glucagon has been researched along with 1-methyl-3-isobutylxanthine in 136 studies
| Studies (glucagon) | Trials (glucagon) | Recent Studies (post-2010) (glucagon) | Studies (1-methyl-3-isobutylxanthine) | Trials (1-methyl-3-isobutylxanthine) | Recent Studies (post-2010) (1-methyl-3-isobutylxanthine) |
|---|---|---|---|---|---|
| 26,039 | 1,498 | 3,054 | 5,148 | 5 | 279 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 57 (41.91) | 18.7374 |
| 1990's | 58 (42.65) | 18.2507 |
| 2000's | 20 (14.71) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (0.74) | 2.80 |
| Authors | Studies |
|---|---|
| Cerasi, E; Rabinovitch, A; Sharp, GW | 1 |
| Hamprecht, B; Moroder, L; Propst, F; Wünsch, E | 1 |
| Fischer, PW; Marks, GS; Morgan, RO; Stephens, JK | 1 |
| Brubaker, PL; Lévesque, L; Sun, AM | 1 |
| Bataille, D; Demirpence, E; Gros, L; Jarrousse, C; Kervran, A | 1 |
| Benito, M; de Juan, C; Fabregat, I | 1 |
| Calvo, JR; Goberna, R; Lucas, M; Sánchez, V | 1 |
| Itoh, H; Komatsu, R; Kono, N; Matsumura, T; Matsuyama, T; Matsuzawa, Y; Namba, M; Oda, Y; Tanaka, M; Watanabe, N | 1 |
| Grigg, JA; Janssens, PA | 1 |
| Boege, F; Cantrill, RC; Hahn, M; Heithier, H; Kurstjens, NP | 1 |
| Marumo, F; Nonoguchi, H; Tomita, K | 1 |
| Irie, M; Kajinuma, H; Suzuki, K; Watanabe, K | 1 |
| Akamatu, N; Shima, S | 1 |
| de Rouffignac, C; Dublineau, I; Elalouf, JM; Pradelles, P | 1 |
| Ahrén, B; Efendic, S; Karlsson, S; Ostenson, CG; Sandberg, E | 1 |
| Helqvist, S; Johannesen, J; Nerup, J | 1 |
| Arnold, R; Bächle, R; Fehmann, HC; Göke, B; Göke, R; Wagner, B | 1 |
| Classen, M; Fürlinger, C; Janczewska, I; Schepp, W; Schmidtler, J; Schusdziarra, V; Weigert, N | 1 |
| Jansen, PL; Ottenhoff, R; Oude Elferink, RP; Roelofsen, H | 1 |
| Baker, KM; Beinlich, CJ; Morgan, HE; White, GJ | 1 |
| Berrow, NS; Lacey, RJ; Morgan, NG; Scarpello, JH | 1 |
| Bonner-Weir, S; Leahy, JL; Weir, GC | 2 |
| Pipeleers, DG; Schuit, FC | 1 |
| Morse, DE; Ness, JC | 1 |
| Hirata, Y; Machiyama, E; Ohgawara, H; Sakurai, Y; Tasaka, Y | 1 |
| Janssens, PA; Maher, F | 1 |
| Anand-Srivastava, MB | 1 |
| Kelly, KJ; Rayfield, EJ | 1 |
| Danoff, A; Fleischer, N; Pasmantier, R; Schubart, UK | 1 |
| Blackmore, PF; Exton, JH | 1 |
| Gross, R; Karmann, H; Laurent, F; Mialhe, P; Strosser, MT | 1 |
| Houslay, MD; Irvine, F; Pyne, NJ | 1 |
| Hsueh, AJ; Kasson, BG; Lim, P | 1 |
| Al-Turk, WA; Othman, S; Shaheen, O | 1 |
| Campbell, RM; Scanes, CG | 1 |
| Müller, MJ; Seitz, HJ | 1 |
| Goodner, CJ; Sweet, IR; Weigle, DS | 1 |
| Creutzfeldt, W; Siegel, EG | 1 |
| Hara, M; Ogawa, A; Sasaki, H; Sato, N; Suda, K; Takahashi, K; Wada, K; Wakasugi, K; Yamatani, K | 1 |
| Patel, TB; Rashed, HM | 1 |
| Houslay, MD; Murphy, GJ | 1 |
| Baquerizo, H; Pukel, C; Rabinovitch, A | 1 |
| Kojima, I; Mine, T; Ogata, E | 1 |
| Brubaker, PL | 1 |
| Houslay, MD; Irvine, FJ | 1 |
| Ariav, Y; Cerasi, E; Corcos, AP; Kaiser, N; Tur-Sinai, A | 1 |
| Bertrand, J; Demidem, A; Durand, A; Haftek, M; Thivolet, CH | 1 |
| Demigne, C; Morand, C; Remesy, C; Yacoub, C | 1 |
| Cerasi, E; Eylon, L; Nesher, R; Segal, N | 1 |
| Boyd, AE; Hill, RS; Rajan, AS | 1 |
| Chua, BH; Haneda, T; Morgan, HE; Watson, PA; Xenophontos, XP | 1 |
| Christoffersen, T; Johansen, EJ; Refsnes, M | 1 |
| Abramovitch, E; Cerasi, E; Nesher, R | 1 |
| Christoffersen, T; Gjone, IH; Gladhaug, IP; Ostby, E; Refsnes, M; Thoresen, GH | 1 |
| Bratusch-Marrain, P; Breitenecker, F; Gampe, J; Komjati, M; Troch, I; Vierhapper, H; Waldhäusl, W | 1 |
| Hermansen, K | 1 |
| Gagnon, G; Regoli, D; Rioux, F | 1 |
| Hasegawa, K; Koga, M; Namai, K | 1 |
| Hazeki, O; Ui, M | 1 |
| Grill, V | 1 |
| Halban, PA; Renold, AE; Trimble, ER; Wollheim, CB | 1 |
| Bataille, D; Dutrillaux, MC; Gespach, C; Rosselin, G | 1 |
| Heimberg, M; Keyes, WG; Morgan, DW; Shaheen, O; Wilcox, HG | 1 |
| Gaben, AM; Jahchan, T; Rosselin, G; Swierczewski, W | 1 |
| Efendić, S; Grill, V; Nylén, A; Ostenson, CG | 1 |
| Ichihara, A; Nakamura, T; Noda, C; Shinjyo, F | 1 |
| Hedeskov, CJ; Knudsen, P; Kofod, H; Lernmark, A | 1 |
| Barras, E; Fletcher, DJ; Grogan, WM; Weir, GC | 1 |
| Kaplan, SA; Whitson, RH | 1 |
| Draznin, B; Leitner, JW; Steinberg, JP; Sussman, KE | 1 |
| Halban, PA; Meda, P; Orci, L; Renold, AE; Weir, GC; Wollheim, CB | 1 |
| Horie, H; Kanatsuka, A; Kasanuki, J; Makino, H; Osegawa, M; Suzuki, T; Yoshida, S | 1 |
| Devis, PE; Grohol, SH; Taub, M | 1 |
| Kobayashi, R; Kumegawa, M; Maeda, N; Mizunuma, H; Shima, H; Tanaka, S; Tashima, Y | 1 |
| Ogihara, M | 1 |
| Kachra, Z; Posner, BI; Yang, CR | 1 |
| Hannaert, JC; Ling, Z; Pipeleers, D | 1 |
| Dégano, P; Fontela, T; García-Hermida, O; Marco, J; Salas, M; Silvestre, RA | 1 |
| Ling, Z; Pipeleers, DG | 1 |
| Kachra, Z; Murphy, LJ; Posner, BI; Yang, CR | 1 |
| Armstrong, MB; Poitout, V; Robertson, RP; Sorenson, RL; Stout, LE; Walseth, TF | 1 |
| Abrahamsen, N; Nishimura, E | 1 |
| Asa, SL; Brubaker, PL; Drucker, DJ; Jin, T; Young, TA | 1 |
| Abrahamsen, N; Lundgren, K; Nishimura, E | 1 |
| Absood, A; Maruno, K; Said, SI | 1 |
| Hinds, TR; Storm, DR; Wayman, GA | 1 |
| Drucker, DJ; Gajic, D | 1 |
| Bertuzzi, F; Davalli, AM; DiCarlo, V; Freschi, M; Gavazzi, F; Pontiroli, AE; Pozza, G; Scaglia, L; Socci, C | 1 |
| Eikvar, L; Eskild, W; Hansson, V; Taskén, KA | 1 |
| Chiba, S; Horiuchi, A; Iwatsuki, K; Kuroda, T; Ren, LM | 1 |
