gliclazide has been researched along with tolbutamide in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (18.52) | 18.7374 |
| 1990's | 18 (33.33) | 18.2507 |
| 2000's | 8 (14.81) | 29.6817 |
| 2010's | 16 (29.63) | 24.3611 |
| 2020's | 2 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Barber, J; Dawson, S; Kenna, JG; Paul, N; Stahl, S | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Kato, Y; Maekawa, H; Sekiya, A; Yamamoto, J | 1 |
| Balabolkin, MI; Danilova, TI; Ol'shanskaia, AA; Timofeev, AV; Zhuleva, LIu | 1 |
| Ambrosi, F; Cristallini, S; Filipponi, P; Gregorio, F; Pedetti, M; Santeusanio, F | 1 |
| Harrower, AD | 1 |
| Aranyi, Z; Ballagi-Pordány, G; Koltai, MZ; Köszeghy, A; Pogátsa, G | 1 |
| Katsumata, K; Katsumata, Y | 1 |
| Boutagy, JS; Shenfield, GM; Webb, C | 1 |
| Gram, J; Jespersen, J; Kold, A | 1 |
| Gagliardino, JJ; Gronda, CM; Rossi, JP | 1 |
| Baba, S; Yokono, K; Zeng, SF | 1 |
| Malaisse, WJ; Malaisse-Lagae, F; Mathias, PC; Sener, A | 1 |
| Hatao, K; Kaku, K; Kaneko, T; Matsuda, M; Tsuchiya, M | 1 |
| Anjaneyulu, K; Anjaneyulu, R; Couturier, E; Malaisse, WJ | 1 |
| Brasseur, R; Deleers, M; Gelbcke, M; Malaisse, WJ | 1 |
| Berber, MJ; Tomkin, GH | 1 |
| Arfors, KE; Bergqvist, D; Tangen, O | 1 |
| Kruseman, AC; Menheere, PP; Müller, PG; Nijst, L; Sels, JP; Wolffenbuttel, BH | 1 |
| Katsumata, K; Katsumata, Y; Ozawa, T | 1 |
| Gross, AS; Rieutord, A; Shenfield, GM; Stupans, I | 1 |
| Selvaag, E | 1 |
| Fujitani, S; Okazaki, K; Yada, T | 1 |
| Gagliardino, JJ; García, ME; Rossi, PF | 1 |
| Awata, T; Inoue, I; Katayama, S; Negishi, K; Noji, S; Takahashi, K | 1 |
| Abenhaim, L; Monette, J; van Staa, T | 1 |
| Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A | 1 |
| Luo, M; O'Brien, RC | 1 |
| Bataille, D; Blache, P; Gros, L; Salazar, G; Virsolvy, A | 1 |
| Ashcroft, FM; Gribble, FM | 1 |
| de Smet, PA; Fischer, HR | 1 |
| Arcelloni, C; Beck-Peccoz, P; Brocco, S; Ciucci, A; Comuzzi, B; de Kreutzenberg, S; Genovese, S; Paroni, R; Tiengo, A | 1 |
| Ashcroft, SJ; Mikhailov, MV; Mikhailova, EA | 1 |
| Albinson, SL; Ashcroft, FM; Lippiat, JD | 1 |
| Bae, JH; Cho, CH; Han, J; Jang, BC; Kim, SP; Kim, SS; Lee, HY; Lim, JG; Park, JW; Park, MJ; Song, DK; Suh, SI; Yun, JE | 1 |
| Feng, CH; Lu, CY; Yang, CM | 1 |
| Aguilar-Bryan, L; Bryan, J; Drews, G; Düfer, M; Gier, B; Krippeit-Drews, P; Sheiko, T | 1 |
| Abdelmoneim, AS; Brocks, DR; Hasenbank, SE; Light, PE; Seubert, JM; Simpson, SH | 1 |
| Fatehi, M; Lang, VY; Light, PE | 1 |
| Broderick, HJ; Guerra, ML; Hockerman, GH; Jarrard, RE; Lange, AM; Pratt, EP; Salyer, AE; Soderling, IM; Wang, Y | 1 |
| Bo, S; Castiglione, A; Cavallo-Perin, P; Ciccone, G; Durazzo, M; Gentile, L; Ghigo, E | 1 |
| Andersson, C; Fosbøl, EL; Gislason, G; Køber, L; Mogensen, UM; Scheller, NM; Schramm, TK; Torp-Pedersen, C; Vaag, A | 1 |
| Dansk, H; Grapengiesser, E; Hellman, B | 1 |
| Azoulay, L; Douros, A; Filion, KB; Suissa, S; Yin, H; Yu, OHY | 1 |
| Barroso Oquendo, M; Drews, G; Krippeit-Drews, P; Layer, N; Wagner, R | 1 |
| Eggert, F; Elgert, C; Früh, E; Rustenbeck, I; Scherneck, S | 1 |
| Chae, H; Desmet, L; Gilon, P; Herrera, PL; Khattab, F; Singh, B | 1 |
| Edwards, TM; Verwey, LJ | 1 |
2 review(s) available for gliclazide and tolbutamide
| Article | Year |
|---|---|
[Timing of administration of sulfonyl urea derivatives].
