glucagon has been researched along with colforsin in 214 studies
| Studies (glucagon) | Trials (glucagon) | Recent Studies (post-2010) (glucagon) | Studies (colforsin) | Trials (colforsin) | Recent Studies (post-2010) (colforsin) |
|---|---|---|---|---|---|
| 26,039 | 1,498 | 3,054 | 13,460 | 46 | 1,298 |
| Protein | Taxonomy | glucagon (IC50) | colforsin (IC50) |
|---|---|---|---|
| nuclear receptor subfamily 0 group B member 1 | Homo sapiens (human) | 1.729 | |
| 5-hydroxytryptamine receptor 1A | Homo sapiens (human) | 0.041 | |
| Adenylate cyclase type 1 | Homo sapiens (human) | 0.0955 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 65 (30.37) | 18.7374 |
| 1990's | 101 (47.20) | 18.2507 |
| 2000's | 41 (19.16) | 29.6817 |
| 2010's | 6 (2.80) | 24.3611 |
| 2020's | 1 (0.47) | 2.80 |
| Authors | Studies |
|---|---|
| Itoh, N; Ohtani, R; Okamoto, H; Takano, M; Yayama, K | 1 |
| Amiel, C; Friedlander, G; Herman, P; Huy, PT | 1 |
| Ishac, EJ; Kunos, G; Lazar-Wesley, E | 1 |
| Somogyi, R; Stucki, JW; Zhao, M | 1 |
| Cote, P; Diehl, AM; Wand, GS; Yang, SQ | 1 |
| Brubaker, PL; Stobie-Hayes, KM | 2 |
| Absood, A; Chen, D; Håkanson, R | 1 |
| DeSilva, SE; Nagy, LE | 1 |
| Bataille, D; Demirpence, E; Gros, L; Jarrousse, C; Kervran, A | 1 |
| Fehmann, HC; Habener, JF | 1 |
| Benito, M; de Juan, C; Fabregat, I | 1 |
| Houslay, MD; Palmer, TM; Taberner, PV | 1 |
| Gross, R; Hillaire-Buys, D; Loubatières-Mariani, MM; Ribes, G | 1 |
| Farkas, EM; Papachristou, DN; Patel, YC; Zingg, HH | 1 |
| Amiel, C; Bernard, C; Ferrary, E; Friedlander, G; Sterkers, O | 1 |
| Boege, F; Cantrill, RC; Hahn, M; Heithier, H; Kurstjens, NP | 1 |
| Flores-Riveros, JR; Janicot, M; Kaestner, KH; Lane, MD; McLenithan, JC | 1 |
| Arnold, R; Bächle, R; Fehmann, HC; Göke, B; Göke, R; Wagner, B | 1 |
| Classen, M; Fürlinger, C; Janczewska, I; Schepp, W; Schmidtler, J; Schusdziarra, V; Weigert, N | 1 |
| Jansen, PL; Ottenhoff, R; Oude Elferink, RP; Roelofsen, H | 1 |
| Berrow, NS; Lacey, RJ; Morgan, NG; Scarpello, JH | 1 |
| De Cannière, D; Dehaye, JP; Pector, JC; Préat, V; Ravelingien, N | 1 |
| Houslay, MD; Palmer, TM | 1 |
| Bolaffi, JL; Grodsky, GM; Ma, YH; Rodd, G | 1 |
| Brubaker, PL; Campos, R; Drucker, DJ; Reynolds, R; Stobie, K | 1 |
| Ammon, HP; Anazodo, MI; Müller, AB; Safayhi, H | 1 |
| Brosnan, JT; Collett, VM; Hall, B; Jois, M | 1 |
| Garcia-Ruiz, C; Kaplowitz, N; Kuhlenkamp, J; Lu, SC; Ookhtens, M; Salas-Prato, M | 1 |
| Chow, SC; Duddy, SK; Kass, GE; Llopis, J; Orrenius, S | 1 |
| Grojec, MS; Ishac, EJ; Kapocsi, J; Kunos, G | 1 |
| Coezy, ED; Corvol, P; Howlett, AC | 1 |
| Griffiths, NM; Simmons, NL | 1 |
| Good, DW | 1 |
| Harano, Y; Hashimoto, T; Kashiwagi, A; Kojima, H; Shigeta, Y; Suzuki, M | 1 |
| Danoff, A; Fleischer, N; Pasmantier, R; Schubart, UK | 1 |
| Blackmore, PF; Exton, JH | 1 |
| Al-Turk, WA; Othman, S; Shaheen, O | 1 |
| Hara, M; Ogawa, A; Sasaki, H; Sato, N; Suda, K; Takahashi, K; Wada, K; Wakasugi, K; Yamatani, K | 1 |
| Kojima, I; Mine, T; Ogata, E | 1 |
| Boyd, AE; Hill, RS; Rajan, AS | 1 |
| Baxter, RC; Lewitt, MS | 1 |
| Chua, BH; Haneda, T; Morgan, HE; Watson, PA; Xenophontos, XP | 1 |
| Christoffersen, T; Johansen, EJ; Refsnes, M | 1 |
| Abramovitch, E; Cerasi, E; Nesher, R | 1 |
| Christoffersen, T; Gjone, IH; Gladhaug, IP; Ostby, E; Refsnes, M; Thoresen, GH | 1 |
| Katzir, Z; Popovtzer, MM; Rubinger, D; Wald, H | 1 |
| Blackmore, PF; Exton, JH; Johnson, EH; Krone, PK; Lynch, CJ; Wange, RL | 1 |
| Grapengiesser, E; Gylfe, E; Hellman, B | 1 |
| Hamm, MW; Lee, CR | 1 |
| Brubaker, PL; Drucker, DJ | 1 |
| Antoine, B; Decaux, JF; Kahn, A | 1 |
| Griffiths, NM; Rugg, EL; Simmons, NL | 1 |
| Gawler, DJ; Houslay, MD; Milligan, G; Wilson, A | 1 |
| Hermansen, K | 1 |
| Dettmer, D; Hermsdorf, T; Hofmann, E | 1 |
| Boland, SR; Hymer, TK; Katz, MS; McNair, CL | 1 |
| Amiel, C; Friedlander, G; Giocondi, MC; Le Grimellec, C | 1 |
| Ishikawa, S; Okada, K; Saito, T | 1 |
| Kurokawa, K; Takaichi, K | 2 |
| García-Sáinz, JA; Hernández-Sotomayor, SM; Macías-Silva, M; Plebañski, M | 1 |
| Hashimoto, K; Kato, K; Tsujimoto, A; Tsujimoto, G | 1 |
| Bianchini, L; Fossat, B; Guibbolini, M; Lahlou, B; Porthé-Nibelle, J | 1 |
| Davis, MS; Shuttleworth, TJ | 1 |
| Schonbrunn, A; Sullivan, SJ | 1 |
| Blackmore, PF; Bocckino, SB; Exton, JH; Waynick, LE | 1 |
| Bloom, AS; Hillard, CJ; Houslay, MD | 1 |
| Ho, RJ; Ruiz, J; Shi, QH | 1 |
| Hansford, RG; Staddon, JM | 1 |
| Bégin-Heick, N; Black, M; Heick, HM | 1 |
| Blackmore, PF; Bosch, F; Bouscarel, B; Exton, JH; Slaton, J | 1 |
| Dax, EM; Gregerman, RI; Partilla, JS; Piñeyro, MA | 1 |
| Hii, CS; Howell, SL | 2 |
| Hur, KC; Iwanij, V | 1 |
| Amiel, C; Friedlander, G | 1 |
| Ramanadham, S; Tenner, TE | 1 |
| Brelje, TC; Sorenson, RL | 1 |
| Söling, HD; Thiel, G | 1 |
| Anand-Srivastava, MB | 1 |
| Bannasch, P; Ehemann, V; Hacker, HJ; Mayer, D | 1 |
| Camus, JC; Christophe, J; De Neef, P; Gillard, M; Robberecht, P; Waelbroeck, M | 1 |
| Ho, RJ; Ruiz, JA | 1 |
| Ho, RJ; Ruiz, JA; Shi, QH | 1 |
| Dhillon, GS; Honnor, RC; Londos, C | 1 |
| Anand-Srivastava, MB; Srivastava, AK | 1 |
| Hynie, S; Klenerová, V; Wenke, M | 1 |
| Cook, DL; Ikeuchi, M | 1 |
| Corvera, S; García-Sáinz, JA; Hruby, VJ; Huerta-Bahena, J; Pelton, JT; Trivedi, D | 1 |
| Arslan, Y; Iynedjian, PB | 1 |
| Draznin, B; Leitner, JW; Steinberg, JP; Sussman, KE | 1 |
| Ho, R; Shi, QH | 1 |
| Exton, JH; Morgan, NG; Shipp, CC | 1 |
| Tarui, S | 1 |
| Ichihara, A; Kato, S; Nakamura, T; Noda, C; Shinjyo, F; Tomomura, A | 1 |
| Blum, JJ; Leiser, J | 1 |
| Jungermann, K; Zierz, S | 1 |
| Birnbaumer, L; Desmier, M; Hanoune, J; Stengel, D | 1 |
| Ogihara, M | 1 |
| Dégano, P; Fontela, T; García-Hermida, O; Marco, J; Salas, M; Silvestre, RA | 1 |
| Abrahamsen, N; Nishimura, E | 1 |
| Asa, SL; Brubaker, PL; Drucker, DJ; Jin, T; Young, TA | 1 |
| Absood, A; Maruno, K; Said, SI | 1 |
| Hinds, TR; Storm, DR; Wayman, GA | 1 |
| Alvaro, D; Bini, A; Capocaccia, L; Della Guardia, P; Furfaro, S; Gigliozzi, A; La Rosa, T; Piat, C | 1 |
| Drucker, DJ; Gajic, D | 1 |
| Göke, B; Göke, R; McGregor, GP | 1 |
| Kong, X; Lawrence, JC; Sevetson, BR | 1 |
| Bogoyevitch, MA; Fuller, SJ; Sugden, PH | 1 |
| Omiecinski, CJ; Sidhu, JS | 1 |
| Bokvist, K; Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Renström, E; Rorsman, P; Wulff, BS | 1 |
| Marubashi, S; Saito, K; Sasaki, H; Sato, N; Takahashi, K; Wakasugi, K; Yamatani, K | 1 |
| Bray, TM; Goss, PM; Nagy, LE; Rozwadowski, M; Stephen, LL | 1 |
| Fehmann, HC; Göke, B; Strowski, M | 1 |
| Arilla, E; Carrero, I; Couvineau, A; Guijarro, LG; Laburthe, M; Prieto, JC; Rodriguez-Henche, N | 1 |
| Chen, S; Stucki, JW; Ubl, JJ | 1 |
| Houslay, MD; Livingstone, C; MacDonald, C; Willett, B | 1 |
| Bushfield, M; Houslay, MD; Lavan, BE; Morris, NJ | 1 |
| Abello, J; Bernard, C; Bosshard, A; Chayvialle, JA; Cuber, JC; Ye, F | 1 |
| Cherkasova, TD; Iurkiv, VA | 1 |
| Classen, M; Dehne, K; Offermanns, S; Rosenthal, W; Schepp, W; Schmidtler, J | 1 |
| Meijer, DK; Merema, M; Nijholt, A; Smit, H; Steen, H | 1 |
| Cobbold, PH; Marrero, I; Sanchez-Bueno, A | 1 |
| Cortinovis, C; Klimek, F; Nogueira, E | 1 |
| Garcia-Jimenez, C; Hernandez, A; Obregon, MJ; Santisteban, P | 1 |
| Ramírez, I; Soley, M; Tebar, F | 1 |
| Brunner, HR; Grouzmann, E; Nicod, P; Thompson, N; Waeber, B; Waeber, G | 1 |
| Christoffersen, T; Jacobsen, FW; Refsnes, M; Sandnes, D | 1 |
| Bahouth, SW; Betts, D; Fain, JN; Kang, ES; Myers, LK | 1 |
| Kuestner, RE; Moore, EE; Stroop, SD; Thompson, DL | 1 |
| Buggy, JJ; Heurich, RO; Rossomando, AJ; Vandenberg, MT | 1 |
| Gordon, PB; Holen, I; Seglen, PO; Strømhaug, PE | 1 |
| Hanafusa, T; Kuwajima, M; Matsumura, T; Matsuzawa, Y; Miki, H; Mineo, I; Miyagawa, J; Nakajima, H; Namba, M; Nishimura, T | 1 |
| Laychock, SG | 1 |
| Göke, B; Göke, R; Steffen, H | 1 |
| Díaz-Laviada, I; Guillén, A; Haro, A; Nieto, JL | 1 |
| Fehmann, HC; Göke, B; Jiang, J; Pitt, D; Schweinfurth, J | 1 |
| Hernández, ML; Martínez, MJ; Ochoa, B; Ruiz, JI | 1 |
| Andreani-Mangeney, M; Bereziat, G; Girlich, D; Janvier, B; Vandenbrouck, Y | 1 |
| Dove, J; Matheny, M; Scarpace, PJ | 1 |
| Boissard, C; Chastre, E; Marie, JC; Phan, HH; Rosselin, G | 1 |
| Ding, WG; Gromada, J | 1 |
| Haneda, T; Kikuchi, K; Osaki, J; Sakai, H | 1 |
