Page last updated: 2024-09-03

glabridin and verapamil

glabridin has been researched along with verapamil in 3 studies

Compound Research Comparison

Studies
(glabridin)
Trials
(glabridin)
Recent Studies (post-2010)
(glabridin)
Studies
(verapamil)
Trials
(verapamil)
Recent Studies (post-2010) (verapamil)
172412217,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomyglabridin (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dansette, PM; Fontana, E; Poli, SM1
Cao, J; Chan, E; Chen, X; Huang, M; Li, XT; Liang, J; Sheu, FS; Wei, D; Wen, JY; Xu, AL; Yu, XQ; Yu, XY; Zhou, SF1
Cao, J; Chan, E; Chen, X; Chowbay, B; Duan, W; Li, CG; Li, XT; Liang, J; Lin, SG; Wen, JY; Xue, CC; Yu, XQ; Yu, XY; Zhou, SF; Zhou, ZW1

Reviews

1 review(s) available for glabridin and verapamil

ArticleYear
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
    Current drug metabolism, 2005, Volume: 6, Issue:5

    Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic

2005

Other Studies

2 other study(ies) available for glabridin and verapamil

ArticleYear
Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:4

    Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Availability; Biological Transport, Active; Caco-2 Cells; Cell Membrane Permeability; Digoxin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Glucuronides; Glycyrrhiza; Humans; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Isoflavones; Mice; Mice, Knockout; Microsomes, Liver; Models, Biological; Molecular Structure; Phenols; Plant Roots; Rats; Rats, Sprague-Dawley; Time Factors; Transfection; Uridine Diphosphate Glucuronic Acid; Verapamil

2007
Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra.
    Pharmaceutical research, 2007, Volume: 24, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cells, Cultured; Endothelial Cells; Isoflavones; Male; Mice; Mice, Knockout; Permeability; Phenols; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil

2007