glucagon has been researched along with exendin (9-39) in 82 studies
| Studies (glucagon) | Trials (glucagon) | Recent Studies (post-2010) (glucagon) | Studies (exendin (9-39)) | Trials (exendin (9-39)) | Recent Studies (post-2010) (exendin (9-39)) |
|---|---|---|---|---|---|
| 26,039 | 1,498 | 3,054 | 247 | 23 | 141 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 33 (40.24) | 18.2507 |
| 2000's | 30 (36.59) | 29.6817 |
| 2010's | 18 (21.95) | 24.3611 |
| 2020's | 1 (1.22) | 2.80 |
| Authors | Studies |
|---|---|
| Kawai, K; Ohashi, S; Watanabe, Y; Yamashita, K; Yokota, C | 1 |
| Fehmann, HC; Göke, B; Göke, R; Kolligs, F | 1 |
| Bloom, SR; Ghatei, MA; Owji, AA; Smith, DM; Wang, RM; Wang, Z | 1 |
| Classen, M; Dehne, K; Eng, J; Holst, JJ; Raufman, JP; Riedel, T; Schepp, W; Schmidtler, J; Schusdziarra, V | 1 |
| Boyd, AE; Fehmann, HC; Göke, B; Jiang, J; Schweinfurth, J; Wheeler, MB | 1 |
| Beak, SA; Bloom, SR; Choi, SJ; Edwards, CM; Ghatei, MA; Gunn, I; Heath, MM; Herbert, J; Lambert, PD; Meeran, K; O'Shea, D; Smith, DM; Taylor, GM; Turton, MD; Wilding, JP | 1 |
| D'Alessio, DA; Eng, J; Ensinck, JW; Koerker, D; Laschansky, E; Prigeon, R; Vogel, R | 1 |
| Graziano, MP; Hey, PJ; Strader, CD | 1 |
| Bloom, S; Chen, X; Gunn, I; Herbert, J; O'Shea, D | 1 |
| Beak, SA; Bloom, SR; Gunn, I; O'Shea, D; Turton, MD | 1 |
| Crespel, A; De Boisvilliers, F; Gros, L; Kervran, A | 1 |
| Boissard, C; Breant, B; Marie, JC; Rosselin, G; Skoglund, G | 1 |
| Adelhorst, K; Kirk, O; Kofod, H | 1 |
| Barragán, JM; Blázquez, E; Eng, J; Rodríguez, RE | 1 |
| Bernstein, IL; Seeley, RJ; Thiele, TE; van Dijk, G; Woods, SC | 1 |
| Alcántara, AI; Clemente, F; Delgado, E; López-Delgado, MI; Luque, MA; Malaisse, WJ; Morales, M; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Beday, A; Eng, J; Montrose-Rafizadeh, C; Pritchette, LA; Rodgers, BD; Yang, H | 1 |
| Jessop, DS; Larsen, PJ; Tang-Christensen, M | 1 |
| Bloom, SR; Edwards, CM; Ghatei, MA; Goldstone, AP; Gunn, I; Heath, MM; Hoggard, N; Howard, JK; Meeran, K; Mercer, JG; Moar, KM; O'Shea, D; Rasheed, S; Rossi, M; Small, C; Steere, J; Turton, MD | 1 |
| Flamez, D; Ling, Z; Moens, K; Pipeleers, D; Schuit, F; Van Schravendijk, C | 1 |
| Beak, SA; Bloom, SR; Buckingham, JC; Ghatei, MA; Heath, MM; Morgan, DG; Small, CJ; Smith, DM; Taylor, AD | 1 |
| Arnold, R; Göke, B; Katschinski, M; Leicht, P; Schirra, J; Sturm, K | 1 |
| Efendic, S; Gutniak, M; Hellström, PM; Holst, JJ; Tolessa, T | 1 |
| Egan, JM; Montrose, MH; Montrose-Rafizadeh, C; Moyes, CD; Roth, J; Wang, Y; Yang, H | 1 |
| Dolci, W; Drucker, D; Efrat, S; Schaerer, E; Scrocchi, L; Serre, V; Thorens, B | 1 |
| Eckart, K; Leonhardt, U; Ottleben, M; Ramadori, G; Ritzel, U; Rühmann, A; Spiess, J | 1 |
| Abusnana, S; Bloom, SR; Choi, SJ; Edwards, CM; Ghatei, MA; Goldstone, AP; Gunn, I; Heath, MM; Meeran, K; O'Shea, D; Rossi, M; Small, CJ; Steere, J; Sunter, D; Taylor, GM; Turton, MD | 1 |
| Bloom, SR; Edwards, CM; Ghatei, MA; Mahmoudi, M; Todd, JF; Wang, RM; Wang, Z | 1 |
| Tseng, CC; Wolfe, MM; Zhang, XY | 1 |
| Burton, PS; Colca, JR; Elhammer, AP; Meurer, JA | 1 |
| Goto, N; Kameyama, T; Oka, JI | 1 |
| Goto, N; Kameyama, T; Oka, J; Suzuki, E | 1 |
| Ahrén, B; Pacini, G | 1 |
| Ito, T; Kawai, K; Kawakami, S; Nakabayashi, H; Nakagawa, A; Niijima, A; Nishizawa, M; Uchida, K | 1 |
| Bozkurt, A; Coşkun, T; Gülpinar, MA; Ulusoy, NB; Yegen, BC | 1 |
| Larsen, PJ; Rømer, J; Tang-Christensen, M; Thulesen, J; Vrang, N | 1 |
| Ebinger, M; Fehmann, HC; Fussgaenger, RD; Jehle, DR; Jehle, PM | 1 |
| Baggio, L; Drucker, DJ; Kieffer, TJ | 1 |
| Bondareva, VM; Leonard, JB; Plisetskaya, EM; Silverstein, JT | 1 |
| Burcelin, R; Da Costa, A; Drucker, D; Thorens, B | 1 |
