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ginkgolide a and ginkgolide b

ginkgolide a has been researched along with ginkgolide b in 35 studies

Compound Research Comparison

Studies (ginkgolide a)	Trials (ginkgolide a)	Recent Studies (post-2010) (ginkgolide a)	Studies (ginkgolide b)	Trials (ginkgolide b)	Recent Studies (post-2010) (ginkgolide b)
76	2	42	843	20	162

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	18 (51.43)	29.6817
2010's	17 (48.57)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Chan, VW; Cheung, F; O, K; Siow, YL; Woo, CW	1
Kuribara, H; Maruyama, Y; Weintraub, ST; Yoshihama, T	1
Chiu, HL; Lin, HY; Yang, TC	1
Burgos, RA; Folch, H; Hancke, JL; Hermosilla, R; Hidalgo, MA; Matthei, SM	1
Liu, Q; Zhou, L	1
Chebib, M; Duke, RK; Huang, SH; Johnston, GA; Sasaki, K; Wada, K	1
Chen, E; Ding, C; Lindsay, RC; Zhou, W	1
Chen, CF; Lee, TF; Wang, LC	1
Jaracz, S; Malik, S; Nakanishi, K	1
Basilico, F; Bombardelli, E; De Palma, A; Mauri, P; Morazzoni, P; Pozzi, F; Riva, A; Rossoni, G	1
Wang, DP; Yuan, M; Zhang, XQ; Zhou, X	1
Aponte, M; Cramer, DW; Dai, Y; Edwards, D; Ho, MC; Huang, TN; Li, L; Vitonis, A; Ye, B	1
Cai, HB; Collins, X; Edeki, TI; He, N; Strom, SC; Xie, HG	1
Berova, N; Dzyuba, SV; He, J; Nakanishi, K; Petrovic, AG; Polavarapu, PL	1
Ding, C; Ge, Q; Xie, J; Zhi, X; Zhou, Z	1
Bi, HC; Chen, X; Deng, Y; Ding, L; He, F; Huang, M; Huang, ZY; Liu, YQ; Ou, ZM; Yu, JJ; Zhao, LZ; Zhou, SF	1
Chen, JH; Dong, FR; Liu, M; Liu, Y	1
Chen, X; Cheng, W; Fan, X; Li, Y; Shi, J; Wang, W; Xu, W; Yang, Y; Zhu, C	1
Bauer, R; Beubler, E; Dittrich, P; Feizlmayr, E; Pinl, F; Suter, A; Woelkart, K	1
Guo, Q; Jin, M; Lv, Y; Sun, X; Xiao, W; Zhang, X	1
Chen, SN; Lankin, DC; Napolitano, JG; Pauli, GF	1
Chen, C; Jamaluddin, S; Liang, Z; Lü, JM; Siwak, EB; Weakley, SM; Yan, S; Yao, Q	1
Jiang, CM; Li, D; Quan, WQ; Wan, HY; Wang, X; Wu, JL; Wu, KY	1
Cai, BC; Chai, C; Di, LQ; Huang, P; Li, JS; Li, W; Qian, XC; Zhang, L	1
Chen, Y; Kang, Q; Lan, Y; Li, H; Liu, N; Ma, Q; Wang, W; Wu, Q; Zhang, Q; Zhang, Y; Zhao, B	1
Ding, G; Geng, T; Ma, Z; Wang, ZZ; Xiao, W; Yu-an, B; Zhou, XW	1
Du, G; Lan, K; Li, XJ; Xu, L; Yang, K	1
Du, G; Lan, K; Li, XJ; Xu, L	1
Geng, T; Si, HH; Sun, XP; Xue, J; Zhao, J	1
Aa, J; Fei, F; Geng, J; Geng, T; Huang, W; Li, Y; Ouyang, B; Peng, Y; Wang, G; Wang, J; Wang, P; Wang, S; Wang, Z; Xiao, W	1
A, JY; Fei, F; Geng, JL; Geng, T; Huang, WZ; Jin, XL; Li, YJ; Ouyang, BC; Peng, Y; Wang, GJ; Wang, JK; Wang, P; Wang, SY; Wang, ZZ; Xiao, W; Zhao, YQ	1
Cao, L; Cao, ZY; Ke, ZP; Li, ZQ; Wang, KL; Wang, ZZ; Xiao, W	1
Aa, J; Aa, L; Fei, F; Liu, C; Tan, Z; Wang, G	1
Cao, L; Cao, ZY; Luo, YP; Wang, ZZ; Xiao, W; Zhang, H; Zhang, XZ	1
Bi, YA; Huang, WZ; Wang, ZZ; Xiao, W; Xu, FF	1

