gliclazide has been researched along with metformin in 122 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.82) | 18.7374 |
| 1990's | 11 (9.02) | 18.2507 |
| 2000's | 46 (37.70) | 29.6817 |
| 2010's | 54 (44.26) | 24.3611 |
| 2020's | 10 (8.20) | 2.80 |
| Authors | Studies |
|---|---|
| Ahmad, P; Kumar, A; Pathak, SR; Ray, S; Srivastava, AK; Tewari, P | 1 |
| Ahmad, P; Kumar, A; Maurya, RA; Singh, AB; Srivastava, AK | 1 |
| Ahmad, P; Kumar, A; Maurya, RA; Sharma, S; Singh, AB; Srivastava, AK; Tamrakar, AK | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Baick, SH; Cho, YW; Hong, SY; Kim, SJ; Kim, SK; Oh, DY; Yang, DH | 1 |
| Nandeuil, A; Noury, J | 1 |
| Frier, BM; Kay, JW; McAlpine, CH; McAlpine, LG; Storer, AM; Waclawski, ER | 1 |
| Chow, CC; Cockram, CS; Sorensen, JP; Tsang, LW | 1 |
| Ambrosi, F; Filipponi, P; Gregorio, F; Manfrini, S; Santucci, A | 1 |
| Guillausseau, PJ | 1 |
| Koyama, H; Mori, S; Nakajima, K; Sugioka, N; Uno, A | 1 |
| Broadhurst, RJ; Davis, TM; Hobbs, MS; Jamrozik, K; Parsons, RW | 1 |
| Arcangeli, A; Fiore, G; Galeone, F; Mannucci, E | 1 |
| Fülöp, T; Khalil, A; Maheux, P; Tessier, D | 1 |
| Shih, MF; Taberner, PV; Williams, CA | 1 |
| Ambrosi, F; Carle, F; Filipponi, P; Gregorio, F; Manfrini, S; Merante, D; Testa, R; Velussi, M | 1 |
| Belch, JJ; Jennings, PE | 1 |
| Gougeon, R; Jones, PJ; Marliss, EB; Morais, JA; Styhler, K | 1 |
| Ravi, J; Ravisankar, S; Suresh, B; Vasudevan, M | 1 |
| Brunelli, C; Cordera, R; Cordone, S; Olivotti, L; Rossettin, P; Schiavo, M; Spallarossa, P | 1 |
| Bonnefont-Rousselot, D | 1 |
| Anand, P; Arno, EA; Bhaskar, K; Ramachandran, S; Saravanan, M; Vinod, R | 1 |
| Banerjee, S; Singh, AK; Sinharoy, K | 1 |
| Antić, S; Bogicević, M; Milojković, M; Mitić-Zlatković, M; Stefanović, V; Stojiljković, S; Vlahović, P | 1 |
| Davis, KR; Dhindsa, P; Donnelly, R | 1 |
| Clark, PM; Gribble, FM; Hattersley, AT; Pearson, ER; Powell, RJ; Starkey, BJ | 1 |
| Furlong, NJ; Hardy, KJ; Hulme, SA; O'Brien, SV | 1 |
| Lawrence, JM; Reckless, JP; Reid, J; Stirling, C; Taylor, GJ | 1 |
| Campbell, IW | 1 |
| Abe, Y; Matsumoto, K; Miyake, S; Sera, Y; Tominaga, T; Yeki, Y | 1 |
| Stalder, Dde M | 1 |
| Belcher, G; Edwards, G; Goh, KL; Lambert, C; Valbuena, M | 1 |
| Hayaishi-Okano, R; Hori, M; Kaneto, H; Katakami, N; Kosugi, K; Matsuhisa, M; Ohtoshi, K; Yamasaki, Y | 1 |
| Edwards, G; Khan, M; Mariz, S; Urquhart, R; Xu, Y | 1 |
| Aburuz, S; McElnay, J; Millership, J | 1 |
| Corapçioğlu, D; Emral, R; Kamel, N; Köseoğlulari, O; Tonyukuk, V; Uysal, AR | 1 |
| Brunetti, P; Charbonnel, B; Hanefeld, M; Matthews, DR; Schernthaner, G; Tan, MH; Urquhart, R | 1 |
| Schumm-Draeger, PM | 1 |
| Belcher, G; Edwards, G; Lambert, C; Matthews, DR; Urquhart, R | 1 |
| Belcher, G; Schernthaner, G | 1 |
| Whitelaw, D | 1 |
| Bi, HC; Chen, X; Huang, M; Zhong, GP; Zhou, S | 1 |
| Betteridge, DJ; Vergès, B | 1 |
| Danhof, M; de Winter, W; DeJongh, J; Eckland, D; Moules, I; Ploeger, B; Post, T; Urquhart, R | 1 |
| Collober-Maugeais, C; Cressier, F; Pecher, E; Ristic, S | 1 |
| Collober-Maugeais, C; Cressier, F; Pecher, E; Ristic, S; Tang, P | 1 |
| Cholongitas, E; Pipili, C | 1 |
| Alagona, C; Chiavetta, A; Fedele, V; Leotta, C; Lorenti, I; Luca, S; Papa, G; Pezzino, V; Piro, S; Purrello, F; Rabuazzo, AM; Spadaro, L | 1 |
| Chen, R; Lopes, J | 1 |
| Balzi, D; Lamanna, C; Mannucci, E; Marchionni, N; Monami, M | 1 |
| Brazzale, AR; Mariz, S; Pacini, G; Roden, M | 1 |
| Amran, MS; Azam, AT; Hossain, MA; Mohiuddin, M | 1 |
| Bravis, V; Devendra, D; Gohel, B; Hassanein, M; Hui, E; Mehar, S; Salih, S | 1 |
| Kassem, SA; Raz, I | 1 |
| Cho, HY; Lee, YB; Lim, YC; Yoon, H | 1 |
| Agra, R; Albuquerque, JL; Arahata, C; Arruda, MJ; Canadas, V; Gusmão, A; Montenegro, L; Pontes, L; Silva, LM; Vilar, CF; Vilar, L | 1 |
| Filozof, C; Gautier, JF | 1 |
| Elsukova, OS; Onuchin, SG; Onuchina, EL; Solov'ev, OV | 2 |
| Chen, LL; Feng, Y; Li, HQ; Liao, YF; Yu, F; Zeng, TS | 1 |
| da Cunha, FX; Louro, TM; Matafome, PN; Nunes, EC; Seiça, RM | 1 |
| Boyle, JG; Cleland, SJ; Connell, JM; Jones, GC; Logan, PJ; Salt, IP; Sattar, N; Small, M | 1 |