| Anderson, GH; Brubaker, PL; Choi, YH; Peters, CT | 1 |
| Cancelas, J; Malaisse, WJ; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Bojanowska, E; Stempniak, B | 1 |
| Bloom, SR; Coppock, HA; Ghatei, MA; Khoshdel, Z; Owji, AA; Panjehshahin, MR; Sanea, F; Shojaee Fard, M; Smith, DM | 1 |
| Ahn, JM; Berger, V; Hruby, VJ; Moens, K; Pipeleers, D; Schuit, F; Van Schravendijk, C | 1 |
| Acitores, A; González, N; Luque, MA; Márquez, L; Morales, M; Redondo, A; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Anvari, M; Daniel, EE; Fox-Threlkeld, JE; McDonald, TJ | 1 |
| Flatt, PR; Gault, VA; Green, BD; Harriott, P; Mooney, MH; O'Harte, FP | 1 |
| Macchi, C; Malendowicz, LK; Nowak, KW; Nussdorfer, GG; Ziolkowska, A; Zyterska, A | 1 |
| Schick, RR; Schusdziarra, V; vorm Walde, T; Zimmermann, JP | 1 |
| Banks, WA; During, MJ; Niehoff, ML | 1 |
| Bailey, CJ; Flatt, PR; Gault, VA; Green, BD; Greer, B; Harriott, P; Irwin, N; Mooney, MH; O'Harte, FP | 1 |
| Baggio, LL; Brown, TJ; Drucker, DJ; Huang, Q | 1 |
| Acuna-Goycolea, C; van den Pol, A | 1 |
| Gonon, AT; Nyström, T; Pernow, J; Sjöholm, A | 1 |
| Acitores, A; González, N; Sancho, V; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Chelikani, PK; Haver, AC; Reidelberger, RD | 1 |
| Ayachi, SE; Bali, JP; Borie, F; Jarrousse, C; le Nguyen, D; Magous, R; Millat, B; Sasaki, K | 1 |
| D'Amico, E; Di Mario, U; Hui, H; Khoury, N; Perfetti, R | 1 |
| Bailey, CJ; Flatt, PR; Gault, VA; Green, BD; Irwin, N; O'Harte, FP | 1 |
| González, N; Malaisse, WJ; Sancho, V; Trigo, MV; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Barucci, N; Burns, M; Buxton, JM; Clairmont, KB; Claus, TH; Livingston, JN; Ortiz, AA; Pan, CQ; Reynolds, JC; Roczniak, S; Whelan, JP; Yang, L | 1 |
| Bergman, RN; Ionut, V; Stefanovski, D; Zheng, D | 1 |
| Graham, M; Gu, W; Komorowski, R; Lindberg, RA; Liu, Q; Meng, T; Moore, S; Motani, AS; Rulifson, IC; Sivits, G; Véniant, MM; Wang, P; Winters, KA; Wu, X; Yan, H; Zhang, Y | 1 |
| Brödl, J; Göke, B; Linke, R; Nicolaus, M; Schirra, J; Woerle, HJ | 1 |
| Grybäck, P; Hellström, PM; Hilsted, L; Holst, JJ; Jacobsson, H; Näslund, E; Schmidt, PT; Witte, AB | 1 |
| Holst, JJ; Kielgast, U; Madsbad, S | 1 |
| Cherrington, AD; Farmer, B; Farmer, T; Johnson, KM; Neal, D; Patrick Donahue, E; Schurr, K | 1 |
| Carneiro, L; Derani, A; Göke, B; Schirra, J; Woerle, HJ | 1 |
| Calabria, AC; De León, DD; Gallagher, PR; Li, C; Stanley, CA | 1 |
| Casamitjana, R; Jiménez, A; Lacy, A; Viaplana-Masclans, J; Vidal, J | 1 |
| Cobelli, C; Dalla Man, C; Farrugia, LP; Miles, JM; Piccinini, F; Rizza, RA; Sathananthan, M; Vella, A; Zinsmeister, AR | 1 |
| Bojsen-Møller, KN; Dirksen, C; Hansen, DL; Holst, JJ; Jacobsen, SH; Jørgensen, NB; Kristiansen, VB; Madsbad, S; Naver, L; Worm, D | 1 |
| D'Alessio, DA; Gastaldelli, A; Salehi, M | 1 |
| Beglinger, C; Fischer, H; Goeke, B; Kienle, P; Meyer-Gerspach, AC; Schirra, J; Schulte, F; Steinert, RE | 1 |
| Bendtsen, F; Bojsen-Møller, KN; Dirksen, C; Hartmann, B; Holst, JJ; Jørgensen, NB; Kristiansen, VB; Madsbad, S; Nielsen, S; Svane, MS | 1 |
| Dusaulcy, R; Gosmain, Y; Gribble, F; Handgraaf, S; Heddad-Masson, M; Philippe, J; Reimann, F; Skarupelova, S; Vesin, C; Visentin, F | 1 |
| Craig, CM; Deacon, CF; Holst, JJ; Liu, LF; McLaughlin, TL | 1 |
| Dionisi-Vici, C; Maiorana, A | 1 |
| Bahekar, R; Jain, MR; Joharapurkar, A; Kshirsagar, S; Pandey, D; Patel, D; Patel, HM; Patel, M; Patel, V; Sutariya, B | 1 |
| Bloom, SR; Minnion, J; Scott, R; Tan, T | 1 |
| Ahrén, B; Seino, Y; Yamada, Y | 1 |
2 review(s) available for glucagon and exendin (9-39)
| Article | Year |
|---|---|
Central glucagon-like peptide-I in the control of feeding.