Trials

2 trial(s) available for ginkgolide a and ginkgolide b

Article	Year
LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts Correlation with pharmacological activity. Journal of pharmaceutical and biomedical analysis, 2006, Feb-24, Volume: 40, Issue:3 Topics: Adult; Animals; Biological Availability; Bronchoconstriction; Chromatography, Liquid; Diterpenes; Ginkgo biloba; Ginkgolides; Guinea Pigs; Histamine; Humans; Lactones; Male; Mass Spectrometry; Models, Molecular; Molecular Conformation; Ovalbumin; Plant Extracts; Platelet Activating Factor; Terpenes; Thromboxane B2	2006
Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans. Phytotherapy research : PTR, 2010, Volume: 24, Issue:3 Topics: Adult; Biological Availability; Cardiovascular Agents; Chromatography, High Pressure Liquid; Cyclopentanes; Female; Furans; Ginkgo biloba; Ginkgolides; Humans; Lactones; Male; Mass Spectrometry; Phytotherapy; Plant Extracts; Tablets; Young Adult	2010

Article

Year

LC-MS characterization of terpene lactones in plasma of experimental animals treated with Ginkgo biloba extracts Correlation with pharmacological activity.

Journal of pharmaceutical and biomedical analysis, 2006, Feb-24, Volume: 40, Issue:3

Topics: Adult; Animals; Biological Availability; Bronchoconstriction; Chromatography, Liquid; Diterpenes; Ginkgo biloba; Ginkgolides; Guinea Pigs; Histamine; Humans; Lactones; Male; Mass Spectrometry; Models, Molecular; Molecular Conformation; Ovalbumin; Plant Extracts; Platelet Activating Factor; Terpenes; Thromboxane B2

2006

Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.

Phytotherapy research : PTR, 2010, Volume: 24, Issue:3

Topics: Adult; Biological Availability; Cardiovascular Agents; Chromatography, High Pressure Liquid; Cyclopentanes; Female; Furans; Ginkgo biloba; Ginkgolides; Humans; Lactones; Male; Mass Spectrometry; Phytotherapy; Plant Extracts; Tablets; Young Adult