Topics: Biological Availability; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Tolbutamide | 2000 |
Variations in tissue selectivity amongst insulin secretagogues: a systematic review.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Cardiovascular Diseases; Cricetinae; Cyclohexanes; Diabetes Mellitus, Type 2; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial; Isoindoles; Mice; Muscle, Smooth, Vascular; Myocytes, Cardiac; Nateglinide; Phenylalanine; Piperidines; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Risk Factors; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
4 trial(s) available for gliclazide and tolbutamide
| Article | Year |
|---|---|
Efficacy of gliclazide in comparison with other sulphonylureas in the treatment of NIDDM.
Topics: Blood Glucose; Chlorpropamide; Diabetes Mellitus, Type 2; Diet, Diabetic; Gliclazide; Glipizide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Tolbutamide | 1991 |
The effects of gliclazide in diabetes: a comparison with tolbutamide.
Topics: Blood Glucose; Clinical Trials as Topic; Diabetes Mellitus; Gliclazide; Humans; Lipids; Sulfonylurea Compounds; Tolbutamide | 1982 |
Effects of a new oral hypoglycaemic agent, repaglinide, on metabolic control in sulphonylurea-treated patients with NIDDM.
Topics: Aged; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Female; Fructosamine; Gliclazide; Glyburide; Glycated Hemoglobin; Hexosamines; Humans; Hypoglycemic Agents; Lipids; Male; Middle Aged; Piperidines; Tolbutamide | 1993 |
Acarbose controls postprandial hyperproinsulinemia in non-insulin dependent diabetes mellitus.
Topics: Acarbose; Aged; Blood Glucose; C-Peptide; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Fasting; Gliclazide; Glucose Intolerance; Glycated Hemoglobin; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Middle Aged; Postprandial Period; Proinsulin; Time Factors; Tolbutamide; Triglycerides; Trisaccharides | 1997 |
48 other study(ies) available for gliclazide and tolbutamide
| Article | Year |
|---|---|
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Cholestasis; Drug-Related Side Effects and Adverse Reactions; Humans; Insecta; Rats; Risk Factors | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
[Effects of oral hypoglycemic agents, gliclazide and tolbutamide, on the cardiovascular system (author's transl)].
Topics: Animals; Blood Flow Velocity; Blood Glucose; Blood Pressure; Cardiovascular System; Coronary Vessels; Dose-Response Relationship, Drug; Female; Gliclazide; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Male; Muscle Tonus; Myocardial Contraction; Rabbits; Rats; Sulfonylurea Compounds; Tolbutamide | 1978 |
[The insulin-secreting and proliferative activity of established islet cells in the presence of sulfonylurea].
Topics: Animals; Cell Division; Cell Line; Cell Line, Transformed; Cells, Cultured; Cricetinae; Gliclazide; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1992 |
Therapeutical concentrations of tolbutamide, glibenclamide, gliclazide and gliquidone at different glucose levels: in vitro effects on pancreatic A- and B-cell function.
Topics: Animals; Blood Glucose; Dose-Response Relationship, Drug; Gliclazide; Glucagon; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Perfusion; Rats; Rats, Sprague-Dawley; Sulfonylurea Compounds; Time Factors; Tolbutamide | 1992 |
Divergent cardiac effects of the first and second generation hypoglycemic sulfonylurea compounds.
Topics: Animals; Arrhythmias, Cardiac; Blood Glucose; Carbutamide; Dose-Response Relationship, Drug; Electrocardiography; Gliclazide; Glipizide; Glyburide; Hypoglycemic Agents; Male; Myocardial Infarction; Potassium; Rats; Rats, Inbred Strains; Reference Values; Structure-Activity Relationship; Tolbutamide | 1990 |
The potentiating effect of the simultaneous administration of tolbutamide, glibenclamide, and gliclazide on the development of alloxan-induced diabetes in rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drug Synergism; Gliclazide; Glucose Tolerance Test; Glyburide; Insulin; Male; Pancreas; Rats; Rats, Inbred Strains; Sulfonylurea Compounds; Tolbutamide | 1990 |
A screening test for detecting sulfonylureas in plasma.