| Bogoyevitch, MA; Fuller, SJ; Sugden, PH | 1 |
| Brubaker, PL; Stobie-Hayes, KM | 1 |
| Kajiyama, Y; Sanai, Y; Ui, M | 1 |
| Hanafusa, T; Kuwajima, M; Matsumura, T; Matsuzawa, Y; Miki, H; Mineo, I; Miyagawa, J; Nakajima, H; Namba, M; Nishimura, T | 1 |
| Laychock, SG | 1 |
| Bouwens, L; De Vos, A; Heimberg, H; Madsen, O; Moens, K; Pipeleers, D; Quartier, E; Schuit, F; Van Schaftingen, E | 1 |
| Azizeh, BY; Houslay, MD; Hruby, VJ; Johnson, DG; Phelps, JR; Trivedi, D; Van Tine, BA | 1 |
| Ahrén, B; Karlsson, S; Simonsson, E | 2 |
| Dachicourt, N; Gangnerau, MN; Giroix, MH; Portha, B; Serradas, P | 1 |
| Boissard, C; Chastre, E; Marie, JC; Phan, HH; Rosselin, G | 1 |
| Brown, KS; Durham, SK; Kalinowski, SS; Megill, JR; Mookhtiar, KA | 1 |
| Deeg, MA; Verchere, CB | 1 |
| Ding, WG; Gromada, J | 1 |
| Haneda, T; Kikuchi, K; Osaki, J; Sakai, H | 1 |
| Christ, B; Jungermann, K; Nath, A | 1 |
| Chaudry, IH; Mahmoud, MS; Wang, P | 1 |
| Nakata, M; Tanaka, H; Yada, T; Yaekura, K | 1 |
| Egan, JM; Montrose, MH; Montrose-Rafizadeh, C; Moyes, CD; Roth, J; Wang, Y; Yang, H | 1 |
| Fukuzawa, J; Haneda, T; Kashiwagi, Y; Kikuchi, K; Oi, S; Osaki, J; Sakai, H | 1 |
| Lu, D; Saito, I; Shibata, H; Takeuchi, T; Tamemoto, H | 1 |
| Chen, D; Håkanson, R; Lundquist, I; Nordin, G; Salehi, A | 1 |
| Mamujee, SN; Sun, AM; Vacek, I; Wheeler, MB; Zhou, D | 1 |
| Bertuzzi, F; Di Carlo, V; Leone, BE; Nano, R; Piemonti, L; Pozza, G; Socci, C | 1 |
| Akesson, B; Lundquist, I | 1 |
| Aust, G; Nguyen, TB; Scherbaum, WA; Seissler, J; Steinbrenner, H | 1 |
| Daniel, PB; Habener, JF; Hussain, MA | 1 |
| Fujioka, T; Ishibashi, K; Ui, M | 1 |
| Brubaker, PL; Dhanvantari, S; Izzo, A; Jansen, E | 1 |
| Díaz-Miguel, M; González, N; Márquez, L; Valverde, I; Villanueva-Peñacarrillo, ML | 1 |
| Bergamini, E; Bombara, M; Fierabracci, V; Masiello, P; Novelli, M; Prentki, M; Vittorini, S | 1 |
| Aizawa, T; Hashizume, K; Komatsu, M; Sato, Y; Yamada, S; Yamauchi, K | 1 |
| De Proft, R; Dejonghe, S; Gorus, F; Ling, Z; Pipeleers, D; Schuit, F; Winnock, F | 1 |
| Ekelund, M; Henningsson, R; Lundquist, I; Salehi, A | 1 |
| Civelek, VN; Corkey, BE; Cunningham, BA; Daley, JT; Deeney, JT; Dillon, JS; Richard, AM; Tornheim, K; Yaney, GC | 1 |
| Aizawa, T; Hashizume, K; Kojima, I; Komatsu, M; Sato, Y; Yamada, S; Yamauchi, K | 1 |
| Lee, JW; Romsos, DR; Swick, AG | 1 |
| Akesson, B; Lundquist, I; Panagiotidis, G; Westermark, P | 1 |
| Buettger, CW; Carr, RD; Collins, HW; Doliba, NM; Li, C; Magnuson, MA; Matschinsky, FM; Najafi, H; Qin, W; Vatamaniuk, MZ; Zelent, D | 1 |
| Dornonville de la Cour, C; Håkanson, R; Lundquist, I; Salehi, A | 1 |
| Hope, KM; Leroy, E; Oseid, E; Robertson, RP; Tran, PO; Zhou, H | 1 |
| Julien, S; Lainé, J; Morisset, J | 1 |
| Behie, LA; Bodnar, CA; Kallos, MS; Petropavlovskaia, M; Rosenberg, L; Sen, A | 1 |
| Cabezas-Herrera, J; Gonzalez-Muñoz, C; Hernández-Cascales, J; Nieto-Cerón, S | 1 |
| Aranda-Domene, R; Arribas-Leal, JM; Canovas-Lopez, S; Hernández-Cascales, J; Orenes-Piñero, E | 1 |
2 review(s) available for glucagon and 1-methyl-3-isobutylxanthine
| Article | Year |
|---|---|
Hormonal effects on the regulation of hepatic heme biosynthesis.
Topics: 1-Methyl-3-isobutylxanthine; 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Androstanes; Animals; Bucladesine; Chick Embryo; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucose; Heme; Hormones; Humans; Hydrocortisone; Insulin; Ketosteroids; Liver; Porphyrias; Porphyrins; Pregnanes; Structure-Activity Relationship; Thyroid Hormones | 1979 |
Experimental reduction of B-cell mass: implications for the pathogenesis of diabetes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Arginine; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Drug Synergism; Glucagon; Glucose; Glucose Tolerance Test; Histocytochemistry; Humans; Immunologic Techniques; In Vitro Techniques; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Pancreatectomy; Rats; Rats, Inbred Strains | 1986 |
134 other study(ies) available for glucagon and 1-methyl-3-isobutylxanthine
| Article | Year |
|---|---|
Adenosine 3',5'-monophosphate-dependent and -independent inhibitory effects of epinephrine on insulin release in rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Cholera Toxin; Cyclic AMP; Epinephrine; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Phentolamine | 1978 |
The influence of secretin, glucagon and other peptides, of amino acids, prostaglandin endoperoxide analogues and diazepam on the level of adenosine 3',5'-cyclic monophosphate in neuroblastoma x glioma hybrid cells.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Amino Acids; Cyclic AMP; Diazepam; Glioma; Glucagon; Humans; Hybrid Cells; Neuroblastoma; Neurotransmitter Agents; Peptides; Prostaglandin Endoperoxides, Synthetic; Secretin | 1979 |
Maintenance of long-term secretory function by microencapsulated islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; Alginates; Animals; Biocompatible Materials; Enzyme Activation; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membranes, Artificial; Polylysine; Protein Kinase C; Protein Kinases; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Time Factors | 1992 |
Characterization of binding sites for oxyntomodulin on a somatostatin-secreting cell line (RIN T3).
