germacrone and alantolactone

germacrone has been researched along with alantolactone* in 1 studies

Other Studies

1 other study(ies) available for germacrone and alantolactone

ArticleYear
The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells.
    Nutrients, 2020, Jun-08, Volume: 12, Issue:6

    The sesquiterpenes alantolactone (ATL) and germacrone (GER) are potential anticancer agents of natural origin. Their toxicity and biological activity have been evaluated using the differentiated HepaRG (dHepaRG) cells, a hepatocyte-like model. The half-maximal inhibitory concentrations of cell viability after 24-h treatment of dHepaRG cells are approximately 60 µM for ATL and 250 µM for GER. However, both sesquiterpenes induce reactive oxygen species (ROS) formation in non-toxic concentrations and significantly dysregulate the mRNA expression of several functional markers of mature hepatocytes. They similarly decrease the protein level of signal transducer and activator of transcription 3 (STAT3), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and their transcription target, intercellular adhesion molecule 1 (ICAM-1). Based on the results of a BATMAN-TCM analysis, the effects of sesquiterpenes on cholesterol and lipid metabolism were studied. Sesquiterpene-mediated dysregulation of both cholesterol and lipid metabolism was observed, during which these compounds influenced the protein expression of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and sterol regulatory element-binding protein 2 (SREBP-2), as well as the mRNA expression of

    Topics: Antineoplastic Agents, Phytogenic; Cell Survival; Cholesterol; Gene Expression; Hep G2 Cells; Humans; Hydroxymethylglutaryl CoA Reductases; Intercellular Adhesion Molecule-1; Lactones; Lipid Metabolism; Liver; NF-kappa B; Reactive Oxygen Species; RNA, Messenger; Sesquiterpenes, Eudesmane; Sesquiterpenes, Germacrane; STAT3 Transcription Factor; Sterol Regulatory Element Binding Protein 2

2020
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