| Chalmers, J; De Bruin, ML; Grobbee, DE; Kengne, AP; Knol, MJ; Leufkens, HG; Patel, A; Stefansdottir, G; Woodward, M; Zoungas, S | 1 |
| Andrews, C; Barnett, A; Geransar, P; Hanif, W; Hassanein, M; Kamal, A; Lister, N; Malik, W | 1 |
| Al-Azzam, SI; Almahasneh, FA; Alomari, M; Altawalbeh, S; Khader, YS; Muflih, SM | 1 |
| Chowdhury, TA; Green, AN; Gupta, PS | 1 |
| Jermendy, G | 1 |
| Babjakova, E; Fabianova, M; Javorsky, M; Klimcakova, L; Kozarova, M; Salagovic, J; Schroner, Z; Tkac, I; Tkacova, R; Zidzik, J | 1 |
| Lim, PC; Lim, SL; Oiyammaal, C | 1 |
| Binz, TM; Neels, H; Schneider, S; Villani, N | 1 |
| Bo, S; Castiglione, A; Cavallo-Perin, P; Ciccone, G; Durazzo, M; Gentile, L; Ghigo, E | 1 |
| Geng, XN; Liang, HG; Pu, R; Shi, LW; Yu, F | 1 |
| Agrawal, N; Bhandari, S; Chandurkar, N; Deshpande, A; Devaramani, S; Gupta, OP; Kakrani, A; Kothari, K; Mahesh, M; Pareek, A; Saboo, B; Shah, A; Sharma, S; Thomas, N; Thulasidharan, NK; Vijaykumar, NB; Viswanathan, V | 1 |
| Civan, N; Deger, O; Erem, C; Ersoz, HO; Nuhoglu, I; Ozbas, HM | 1 |
| Khalangot, M; Kovtun, V | 1 |
| Buranphalin, S; Doomkaew, A; Prapatpong, P; Suntornsuk, L; Vander Heyden, Y | 1 |
| Andersson, C; Fosbøl, EL; Gislason, G; Køber, L; Mogensen, UM; Scheller, NM; Schramm, TK; Torp-Pedersen, C; Vaag, A | 1 |
| Cartner, M; Graham, RE; Winearls, J | 1 |
| Chan, SP; Colagiuri, S | 1 |
| Abd-Allah, GM; Hassan, MH | 1 |
| Remon, JP; Vervaet, C; Voorspoels, J; Vynckier, AK | 1 |
| Jing, W; Shunyou, D; Xiaochun, H; Xiaoyan, C; Yingyu, F; Yuyu, T | 1 |
| García Díaz, E; Godoy, T; Guagnozzi, D; Gutiérrez, V; Larrañaga, Y; Maza, C; Mendoza, C; Perdomo, D; Taleb, G | 1 |
| Anderson, AJ; Andrew, R; Homer, NZ; Jones, GC; Livingstone, DE; Smith, K; Stimson, RH; Walker, BR | 1 |
| Ersoy-Evans, S; Gököz, O; Gönül, M; Keseroglu, HO; Taş-Aygar, G | 1 |
| Alam, F; Gan, SH; Islam, MA; Kamal, MA | 1 |
| Bilo, H; Bouma, A; Groenier, KH; Kleefstra, N; Landman, GW; van Dijk, P; van Hateren, KJ | 1 |
| Chopra, V; Jain, S; Jayaprakashsai, J; Mohan, V; Sanyal, D | 1 |
| Cao, X; Feng, X; Hu, Y; Jiang, L; Li, Q; Liu, C; Luo, Y; Ma, J; Wang, Y; Yan, R; Yang, F; Yuan, L; Zhao, E; Zhu, Y | 1 |
| Bi, Y; Engel, SS; Ji, L; Ji, Q; Jia, W; Lu, J; Mao, A; Mu, Y; Ran, X; Weng, J; Xu, W; Yang, W; Yao, B; Zeng, L; Zhao, B; Zhao, J; Zhou, Z; Zhu, D | 1 |
| Bilz, S; Brändle, M; Fournier, JY; Quarella, M; Walser, D | 1 |
| Bi, Y; Chen, W; Feng, W; Gao, C; Li, P; Shen, S; Wu, M; Yin, T; Zhu, D | 1 |
| Lee, TC; McDonald, EG; Raslan, IA | 1 |
| Das, AK; Kalra, S | 1 |
| Fatima, Z; Kaur, CD; Srivastava, D | 1 |
| Faria-Neto, JR; Lacerda, CS; Marino, EC; Pechmann, LM; Polesel, MG; Vianna, AGD | 1 |
| Garcia de Lucas, MD; Gómez Huelgas, R; Olalla Sierra, J; Pérez Belmonte, LM; Suárez Tembra, M | 1 |
| Bi, Y; Feng, WH; Gao, CX; Gao, LJ; Li, P; Shen, SM; Yang, DH; Yin, TT; Zhu, DL | 1 |
| Cordiner, RLM; Pearson, ER | 1 |
| Al-Salami, H; Dass, CR; Gedawy, A | 1 |
| Malarvizhi, R; Mani, S; Nithya, P; Sekar, V; Vasanthi, HR | 1 |
| Bhutani, R; Bodla, RB; Kant, R; Kapoor, G | 1 |
| Atkinson, A; Havard, A; Kelty, E; Preen, DB; Tran, DD | 1 |
| Dǎnciulescu-Miulescu, R; Gagniuc, E; Grǎdinaru, D; Guţu, C; Ionescu-Tȋrgovişte, C; Marginǎ, D; Olaru, OT; Şeremet, O; Ungurianu, A | 1 |
| Bozovic, A; Danser, AHJ; Emanuel, AL; Geurts, F; Hoorn, EJ; Joles, JA; Kramer, MHH; Larsen, EL; Muskiet, MHA; Nieuwdorp, M; Poulsen, HE; Smits, MM; Tonneijck, L; Touw, DJ; van Baar, MJB; van Bommel, EJM; van Raalte, DH | 1 |
| Barathidasan, R; Malarvizhi, R; Mani, S; Sekar, V; Vasanthi, HR | 1 |
| Cortese, V; Davies, MJ; Jacquot, E; Khunti, K; Seidu, S; Tyrer, F; Zaccardi, F | 1 |
| Chen, J; Chen, Y; Fang, W; Gao, S; Guo, Y; Hu, R; Liu, S; Lu, W; Shen, Q; Wang, B; Yu, L | 1 |
| Chiriac, FL; Iancu, VI; Radu, GL; Scutariu, RE | 1 |
| Fu, BY; Wang, XJ | 1 |
| Hussain, F; Khan, M; Parvez, M | 1 |
| Gayakvad, B; Kothari, C; Patel, C; Patel, R; Solanki, R; Wadhwana, P | 1 |
| Bakulin, DA; Ivanova, OV; Kolosov, YA; Krysanov, IS; Kudrin, RA; Kurkin, DV; Makarova, EV; Robertus, AI | 1 |
14 review(s) available for gliclazide and metformin
| Article | Year |
|---|---|
[Antioxidant and anti-AGE therapeutics: evaluation and perspectives].
