Page last updated: 2024-09-03

ginsenoside rh2 and ginsenoside rg3

ginsenoside rh2 has been researched along with ginsenoside rg3 in 29 studies

Compound Research Comparison

Studies
(ginsenoside rh2)
Trials
(ginsenoside rh2)
Recent Studies (post-2010)
(ginsenoside rh2)
Studies
(ginsenoside rg3)
Trials
(ginsenoside rg3)
Recent Studies (post-2010) (ginsenoside rg3)
29512004439322

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (3.45)18.2507
2000's11 (37.93)29.6817
2010's16 (55.17)24.3611
2020's1 (3.45)2.80

Authors

AuthorsStudies
Ersam, T; Fatmawati, S; Jin, F; Shimizu, K; Yu, H; Zhang, C1
Ma, LY; Xu, W; Yang, XW; Zhang, YB; Zhou, QL1
Kashimoto, T; Kudo, K; Tachikawa, E; Takahashi, E1
Choi, KJ; Im, DS; Kim, HS; Ko, SR; Lee, EH; Park, JH1
Chen, X; Li, K; Li, X; Xu, J; Zhong, D1
Jiang, XL; Li, H; Sun, JG; Tucker, I; Wang, GJ; Wang, R; Wang, W; Xie, HT; Xie, YY; Xu, MJ; Zhao, XC1
Bae, EA; Han, MJ; Kim, DH; Lee, HU1
Choo, MK; Chung, KC; Kim, DH; Kim, S; Lee, E; Nam, G; Rhim, H1
Bae, EA; Kim, DH; Kim, EJ; Kim, HS; Park, JS; Ryu, JH1
Bae, EA; Han, MJ; Kim, DH; Shin, YW1
Deng, SG; Liu, YM; Ou, RM; Wu, ZF; Xu, SJ; Yang, L; Zeng, X1
Han, SJ; Kim, DH; Kim, SW; Lee, YC; Trinh, HT1
Hill, DL; Rayburn, ER; Wang, H; Wang, W; Zhang, R; Zhao, Y1
Su, JH; Wang, ZL; Xu, JH1
Choi, HJ; Kim, DH; Kim, NJ; Kim, TW1
Du, W; He, TC; Li, B; Searle, J; Wang, CZ; Yuan, CS; Zhao, J1
Kang, HS; Kim, JS; Kim, SJ; Park, HM1
Hou, J; Li, W; Liu, L; Sung, C; Wang, C; Wang, Z; Xue, J; Zhang, D; Zheng, Y1
Bae, SH; Bae, SK; Jang, MJ; Kim, JY; Kim, SO; Seo, JH; Yoo, YH; Zheng, YF1
Bae, SH; Bae, SK; Jang, MJ; Kim, JY; Kim, SO; Oh, E; Park, JB; Yoo, YH; Yoon, KD; Zheng, YF1
Cheong, JH; Hong, MJ; Kim, H; Kim, HP; Kim, J; Kim, JW; Park, JH; Sung, SH; Yang, H; Yang, MH; Yoo, H1
Fan, Y; Liu, Q; Wang, P; Wei, W; Wei, Y; Yan, X; Yang, C; Yue, J; Zhang, L; Zhao, G; Zhou, Z1
Chen, Y; Gao, Y; Jin, Y; Li, X; Li, Y; Sun, T; Yang, J1
Chen, X; Ding, Y; Le, J; Li, X; Peng, M; Yang, Y; Yi, Y; Zhang, T1
Cui, CH; Han, NS; Im, WT; Kim, SC; Park, SK; Siddiqi, MZ1
Fang, JP; Liu, Y; Wang, M; Wang, YN; Wu, LM; Xia, T; Yao, JH; Zeng, QH; Zhang, XL; Zhou, CX1
Hou, J; Li, W; Wang, Z; Xue, J1
Bai, G; Guo, Y; Hou, Y; Jiang, M; Jiang, Z; Jiao, Y; Kim, U; Li, C; Ma, X; Wang, Z1
Han, W; Huang, W; Ma, Y; Sun, L; Wang, B; Wang, L; Yao, D1