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Binding Sites; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Glucagon; Glucagon-Like Peptides; Insulinoma; Iodine Radioisotopes; Oxyntomodulin; Rats; Somatostatin; Tumor Cells, Cultured | 1992 |
Regulation of albumin expression in fetal rat hepatocytes cultured under proliferative conditions: role of epidermal growth factor and hormones.
Topics: 1-Methyl-3-isobutylxanthine; Albumins; Animals; Cell Division; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Epidermal Growth Factor; Fetus; Gene Expression Regulation; Glucagon; Liver; Norepinephrine; Phorbol Esters; Rats; Rats, Inbred Strains; RNA, Messenger; Signal Transduction; Time Factors; Vasopressins | 1992 |
Glycogenolytic effect of pancreastatin in isolated rat hepatocytes is mediated by a cyclic-AMP-independent Ca(2+)-dependent mechanism.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Calcium; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Egtazic Acid; Glucagon; Glucose; Kinetics; Liver; Liver Glycogen; Male; Rats; Rats, Inbred Strains | 1992 |
Glucagonlike peptide-1(7-36)amide suppresses glucagon secretion and decreases cyclic AMP concentration in cultured In-R1-G9 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Clone Cells; Cricetinae; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulinoma; Kinetics; Pancreatic Neoplasms; Peptide Fragments; Peptides | 1992 |
Hormones regulating hepatic glycogenolysis in two chelonians use cyclic AMP, and not Ca2+, as intracellular messenger.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcimycin; Calcium; Culture Media; Cyclic AMP; Epinephrine; Glucagon; Hormones; Iodocyanopindolol; Ligands; Liver; Liver Glycogen; Organ Culture Techniques; Phosphorylases; Pindolol; Sympatholytics; Turtles | 1992 |
Multiple hormone actions: the rises in cAMP and Ca++ in MDCK-cells treated with glucagon and prostaglandin E1 are independent processes.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Calcium; Carbachol; Cell Line; Colforsin; Cyclic AMP; Dogs; Fluorescent Dyes; Glucagon; Indoles; Isoproterenol; Kidney; Kinetics; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1990 |
Effects of endothelin on peptide-dependent cyclic adenosine monophosphate accumulation along the nephron segments of the rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Calcitonin; Calcium; Cyclic AMP; Endothelins; Glucagon; In Vitro Techniques; Indomethacin; Isoproterenol; Isoquinolines; Kidney Tubules; Loop of Henle; Nicardipine; Parathyroid Hormone; Peptides; Piperazines; Protein Kinase C; Rats | 1990 |
Adrenalectomy-induced alterations in glucagon binding and lipolysis in isolated rat adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Deaminase; Adipose Tissue; Adrenalectomy; Animals; Bucladesine; Cyclic AMP; Dihydroalprenolol; Glucagon; Isoproterenol; Lipolysis; Male; Rats; Rats, Inbred Strains; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1990 |
Multiple controls by adenosine receptors on the adenylate cyclase in the rat hepatic membrane.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cell Membrane; Cyclic AMP; Glucagon; Guanosine Triphosphate; In Vitro Techniques; Liver; Male; Phenylisopropyladenosine; Rats; Receptors, Purinergic; Sodium Chloride | 1990 |
In vitro desensitization of isolated nephron segments to vasopressin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine Vasopressin; Cyclic AMP; Deamino Arginine Vasopressin; Glucagon; In Vitro Techniques; Indomethacin; Kidney Medulla; Male; Nephrons; Rats; Rats, Inbred Strains; Reference Values | 1990 |
Effects of porcine diazepam-binding inhibitor on insulin and glucagon secretion in vitro from the rat endocrine pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Diazepam Binding Inhibitor; Glucagon; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Neuropeptides; Rats; Rats, Inbred Strains; Somatostatin; Stimulation, Chemical; Swine | 1990 |
Not all insulin secretagogues sensitize pancreatic islets to recombinant human interleukin 1 beta.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Culture Media; DNA; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Rats; Rats, Inbred Strains; Recombinant Proteins; Tolbutamide | 1990 |
Priming effect of glucagon-like peptide-1 (7-36) amide, glucose-dependent insulinotropic polypeptide and cholecystokinin-8 at the isolated perfused rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Colforsin; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Peptide Fragments; Peptides; Perfusion; Rats; Rats, Inbred Strains; Sincalide | 1991 |
GLP-1-(7-36) amide, -(1-37), and -(1-36) amide: potent cAMP-dependent stimuli of rat parietal cell function.
Topics: 1-Methyl-3-isobutylxanthine; Aminopyrine; Animals; Biological Transport; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Female; Gastric Acid; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Histamine; In Vitro Techniques; Inositol Phosphates; Kinetics; Parietal Cells, Gastric; Peptide Fragments; Peptides; Pertussis Toxin; Rats; Rats, Inbred Strains; Virulence Factors, Bordetella | 1991 |
Hepatocanalicular organic-anion transport is regulated by protein kinase C.
Topics: 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Anion Transport Proteins; Anions; Bile Canaliculi; Biological Transport; Bucladesine; Carrier Proteins; Colforsin; Cyclic AMP; Glucagon; Glutathione; Male; Protein Kinase C; Rats; Rats, Inbred Strains; Second Messenger Systems; Staurosporine; Tetradecanoylphorbol Acetate; Vasopressins | 1991 |
Control of growth in the neonatal pig heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Animals, Newborn; Cyclic AMP; Enalapril; Glucagon; Heart; Heart Rate; In Vitro Techniques; Muscle Proteins; Myocardium; Norepinephrine; Propranolol; Protein Kinases; Ribosomes; Swine | 1991 |
Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic beta-Antagonists; Animals; Atenolol; Clenbuterol; Colforsin; Cyclic AMP; Glucagon; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Propanolamines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1991 |
Abnormal insulin secretion in a streptozocin model of diabetes. Effects of insulin treatment.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains | 1985 |
Regulation of adenosine 3',5'-monophosphate levels in the pancreatic B cell.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glucose; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Pancreatic Polypeptide; Rats; Rats, Inbred Strains; Somatostatin | 1985 |
Regulation of galactokinase gene expression in Tetrahymena thermophila. I. Intracellular catecholamine control of galactokinase expression.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic Agonists; Animals; Caffeine; Catecholamines; Cyclic AMP; Galactokinase; Genes; Glucagon; Glucose; Histamine; Insulin; Kinetics; Tetrahymena; Theophylline | 1985 |
A study of insulin and glucagon secretion from adult rat pancreatic monolayer islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Culture Media; Culture Techniques; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Microbial Collagenase; Rats; Rats, Inbred Strains | 1985 |
Glucagon and insulin regulate in vitro hepatic glycogenolysis in the axolotl Ambystoma mexicanum via changes in tissue cyclic AMP concentration.
Topics: 1-Methyl-3-isobutylxanthine; Ambystoma; Animals; Cyclic AMP; Enzyme Activation; Epinephrine; Glucagon; Glucose; In Vitro Techniques; Insulin; Liver Glycogen; Phosphorylase a | 1986 |
Regulation of adenylate cyclase by adenosine and other agonists in rat myocardial sarcolemma.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Catecholamines; Cations, Divalent; Enzyme Activation; Glucagon; Guanine Nucleotides; Myocardium; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Purinergic; Sarcolemma | 1985 |
Virus-induced alterations in cyclic adenosine monophosphate generation in hamster islets of Langerhans.