Topics: Antioxidants; Chromans; Diabetes Mellitus; Gliclazide; Glycation End Products, Advanced; Guanidines; Humans; Hypoglycemic Agents; Metformin; Oxidative Stress; Receptor for Advanced Glycation End Products; Receptors, Immunologic; Thiazoles; Thiazolidinediones; Troglitazone | 2001 |
Oral hypoglycaemic agent failure.
Topics: Administration, Oral; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Metformin; Treatment Failure | 2002 |
Long-term glycaemic control with pioglitazone in patients with type 2 diabetes.
Topics: Diabetes Mellitus, Type 2; Drug Therapy, Combination; Gliclazide; Humans; Hypoglycemic Agents; Metformin; Pioglitazone; Randomized Controlled Trials as Topic; Thiazolidinediones; Treatment Outcome | 2004 |
Cardiovascular effects of treatment of type 2 diabetes with pioglitazone, metformin and gliclazide.
Topics: Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Double-Blind Method; Female; Gliclazide; Heart Failure; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Myocardial Infarction; Pioglitazone; Randomized Controlled Trials as Topic; Stroke; Thiazolidinediones | 2004 |
[Controversial therapeutic strategies in the treatment of type 2 diabetes mellitus].
Topics: Cardiovascular Diseases; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Follow-Up Studies; Gliclazide; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Pioglitazone; Risk Factors; Rosiglitazone; Thiazolidinediones; Time Factors | 2005 |
Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity or mortality? No.
Topics: Administration, Oral; Cardiovascular Diseases; Diabetic Angiopathies; Disease Progression; Enzyme Inhibitors; Gliclazide; Glycoside Hydrolase Inhibitors; Humans; Hypoglycemic Agents; Metformin; Morbidity; Predictive Value of Tests; Sulfonylurea Compounds; Thiazolidinediones | 2009 |
[Hypoglycemia].
Topics: Algorithms; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Gliclazide; Humans; Hypoglycemia; Hypoglycemic Agents; Insulin Glargine; Insulin, Long-Acting; Male; Metformin; Middle Aged; Risk Factors | 2011 |
[Incretin-based therapy for treating patients with type 2 diabetes].
Topics: Adamantane; Body Mass Index; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Approval; Drug Therapy, Combination; Exenatide; Gliclazide; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glycated Hemoglobin; Humans; Hungary; Hypoglycemic Agents; Incretins; Linagliptin; Liraglutide; Metformin; Nitriles; Peptides; Pioglitazone; Purines; Pyrazines; Pyrrolidines; Quinazolines; Receptors, Glucagon; Sitagliptin Phosphate; Sulfonylurea Compounds; Thiazolidinediones; Triazoles; Venoms; Vildagliptin | 2011 |
Liuwei dihuang pills enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials.
Topics: Blood Glucose; Case-Control Studies; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal; Fasting; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Publication Bias; Randomized Controlled Trials as Topic; Treatment Outcome; Western World | 2013 |
Systematic review and meta-analysis of the efficacy and hypoglycemic safety of gliclazide versus other insulinotropic agents.
Topics: Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Gliclazide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; Middle Aged; Randomized Controlled Trials as Topic; Sulfonylurea Compounds; Treatment Outcome; Young Adult | 2015 |
Updates on Managing Type 2 Diabetes Mellitus with Natural Products: Towards Antidiabetic Drug Development.
Topics: Biological Products; Diabetes Mellitus, Type 2; Drug Discovery; Gliclazide; Glucose Transporter Type 4; Humans; Hypoglycemic Agents; Metformin; Oxidative Stress; Sulfonylurea Compounds | 2018 |
Gliclazide-Induced Insulin Autoimmune Syndrome: A Rare Case Report and Review on Literature.
Topics: Acarbose; Aged; Autoimmune Diseases; Diabetes Mellitus, Type 2; Drug Substitution; Gliclazide; Humans; Insulin Antibodies; Male; Metformin; Syndrome | 2016 |
Multicomponent Pharmaceutical Cocrystals: A Novel Approach for Combination Therapy.
Topics: Asthma; Chemistry, Pharmaceutical; Crystallization; Diabetes Mellitus; Drug Therapy, Combination; Flufenamic Acid; Gliclazide; Humans; Metformin; Pharmaceutical Preparations; Theophylline | 2018 |
Reflections on the sulphonylurea story: A drug class at risk of extinction or a drug class worth reviving?
Topics: Diabetes Mellitus; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Dose-Response Relationship, Drug; Gliclazide; Glipizide; Glucagon-Like Peptide-1 Receptor; Glyburide; History, 20th Century; History, 21st Century; Humans; Hypoglycemic Agents; Insulin Secretion; Insulin-Secreting Cells; Metformin; Sodium-Glucose Transporter 2 Inhibitors; Sulfonylurea Compounds; Treatment Failure | 2019 |
40 trial(s) available for gliclazide and metformin
| Article | Year |
|---|---|
Comparative three-month study of the efficacies of metformin and gliclazide in the treatment of NIDD.
Topics: Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Fasting; Female; Gliclazide; Humans; Insulin; Male; Metformin; Middle Aged; Triglycerides | 1991 |
Comparison of insulin with or without continuation of oral hypoglycemic agents in the treatment of secondary failure in NIDDM patients.
Topics: Analysis of Variance; Biomarkers; Blood Glucose; Body Mass Index; C-Peptide; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Fructosamine; Gliclazide; Glipizide; Glyburide; Glycated Hemoglobin; Hexosamines; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Treatment Failure; Triglycerides | 1995 |
Meformin, plasma glucose and free fatty acids in type II diabetic out-patients: results of a clinical study.
Topics: Blood Glucose; Body Constitution; Body Mass Index; C-Peptide; Cholesterol; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Fatty Acids, Nonesterified; Female; Gliclazide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipoprotein(a); Male; Metformin; Middle Aged; Regression Analysis; Sex Characteristics | 1997 |
[Gliclazide and metformin combination in patients with type 2 diabetes. Preliminary data].
Topics: Diabetes Mellitus, Type 2; Drug Combinations; Female; Gliclazide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Prospective Studies | 1998 |
Effects of gliclazide versus metformin on the clinical profile and lipid peroxidation markers in type 2 diabetes.
Topics: Aged; Biomarkers; Diabetes Mellitus, Type 2; Female; Gliclazide; Humans; Hypoglycemic Agents; Lipid Peroxides; Lipoproteins, HDL; Lipoproteins, LDL; Male; Metformin; Middle Aged; Treatment Outcome; Vitamin E | 1999 |
Poorly controlled elderly Type 2 diabetic patients: the effects of increasing sulphonylurea dosages or adding metformin.
Topics: Aged; Aging; Antithrombin III; Blood Glucose; Blood Platelets; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Fibrinolysis; Gliclazide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Thrombin | 1999 |
Free radical scavenging activity of sulfonylureas: a clinical assessment of the effect of gliclazide.