Topics: Animals; Brain; Feeding Behavior; Genes, fos; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Hyperglycemia; Hyperinsulinism; Neurons; Peptide Fragments; Protein Precursors; Rats; Rats, Zucker; Receptors, Glucagon; Venoms | 1996 |
Hyperinsulinemic hypoglycemia: clinical, molecular and therapeutical novelties.
Topics: Adenosine Triphosphate; Animals; Child; Child, Preschool; Congenital Hyperinsulinism; Diet, Ketogenic; Galactose; Glucagon; Humans; Hypoglycemia; Infant; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Nervous System Diseases; Peptide Fragments; Potassium Channels; Receptor, Insulin; Sirolimus; Somatostatin; Treatment Outcome | 2017 |
7 trial(s) available for glucagon and exendin (9-39)
| Article | Year |
|---|---|
Exendin(9-39)amide is an antagonist of glucagon-like peptide-1(7-36)amide in humans.
Topics: Adult; C-Peptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Humans; Insulin; Male; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Time Factors | 1998 |
Antidiabetic actions of endogenous and exogenous GLP-1 in type 1 diabetic patients with and without residual β-cell function.
Topics: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 1; Female; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; Male; Peptide Fragments; Triglycerides; Young Adult | 2011 |
The role of endogenous incretin secretion as amplifier of glucose-stimulated insulin secretion in healthy subjects and patients with type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose Clamp Technique; Humans; Incretins; Insulin; Insulin Secretion; Male; Middle Aged; Peptide Fragments; Receptors, Glucagon | 2012 |
GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive K+ channel.
Topics: Adolescent; Adult; Blood Glucose; Congenital Hyperinsulinism; Cross-Over Studies; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Infant, Newborn; Insulin; Insulin Secretion; Islets of Langerhans; KATP Channels; Male; Mutation; Peptide Fragments; Pilot Projects; Receptors, Glucagon | 2012 |
Effect of glucagon-like peptide-1 receptor antagonism on appetite and food intake in healthy men.
Topics: Adolescent; Adult; Appetite; Appetite Depressants; Cross-Over Studies; Double-Blind Method; Drinking Behavior; Energy Intake; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Infusions, Intravenous; Male; Peptide Fragments; Peptide YY; Postprandial Period; Receptors, Glucagon; Up-Regulation; Vomiting; Young Adult | 2014 |
Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery.
Topics: Adult; Blood Glucose; C-Peptide; Cross-Over Studies; Enzyme-Linked Immunosorbent Assay; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Humans; Hypoglycemic Agents; Linear Models; Male; Obesity; Peptide Fragments; Postprandial Period; Single-Blind Method; Sitagliptin Phosphate | 2016 |
Critical role for GLP-1 in symptomatic post-bariatric hypoglycaemia.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glucose Tolerance Test; Humans; Hypoglycemia; Insulin; Male; Middle Aged; Peptide Fragments; Surveys and Questionnaires | 2017 |
73 other study(ies) available for glucagon and exendin (9-39)
| Article | Year |
|---|---|
Evidence that glucagon stimulates insulin secretion through its own receptor in rats.
Topics: Animals; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Perfusion; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Time Factors; Venoms | 1995 |
Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amide.
Topics: Animals; Drug Interactions; Exenatide; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Insulin; Male; Peptide Fragments; Peptides; Protein Precursors; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Glucagon; Venoms | 1995 |
Glucagon-like peptide-1 is a physiological incretin in rat.
Topics: Anesthesia; Animals; Arginine; Cells, Cultured; Consciousness; Eating; Fasting; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Infusions, Intravenous; Insulin; Insulin Secretion; Male; Pancreas; Peptide Fragments; Peptides; Protein Precursors; Radioligand Assay; Rats; Rats, Wistar; Receptors, Glucagon; Vasoactive Intestinal Peptide | 1995 |
Exendin-4 and exendin-(9-39)NH2: agonist and antagonist, respectively, at the rat parietal cell receptor for glucagon-like peptide-1-(7-36)NH2.