Topics: 1-Methyl-3-isobutylxanthine; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Cricetinae; Cyclic AMP; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Secretory Rate | 1986 |
P19, a hormonally regulated phosphoprotein of peptide hormone-producing cells: secretagogue-induced phosphorylation in AtT-20 mouse pituitary tumor cells and in rat and hamster insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenoma, Islet Cell; Adrenocorticotropic Hormone; Animals; Colforsin; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Glucagon; Insulinoma; Isoproterenol; Pancreatic Neoplasms; Phosphoproteins; Phosphorylation; Pituitary Neoplasms; Potassium; Rats; Tetradecanoylphorbol Acetate | 1986 |
Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Adrenergic alpha-Agonists; Aluminum; Aluminum Compounds; Angiotensin II; Calcium; Colforsin; Cyclic AMP; Drug Synergism; Fluorides; Glucagon; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Liver; Pertussis Toxin; Phorbols; Protein Kinase C; Sodium Fluoride; Tetradecanoylphorbol Acetate; Thionucleotides; Vasopressins; Virulence Factors, Bordetella | 1986 |
Glucagon and somatostatin secretion from the perfused splenic bulb of duck pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Amino Acids; Animals; Arginine; Ducks; Glucagon; Glucose; Insulin; Insulin Secretion; Male; Pancreas; Perfusion; Somatostatin | 1986 |
The phorbol ester TPA inhibits cyclic AMP phosphodiesterase activity in intact hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic AMP; Drug Synergism; Glucagon; Liver; Male; Rats; Tetradecanoylphorbol Acetate | 1986 |
Vasoactive intestinal peptide stimulates androgen biosynthesis by cultured neonatal testicular cells.
Topics: 1-Methyl-3-isobutylxanthine; 3-Hydroxysteroid Dehydrogenases; Animals; Animals, Newborn; Cell Separation; Cells, Cultured; Cyclic AMP; Glucagon; Luteinizing Hormone; Male; Peptide PHI; Pregnenolone; Progesterone; Rats; Rats, Inbred Strains; Secretin; Testis; Testosterone; Vasoactive Intestinal Peptide | 1986 |
Effect of forskolin on cAMP accumulation and ketogenesis in isolated hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Glucagon; Hypothyroidism; In Vitro Techniques; Ketone Bodies; Liver; Male; Rats | 1986 |
Growth hormone inhibition of glucagon- and cAMP-induced lipolysis by chicken adipose tissue in vitro.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adipose Tissue; Animals; Chickens; Cyclic AMP; Glucagon; Growth Hormone; Lipolysis; Male | 1987 |
Interrelation between thyroid state and the effect of glucagon on gluconeogenesis in perfused rat livers.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Alanine; Aminoisobutyric Acids; Animals; Bucladesine; Glucagon; Gluconeogenesis; Hyperthyroidism; Hypothyroidism; Lactates; Lactic Acid; Liver; Male; Rats; Rats, Inbred Strains; Urea | 1987 |
A kinetic analysis of hepatocyte responses to a glucagon pulse: mechanism and metabolic consequences of differences in response decay times.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Glucagon; Gluconeogenesis; Glucose; Glycogen; Kinetics; Liver; Male; Perfusion; Rats; Rats, Inbred Strains; Receptors, Gastrointestinal Hormone; Receptors, Glucagon | 1987 |
Effect of low concentrations of glucagon on insulin release and cyclic AMP content in isolated rat islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Culture Techniques; Cyclic AMP; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains | 1987 |
Two types of hormone-responsive adenylate cyclase in the rat liver.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Glucagon; Glucose; In Vitro Techniques; Insulin; Kinetics; Liver; Liver Glycogen; Male; Oxymetazoline; Perfusion; Rats; Rats, Inbred Strains; Secretin | 1987 |
Glucagon-stimulated calcium efflux in the isolated perfused rat liver is dependent on cellular redox potential.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Fasting; Glucagon; In Vitro Techniques; Ketone Bodies; Liver; Male; NAD; NADP; Oxidation-Reduction; Perfusion; Phenylephrine; Rats; Rats, Inbred Strains; Reference Values | 1987 |
Resensitization of hepatocyte glucagon-stimulated adenylate cyclase can be inhibited when cyclic AMP phosphodiesterase inhibitors are used to elevate intracellular cyclic AMP concentrations to supraphysiological values.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclase Inhibitors; Angiotensin II; Animals; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; In Vitro Techniques; Intracellular Fluid; Liver; Male; Rats; Rats, Inbred Strains; Theophylline | 1988 |
Interleukin-1 inhibits glucose-modulated insulin and glucagon secretion in rat islet monolayer cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Female; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Rats; Rats, Inbred WF; Recombinant Proteins | 1988 |
Evidence of cyclic AMP-independent action of glucagon on calcium mobilization in rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Aequorin; Angiotensin II; Animals; Calcium; Colforsin; Cyclic AMP; Glucagon; Liver; Rats; Vasopressins | 1988 |
Control of glucagon-like immunoreactive peptide secretion from fetal rat intestinal cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcimycin; Cells, Cultured; Cobalt; Ethers; Fetus; Gastrointestinal Hormones; Glucagon-Like Peptides; Intestinal Mucosa; Intestines; Ionomycin; Kinetics; Magnesium; Magnesium Chloride; Peptides; Phorbol Esters; Rats; Rats, Inbred Strains | 1988 |
Treatment of intact hepatocytes with the calcium ionophore A23187 perturbs both the synthesis and the degradation of the second messenger cyclic AMP. Actions on adenylate cyclase and cyclic AMP phosphodiesterase activities.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Adenylyl Cyclases; Animals; Calcimycin; Calcium; Cyclic AMP; Glucagon; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains | 1988 |
Monolayer culture of adult rat pancreatic islets on extracellular matrix: long term maintenance of differentiated B-cell function.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Cells, Cultured; Epinephrine; Extracellular Matrix; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Somatostatin; Time Factors | 1988 |
Structure, function, and immunogenicity of human insulinoma cells.
Topics: 1-Methyl-3-isobutylxanthine; Adenoma, Islet Cell; Adult; C-Peptide; Fluorescent Antibody Technique; Glucagon; Glucose; Humans; Insulin; Insulin Secretion; Insulinoma; Lymphocyte Culture Test, Mixed; Lymphocytes; Microscopy, Electron; Pancreatic Neoplasms; Tolbutamide; Tumor Cells, Cultured | 1988 |
Characterization of glucagon and catecholamine effects on isolated sheep hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Calcium; Cell Membrane; Cells, Cultured; Cyclic AMP; Epinephrine; Female; Glucagon; Isoproterenol; Kinetics; Liver; Liver Glycogen; Phentolamine; Phosphorylase a; Propranolol; Rats; Rats, Inbred Strains; Sheep | 1988 |
Beta-cell memory to insulin secretagogues: characterization of the time-dependent inhibitory control system in the isolated rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Dose-Response Relationship, Drug; Epinephrine; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Rats; Time Factors; Tolbutamide | 1989 |
Effect of rise in cAMP levels on Ca2+ influx through voltage-dependent Ca2+ channels in HIT cells. Second-messenger synarchy in beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzofurans; Calcium; Calcium Channels; Cell Line; Cells, Cultured; Colforsin; Cyclic AMP; Electrophysiology; Fura-2; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Second Messenger Systems; Verapamil | 1989 |
Increased cyclic AMP content accelerates protein synthesis in rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbon Radioisotopes; Colforsin; Cyclic AMP; Glucagon; Heart; In Vitro Techniques; Insulin; Kinetics; Male; Myocardial Contraction; Myocardium; Perfusion; Phenylalanine; Protein Biosynthesis; Protein Kinases; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Tetrodotoxin; Theophylline | 1989 |
Glucagon-induced refractoriness of hepatocyte adenylate cyclase: comparison of homologous and heterologous components and evidence against a role of cAMP.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenylyl Cyclases; Animals; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Glucagon; Isoproterenol; Liver; Male; Rats; Rats, Inbred Strains | 1989 |
Reduced early and late phase insulin response to glucose in isolated spiny mouse (Acomys cahirinus) islets: a defective link between glycolysis and adenylate cyclase.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Colforsin; Cyclic AMP; Female; Glucagon; Glucose; Glycolysis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Muridae; Rats; Rats, Inbred Strains | 1989 |
Studies of glucocorticoid enhancement of the capacity of hepatocytes to accumulate cyclic AMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Cyclic AMP; Cycloheximide; Dexamethasone; Glucagon; Glucocorticoids; Isoproterenol; Kinetics; Liver; Male; Methylprednisolone; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Strains | 1989 |
Contribution by the glycogen pool and adenosine 3',5'-monophosphate release to the evanescent effect of glucagon on hepatic glucose production in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Erythrocytes; Glucagon; Glucose; Glycogen; In Vitro Techniques; Lactates; Liver; Male; Models, Biological; Rats; Rats, Inbred Strains | 1985 |
Forskolin, an activator of adenylate cyclase, stimulates pancreatic insulin, glucagon, and somatostatin release in the dog: studies in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Atropine; Calcium; Colforsin; Diterpenes; Dogs; Dose-Response Relationship, Drug; Enzyme Activation; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Pancreas; Phentolamine; Propranolol; Somatostatin | 1985 |
Studies on the mechanism of action of glucagon in strips of rabbit renal artery.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic AMP; Female; Glucagon; In Vitro Techniques; Indomethacin; Male; Papaverine; Phosphodiesterase Inhibitors; Proadifen; Rabbits; Renal Artery; Theophylline; Vasodilator Agents; Verapamil | 1980 |
Induction of DNA synthesis in adult rat hepatocytes cultured in a serum-free medium.