2010

Other Studies

33 other study(ies) available for ginkgolide a and ginkgolide b

Article	Year
Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide. Molecular and cellular biochemistry, 2003, Volume: 243, Issue:1-2 Topics: Antioxidants; Cell Line; Cyclopentanes; Diterpenes; Dose-Response Relationship, Drug; Furans; Ginkgolides; Homocysteine; Humans; Lactones; Macrophages; Models, Biological; Monocytes; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Superoxides; Time Factors	2003
An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice. Journal of natural products, 2003, Volume: 66, Issue:10 Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzodiazepines; Caffeine; Cyclopentanes; Diazepam; Diterpenes; Dose-Response Relationship, Drug; Furans; Ginkgo biloba; Ginkgolides; Lactones; Male; Maze Learning; Mice; Mice, Inbred Strains; Molecular Structure; Motor Activity; Phenobarbital; Plant Extracts; Plants, Medicinal; Sleep	2003
Determination of ginkgolide A, B, and bilobalide in biloba L. extracts by microdialysis-HPLC. Analytical and bioanalytical chemistry, 2004, Volume: 379, Issue:3 Topics: Calibration; Chromatography, High Pressure Liquid; Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Lactones; Microdialysis; Plant Extracts; Plant Leaves	2004
Determination of specific receptor sites for platelet activating factor in bovine neutrophils. American journal of veterinary research, 2004, Volume: 65, Issue:5 Topics: Animals; Azepines; Base Sequence; Blotting, Western; Cattle; Cyclooctanes; Diterpenes; DNA Primers; DNA, Complementary; Enzyme-Linked Immunosorbent Assay; Ginkgolides; HL-60 Cells; Humans; Kinetics; Lactones; Lignans; Molecular Sequence Data; Neutrophils; Platelet Activating Factor; Platelet Membrane Glycoproteins; Polycyclic Compounds; Radioligand Assay; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Triazoles; Tritium	2004
[Determination of GA, GB and GC in total lactone of ginkgo (TLG) raw material]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2004, Volume: 27, Issue:1 Topics: Chromatography, High Pressure Liquid; Diterpenes; Drugs, Chinese Herbal; Ginkgo biloba; Ginkgolides; Lactones; Pharmacognosy; Plant Leaves; Plants, Medicinal	2004
Ginkgolides, diterpene trilactones of Ginkgo biloba, as antagonists at recombinant alpha1beta2gamma2L GABAA receptors. European journal of pharmacology, 2004, Jun-28, Volume: 494, Issue:2-3 Topics: Animals; Diterpenes; Dose-Response Relationship, Drug; Electrophysiology; GABA Antagonists; Ginkgo biloba; Ginkgolides; Humans; Lactones; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Picrotoxin; Receptors, GABA-A; Recombinant Proteins; Sesterterpenes; Xenopus laevis	2004
A method for extraction and quantification of Ginkgo terpene trilactones. Analytical chemistry, 2004, Aug-01, Volume: 76, Issue:15 Topics: Chromatography, High Pressure Liquid; Diterpenes; Ginkgo biloba; Ginkgolides; Lactones; Plant Extracts; Plant Leaves; Terpenes	2004
Effect of ginkgolides on beta-amyloid-suppressed acetylocholine release from rat hippocampal slices. Phytotherapy research : PTR, 2004, Volume: 18, Issue:7 Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Diterpenes; Dose-Response Relationship, Drug; Ginkgo biloba; Ginkgolides; Hippocampus; Lactones; Male; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley	2004
Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts. Phytochemistry, 2004, Volume: 65, Issue:21 Topics: Cyclopentanes; Diterpenes; Furans; Ginkgo biloba; Ginkgolides; Lactones; Molecular Structure; Plant Extracts	2004
[Quantitative determination of ginkgolides by liquid chromatography-electrospray mass spectrometry]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2005, Volume: 30, Issue:24 Topics: Chromatography, Liquid; Cyclopentanes; Drugs, Chinese Herbal; Furans; Ginkgo biloba; Ginkgolides; Lactones; Plant Leaves; Plants, Medicinal; Spectrometry, Mass, Electrospray Ionization; Tablets	2005
Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence. Cancer letters, 2007, Jun-18, Volume: 251, Issue:1 Topics: Case-Control Studies; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Cystadenocarcinoma, Mucinous; Dose-Response Relationship, Drug; Female; Ginkgo biloba; Ginkgolides; Humans; Lactones; Logistic Models; Mass Spectrometry; Massachusetts; New Hampshire; Ovarian Neoplasms; Phytotherapy; Plant Extracts; Quercetin	2007