Topics: Aged; Aged, 80 and over; Chlorpropamide; Chromatography, High Pressure Liquid; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemia; Male; Middle Aged; Sulfonylurea Compounds; Tolbutamide | 1990 |
Rise of plasma t-PA fibrinolytic activity in a group of maturity onset diabetic patients shifted from a first generation (tolbutamide) to a second generation sulphonylurea (gliclazide).
Topics: Aged; Diabetes Mellitus, Type 2; Fibrinolysis; Gliclazide; Humans; Middle Aged; Sulfonylurea Compounds; Time Factors; Tissue Plasminogen Activator; Tolbutamide | 1989 |
Effect of different insulin secretagogues and blocking agents on islet cell Ca2+-ATPase activity.
Topics: Animals; Calcium-Transporting ATPases; Caproates; Cell Membrane; Gliclazide; Glucagon; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Keto Acids; Kinetics; Male; Rats; Somatostatin; Theophylline; Tolbutamide | 1988 |
Effects of sulfonylureas and clofibrate on insulin receptors in cultured human lymphocytes.
Topics: Cells, Cultured; Clofibrate; Gliclazide; Humans; Insulin; Lymphocytes; Receptor, Insulin; Sulfonylurea Compounds; Tolbutamide | 1985 |
Suppression by 2-ketoisocaproate of the insulinotropic action of hypoglycemic sulfonylureas.
Topics: Animals; Calcium; Gliclazide; Glucose; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Ionophores; Keto Acids; Oxidation-Reduction; Rats; Sulfonylurea Compounds; Tolbutamide | 1985 |
Sulfonylurea stimulates liver fructose-2,6-bisphosphate formation in proportion to its hypoglycemic action.
Topics: Acetohexamide; Animals; Buformin; Chlorpropamide; Fructosediphosphates; Gliclazide; Gluconeogenesis; Glyburide; Glycolysis; Hexosediphosphates; In Vitro Techniques; Liver; Male; Rats; Rats, Inbred Strains; Stimulation, Chemical; Sulfamethoxazole; Sulfonylurea Compounds; Tolbutamide | 1985 |
Opposite effects of hypoglycemic and hyperglycemic sulfonamides upon ionophore-mediated calcium transport.
Topics: Anti-Bacterial Agents; Blood Glucose; Calcimycin; Calcium; Diazoxide; Gliclazide; Hypoglycemic Agents; Lithium; Sodium; Sulfonamides; Tolbutamide | 1980 |
Homologous and hybrid calcium complexes of A23187 and hypoglycemic sulfonylureas: nuclear magnetic resonance and conformational analysis.
Topics: Anti-Bacterial Agents; Calcimycin; Calcium; Chemical Phenomena; Chemistry; Gliclazide; Glipizide; Magnetic Resonance Spectroscopy; Molecular Conformation; Sulfonylurea Compounds; Tolbutamide | 1982 |
Effects of gliclazide--a new antidiabetic agent--on blood platelet function in vitro and in vivo.
Topics: Adenosine Diphosphate; Animals; Collagen; Female; Gliclazide; Glipizide; Hemostasis; Humans; In Vitro Techniques; Lasers; Male; Microcirculation; Platelet Aggregation; Rabbits; Sulfonylurea Compounds; Tolbutamide | 1980 |
Potentiating effects of combined usage of three sulfonylurea drugs on the occurrence of alloxan diabetes in rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Combinations; Drug Synergism; Gliclazide; Glyburide; Hypoglycemic Agents; Rats; Rats, Wistar; Sulfonylurea Compounds; Tolbutamide | 1993 |
Gliclazide hydroxylation by rat liver microsomes.
Topics: Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Gliclazide; Glipizide; Glyburide; Hydroxylation; Hypoglycemic Agents; Kinetics; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Sprague-Dawley; Tolbutamide | 1995 |
Photohemolytic potency of oral antidiabetic drugs in vitro: effects of antioxidants and a nitrogen atmosphere.
Topics: Antioxidants; Ascorbic Acid; Carbutamide; Chlorpropamide; Dose-Response Relationship, Drug; Gliclazide; Glipizide; Glyburide; Hemolysis; Humans; Hypoglycemic Agents; Nitrogen; Radiation-Sensitizing Agents; Reactive Oxygen Species; Sulfonamides; Sulfonylurea Compounds; Superoxide Dismutase; Tolazamide; Tolbutamide; Ultraviolet Rays; Vitamin E | 1996 |
The ability of a new hypoglycaemic agent, A-4166, compared to sulphonylureas, to increase cytosolic Ca2+ in pancreatic beta-cells under metabolic inhibition.
