Issue:6264

    Topics: Animals; Calcium; gamma-Aminobutyric Acid; Glucagon; Glucose; Secretory Rate

1990
Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels.
    Nature, 1989, Sep-21, Volume: 341, Issue:6239

    Topics: Animals; Bicuculline; Chloride Channels; Chlorides; Electric Conductivity; gamma-Aminobutyric Acid; Glucagon; Glucose; Guinea Pigs; In Vitro Techniques; Islets of Langerhans; Membrane Potentials; Membrane Proteins; Receptors, GABA-A; Secretory Rate

1989
High-affinity GABA uptake in a subpopulation of somatostatin cells in rat pancreas.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 1989, Volume: 37, Issue:7

    Topics: Animals; Autoradiography; Cholecystokinin; Cytoplasmic Granules; gamma-Aminobutyric Acid; Glicentin; Glucagon; Glucagon-Like Peptides; Immunohistochemistry; Islets of Langerhans; Microscopy, Electron; Pancreatic Polypeptide; Peptide Fragments; Protein Precursors; Rats; Rats, Inbred Strains; Somatostatin

1989
Neurotransmitter release by certain neuropeptides in the chicken retina.
    Acta ophthalmologica, 1985, Volume: 63, Issue:5

    Topics: Animals; Chickens; Dopamine; Enkephalin, Leucine; Female; gamma-Aminobutyric Acid; Glucagon; Glycine; Male; Nerve Tissue Proteins; Neurotensin; Neurotransmitter Agents; Retina; Serotonin; Somatostatin

1985
Elevation of somatostatin content, and reduction of somatostatin release by GABA in rat pancreatic islets.
    The Kobe journal of medical sciences, 1986, Volume: 32, Issue:1

    Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Glucagon; Insulin; Islets of Langerhans; Rats; Somatostatin

1986
Immunohistochemical colocalization of GABA and insulin in beta-cells of rat islet.
    Diabetes, 1986, Volume: 35, Issue:10

    Topics: Animals; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glucagon; Insulin; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Somatostatin

1986
Putative neurotransmitters in the retinae of three urodele species (Triturus alpestris, Salamandra salamandra, Pleurodeles waltli).
    Cell and tissue research, 1988, Volume: 252, Issue:2

    Topics: Animals; Enkephalin, Methionine; gamma-Aminobutyric Acid; Glucagon; Immunohistochemistry; Neurons; Neurotensin; Neurotransmitter Agents; Pleurodeles; Retina; Salamandra; Salamandridae; Serotonin; Triturus

1988
Insulin and glucagon secretion by the dog pancreas during intravenous and oral administration of gamma aminobutyric acid (GABA).
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1985, Volume: 17, Issue:6

    Topics: Administration, Oral; Animals; Dogs; gamma-Aminobutyric Acid; Glucagon; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Secretory Rate

1985
Effects of gamma-aminobutyric acid on insulin, glucagon, and somatostatin release from isolated perfused dog pancreas.
    Endocrinology, 1983, Volume: 113, Issue:1

    Topics: Animals; Bicuculline; Dogs; gamma-Aminobutyric Acid; Glucagon; Insulin; Male; Pancreas; Perfusion; Somatostatin; Time Factors

1983
Modulation by the hypothalamus of glucagon and insulin secretion in rabbits: studies with electrical and chemical stimulations.
    Endocrinology, 1981, Volume: 108, Issue:2

    Topics: Acetylcholine; Animals; Blood Glucose; Dopamine; Electric Stimulation; gamma-Aminobutyric Acid; Glucagon; Hypothalamus; Insulin; Insulin Secretion; Male; Rabbits; Serotonin

1981
In vivo effects of glucose and insulin on secretion and gene expression of glucagon in rats.
    Endocrinology, 1995, Volume: 136, Issue:12

    Topics: Animals; Arginine; Blood Glucose; Female; gamma-Aminobutyric Acid; Gene Expression Regulation; Glucagon; Glucose; Insulin; Rats; Rats, Wistar; RNA, Messenger

1995
Glucose modulates gamma-aminobutyric acid release from the pancreatic beta TC6 cell line.
    The Journal of biological chemistry, 1995, Dec-22, Volume: 270, Issue:51

    Topics: Animals; Antigens, Polyomavirus Transforming; Bicuculline; Cell Line; gamma-Aminobutyric Acid; Glucagon; Glucose; Insulin; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Promoter Regions, Genetic; Rats

1995
Chromium and other insulin sensitizers may enhance glucagon secretion: implications for hypoglycemia and weight control.
    Medical hypotheses, 1996, Volume: 46, Issue:2

    Topics: Chromium; Down-Regulation; gamma-Aminobutyric Acid; Glucagon; Humans; Hypoglycemia; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Models, Biological; Weight Loss

1996
Glucose homeostasis with infinite gain: further lessons from the Daisyworld parable?
    The Journal of endocrinology, 1997, Volume: 154, Issue:2