| Seidler, FJ; Slotkin, TA; Zeiders, JL | 1 |
| Christ, B; Jungermann, K; Nath, A | 1 |
| Leclercq-Meyer, V; Malaisse, WJ | 1 |
| Bouscarel, B; Ceryak, S; Fromm, H; Gettys, TW; Le, M; Matsuzaki, Y; Shoda, J | 1 |
| Ceppi, ED; Smith, FS; Titheradge, MA | 1 |
| Bokvist, K; Ding, WG; Gromada, J; Holst, JJ; Nielsen, JH; Rorsman, P | 1 |
| Hild, M; Schaller, H; Weber, O | 1 |
| Buchan, AM; Damholt, AB; Kofod, H | 1 |
| Nakata, M; Tanaka, H; Yada, T; Yaekura, K | 1 |
| Bannasch, P; Klimek, F; Mayer, D | 1 |
| Abello, J; Bosshard, A; Chayvialle, JA; Chevrier, AM; Cuber, JC; Saïfia, S | 1 |
| Bouscarel, B; Fromm, H; Gettys, TW; Le, M; Matsuzaki, Y | 1 |
| Bapty, BW; Canaff, L; Dai, LJ; Hendy, GN; Quamme, GA; Ritchie, G | 1 |
| Fehmann, HC; Göke, B; Pracht, A | 1 |
| Fukuzawa, J; Haneda, T; Kashiwagi, Y; Kikuchi, K; Oi, S; Osaki, J; Sakai, H | 1 |
| Chen, D; Håkanson, R; Lundquist, I; Nordin, G; Salehi, A | 1 |
| Bali, JP; Bataille, D; Geneviève, R; Jarrousse, C; Le Nguyen, D; Magous, R; Martinez, J; Mochizuki, T; Rodier, G | 1 |
| Fujioka, T; Ishibashi, K; Ui, M | 1 |
| Andreis, PG; Malendowicz, LK; Neri, G; Nussdorfer, GG; Tortorella, C | 1 |
| Belin, VD; Clayton, HA; Green, IC; James, RF; Mabley, JG; Swift, SM; Titheradge, MA | 1 |
| Ahrén, B; Havel, PJ | 1 |
| Anand-Srivastava, MB; Garcia, R; Ge, C | 2 |
| Ahrén, B; Karlsson, S; Simonsson, E | 1 |
| Bizeau, ME; Hazel, JR | 1 |
| Aust, G; Nguyen, TB; Scherbaum, WA; Seissler, J; Steinbrenner, H | 1 |
| Albertin, G; Aragona, F; Gottardo, L; Mazzocchi, G; Nussdorfer, GG | 1 |
| Anand-Srivastava, MB; Di Fusco, F; Hashim, S | 1 |
| Daniel, PB; Habener, JF; Hussain, MA | 1 |
| Bjurholm, A; Horton, MA; Lehenkari, PP; Lerner, UH; Lie, A; Lundberg, P; Ransjö, M | 1 |
| Niki, I; Nimura, Y; Niwa, T | 1 |
| Brubaker, PL; Dhanvantari, S; Izzo, A; Jansen, E | 1 |
| Manaka, H; Ohnuma, H; Saito, K; Sasaki, H; Takahashi, K; Yamatani, K | 1 |
| Chen, Q; Iber, H; Li-Masters, T; Morgan, ET; Yu, S | 1 |
| Cerasi, E; Efendic, S; Kaiser, N; Khan, A; Nesher, R; Warwar, N | 1 |
| Alm, P; Henningsson, R; Lundquist, I | 1 |
| Armatis, P; Csernus, B; Groot, K; Halmos, G; Plonowski, A; Rekasi, Z; Schally, AV; Varga, JL | 1 |
| Ganster, RW; Geller, DA; Harbrecht, BG; Ramalakshmi, S; Taylor, BS; Xu, Z | 1 |
| Lopez, M; Mazzeo, RS; Podolin, DA; Roth, DA; Wills, BK; Wood, IO | 1 |
| Bouscarel, B; Cypess, AM; Ikegami, T | 1 |
| Aizawa, T; Hashizume, K; Komatsu, M; Sato, Y; Yamada, S; Yamauchi, K | 1 |
| Bhatt, HS; Easom, RA; Lawrence, MC | 1 |
| Kirchgessner, AL; Ouedraogo, R; Tong, Q | 1 |
| Civelek, VN; Corkey, BE; Cunningham, BA; Daley, JT; Deeney, JT; Dillon, JS; Richard, AM; Tornheim, K; Yaney, GC | 1 |
| Aizawa, T; Hashizume, K; Kojima, I; Komatsu, M; Sato, Y; Yamada, S; Yamauchi, K | 1 |
| Drucker, DJ; Halban, PA; Hansotia, T; Li, Y; Ris, F; Yusta, B | 1 |
| da Silva Xavier, G; Holz, GG; Jouaville, LS; Rutter, GA; Thomas, AP; Tsuboi, T | 1 |
| Lee, JW; Romsos, DR; Swick, AG | 1 |
| Bojanowska, E; Stempniak, B | 1 |
| Abdel-Halim, SM; Ahrén, B; Efendic, S; Ljungberg, O; Lukinius, A; Portela-Gomes, GM | 1 |
| Canettieri, G; Jhala, US; Krajewski, S; Kulkarni, RN; Lin, X; Montminy, M; Reed, J; Screaton, RA; Walker, J; White, M | 1 |
| Julien, S; Lainé, J; Morisset, J | 1 |
| Göpel, SO; Holm, C; Olofsson, CS; Rorsman, P; Salehi, A | 1 |
| Ficarro, S; Grossman, LI; Hüttemann, M; Lee, I; Lottspeich, F; Mathes, I; Salomon, AR | 1 |
| Boer, P; Sperling, O | 1 |
| Liu, C; Shen, P; Zhang, C; Zhang, CY; Zhang, J; Zhang, P; Zhang, Y | 1 |
| Korol'kov, VI; Kuznetsova, LA; Pertseva, MN; Plesneva, SA; Shpakov, AO | 1 |
| Andrade, CF; Brubaker, PL; Chen, L; Dubé, PE; Jin, T; Liu, M; Wang, P; Zhao, IY | 1 |
| Becker, TC; Cao, W; Collins, QF; Collins, S; Daniel, KW; Floering, L; Lupo, EG; Robidoux, J; Xiong, Y | 1 |
| Farghali, H; Hodis, J; Kmoníčková, E; Kutinová-Canová, N; Potmesil, P; Zídek, Z | 1 |
| Amiel, SA; Brereton, H; Huang, GC; Jones, PM; Muller, DS; Persaud, SJ; Ramracheya, RD; Squires, PE; Sugden, D | 1 |
| Christ, B | 1 |
| Xie, X; Xu, Y | 1 |
| Abdulkader, F; Amisten, S; Bengtsson, M; Braha, O; Braun, M; De Marinis, YZ; Eliasson, L; Gribble, F; Habib, AM; Moritoh, Y; Ramracheya, R; Reimann, F; Renström, E; Rorsman, P; Rosengren, A; Salehi, A; Seino, S; Shibasaki, T; Ward, CE; Zhang, E; Zhang, Q | 1 |
| Alonge, KM; Cyphert, HA; Hillgartner, FB; Ippagunta, SM | 1 |
| Bertile, F; Chilloux, J; Delalande, F; Gautier-Stein, A; Mithieux, G; Soty, M; Zitoun, C | 1 |
| Edlund, A; Eliasson, L; Flodström-Tullberg, M; Lindqvist, A; Pedersen, MG; Wierup, N | 1 |
| Bosco, D; Dibner, C; Gachon, F; Giovannoni, L; Gobet, C; Gu, G; Heddad Masson, M; Petrenko, V; Philippe, J; Sage, D; Saini, C; Unser, M | 1 |
| Goldberg, AL; Lokireddy, S; VerPlank, JJS; Zhao, J | 1 |
| Ameneiro, C; Beiroa, D; Bernardo, G; Bilbao, J; Bravo, SB; Carneiro, C; Cho, JW; Coppari, R; Cuñarro, J; Da Silva Lima, N; Dieguez, C; Dp Chantada-Vazquez, M; Fernandez, U; Fernández-Ramos, D; Ferno, J; Fidalgo, M; Fondevila, MF; Fruhbeck, G; Garcia-Vence, M; Gonzalez-Rellan, MJ; Guallar, D; Herzig, S; Iglesias, C; López, M; Lopitz-Otsoa, F; Martinez-Chantar, ML; Mato, JM; Millet, O; Müller, TD; Nogueiras, R; Novoa, E; Perez-Fernandez, R; Porteiro, B; Rodríguez, A; Sabio, G; Senra, A; Seoane, S; Tovar, S; Varela-Rey, M; Veyrat-Durebex, C; Vidal, A; Woodhoo, A; Yang, WH | 1 |
214 other study(ies) available for glucagon and colforsin
| Article | Year |
|---|---|
Stimulation of angiotensinogen production in primary cultures of rat hepatocytes by glucocorticoid, cyclic adenosine 3',5'-monophosphate, and interleukin-6.
Topics: Angiotensinogen; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cytokines; Dexamethasone; DNA; DNA, Neoplasm; Dose-Response Relationship, Drug; Estrogens; Gene Expression; Glucagon; Glucocorticoids; Interleukin-6; Liver; Liver Neoplasms, Experimental; Male; Rats; Rats, Inbred Strains; Triiodothyronine; Tumor Cells, Cultured | 1992 |
Ion transport by primary cultures of Mongolian gerbil middle ear epithelium.
Topics: Amiloride; Animals; Arginine Vasopressin; Biological Transport; Bradykinin; Cell Membrane; Cell Membrane Permeability; Cells, Cultured; Chlorides; Colforsin; Cyclic AMP; Dinoprostone; Ear, Middle; Epithelium; Gerbillinae; Glucagon; Histamine; Indomethacin; Isoproterenol; Male; Mannitol; Microscopy, Electron; Parathyroid Hormone; Sodium | 1992 |
Rapid inverse changes in alpha 1B- and beta 2-adrenergic receptors and gene transcripts in acutely isolated rat liver cells.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cycloheximide; Glucagon; Inositol 1,4,5-Trisphosphate; Isoproterenol; Liver; Male; Phenylephrine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; RNA, Messenger; Time Factors; Transcription, Genetic | 1992 |
Modulation of cytosolic-[Ca2+] oscillations in hepatocytes results from cross-talk among second messengers. The synergism between the alpha 1-adrenergic response, glucagon and cyclic AMP, and their antagonism by insulin and diacylglycerol manifest themsel
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Benzimidazoles; Calcium; Calmodulin; Cations, Divalent; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Diglycerides; Drug Synergism; Glucagon; Imidazoles; Insulin; Liver; Phenylephrine; Protein Kinase C; Rats; Second Messenger Systems; Thionucleotides | 1992 |
Chronic ethanol consumption disturbs G-protein expression and inhibits cyclic AMP-dependent signaling in regenerating rat liver.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Cyclic AMP; Enzyme Activation; Ethanol; Gene Expression; Glucagon; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Liver; Liver Regeneration; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction | 1992 |
Control of proglucagon-derived peptide synthesis and secretion in fetal rat hypothalamus.
Topics: Animals; Bucladesine; Cells, Cultured; Colforsin; Enzyme Activation; Fetal Proteins; Glucagon; Hypothalamus; Neuropeptides; Proglucagon; Protein Kinase C; Protein Kinases; Protein Precursors; Radioimmunoassay; Rats; Tetradecanoylphorbol Acetate | 1992 |
Neuropeptides of the vasoactive intestinal peptide/helodermin/pituitary adenylate cyclase activating peptide family elevate plasma cAMP in mice: comparison with a range of other regulatory peptides.
