Page last updated: 2024-08-24

geranylgeraniol and mevalonic acid

geranylgeraniol has been researched along with mevalonic acid in 62 studies

Research

Studies (62)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (3.23)	18.7374
1990's	24 (38.71)	18.2507
2000's	21 (33.87)	29.6817
2010's	12 (19.35)	24.3611
2020's	3 (4.84)	2.80

Authors

Authors	Studies
Armstrong, J; Fawell, EH; Giannakouros, T; Hancock, JF; Magee, AI; Newman, CM	1
Casey, PJ; Gilman, AG; Gutowski, S; Mumby, SM; Sternweis, PC	1
Cañada, FJ; Lai, RK; Perez-Sala, D; Rando, RR	1
Comley, JC; Jaffe, JJ	1
Bernini, F; Corsini, A; Fumagalli, R; Paoletti, R; Raiteri, M; Soma, MR	1
Bernini, F; Bonfadini, G; Fumagalli, R; Scurati, N	1
Andres, DA; Crick, DC; Waechter, CJ	2
Bellosta, S; Bernini, F; Bonfadini, G; Didoni, G; Fumagalli, R	1
Corsini, A; Fumagalli, R; Gabbiani, G; Mazzotti, M; Paoletti, R; Raiteri, M; Soma, MR	1
Belloni, P; Corsini, A; Folco, G; Fumagalli, R; Granata, A; Hernandez, A; Paoletti, R; Viganõ, T	1
Favre, G; Miquel, K; Pradines, A	1
Knöss, W; Reuter, B	1
Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A	1
Cunningham, GR; Marcelli, M; Padayatty, SJ; Shao, TC	1
Durham, SK; Flint, OP; Gregg, RE; Masters, BA	1
Colombo, C; Galli, C; Risé, P	1
Chen, J; Evans, RM; Forman, BM; Ruan, B; Schroepfer, GJ	1
Andres, DA; Crick, DC; Danesi, R; Macchia, M; Waechter, CJ	1
Croucher, PI; Helfrich, MH; Rogers, MJ; Russell, RG; Shipman, CM	1
Fisher, JE; Halasy, JM; Hughes, DE; Luckman, SP; Masarachia, PJ; Reszka, AA; Rodan, GA; Rogers, MJ; Russell, RG; Wesolowski, G	1
Foster, BA; Ghosh, PM; Ghosh-Choudhury, N; Greenberg, NM; Kreisberg, JI; Mott, GE; Moyer, ML; Thomas, CA	1
Andersson, B; Dallner, G; Parmryd, I	1
Fawcett, TW; Gorospe, M; Holbrook, NJ; Hudgins, WR; Shack, S	1
Halasy-Nagy, JM; Masarachia, PJ; Reszka, AA; Rodan, GA	1
Arpaia, M; Banfi, C; Mussoni, L; Sironi, L; Tremoli, E	1
Eguchi, K; Hamasaki, K; Ichikawa, T; Ida, H; Kajiya, Y; Kato, Y; Kawakami, A; Nakao, K; Nakata, K; Shigeno, M; Takeda, Y	1
Blank, MA; Mönkkönen, J; Pesonen, J; Phipps, RJ; Rogers, MJ; Suri, S; Taskinen, M	1
Hjertman, M; Larsson, O; Wejde, J	1
Buurman, SW; Frenkel, J; Houten, SM; Kuis, W; Mandey, SH; Rijkers, GT; Wanders, RJ; Waterham, HR	1
Ahmad, S; Ahmed, Z; Bhatia, V; Haskard, DO; Kinderlerer, A; Lidington, EA; Mankoff, R; Mason, JC; Randi, AM	1
Iguchi, T; Ikeda, Y; Kizaki, M; Miyakawa, Y; Yamamoto, K	1
Haslinger, B; Kleemann, R; Kooistra, T; Toet, KH	1
Frenkel, J; Houten, SM; Waterham, HR	1
Mönkkönen, J; Ollikainen, J; Taskinen, M; Töyräs, A	1
Chait, A; Meyers, CD; Tannock, LR; Wight, TN	1
DENNIS, DT; GRAEBE, JE; UPPER, CD; WEST, CA	1
Brown, MS; DeBose-Boyd, RA; Goldstein, JL; Sever, N; Song, BL; Yabe, D	1
Domínguez, A; Ruiz-Velasco, N; Vega, MA	1
Doitsidou, M; Farber, SA; Ho, SY; Raz, E; Thorpe, JL	1
Bernini, F; Favari, E; Rothblat, GH; Sposito, AC; Zanotti, I	1
Coleman, RE; Evans, CA; Holen, I; Neville-Webbe, HL; Rostami-Hodjegan, A	1
Deng, Y; DeRose, RA; Farber, SA; Ho, SY; Santana, E; Thorpe, JL	1
Karperien, M; Löwik, C; Papapoulos, S; van Beek, E	1
Huber, KM; Kotti, TJ; Pfeiffer, BE; Ramirez, DM; Russell, DW	1
Harten, SK; Haskard, DO; Johns, M; Kinderlerer, AR; Lidington, EA; Mason, JC; Maxwell, PH; Steinberg, R	1
Head, DD; Kotti, T; McKenna, CE; Russell, DW	1
Chang, HJ; Chang, JW; Li, YY; Liu, YC; Su, SP; Tsai, MC; Wang, CH; Yeh, KY	1
Dutta, D; Elfakhani, M; Fernandes, NV; Hynds, DL; Katuru, R; King, C; Mills, N; Mo, H	1
Li, L; Mans, RA; McMahon, LL	1
Capecchi, PL; Capperucci, C; Ferrata, P; Frediani, B; Galeazzi, M; Laghi-Pasini, F; Lazzerini, PE; Niccolini, S; Spreafico, A	1
Kang, YS; Lee, NY	1
Morris, AJ; Onono, F; Spielmann, HP; Subramanian, KL; Subramanian, T; Sunkara, M	1
Campisciano, G; Crovella, S; Girardelli, M; Kleiner, G; Knowles, A; Marcuzzi, A; Tricarico, PM; Valencic, E	1
Coates, DE; Cullinan, MP; Drummond, BK; Milne, T; Seymour, GJ; Zafar, S	1