Topics: 1-Methyl-3-isobutylxanthine; Amiloride; Animals; Cell Division; Cells, Cultured; Culture Media; Cyclic AMP; DNA; Glucagon; Insulin; Liver; Liver Regeneration; Rats; Sodium | 1980 |
Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Cyclic AMP; Enzyme Reactivators; Epinephrine; Glucagon; Isoproterenol; Kinetics; Male; Myocardium; Prostaglandins; Rats; Receptors, Cyclic AMP | 1981 |
Nutrient-induced priming of insulin and glucagon secretion. Effects of alpha-ketoisocaproic acid.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Caproates; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Male; Rats; Rats, Inbred Strains | 1982 |
Functional differences between rat islets of ventral and dorsal pancreatic origin.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; B-Lymphocytes; Cyclic AMP; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Pancreatic Polypeptide; Proinsulin; Rats; Rats, Inbred Strains | 1982 |
The interaction of glucagon, gastric inhibitory peptide and somatostatin with cyclic AMP production systems present in rat gastric glands.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Gastric Inhibitory Polypeptide; Gastric Mucosa; Gastrointestinal Hormones; Glucagon; Kinetics; Male; Microscopy, Electron; Rats; Rats, Inbred Strains; Somatostatin; Stomach | 1982 |
Modulation by thyroid status of the actions of glucagon and dibutyryl adenosine 3',5'-monophosphate on metabolism of free fatty acids by the isolated perfused rat liver.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Fatty Acids, Nonesterified; Glucagon; Kinetics; Liver; Male; Propylthiouracil; Rats; Rats, Inbred Strains; Thyroid Gland; Triglycerides; Triiodothyronine | 1982 |
Ontogeny of glucagon and isoproterenol induced cyclic 3'-5' adenosine monophosphate production in adipocytes isolated from the inguinal adipose tissue of developing rats.
Topics: 1-Methyl-3-isobutylxanthine; Adipose Tissue; Age Factors; Animals; Animals, Newborn; Cyclic AMP; Glucagon; In Vitro Techniques; Isoproterenol; Rats; Receptors, Adrenergic, beta | 1982 |
Modulation by IBMX, fasting and experimental diabetes of glibenclamide-induced islet hormone release from the perfused rat pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fasting; Glucagon; Glyburide; Insulin; Insulin Secretion; Male; Pancreas; Pancreatic Hormones; Rats; Rats, Inbred Strains; Somatostatin; Theophylline | 1983 |
Requirement of prolonged presence of a high intracellular level of cyclic AMP for induction of serine dehydratase in primary cultured rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Cyclic AMP; Dexamethasone; Enzyme Induction; Glucagon; Isoproterenol; L-Serine Dehydratase; Liver; Protein Kinases | 1983 |
L-leucine methyl ester stimulates insulin secretion and islet glutamate dehydrogenase.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Glucagon; Glucose; Glutamate Dehydrogenase; Glutamine; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Leucine; Male; Mice; Mice, Inbred Strains; Norepinephrine; Pancreatic Neoplasms; Rats | 1983 |
Hormone release by islet B cell-enriched and A and D cell-enriched populations prepared by flow cytometry.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Flow Cytometry; Glucagon; Glucose; Glyburide; Insulin; Islets of Langerhans; Male; Rats; Rats, Inbred Strains | 1983 |
In vitro regulation of human monocyte insulin receptors by insulin and 1-methyl-3-isobutylxanthine.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Bucladesine; Cyclic AMP; Glucagon; Humans; Insulin; Kinetics; Monocytes; Receptor, Insulin; Receptors, Cell Surface; Receptors, Glucagon; Theophylline | 1983 |
Calmodulin and cyclic AMP. Possible different sites of action of these two regulatory agents in exocytotic hormone release.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calmodulin; Colforsin; Cyclic AMP; Diterpenes; Exocytosis; Glucagon; Glucose; Hormones; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, Somatostatin; Somatostatin | 1984 |
Dispersed adult rat pancreatic islet cells in culture: A, B, and D cell function.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Culture Techniques; Glucagon; Glucose; Insulin; Islets of Langerhans; Male; Microscopy, Electron; Proinsulin; Rats; Rats, Inbred Strains; Somatostatin | 1984 |
Is somatostatin a true local inhibitory regulator of insulin secretion?
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cysteamine; Cytoplasmic Granules; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Somatostatin | 1984 |
PGE1-independent MDCK cells have elevated intracellular cyclic AMP but retain the growth stimulatory effects of glucagon and epidermal growth factor in serum-free medium.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Bucladesine; Cell Division; Cell Line; Culture Media; Cyclic AMP; Dogs; Epidermal Growth Factor; Glucagon; Kidney; Prostaglandins E | 1984 |
Induction of fructose 1,6-bisphosphatase and glucose 6-phosphatase by dibutyryl cyclic adenosine monophosphate in fetal mouse liver.
Topics: 1-Methyl-3-isobutylxanthine; Alprostadil; Animals; Bucladesine; Butyrates; Butyric Acid; Enzyme Induction; Female; Fetus; Fructose-Bisphosphatase; Glucagon; Glucose-6-Phosphatase; Hormones; Isoproterenol; Kinetics; Liver; Mice; Mice, Inbred ICR; Organ Culture Techniques; Pregnancy; Prostaglandins E | 1984 |
Nifedipine and nicardipine potentiate glucagon-stimulated glycogenolysis in primary cultures of rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Caffeine; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Glucagon; Glycogen; Liver; Male; Nicardipine; Nifedipine; Papaverine; Rats; Rats, Wistar | 1993 |
The augmentation of insulin-like growth factor-I messenger ribonucleic acid in cultured rat hepatocytes: activation of protein kinase-A and -C is necessary, but not sufficient.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Alkaloids; Animals; Blotting, Northern; Bucladesine; Cattle; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Drug Synergism; Enzyme Activation; Glucagon; Growth Hormone; Insulin-Like Growth Factor I; Isoquinolines; Kinetics; Liver; Male; Piperazines; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sphingosine; Staurosporine; Tetradecanoylphorbol Acetate | 1994 |
Effect of nutrients, hormones and serum on survival of rat islet beta cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood; Cell Survival; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Glucagon; Glucose; Glutamine; Growth Hormone; Hormones; Insulin; Insulin-Like Growth Factor I; Islets of Langerhans; Leucine; Male; Monosaccharides; Rats; Rats, Wistar; Serum Albumin, Bovine | 1994 |
Amylin (islet amyloid polypeptide) inhibition of insulin release in the perfused rat pancreas: implication of the adenylate cyclase/cAMP system.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Amyloid; Animals; Colforsin; Cyclic AMP; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Insulin Secretion; Islet Amyloid Polypeptide; Islets of Langerhans; Male; Perfusion; Rats; Rats, Wistar | 1994 |
Preservation of glucose-responsive islet beta-cells during serum-free culture.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood; Cell Degranulation; Cell Survival; Cells, Cultured; Culture Media; DNA; Glucagon; Glucose; Glutamine; Insulin; Islets of Langerhans; Male; Microscopy, Electron; Proinsulin; Rats; Rats, Wistar; Serum Albumin, Bovine | 1994 |
The regulation of insulin-like growth factor-binding protein 1 messenger ribonucleic acid in cultured rat hepatocytes: the roles of glucagon and growth hormone.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Carrier Proteins; Cells, Cultured; Cyclic AMP; Densitometry; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation; Glucagon; Growth Hormone; Insulin-Like Growth Factor Binding Protein 1; Liver; Male; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Morphological and functional characterization of beta TC-6 cells--an insulin-secreting cell line derived from transgenic mice.