Topics: Animals; Calcitonin; Calcitonin Gene-Related Peptide; Colforsin; Cyclic AMP; Drug Interactions; Glucagon; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Mice; Neuropeptides; Parathyroid Hormone; Peptides; Phosphodiesterase Inhibitors; Pyrrolidinones; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Rolipram; Tail; Vasoactive Intestinal Peptide | 1992 |
Ethanol increases receptor-dependent cyclic AMP production in cultured hepatocytes by decreasing G(i)-mediated inhibition.
Topics: Alcohol Dehydrogenase; Animals; Blotting, Western; Cells, Cultured; Colforsin; Cyclic AMP; Ethanol; Glucagon; GTP-Binding Proteins; Liver; Rats; Receptors, Purinergic; Somatostatin | 1992 |
Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3).
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Binding Sites; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Glucagon-Like Peptides; Insulinoma; Iodine Radioisotopes; Oxyntomodulin; Rats; Somatostatin; Tumor Cells, Cultured | 1992 |
Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells.
Topics: Adenylate Cyclase Toxin; Animals; Blotting, Northern; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Galanin; Gene Expression; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Mice; Models, Biological; Pancreatic Neoplasms; Peptide Fragments; Peptides; Pertussis Toxin; Proinsulin; RNA, Neoplasm; Transfection; Virulence Factors, Bordetella | 1992 |
Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones.
Topics: 1-Methyl-3-isobutylxanthine; Albumins; Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Epidermal Growth Factor; Fetus; Gene Expression Regulation; Glucagon; Liver; Norepinephrine; Phorbol Esters; Rats; Rats, Inbred Strains; RNA, Messenger; Signal Transduction; Time Factors; Vasopressins | 1992 |
Alterations in G-protein expression, Gi function and stimulatory receptor-mediated regulation of adipocyte adenylyl cyclase in a model of insulin-resistant diabetes with obesity.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Cell Membrane; Cells, Cultured; Colforsin; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucagon; GTP-Binding Proteins; Isoproterenol; Magnesium; Mice; Mice, Inbred CBA; Obesity; Secretin | 1992 |
Diabetes alters the responses of glucagon secreting cells and vascular bed to isoprenaline and forskolin in vitro in rat pancreas.
Topics: Adenylyl Cyclases; Animals; Blood Flow Velocity; Colforsin; Diabetes Mellitus, Experimental; Glucagon; Insulin; Isoproterenol; Kinetics; Male; Pancreas; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vasodilation | 1991 |
Regulation of islet somatostatin secretion and gene expression: selective effects of adenosine 3',5'-monophosphate and phorbol esters in normal islets of Langerhans and in a somatostatin-producing rat islet clonal cell line 1027 B2.
Topics: Adenoma, Islet Cell; Animals; Animals, Newborn; Bucladesine; Colforsin; Cyclic AMP; Gene Expression Regulation; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Phorbol Esters; Rats; Rats, Inbred Strains; RNA, Messenger; Somatostatin; Theophylline; Tumor Cells, Cultured | 1991 |
Antidiuretic hormone stimulation of adenylate cyclase in semicircular canal epithelium.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Calcitonin; Clonidine; Colforsin; Cyclic AMP; Dinoprostone; Endolymph; Epithelium; Glucagon; Isoproterenol; Norepinephrine; Organ Culture Techniques; Parathyroid Hormone; Rana esculenta; Semicircular Canals; Vasopressins; Vasotocin | 1991 |
Multiple hormone actions: the rises in cAMP and Ca++ in MDCK-cells treated with glucagon and prostaglandin E1 are independent processes.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Calcium; Carbachol; Cell Line; Colforsin; Cyclic AMP; Dogs; Fluorescent Dyes; Glucagon; Indoles; Isoproterenol; Kidney; Kinetics; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1990 |
Transcriptional repression of the mouse insulin-responsive glucose transporter (GLUT4) gene by cAMP.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipose Tissue; Animals; Antisense Elements (Genetics); Cell Line; Cell Nucleus; Colforsin; Cyclic AMP; Deoxyglucose; Glucagon; Isoproterenol; Kinetics; Mice; Monosaccharide Transport Proteins; RNA; Transcription, Genetic | 1991 |
Priming effect of glucagon-like peptide-1 (7-36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Sincalide | 1991 |
GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Biological Transport; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; In Vitro Techniques; Inositol Phosphates; Kinetics; Parietal Cells, Gastric; Peptide Fragments; Peptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1991 |
Hepatocanalicular organic-anion transport is regulated by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Anion Transport Proteins; Anions; Bile Canaliculi; Biological Transport; Bucladesine; Carrier Proteins; Colforsin; Cyclic AMP; Glucagon; Glutathione; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1991 |
Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Animals; Atenolol; Clenbuterol; Colforsin; Cyclic AMP; Glucagon; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1991 |
Adenylate cyclase activity in crude liver membranes during chemical hepatocarcinogenesis in portacaval shunted rats.
Topics: 2-Acetylaminofluorene; Adenylyl Cyclases; Animals; Cell Membrane; Colforsin; Diethylnitrosamine; Glucagon; Guanine Nucleotides; Liver; Liver Neoplasms, Experimental; Male; Portacaval Shunt, Surgical; Rats; Rats, Inbred Strains | 1992 |
Determination of G-protein levels, ADP-ribosylation by cholera and pertussis toxins and the regulation of adenylyl cyclase activity in liver plasma membranes from lean and genetically diabetic (db/db) mice.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Blotting, Western; Cell Membrane; Cholera Toxin; Colforsin; Diabetes Mellitus, Experimental; Glucagon; GTP-Binding Proteins; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Isoproterenol; Liver; Male; Mice; Mice, Inbred C57BL; Pertussis Toxin; Virulence Factors, Bordetella | 1991 |
Effect of glucagon or somatostatin on desensitized insulin secretion.
Topics: Animals; B-Lymphocytes; Colforsin; Glucagon; In Vitro Techniques; Insulin; Insulin Secretion; Male; Rats; Rats, Inbred Strains; Somatostatin; Time Factors | 1990 |
The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells.
Topics: Animals; Base Sequence; Cell Line; Cells, Cultured; Chromosome Deletion; Colforsin; Gene Expression Regulation; Glucagon; Glucose; Islets of Langerhans; Male; Molecular Sequence Data; Protein Kinase C; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic; Transfection | 1991 |
Potentiation of forskolin-induced increase of cAMP by diamide and N-ethylmaleimide in rat pancreatic islets.
Topics: Animals; Azo Compounds; Colforsin; Cyclic AMP; Diamide; Drug Synergism; Enzyme Induction; Ethylmaleimide; Glucagon; Islets of Langerhans; Rats | 1990 |
Flux through glycine cleavage system in isolated hepatocytes: effects of glucagon, cAMP, and calcium.
Topics: Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Glucagon; Glycine; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Theophylline | 1990 |
Hormonal regulation of glutathione efflux.
Topics: Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Glucagon; Glutathione; Hormones; Kinetics; Liver; Male; Methionine; Phenylephrine; Rats; Rats, Inbred Strains; Vasopressins | 1990 |
Receptor-operated calcium influx in rat hepatocytes. Identification and characterization using manganese.
Topics: Angiotensin II; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Fura-2; Glucagon; Hormones; Kinetics; Liver; Male; Manganese; Membrane Potentials; Nickel; Pertussis Toxin; Rats; Rats, Inbred Strains; Signal Transduction; Spectrometry, Fluorescence; Vasopressins; Virulence Factors, Bordetella | 1990 |
The effect of essential fatty acid deficiency on the adrenergic activation of glycogenolysis in rat hepatocytes.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Epinephrine; Fatty Acids, Essential; Fatty Acids, Unsaturated; Female; Glucagon; Isoproterenol; Kinetics; Liver; Liver Glycogen; Melitten; Phenylephrine; Phosphorylase a; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Adrenergic; Reference Values | 1990 |
Involvement of a pertussis toxin-sensitive G protein in the regulation of angiotensinogen production by an angiotensin II analog in HepG2 cells.
Topics: Adenosine Diphosphate Ribose; Angiotensin II; Angiotensinogen; Carcinoma, Hepatocellular; Colforsin; Cyclic AMP; Glucagon; GTP-Binding Proteins; Humans; Liver Neoplasms; Neoplasm Proteins; Pertussis Toxin; Protein Processing, Post-Translational; Second Messenger Systems; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1990 |
Vasoactive intestinal peptide stimulation of adenylate cyclase activity in isolated rabbit renal arterial microvessels.
Topics: Adenylyl Cyclases; Animals; Capillaries; Colforsin; Glucagon; In Vitro Techniques; Kidney; Male; Parathyroid Hormone; Prostaglandins E; Rabbits; Vasoactive Intestinal Peptide | 1990 |
Inhibition of bicarbonate absorption by peptide hormones and cyclic adenosine monophosphate in rat medullary thick ascending limb.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Absorption; Ammonia; Animals; Arginine Vasopressin; Bicarbonates; Biological Transport; Colforsin; Furosemide; Glucagon; In Vitro Techniques; Kidney Medulla; Kidney Tubules; Loop of Henle; Male; Parathyroid Hormone; Rats; Rats, Inbred Strains; Sodium Chloride | 1990 |
Phosphorylation of carnitine palmitoyltransferase and activation by glucagon in isolated rat hepatocytes.
Topics: Acyltransferases; Animals; Autoradiography; Carnitine O-Palmitoyltransferase; Colforsin; Diterpenes; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glucagon; Immunochemistry; In Vitro Techniques; Insulin; Ketone Bodies; Liver; Peptides; Phosphorylation; Rats; Staining and Labeling | 1985 |
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Animals; Colforsin; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glucagon; Insulinoma; Isoproterenol; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate | 1986 |
Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adrenergic alpha-Agonists; Aluminum; Aluminum Compounds; Angiotensin II; Calcium; Colforsin; Cyclic AMP; Drug Synergism; Fluorides; Glucagon; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Liver; Pertussis Toxin; Phorbols; Protein Kinase C; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thionucleotides; Vasopressins; Virulence Factors, Bordetella | 1986 |
Effect of forskolin on cAMP accumulation and ketogenesis in isolated hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Glucagon; Hypothyroidism; In Vitro Techniques; Ketone Bodies; Liver; Male; Rats | 1986 |
Two types of hormone-responsive adenylate cyclase in the rat liver.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Glucagon; Glucose; In Vitro Techniques; Insulin; Kinetics; Liver; Liver Glycogen; Male; Oxymetazoline; Perfusion; Rats; Rats, Inbred Strains; Secretin | 1987 |
Evidence of cyclic AMP-independent action of glucagon on calcium mobilization in rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Aequorin; Angiotensin II; Animals; Calcium; Colforsin; Cyclic AMP; Glucagon; Liver; Rats; Vasopressins | 1988 |
Effect of rise in cAMP levels on Ca2+ influx through voltage-dependent Ca2+ channels in HIT cells. Second-messenger synarchy in beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzofurans; Calcium; Calcium Channels; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; Electrophysiology; Fura-2; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Second Messenger Systems; Verapamil | 1989 |
Regulation of growth hormone-independent insulin-like growth factor-binding protein (BP-28) in cultured human fetal liver explants.
Topics: Amniotic Fluid; Carrier Proteins; Colforsin; Culture Techniques; Cycloheximide; Dexamethasone; Fetus; Glucagon; Glucose; Humans; Immunochemistry; Insulin; Insulin-Like Growth Factor Binding Proteins; Liver; Theophylline | 1989 |
Increased cyclic AMP content accelerates protein synthesis in rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbon Radioisotopes; Colforsin; Cyclic AMP; Glucagon; Heart; In Vitro Techniques; Insulin; Kinetics; Male; Myocardial Contraction; Myocardium; Perfusion; Phenylalanine; Protein Biosynthesis; Protein Kinases; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Tetrodotoxin; Theophylline | 1989 |
Glucagon-induced refractoriness of hepatocyte adenylate cyclase: comparison of homologous and heterologous components and evidence against a role of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Glucagon; Isoproterenol; Liver; Male; Rats; Rats, Inbred Strains | 1989 |
Reduced early and late phase insulin response to glucose in isolated spiny mouse (Acomys cahirinus) islets: a defective link between glycolysis and adenylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Female; Glucagon; Glucose; Glycolysis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Muridae; Rats; Rats, Inbred Strains | 1989 |
Studies of glucocorticoid enhancement of the capacity of hepatocytes to accumulate cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cycloheximide; Dexamethasone; Glucagon; Glucocorticoids; Isoproterenol; Kinetics; Liver; Male; Methylprednisolone; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains | 1989 |
Effect of heparin on cortical adenylate cyclase activity and on urinary excretion of 3',5'-adenosine monophosphate in rat.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dextran Sulfate; Dextrans; Glucagon; Heparin; Kidney Cortex; Magnesium; Parathyroid Hormone; Rats; Sodium Fluoride | 1989 |
Guanine nucleotide binding regulatory proteins and adenylate cyclase in livers of streptozotocin- and BB/Wor-diabetic rats. Immunodetection of Gs and Gi with antisera prepared against synthetic peptides.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Aluminum; Angiotensin II; Animals; Catalysis; Cell Line; Cell Membrane; Cholera Toxin; Colforsin; Diabetes Mellitus, Experimental; Enzyme Activation; Fluorine; Glucagon; GTP-Binding Proteins; Guanosine Triphosphate; Immune Sera; Injections, Intraperitoneal; Liver; Male; Peptide Fragments; Pertussis Toxin; Rats; Rats, Inbred BB; Rats, Inbred Strains; Virulence Factors, Bordetella | 1989 |
Three types of cytoplasmic Ca2+ oscillations in stimulated pancreatic beta-cells.