Topics: Aminopyrine; Animals; Binding, Competitive; Cell Membrane; Cross-Linking Reagents; Cyclic AMP; Exenatide; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; In Vitro Techniques; Lizards; Parietal Cells, Gastric; Peptide Fragments; Peptides; Rats; Rats, Wistar; Receptors, Glucagon; Venoms | 1994 |
Stable expression of the rat GLP-I receptor in CHO cells: activation and binding characteristics utilizing GLP-I(7-36)-amide, oxyntomodulin, exendin-4, and exendin(9-39).
Topics: Animals; CHO Cells; Cricetinae; Evaluation Studies as Topic; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Lizards; Neurotransmitter Agents; Oxyntomodulin; Peptide Fragments; Peptides; Rats; Receptors, Cell Surface; Receptors, Glucagon; Venoms | 1994 |
A role for glucagon-like peptide-1 in the central regulation of feeding.
Topics: Animals; Cerebral Ventricles; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intraventricular; Male; Neuropeptide Y; Peptide Fragments; Proto-Oncogene Proteins c-fos; Rats; Satiation | 1996 |
Elimination of the action of glucagon-like peptide 1 causes an impairment of glucose tolerance after nutrient ingestion by healthy baboons.
Topics: Animals; Antibodies, Monoclonal; Blood Glucose; Fasting; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Insulin; Male; Papio; Peptide Fragments; Receptors, Glucagon; Xylose | 1996 |
The amino terminal domain of the glucagon-like peptide-1 receptor is a critical determinant of subtype specificity.
Topics: Amino Acid Sequence; Animals; Base Sequence; Cell Line; Chlorocebus aethiops; Cyclic AMP; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptide Fragments; Peptides; Protein Precursors; Rats; Receptors, Glucagon; Recombinant Fusion Proteins; Venoms | 1996 |
A role for central glucagon-like peptide-1 in temperature regulation.
Topics: Animals; Body Temperature; Body Temperature Regulation; Central Nervous System; Eating; Glucagon; Glucagon-Like Peptide 1; Heart Rate; Injections, Intraperitoneal; Injections, Intraventricular; Male; Peptide Fragments; Protein Precursors; Rats; Telemetry | 1996 |
Effects of glucagon and glucagon-like peptide-1-(7-36) amide on C cells from rat thyroid and medullary thyroid carcinoma CA-77 cell line.
Topics: Animals; Binding, Competitive; Calcitonin; Carcinoma, Medullary; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Peptide Fragments; Perfusion; Rats; Rats, Wistar; Thyroid Gland; Thyroid Neoplasms; Tumor Cells, Cultured | 1996 |
Glucagon acts through its own receptors in the presence of functional glucagon-like peptide-1 receptors on hamster insulinoma.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Line; Cell Membrane; Cricetinae; Cross-Linking Reagents; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Islets of Langerhans; Mice; Pancreatic Neoplasms; Peptide Fragments; Peptides; Receptors, Glucagon; RNA, Messenger | 1996 |
Beta-cell receptors for glucagon/GLP-1? Properties of exendin(9-39) in mouse islets.
Topics: Animals; Cells, Cultured; Glucagon; Glucagon-Like Peptide 1; Islets of Langerhans; Mice; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Venoms | 1996 |
Interactions of exendin-(9-39) with the effects of glucagon-like peptide-1-(7-36) amide and of exendin-4 on arterial blood pressure and heart rate in rats.
Topics: Animals; Blood Pressure; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Heart Rate; Male; Peptide Fragments; Peptides; Rats; Rats, Sprague-Dawley; Venoms | 1996 |
Glucagon-like peptide-1 and satiety.
Topics: Animals; Avoidance Learning; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Neuropeptides; Peptide Fragments; Proto-Oncogene Proteins c-fos; Rats; Saccharin; Satiety Response; Taste | 1997 |
Exendin-4 agonist and exendin(9-39)amide antagonist of the GLP-1(7-36)amide effects in liver and muscle.
Topics: Animals; Cyclic AMP; Energy Metabolism; Enzyme Activation; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glycogen; Glycogen Synthase; Insulin; Liver; Muscle, Skeletal; Peptide Fragments; Peptides; Phosphorylase a; Rats; Rats, Wistar; Venoms | 1997 |
High potency antagonists of the pancreatic glucagon-like peptide-1 receptor.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cyclic AMP; Exenatide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Molecular Sequence Data; Peptide Fragments; Peptides; Rats; Receptors, Glucagon; Recombinant Fusion Proteins; Sequence Deletion; Structure-Activity Relationship; Transfection; Venoms | 1997 |
Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Blood Glucose; Corticosterone; Corticotropin-Releasing Hormone; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamo-Hypophyseal System; Hypothalamus; Immunohistochemistry; Injections, Intraventricular; Male; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Peptide Fragments; Phenotype; Pituitary-Adrenal System; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Supraoptic Nucleus; Time Factors; Vasopressins | 1997 |
Leptin interacts with glucagon-like peptide-1 neurons to reduce food intake and body weight in rodents.