Baj, G; Bortul, R; Celeghini, C; Girardelli, M; Loganes, C; Marcuzzi, A; Monasta, L; Piscianz, E; Zweyer, M	1
Biondo, G; Castaldello, P; Corsini, A; Ferri, N; Lupo, MG; Marchianò, S; Trenti, A	1
Abdullah, MI; Abed, MN; Richardson, A	1
Giriwono, PE; Ho, HJ; Ito, A; Komai, M; Shirakawa, H	1
Fruman, DA; Juarez, D	1
Bouitbir, J; Krähenbühl, S; Sanvee, GM	1
Bian, Q; Cai, C; Ding, L; Fang, J; Feng, T; Hu, Y; Li, C; Li, S; Li, Y; Liu, C; Liu, W; Sun, H; Sun, S; Tang, X; Wang, H; Wang, S; Wang, Z; Yan, G; Zhang, Y; Zhen, X; Zhou, J; Zuo, W	1

Reviews

3 review(s) available for geranylgeraniol and mevalonic acid

Article	Year
Isoprenoid biosynthesis in hereditary periodic fever syndromes and inflammation. Cellular and molecular life sciences : CMLS, 2003, Volume: 60, Issue:6 Topics: Cholesterol; Diterpenes; Familial Mediterranean Fever; Farnesol; Humans; Inflammation; Mevalonic Acid; Models, Biological; Mutation; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; Syndrome	2003
A novel function of geranylgeraniol in regulating testosterone production. Bioscience, biotechnology, and biochemistry, 2018, Volume: 82, Issue:6 Topics: Adenylyl Cyclases; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dietary Supplements; Diterpenes; Humans; Leydig Cells; Male; Mevalonic Acid; Progesterone; Signal Transduction; Terpenes; Testosterone	2018
Targeting the Mevalonate Pathway in Cancer. Trends in cancer, 2021, Volume: 7, Issue:6 Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Diterpenes; Farnesyltranstransferase; Feeding Behavior; Food-Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metabolic Networks and Pathways; Mevalonic Acid; Mice; Neoplasms; Pinocytosis; Polyisoprenyl Phosphates; Prenylation	2021

Other Studies

59 other study(ies) available for geranylgeraniol and mevalonic acid

Article	Year
Post-translational processing of Schizosaccharomyces pombe YPT proteins. The Journal of biological chemistry, 1992, Jun-05, Volume: 267, Issue:16 Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Diterpenes; DNA; Electrophoresis, Polyacrylamide Gel; Farnesol; Fungal Proteins; GTP-Binding Proteins; Hydroxylamine; Hydroxylamines; Methylation; Mevalonic Acid; Molecular Sequence Data; Oncogene Protein p21(ras); Protein Biosynthesis; Protein Processing, Post-Translational; rab GTP-Binding Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces	1992
G protein gamma subunits contain a 20-carbon isoprenoid. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:15 Topics: Adrenal Gland Neoplasms; Animals; Brain Chemistry; Cattle; Cell Line; Chromatography, Affinity; Chromatography, High Pressure Liquid; Diterpenes; GTP-Binding Proteins; Macromolecular Substances; Mevalonic Acid; Pheochromocytoma; Rats	1990
The gamma subunit of transducin is farnesylated. Proceedings of the National Academy of Sciences of the United States of America, 1990, Volume: 87, Issue:19 Topics: Animals; Cattle; Diterpenes; Farnesol; Gas Chromatography-Mass Spectrometry; In Vitro Techniques; Leucine; Macromolecular Substances; Mevalonic Acid; Protein Processing, Post-Translational; Retina; Transducin	1990
Isoprenoid biosynthesis in adult Brugia pahangi and Dirofilaria immitis. The Journal of parasitology, 1981, Volume: 67, Issue:5 Topics: Animals; Brugia; Cholesterol; Dirofilaria immitis; Diterpenes; Dolichols; Female; Filarioidea; Male; Mevalonic Acid; Palmitates; Terpenes; Ubiquinone; Vitamin K	1981
Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. The American journal of cardiology, 1995, Jul-13, Volume: 76, Issue:2 Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cell Division; Cell Movement; Cells, Cultured; Cholesterol Esters; Diterpenes; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Rats; Rats, Sprague-Dawley; Simvastatin	1995
HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages. Arteriosclerosis, thrombosis, and vascular biology, 1995, Volume: 15, Issue:9 Topics: Animals; Carbocyanines; Cholesterol Esters; Diterpenes; Endocytosis; Fatty Acids, Monounsaturated; Fluorescent Dyes; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Lovastatin; Macrophages, Peritoneal; Mevalonic Acid; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Simvastatin	1995
Farnesol is utilized for protein isoprenylation and the biosynthesis of cholesterol in mammalian cells. Biochemical and biophysical research communications, 1995, Jun-15, Volume: 211, Issue:2 Topics: Animals; Cell Line; Chlorocebus aethiops; Cholesterol; Cysteine; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Kinetics; Mevalonic Acid; Neoplasm Proteins; Protein Biosynthesis; Protein Prenylation; Proteins; Rats; Tritium; Tumor Cells, Cultured; Ubiquinone	1995
Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages. Atherosclerosis, 1993, Volume: 104, Issue:1-2 Topics: Acetylation; Animals; Anticholesteremic Agents; Cells, Cultured; Cholesterol; Cholesterol Esters; Diterpenes; Dose-Response Relationship, Drug; Esterification; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Lovastatin; Macrophages, Peritoneal; Mevalonic Acid; Mice; Mice, Inbred BALB C; Simvastatin	1993
Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. Atherosclerosis, 1993, Volume: 101, Issue:1 Topics: Acyclic Monoterpenes; Animals; Aorta; Cell Division; Cells, Cultured; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Fatty Acids, Monounsaturated; Femoral Artery; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Squalene; Terpenes	1993
Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation. European journal of pharmacology, 1995, Oct-15, Volume: 291, Issue:2 Topics: Bronchi; Cell Division; Diterpenes; Enzyme Inhibitors; Humans; Lovastatin; Lung; Mevalonic Acid; Muscle, Smooth; Simvastatin	1995
Farnesol and geranylgeraniol induce actin cytoskeleton disorganization and apoptosis in A549 lung adenocarcinoma cells. Biochemical and biophysical research communications, 1996, Aug-23, Volume: 225, Issue:3 Topics: Actins; Acyclic Monoterpenes; Apoptosis; Cholesterol; Cytoskeleton; Desmosterol; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Squalene; Terpenes; Tumor Cells, Cultured	1996
Biosynthesis of [14C]geranylgeranyldiphosphate by a prenyl transferase system from a mutant strain of Gibberella fujikuroi. Analytical biochemistry, 1996, Aug-01, Volume: 239, Issue:2 Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dimethylallyltranstransferase; Diterpenes; Gibberella; Hydrolysis; Mevalonic Acid; Mutagenesis; Oxidoreductases; Polyisoprenyl Phosphates	1996
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. Oncogene, 1996, Nov-07, Volume: 13, Issue:9 Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases	1996
Geranylgeraniol promotes entry of UT-2 cells into the cell cycle in the absence of mevalonate. Experimental cell research, 1997, Mar-15, Volume: 231, Issue:2 Topics: Animals; Cell Cycle; CHO Cells; Cricetinae; Cricetulus; Diterpenes; Farnesol; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Protein Prenylation; Protein Processing, Post-Translational; S Phase	1997
Lovastatin-induced apoptosis in prostate stromal cells. The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:5 Topics: Apoptosis; Cholesterol; Dihydrotestosterone; Diterpenes; DNA; Enzyme Inhibitors; Finasteride; Flow Cytometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Male; Mevalonic Acid; Prostate; Prostatic Hyperplasia; Stromal Cells; Testosterone	1997
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicology and applied pharmacology, 1997, Volume: 145, Issue:1 Topics: Analysis of Variance; Animals; Animals, Newborn; Anticholesteremic Agents; Butylamines; Cells, Cultured; Cholesterol; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Prodrugs; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Squalene; Sulfonic Acids	1997
Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. Journal of lipid research, 1997, Volume: 38, Issue:7 Topics: Acetates; Cell Line; Cholesterol; Diterpenes; Enzyme Inhibitors; Esterification; Fatty Acids, Unsaturated; Glycerol; Glycolipids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Linoleic Acid; Linoleic Acids; Lipids; Lovastatin; Mevalonic Acid; Monocytes; Simvastatin	1997
The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism. Proceedings of the National Academy of Sciences of the United States of America, 1997, Sep-30, Volume: 94, Issue:20 Topics: Cell Line; Diterpenes; DNA-Binding Proteins; Humans; Liver X Receptors; Mevalonic Acid; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Sterols	1997
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. Journal of neurochemistry, 1998, Volume: 70, Issue:6 Topics: Animals; Cell Division; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Molecular Weight; Nerve Tissue Proteins; Polyisoprenyl Phosphates; Protein Prenylation; Rats; Thymidine; Tumor Cells, Cultured	1998
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer research, 1998, Dec-01, Volume: 58, Issue:23 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Lovastatin; Mevalonic Acid; Multiple Myeloma; Protein Prenylation; Tumor Cells, Cultured	1998
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proceedings of the National Academy of Sciences of the United States of America, 1999, Jan-05, Volume: 96, Issue:1 Topics: Alendronate; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Cholesterol; Clodronic Acid; Diterpenes; Enzyme Activation; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Kinases; Rabbits; Skull; Squalene	1999
Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. Oncogene, 1999, Jul-15, Volume: 18, Issue:28 Topics: Actin Cytoskeleton; Adenocarcinoma; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Division; Cell Size; Diterpenes; Drug Interactions; Enzyme Activation; Farnesol; G1 Phase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Mice, Transgenic; Polyisoprenyl Phosphates; Prostatic Neoplasms; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rac GTP-Binding Proteins; rhoA GTP-Binding Protein; Sesquiterpenes; Tumor Cells, Cultured	1999
Protein prenylation in spinach chloroplasts. Proceedings of the National Academy of Sciences of the United States of America, 1999, Aug-31, Volume: 96, Issue:18 Topics: Animals; Cell Fractionation; Chloroplasts; Cotyledon; Diterpenes; Farnesol; Gas Chromatography-Mass Spectrometry; Mammals; Mevalonic Acid; Plant Proteins; Protein Prenylation; Protein Synthesis Inhibitors; Spinacia oleracea; Tritium	1999
Activation of the cholesterol pathway and Ras maturation in response to stress. Oncogene, 1999, Oct-28, Volume: 18, Issue:44 Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Cholesterol; Diterpenes; Farnesol; Genes, ras; Heat-Shock Response; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Male; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Prenylation; ras Proteins; Sterols; Stress, Physiological	1999
Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase. The Journal of biological chemistry, 1999, Dec-03, Volume: 274, Issue:49 Topics: Alendronate; Animals; Apoptosis; Calcium Channel Blockers; Caspase Inhibitors; Caspases; Clodronic Acid; Diphosphonates; Diterpenes; Enzyme Activation; Etidronic Acid; Macrophage Colony-Stimulating Factor; Male; MAP Kinase Kinase Kinases; Mevalonic Acid; Mice; Mice, Inbred BALB C; Osteoclasts; Protein Prenylation; Protein Serine-Threonine Kinases; Risedronic Acid; Signal Transduction; Staurosporine; Time Factors	1999