Topics: Adenosine Triphosphate; Animals; Benzofurans; Calcium; Carbachol; Colforsin; Cyclic AMP; Cytoplasm; Fura-2; Glucagon; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Mice; Mice, Obese; Rats; Theophylline | 1989 |
Effect of dietary fat and cholesterol supplements on glucagon receptor binding and adenylate cyclase activity of rat liver plasma membrane.
Topics: Adenylyl Cyclases; Animals; Cell Membrane; Cholesterol, Dietary; Colforsin; Corn Oil; Dietary Fats; Fish Oils; Glucagon; Liver; Male; Rats; Rats, Inbred Strains; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Sodium Fluoride | 1989 |
Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine.
Topics: Animals; Base Sequence; Bombesin; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP; DNA; Fetus; Gene Expression Regulation; Genes; Glucagon; Intestinal Mucosa; Kinetics; Molecular Sequence Data; Proglucagon; Protein Precursors; Rats; Rats, Inbred Strains; RNA, Messenger; Transcription, Genetic | 1989 |
Regulation of the expression of the L-type pyruvate kinase gene in adult rat hepatocytes in primary culture.
Topics: Animals; Blotting, Northern; Cells, Cultured; Colforsin; Cyclic AMP; Dactinomycin; Gene Expression Regulation; Glucagon; Glucose; Hormones; Insulin; Isoenzymes; Kinetics; Liver; Pyruvate Kinase; Rats; RNA, Messenger | 1989 |
Vasoactive intestinal peptide control of renal adenylate cyclase: in vitro studies of canine renal membranes and cultured canine renal epithelial (MDCK) cells.
Topics: Adenylyl Cyclases; Animals; Cell Line; Colforsin; Cyclic AMP; Dogs; Epithelial Cells; Epithelium; Glucagon; Kidney; Vasoactive Intestinal Peptide | 1989 |
Multiple defects occur in the guanine nucleotide regulatory protein system in liver plasma membranes of obese (fa/fa) but not lean (Fa/Fa) Zucker rats: loss of functional Gi and abnormal Gs function.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Blotting, Western; Cell Membrane; Cholera Toxin; Colforsin; Diabetes Mellitus, Experimental; Glucagon; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Insulin Resistance; Liver; Male; NAD; Obesity; Pertussis Toxin; Phosphorus Radioisotopes; Rats; Rats, Inbred Strains; Rats, Zucker; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Virulence Factors, Bordetella | 1989 |
Forskolin, an activator of adenylate cyclase, stimulates pancreatic insulin, glucagon, and somatostatin release in the dog: studies in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Atropine; Calcium; Colforsin; Diterpenes; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Pancreas; Phentolamine; Propranolol; Somatostatin | 1985 |
Age-dependent effects of phorbol ester on adenylate cyclase stimulation by glucagon in liver of female rats.
Topics: Adenylyl Cyclases; Animals; Colforsin; Female; Fetus; Glucagon; Guanylyl Imidodiphosphate; In Vitro Techniques; Isoproterenol; Kinetics; Liver; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1989 |
Emergence of beta adrenergic-responsive hepatic glycogenolysis in male rats during post-maturational aging.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Enzyme Activation; Epinephrine; Glucagon; Glucose; Glycogen; Isoproterenol; Liver; Male; Propranolol; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta | 1987 |
Benzyl alcohol increases membrane fluidity and modulates cyclic AMP synthesis in intact renal epithelial cells.
Topics: Animals; Benzyl Alcohol; Benzyl Alcohols; Benzyl Compounds; Cell Line; Colforsin; Cyclic AMP; Dinoprostone; Diphenylhexatriene; Epithelium; Fluorescence Polarization; Fluorescent Dyes; Glucagon; GTP-Binding Proteins; Indomethacin; Kidney; Manganese; Membrane Fluidity; Prostaglandins E; Vasopressins | 1987 |
Arginine vasopressin increases cellular free calcium concentration and adenosine 3',5'-monophosphate production in rat renal papillary collecting tubule cells in culture.
Topics: Animals; Arginine Vasopressin; Bucladesine; Calcium; Calcium Radioisotopes; Cells, Cultured; Colforsin; Cyclic AMP; Egtazic Acid; Glucagon; Kidney Tubules; Kidney Tubules, Collecting; Kinetics; Male; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1988 |
AVP-sensitive cAMP production is dependent on calmodulin in both MTAL and MCT.
Topics: Adenylyl Cyclases; Animals; Arginine Vasopressin; Calmodulin; Colforsin; Cyclic AMP; Enzyme Activation; Glucagon; Kidney Tubules; Kidney Tubules, Collecting; Loop of Henle; Mice; Sulfonamides; Trifluoperazine | 1988 |
Homologous and heterologous beta-adrenergic desensitization in hepatocytes. Additivity and effect of pertussis toxin.
Topics: Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Drug Interactions; Enzyme Activation; Female; Glucagon; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hypothyroidism; Isoproterenol; Liver; Pertussis Toxin; Propranolol; Protein Kinase C; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Tetradecanoylphorbol Acetate; Urea; Vasopressins; Virulence Factors, Bordetella | 1988 |
In vivo desensitization of glycogenolysis to Ca2+-mobilizing hormones in rat liver cells.
Topics: Adrenal Gland Neoplasms; Angiotensin II; Animals; Arginine Vasopressin; Bucladesine; Calcimycin; Calcium; Colforsin; Glucagon; Hormones; Liver Glycogen; Male; Norepinephrine; Phenoxybenzamine; Phenylephrine; Pheochromocytoma; Phosphorylases; Prazosin; Rats; Receptors, Adrenergic, alpha; Second Messenger Systems | 1988 |
Inhibitory effect of neurohypophysial peptides on cyclic AMP accumulation by isolated hepatocytes of the trout.
Topics: Animals; Colforsin; Cyclic AMP; Depression, Chemical; Dose-Response Relationship, Drug; Glucagon; Humans; In Vitro Techniques; Liver; Pituitary Hormones, Posterior; Salmonidae; Time Factors; Trout | 1988 |
Mode of adrenergic and peptidergic inhibition of ion transport in flounder gill.
Topics: Animals; Biological Transport; Colforsin; Cyclic AMP; Epinephrine; Epithelium; Flounder; Gills; Glucagon; Ions; Membrane Potentials; Somatostatin; Thionucleotides | 1986 |
Distribution of somatostatin receptors in RINm5F insulinoma cells.
Topics: Adenoma, Islet Cell; Animals; Cell Fractionation; Cell Membrane; Colforsin; Cytoplasmic Granules; Cytosol; Glucagon; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Iodine Radioisotopes; Kinetics; Leucine; Microsomes; Pancreatic Neoplasms; Rats; Receptors, Neurotransmitter; Receptors, Somatostatin; Somatostatin; Tumor Cells, Cultured | 1988 |
Role of a guanine nucleotide-binding regulatory protein in the hydrolysis of hepatocyte phosphatidylinositol 4,5-bisphosphate by calcium-mobilizing hormones and the control of cell calcium. Studies utilizing aluminum fluoride.
Topics: Aluminum; Aluminum Compounds; Animals; Calcium; Colforsin; Cyclic AMP; Enzyme Activation; Fluorides; Glucagon; Glycogen Synthase; GTP-Binding Proteins; Hydrolysis; In Vitro Techniques; Kinetics; Liver; Male; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphorylase a; Rats; Sodium Fluoride; Vasopressins | 1985 |
Effects of delta 9-tetrahydrocannabinol on glucagon receptor coupling to adenylate cyclase in rat liver plasma membranes.
Topics: Adenylyl Cyclases; Animals; Cannabinoids; Cell Membrane; Colforsin; Dronabinol; Glucagon; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Glucagon; Sodium Fluoride | 1986 |
A dose-response study of forskolin, stimulatory hormone, and guanosine triphosphate analog on adenylate cyclase from several sources.
Topics: Adenylyl Cyclases; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Cell Membrane; Colforsin; Drug Synergism; Enzyme Activation; Epinephrine; Erythrocyte Membrane; Glucagon; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Hormones; Liver; Rabbits; Rats; Solubility | 1986 |
4 beta-Phorbol 12-myristate 13-acetate attenuates the glucagon-induced increase in cytoplasmic free Ca2+ concentration in isolated rat hepatocytes.
Topics: Aminoquinolines; Animals; Bucladesine; Calcium; Colforsin; Fluorescent Dyes; Glucagon; In Vitro Techniques; Liver; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Abnormal regulation of insulin secretion in the genetically obese (ob/ob) mouse.
Topics: Animals; Calcium; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Obesity; Species Specificity | 1986 |
High Ca2+ inhibits peptide hormone-dependent cAMP production specifically in thick ascending limbs of Henle.
Topics: Animals; Arginine Vasopressin; Calcium; Colforsin; Cyclic AMP; Glucagon; Kidney Tubules; Kidney Tubules, Collecting; Loop of Henle; Male; Mice | 1986 |
Epidermal growth factor mimics insulin effects in rat hepatocytes.
Topics: Animals; Arginine Vasopressin; Calcium; Colforsin; Cyclic AMP; Enzyme Activation; Epidermal Growth Factor; Glucagon; Glycogen Synthase; Insulin; Liver; Male; Phenylephrine; Rats | 1986 |
Beta-adrenergic receptors, glucagon receptors, and their relationship to adenylate cyclase in rat liver during aging.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Enzyme Activation; Glucagon; Guanine Nucleotides; Guanylyl Imidodiphosphate; Isoproterenol; Liver; Male; Pindolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Sodium Fluoride | 1987 |
Role of second messengers in the regulation of glucagon secretion from isolated rat islets of Langerhans.
Topics: Animals; Arginine; Calcimycin; Calcium; Colforsin; Cyclic AMP; Diglycerides; Drug Interactions; Glucagon; Glycerides; Islets of Langerhans; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Trifluoperazine | 1987 |
Development of physiological responsiveness to glucagon during embryogenesis of avian heart.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Chick Embryo; Cholera Toxin; Colforsin; Glucagon; GTP-Binding Proteins; Heart; Myocardial Contraction; Receptors, Gastrointestinal Hormone; Receptors, Glucagon; Stimulation, Chemical; Time Factors | 1987 |
Protein kinase C activators and bradykinin selectively inhibit vasopressin-stimulated cAMP synthesis in MDCK cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bradykinin; Cell Line; Colforsin; Cyclic AMP; Diglycerides; Dinoprostone; Enzyme Activation; Glucagon; Isoquinolines; Piperazines; Prostaglandins E; Protein Kinase C; Tetradecanoylphorbol Acetate; Vasopressins | 1987 |
Alterations in the myocardial beta-adrenoceptor system of streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Calcium; Catecholamines; Colforsin; Diabetes Mellitus, Experimental; Electric Stimulation; Glucagon; Glycated Hemoglobin; In Vitro Techniques; Isoproterenol; Male; Methoxamine; Myocardial Contraction; Myocardium; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1987 |
Nutrient and hormonal regulation of the threshold of glucose-stimulated insulin secretion in isolated rat pancreases.
Topics: Animals; Carbachol; Colforsin; Fasting; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucose; Growth Hormone; Hormones; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Perfusion; Prolactin; Rats; Reference Values; Sincalide | 1988 |
cAMP-dependent protein phosphorylation of membrane proteins in the parotid gland, platelets and liver. Comparison of a 22-kDa phosphoprotein from rat parotid microsomes (protein III) with phosphoproteins of similar molecular size from platelet and liver m
Topics: Animals; Blood Platelets; Colforsin; Electrophoresis, Polyacrylamide Gel; Glucagon; Liver; Male; Membrane Proteins; Microsomes, Liver; Molecular Weight; Parotid Gland; Phosphorylation; Protein Kinases; Rats; Rats, Inbred Strains | 1988 |
Altered responsiveness of adenylate cyclase to adenosine and other agents in the myocardial sarcolemma and aorta of spontaneously-hypertensive rats.