Topics: 1-Methyl-3-isobutylxanthine; Analysis of Variance; Animals; Antigens, Polyomavirus Transforming; Cell Line; Epinephrine; Glucagon; Glucose; GTP-Binding Proteins; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Mice; Mice, Transgenic; Microscopy, Confocal; NAD; Perfusion; Pertussis Toxin; Radioimmunoassay; Simian virus 40; Somatostatin; Virulence Factors, Bordetella | 1995 |
Regulation of glucagon and glucagon-like peptide-1 receptor messenger ribonucleic acid expression in cultured rat pancreatic islets by glucose, cyclic adenosine 3',5'-monophosphate, and glucocorticoids.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Dexamethasone; Dose-Response Relationship, Drug; Gene Expression Regulation; Glucagon; Glucagon-Like Peptide 1; Glucose; Islets of Langerhans; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Receptors, Glucagon; Ribonucleases; RNA, Messenger | 1995 |
Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antigens, Polyomavirus Transforming; Bucladesine; Cholera Toxin; Colforsin; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Intestinal Neoplasms; Mice; Mice, Nude; Mice, Transgenic; Microscopy, Electron; Neoplasm Transplantation; Peptide Fragments; Proglucagon; Protein Precursors; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1994 |
Regulation of glucagon receptor mRNA in cultured primary rat hepatocytes by glucose and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Cyclic AMP; Gene Expression Regulation; Glucagon; Glucose; Isoproterenol; Liver; Male; Rats; Rats, Wistar; Receptors, Glucagon; RNA, Messenger | 1995 |
VIP inhibits basal and histamine-stimulated proliferation of human airway smooth muscle cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Carbazoles; Cell Cycle; Cell Division; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA; Dose-Response Relationship, Drug; Glucagon; Histamine; Histamine Antagonists; Humans; Indoles; Kinetics; Muscle, Smooth; Pyrroles; Thymidine; Trachea; Vasoactive Intestinal Peptide | 1995 |
Hormone stimulation of type III adenylyl cyclase induces Ca2+ oscillations in HEK-293 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cell Line; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; Glucagon; Humans; Inositol 1,4,5-Trisphosphate Receptors; Isoproterenol; Isoquinolines; Kidney; Kinetics; Models, Biological; Oscillometry; Phosphatidylinositols; Piperazines; Receptors, Cytoplasmic and Nuclear; Receptors, Glucagon; Signal Transduction; Time Factors | 1995 |
Multiple cis-acting domains mediate basal and adenosine 3',5'-monophosphate-dependent glucagon gene transcription in a mouse neuroendocrine cell line.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Cell Line; Chloramphenicol O-Acetyltransferase; Colforsin; Cyclic AMP; Glucagon; Intestinal Neoplasms; Mice; Mice, Transgenic; Neurosecretory Systems; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1993 |
Paradoxical release of insulin by adult pig islets in vitro. Recovery after culture in a defined tissue culture medium.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Culture Media, Serum-Free; Dose-Response Relationship, Drug; Glucagon; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Swine; Time Factors | 1993 |
Protein kinase C activation and positive and negative agonist regulation of 3',5'-cyclic adenosine monophosphate levels in cultured rat Sertoli cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Activation; Follicle Stimulating Hormone; Glucagon; Isoproterenol; Male; Phenylisopropyladenosine; Protein Kinase C; Rats; Sertoli Cells; Tetradecanoylphorbol Acetate | 1993 |
Dual actions of glucagon: direct stimulation and indirect inhibition of dog pancreatic secretion.
Topics: 1-Methyl-3-isobutylxanthine; Anesthesia; Animals; Bicarbonates; Dogs; Dose-Response Relationship, Drug; Female; Glucagon; In Vitro Techniques; Male; Pancreas; Pancreatic Juice; Proteins; Secretin; Sincalide; Somatostatin | 1993 |
cAMP and protein synthesis in isolated adult rat heart preparations.
Topics: 1-Methyl-3-isobutylxanthine; Adenine Nucleotides; Animals; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Energy Metabolism; Epinephrine; Glucagon; Heart; Hypertension; In Vitro Techniques; Isoproterenol; Kinetics; Male; Myocardium; Perfusion; Phenylephrine; Phosphocreatine; Prazosin; Propranolol; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Yohimbine | 1993 |
Inhibition of protein kinase A-induced glucagon synthesis and secretion by glucose.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Citrates; Citric Acid; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucose; Male; Rats; Streptozocin | 1996 |
A role of asialoglycoproteins for plasma-membrane-induced inhibition of the switching from alpha 1 to beta subtypes in adrenergic response during primary culture of rat hepatocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aging; Animals; Asialoglycoproteins; beta-Galactosidase; Cell Division; Cell Membrane; Cells, Cultured; Cyclic AMP; Glucagon; Glycoside Hydrolases; Inositol 1,4,5-Trisphosphate; Isoproterenol; Kinetics; Liver; Membrane Glycoproteins; Neuraminidase; Phenylephrine; Rats; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta | 1996 |
Glucagon-like peptide-1(7-36)amide enhances insulin-stimulated glucose uptake and decreases intracellular cAMP content in isolated rat adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Animals; Colforsin; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Glucose; Insulin; Male; Peptide Fragments; Peptides; Phosphodiesterase Inhibitors; Rats | 1996 |
Impaired cyclic AMP response to stimuli in glucose-desensitized rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Drug Synergism; Drug Tolerance; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Protein Precursors; Rats; Rats, Sprague-Dawley | 1995 |
The glucose sensor protein glucokinase is expressed in glucagon-producing alpha-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Base Sequence; Brain; Cells, Cultured; DNA Primers; DNA, Complementary; Glucagon; Glucagonoma; Glucokinase; Glucose; Glucose Transporter Type 2; Glutamine; Homeostasis; Insulin; Islets of Langerhans; Liver; Male; Molecular Sequence Data; Monosaccharide Transport Proteins; Pancreatic Neoplasms; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Low level cyclic adenosine 3',5'-monophosphate accumulation analysis of [des-His1, des- Phe6, Glu9] glucagon-NH2 identifies glucagon antagonists from weak partial agonists/antagonists.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclase Inhibitors; Amrinone; Animals; Blood Glucose; Cyclic AMP; Diabetes Mellitus, Experimental; Glucagon; Liver; Male; Phosphodiesterase Inhibitors; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Rolipram | 1996 |
Glucagon-like peptide-1(7-36)amide and cytoplasmic calcium in insulin producing cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cytoplasm; Fura-2; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Insulin; Insulinoma; Islets of Langerhans; Male; Neurotransmitter Agents; Peptide Fragments; Phosphodiesterase Inhibitors; Protein Precursors; Rats; Rats, Sprague-Dawley; Sincalide; Tumor Cells, Cultured | 1996 |
Decreased glucose-induced cAMP and insulin release in islets of diabetic rats: reversal by IBMX, glucagon, GIP.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Brimonidine Tartrate; Cyclic AMP; Diabetes Mellitus, Experimental; Dinoprostone; Galanin; Gastric Inhibitory Polypeptide; Glucagon; Insulin; Insulin Secretion; Islets of Langerhans; Quinoxalines; Rats; Rats, Wistar; Secretory Rate; Somatostatin | 1996 |
Effect of PACAP, VIP, glucagon, and GLP1 on cAMP production and insulin release of HIT-T15 cells is passage dependent.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cell Line; Cell Line, Transformed; Colforsin; Cricetinae; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Neuropeptides; Neurotransmitter Agents; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Protein Precursors; Swine; Vasoactive Intestinal Peptide | 1996 |
Glucokinase regulatory protein may interact with glucokinase in the hepatocyte nucleus.