Topics: Adult; Aged; Blood Platelets; Collagen; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Free Radical Scavengers; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Oxidation-Reduction; Sulfonylurea Compounds | 2000 |
Sulfonylurea treatment of type 2 diabetic patients does not reduce the vasodilator response to ischemia.
Topics: Aged; Aged, 80 and over; Blood Pressure; Brachial Artery; Diabetes Mellitus, Type 2; Diet, Diabetic; Female; Forearm; Gliclazide; Glyburide; Humans; Hyperlipidemias; Hypertension; Hypoglycemic Agents; Ischemia; Male; Metformin; Middle Aged; Reference Values; Regional Blood Flow; Sulfonylurea Compounds; Ultrasonography | 2001 |
Comparison of the micro- and macro-vascular effects of glimepiride and gliclazide in metformin-treated patients with Type 2 diabetes: a double-blind, crossover study.
Topics: Aged; Cross-Over Studies; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Gliclazide; Humans; Hypoglycemic Agents; Metformin; Microcirculation; Middle Aged; Sulfonylurea Compounds; Vasodilation | 2003 |
Genetic cause of hyperglycaemia and response to treatment in diabetes.
Topics: Adult; Aged; ATP-Binding Cassette Transporters; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; DNA-Binding Proteins; Fasting; Female; Gliclazide; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nuclear Proteins; Potassium Channels; Potassium Channels, Inwardly Rectifying; Receptors, Drug; Sulfonylurea Receptors; Transcription Factors | 2003 |
Comparison of repaglinide vs. gliclazide in combination with bedtime NPH insulin in patients with Type 2 diabetes inadequately controlled with oral hypoglycaemic agents.
Topics: Administration, Oral; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Hemoglobin A; Humans; Hypoglycemic Agents; Insulin, Isophane; Male; Metformin; Middle Aged; Patient Satisfaction; Piperidines; Surveys and Questionnaires; Weight Gain | 2003 |
Favorable effects of pioglitazone and metformin compared with gliclazide on lipoprotein subfractions in overweight patients with early type 2 diabetes.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus; Diabetes Mellitus, Type 2; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Male; Metformin; Middle Aged; Obesity; Pioglitazone; Thiazolidinediones; Triglycerides | 2004 |
Metformin or gliclazide, rather than glibenclamide, attenuate progression of carotid intima-media thickness in subjects with type 2 diabetes.
Topics: Carotid Arteries; Carotid Artery Diseases; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Follow-Up Studies; Gliclazide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Multivariate Analysis; Tunica Intima; Tunica Media | 2004 |
Effects of pioglitazone on the components of diabetic dyslipidaemia: results of double-blind, multicentre, randomised studies.
Topics: Adult; Aged; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Fatty Acids, Nonesterified; Female; Gliclazide; Humans; Hyperlipidemias; Hypoglycemic Agents; Insulin Resistance; Male; Metformin; Middle Aged; Pioglitazone; Prospective Studies; Thiazolidinediones; Treatment Outcome; Triglycerides | 2004 |
Long-term efficacy and tolerability of add-on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetes.
Topics: Adult; Aged; C-Peptide; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Pioglitazone; Reproducibility of Results; Safety; Thiazolidinediones; Treatment Failure; Treatment Outcome | 2005 |
Safety and tolerability of pioglitazone, metformin, and gliclazide in the treatment of type 2 diabetes.
Topics: Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Double-Blind Method; Female; gamma-Glutamyltransferase; Gliclazide; Glycated Hemoglobin; Hematocrit; Humans; Hypoglycemic Agents; Leukocyte Count; Male; Metformin; Middle Aged; Pioglitazone; Platelet Count; Thiazolidinediones | 2005 |
Changes in liver tests during 1-year treatment of patients with Type 2 diabetes with pioglitazone, metformin or gliclazide.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Liver Diseases; Liver Extracts; Male; Metformin; Middle Aged; Pioglitazone; Thiazolidinediones | 2005 |
Long-term effects on lipids and lipoproteins of pioglitazone versus gliclazide addition to metformin and pioglitazone versus metformin addition to sulphonylurea in the treatment of type 2 diabetes.
Topics: Adult; Aged; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Dyslipidemias; Gliclazide; Humans; Hypoglycemic Agents; Lipids; Lipoproteins; Metformin; Middle Aged; Pioglitazone; Risk Factors; Sulfonylurea Compounds; Thiazolidinediones; Time Factors; Triglycerides | 2005 |
Comparison of nateglinide and gliclazide in combination with metformin, for treatment of patients with Type 2 diabetes mellitus inadequately controlled on maximum doses of metformin alone.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Nateglinide; Phenylalanine; Postprandial Period; Treatment Outcome | 2006 |
Nateglinide or gliclazide in combination with metformin for treatment of patients with type 2 diabetes mellitus inadequately controlled on maximum doses of metformin alone: 1-year trial results.
Topics: Aged; Cyclohexanes; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nateglinide; Phenylalanine; Safety; Time Factors | 2007 |
Therapeutic options for elderly diabetic subjects: open label, randomized clinical trial of insulin glargine added to oral antidiabetic drugs versus increased dosage of oral antidiabetic drugs.
Topics: Administration, Oral; Aged; Blood Glucose; Body Mass Index; Carbamates; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Glargine; Insulin, Long-Acting; Male; Metformin; Pioglitazone; Piperidines; Research Design; Rosiglitazone; Thiazolidinediones | 2008 |
Free fatty acid kinetics during long-term treatment with pioglitazone added to sulfonylurea or metformin in Type 2 diabetes.
Topics: Adult; Aged; Analysis of Variance; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Fatty Acids, Nonesterified; Female; Gliclazide; Glucose Tolerance Test; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pioglitazone; Sulfonylurea Compounds; Thiazolidinediones | 2009 |
Pharmacokinetics and bioequivalence evaluation of gliclazide/metformin combination tablet and equivalent doses of gliclazide and metformin in healthy Korean subjects.
Topics: Adult; Cross-Over Studies; Drug Combinations; Gliclazide; Humans; Hypoglycemic Agents; Korea; Male; Metformin; Tablets; Therapeutic Equivalency | 2009 |
A comparison of efficacy and safety of vildagliptin and gliclazide in combination with metformin in patients with Type 2 diabetes inadequately controlled with metformin alone: a 52-week, randomized study.
Topics: Adamantane; Adolescent; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nitriles; Pyrrolidines; Vildagliptin; Young Adult | 2010 |
[Capabilities of hypoglycemic therapy in women with decompensated type 2 diabetes mellitus].
Topics: Blood Glucose; Carbohydrate Metabolism; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Lipid Metabolism; Metformin; Middle Aged; Prospective Studies; Quality of Life; Treatment Outcome | 2010 |
Effects of metformin plus gliclazide compared with metformin alone on circulating endothelial progenitor cell in type 2 diabetic patients.