Fluvastatin inhibits basal and stimulated plasminogen activator inhibitor 1, but induces tissue type plasminogen activator in cultured human endothelial cells. Thrombosis and haemostasis, 2000, Volume: 84, Issue:1 Topics: Cells, Cultured; Depression, Chemical; Diterpenes; Endothelium, Vascular; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipopolysaccharides; Mevalonic Acid; Plasminogen Activator Inhibitor 1; RNA, Messenger; Tetradecanoylphorbol Acetate; Tissue Plasminogen Activator; Tumor Necrosis Factor-alpha; Umbilical Veins	2000
Geranylgeraniol, an intermediate product in mevalonate pathway, induces apoptotic cell death in human hepatoma cells: death receptor-independent activation of caspase-8 with down-regulation of Bcl-xL expression. Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:9 Topics: Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Diterpenes; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; Mevalonic Acid; Neoplasm Proteins; Oligopeptides; Proteins; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Tumor Cells, Cultured; Ursodeoxycholic Acid; X-Linked Inhibitor of Apoptosis Protein	2001
Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone, 2001, Volume: 29, Issue:4 Topics: Apoptosis; Caco-2 Cells; Cell Division; Cell Survival; Diphosphonates; Diterpenes; Epithelial Cells; Gastrointestinal Diseases; Humans; In Situ Nick-End Labeling; In Vitro Techniques; Mevalonic Acid; Nitrogen Compounds; Protein Prenylation; rap1 GTP-Binding Proteins	2001
Characterization of hydrophobic prenyl groups of isoprenylated proteins in human cancer cells. Biochemical and biophysical research communications, 2001, Nov-02, Volume: 288, Issue:3 Topics: Chromatography, High Pressure Liquid; Cysteine; Dimethylallyltranstransferase; Diterpenes; Humans; Mevalonic Acid; Neoplasm Proteins; Neoprene; Protein Prenylation; Tumor Cells, Cultured	2001
Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. Arthritis and rheumatism, 2002, Volume: 46, Issue:10 Topics: Antibodies; CD2 Antigens; CD28 Antigens; Cell Division; Cells, Cultured; Child; Diterpenes; Familial Mediterranean Fever; Farnesol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypergammaglobulinemia; Immunoglobulin D; Interleukin-1; Lovastatin; Male; Mevalonic Acid; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; T-Lymphocytes	2002
Statin-induced expression of decay-accelerating factor protects vascular endothelium against complement-mediated injury. Circulation research, 2002, Oct-18, Volume: 91, Issue:8 Topics: Atorvastatin; CD55 Antigens; Cell Line; Cells, Cultured; Complement Activation; Complement C3; Cytoprotection; Diterpenes; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Nitric Oxide; Phosphatidylinositol 3-Kinases; Polyisoprenyl Phosphates; Protein Kinase C; Pyrroles; rho GTP-Binding Proteins; RNA, Messenger; Simvastatin; Up-Regulation	2002
Nitrogen-containing bisphosphonates induce S-phase cell cycle arrest and apoptosis of myeloma cells by activating MAPK pathway and inhibiting mevalonate pathway. Cellular signalling, 2003, Volume: 15, Issue:7 Topics: Apoptosis; Cell Division; Cell Line, Tumor; Checkpoint Kinase 1; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Imidazoles; Interleukin-6; MAP Kinase Signaling System; Mevalonic Acid; Multiple Myeloma; Phosphorylation; Protein Kinases; S Phase; Signal Transduction; Stromal Cells	2003
Simvastatin suppresses tissue factor expression and increases fibrinolytic activity in tumor necrosis factor-alpha-activated human peritoneal mesothelial cells. Kidney international, 2003, Volume: 63, Issue:6 Topics: Antineoplastic Agents; Cells, Cultured; Diterpenes; Epithelial Cells; Epithelium; Fibrinolysis; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Omentum; Peritoneal Dialysis; Peritoneum; Peritonitis; Plasminogen Activator Inhibitor 1; Simvastatin; Thromboplastin; Tumor Necrosis Factor-alpha	2003