Topics: Adenosine; Adenylyl Cyclases; Animals; Aorta; Colforsin; Epinephrine; Female; Glucagon; Hypertension; In Vitro Techniques; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sarcolemma | 1988 |
Restoration of the A cell response to glucose in isolated rat islets of Langerhans.
Topics: Animals; Arginine; Colforsin; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1986 |
Loss of adenylate cyclase activity in preneoplastic and neoplastic lesions induced in rat liver by N-nitrosomorpholine.
Topics: Adenylyl Cyclase Inhibitors; Animals; Cholera Toxin; Colforsin; Glucagon; Glucosephosphate Dehydrogenase; Liver; Liver Neoplasms; Male; Microscopy, Electron; Nitrosamines; Precancerous Conditions; Rats; Rats, Inbred Strains | 1986 |
Alterations of rat cardiac adenylate cyclase activity with age.
Topics: Adenylyl Cyclases; Aging; Animals; Colforsin; Glucagon; Guanylyl Imidodiphosphate; Isoproterenol; Male; Myocardium; Rats; Rats, Inbred Strains; Secretin; Sodium Fluoride | 1986 |
Preparation of rat liver plasma membrane with respect to glucagon-sensitive adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Cell Fractionation; Cell Membrane; Colforsin; Enzyme Activation; Glucagon; Guanylyl Imidodiphosphate; Liver; Male; Rats; Rats, Inbred Strains | 1986 |
Forms of adenylate cyclase, activation and/or potentiation by forskolin.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Binding Sites; Cell Membrane; Chromatography, Affinity; Colforsin; Drug Synergism; Enzyme Activation; Epinephrine; Glucagon; Guanylyl Imidodiphosphate; Liver; Rats | 1986 |
cAMP-dependent protein kinase and lipolysis in rat adipocytes. II. Definition of steady-state relationship with lipolytic and antilipolytic modulators.
Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Adipose Tissue; Animals; Colforsin; Cosyntropin; Deoxyadenosines; Dideoxyadenosine; Enzyme Activation; Glucagon; Glycerol; Isoproterenol; Kinetics; Lipolysis; Male; Phenylisopropyladenosine; Protein Kinases; Rats; Rats, Inbred Strains; Time Factors | 1985 |
Streptozotocin-induced diabetes and hormone sensitivity of adenylate cyclase in rat myocardial sarcolemma, aorta and liver.
Topics: Adenylyl Cyclases; Animals; Aorta; Catecholamines; Colforsin; Corpus Striatum; Diabetes Mellitus, Experimental; Diterpenes; Glucagon; Guanosine Triphosphate; Hormones; Liver; Male; Myocardium; Rats; Rats, Inbred Strains; Sarcolemma | 1985 |
Inhibitory effects of pentacaine and some related local anaesthetics on rat hepatic adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; Anesthetics, Local; Animals; Carbamates; Colforsin; Glucagon; Glucosides; Guanylyl Imidodiphosphate; Liver; Piperidines; Rats; Structure-Activity Relationship | 1985 |
Glucagon and forskolin have dual effects upon islet cell electrical activity.
Topics: Action Potentials; Animals; Calcium; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Electrophysiology; Female; Glucagon; Glucose; Islets of Langerhans; Mice; Time Factors | 1984 |
Metabolic effects and cyclic AMP levels produced by glucagon, (1-N alpha-Trinitrophenylhistidine,12-homoarginine)glucagon and forskolin in isolated rat hepatocytes.
Topics: Animals; Calcium; Colforsin; Cyclic AMP; Diterpenes; Glucagon; Gluconeogenesis; Glycogen; Liver; Rats; Urea | 1984 |
Phosphorylation of histones and non-histone nuclear proteins in liver cells stimulated by glucagon and cyclic AMP.
Topics: Animals; Cell-Free System; Chromosomal Proteins, Non-Histone; Colforsin; Cyclic AMP; Diterpenes; Electrophoresis, Polyacrylamide Gel; Glucagon; Histones; Liver; Molecular Weight; Phosphorylation; Rats | 1984 |
Calmodulin and cyclic AMP. Possible different sites of action of these two regulatory agents in exocytotic hormone release.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calmodulin; Colforsin; Cyclic AMP; Diterpenes; Exocytosis; Glucagon; Glucose; Hormones; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Somatostatin; Somatostatin | 1984 |
Forskolin as a novel lipolytic agent.
Topics: Adenylyl Cyclases; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Cell Membrane; Colforsin; Cyclic AMP; Diterpenes; Drug Synergism; Epinephrine; Fatty Acids, Nonesterified; Glucagon; Guanylyl Imidodiphosphate; In Vitro Techniques; Kinetics; Lipolysis; Male; Rats; Sodium Fluoride | 1982 |
Studies on the mechanism of inhibition of hepatic cAMP accumulation by vasopressin.
Topics: Adenylyl Cyclases; Animals; Calcium; Calmodulin; Chlorpromazine; Colforsin; Cyclic AMP; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Glucagon; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Trifluoperazine; Vasopressins | 1983 |
[Forskolin, cyclic AMP and hormone regulation].
Topics: Adrenal Glands; Animals; Cell Membrane Permeability; Colforsin; Corticosterone; Cyclic AMP; Deoxyglucose; Diabetes Mellitus, Experimental; Diterpenes; Glucagon; In Vitro Techniques; Liver; Phosphofructokinase-1; Phosphotransferases; Rats | 1983 |
Mechanism of heterologous desensitization of the adenylate cyclase system by glucagon in primary cultures of adult rat hepatocytes.
Topics: Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Diterpenes; Glucagon; Guanylyl Imidodiphosphate; Iodocyanopindolol; Isoproterenol; Liver; Male; Pindolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Sodium Fluoride | 1984 |
Effects of VIP and forskolin on alanine metabolism in isolated hepatocytes.
Topics: Alanine; Animals; Colforsin; Diterpenes; Fasting; Glucagon; Gluconeogenesis; In Vitro Techniques; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Urea; Vasoactive Intestinal Peptide | 1984 |
Alteration with dietary state of the activity and zonal distribution of adenylate cyclase stimulated by glucagon, fluoride and forskolin in microdissected rat liver tissue.
Topics: Adenylyl Cyclases; Animals; Colforsin; Diet; Dissection; Diterpenes; Fasting; Fluorides; Glucagon; Histocytochemistry; Liver; Male; Rats; Rats, Inbred Strains | 1984 |
Forskolin regulation of liver membrane adenylyl cyclase.
Topics: Adenosine Triphosphate; Adenylyl Cyclases; Animals; Cell Membrane; Chemical Phenomena; Chemistry; Colforsin; Diterpenes; Enzyme Activation; Glucagon; Guanosine Triphosphate; Guanylyl Imidodiphosphate; Liver; Rats; Sodium Fluoride | 1983 |
Expression of alpha 2-receptor-mediated responses by insulin in primary culture of rat hepatocytes.
Topics: Animals; Cells, Cultured; Clonidine; Colforsin; Cyclic AMP; Cycloheximide; Drug Interactions; Glucagon; Glucose; Insulin; Liver; Male; Oxymetazoline; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Time Factors | 1995 |
Amylin (islet amyloid polypeptide) inhibition of insulin release in the perfused rat pancreas: implication of the adenylate cyclase/cAMP system.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Amyloid; Animals; Colforsin; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Insulin Secretion; Islet Amyloid Polypeptide; Islets of Langerhans; Male; Perfusion; Rats; Rats, Wistar | 1994 |
Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Ribonucleases; RNA, Messenger | 1995 |
Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Polyomavirus Transforming; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Intestinal Neoplasms; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Electron; Neoplasm Transplantation; Peptide Fragments; Proglucagon; Protein Precursors; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Carbazoles; Cell Cycle; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Dose-Response Relationship, Drug; Glucagon; Histamine; Histamine Antagonists; Humans; Indoles; Kinetics; Muscle, Smooth; Pyrroles; Thymidine; Trachea; Vasoactive Intestinal Peptide | 1995 |
Hormone stimulation of type III adenylyl cyclase induces Ca2+ oscillations in HEK-293 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Humans; Inositol 1,4,5-Trisphosphate Receptors; Isoproterenol; Isoquinolines; Kidney; Kinetics; Models, Biological; Oscillometry; Phosphatidylinositols; Piperazines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucagon; Signal Transduction; Time Factors | 1995 |
Effect of glucagon on intracellular pH regulation in isolated rat hepatocyte couplets.
Topics: Animals; Antiporters; Bicarbonates; Bile; Bucladesine; Cells, Cultured; Chloride-Bicarbonate Antiporters; Chlorides; Cholagogues and Choleretics; Colchicine; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Glucagon; Hydrogen-Ion Concentration; Intracellular Fluid; Isoquinolines; Liver; Male; Nitrobenzoates; Rats; Rats, Wistar; Sodium; Sodium-Hydrogen Exchangers; Sulfonamides; Tetradecanoylphorbol Acetate; Thionucleotides | 1995 |
Multiple cis-acting domains mediate basal and adenosine 3',5'-monophosphate-dependent glucagon gene transcription in a mouse neuroendocrine cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; Glucagon; Intestinal Neoplasms; Mice; Mice, Transgenic; Neurosecretory Systems; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Amylin alters the biological action of the incretin hormone GLP-1(7-36)amide.
Topics: Adenylyl Cyclases; Amyloid; Animals; Cell Line; Colforsin; Cyclic AMP; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose Intolerance; Insulinoma; Islet Amyloid Polypeptide; Islets of Langerhans; Models, Biological; Peptide Fragments; Peptides; Rats; Substance P | 1993 |
Increasing cAMP attenuates activation of mitogen-activated protein kinase.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipocytes; Animals; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Epididymis; Glucagon; Isoenzymes; Isoproterenol; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Phosphoproteins; Phosphotyrosine; Rats; Rats, Sprague-Dawley; Thionucleotides; Tyrosine | 1993 |
cAMP and protein synthesis in isolated adult rat heart preparations.
Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Energy Metabolism; Epinephrine; Glucagon; Heart; Hypertension; In Vitro Techniques; Isoproterenol; Kinetics; Male; Myocardium; Perfusion; Phenylephrine; Phosphocreatine; Prazosin; Propranolol; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Yohimbine | 1993 |
cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures.
Topics: Albumins; Animals; Aryl Hydrocarbon Hydroxylases; Base Sequence; Benzoflavones; beta-Naphthoflavone; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dexamethasone; Dichlororibofuranosylbenzimidazole; Dose-Response Relationship, Drug; Enzyme Induction; Gene Expression Regulation, Enzymologic; Glucagon; Liver; Mixed Function Oxygenases; Molecular Sequence Data; Phenobarbital; Phosphodiesterase Inhibitors; Rats; Stereoisomerism; Steroid Hydroxylases; Thionucleotides; Transcriptional Activation | 1995 |
Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Colforsin; Cyclic AMP; Cytoplasm; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Inositol Phosphates; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Pancreatic Neoplasms; Peptide Fragments; Ryanodine; Time Factors; Tumor Cells, Cultured | 1995 |
Catecholamine-induced cAMP response in streptozotocin-induced diabetic rat liver.
Topics: Adipose Tissue; Animals; Colforsin; Cyclic AMP; Diabetes Mellitus, Experimental; Emaciation; Epinephrine; Glucagon; Glucose; Insulin; Isoproterenol; Lactates; Lactic Acid; Liver; Male; Oxymetazoline; Phenylephrine; Propranolol; Pyruvates; Pyruvic Acid; Rats; Receptors, Adrenergic, beta; Streptozocin | 1994 |
Activity of cAMP-dependent protein kinase is reduced in protein-energy malnourished rats.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Dietary Proteins; Glucagon; Glutathione; Guanine Nucleotides; Liver; Male; Manganese; Protein Kinases; Protein-Energy Malnutrition; Rats; Rats, Wistar; Receptors, Glucagon; Signal Transduction | 1995 |
Interaction of glucagon-like peptide-I (7-37) and somatostatin-14 on signal transduction and proinsulin gene expression in beta TC-1 cells.
Topics: Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Drug Interactions; Gene Expression; Glucagon-Like Peptide-1 Receptor; Glucagon-Like Peptides; Insulinoma; Mice; Pancreatic Neoplasms; Peptides; Proinsulin; Receptors, Cell Surface; Receptors, Glucagon; Signal Transduction; Somatostatin; Tumor Cells, Cultured | 1994 |
G proteins in rat liver proliferation during cholestasis.