Other Studies

29 other study(ies) available for ginsenoside rh2 and ginsenoside rg3

ArticleYear
20(S)-Ginsenoside Rh2 as aldose reductase inhibitor from Panax ginseng.
    Bioorganic & medicinal chemistry letters, 2014, Sep-15, Volume: 24, Issue:18

    Topics: Aldehyde Reductase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ginsenosides; Humans; Molecular Conformation; Panax; Plant Roots; Stereoisomerism; Structure-Activity Relationship

2014
SIRT1 activator isolated from artificial gastric juice incubate of total saponins in stems and leaves of Panax ginseng.
    Bioorganic & medicinal chemistry letters, 2018, 02-01, Volume: 28, Issue:3

    Topics: Enzyme Activators; Panax; Plant Leaves; Plant Stems; Saponins; Sirtuin 1; Stereoisomerism; Triterpenes

2018
Properties of ginseng saponin inhibition of catecholamine secretion in bovine adrenal chromaffin cells.
    European journal of pharmacology, 1998, Jan-12, Volume: 341, Issue:2-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cardiac Glycosides; Catecholamines; Cattle; Central Nervous System Agents; Chromaffin Cells; Dose-Response Relationship, Drug; Ginsenosides; Glycyrrhizic Acid; Oleanolic Acid; Panax; Plants, Medicinal; Sapogenins; Saponins

1998
Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells.
    Archives of pharmacal research, 2004, Volume: 27, Issue:4

    Topics: Antineoplastic Agents; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Ginsenosides; Growth Inhibitors; Humans; Male; Prostatic Neoplasms

2004
Liquid chromatography/tandem mass spectrometry for pharmacokinetic studies of 20(R)-ginsenoside Rg3 in dog.
    Rapid communications in mass spectrometry : RCM, 2005, Volume: 19, Issue:6

    Topics: Administration, Oral; Animals; Blood Chemical Analysis; Chromatography, Liquid; Dogs; Female; Ginsenosides; Injections, Intra-Arterial; Male; Mass Spectrometry; Metabolic Clearance Rate; Reproducibility of Results; Sapogenins; Sensitivity and Specificity; Triterpenes

2005
High performance liquid chromatographic-mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, Apr-25, Volume: 818, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Freezing; Ginsenosides; Rats; Rats, Sprague-Dawley; Sapogenins; Spectrometry, Mass, Electrospray Ionization; Triterpenes

2005
Hepatoprotective effect of 20(S)-ginsenosides Rg3 and its metabolite 20(S)-ginsenoside Rh2 on tert-butyl hydroperoxide-induced liver injury.
    Biological & pharmaceutical bulletin, 2005, Volume: 28, Issue:10

    Topics: Animals; Cell Line, Tumor; Ginsenosides; Humans; Liver; Mice; tert-Butylhydroperoxide

2005
20(S)-ginsenoside Rh2, a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons.
    European journal of pharmacology, 2006, Apr-24, Volume: 536, Issue:1-2

    Topics: Animals; Binding Sites; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Fetus; Ginsenosides; Hippocampus; Membrane Potentials; Molecular Structure; N-Methylaspartate; Neurons; Panax; Polyamines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stereoisomerism; Structure-Activity Relationship

2006
Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-gamma-stimulated BV-2 microglial cells.
    Planta medica, 2006, Volume: 72, Issue:7

    Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Ginsenosides; Interferon-gamma; Lipopolysaccharides; Mice; Microglia; Signal Transduction; Transcription Factor AP-1

2006
Inhibitory effects of Korean red ginseng and its genuine constituents ginsenosides Rg3, Rf, and Rh2 in mouse passive cutaneous anaphylaxis reaction and contact dermatitis models.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:9

    Topics: Animals; Cytokines; Dermatitis, Contact; Female; Ginsenosides; Male; Mice; NF-kappa B; Oxazolone; Panax; Passive Cutaneous Anaphylaxis; Plant Extracts; Prostaglandin-Endoperoxide Synthases; RNA, Messenger