Induction of cyp3a in primary cultures of human hepatocytes by ginkgolides a and B. Clinical and experimental pharmacology & physiology, 2007, Volume: 34, Issue:7 Topics: Adult; Aged; Blotting, Western; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme Induction; Female; Ginkgolides; Hepatocytes; Herb-Drug Interactions; Humans; Hydroxylation; Lactones; Male; Middle Aged; Phenobarbital; Quercetin; Rifampin; Testosterone	2007
Spectroscopic investigation of Ginkgo biloba terpene trilactones and their interaction with amyloid peptide Abeta(25-35). Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2008, Volume: 69, Issue:4 Topics: Amyloid beta-Peptides; Circular Dichroism; Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Lactones; Peptides; Spectrophotometry, Infrared; Terpenes; Time Factors; Vibration	2008
Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2008, Mar-15, Volume: 864, Issue:1-2 Topics: Animals; Chromatography, High Pressure Liquid; Cyclopentanes; Female; Furans; Ginkgo biloba; Ginkgolides; Lactones; Male; Plant Extracts; Quality Control; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2008
Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats. Xenobiotica; the fate of foreign compounds in biological systems, 2008, Volume: 38, Issue:5 Topics: Animals; Cyclopentanes; Cytochrome P-450 Enzyme System; Enzyme Induction; Flavonoids; Furans; Gene Expression; Ginkgo biloba; Ginkgolides; Kaempferols; Lactones; Male; Microsomes, Liver; Plant Extracts; Quercetin; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	2008
[Optimized preparation of ginkgolides A and B long-circulating solid lipid nanoparticles by central composite design and response surface method]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2008, Volume: 28, Issue:5 Topics: Delayed-Action Preparations; Drug Compounding; Ginkgolides; Lactones; Liposomes; Nanoparticles	2008
Chemical constituents of the bark of Machilus wangchiana and their biological activities. Journal of natural products, 2009, Volume: 72, Issue:12 Topics: 4-Butyrolactone; Animals; Antineoplastic Agents, Phytogenic; Drugs, Chinese Herbal; Female; Flavonoids; Ginkgolides; Glucuronidase; Humans; Lactones; Lauraceae; Lignans; Molecular Structure; Neutrophils; Plant Bark; Rats; Sesquiterpenes; Stereoisomerism	2009
[Pharmacokinetics of ginkgolides sustained-release tablet]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2011, Volume: 36, Issue:8 Topics: Animals; Area Under Curve; Biological Availability; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Dogs; Ginkgolides; Lactones; Male; Mass Spectrometry; Quality Control; Tablets; Therapeutic Equivalency	2011
Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba. Magnetic resonance in chemistry : MRC, 2012, Volume: 50, Issue:8 Topics: Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Kaempferols; Lactones; Magnetic Resonance Spectroscopy; Molecular Structure; Protons; Quercetin; Reference Standards; Rutin; Stereoisomerism	2012
Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Medical science monitor : international medical journal of experimental and clinical research, 2012, Volume: 18, Issue:8 Topics: Cell Death; Cell-Free System; Dose-Response Relationship, Drug; Ginkgolides; HIV Infections; HIV Protease; HIV Protease Inhibitors; Humans; Jurkat Cells; Lactones; Salicylates	2012
Neuroprotection against permanent focal cerebral ischemia by ginkgolides A and B is associated with obstruction of the mitochondrial apoptotic pathway via inhibition of c-Jun N-terminal kinase in rats. Journal of neuroscience research, 2014, Volume: 92, Issue:2 Topics: Animals; Apoptosis; Blotting, Western; Brain Ischemia; Disease Models, Animal; Ginkgolides; Immunohistochemistry; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Lactones; Male; Mitochondria; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species	2014
Effects of food and gender on the pharmacokinetics of ginkgolides A, B, C and bilobalide in rats after oral dosing with ginkgo terpene lactones extract. Journal of pharmaceutical and biomedical analysis, 2014, Volume: 100 Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Chromatography, Reverse-Phase; Drug Stability; Fasting; Female; Food-Drug Interactions; Ginkgo biloba; Ginkgolides; Half-Life; Lactones; Male; Plant Extracts; Postprandial Period; Rats, Sprague-Dawley; Reproducibility of Results; Sex Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2014