Topics: Animals; Body Weight; Carrier Proteins; DNA Probes; Eating; Gene Expression; Glucagon; Glucagon-Like Peptide 1; In Situ Hybridization; Leptin; Light; Male; Mice; Mice, Inbred Strains; Neurons; Peptide Fragments; Proglucagon; Protein Precursors; Proteins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Leptin; RNA, Messenger; Solitary Nucleus | 1997 |
Dual glucagon recognition by pancreatic beta-cells via glucagon and glucagon-like peptide 1 receptors.
Topics: Animals; Cells, Cultured; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulin; Iodine Radioisotopes; Islets of Langerhans; Liver; Male; Peptide Fragments; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 1998 |
Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line.
Topics: Animals; Calcium; Cyclic AMP; Cytoplasm; Dose-Response Relationship, Drug; Exenatide; Food Deprivation; Glucagon; Glucagon-Like Peptide 1; Gonadotropin-Releasing Hormone; Hypothalamus; Luteinizing Hormone; Male; Mice; Mice, Transgenic; Neurons; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Cell Surface; Time Factors; Tumor Cells, Cultured; Venoms | 1998 |
Inhibitory effect of glucagon-like peptide-1 on small bowel motility. Fasting but not fed motility inhibited via nitric oxide independently of insulin and somatostatin.
Topics: Animals; Drug Interactions; Eating; Electromyography; Fasting; Gastrointestinal Motility; Gastrointestinal Transit; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Insulin; Intestine, Small; Male; Myoelectric Complex, Migrating; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Somatostatin | 1998 |
GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cell Line; Cloning, Molecular; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycogen; Glycolysis; Insulin; Kinetics; Muscle, Skeletal; Pancreas; Peptide Fragments; Protein Precursors; Rats; Receptors, Glucagon; Recombinant Proteins; Transfection; Venoms | 1998 |
Exendin-(9-39) is an inverse agonist of the murine glucagon-like peptide-1 receptor: implications for basal intracellular cyclic adenosine 3',5'-monophosphate levels and beta-cell glucose competence.
Topics: Animals; Blotting, Northern; Cell Line; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Islets of Langerhans; Ligands; Mice; Peptide Fragments; Proglucagon; Protein Precursors; Receptors, Glucagon; RNA | 1998 |
A synthetic glucagon-like peptide-1 analog with improved plasma stability.
Topics: Animals; Chromatography, High Pressure Liquid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glucose; Humans; Insulin; Insulin Secretion; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Time Factors; Tumor Cells, Cultured | 1998 |
Repeated intracerebroventricular administration of glucagon-like peptide-1-(7-36) amide or exendin-(9-39) alters body weight in the rat.
Topics: Animals; Body Weight; Energy Intake; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Injections, Intraventricular; Male; Neurotransmitter Agents; Peptide Fragments; Rats; Rats, Wistar | 1999 |
Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39.
Topics: Cytokines; Eating; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Peptide Fragments; Protein Precursors | 1999 |
Effect of GIP and GLP-1 antagonists on insulin release in the rat.
Topics: Absorption; Animals; Blood Glucose; Dose-Response Relationship, Drug; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Insulin; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Gastrointestinal Hormone | 1999 |
Properties of native and in vitro glycosylated forms of the glucagon-like peptide-1 receptor antagonist exendin(9-39).
Topics: Animals; Chlorocebus aethiops; Cyclic AMP; Diabetes Mellitus, Type 2; Glucagon; Glucagon-Like Peptide 1; Glycosylation; Humans; In Vitro Techniques; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 1999 |
Glucagon-like peptide-1 modulates neuronal activity in the rat's hippocampus.
Topics: Animals; Aspartic Acid; Cerebral Cortex; Electroencephalography; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glutamic Acid; Glutamine; Hippocampus; Injections, Intraventricular; Male; Neurons; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Stimulation, Chemical; Ventromedial Hypothalamic Nucleus | 1999 |
Endogenous GLP-1 modulates hippocampal activity in beta-amyloid protein-treated rats.
Topics: Amyloid beta-Peptides; Animals; Avoidance Learning; Brain Chemistry; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Hippocampus; Immunohistochemistry; Injections, Intraventricular; Lateral Ventricles; Male; Memory Disorders; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon | 1999 |
Dose-related effects of GLP-1 on insulin secretion, insulin sensitivity, and glucose effectiveness in mice.
Topics: Animals; Blood Glucose; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Tolerance Test; Insulin; Insulin Resistance; Insulin Secretion; Mice; Mice, Inbred Strains; Peptide Fragments; Peptides; Protein Precursors | 1999 |
The hepatic vagal reception of intraportal GLP-1 is via receptor different from the pancreatic GLP-1 receptor.
Topics: Animals; Electrophysiology; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intravenous; Liver; Male; Neurons, Afferent; Pancreas; Peptide Fragments; Peptides; Portal Vein; Rats; Rats, Wistar; Receptors, Glucagon; Vagus Nerve; Venoms | 2000 |
Glucagon-like peptide (GLP-1) is involved in the central modulation of fecal output in rats.
Topics: Animals; Brain; Corticotropin-Releasing Hormone; Defecation; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Injections, Intraperitoneal; Injections, Intraventricular; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Restraint, Physical; Stress, Physiological | 2000 |
The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake.