Topics: Adult; Biomarkers; Cell Movement; Cells, Cultured; Cholesterol, LDL; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Endothelial Cells; Female; Flow Cytometry; Gliclazide; Hematopoietic Stem Cells; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Oxidative Stress | 2010 |
AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study.
Topics: Aged; AMP-Activated Protein Kinases; Cross-Over Studies; Diabetes Mellitus, Type 2; Gliclazide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged | 2011 |
Intensive glucose control and risk of cancer in patients with type 2 diabetes.
Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Female; Gliclazide; Humans; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Neoplasms | 2011 |
KCNJ11 gene E23K variant and therapeutic response to sulfonylureas.
Topics: Adult; Aged; Cohort Studies; Diabetes Mellitus, Type 2; Drug Resistance; Drug Therapy, Combination; Female; Genetic Variation; Genotype; Gliclazide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pharmacogenetics; Polymorphism, Genetic; Potassium Channels, Inwardly Rectifying; Sulfonylurea Compounds | 2012 |
Efficacy and safety of hydroxychloroquine in the treatment of type 2 diabetes mellitus: a double blind, randomized comparison with pioglitazone.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Diabetes Mellitus, Type 2; Double-Blind Method; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hydroxychloroquine; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pioglitazone; Sulfonylurea Compounds; Thiazolidinediones; Treatment Outcome; Young Adult | 2014 |
Comparison of effects of gliclazide, metformin and pioglitazone monotherapies on glycemic control and cardiovascular risk factors in patients with newly diagnosed uncontrolled type 2 diabetes mellitus.
Topics: Adult; Aged; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Gliclazide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pioglitazone; Risk Factors; Thiazolidinediones | 2014 |
Effects of metformin plus gliclazide versus metformin plus glimepiride on cardiovascular risk factors in patients with type 2 diabetes mellitus.
Topics: Adult; Aged; Blood Glucose; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Folic Acid; Gliclazide; Glycated Hemoglobin; Homocysteine; Humans; Hypoglycemic Agents; Lipids; Male; Metformin; Middle Aged; Risk Factors; Sulfonylurea Compounds | 2015 |
Effects of vildagliptin versus saxagliptin on daily acute glucose fluctuations in Chinese patients with T2DM inadequately controlled with a combination of metformin and sulfonylurea.
Topics: Adamantane; Aged; Asian People; Blood Glucose; China; Diabetes Mellitus, Type 2; Dipeptides; Dipeptidyl-Peptidase IV Inhibitors; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Nitriles; Prospective Studies; Pyrrolidines; Sulfonylurea Compounds; Vildagliptin | 2016 |
Metformin Increases Cortisol Regeneration by 11βHSD1 in Obese Men With and Without Type 2 Diabetes Mellitus.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Comorbidity; Cross-Over Studies; Diabetes Mellitus, Type 2; Double-Blind Method; Gliclazide; Humans; Hydrocortisone; Hypoglycemic Agents; Male; Metformin; Obesity; Treatment Outcome | 2016 |
Hypoglycemia in Frail Elderly Patients With Type 2 Diabetes Mellitus Treated With Sulfonylurea.
Topics: Aged; Aged, 80 and over; Blood Glucose Self-Monitoring; Diabetes Mellitus, Type 2; Female; Frail Elderly; Gliclazide; Humans; Hypoglycemia; Hypoglycemic Agents; Male; Metformin; Sulfonylurea Compounds | 2017 |
Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy (STRATEGY): a multicenter, randomized, controlled, non-inferiority clinical trial.
Topics: Acarbose; Adult; Blood Glucose; Carbamates; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Piperidines; Sitagliptin Phosphate; Sulfonylurea Compounds; Treatment Outcome | 2017 |
Randomized trial comparing the effects of gliclazide, liraglutide, and metformin on diabetes with non-alcoholic fatty liver disease.
Topics: Adipose Tissue; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Liraglutide; Liver Function Tests; Male; Metformin; Middle Aged; Non-alcoholic Fatty Liver Disease | 2017 |
A randomized controlled trial to compare the effects of sulphonylurea gliclazide MR (modified release) and the DPP-4 inhibitor vildagliptin on glycemic variability and control measured by continuous glucose monitoring (CGM) in Brazilian women with type 2
Topics: Adamantane; Adult; Aged; Blood Glucose; Blood Glucose Self-Monitoring; Brazil; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Nitriles; Pyrrolidines; Sulfonylurea Compounds; Treatment Outcome; Vildagliptin | 2018 |
Effects of liraglutide, metformin and gliclazide on body composition in patients with both type 2 diabetes and non-alcoholic fatty liver disease: A randomized trial.
Topics: Adolescent; Adult; Aged; Biomarkers; Blood Glucose; Body Composition; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Liraglutide; Liver Function Tests; Male; Metformin; Middle Aged; Non-alcoholic Fatty Liver Disease; Prognosis; Prospective Studies; Young Adult | 2019 |
The renal hemodynamic effects of the SGLT2 inhibitor dapagliflozin are caused by post-glomerular vasodilatation rather than pre-glomerular vasoconstriction in metformin-treated patients with type 2 diabetes in the randomized, double-blind RED trial.
Topics: Aged; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Double-Blind Method; Female; Gliclazide; Glomerular Filtration Rate; Glucosides; Glycated Hemoglobin; Humans; Kidney; Male; Metformin; Middle Aged; Sodium-Glucose Transporter 2 Inhibitors; Treatment Outcome; Vasoconstriction; Vasodilation | 2020 |
68 other study(ies) available for gliclazide and metformin
| Article | Year |
|---|---|
Novel substituted naphthalen-1-yl-methanone derivatives as anti-hyperglycemic agents.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Naphthalenes; Rats; Rats, Sprague-Dawley; Streptozocin | 2006 |
Novel 2-aryl-naphtho[1,2-d]oxazole derivatives as potential PTP-1B inhibitors showing antihyperglycemic activities.
Topics: Animals; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hypoglycemic Agents; Lipids; Mice; Oxazoles; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Structure-Activity Relationship; Triglycerides | 2009 |
Design and synthesis of 3,5-diarylisoxazole derivatives as novel class of anti-hyperglycemic and lipid lowering agents.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Hypoglycemic Agents; Hypolipidemic Agents; Isoxazoles; Male; Mice; Mice, Inbred C57BL; PPAR gamma; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Rats; Rats, Sprague-Dawley; Rats, Wistar; Streptozocin; Sucrose; Triglycerides | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
Topics: | 2008 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Plasma t-PA and PAl-1 antigen concentrations in non-insulin dependent diabetic patients: effects of treatment modality on fibrinolysis.
Topics: Antigens; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Female; Fibrinolysis; Gliclazide; Humans; Insulin; Male; Metformin; Middle Aged; Plasminogen Activator Inhibitor 1; Tissue Plasminogen Activator | 1992 |
A comparison of treatment with metformin and gliclazide in patients with non-insulin-dependent diabetes.