Topics: 1-Methyl-3-isobutylxanthine; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Compartmentation; Cell Nucleus; Fructose; Glucagon; Glucokinase; Humans; Immunoenzyme Techniques; Intracellular Signaling Peptides and Proteins; Liver; Male; Proteins; Rats; Rats, Sprague-Dawley | 1997 |
Regulation of glycosylphosphatidylinositol-specific phospholipase D secretion from beta TC3 cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cycloheximide; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Immunohistochemistry; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Kinetics; Mice; Pancreatic Neoplasms; Peptide Fragments; Phospholipase D; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1997 |
Protein kinase A-dependent stimulation of exocytosis in mouse pancreatic beta-cells by glucose-dependent insulinotropic polypeptide.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cell Membrane; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Electric Conductivity; Enzyme Inhibitors; Exocytosis; Gastric Inhibitory Polypeptide; Gastrointestinal Hormones; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Peptide Fragments; Phosphodiesterase Inhibitors; Tetradecanoylphorbol Acetate; Thionucleotides | 1997 |
cAMP-mediated c-fos expression in pressure-overloaded acceleration of protein synthesis in adult rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blotting, Northern; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Gene Expression; Genes, fos; Glucagon; Isoquinolines; Male; Perfusion; Phosphodiesterase Inhibitors; Pressure; Protein Biosynthesis; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sulfonamides | 1997 |
Mechanism of the impairment of the glucagon-stimulated phosphoenolpyruvate carboxykinase gene expression by interleukin-6 in rat hepatocytes: inhibition of the increase in cyclic 3',5' adenosine monophosphate and the downstream cyclic 3',5' adenosine mono
Topics: 1-Methyl-3-isobutylxanthine; Adenylate Cyclase Toxin; Animals; Cells, Cultured; Colforsin; Cyclic AMP; Gene Expression Regulation, Enzymologic; Genes, Reporter; Glucagon; Interleukin-6; Liver; Male; Pertussis Toxin; Phosphoenolpyruvate Carboxykinase (GTP); Rats; Rats, Wistar; RNA, Messenger; Time Factors; Transfection; Virulence Factors, Bordetella | 1997 |
Salutary effects of ATP-MgCl2 on altered hepatocyte signal transduction after hemorrhagic shock.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Analysis of Variance; Animals; Cells, Cultured; Cyclic AMP; Glucagon; Inositol 1,4,5-Trisphosphate; Liver; Male; Rats; Rats, Sprague-Dawley; Receptors, Glucagon; Receptors, Vasopressin; Resuscitation; Shock, Hemorrhagic; Signal Transduction; Vasopressins | 1997 |
Cyclic AMP, a mediator of GLP-1, acts in concert with glucose and tolbutamide to increase cytosolic Ca2+ in pancreatic B-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Cells, Cultured; Colforsin; Cyclic AMP; Cytosol; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Islets of Langerhans; Peptide Fragments; Potassium Chloride; Rats; Rats, Wistar; Tolbutamide | 1997 |
GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbachol; Cell Line; Cloning, Molecular; Cyclic AMP; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycogen; Glycolysis; Insulin; Kinetics; Muscle, Skeletal; Pancreas; Peptide Fragments; Protein Precursors; Rats; Receptors, Glucagon; Recombinant Proteins; Transfection; Venoms | 1998 |
Pressure-induced expression of heat shock protein 70 mRNA in adult rat heart is coupled both to protein kinase A-dependent and protein kinase C-dependent systems.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Pressure; Cardiomegaly; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Gene Expression; Glucagon; HSP70 Heat-Shock Proteins; Hypertension; In Vitro Techniques; Isoquinolines; Male; Myocardium; Naphthalenes; Perfusion; Protein Biosynthesis; Protein Kinase C; Rats; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Sulfonamides | 1998 |
Regulatable production of insulin from primary-cultured hepatocytes: insulin production is up-regulated by glucagon and cAMP and down-regulated by insulin.
Topics: 1-Methyl-3-isobutylxanthine; Adenoviridae; Androstadienes; Animals; Cells, Cultured; Cyclic AMP; Gene Expression Regulation; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Glucagon; Insulin; Insulin Antagonists; Liver; Male; Phosphoenolpyruvate Carboxykinase (GTP); Proinsulin; Rats; Rats, Wistar; Wortmannin | 1998 |
Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Carbachol; Colforsin; Cyclic AMP; Fasting; Female; Food Deprivation; Gastrectomy; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred Strains; Parietal Cells, Gastric; Rats; Stomach; Tissue Extracts; Vagotomy | 1999 |
Evaluation of immunoisolated insulin-secreting beta TC6-F7 cells as a bioartificial pancreas.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Capsules; Cell Division; Cell Separation; Diabetes Mellitus, Experimental; Glucagon; Glucagon-Like Peptide 1; Glucose Tolerance Test; Insulin; Insulin Secretion; Insulinoma; Pancreas, Artificial; Pancreatic Neoplasms; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Time Factors; Tumor Cells, Cultured | 1997 |
Effects of cryopreservation on in vitro and in vivo long-term function of human islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Cryopreservation; Diabetes Mellitus, Experimental; Glucagon; Glucose; Glucose Tolerance Test; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Islets of Langerhans Transplantation; Male; Mice; Mice, Nude; Reference Values; Time Factors; Transplantation, Heterologous | 1999 |
Nitric oxide and hydroperoxide affect islet hormone release and Ca(2+) efflux.