Topics: Animals; Calcium; Cyclohexanes; Cytosol; Electron Transport; Enzyme Inhibitors; Gliclazide; Glucokinase; Glucose; Hypoglycemic Agents; Islets of Langerhans; Mitochondria; Nateglinide; Oxidative Phosphorylation; Phenylalanine; Rats; Rats, Wistar; Sulfonylurea Compounds; Tolbutamide | 1997 |
Inhibitory effect of sulfonylureas on protein phosphatase activity in rat pancreatic islets.
Topics: Animals; Cytosol; Gliclazide; Glyburide; Hypoglycemic Agents; Islets of Langerhans; Kinetics; Male; Okadaic Acid; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Sulfonylurea Compounds; Tolbutamide | 1997 |
Rates of hypoglycemia in users of sulfonylureas.
Topics: Adult; Aged; Chlorpropamide; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Incidence; Male; Middle Aged; Poisson Distribution; Risk; Risk Factors; Sulfonylurea Compounds; Surveys and Questionnaires; Time Factors; Tolbutamide | 1997 |
Effects of glycosylation of hypoglycaemic drug binding to serum albumin.
Topics: Acetohexamide; Binding Sites; Binding, Competitive; Gliclazide; Glyburide; Glycated Serum Albumin; Glycation End Products, Advanced; Glycosylation; Humans; Hypoglycemic Agents; Metformin; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Tolbutamide | 1997 |
The effects of gliclazide and other sulfonylureas on low-density lipoprotein oxidation in vitro.
Topics: Administration, Oral; Adult; Antioxidants; Ascorbic Acid; Coronary Artery Disease; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Lipoproteins, LDL; Male; Middle Aged; Oxidation-Reduction; Sulfonylurea Compounds; Tolbutamide | 1997 |
Characterization of low-affinity binding sites for glibenclamide on the Kir6.2 subunit of the beta-cell KATP channel.
Topics: Animals; ATP-Binding Cassette Transporters; Binding Sites; Blotting, Northern; Cell Line; Cell Membrane; COS Cells; Gliclazide; Glipizide; Glyburide; Islets of Langerhans; Kinetics; Organelles; Phentolamine; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Receptors, Drug; Recombinant Fusion Proteins; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide; Transfection | 1999 |
Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Cells, Cultured; Gene Expression; Gliclazide; Islets of Langerhans; Mice; Muscle, Smooth; Myocardium; Patch-Clamp Techniques; Potassium Channels; Rats; Sulfonylurea Compounds; Tolbutamide; Xenopus laevis | 1999 |
Comparison of capillary electrophoresis with HPLC for diagnosis of factitious hypoglycemia.
Topics: Adult; Chromatography, High Pressure Liquid; Diabetes Mellitus, Type 2; Drug Overdose; Electrophoresis, Capillary; Female; Gliclazide; Humans; Hypoglycemia; Hypoglycemic Agents; Middle Aged; Reproducibility of Results; Sulfonylurea Compounds; Tolbutamide | 2000 |
A novel simple method for the investigation of drug binding to the K(ATP) channel sulfonylurea receptor.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Gliclazide; Glyburide; Hypoglycemic Agents; Kinetics; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Receptors, Drug; Spodoptera; Sulfonylurea Receptors; Tolbutamide | 2002 |
Interaction of the cytosolic domains of the Kir6.2 subunit of the K(ATP) channel is modulated by sulfonylureas.
Topics: Animals; Cell Line; Cytosol; Fluorescence Resonance Energy Transfer; Gliclazide; Humans; Mice; Potassium Channels, Inwardly Rectifying; Protein Structure, Tertiary; Sulfonylurea Compounds; Tolbutamide | 2002 |
Taurine block of cloned ATP-sensitive K+ channels with different sulfonylurea receptor subunits expressed in Xenopus laevis oocytes.
Topics: Animals; ATP-Binding Cassette Transporters; Carbamates; Drug Interactions; Female; Gene Expression; Gliclazide; Glyburide; Hypoglycemic Agents; Membrane Proteins; Mice; Oocytes; Piperidines; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Subunits; Rats; Receptors, Drug; Sulfonylurea Receptors; Taurine; Tolbutamide; Xenopus laevis | 2004 |
Trace analysis of glyclazide in human plasma at microscale level by mass spectrometry.