Topics: Adenosine Diphosphate; Adenylate Cyclase Toxin; Adenylyl Cyclases; Animals; Bile Ducts; Cell Division; Cell Membrane; Cholera Toxin; Cholestasis; Colforsin; Glucagon; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Ligation; Liver; Male; Peptide Fragments; Pertussis Toxin; Rats; Rats, Wistar; Vasoactive Intestinal Peptide; Virulence Factors, Bordetella | 1994 |
Anti-diabetic biguanides inhibit hormone-induced intracellular Ca2+ concentration oscillations in rat hepatocytes.
Topics: Animals; Biguanides; Bucladesine; Calcium; Chlorides; Colforsin; Cyclic AMP; Glucagon; Inositol 1,4,5-Trisphosphate; Insulin; Liver; Male; Manganese Compounds; Metformin; Phenformin; Phenylephrine; Rats; Rats, Wistar; Second Messenger Systems | 1994 |
Analysis of the adenylate cyclase signalling system, and alterations induced by culture with insulin, in a novel SV40-DNA-immortalized hepatocyte cell line (P9 cells).
Topics: Adenosine Diphosphate Ribose; Adenylyl Cyclases; Alprostadil; Animals; Cell Line; Cell Transformation, Viral; Colforsin; Glucagon; GTP-Binding Proteins; Guanosine Triphosphate; Insulin; Liver; Male; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction | 1994 |
Multi-site phosphorylation of the inhibitory guanine nucleotide regulatory protein Gi-2 occurs in intact rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amino Acid Sequence; Animals; Binding Sites; Colforsin; Glucagon; GTP-Binding Proteins; Immunosorbent Techniques; Isoelectric Point; Liver; Male; Molecular Sequence Data; Peptide Fragments; Phosphorylation; Phosphoserine; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Tetradecanoylphorbol Acetate; Trypsin; Vasopressins | 1994 |
Stimulation of glucagon-like peptide-1 secretion by muscarinic agonist in a murine intestinal endocrine cell line.
Topics: Calcium; Carbachol; Cell Line; Colforsin; Cyclic AMP; Endocrine Glands; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Intestines; Kinetics; Muscarinic Antagonists; N-Methylscopolamine; Parasympathomimetics; Peptide Fragments; Protein Precursors; Receptors, Muscarinic; Scopolamine Derivatives; Tetradecanoylphorbol Acetate | 1994 |
[Hormonal regulation of carbohydrate metabolism in the liver in plague intoxication].
Topics: Adenylyl Cyclases; Animals; Bacterial Toxins; Blood Glucose; Carbohydrate Metabolism; Colforsin; Cyclic AMP; Enzyme Activation; Fluorides; Glucagon; Guanylyl Imidodiphosphate; Isoproterenol; Liver; Liver Glycogen; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Yersinia pestis | 1994 |
Stimulation of rat parietal cell function by histamine and GLP-1-(7-36) amide is mediated by Gs alpha.
Topics: Adenosine Diphosphate; Adenylyl Cyclases; Aminopyrine; Animals; Cell Membrane; Cell Separation; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Female; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; GTP-Binding Proteins; Histamine; Kinetics; Molecular Weight; Parietal Cells, Gastric; Peptide Fragments; Rats; Rats, Wistar | 1994 |
Modulators of the protein kinase C system influence biliary excretion of cationic drugs.
Topics: Alkaloids; Animals; Bile; Biological Transport, Active; Carrier Proteins; Cations; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Glucagon; In Vitro Techniques; Liver; Male; Perfusion; Protein Kinase C; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1993 |
Different modulatory effects of elevated cyclic AMP on cytosolic Ca2+ spikes induced by phenylephrine or vasopressin in single rat hepatocytes.
Topics: Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Cytosol; Glucagon; Liver; Male; Phenylephrine; Rats; Rats, Wistar; Vasopressins | 1993 |
Adenylate cyclase activity in microdissected rat liver tissue: periportal to pericentral activity gradient.
Topics: Adenylyl Cyclases; Angiotensin II; Animals; Chlorides; Cholera Toxin; Colforsin; Cyclic AMP; Glucagon; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Isoproterenol; Lithium; Lithium Chloride; Liver; Male; Rats; Rats, Sprague-Dawley; Sodium Fluoride | 1993 |
Regulation of malic-enzyme-gene expression by cAMP and retinoic acid in differentiating brown adipocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Colforsin; Cyclic AMP; Gene Expression Regulation, Enzymologic; Glucagon; Insulin; Malate Dehydrogenase; Norepinephrine; Rats; RNA, Messenger; Tretinoin; Triiodothyronine | 1993 |
Epidermal growth factor modulates the lipolytic action of catecholamines in rat adipocytes. Involvement of a Gi protein.
Topics: Adenosine; Adenosine Deaminase; Adipose Tissue; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Epidermal Growth Factor; Glucagon; GTP-Binding Proteins; Isoproterenol; Lipolysis; Male; Rats; Rats, Wistar; Signal Transduction | 1993 |
Neuropeptide Y expression and regulation in a differentiated rat insulin-secreting cell line.
Topics: Adenylyl Cyclases; Animals; Cell Differentiation; Clonidine; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulin Secretion; Insulinoma; Neuropeptide Y; Pancreatic Neoplasms; Peptide Fragments; Protein Kinase C; Rats; Receptors, Neuropeptide Y; Tumor Cells, Cultured | 1993 |
Long-term inhibitory effect of cAMP on beta-adrenoceptor acquisition and nonselective attenuation of adenylyl cyclase in hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Down-Regulation; Glucagon; Iodocyanopindolol; Isoproterenol; Liver; Male; Pindolol; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Thionucleotides | 1993 |
Chronic exposure of rat fat cells to insulin enhances lipolysis and activation of partially purified hormone-sensitive lipase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipose Tissue; Adrenocorticotropic Hormone; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Glucagon; Growth Hormone; Imidazoles; Insulin; Isoproterenol; Lipase; Lipolysis; Male; Norepinephrine; Phosphorylation; Rats; Rats, Sprague-Dawley; Thyrotropin | 1993 |
A recombinant human calcitonin receptor functions as an extracellular calcium sensor.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcitonin; Calcium; Cell Line; Cell Membrane; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; Cytosol; Glucagon; Humans; Kidney; Kinetics; Receptors, Calcitonin; Receptors, Cell Surface; Recombinant Proteins; Time Factors; Transfection | 1993 |
Inhibition of protein kinase A-induced glucagon synthesis and secretion by glucose.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Citrates; Citric Acid; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucose; Male; Rats; Streptozocin | 1996 |
Glucagon induces a rapid and sustained phosphorylation of the human glucagon receptor in Chinese hamster ovary cells.
Topics: Amino Acid Sequence; Animals; Antibodies; CHO Cells; Colforsin; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Glucagon; Humans; Kinetics; Molecular Sequence Data; Peptide Fragments; Phosphates; Phosphoproteins; Phosphorylation; Phosphoserine; Protein Kinase C; Receptors, Glucagon; Recombinant Proteins; Tetradecanoylphorbol Acetate; Transfection | 1996 |
Role of cAMP in the regulation of hepatocytic autophagy.
Topics: Animals; Autophagy; Bucladesine; Cell Survival; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucagon; Liver; Male; Protein Kinase Inhibitors; Proteins; Rats; Rats, Wistar | 1996 |
Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Animals; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Glucose; Insulin; Male; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Rats | 1996 |
Impaired cyclic AMP response to stimuli in glucose-desensitized rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Drug Tolerance; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 1995 |
The signal transduction of the glucagon-like peptide 1 receptor: fishing beyond the protein kinase level.
Topics: Colforsin; Electrophoresis, Gel, Two-Dimensional; Glucagon; Glucagon-Like Peptide 1; Insulinoma; Isoelectric Focusing; Molecular Weight; Peptide Fragments; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Precursors; Receptors, Glucagon; Signal Transduction; Tumor Cells, Cultured | 1996 |
Effect of endurance physical training on rat liver adenylyl cyclase system.
Topics: Adaptation, Physiological; Adenylyl Cyclases; Adrenergic beta-Antagonists; Animals; Colforsin; Enzyme Activation; Fluorides; Glucagon; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Isoproterenol; Liver; Male; Manganese; Physical Conditioning, Animal; Physical Endurance; Pindolol; Random Allocation; Rats; Rats, Wistar; Receptors, Adrenergic, beta | 1996 |
Ligand-induced regulation of glucagon-like peptide-I receptor function and expression in insulin-secreting beta cells.
Topics: Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Tumor Cells, Cultured | 1996 |
Stimulation of microsomal cholesterol ester hydrolase by glucagon, cyclic AMP analogues, and vasopressin in isolated rat hepatocytes.
Topics: Animals; Bucladesine; Cholesterol Esters; Colforsin; Cyclic AMP; Diglycerides; Glucagon; Microsomes, Liver; Particle Size; Prazosin; Rats; Sterol Esterase; Thionucleotides; Vasopressins | 1996 |
Transcriptional regulation of apolipoprotein E expression by cyclic AMP.
Topics: Apolipoproteins E; Bucladesine; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation; Glucagon; Humans; Promoter Regions, Genetic; RNA, Messenger; Transfection; Tumor Cells, Cultured | 1996 |
Effects of age on beta adrenergic subtype activation of adenylyl cyclase in brown adipose tissue.
Topics: Adenylyl Cyclases; Adipose Tissue, Brown; Adrenergic beta-Agonists; Age Factors; Animals; Colforsin; Dose-Response Relationship, Drug; Enzyme Activation; Ethanolamines; Gene Expression; Glucagon; Isoproterenol; Kinetics; Male; Rats; Rats, Inbred F344; Receptors, Adrenergic, beta; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-3; Regression Analysis; RNA, Messenger; Sodium Fluoride | 1996 |
Effect of PACAP, VIP, glucagon, and GLP1 on cAMP production and insulin release of HIT-T15 cells is passage dependent.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Line, Transformed; Colforsin; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Swine; Vasoactive Intestinal Peptide | 1996 |
Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucose-dependent insulinotropic polypeptide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Exocytosis; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Peptide Fragments; Phosphodiesterase Inhibitors; Tetradecanoylphorbol Acetate; Thionucleotides | 1997 |
cAMP-mediated c-fos expression in pressure-overloaded acceleration of protein synthesis in adult rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Genes, fos; Glucagon; Isoquinolines; Male; Perfusion; Phosphodiesterase Inhibitors; Pressure; Protein Biosynthesis; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Age Factors; Animals; Animals, Newborn; Body Weight; Carbachol; Cell Membrane; Colforsin; Drug Hypersensitivity; Female; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; Guanosine Triphosphate; Heart; Isoproterenol; Male; Manganese; Membrane Proteins; Muscarinic Agonists; Myocardium; Pregnancy; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Time Factors | 1997 |
Mechanism of the impairment of the glucagon-stimulated phosphoenolpyruvate carboxykinase gene expression by interleukin-6 in rat hepatocytes: inhibition of the increase in cyclic 3',5' adenosine monophosphate and the downstream cyclic 3',5' adenosine mono
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Gene Expression Regulation, Enzymologic; Genes, Reporter; Glucagon; Interleukin-6; Liver; Male; Pertussis Toxin; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transfection; Virulence Factors, Bordetella | 1997 |
Modulation of gliquidone action by forskolin in the pancreas of normal and GK rats.
Topics: Animals; Blood Glucose; Colforsin; Diabetes Mellitus, Type 2; Glucagon; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Perfusion; Rats; Rats, Inbred Strains; Rats, Wistar; Reference Values; Sulfonylurea Compounds; Time Factors | 1997 |
Effect of cholestasis on regulation of cAMP synthesis by glucagon and bile acids in isolated hepatocytes.
Topics: Angiotensin II; Animals; Bile; Bile Acids and Salts; Cells, Cultured; Cholestasis; Colforsin; Common Bile Duct; Cricetinae; Cyclic AMP; Glucagon; Isoenzymes; Kinetics; Liver; Male; Mesocricetus; Protein Kinase C; Protein Kinase C-alpha; Receptors, Glucagon; Reference Values; Taurocholic Acid; Ursodeoxycholic Acid | 1997 |
Inhibition of cytokine-induced inducible nitric oxide synthase expression by glucagon and cAMP in cultured hepatocytes.
Topics: Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Activation; Enzyme Induction; Glucagon; Lipopolysaccharides; Liver; Male; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Time Factors | 1997 |
Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling.