Topics: Adult; Aged; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Female; Gliclazide; Humans; Insulin; Lactates; Male; Metformin; Middle Aged; Sulfonylurea Compounds | 1988 |
Monitoring of metabolic control in patients with non-insulin-dependent diabetes mellitus on oral hypoglycaemic agents: value of evening blood glucose determination.
Topics: Administration, Oral; Aged; Blood Glucose; Circadian Rhythm; Cohort Studies; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Postprandial Period; Prospective Studies | 1997 |
Effects of glycosylation of hypoglycaemic drug binding to serum albumin.
Topics: Acetohexamide; Binding Sites; Binding, Competitive; Gliclazide; Glyburide; Glycated Serum Albumin; Glycation End Products, Advanced; Glycosylation; Humans; Hypoglycemic Agents; Metformin; Serum Albumin; Spectrometry, Fluorescence; Structure-Activity Relationship; Tolbutamide | 1997 |
Arrhythmias and mortality after myocardial infarction in diabetic patients. Relationship to diabetes treatment.
Topics: Adult; Arrhythmias, Cardiac; Diabetes Complications; Diabetes Mellitus; Digitalis Glycosides; Diuretics; Female; Gliclazide; Heart Block; Humans; Hypertension; Hypoglycemic Agents; Insulin; Male; Metformin; Middle Aged; Multivariate Analysis; Myocardial Infarction; Odds Ratio; Pulmonary Edema; Regression Analysis; Retrospective Studies; Smoking; Survival Rate; Time Factors | 1998 |
A simple acute in vivo comparative test for sensitivity to insulin in the mouse.
Topics: Animals; Blood Glucose; Dose-Response Relationship, Drug; Gliclazide; Hypoglycemic Agents; Insulin; Male; Metformin; Mice; Mice, Inbred CBA; Reagent Strips | 1999 |
Effects of oral hypoglycemic agents and diet on protein metabolism in type 2 diabetes.
Topics: Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; Diet, Diabetic; Drug Therapy, Combination; Fatty Acids, Nonesterified; Female; Gliclazide; Glycosuria; Humans; Hypoglycemic Agents; Kinetics; Male; Metformin; Middle Aged; Obesity; Proteins; Urea; Weight Loss | 2000 |
ION-pair liquid chromatography technique for the estimation of metformin in its multicomponent dosage forms.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Gliclazide; Glipizide; Hypoglycemic Agents; Metformin; Quality Control; Reference Standards; Reproducibility of Results | 2001 |
Eudragit NE30D based metformin/gliclazide extended release tablets: formulation, characterisation and in vitro release studies.
Topics: Chemistry, Pharmaceutical; Delayed-Action Preparations; Gliclazide; Metformin; Polymethacrylic Acids; Tablets | 2002 |
Urinary PC-1 and N-acetyl-beta-D-glucosaminidase activity in patients with type 2 diabetes treated with metformin, gliclazide or glibenclamide.
Topics: Acetylglucosaminidase; Administration, Oral; Adult; Aged; Creatinine; Diabetes Mellitus, Type 2; Female; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Obesity; Phosphoric Diester Hydrolases; Pyrophosphatases | 2003 |
Metformin attenuates progression of carotid arterial wall thickness in patients with type 2 diabetes.
Topics: Arteriosclerosis; Carotid Arteries; Carotid Artery Diseases; Chronic Disease; Diabetes Mellitus, Type 2; Diet Therapy; Drug Administration Schedule; Female; Gliclazide; Glyburide; Glycated Hemoglobin; Humans; Japan; Male; Metformin; Middle Aged; Prospective Studies; Sulfonylurea Compounds; Time Factors; Tunica Intima; Tunica Media | 2004 |
[Long-term HbA1c stable. Insulin sensitizer keeps diabetes in check].
Topics: Diabetes Mellitus, Type 2; Drug Therapy, Combination; Follow-Up Studies; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Pioglitazone; Randomized Controlled Trials as Topic; Thiazolidinediones; Treatment Outcome | 2004 |
[Therapy objectives and daily practice--to which extent are blood sugar target values accessible in daily practice?].
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Cost-Benefit Analysis; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Patient Compliance; Quality of Life; Weight Loss | 2004 |
[2-year data of large clinical comparative studies. Type 2 diabetes: lasting metabolic control with pioglitazone].
Topics: Animals; Clinical Trials as Topic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Gliclazide; Humans; Hypoglycemic Agents; Insulin Resistance; Metformin; Mice; Pioglitazone; Thiazolidinediones; Time Factors | 2004 |
The development and validation of liquid chromatography method for the simultaneous determination of metformin and glipizide, gliclazide, glibenclamide or glimperide in plasma.
Topics: Chromatography, High Pressure Liquid; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Metformin; Reference Standards; Sensitivity and Specificity | 2005 |
The effect of short-term glycemic regulation with gliclazide and metformin on postprandial lipemia.
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Fasting; Gliclazide; Homeostasis; Humans; Hypoglycemic Agents; Leptin; Metformin; Postprandial Period | 2005 |
Management of diabetes during Ramadan.
Topics: Adult; Diabetes Mellitus, Type 2; Drug Administration Schedule; Fasting; Female; Gliclazide; Humans; Hypoglycemic Agents; Islam; Male; Metformin; Rosiglitazone; Thiazolidinediones | 2005 |
Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers.
Topics: Calibration; Chromatography, Liquid; Gliclazide; Health; Humans; Metformin; Molecular Structure; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Therapeutic Equivalency | 2005 |
A mechanism-based disease progression model for comparison of long-term effects of pioglitazone, metformin and gliclazide on disease processes underlying Type 2 Diabetes Mellitus.
Topics: Adult; Aged; Algorithms; Blood Glucose; Clinical Trials, Phase III as Topic; Diabetes Mellitus, Type 2; Disease Progression; Double-Blind Method; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Insulin; Insulin Resistance; Insulin-Secreting Cells; Male; Metformin; Middle Aged; Models, Biological; Multicenter Studies as Topic; Pioglitazone; Randomized Controlled Trials as Topic; Thiazolidinediones; Treatment Outcome | 2006 |
Erythromelalgia in a diabetic patient managed with gabapentin.
Topics: Aged, 80 and over; Amines; Analgesics; Cyclohexanecarboxylic Acids; Diabetes Complications; Diabetes Mellitus; Drug Therapy, Combination; Erythromelalgia; Female; Gabapentin; gamma-Aminobutyric Acid; Gliclazide; Humans; Hypoglycemic Agents; Metformin | 2008 |
Hyperglycaemia secondary to mirtazapine therapy in a 37-year-old man.
Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder, Major; Drug Therapy, Combination; Gliclazide; Humans; Hyperglycemia; Hypoglycemic Agents; Male; Metformin; Mianserin; Mirtazapine | 2008 |
Sulphonylureas and cancer: a case-control study.