Topics: 1-Methyl-3-isobutylxanthine; Animals; ATP-Binding Cassette Transporters; Calcium; Catalase; Cyclic AMP; Enzyme Inhibitors; Free Radicals; Glucagon; Glucose; Glutathione Peroxidase; Hydrogen Peroxide; Insulin; Insulin Secretion; Islets of Langerhans; KATP Channels; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidants; Potassium Channels; Potassium Channels, Inwardly Rectifying | 1999 |
The cyclic AMP-protein kinase A pathway restrains islet phospholipase A(2) activation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Carbachol; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Gastric Inhibitory Polypeptide; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Melitten; Peptide Fragments; Phospholipases A; Protein Precursors; Rats; Rats, Sprague-Dawley; Signal Transduction; Sincalide; Vasoactive Intestinal Peptide | 2000 |
Regulation of the diabetes-associated autoantigen IA-2 in INS-1 pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Autoantigens; Colforsin; Cyclic AMP; Gene Expression Regulation; Glucagon; Glucose; Insulinoma; Islets of Langerhans; Kinetics; Membrane Proteins; Pancreatic Neoplasms; Protein Kinase C; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Receptor-Like Protein Tyrosine Phosphatases, Class 8; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 2000 |
Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Binding Sites; Colforsin; Cyclic AMP; Cyclic AMP Response Element Modulator; Diabetes Mellitus; DNA; DNA-Binding Proteins; Female; Gene Expression; Glucagon; Glucagon-Like Peptide 1; Insulin; Islets of Langerhans; Male; Neuropeptides; Peptide Fragments; Pituitary Adenylate Cyclase-Activating Polypeptide; Promoter Regions, Genetic; Protein Precursors; Rats; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2000 |
Insulin increased cAMP phosphodiesterase activity antagonizing metabolic actions of glucagon in rat hepatocytes cultured with herbimycin A.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Benzoquinones; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 4; Dose-Response Relationship, Drug; Enzyme Activation; Glucagon; Hepatocytes; Insulin; Lactams, Macrocyclic; Male; Microtubules; Phosphatidylinositol 3-Kinases; Phosphorylases; Phosphorylation; Quinones; Rats; Rats, Wistar; Rifabutin; Tubulin; Tyrosine | 2000 |
Coregulation of glucagon-like peptide-1 synthesis with proglucagon and prohormone convertase 1 gene expression in enteroendocrine GLUTag cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Aspartic Acid Endopeptidases; Cell Line; Colforsin; Gene Expression Regulation; Genes, Reporter; Glucagon; Glucagon-Like Peptide 1; Intestinal Mucosa; Kinetics; Luciferases; Mice; Peptide Fragments; Proglucagon; Proprotein Convertase 1; Proprotein Convertases; Protein Precursors; Rats; Recombinant Fusion Proteins; RNA, Messenger; Transcription, Genetic; Transfection | 2001 |
Effect of GLP-1 on lipid metabolism in human adipocytes.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Cyclic AMP; Dose-Response Relationship, Drug; Female; Glucagon; Glucagon-Like Peptide 1; Humans; Lipid Metabolism; Lipids; Lipolysis; Male; Middle Aged; Peptide Fragments; Protein Precursors | 2001 |
The antilipolytic agent 3,5-dimethylpyrazole inhibits insulin release in response to both nutrient secretagogues and cyclic adenosine monophosphate agonists in isolated rat islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Diglycerides; Glucagon; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Lipolysis; Male; Nutritional Physiological Phenomena; Pyrazoles; Rats; Rats, Sprague-Dawley | 2002 |
Triggering of insulin release by a combination of cAMP signal and nutrients: an ATP-sensitive K+ channel-independent phenomenon.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Calcium; Colforsin; Cyclic AMP; Diazoxide; Glucagon; Glucagon-Like Peptide 1; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Peptide Fragments; Phosphodiesterase Inhibitors; Potassium Channels; Protein Precursors; Rats; Rats, Wistar; Signal Transduction; Sodium Azide; Vasodilator Agents | 2002 |
Correlation between GABA release from rat islet beta-cells and their metabolic state.
Topics: 1-Methyl-3-isobutylxanthine; 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Calcium; Culture Media, Conditioned; Cycloheximide; Diazoxide; gamma-Aminobutyric Acid; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamate Decarboxylase; Glyburide; Islets of Langerhans; Male; Mannoheptulose; Oxidation-Reduction; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Verapamil | 2002 |
Total parenteral nutrition modulates hormone release by stimulating expression and activity of inducible nitric oxide synthase in rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cyclic AMP; Cyclic GMP; Glucagon; Glucose; Hormones; In Vitro Techniques; Injections, Intravenous; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Parenteral Nutrition, Total; Rats; Rats, Sprague-Dawley; Reference Values | 2001 |
Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Colforsin; Fatty Acids; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Lipolysis; Male; Peptide Fragments; Phosphofructokinase-2; Protein Precursors; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2003 |
Time-dependent stimulation of insulin exocytosis by 3',5'-cyclic adenosine monophosphate in the rat islet beta-cell.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Bucladesine; Calcium; Cerulenin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Exocytosis; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Membrane Potentials; Peptide Fragments; Potassium; Protein Precursors; Rats; Rats, Wistar | 2002 |
Leptin constrains phospholipase C-protein kinase C-induced insulin secretion via a phosphatidylinositol 3-kinase-dependent pathway.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Androstadienes; Animals; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Glucagon; Glucagon-Like Peptide 1; Insulin; Insulin Secretion; Islets of Langerhans; Leptin; Mice; Mice, Inbred C57BL; Mice, Knockout; Peptide Fragments; Phosphatidylinositol 3-Kinases; Phosphodiesterase Inhibitors; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Precursors; Signal Transduction; Type C Phospholipases; Wortmannin | 2003 |
Islet amyloid polypeptide inhibits glucagon release and exerts a dual action on insulin release from isolated islets.
Topics: 1-Methyl-3-isobutylxanthine; Amyloid; Animals; Arginine; Carbachol; Cholinergic Agonists; Culture Media; Female; Glucagon; Glucose; Insulin; Insulin Secretion; Islet Amyloid Polypeptide; Islets of Langerhans; Mice; Phosphodiesterase Inhibitors | 2003 |
Restitution of defective glucose-stimulated insulin release of sulfonylurea type 1 receptor knockout mice by acetylcholine.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; ATP-Binding Cassette Transporters; Blood Glucose; Calcium; Glucagon; Glucagon-Like Peptide 1; In Vitro Techniques; Insulin; Insulin Secretion; Intracellular Fluid; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Mice, Knockout; Multidrug Resistance-Associated Proteins; Peptide Fragments; Phosphodiesterase Inhibitors; Potassium Channels, Inwardly Rectifying; Protein Precursors; Receptors, Drug; Second Messenger Systems; Signal Transduction; Sulfonylurea Receptors | 2004 |
Effects of ghrelin on insulin and glucagon secretion: a study of isolated pancreatic islets and intact mice.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Arginine; Blood Glucose; Carbachol; Dose-Response Relationship, Drug; Female; Ghrelin; Glucagon; Glucose; Glucose Tolerance Test; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Pancreas; Peptide Hormones; Signal Transduction; Time Factors | 2004 |
Regulation of alpha-cell function by the beta-cell in isolated human and rat islets deprived of glucose: the "switch-off" hypothesis.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Diabetes Mellitus, Experimental; Drug Administration Schedule; Glucagon; Glucose; Humans; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Models, Biological; Rats | 2004 |
The rat pancreatic islets: a reliable tool to study islet responses to cholecystokinin receptor occupation.
Topics: 1-Methyl-3-isobutylxanthine; Adult; Animals; Blotting, Western; Colforsin; Fetus; Glucagon; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Microscopy, Confocal; Rats; Receptors, Cholecystokinin; Receptors, Somatostatin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Somatostatin | 2004 |
Characterization of human islet-like structures generated from pancreatic precursor cells in culture.
Topics: 1-Methyl-3-isobutylxanthine; C-Peptide; Cell Count; Cell Proliferation; Cells, Cultured; Culture Media; Culture Media, Serum-Free; Gene Expression; Glucagon; Glucose; Homeodomain Proteins; Humans; Insulin; Islets of Langerhans; Pancreatic Polypeptide; Reverse Transcriptase Polymerase Chain Reaction; Somatostatin; Stem Cells; Tissue Culture Techniques; Tissue Engineering; Trans-Activators | 2006 |
Glucagon increases contractility in ventricle but not in atrium of the rat heart.
Topics: 1-Methyl-3-isobutylxanthine; Actins; Animals; Blotting, Western; Cardiotonic Agents; Electric Stimulation; Female; Glucagon; Heart; Heart Atria; Heart Ventricles; Isoproterenol; Male; Myocardial Contraction; Pertussis Toxin; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley | 2008 |
Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Glucagon; Heart; Heart Atria; Heart Rate; Humans; Myocardial Contraction; Rats; Receptors, Glucagon | 2023 |