Topics: Adult; Calcium; Calcium Channels; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Exocytosis; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Humans; Islets of Langerhans; Male; Membrane Potentials; Middle Aged; Neurotransmitter Agents; Peptide Fragments; Potassium Channels; Somatostatin | 1998 |
Glucagon treatment interferes with an early step of duck hepatitis B virus infection.
Topics: Animals; Antiviral Agents; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Disease Susceptibility; DNA, Circular; Ducks; Gene Amplification; Glucagon; Hepadnaviridae Infections; Hepatitis B Virus, Duck; Intracellular Fluid; Time Factors; Virus Replication | 1998 |
Glucagon-like-peptide-1 secretion from canine L-cells is increased by glucose-dependent-insulinotropic peptide but unaffected by glucose.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dogs; Enteroendocrine Cells; Enzyme Activation; Enzyme Inhibitors; Female; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucose; Immunohistochemistry; Isoquinolines; Male; Peptide Fragments; Protein Kinase C; Protein Precursors; Somatostatin; Tetradecanoylphorbol Acetate | 1998 |
Cyclic AMP, a mediator of GLP-1, acts in concert with glucose and tolbutamide to increase cytosolic Ca2+ in pancreatic B-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islets of Langerhans; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide | 1997 |
Cytochemical and biochemical studies on adenylate cyclase activity in preneoplastic and neoplastic liver tissue and cultured liver cells.
Topics: Adenosine Triphosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Carcinogens; Cell Line; Cell Transformation, Neoplastic; Cholera Toxin; Colforsin; Enzyme Activation; Glucagon; Liver; Liver Neoplasms, Experimental; Male; Microscopy, Electron; Microscopy, Phase-Contrast; Nitrosamines; Precancerous Conditions; Rats; Rats, Sprague-Dawley; Substrate Specificity; Time Factors | 1998 |
Galanin inhibits glucagon-like peptide-1 secretion through pertussis toxin-sensitive G protein and ATP-dependent potassium channels in rat ileal L-cells.
Topics: Animals; Bombesin; Cells, Cultured; Colforsin; Disopyramide; Dose-Response Relationship, Drug; Galanin; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; GTP-Binding Proteins; Ileum; Immunohistochemistry; Male; Microscopy, Fluorescence; Peptide Fragments; Pertussis Toxin; Potassium Channels; Protein Precursors; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1998 |
Changes in G protein expression account for impaired modulation of hepatic cAMP formation after BDL.
Topics: Angiotensin II; Animals; Cholestasis; Colforsin; Common Bile Duct; Cricetinae; Cyclic AMP; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; Keratins; Ligation; Liver; Male; Mesocricetus; Receptors, Glucagon; Taurochenodeoxycholic Acid; Ursodeoxycholic Acid | 1998 |
Mg2+/Ca2+ sensing inhibits hormone-stimulated Mg2+ uptake in mouse distal convoluted tubule cells.
Topics: Amiloride; Animals; Arginine Vasopressin; Calcium; Cations, Divalent; Cell Line, Transformed; Colforsin; Culture Media; Cyclic AMP; Glucagon; Kidney Tubules, Distal; Kinetics; Magnesium; Mice; Neomycin; Protein Synthesis Inhibitors | 1998 |
High-level expression of the GLP-I receptor results in receptor desensitization.
Topics: Animals; Cells, Cultured; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Peptide Fragments; Protein Precursors; Receptors, Glucagon; Signal Transduction; Transfection | 1998 |
Pressure-induced expression of heat shock protein 70 mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression; Glucagon; HSP70 Heat-Shock Proteins; Hypertension; In Vitro Techniques; Isoquinolines; Male; Myocardium; Naphthalenes; Perfusion; Protein Biosynthesis; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Sulfonamides | 1998 |
Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Carbachol; Colforsin; Cyclic AMP; Fasting; Female; Food Deprivation; Gastrectomy; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Parietal Cells, Gastric; Rats; Stomach; Tissue Extracts; Vagotomy | 1999 |
Glicentin and oxyntomodulin modulate both the phosphoinositide and cyclic adenosine monophosphate signaling pathways in gastric myocytes.
Topics: Animals; Calcium; Carbachol; Colforsin; Cyclic AMP; Glicentin; Glucagon; Glucagon-Like Peptides; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Muscle Contraction; Muscle, Smooth; Oxyntomodulin; Peptide Fragments; Pertussis Toxin; Phosphatidylinositols; Protein Precursors; Pyloric Antrum; Rabbits; Signal Transduction; Type C Phospholipases; Virulence Factors, Bordetella | 1999 |
Decreases in cAMP phosphodiesterase activity in hepatocytes cultured with herbimycin A due to cellular microtubule polymerization related to inhibition of tyrosine phosphorylation of alpha-tubulin.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Benzoquinones; Cell-Free System; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Inhibitors; Glucagon; Lactams, Macrocyclic; Liver; Male; Microtubules; Phosphorylation; Polymers; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Wistar; Rifabutin; Tubulin | 1999 |
Effects of glucagon and glucagon-like peptide-1 on glucocorticoid secretion of dispersed rat adrenocortical cells.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Animals; Bucladesine; Colforsin; Corticosterone; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucocorticoids; In Vitro Techniques; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley; Steroids | 1999 |
Glucagon decreases cytokine induction of nitric oxide synthase and action on insulin secretion in RIN5F cells and rat and human islets of Langerhans.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Cytokines; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Glucagon; Humans; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Kinetics; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Cells, Cultured | 1999 |
Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells).
Topics: Animals; Calcium; Colforsin; Cyclic AMP; Cytoplasm; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Antagonists; Insulin Secretion; Islets of Langerhans; Leptin; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Kinase C; Protein Precursors; Rats; Tumor Cells, Cultured | 1999 |
Altered expression of Gi-protein and adenylyl cyclase activity in hearts from one kidney one clip hypertensive rats: effect of captopril.
Topics: Adenylyl Cyclases; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Colforsin; Glucagon; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension, Renovascular; Isoproterenol; Myocardium; Rats; Rats, Sprague-Dawley | 1999 |
The cyclic AMP-protein kinase A pathway restrains islet phospholipase A(2) activation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Carbachol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Melitten; Peptide Fragments; Phospholipases A; Protein Precursors; Rats; Rats, Sprague-Dawley; Signal Transduction; Sincalide; Vasoactive Intestinal Peptide | 2000 |
Membrane physical properties do not explain increased cyclic AMP production in hepatocytes from rats fed menhaden oil.
Topics: Animals; Cell Membrane; Colforsin; Cyclic AMP; Fish Oils; Glucagon; Hepatocytes; Insulin; Male; Membrane Lipids; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Signal Transduction; Spectroscopy, Fourier Transform Infrared | 2000 |
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulation; Glucagon; Glucose; Insulinoma; Islets of Langerhans; Kinetics; Membrane Proteins; Pancreatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Glucagon inhibits ACTH-stimulated cortisol secretion from dispersed human adrenocortical cells by activating unidentified receptors negatively coupled with the adenylate cyclase cascade.
Topics: Adenylyl Cyclases; Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Angiotensin II; Colforsin; Cyclic AMP; Glucagon; Humans; Hydrocortisone; Liver; Moloney murine leukemia virus; Receptors, Glucagon; Reverse Transcriptase Polymerase Chain Reaction; RNA-Directed DNA Polymerase; RNA, Messenger; Zona Fasciculata; Zona Glomerulosa | 2000 |
Volume overload cardiac hypertrophy exhibits decreased expression of g(s)alpha and not of g(i)alpha in heart.
Topics: Adenylyl Cyclases; Animals; Aorta, Thoracic; Arteriovenous Shunt, Surgical; Blood Pressure; Blotting, Northern; Body Weight; Cardiomegaly; Colforsin; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; Guanosine 5'-O-(3-Thiotriphosphate); Isoproterenol; Male; Myocardium; Organ Size; Protein Isoforms; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium Fluoride | 2000 |
Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding Sites; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Diabetes Mellitus; DNA; DNA-Binding Proteins; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Insulin; Islets of Langerhans; Male; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Vasoactive intestinal peptide regulates osteoclast activity via specific binding sites on both osteoclasts and osteoblasts.
Topics: Animals; Binding Sites; Bone Resorption; Calcitonin; Calcium; Cell Movement; Cells, Cultured; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Microscopy, Atomic Force; Osteoblasts; Osteoclasts; Parathyroid Hormone; Rats; Rats, Sprague-Dawley; Receptors, Vasoactive Intestinal Peptide; Stromal Cells; Vasoactive Intestinal Peptide | 2000 |
Lack of effect of incretin hormones on insulin release from pancreatic islets in the bile duct-ligated rats.
Topics: Animals; Bile Ducts; Bilirubin; Bucladesine; Cholestasis, Extrahepatic; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glucose Tolerance Test; Heterotrimeric GTP-Binding Proteins; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Ligation; Male; Peptide Fragments; Rats; Rats, Wistar | 2001 |
Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aspartic Acid Endopeptidases; Cell Line; Colforsin; Gene Expression Regulation; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Kinetics; Luciferases; Mice; Peptide Fragments; Proglucagon; Proprotein Convertase 1; Proprotein Convertases; Protein Precursors; Rats; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection | 2001 |
Hormone-specific combinations of isoforms of adenylyl cyclase and phosphodiesterase in the rat liver.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Calcium; Cobalt; Colforsin; Cyclic AMP; Glucagon; Glucose; In Vitro Techniques; Isoenzymes; Liver; Male; Perfusion; Rats; Rats, Wistar; Secretin; Vasoactive Intestinal Peptide | 2001 |
Regulation of hepatic cytochrome P450 2C11 via cAMP: implications for down-regulation in diabetes, fasting, and inflammation.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Cells, Cultured; Colforsin; Cyclic AMP; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 2; Diabetes Mellitus; Down-Regulation; Epinephrine; Fasting; Gene Expression Regulation, Enzymologic; Glucagon; Inflammation; Insulin; Liver; Male; Rats; Rats, Sprague-Dawley; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases | 2001 |
Defective stimulus-secretion coupling in islets of Psammomys obesus, an animal model for type 2 diabetes.
Topics: Animals; Colforsin; Diabetes Mellitus, Type 2; Diazoxide; Disease Models, Animal; Disease Susceptibility; Gerbillinae; Glucagon; Glucagon-Like Peptide 1; Glucose; Hyperglycemia; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Isoenzymes; Oxidation-Reduction; Peptide Fragments; Protein Kinase C; Protein Precursors; Rats; Rats, Sprague-Dawley; Reference Values; Signal Transduction; Tetradecanoylphorbol Acetate | 2001 |
Evaluation of islet heme oxygenase-CO and nitric oxide synthase-NO pathways during acute endotoxemia.
Topics: Animals; Blood Glucose; Carbon Monoxide; Colforsin; Cyclic AMP; Cyclic GMP; Endotoxemia; Female; Glucagon; Glucose; Heme Oxygenase (Decyclizing); In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Lipopolysaccharides; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Salmonella typhimurium; Time Factors | 2001 |
Antiproliferative actions of growth hormone-releasing hormone antagonists on MiaPaCa-2 human pancreatic cancer cells involve cAMP independent pathways.
Topics: Adenylyl Cyclases; Animals; Cell Division; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Growth Hormone-Releasing Hormone; Humans; Male; Mice; Mice, Nude; Muscles; Neoplasm Transplantation; Neuropeptides; Pancreatic Neoplasms; Pituitary Adenylate Cyclase-Activating Polypeptide; Radioimmunoassay; Secretin; Signal Transduction; Tumor Cells, Cultured; Vasoactive Intestinal Peptide | 2001 |
cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity in cultured rat hepatocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glucagon; Hepatocytes; Interleukin-1; Male; Muscle, Smooth, Vascular; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; Pulmonary Artery; Rats; Rats, Sprague-Dawley; RNA, Messenger; Second Messenger Systems; Sepsis; Transfection | 2001 |
Attenuation of age-related declines in glucagon-mediated signal transduction in rat liver by exercise training.