Topics: Chromatography, Liquid; Gliclazide; Green Chemistry Technology; Humans; Hypoglycemic Agents; Molecular Structure; Reproducibility of Results; Sensitivity and Specificity; Solvents; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry; Tolbutamide | 2009 |
Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Blood Glucose; Calcium; Diabetes Mellitus, Experimental; Enzymes; Gene Expression Regulation, Enzymologic; Gliclazide; Hydrogen Peroxide; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Mice; Mice, Knockout; Oxidants; Oxidative Stress; Streptozocin; Tolbutamide | 2009 |
Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A.
Topics: ATP-Binding Cassette Transporters; Chlorpropamide; Cyclohexanes; Diabetes Mellitus, Type 2; Gene Expression Regulation; Gliclazide; Glyburide; Haplotypes; Homozygote; Humans; Isoindoles; Nateglinide; Patch-Clamp Techniques; Phenylalanine; Polymorphism, Single Nucleotide; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Structure-Activity Relationship; Sulfonylurea Compounds; Sulfonylurea Receptors; Tolbutamide | 2012 |
Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx.
Topics: Animals; Boron Compounds; Calcium; Calcium Channels, L-Type; Cell Line, Tumor; Cyclic AMP; Drug Synergism; Enzyme Activation; Gliclazide; GTP-Binding Protein alpha Subunits, Gi-Go; Guanine Nucleotide Exchange Factors; Hypoglycemic Agents; Indoles; Insulin; Insulin Secretion; Intracellular Space; KATP Channels; Maleimides; Membrane Potentials; Patch-Clamp Techniques; Rats; Tolbutamide; Type C Phospholipases | 2013 |
Mortality outcomes of different sulphonylurea drugs: the results of a 14-year cohort study of type 2 diabetic patients.
Topics: Adult; Aged; Cardiovascular Diseases; Cause of Death; Cohort Studies; Confounding Factors, Epidemiologic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Follow-Up Studies; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Insulin; Kaplan-Meier Estimate; Male; Metformin; Middle Aged; Neoplasms; Odds Ratio; Proportional Hazards Models; Research Design; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonylurea Compounds; Tolbutamide | 2013 |
Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study.
Topics: Aged; Carbamates; Cardiovascular Diseases; Denmark; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Morbidity; Myocardial Infarction; Piperidines; Registries; Retrospective Studies; Risk Factors; Stroke; Sulfonylurea Compounds; Tolbutamide | 2015 |
Sulfonylurea Blockade of KATP Channels Unmasks a Distinct Type of Glucose-Induced Ca2+ Decrease in Pancreatic β-Cells.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Calcium; Cells, Cultured; Clonidine; Female; Gliclazide; Glucose; Hypoglycemic Agents; Insulin-Secreting Cells; KATP Channels; Mice, Inbred C57BL; Receptors, Adrenergic, alpha-2; Sulfonylurea Compounds; Time Factors; Tolbutamide | 2017 |
Pharmacologic Differences of Sulfonylureas and the Risk of Adverse Cardiovascular and Hypoglycemic Events.
Topics: Aged; Aged, 80 and over; Body Mass Index; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gliclazide; Glipizide; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Incidence; Male; Middle Aged; Myocardial Infarction; Pancreas; Proportional Hazards Models; Risk Factors; Stroke; Sulfonylurea Compounds; Tolbutamide; United Kingdom | 2017 |
Energy depletion and not ROS formation is a crucial step of glucolipotoxicity (GLTx) in pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cells, Cultured; Energy Metabolism; Gliclazide; Glucose; Hypoglycemic Agents; Insulin; Insulin-Secreting Cells; KATP Channels; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Reactive Oxygen Species; Tolbutamide | 2018 |
Glucagonotropic and Glucagonostatic Effects of KATP Channel Closure and Potassium Depolarization.
Topics: Animals; Arginine; Calcium; Cell Membrane; Female; Gliclazide; Glucagon; Glucagon-Secreting Cells; Glucose; Hypoglycemic Agents; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Membrane Potentials; Mice; Potassium; Potassium Chloride; Tolbutamide | 2021 |
K
Topics: Animals; Calcium; Gliclazide; Glucagon; Glucagon-Secreting Cells; KATP Channels; Mice; Mice, Knockout; Mice, Transgenic; Potassium Channel Blockers; Somatostatin; Tolbutamide | 2021 |
Gap junctions and memory: an investigation using a single trial discrimination avoidance task for the neonate chick.
Topics: Animals; Astrocytes; Avoidance Learning; Central Nervous System Agents; Chickens; Dose-Response Relationship, Drug; Endothelin-1; Gap Junctions; Glycyrrhetinic Acid; Memory; Memory, Short-Term; Neuropsychological Tests; Random Allocation; Time Factors; Tolbutamide | 2010 |