2006
[Determination of ginsenoside Rd and its metabolites in rat urine by LC-MS].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2006, Volume: 41, Issue:8

    Topics: Administration, Oral; Animals; Chromatography, High Pressure Liquid; Ginsenosides; Injections, Intravenous; Male; Oxidation-Reduction; Panax; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization

2006
Bifidus fermentation increases hypolipidemic and hypoglycemic effects of red ginseng.
    Journal of microbiology and biotechnology, 2007, Volume: 17, Issue:7

    Topics: Administration, Oral; Animals; Bifidobacterium; Cholesterol; Dose-Response Relationship, Drug; Fermentation; Ginsenosides; Hypoglycemia; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Panax; Phytotherapy; Plant Extracts; Plant Oils; Plant Roots; Polyethylene Glycols; Polysaccharides; Saponins; Surface-Active Agents; Triglycerides; Zea mays

2007
20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action.
    British journal of cancer, 2008, Feb-26, Volume: 98, Issue:4

    Topics: Animals; Apoptosis; Biomarkers, Tumor; Cell Cycle; Cell Proliferation; Drugs, Chinese Herbal; Gene Expression Regulation, Neoplastic; Ginsenosides; Humans; In Vitro Techniques; Male; Mice; Mice, Nude; Prostate-Specific Antigen; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sapogenins; Survival Rate; Triterpenes; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2008
Improving enzymatic production of ginsenoside Rh2 from Rg3 by using nonionic surfactant.
    Applied biochemistry and biotechnology, 2010, Volume: 160, Issue:4

    Topics: Enzyme Stability; Fusarium; Ginsenosides; Glucosidases; Polyethylene Glycols; Surface-Active Agents

2010
Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model.
    Planta medica, 2009, Volume: 75, Issue:8

    Topics: Animals; Anti-Anxiety Agents; Anxiety; Behavior, Animal; Buspirone; Flumazenil; Ginsenosides; Male; Maze Learning; Mice; Panax; Phytotherapy; Piperazines; Plant Extracts; Plant Roots; Pyridines; Saponins

2009
Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.
    Cancer letters, 2011, Feb-28, Volume: 301, Issue:2

    Topics: Acetylcysteine; Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Caspase Inhibitors; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Free Radical Scavengers; Ginsenosides; HCT116 Cells; HEK293 Cells; Humans; Mutation; NF-kappa B; Reactive Oxygen Species; Signal Transduction; Tumor Suppressor Protein p53; Vacuoles

2011
Reactive oxygen species mediated ginsenoside Rg3- and Rh2-induced apoptosis in hepatoma cells through mitochondrial signaling pathways.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:8

    Topics: Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Ginsenosides; Humans; Liver Neoplasms; Mitochondria, Liver; Reactive Oxygen Species; Signal Transduction

2012
Microbial transformation of ginsenoside Rg3 to ginsenoside Rh2 by Esteya vermicola CNU 120806.
    World journal of microbiology & biotechnology, 2012, Volume: 28, Issue:4

    Topics: beta-Glucosidase; Biotransformation; Ginsenosides; Hydrogen-Ion Concentration; Hydrolysis; Ophiostomatales; Temperature

2012
Stereoselective determination of ginsenosides Rg3 and Rh2 epimers in rat plasma by LC-MS/MS: application to a pharmacokinetic study.
    Journal of separation science, 2013, Volume: 36, Issue:12

    Topics: Animals; Chromatography, High Pressure Liquid; Ginsenosides; Male; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Tandem Mass Spectrometry

2013
Pharmacokinetics and tissue distribution of ginsenoside Rh2 and Rg3 epimers after oral administration of BST204, a purified ginseng dry extract, in rats.
    Xenobiotica; the fate of foreign compounds in biological systems, 2014, Volume: 44, Issue:12

    Topics: Administration, Oral; Animals; Area Under Curve; Dose-Response Relationship, Drug; Ginsenosides; Male; Molecular Structure; Plant Extracts; Rats; Rats, Sprague-Dawley