Topics: Aged; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Follow-Up Studies; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Neoplasms; Risk Factors; Sulfonylurea Compounds | 2009 |
In vive effects of gliclazide and metformin on the plasma concentration of caffeine in healthy rats.
Topics: Animals; Caffeine; Gliclazide; Hypoglycemic Agents; Metformin; Rats | 2009 |
Vildagliptin therapy and hypoglycaemia in Muslim type 2 diabetes patients during Ramadan.
Topics: Adamantane; Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Fasting; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemia; Hypoglycemic Agents; Islam; Male; Metformin; Middle Aged; Nitriles; Pyrrolidines; Treatment Outcome; Vildagliptin | 2009 |
Comparison of metformin, gliclazide MR and rosiglitazone in monotherapy and in combination for type 2 diabetes.
Topics: Adult; Aged; Analysis of Variance; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Retrospective Studies; Rosiglitazone; Thiazolidinediones | 2010 |
[Dynamics of structural-functional parameters of cardiovascular system during use of complex therapy of women with type 2 diabetes mellitus].
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Chi-Square Distribution; Data Interpretation, Statistical; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Humans; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Metformin; Middle Aged; Obesity, Abdominal; Risk Factors; Time Factors | 2010 |
Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Diet, Atherogenic; Gliclazide; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Metformin; Oxidative Stress; Rats | 2011 |
Comparison of the dipeptidyl peptidase-4 inhibitor vildagliptin and the sulphonylurea gliclazide in combination with metformin, in Muslim patients with type 2 diabetes mellitus fasting during Ramadan: results of the VECTOR study.
Topics: Adamantane; Cohort Studies; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Fasting; Female; Gliclazide; Humans; Hypoglycemic Agents; Islam; Male; Metformin; Middle Aged; Nitriles; Pyrrolidines; Sulfonylurea Compounds; Time Factors; Vildagliptin | 2011 |
Effects of pioglitazone add-on to gliclazide and metformin on glycemic control in patients with type 2 diabetes.
Topics: Adult; Aged; Blood Glucose; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Pioglitazone; Retrospective Studies; Thiazolidinediones | 2012 |
Glycaemic control and cost analysis when changing from gliclazide co-administered with metformin to pre-combined glibenclamide-metformin tablets in type 2 diabetes mellitus.
Topics: Blood Glucose; Costs and Cost Analysis; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glyburide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Retrospective Studies; Tablets | 2012 |
Rapid extraction, identification and quantification of oral hypoglycaemic drugs in serum and hair using LC-MS/MS.
Topics: Acetonitriles; Chromatography, Liquid; Female; Forensic Toxicology; Gliclazide; Glipizide; Glyburide; Hair; Humans; Hypoglycemic Agents; Limit of Detection; Male; Mass Spectrometry; Metformin; Methanol; Middle Aged; Molecular Structure; Solvents; Sulfonylurea Compounds | 2012 |
Mortality outcomes of different sulphonylurea drugs: the results of a 14-year cohort study of type 2 diabetic patients.
Topics: Adult; Aged; Cardiovascular Diseases; Cause of Death; Cohort Studies; Confounding Factors, Epidemiologic; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Follow-Up Studies; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Insulin; Kaplan-Meier Estimate; Male; Metformin; Middle Aged; Neoplasms; Odds Ratio; Proportional Hazards Models; Research Design; Retrospective Studies; Risk Assessment; Risk Factors; Sulfonylurea Compounds; Tolbutamide | 2013 |
Evaluation approach can significantly influence oral glucose-lowering drugs total mortality risks in retrospective cohorts of type 2 diabetes mellitus patients.
Topics: Diabetes Mellitus, Type 2; Gliclazide; Glyburide; Humans; Hypoglycemia; Hypoglycemic Agents; Metformin; Registries; Retrospective Studies; Risk Factors; Treatment Outcome; Ukraine | 2014 |
Fast and Simultaneous Analysis of Combined Anti-Diabetic Drugs by Capillary Zone Electrophoresis.
Topics: Drug Combinations; Electrophoresis, Capillary; Gliclazide; Glyburide; Hypoglycemic Agents; Limit of Detection; Linear Models; Metformin; Reproducibility of Results; Tablets | 2015 |
Metformin in combination with various insulin secretagogues in type 2 diabetes and associated risk of cardiovascular morbidity and mortality--a retrospective nationwide study.
Topics: Aged; Carbamates; Cardiovascular Diseases; Denmark; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glipizide; Glyburide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Morbidity; Myocardial Infarction; Piperidines; Registries; Retrospective Studies; Risk Factors; Stroke; Sulfonylurea Compounds; Tolbutamide | 2015 |
A severe case of vasoplegic shock following metformin overdose successfully treated with methylene blue as a last line therapy.
Topics: Acidosis; Adult; Drug Overdose; Fluid Therapy; Gliclazide; Humans; Male; Metformin; Methylene Blue; Shock; Vasoconstrictor Agents; Vasoplegia | 2015 |
Co-extrusion as a processing technique to manufacture a dual sustained release fixed-dose combination product.
Topics: Delayed-Action Preparations; Drug Combinations; Drug Compounding; Gliclazide; Hot Temperature; Hydrophobic and Hydrophilic Interactions; Hypoglycemic Agents; Kinetics; Metformin; Molecular Weight; Polyesters; Povidone; Solubility; Technology, Pharmaceutical | 2016 |
Effect of incretin therapies compared to pioglitazone and gliclazide in non-alcoholic fatty liver disease in diabetic patients not controlled on metformin alone: An observational, pilot study.
Topics: Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Exenatide; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Incretins; Lipids; Liraglutide; Liver Function Tests; Male; Metabolic Syndrome; Metformin; Middle Aged; Non-alcoholic Fatty Liver Disease; Peptides; Pilot Projects; Pioglitazone; Prospective Studies; Sitagliptin Phosphate; Thiazolidinediones; Venoms; Waist Circumference | 2016 |
A case of bullous pemphigoid ınduced by vildagliptin.
Topics: Adamantane; Administration, Cutaneous; Clobetasol; Complement C3; Diabetes Mellitus, Type 2; Dipeptidyl-Peptidase IV Inhibitors; Drug Eruptions; Female; Fluorescent Antibody Technique; Gliclazide; Glucocorticoids; Humans; Hypoglycemic Agents; Metformin; Middle Aged; Nitriles; Pemphigoid, Bullous; Pyrrolidines; Skin; Vildagliptin; Withholding Treatment | 2017 |
Treatment of Type 2 Diabetes with a Breakable Extended Release Gliclazide Formulation in Primary Care: The Xrise Study.
Topics: Adult; Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; India; Male; Metformin; Middle Aged; Primary Health Care; Prospective Studies; Tablets; Treatment Outcome | 2015 |
Rapid Onset of Diabetic Ketoacidosis After SGLT2 Inhibition in a Patient With Unrecognized Acromegaly.
