glaucocalyxin-a and imazodan

glaucocalyxin-a has been researched along with imazodan* in 1 studies

Other Studies

1 other study(ies) available for glaucocalyxin-a and imazodan

Article	Year
Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993, Volume: 14, Issue:4 Glaucocalyxin A (Gla A) is a new diterpenoid isolated from ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in Northeastern China. When incubated with washed rabbit platelets, Gla A inhibited ADP-, AA-, and PAF-induced aggregation of rabbit platelets with IC50 values of 3.44, 13.32, and 7.74 mumol.L-1, respectively. Gla A 10 and 100 mumol.L-1 increased the cAMP levels in platelets. In combination with imazodan hydrochloride, Gla A (1-100 mumol.L-1) caused a marked increase of platelet cAMP levels, while no effect with PGE1. Topics: Animals; Cyclic AMP; Diterpenes, Kaurane; Drugs, Chinese Herbal; Female; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridazines; Rabbits	1993

Article

Year

Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro.

Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1993, Volume: 14, Issue:4

Glaucocalyxin A (Gla A) is a new diterpenoid isolated from ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in Northeastern China. When incubated with washed rabbit platelets, Gla A inhibited ADP-, AA-, and PAF-induced aggregation of rabbit platelets with IC50 values of 3.44, 13.32, and 7.74 mumol.L-1, respectively. Gla A 10 and 100 mumol.L-1 increased the cAMP levels in platelets. In combination with imazodan hydrochloride, Gla A (1-100 mumol.L-1) caused a marked increase of platelet cAMP levels, while no effect with PGE1.

Topics: Animals; Cyclic AMP; Diterpenes, Kaurane; Drugs, Chinese Herbal; Female; Male; Platelet Activating Factor; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyridazines; Rabbits

1993