Topics: Animals; Conditioning, Operant; Dorsomedial Hypothalamic Nucleus; Drinking; Eating; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Hypothalamus; Male; Neuropeptide Y; Neurotransmitter Agents; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Taste | 2000 |
Glucagon-like peptide-1 improves insulin and proinsulin binding on RINm5F cells and human monocytes.
Topics: Adult; Animals; Exenatide; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Humans; Insulin; Insulinoma; Male; Monocytes; Pancreatic Neoplasms; Peptide Fragments; Peptides; Proinsulin; Protein Precursors; Rats; Receptors, Glucagon; Tumor Cells, Cultured; Venoms | 2000 |
Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice.
Topics: Animals; Blood Glucose; Fasting; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Mice; Mice, Inbred Strains; Peptide Fragments; Protein Precursors | 2000 |
Neuropeptide regulation of feeding in catfish, Ictalurus punctatus: a role for glucagon-like peptide-1 (GLP-1)?
Topics: Animals; Eating; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Ictaluridae; Immune Sera; Neuropeptides; Peptide Fragments; Protein Precursors | 2001 |
Glucose competence of the hepatoportal vein sensor requires the presence of an activated glucagon-like peptide-1 receptor.
Topics: Animals; Blood Glucose; Catheters, Indwelling; Enzyme-Linked Immunosorbent Assay; Fasting; Femoral Vein; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Hepatic Veins; Homeostasis; Infusions, Intravenous; Metabolic Clearance Rate; Mice; Mice, Inbred C57BL; Peptide Fragments; Portal System; Portal Vein; Protein Precursors; Tritium; Venoms | 2001 |
A glucagon-like peptide-1 receptor agonist and an antagonist modify macronutrient selection by rats.
Topics: Animals; Appetite Regulation; Dietary Carbohydrates; Dietary Fats; Dietary Proteins; Energy Intake; Exenatide; Glucagon; Glucagon-Like Peptide-1 Receptor; Injections, Intraperitoneal; Male; Peptide Fragments; Peptides; Rats; Rats, Wistar; Receptors, Glucagon; Time Factors; Venoms | 2001 |
Suppression by exendin(9-39)amide of glucagon-like peptide-1 insulinotropic action in rats infused with dimethyl ester of succinic acid.
Topics: Animals; Blood Glucose; Glucagon; Glucagon-Like Peptide 1; Insulin; Lizards; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Venoms | 2001 |
tGLP-1 and release of vasopressin and oxytocin from the isolated rat hypothalamo-neurohypophysial system: effects of a tGLP-1 receptor agonist and antagonist.
Topics: Animals; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamo-Hypophyseal System; Hypothalamus, Middle; In Vitro Techniques; Male; Oxytocin; Peptide Fragments; Peptides; Rats; Rats, Wistar; Vasopressins | 2001 |
Effects of intracerebroventricular injection of glucagon like peptide-1 and its related peptides on serotonin metabolism and on levels of amino acids in the rat hypothalamus.
Topics: Animals; Down-Regulation; Exenatide; Glucagon; Glucagon-Like Peptide 1; Hypothalamus; Injections, Intraventricular; Male; Neurons; Neurotransmitter Agents; Peptide Fragments; Peptides; Protein Precursors; Rats; Rats, Sprague-Dawley; Serotonin; Venoms | 2002 |
Assessment of the role of interstitial glucagon in the acute glucose secretory responsiveness of in situ pancreatic beta-cells.
Topics: Animals; Cells, Cultured; Cricetinae; Drug Synergism; Extracellular Space; Fibroblasts; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Isoproterenol; Liver; Lung; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Signal Transduction | 2002 |
Glucagon-like peptide-1 (GLP-1) and glucose metabolism in human myocytes.
Topics: Analysis of Variance; Cells, Cultured; Culture Techniques; Dose-Response Relationship, Drug; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose; Glycogen Phosphorylase; Glycogen Synthase; Humans; Isoenzymes; Muscle, Skeletal; Myocardium; Peptide Fragments; Peptides; Protein Precursors; Receptors, Glucagon; Second Messenger Systems; Venoms | 2002 |
Local, exendin-(9-39)-insensitive, site of action of GLP-1 in canine ileum.
Topics: Animals; Capsaicin; Dogs; Drug Resistance; Electric Stimulation; Electrophysiology; Female; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide 1; Ileum; In Vitro Techniques; Injections, Intra-Arterial; Male; Peptide Fragments; Protein Precursors; Tissue Distribution | 2002 |
Effects of the novel (Pro3)GIP antagonist and exendin(9-39)amide on GIP- and GLP-1-induced cyclic AMP generation, insulin secretion and postprandial insulin release in obese diabetic (ob/ob) mice: evidence that GIP is the major physiological incretin.
