ginsenoside-rf and pirinixic-acid

ginsenoside-rf has been researched along with pirinixic-acid* in 1 studies

Other Studies

1 other study(ies) available for ginsenoside-rf and pirinixic-acid

ArticleYear
Ginsenoside Rf, a component of ginseng, regulates lipoprotein metabolism through peroxisome proliferator-activated receptor alpha.
    Biochemical and biophysical research communications, 2006, Jan-06, Volume: 339, Issue:1

    We investigated whether ginseng regulates lipoprotein metabolism by altering peroxisome proliferator-activated receptor alpha (PPARalpha)-mediated pathways, using a PPARalpha-null mouse model. Administration of ginseng extract, ginsenosides, and ginsenoside Rf (Rf) to wild-type mice not only significantly increased basal levels of hepatic apolipoprotein (apo) A-I and C-III mRNA compared with wild-type controls, but also substantially reversed the reductions in mRNA levels of apo A-I and C-III expected following treatment with the potent PPARalpha ligand Wy14,643. In contrast, no effect was detected in the PPARalpha-null mice. Testing of eight main ginsenosides on PPARalpha reporter gene expression indicated that Rf was responsible for the effects of ginseng on lipoprotein metabolism. Furthermore, the inhibition of PPARalpha-dependent transactivation by Rf seems to occur at the level of DNA binding. These results demonstrate that ginseng component Rf regulates apo A-I and C-III mRNA and the actions of Rf on lipoprotein metabolism are mediated via interactions with PPARalpha.

    Topics: Animals; Apolipoprotein A-I; Apolipoprotein C-III; Apolipoproteins C; Genes, Reporter; Ginsenosides; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Panax; Plant Extracts; PPAR alpha; Pyrimidines; RNA, Messenger

2006