germanium and tartaric-acid

In series of pharmacometrics research by determination of an optimum model of dosing is established that introduction of OKAGERM-4 in a dose of 96.8 mg/kg administered 40 minutes before the start of hypoxic damage realizes in maximum increase of estimated life expectancy of animals in hermetically sealed containers (65.57 min), ensuring a maximum effect of potential pharmacotherapeutic remedy - tartaric acid-based coordination compound of germanium with manganese. Thus, the results of pharmacometric research aimed to develop dosing regimen of OKAGERM-4 may be the base for future episodes of its pre-clinical study.

Topics: Animals; Coordination Complexes; Dose-Response Relationship, Drug; Germanium; Humans; Hypoxia; Injections, Intraperitoneal; Manganese; Models, Biological; Rats; Tartrates