Topics: Animals; Cells, Cultured; Cricetinae; Cricetulus; Cyclic AMP; Diabetes Mellitus; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Hyperinsulinism; Insulin; Insulin Secretion; Mice; Obesity; Peptide Fragments; Postprandial Period; Protein Precursors; Spectrometry, Mass, Electrospray Ionization | 2003 |
Effects of prolonged exendin-4 administration on entero-insular axis of normal and streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Exenatide; Female; Glucagon; Glucagon-Like Peptide-1 Receptor; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Liver Glycogen; Peptide Fragments; Peptides; Rats; Rats, Wistar; Receptors, Glucagon; Venoms | 2003 |
Peptides that regulate food intake: glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats.
Topics: Animals; Dose-Response Relationship, Drug; Feeding Behavior; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamic Area, Lateral; Hypothalamus, Middle; Male; Peptide Fragments; Rats; Rats, Wistar; Time Factors | 2003 |
Brain uptake of the glucagon-like peptide-1 antagonist exendin(9-39) after intranasal administration.
Topics: Administration, Intranasal; Animals; Autoradiography; Brain; Glucagon; Glucagon-Like Peptide 1; Iodine Radioisotopes; Male; Mice; Olfactory Bulb; Peptide Fragments; Protein Precursors; Tissue Distribution | 2004 |
Lys9 for Glu9 substitution in glucagon-like peptide-1(7-36)amide confers dipeptidylpeptidase IV resistance with cellular and metabolic actions similar to those of established antagonists glucagon-like peptide-1(9-36)amide and exendin (9-39).
Topics: Adenylyl Cyclases; Amino Acid Substitution; Animals; Blood Glucose; Cells, Cultured; Cricetinae; Cyclic AMP; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Fibroblasts; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Glutamic Acid; Humans; Hypoglycemic Agents; Insulin; Islets of Langerhans; Lung; Lysine; Mice; Mice, Obese; Peptide Fragments; Peptides; Receptors, Glucagon; Spectrometry, Mass, Electrospray Ionization | 2004 |
Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Brain; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Eating; Energy Metabolism; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Injections, Intraperitoneal; Injections, Intraventricular; Iodine Radioisotopes; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Oxyntomodulin; Peptide Fragments; Peptides; Proglucagon; Protein Precursors; Proto-Oncogene Proteins c-fos; Rats; Receptors, G-Protein-Coupled; Receptors, Glucagon; Venoms | 2004 |
Glucagon-like peptide 1 excites hypocretin/orexin neurons by direct and indirect mechanisms: implications for viscera-mediated arousal.
Topics: Action Potentials; Afferent Pathways; Animals; Arousal; Choline; Digestive System; Eating; Exenatide; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutamic Acid; Hypothalamic Hormones; Hypothalamus; Intracellular Signaling Peptides and Proteins; Melanins; Mice; Mice, Transgenic; Neurons; Neuropeptides; Orexin Receptors; Orexins; Paraventricular Hypothalamic Nucleus; Patch-Clamp Techniques; Peptide Fragments; Peptides; Pituitary Hormones; Protein Precursors; Receptors, G-Protein-Coupled; Receptors, Glucagon; Receptors, Neuropeptide; Sodium Channel Blockers; Solitary Nucleus; Synaptic Transmission; Tetrodotoxin; Venoms; Viscera | 2004 |
Glucagon-like peptide-1 relaxes rat conduit arteries via an endothelium-independent mechanism.
Topics: Acetylcholine; Animals; Arteries; Cardiotonic Agents; Cyclic AMP; Dose-Response Relationship, Drug; Endothelium, Vascular; Femoral Artery; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Peptide Fragments; Potassium; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 2005 |
Effect of GLP-1 on glucose transport and its cell signalling in human myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aged; Aged, 80 and over; Androstadienes; Biological Transport; Cells, Cultured; Enzyme Activation; Exenatide; Female; Flavonoids; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Indoles; Insulin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Cells; Peptide Fragments; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Venoms; Wortmannin | 2005 |
Intravenous infusion of glucagon-like peptide-1 potently inhibits food intake, sham feeding, and gastric emptying in rats.
Topics: Animals; Appetite Depressants; Diet; Dose-Response Relationship, Drug; Eating; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Infusions, Intravenous; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Glucagon | 2005 |
Contraction induced by glicentin on smooth muscle cells from the human colon is abolished by exendin (9-39).
Topics: Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Animals; Cells, Cultured; Colon; Dose-Response Relationship, Drug; Female; Glicentin; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Male; Middle Aged; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Peptide Fragments; Protein Precursors; Sequence Homology, Amino Acid | 2005 |
Pancreatic beta-cells expressing GLP-1 are resistant to the toxic effects of immunosuppressive drugs.
Topics: Animals; Antihypertensive Agents; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Caspase 3; Caspases; Cell Line, Tumor; Cell Survival; Diazoxide; DNA Fragmentation; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Immunosuppressive Agents; Insulin; Insulin Secretion; Intracellular Signaling Peptides and Proteins; Islets of Langerhans; Mice; Mitochondrial Proteins; Peptide Fragments; Protein Precursors; Proto-Oncogene Proteins c-bcl-2 | 2005 |
Chronic treatment with exendin(9-39)amide indicates a minor role for endogenous glucagon-like peptide-1 in metabolic abnormalities of obesity-related diabetes in ob/ob mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Insulin; Male; Mice; Mice, Obese; Obesity; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Time Factors | 2005 |
Effects of glucagon-like peptide-1 and exendins on kinase activity, glucose transport and lipid metabolism in adipocytes from normal and type-2 diabetic rats.