Topics: Adenoma; Benzhydryl Compounds; Diabetes Mellitus, Type 2; Diabetic Ketoacidosis; Drug Therapy, Combination; Fatty Acids, Nonesterified; Gliclazide; Glucagon; Glucosides; Growth Hormone-Secreting Pituitary Adenoma; Humans; Hypoglycemic Agents; Insulin; Ketone Bodies; Male; Metformin; Middle Aged; Severity of Illness Index; Sitagliptin Phosphate; Sodium-Glucose Transporter 2 Inhibitors | 2017 |
Missed Opportunities for Deprescription: A Teachable Moment.
Topics: Aged, 80 and over; Deprescriptions; Diabetes Complications; Diabetes Mellitus; Drug Therapy, Combination; Gliclazide; Humans; Hypertension; Hypoglycemia; Hypoglycemic Agents; Kidney Failure, Chronic; Male; Metformin; Multimorbidity; Polypharmacy; Treatment Outcome | 2017 |
Epidemiologic Surveillance of Glycemic Response to a Scored, Breakable, Extended Release, Fixed Dose Combination of Gliclazide and Metformin in Persons with Type 2 Diabetes.
Topics: Blood Glucose; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Combinations; Female; Gliclazide; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Population Surveillance; Prospective Studies; Tablets | 2017 |
Efficacy and safety of replacing sitagliptin with canagliflozin in real-world patients with type 2 diabetes uncontrolled with sitagliptin combined with metformin and/or gliclazide: The SITA-CANA Switch Study.
Topics: Aged; Blood Glucose; Blood Pressure; Body Weight; Canagliflozin; Diabetes Mellitus, Type 2; Female; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Male; Metformin; Middle Aged; Retrospective Studies; Sitagliptin Phosphate | 2018 |
Development and validation of a new analytical HPLC method for simultaneous determination of the antidiabetic drugs, metformin and gliclazide.
Topics: Chromatography, High Pressure Liquid; Gliclazide; Hypoglycemic Agents; Limit of Detection; Metformin; Sensitivity and Specificity | 2019 |
Antidiabetic effect of mangiferin in combination with oral hypoglycemic agents metformin and gliclazide.
Topics: Administration, Oral; Animals; Diabetes Mellitus, Experimental; Drug Therapy, Combination; Enzymes; Gene Expression Regulation; Gliclazide; Hep G2 Cells; Humans; Hypoglycemic Agents; Insulin; Liver; Male; Metformin; Rats, Sprague-Dawley; Xanthones | 2019 |
Optimization of a single HPLC-PDA method for quantifying Metformin, Gliclazide, Pioglitazone, Dapagliflozin, Empagliflozin, Saxagliptin, Linagliptin and Teneligliptin using central composite design.
Topics: Adamantane; Benzhydryl Compounds; Chromatography, High Pressure Liquid; Dipeptides; Dose-Response Relationship, Drug; Gliclazide; Glucosides; Linagliptin; Metformin; Molecular Structure; Pioglitazone; Pyrazoles; Software; Structure-Activity Relationship; Thiazolidines | 2019 |
Maternal and Neonatal Health Outcomes Associated with the Use of Gliclazide and Metformin for the Treatment of Diabetes in Pregnancy: A Record Linkage Study.
Topics: Abnormalities, Drug-Induced; Adult; Diabetes, Gestational; Female; Gliclazide; Hospitalization; Humans; Hypoglycemia; Hypoglycemic Agents; Incidence; Infant, Newborn; Infant, Newborn, Diseases; Medical Record Linkage; Metformin; New South Wales; Outcome Assessment, Health Care; Pregnancy; Pregnancy in Diabetics; Pregnancy Outcome | 2020 |
Preclinical and clinical results regarding the effects of a plant-based antidiabetic formulation versus well established antidiabetic molecules.
Topics: Aged; Animals; Blood Glucose; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Female; Flavonoids; Fruit; Gliclazide; Humans; Hypoglycemic Agents; Liver; Magnoliopsida; Male; Metformin; Middle Aged; Oxidative Stress; Phytotherapy; Plant Extracts; Polyphenols; Rats, Wistar | 2019 |
Positive interaction of mangiferin with selected oral hypoglycemic drugs: a therapeutic strategy to alleviate diabetic nephropathy in experimental rats.
Topics: Animals; Antioxidants; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Drug Therapy, Combination; Gliclazide; Hypoglycemic Agents; Kidney; Kidney Function Tests; Male; Metformin; NF-kappa B; Oxidative Stress; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha; Xanthones | 2020 |
Comparative effectiveness of gliclazide modified release versus sitagliptin as second-line treatment after metformin monotherapy in patients with uncontrolled type 2 diabetes.
Topics: Adult; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Gliclazide; Glycated Hemoglobin; Humans; Hypoglycemic Agents; Metformin; Retrospective Studies; Sitagliptin Phosphate; Treatment Outcome | 2020 |
Visualized analysis and evaluation of simultaneous controlled release of metformin hydrochloride and gliclazide from sandwiched osmotic pump capsule.
Topics: Animals; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Dogs; Drug Delivery Systems; Gliclazide; Metformin; Osmosis; Solubility; Tablets | 2020 |
Sensitive detection of antidiabetic compounds and one degradation product in wastewater samples by a new SPE-LC-MS/MS method.
Topics: Chromatography, Liquid; Environmental Monitoring; Gliclazide; Glipizide; Glyburide; Hypoglycemic Agents; Metformin; Reproducibility of Results; Solid Phase Extraction; Sulfonylurea Compounds; Tandem Mass Spectrometry; Wastewater; Water Pollutants, Chemical | 2021 |
The role of nursing care in the type 2 diabetes treatment associated with chronic liver diseases.
Topics: Diabetes Mellitus, Type 2; Exenatide; Gliclazide; Humans; Hypoglycemic Agents; Liraglutide; Metformin; Non-alcoholic Fatty Liver Disease; Pioglitazone; Sitagliptin Phosphate | 2022 |
Crude extract from
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Euphorbia; Gliclazide; Glyburide; Hypoglycemic Agents; Insulin; Metformin; Plant Extracts; Rats | 2023 |
Analytical Method Capable of Quantifying Eight Nitrosamine Impurities from Five Different Commercially Available Metformin Formulations with Glipizide, Glibenclamide, Gliclazide, Evogliptin, and Glimepiride by Ultra High Performance Liquid Chromatography
Topics: Chromatography, High Pressure Liquid; Chromatography, Liquid; Diabetes Mellitus, Type 2; Gliclazide; Glipizide; Glyburide; Humans; Metformin; Nitrosamines; Pharmaceutical Preparations; Tandem Mass Spectrometry | 2023 |
[Characteristics of purchases of hypoglycemic agents in pharmacy retail sector in 2016-2020 years dynamics].
Topics: Dipeptidyl Peptidase 4; Gliclazide; Glyburide; Humans; Hypoglycemic Agents; Metformin; Pharmacies; Pharmacy | 2023 |