Inhibition of mevalonate pathway is involved in alendronate-induced cell growth inhibition, but not in cytokine secretion from macrophages in vitro. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2003, Volume: 19, Issue:4 Topics: Alendronate; Animals; Cell Division; Cell Line; Diterpenes; Farnesol; Lipopolysaccharides; Macrophages; Mevalonic Acid; Mice	2003
Statin-exposed vascular smooth muscle cells secrete proteoglycans with decreased binding affinity for LDL. Journal of lipid research, 2003, Volume: 44, Issue:11 Topics: Animals; Cell Count; Cells, Cultured; Diterpenes; Glucosamine; Haplorhini; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Methionine; Mevalonic Acid; Muscle, Smooth, Vascular; Protein Binding; Proteoglycans	2003
BIOSYNTHESIS OF GIBBERELLINS. I. THE BIOSYNTHESIS OF (-)-KAUREN-19-OL, AND TRANS-GERANYLGERANIOL IN ENDOSPERM NUCELLUS OF ECHINOCYSTIS MACROCARPA GREENE. The Journal of biological chemistry, 1965, Volume: 240 Topics: Adenosine Triphosphate; Carbon Isotopes; Catalysis; Chemistry Techniques, Analytical; Chromatography; Crystallization; Diterpenes; Endosperm; Gibberellins; Mevalonic Acid; Radiometry; Research; Seeds	1965
Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol. The Journal of biological chemistry, 2003, Dec-26, Volume: 278, Issue:52 Topics: Alanine; Amino Acid Sequence; Animals; Carrier Proteins; Cell Membrane; CHO Cells; Cricetinae; Diterpenes; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Farnesol; Hydroxymethylglutaryl CoA Reductases; Immunoblotting; Intracellular Signaling Peptides and Proteins; Lysine; Membrane Proteins; Mevalonic Acid; Molecular Sequence Data; Peptides; Plasmids; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Homology, Amino Acid; Sterols; Subcellular Fractions; Time Factors; Transfection; Ubiquitin	2003
Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. Biochemical pharmacology, 2004, Jan-15, Volume: 67, Issue:2 Topics: Actins; Anticholesteremic Agents; CD36 Antigens; Cells, Cultured; Cytoskeleton; Diterpenes; Farnesol; Gene Expression Regulation; Humans; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Monocytes; Receptors, Cytoplasmic and Nuclear; rho GTP-Binding Proteins; RNA, Messenger; Transcription Factors; Transcription, Genetic	2004
Germ cell migration in zebrafish is dependent on HMGCoA reductase activity and prenylation. Developmental cell, 2004, Volume: 6, Issue:2 Topics: Animals; Anticholesteremic Agents; Atorvastatin; Cell Movement; Chemokine CXCL12; Chemokines, CXC; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Nonmammalian; Enzyme Inhibitors; Farnesol; gamma-Glutamyltransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Mevalonic Acid; Microinjections; Morpholines; Protein Prenylation; Pyrroles; RNA-Binding Proteins; RNA, Messenger; Somites; Time Factors; Zebrafish; Zebrafish Proteins	2004
Pitavastatin increases ABCA1-mediated lipid efflux from Fu5AH rat hepatoma cells. Biochemical and biophysical research communications, 2004, Aug-27, Volume: 321, Issue:3 Topics: Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Biological Transport; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Lipid Metabolism; Liver Neoplasms; Mevalonic Acid; Quinolines; Rats	2004
Sequence- and schedule-dependent enhancement of zoledronic acid induced apoptosis by doxorubicin in breast and prostate cancer cells. International journal of cancer, 2005, Jan-20, Volume: 113, Issue:3 Topics: Antibiotics, Antineoplastic; Apoptosis; Breast Neoplasms; Diphosphonates; Diterpenes; Doxorubicin; Drug Synergism; Drug Therapy, Combination; Female; Humans; Imidazoles; Male; Mevalonic Acid; Prostatic Neoplasms; Time Factors; Tumor Cells, Cultured; Zoledronic Acid	2005