Topics: Adipocytes; Animals; Biological Transport, Active; Deoxyglucose; Diabetes Mellitus, Experimental; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; In Vitro Techniques; Lipid Metabolism; Lipids; Lipolysis; Male; Peptide Fragments; Peptides; Protein Kinases; Protein Precursors; Rats; Rats, Wistar; Venoms | 2005 |
Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Gastrointestinal Motility; Glucagon; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Insulin; Intercellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Mutant Strains; Obesity; Peptide Fragments; Peptides; Polyethylene Glycols; Rats; Rats, Wistar; Receptors, Glucagon | 2007 |
Exenatide can reduce glucose independent of islet hormones or gastric emptying.
Topics: Animals; Blood Glucose; Dogs; Exenatide; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Hypoglycemic Agents; Injections, Subcutaneous; Insulin; Islets of Langerhans; Peptide Fragments; Peptides; Postprandial Period; Venoms | 2008 |
Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor.
Topics: Animals; Antibodies, Monoclonal; Disease Models, Animal; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Peptide Fragments; Receptors, Glucagon; Signal Transduction | 2010 |
Endogenous GLP-1 regulates postprandial glycemia in humans: relative contributions of insulin, glucagon, and gastric emptying.
Topics: Adult; Blood Glucose; Body Mass Index; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Linear Models; Male; Peptide Fragments; Postprandial Period; Radioimmunoassay | 2011 |
Involvement of endogenous glucagon-like peptide-1 in regulation of gastric motility and pancreatic endocrine secretion.
Topics: Adult; Blood Glucose; Female; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucose; Humans; Hunger; Insulin; Male; Nausea; Pancreas; Peptide Fragments; Peptide YY; Postprandial Period; Satiation | 2011 |
Endogenously released GLP-1 is not sufficient to alter postprandial glucose regulation in the dog.
Topics: Acetaminophen; Animals; Blood Glucose; Dogs; Enteroendocrine Cells; Female; Food; Gastric Emptying; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Homeostasis; Insulin; Kinetics; Male; Peptide Fragments; Receptors, Glucagon | 2011 |
GLP-1 action and glucose tolerance in subjects with remission of type 2 diabetes after gastric bypass surgery.
Topics: C-Peptide; Diabetes Mellitus, Type 2; Female; Gastric Bypass; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Humans; Male; Middle Aged; Peptide Fragments | 2013 |
Direct effects of exendin-(9,39) and GLP-1-(9,36)amide on insulin action, β-cell function, and glucose metabolism in nondiabetic subjects.
Topics: Adult; Blood Glucose; Body Mass Index; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Insulin; Insulin-Secreting Cells; Male; Peptide Fragments; Peptides | 2013 |
Exaggerated glucagon-like peptide 1 response is important for improved β-cell function and glucose tolerance after Roux-en-Y gastric bypass in patients with type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Female; Gastric Bypass; Gastric Emptying; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Humans; Insulin Resistance; Insulin-Secreting Cells; Male; Middle Aged; Peptide Fragments; Receptors, Glucagon | 2013 |
Blockade of glucagon-like peptide 1 receptor corrects postprandial hypoglycemia after gastric bypass.
Topics: Adult; Blood Glucose; Case-Control Studies; Female; Gastric Bypass; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucagon-Secreting Cells; Humans; Hypoglycemia; Insulin; Insulin-Secreting Cells; Male; Middle Aged; Peptide Fragments; Receptors, Glucagon; Treatment Outcome | 2014 |
Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia.
Topics: Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Enteroendocrine Cells; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Hyperglycemia; Insulin-Secreting Cells; Male; Mice, Inbred C57BL; Mice, Transgenic; Obesity; Peptide Fragments; Phenotype | 2016 |
Balanced Coagonist of GLP-1 and Glucagon Receptors Corrects Dyslipidemia by Improving FGF21 Sensitivity in Hamster Model.
Topics: Adipose Tissue; Aminoisobutyric Acids; Animals; Bile; Cholesterol; Cricetinae; Diet, High-Fat; Dipeptides; Disease Models, Animal; Fibroblast Growth Factors; Glucagon; Glucagon-Like Peptide 1; Homeostasis; Hyperlipidemias; Lipolysis; Liver; Male; Peptide Fragments; Polyethylene Glycols; Receptors, Fibroblast Growth Factor; Receptors, Glucagon; Triglycerides | 2017 |
Oxyntomodulin analogue increases energy expenditure via the glucagon receptor.
Topics: Animals; Calorimetry, Indirect; Energy Metabolism; Glucagon; Male; Oxyntomodulin; Peptide Fragments; Rats; Rats, Wistar; Receptors, Glucagon | 2018 |
The mediation by GLP-1 receptors of glucagon-induced insulin secretion revisited in GLP-1 receptor knockout mice.
Topics: Animals; Blood Glucose; Disease Models, Animal; Glucagon; Glucagon-Like Peptide-1 Receptor; Glucose; Histone-Lysine N-Methyltransferase; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Knockout; Pancreas; Peptide Fragments | 2021 |