    Topics: Chromogranin A; gamma-Aminobutyric Acid; Glucagon; Glucose; Homeostasis; Humans; Insulin; Islets of Langerhans; Liver; Models, Biological; Pancreatic Hormones

1997
Immunocytochemical characterization of quisqualic acid- and N-methyl-D-aspartate-induced excitotoxicity in the retina of chicks.
    The Journal of comparative neurology, 1998, Mar-30, Volume: 393, Issue:1

    Topics: Animals; Antibody Specificity; Biomarkers; Carrier Proteins; Chickens; Choline O-Acetyltransferase; Dopamine; Enkephalin, Methionine; Excitatory Amino Acid Agonists; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glucagon; Glutamate Decarboxylase; Immunohistochemistry; Intracellular Membranes; Isoenzymes; Lysosomes; Male; Membrane Proteins; Membrane Transport Proteins; Myopia; N-Methylaspartate; Neurotoxins; Organic Anion Transporters; Parvalbumins; Protein Kinase C; Protein Kinase C beta; Protein Kinase C-alpha; Quisqualic Acid; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Retina; Serotonin; Tyrosine 3-Monooxygenase; Vasoactive Intestinal Peptide

1998
Quantitative measurement of islet glucagon response to hypoglycemia by confocal fluorescence imaging in diabetic rats: effects of phlorizin treatment.
    Endocrine, 1997, Volume: 7, Issue:3

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fluorescent Antibody Technique, Direct; gamma-Aminobutyric Acid; Glucagon; Hypoglycemia; Hypoglycemic Agents; Image Processing, Computer-Assisted; Insulin; Islets of Langerhans; Male; Microscopy, Confocal; Phlorhizin; Rats; Rats, Sprague-Dawley

1997
Distribution of neurotransmitters and their effects on glucagon secretion from the in vitro normal and diabetic pancreatic tissues.
    Tissue & cell, 2000, Volume: 32, Issue:3

    Topics: Acetylcholine; Animals; Biogenic Monoamines; Choline O-Acetyltransferase; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Glucagon; In Vitro Techniques; Neurotransmitter Agents; Pancreas; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase

2000
Correlation between GABA release from rat islet beta-cells and their metabolic state.
    American journal of physiology. Endocrinology and metabolism, 2002, Volume: 282, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Calcium; Culture Media, Conditioned; Cycloheximide; Diazoxide; gamma-Aminobutyric Acid; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamate Decarboxylase; Glyburide; Islets of Langerhans; Male; Mannoheptulose; Oxidation-Reduction; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Verapamil

2002
Vesicular inhibitory amino acid transporter is present in glucagon-containing secretory granules in alphaTC6 cells, mouse clonal alpha-cells, and alpha-cells of islets of Langerhans.
    Diabetes, 2003, Volume: 52, Issue:8

    Topics: Adenosine Triphosphate; Amino Acid Transport Systems; Animals; Carrier Proteins; Clone Cells; COS Cells; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glucagon; Islets of Langerhans; Male; Membrane Transport Proteins; Mice; PC12 Cells; Rats; Rats, Wistar; Secretory Vesicles; Vesicular Glutamate Transport Protein 2; Vesicular Inhibitory Amino Acid Transport Proteins; Vesicular Transport Proteins

2003
Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.
    Diabetes, 2004, Volume: 53, Issue:4

    Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Glucagon; Glucose; Islets of Langerhans; Protein Subunits; Pyridazines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA-A; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Transcription, Genetic

2004
Glycine, GABA and their transporters in pancreatic islets of Langerhans: evidence for a paracrine transmitter interplay.
    Journal of cell science, 2004, Aug-01, Volume: 117, Issue:Pt 17

    Topics: Animals; Biological Transport; Cell Membrane; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Glucagon; Glycine; Immunohistochemistry; Islets of Langerhans; Membrane Transport Proteins; Microscopy, Confocal; Microscopy, Electron; Microscopy, Fluorescence; Microscopy, Immunoelectron; Models, Biological; Neurons; Neurosecretory Systems; Pancreas; Rats; Rats, Wistar; Signal Transduction

2004
Suprachiasmatic GABAergic inputs to the paraventricular nucleus control plasma glucose concentrations in the rat via sympathetic innervation of the liver.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Sep-01, Volume: 24, Issue:35

    Topics: Animals; Axonal Transport; Bicuculline; Blood Glucose; Circadian Rhythm; Clonidine; Corticosterone; gamma-Aminobutyric Acid; Glucagon; Gluconeogenesis; Herpesvirus 1, Suid; Hyperglycemia; Hypothalamus; Insulin; Isoproterenol; Liver; Male; Microdialysis; Muscimol; N-Methylaspartate; Norepinephrine; Parasympathectomy; Parasympathetic Nervous System; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Suprachiasmatic Nucleus; Sympathectomy; Sympathetic Nervous System; Tetrodotoxin; Vasopressins

2004
Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function.
    The Journal of comparative neurology, 2005, May-02, Volume: 485, Issue:2

