Page last updated: 2024-09-03

glabridin and verapamil

glabridin has been researched along with verapamil in 3 studies

Compound Research Comparison

Studies (glabridin)	Trials (glabridin)	Recent Studies (post-2010) (glabridin)	Studies (verapamil)	Trials (verapamil)	Recent Studies (post-2010) (verapamil)
172	4	122	17,621	1,527	2,067

Protein Interaction Comparison

Protein	Taxonomy	verapamil (IC50)
Solute carrier family 22 member 1	Homo sapiens (human)	6.8
Voltage-dependent L-type calcium channel subunit alpha-1F	Homo sapiens (human)	0.2
5-hydroxytryptamine receptor 4	Cavia porcellus (domestic guinea pig)	0.297
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	2
ATP-dependent translocase ABCB1	Homo sapiens (human)	2.2346
Cytochrome P450 3A4	Homo sapiens (human)	3.8008
Alpha-2A adrenergic receptor	Homo sapiens (human)	0.579
5-hydroxytryptamine receptor 1A	Rattus norvegicus (Norway rat)	3.02
ATP-dependent translocase ABCB1	Mus musculus (house mouse)	10
Catechol O-methyltransferase	Homo sapiens (human)	0.2
Potassium voltage-gated channel subfamily A member 3	Homo sapiens (human)	8
Histamine H2 receptor	Homo sapiens (human)	2.59
5-hydroxytryptamine receptor 2A	Homo sapiens (human)	0.442
5-hydroxytryptamine receptor 2C	Homo sapiens (human)	0.297
5-hydroxytryptamine receptor 1B	Rattus norvegicus (Norway rat)	3.02
Sodium-dependent serotonin transporter	Homo sapiens (human)	0.24
Multidrug resistance-associated protein 1	Homo sapiens (human)	5.598
D(3) dopamine receptor	Homo sapiens (human)	0.186
5-hydroxytryptamine receptor 2B	Homo sapiens (human)	0.165
5-hydroxytryptamine receptor 7	Cavia porcellus (domestic guinea pig)	6.8
Voltage-dependent L-type calcium channel subunit alpha-1D	Homo sapiens (human)	0.2
Potassium voltage-gated channel subfamily H member 2	Homo sapiens (human)	0.3945
Voltage-dependent L-type calcium channel subunit alpha-1S	Homo sapiens (human)	0.2
Voltage-dependent L-type calcium channel subunit alpha-1C	Homo sapiens (human)	0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens (human)	1.1934

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Dansette, PM; Fontana, E; Poli, SM	1
Cao, J; Chan, E; Chen, X; Huang, M; Li, XT; Liang, J; Sheu, FS; Wei, D; Wen, JY; Xu, AL; Yu, XQ; Yu, XY; Zhou, SF	1
Cao, J; Chan, E; Chen, X; Chowbay, B; Duan, W; Li, CG; Li, XT; Liang, J; Lin, SG; Wen, JY; Xue, CC; Yu, XQ; Yu, XY; Zhou, SF; Zhou, ZW	1

Reviews

1 review(s) available for glabridin and verapamil

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005

Other Studies

2 other study(ies) available for glabridin and verapamil

Article	Year
Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra. Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:4 Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Availability; Biological Transport, Active; Caco-2 Cells; Cell Membrane Permeability; Digoxin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Glucuronides; Glycyrrhiza; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Isoflavones; Mice; Mice, Knockout; Microsomes, Liver; Models, Biological; Molecular Structure; Phenols; Plant Roots; Rats; Rats, Sprague-Dawley; Time Factors; Transfection; Uridine Diphosphate Glucuronic Acid; Verapamil	2007
Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra. Pharmaceutical research, 2007, Volume: 24, Issue:9 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cells, Cultured; Endothelial Cells; Isoflavones; Male; Mice; Mice, Knockout; Permeability; Phenols; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil	2007

Article

Year

Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra.

Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:4

Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Availability; Biological Transport, Active; Caco-2 Cells; Cell Membrane Permeability; Digoxin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Glucuronides; Glycyrrhiza; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Isoflavones; Mice; Mice, Knockout; Microsomes, Liver; Models, Biological; Molecular Structure; Phenols; Plant Roots; Rats; Rats, Sprague-Dawley; Time Factors; Transfection; Uridine Diphosphate Glucuronic Acid; Verapamil

2007

Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra.

Pharmaceutical research, 2007, Volume: 24, Issue:9

Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cells, Cultured; Endothelial Cells; Isoflavones; Male; Mice; Mice, Knockout; Permeability; Phenols; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil

2007