Lipid metabolism in zebrafish. Methods in cell biology, 2004, Volume: 76 Topics: 4-Chloro-7-nitrobenzofurazan; Alkyl and Aryl Transferases; Animals; Annexin A2; Atorvastatin; Azetidines; Boron Compounds; Caveolin 1; Caveolins; Cell Movement; Cholesterol; Diterpenes; DNA; Embryo, Nonmammalian; Ethylnitrosourea; Ezetimibe; Farnesol; Farnesyltranstransferase; Geranyltranstransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lovastatin; Mevalonic Acid; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphatidylethanolamines; Protein Binding; Protein Prenylation; Pyrroles; Simvastatin; Zebrafish	2004
Independent pathways in the modulation of osteoclastic resorption by intermediates of the mevalonate biosynthetic pathway: the role of the retinoic acid receptor. Bone, 2006, Volume: 38, Issue:2 Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Bone Resorption; Calcium; Diphosphonates; Diterpenes; Dose-Response Relationship, Drug; Drug Synergism; Female; Ibandronic Acid; Mevalonic Acid; Mice; Osteoclasts; Polyisoprenyl Phosphates; Pregnancy; Protein Prenylation; Receptors, Retinoic Acid	2006
Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proceedings of the National Academy of Sciences of the United States of America, 2006, Mar-07, Volume: 103, Issue:10 Topics: Animals; Brain; Cholesterol; Cholesterol 24-Hydroxylase; Diterpenes; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Learning; Long-Term Potentiation; Mevalonic Acid; Mice; Mice, Inbred C57BL; Mice, Knockout; Steroid Hydroxylases; Synaptic Transmission	2006
Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. Arthritis research & therapy, 2006, Volume: 8, Issue:4 Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Atorvastatin; CD55 Antigens; CD59 Antigens; Cells, Cultured; Cobalt; Cytoprotection; Deferoxamine; Diterpenes; Endothelial Cells; Endothelium, Vascular; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia; Iron Chelating Agents; Mevalonic Acid; Pyrroles; RNA, Messenger; Up-Regulation	2006
Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America, 2008, Aug-12, Volume: 105, Issue:32 Topics: Alkyl and Aryl Transferases; Animals; Apolipoproteins E; Cholesterol; Cholesterol 24-Hydroxylase; Dendrites; Disease Models, Animal; Diterpenes; Farnesol; Hippocampus; Hyperlipoproteinemia Type III; Learning; Long-Term Potentiation; Mevalonic Acid; Mice; Mice, Knockout; Prenylation; Steroid Hydroxylases; Time Factors; Transferases	2008
Zoledronic acid induces cell-cycle prolongation in murine lung cancer cells by perturbing cyclin and Ras expression. Anti-cancer drugs, 2011, Volume: 22, Issue:1 Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclins; Diphosphonates; Diterpenes; Down-Regulation; E2F Transcription Factors; Imidazoles; Lung Neoplasms; Mevalonic Acid; Mice; Mice, Inbred BALB C; Phosphorylation; Protein Transport; ras Proteins; Retinoblastoma Protein; Zoledronic Acid	2011
Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. Experimental biology and medicine (Maywood, N.J.), 2011, May-01, Volume: 236, Issue:5 Topics: 3T3-L1 Cells; Alkaline Phosphatase; Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Diterpenes; Humans; Lovastatin; Melanoma, Experimental; Mevalonic Acid; Mice; Vitamin E	2011
Simvastatin-mediated enhancement of long-term potentiation is driven by farnesyl-pyrophosphate depletion and inhibition of farnesylation. Neuroscience, 2012, Jan-27, Volume: 202 Topics: Alkyl and Aryl Transferases; Animals; Blotting, Western; CA1 Region, Hippocampal; Diterpenes; Electrophysiological Phenomena; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Long-Term Potentiation; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Phosphatidylinositol 3-Kinases; Polyisoprenyl Phosphates; Prenylation; Proto-Oncogene Proteins c-akt; Sesquiterpenes; Signal Transduction; Simvastatin	2012
Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells. Joint bone spine, 2013, Volume: 80, Issue:2 Topics: Aged; Bone Resorption; Cell Proliferation; Cell Survival; Cells, Cultured; Culture Media; Diterpenes; Farnesol; Femur Head; Fluorobenzenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-1beta; Interleukin-6; Mevalonic Acid; Middle Aged; Osteoblasts; Osteoporosis; Osteoprotegerin; Pyrimidines; RNA, Messenger; Rosuvastatin Calcium; Sulfonamides; Terpenes	2013
The effects of bisphosphonates on taurine transport in retinal capillary endothelial cells under high glucose conditions. Advances in experimental medicine and biology, 2013, Volume: 776 Topics: Animals; Biological Transport; Cell Line; Diphosphonates; Diterpenes; Endothelial Cells; Glucose; Metabolic Networks and Pathways; Mevalonic Acid; Rats; Retinal Vessels; Taurine; Time Factors; Tritium	2013
Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway. The Journal of biological chemistry, 2013, Sep-20, Volume: 288, Issue:38 Topics: Antineoplastic Agents; Cell Line, Tumor; Diterpenes; Farnesol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mutation; Neoplasms; Polyisoprenyl Phosphates; Protein Prenylation; Tumor Suppressor Protein p53	2013
Block of the mevalonate pathway triggers oxidative and inflammatory molecular mechanisms modulated by exogenous isoprenoid compounds. International journal of molecular sciences, 2014, Apr-22, Volume: 15, Issue:4 Topics: Animals; Apoptosis; Carotenoids; Carrier Proteins; Cell Line; Cytokines; Diterpenes; Humans; Lycopene; Mevalonate Kinase Deficiency; Mevalonic Acid; Mice; Mitochondria; Nitric Oxide; NLR Family, Pyrin Domain-Containing 3 Protein; Phytol; Terpenes	2014
Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2014, Volume: 43, Issue:9 Topics: Adult; Apoptosis; Bone Density Conservation Agents; Bone Morphogenetic Protein 2; Cell Culture Techniques; Cell Survival; Cells, Cultured; Diphosphonates; Diterpenes; Epiregulin; Farnesol; Female; Fibroblasts; Gene Expression Regulation; Gingiva; Humans; Imidazoles; Interferon-alpha; Mevalonic Acid; Microscopy, Electron, Transmission; Middle Aged; Neovascularization, Physiologic; Polyisoprenyl Phosphates; rhoB GTP-Binding Protein; Sesquiterpenes; Signal Transduction; Vascular Endothelial Growth Factor A; Zoledronic Acid	2014
Geranylgeraniol and Neurological Impairment: Involvement of Apoptosis and Mitochondrial Morphology. International journal of molecular sciences, 2016, Mar-11, Volume: 17, Issue:3 Topics: Apoptosis; Cell Line; Diterpenes; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonate Kinase Deficiency; Mevalonic Acid; Mitochondria; Models, Biological; Neurons; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress	2016
Geranylgeraniol prevents the simvastatin-induced PCSK9 expression: Role of the small G protein Rac1. Pharmacological research, 2017, Volume: 122 Topics: Anticholesteremic Agents; Caco-2 Cells; Diterpenes; Humans; Mevalonic Acid; Promoter Regions, Genetic; Proprotein Convertase 9; Protein Prenylation; rac1 GTP-Binding Protein; Signal Transduction; Simvastatin; Up-Regulation	2017
Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells. Scientific reports, 2017, 08-14, Volume: 7, Issue:1 Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Diterpenes; Female; Geranyltranstransferase; GTP Phosphohydrolases; Humans; Imidazoles; Leucine; Mevalonic Acid; Naphthalenes; Ovarian Neoplasms; Quinolines; Zoledronic Acid	2017
C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation. Biochemical pharmacology, 2021, Volume: 190 Topics: Animals; Anticholesteremic Agents; Cell Proliferation; Cell Survival; Diterpenes; Male; Mevalonic Acid; Mice; Mice, Inbred C57BL; Muscle Fibers, Skeletal; Random Allocation; Simvastatin	2021
Granulosa cell mevalonate pathway abnormalities contribute to oocyte meiotic defects and aneuploidy. Nature aging, 2023, Volume: 3, Issue:6 Topics: Aneuploidy; Animals; Female; Granulosa Cells; Meiosis; Mevalonic Acid; Mice; Oocytes	2023