    Topics: Animals; Autonomic Nervous System; Body Temperature; Cell Count; Cholera Toxin; Drinking; Eating; Functional Laterality; gamma-Aminobutyric Acid; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Heart Rate; Hypothalamus; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Medulla Oblongata; Microinjections; Motor Activity; Neural Pathways; Neuropeptides; Orexins; Peptide Fragments; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Time Factors; Tyrosine 3-Monooxygenase; Vagus Nerve

2005
ATP-sensitive K(+) channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia.
    Diabetes, 2007, Volume: 56, Issue:4

    Topics: Animals; Blood Glucose; Diazoxide; Epinephrine; gamma-Aminobutyric Acid; Glucagon; Glucose Clamp Technique; Hypoglycemia; Insulin; Male; Microdialysis; Microinjections; Potassium Channels; Rats; Rats, Sprague-Dawley; Ventromedial Hypothalamic Nucleus

2007
Glucose-dependent regulation of gamma-aminobutyric acid (GABA A) receptor expression in mouse pancreatic islet alpha-cells.
    Diabetes, 2007, Volume: 56, Issue:2

    Topics: Animals; Calcium; Dose-Response Relationship, Drug; Female; GABA Antagonists; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Glucose; Insulin; Islets of Langerhans; Mice; Potassium; Protein Subunits; Pyridazines; Receptors, GABA-A; RNA, Messenger

2007
Recurrent hypoglycemia alters hypothalamic expression of the regulatory proteins FosB and synaptophysin.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2008, Volume: 295, Issue:5

    Topics: Adrenocorticotropic Hormone; Animals; Blood Glucose; Blotting, Western; Epinephrine; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glucagon; Hydrocortisone; Hypoglycemia; Hypothalamus; Hypothalamus, Middle; Immunohistochemistry; Male; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Recurrence; Synaptophysin; Thyrotropin-Releasing Hormone; Vasopressins

2008
Diabetes mellitus decreases the expression of calcitonin-gene related peptide, gamma-amino butyric acid and glutamic acid decarboxylase in human pancreatic islet cells.
    Neuro endocrinology letters, 2009, Volume: 30, Issue:4

    Topics: Calcitonin Gene-Related Peptide; Diabetes Mellitus, Type 2; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Glucagon; Glutamate Decarboxylase; Humans; Insulin; Insulin-Secreting Cells; Pancreatectomy; Pancreatic Neoplasms

2009
Reduction of plasma membrane glutamate transport potentiates insulin but not glucagon secretion in pancreatic islet cells.
    Molecular and cellular endocrinology, 2011, May-16, Volume: 338, Issue:1-2

    Topics: Alanine; Animals; Aspartic Acid; Cell Membrane; Cells, Cultured; Dicarboxylic Acids; Epinephrine; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Glucose; Glutamate Plasma Membrane Transport Proteins; Glutamic Acid; Glutamine; Insulin; Insulin Secretion; Insulin-Secreting Cells; Ketoglutaric Acids; Malates; Male; Pyrrolidines; Rats; Rats, Wistar; Transcription, Genetic

2011
GABA promotes human β-cell proliferation and modulates glucose homeostasis.
    Diabetes, 2014, Volume: 63, Issue:12

    Topics: Animals; Apoptosis; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; GABA Agents; gamma-Aminobutyric Acid; Glucagon; Homeostasis; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans Transplantation; Mice; Mice, Inbred NOD; Mice, SCID

2014
Effects of γ-Aminobutyric Acid A Receptor Activation on Counterregulatory Responses to Subsequent Exercise in Individuals With Type 1 Diabetes.
    Diabetes, 2016, Volume: 65, Issue:9

    Topics: Adult; Alprazolam; Animals; Autonomic Nervous System; Benzodiazepines; Diabetes Mellitus, Type 1; Epinephrine; Female; gamma-Aminobutyric Acid; Glucagon; Humans; Hydrocortisone; Lipolysis; Male; Norepinephrine; Receptors, GABA-A

2016
Paracrine GABA and insulin regulate pancreatic alpha cell proliferation in a mouse model of type 1 diabetes.
    Diabetologia, 2017, Volume: 60, Issue:6

    Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Male; Mice; Mice, Inbred C57BL; Muscimol

2017
GABA and insulin but not nicotinamide augment α- to β-cell transdifferentiation in insulin-deficient diabetic mice.
    Biochemical pharmacology, 2022, Volume: 199

    Topics: Animals; Blood Glucose; Cell Transdifferentiation; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Glucagon; Glucagon-Secreting Cells; Insulin; Insulin-Secreting Cells; Mice; Niacinamide; Streptozocin

2022
γ-aminobutyric acid modulates α-cell hyperplasia but not β-cell regeneration induced by glucagon receptor antagonism in type 1 diabetic mice.
    Acta diabetologica, 2023, Volume: 60, Issue:1

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; gamma-Aminobutyric Acid; Glucagon; Hyperplasia; Insulin; Insulin-Secreting Cells; Mice; Receptors, Glucagon; Regeneration

2023