2014
Stereoisomer-specific anticancer activities of ginsenoside Rg3 and Rh2 in HepG2 cells: disparity in cytotoxicity and autophagy-inducing effects due to 20(S)-epimers.
    Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Ginsenosides; Hep G2 Cells; Hepatocytes; Humans; Male; Rats, Sprague-Dawley; Stereoisomerism

2015
Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts.
    Metabolic engineering, 2015, Volume: 29

    Topics: Ginsenosides; Glucosyltransferases; Metabolic Engineering; Panax; Plant Proteins; Saccharomyces cerevisiae

2015
Semisynthesis and bioactive evaluation of oxidized products from 20(S)-ginsenoside Rg3, Rh2, protopanaxadiol (PPD) and their 20(R)-epimers as cytotoxic agents.
    Steroids, 2016, Volume: 106

    Topics: Antineoplastic Agents; Chemistry Techniques, Synthetic; Ginsenosides; HeLa Cells; Hep G2 Cells; Humans; Oxidation-Reduction; Sapogenins; Stereoisomerism; Structure-Activity Relationship; Triterpenes

2016
Stereoselective pharmacokinetic and metabolism studies of 20(S)- and 20(R)-ginsenoside Rg₃ epimers in rat plasma by liquid chromatography-electrospray ionization mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2016, Mar-20, Volume: 121

    Topics: Animals; Chromatography, Liquid; Ginsenosides; Male; Plasma; Rats; Rats, Sprague-Dawley; Sapogenins; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Tandem Mass Spectrometry

2016
Comparative analysis of the expression level of recombinant ginsenoside-transforming β-glucosidase in GRAS hosts and mass production of the ginsenoside Rh2-Mix.
    PloS one, 2017, Volume: 12, Issue:4

    Topics: Bacterial Proteins; beta-Glucosidase; Biotransformation; Cloning, Molecular; Corynebacterium glutamicum; Escherichia coli; Fungal Proteins; Gene Expression; Genetic Vectors; Ginsenosides; Hydrogen-Ion Concentration; Industrial Microbiology; Kinetics; Lactococcus lactis; Molecular Weight; Panax; Protein Engineering; Recombinant Proteins; Saccharomyces cerevisiae; Temperature

2017
Ginsenoside Rh2 and Rg3 inhibit cell proliferation and induce apoptosis by increasing mitochondrial reactive oxygen species in human leukemia Jurkat cells.
    Molecular medicine reports, 2017, Volume: 15, Issue:6

    Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Proliferation; Cell Survival; Gene Expression; Ginsenosides; Humans; Jurkat Cells; Matrix Metalloproteinases; Mitochondria; Reactive Oxygen Species

2017
Ginsenoside Rg3 and Rh2 protect trimethyltin-induced neurotoxicity via prevention on neuronal apoptosis and neuroinflammation.
    Phytotherapy research : PTR, 2018, Volume: 32, Issue:12

    Topics: Animals; Antioxidants; Apoptosis; Cell Death; Cells, Cultured; Embryo, Mammalian; Encephalitis; Ginsenosides; Neurons; Neuroprotection; Neuroprotective Agents; Neurotoxicity Syndromes; Oxidative Stress; Rats; Rats, Sprague-Dawley; Trimethyltin Compounds

2018
Quantitative Proteomics Combined with Affinity MS Revealed the Molecular Mechanism of Ginsenoside Antitumor Effects.
    Journal of proteome research, 2019, 05-03, Volume: 18, Issue:5

    Topics: Animals; Antineoplastic Agents, Phytogenic; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Tumor; Cell Survival; Ginsenosides; Guanosine Triphosphate; Humans; Lung Neoplasms; Molecular Docking Simulation; Neoplasm Proteins; Protein Binding; Protein Conformation; Proteomics; ras Proteins; Sapogenins

2019
Ginsenosides, potent inhibitors of sialyltransferase.
    Zeitschrift fur Naturforschung. C, Journal of biosciences, 2020, Jan-28, Volume: 75, Issue:1-2

    Topics: Gene Expression Regulation, Neoplastic; Ginsenosides; Hep G2 Cells; Humans; Liver Neoplasms; Molecular Docking Simulation; Sialic Acids; Sialyltransferases

2020