Topics: Adenylyl Cyclases; Aging; Animals; Autoradiography; Cell Membrane; Colforsin; Cyclic AMP; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gs; GTP-Binding Proteins; Guanylyl Imidodiphosphate; Immunoblotting; Iodine Radioisotopes; Liver; Male; Physical Endurance; Physical Exertion; Rats; Rats, Inbred F344; Receptors, Glucagon; Signal Transduction | 2001 |
Modulation of glucagon receptor expression and response in transfected human embryonic kidney cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cell Line; Colforsin; Cyclic AMP; Dactinomycin; Enzyme Inhibitors; Gene Expression; Glucagon; GTP-Binding Proteins; Humans; Isoproterenol; Kidney; Protein Synthesis Inhibitors; Rats; Receptors, Glucagon; RNA, Messenger; Sympathomimetics; Transfection | 2001 |
Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Colforsin; Cyclic AMP; Diazoxide; Glucagon; Glucagon-Like Peptide 1; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Phosphodiesterase Inhibitors; Potassium Channels; Protein Precursors; Rats; Rats, Wistar; Signal Transduction; Sodium Azide; Vasodilator Agents | 2002 |
NFAT regulates insulin gene promoter activity in response to synergistic pathways induced by glucose and glucagon-like peptide-1.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Calcium; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA-Binding Proteins; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Islets of Langerhans; Isoquinolines; NFATC Transcription Factors; Nuclear Proteins; Peptide Fragments; Promoter Regions, Genetic; Protein Precursors; Rats; Sulfonamides; Tacrolimus; Transcription Factors; Transcription, Genetic | 2002 |
Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets.
Topics: Animals; Benzoates; Cell Membrane; Colforsin; Cyclic AMP; Cytoplasmic Granules; DNA Primers; Excitatory Amino Acid Antagonists; Female; Gene Expression; Glucagon; Glutamic Acid; Glycine; Islets of Langerhans; Microscopy, Immunoelectron; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutamate; Reverse Transcriptase Polymerase Chain Reaction; Synaptophysin; Tissue Distribution | 2002 |
Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Lipolysis; Male; Peptide Fragments; Phosphofructokinase-2; Protein Precursors; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2003 |
Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Calcium; Cerulenin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Membrane Potentials; Peptide Fragments; Potassium; Protein Precursors; Rats; Rats, Wistar | 2002 |
Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis.
Topics: Animals; Apoptosis; beta Catenin; Blood Glucose; Cell Line; Cell Survival; Colforsin; Cricetinae; Cycloheximide; Cytokines; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; Exenatide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose Tolerance Test; In Situ Nick-End Labeling; Insulin; Islets of Langerhans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Peptides; Protein Precursors; Protein Synthesis Inhibitors; Rats; Rats, Wistar; Receptors, Glucagon; Signal Transduction; Streptozocin; Trans-Activators; Venoms | 2003 |
Glucagon-like peptide-1 mobilizes intracellular Ca2+ and stimulates mitochondrial ATP synthesis in pancreatic MIN6 beta-cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Signaling; Carbachol; Cell Line; Chelating Agents; Cholinergic Agonists; Colforsin; Cyclic AMP; Diazoxide; Egtazic Acid; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Homeostasis; Insulin; Insulin Secretion; Islets of Langerhans; Macrocyclic Compounds; Mitochondria; Oxazoles; Peptide Fragments; Protein Precursors; Ryanodine; Ryanodine Receptor Calcium Release Channel; Thionucleotides | 2003 |
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin | 2003 |
Mechanisms involved in glucagon-like peptide-1 (7-36) amide action on the rat hypothalamo-neurohypophysial system.
Topics: Analysis of Variance; Angiotensin II; Animals; Calcium; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Hypothalamo-Hypophyseal System; Male; Neurotransmitter Agents; Organ Culture Techniques; Oxytocin; Peptide Fragments; Rats; Rats, Wistar; Second Messenger Systems; Vasopressins; Water-Electrolyte Balance | 2003 |
PACAP is expressed in secretory granules of insulin and glucagon cells in human and rodent pancreas. Evidence for generation of cAMP compartments uncoupled from hormone release in diabetic islets.
Topics: Animals; Colforsin; Cyclic AMP; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Glucagon; Glucose; Humans; Immunohistochemistry; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Microscopy, Immunoelectron; Neuropeptides; Pancreas; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Wistar | 2003 |
cAMP promotes pancreatic beta-cell survival via CREB-mediated induction of IRS2.
Topics: Animals; Apoptosis; Cell Line; Cell Survival; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Diabetes Mellitus; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Glucose Intolerance; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Intracellular Signaling Peptides and Proteins; Islets of Langerhans; Mice; Mice, Transgenic; Peptide Fragments; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Precursors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Transfection; Transgenes; Tumor Cells, Cultured | 2003 |
The rat pancreatic islets: a reliable tool to study islet responses to cholecystokinin receptor occupation.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Animals; Blotting, Western; Colforsin; Fetus; Glucagon; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Microscopy, Confocal; Rats; Receptors, Cholecystokinin; Receptors, Somatostatin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin | 2004 |
Palmitate stimulation of glucagon secretion in mouse pancreatic alpha-cells results from activation of L-type calcium channels and elevation of cytoplasmic calcium.
Topics: Animals; Colforsin; Diazoxide; Glucagon; Islets of Langerhans; Isradipine; Kinetics; Membrane Potentials; Mice; Mice, Inbred Strains; Palmitic Acid; Potassium; Triazenes | 2004 |
cAMP-dependent tyrosine phosphorylation of subunit I inhibits cytochrome c oxidase activity.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; Cattle; Colforsin; Crystallography, X-Ray; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electron Transport Complex IV; Glucagon; Kinetics; Liver; Lung; Models, Molecular; Myocardium; Phosphorylation; Phosphotyrosine; Protein Conformation; Protein Subunits; Theophylline | 2005 |
Modulation of glycogen phosphorylase activity affects 5-phosphoribosyl-1-pyrophosphate availability in rat hepatocyte cultures.
Topics: Amides; Animals; Arginine Vasopressin; Bucladesine; Caffeine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glycogen Phosphorylase; Hepatocytes; Indoles; Liver; Male; Phenylephrine; Phosphoribosyl Pyrophosphate; Rats; Rats, Wistar; Time Factors | 2004 |
Free fatty acids increase PGC-1alpha expression in isolated rat islets.
Topics: Animals; Cells, Cultured; Colforsin; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Liver; Male; Mice; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; RNA, Messenger; RNA, Small Interfering; Transcription Factors | 2005 |
Effects of the C-terminal peptide of the alphaS subunit of the G protein on the regulation of adenylyl cyclase and protein kinase A activities by biogenic amines and glucagon in mollusk and rat muscles.
Topics: Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Biogenic Monoamines; Cell Membrane; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Drug Interactions; Glucagon; GTP-Binding Protein alpha Subunits; Guanylyl Imidodiphosphate; Isoproterenol; Mollusca; Muscles; Peptides; Rats; Sodium Fluoride | 2005 |
PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP.
Topics: Animals; CDX2 Transcription Factor; Colforsin; Colonic Neoplasms; Cricetinae; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enteroendocrine Cells; Genes, Dominant; Glucagon; Guanine Nucleotide Exchange Factors; Homeodomain Proteins; Humans; Intestinal Mucosa; Intestinal Polyps; Intestines; Islets of Langerhans; Mice; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Proglucagon; Protein Precursors; Signal Transduction; Transcription Factors | 2005 |
p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.
Topics: Acetylcysteine; Adenoviridae; Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Type 1; Disease Models, Animal; Enzyme Inhibitors; Gene Silencing; Glucagon; Gluconeogenesis; Glucose; Glucose-6-Phosphatase; Hepatocytes; Imidazoles; Liver; Mice; p38 Mitogen-Activated Protein Kinases; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phosphoenolpyruvate Carboxykinase (GTP); Phosphorylation; Promoter Regions, Genetic; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Streptozocin; Trans-Activators; Transcription Factors; Transfection | 2005 |
Enhanced expression of Gialpha protein and adenylyl cyclase signaling in aortas from 1 kidney 1 clip hypertensive rats.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Angiotensin II; Animals; Antihypertensive Agents; Aorta; Atrial Natriuretic Factor; Captopril; Colforsin; Dose-Response Relationship, Drug; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension, Renovascular; Immunoblotting; Isoproterenol; Peptide Fragments; Rats; Rats, Sprague-Dawley; Renal Artery Obstruction; Signal Transduction; Sodium Fluoride; Time Factors | 2006 |
Glucose release as a response to glucagon in rat hepatocyte culture: involvement of NO signaling.
Topics: Animals; Bucladesine; Cell Separation; Cells, Cultured; Colforsin; Glucagon; Glucose; Glycogen; Guanidines; Hepatocytes; Male; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; S-Nitroso-N-Acetylpenicillamine; Signal Transduction | 2008 |
Function and expression of melatonin receptors on human pancreatic islets.
Topics: Animals; Cell Line, Tumor; Colforsin; Cyclic AMP; Glucagon; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Melatonin; RNA, Messenger; Second Messenger Systems | 2008 |
Inhibition of glucagon-signaling and downstream actions by interleukin 1beta and tumor necrosis factor alpha in cultured primary rat hepatocytes.
Topics: Animals; Cells, Cultured; Colforsin; Cyclic AMP; Gene Expression Regulation, Enzymologic; Glucagon; Glucokinase; Glucose; Glycogen; Hepatocytes; Humans; Insulin; Interleukin-1beta; Male; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; Recombinant Proteins; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2008 |
Glucagon receptor mediates calcium signaling by coupling to G alpha q/11 and G alpha i/o in HEK293 cells.
Topics: Calcium; Calcium Signaling; Cell Line; Colforsin; Cyclic AMP; Enzyme Inhibitors; Glucagon; GTP-Binding Protein alpha Subunits, Gi-Go; GTP-Binding Protein alpha Subunits, Gq-G11; Humans; Pertussis Toxin; Receptors, Glucagon; RNA Interference; Signal Transduction; Thapsigargin | 2009 |
GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
Topics: Animals; Calcium Channels, L-Type; Calcium Channels, N-Type; Carrier Proteins; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epinephrine; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Guanine Nucleotide Exchange Factors; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred C57BL | 2010 |
Glucagon stimulates hepatic FGF21 secretion through a PKA- and EPAC-dependent posttranscriptional mechanism.
Topics: AMP-Activated Protein Kinases; Animals; Bucladesine; Colforsin; Cyclic AMP-Dependent Protein Kinases; Fibroblast Growth Factors; Glucagon; Guanine Nucleotide Exchange Factors; Hep G2 Cells; Humans; Insulin; Liver; Male; Models, Biological; p38 Mitogen-Activated Protein Kinases; rap1 GTP-Binding Proteins; Rats, Sprague-Dawley; RNA, Messenger; Transcription, Genetic | 2014 |
Post-Translational Regulation of the Glucose-6-Phosphatase Complex by Cyclic Adenosine Monophosphate Is a Crucial Determinant of Endogenous Glucose Production and Is Controlled by the Glucose-6-Phosphate Transporter.
Topics: Adenoviruses, Human; Animals; Antiporters; Caco-2 Cells; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Epithelial Cells; Gene Expression Regulation; Genetic Vectors; Glucagon; Glucose; Glucose-6-Phosphatase; Glucose-6-Phosphate; Hep G2 Cells; Humans; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Phosphorylation; Protein Biosynthesis; Protein Subunits; Rats; Signal Transduction | 2016 |
CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells.
Topics: Animals; Cells, Cultured; Colforsin; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Female; Glucagon; Glucagon-Secreting Cells; Glucose; Humans; Male; Membrane Potentials; Mice; Middle Aged; Mutation; Somatostatin-Secreting Cells | 2017 |
Pancreatic α- and β-cellular clocks have distinct molecular properties and impact on islet hormone secretion and gene expression.
Topics: Animals; Cells, Cultured; Circadian Clocks; Colforsin; Enzyme Activators; Gene Expression Profiling; Gene Expression Regulation; Glucagon; Glucagon-Secreting Cells; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Models, Animal; Sequence Analysis, RNA; Time Factors | 2017 |
26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Epinephrine; Glucagon; Hepatocytes; Humans; Kidney; Male; Mice; Muscle, Skeletal; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Proteostasis Deficiencies; Rats; Rats, Sprague-Dawley; Rats, Wistar; Ubiquitinated Proteins | 2019 |
O-GlcNAcylated p53 in the liver modulates hepatic glucose production.
Topics: Acetylglucosamine; Animals; Base Sequence; Caloric Restriction; Cell Line; Colforsin; Diabetes Mellitus, Type 2; Epinephrine; Glucagon; Glucocorticoids; Gluconeogenesis; Glucose; Glycosylation; Hepatocytes; Humans; Hydrocortisone; Hyperglycemia; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Liver; Mice, Inbred C57BL; Mice, Knockout; Obesity; Phosphoenolpyruvate Carboxykinase (GTP); Promoter Regions, Genetic; Protein Binding; Protein Stability; Pyruvic Acid; RNA, Messenger; Transcription, Genetic; Tumor Suppressor Protein p53 | 2021 |