Enhanced dissolution rate and oral bioavailability of Ginkgo biloba extract by preparing solid dispersion via hot-melt extrusion. Fitoterapia, 2015, Volume: 102 Topics: Animals; Biological Availability; Cyclopentanes; Furans; Ginkgo biloba; Ginkgolides; Kaempferols; Lactones; Male; Molecular Structure; Plant Extracts; Quercetin; Rats, Sprague-Dawley; Solubility	2015
Evaluation of in vitro inhibition and induction of cytochrome P450 activities by hydrolyzed ginkgolides. Journal of ethnopharmacology, 2014, Dec-02, Volume: 158 Pt A Topics: Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Ginkgo biloba; Ginkgolides; Hepatocytes; Humans; In Vitro Techniques; Inhibitory Concentration 50; Lactones; Male; Microsomes, Liver; Plant Leaves; RNA, Messenger	2014
Understanding the regioselective hydrolysis of ginkgolide B under physiological environment based on generation, detection, identification, and semi-quantification of the hydrolyzed products. Analytical and bioanalytical chemistry, 2015, Volume: 407, Issue:26 Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Female; Ginkgolides; Humans; Hydrolysis; Lactones; Male; Mass Spectrometry; Rats; Stereoisomerism	2015
Characterizations of the hydrolyzed products of ginkgolide A and ginkgolide B by liquid chromatography coupled with mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2016, Jan-25, Volume: 118 Topics: Chromatography, Liquid; Ginkgolides; Hydrolysis; Lactones; Mass Spectrometry; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2016
[Absolute bioavailability of ginkgolide compounds in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2015, Volume: 40, Issue:14 Topics: Animals; Biological Availability; Chromatography, High Pressure Liquid; Cyclopentanes; Furans; Ginkgolides; Lactones; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry	2015
Pharmacokinetics and tissue distribution of ginkgolide A, ginkgolide B, and ginkgolide K after intravenous infusion of ginkgo diterpene lactones in a rat model. Journal of pharmaceutical and biomedical analysis, 2016, Jul-15, Volume: 126 Topics: Administration, Intravenous; Animals; Area Under Curve; Biological Availability; Blood-Brain Barrier; Chromatography, Liquid; Dose-Response Relationship, Drug; Female; Ginkgolides; Half-Life; Infusions, Intravenous; Lactones; Male; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Tissue Distribution	2016
Pharmacokinetics of the prototype and hydrolyzed carboxylic forms of ginkgolides A, B, and K administered as a ginkgo diterpene lactones meglumine injection in beagle dogs. Chinese journal of natural medicines, 2017, Volume: 15, Issue:10 Topics: Animals; Dogs; Ginkgo biloba; Ginkgolides; Lactones; Plant Extracts; Tandem Mass Spectrometry	2017
[Effects of ginkgolide A, B and K on platelet aggregation]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2017, Volume: 42, Issue:24 Topics: Animals; Calcium; Cyclic AMP; Ginkgolides; Lactones; Platelet Aggregation; Rabbits	2017
The pharmacokinetics study of ginkgolide A, B and the effect of food on bioavailability after oral administration of ginkgolide extracts in beagle dogs. Biomedical chromatography : BMC, 2018, Volume: 32, Issue:6 Topics: Administration, Oral; Animal Feed; Animals; Biological Availability; Chromatography, Liquid; Dogs; Drug Stability; Eating; Female; Ginkgo biloba; Ginkgolides; Lactones; Linear Models; Male; Plant Extracts; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2018
[Effect of compatibility of ginkgolide A, ginkgolide B and ginkgolide K]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2018, Volume: 43, Issue:7 Topics: Animals; Brain Ischemia; Ginkgolides; Lactones; Platelet Activating Factor; Platelet Aggregation; Rats; Reperfusion Injury	2018
Applying risk management to analytical methods for the desorbing process of ginkgo diterpene lactone meglumine injection. Chinese journal of natural medicines, 2018, Volume: 16, Issue:5 Topics: Chemistry, Pharmaceutical; Drug Compounding; Drugs, Chinese Herbal; Ginkgolides; Injections; Lactones; Least-Squares Analysis; Meglumine; Reproducibility of Results; Risk Management; Spectrophotometry, Infrared	2018