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geranylgeraniol and lovastatin

geranylgeraniol has been researched along with lovastatin in 36 studies

Research

Studies (36)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	20 (55.56)	18.2507
2000's	12 (33.33)	29.6817
2010's	4 (11.11)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bernini, F; Corsini, A; Fumagalli, R; Paoletti, R; Raiteri, M; Soma, MR	1
Bernini, F; Bonfadini, G; Fumagalli, R; Scurati, N	1
Bellosta, S; Bernini, F; Bonfadini, G; Didoni, G; Fumagalli, R	1
Corsini, A; Fumagalli, R; Gabbiani, G; Mazzotti, M; Paoletti, R; Raiteri, M; Soma, MR	1
Belloni, P; Corsini, A; Folco, G; Fumagalli, R; Granata, A; Hernandez, A; Paoletti, R; Viganõ, T	1
Andres, DA; Crick, DC; Waechter, CJ	1
Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A	2
McGuire, TF; Sebti, SM	1
Cunningham, GR; Marcelli, M; Padayatty, SJ; Shao, TC	1
Durham, SK; Flint, OP; Gregg, RE; Masters, BA	1
Colombo, C; Galli, C; Risé, P	1
Ghidoni, JJ; Ghosh, PM; Ghosh-Choudhury, N; Kreisberg, JI; Mott, GE; Radnik, RA; Stapleton, ML	1
Andres, DA; Crick, DC; Danesi, R; Macchia, M; Waechter, CJ	1
Endres, M; Huang, P; Huang, Z; Laufs, U; Liao, JK; Moskowitz, MA; Nakamura, T	1
Croucher, PI; Helfrich, MH; Rogers, MJ; Russell, RG; Shipman, CM	1
Fisher, JE; Halasy, JM; Hughes, DE; Luckman, SP; Masarachia, PJ; Reszka, AA; Rodan, GA; Rogers, MJ; Russell, RG; Wesolowski, G	1
Foster, BA; Ghosh, PM; Ghosh-Choudhury, N; Greenberg, NM; Kreisberg, JI; Mott, GE; Moyer, ML; Thomas, CA	1
Fawcett, TW; Gorospe, M; Holbrook, NJ; Hudgins, WR; Shack, S	1
Bailey, R; Hamilton, AD; Harlan, JM; Kovach, NL; Liu, L; Moesner, P; Sebti, SM	1
Cheng, QF; Rao, PV; Zigler, JS	1
Bannerman, DD; Hamilton, AD; Harlan, JM; Li, X; Liu, L; Sebti, SM; Tupper, JC; Winn, RK	1
Hohl, RJ; Ownby, SE	2
Buurman, SW; Frenkel, J; Houten, SM; Kuis, W; Mandey, SH; Rijkers, GT; Wanders, RJ; Waterham, HR	1
Bloem, AC; Kamphuis, MM; Lokhorst, HM; van de Donk, NW; van Kessel, B	1
Chang, TC; Lee, WS; Wang, CY; Zhong, WB	1
Domínguez, A; Ruiz-Velasco, N; Vega, MA	1
Deng, Y; DeRose, RA; Farber, SA; Ho, SY; Santana, E; Thorpe, JL	1
Fernández-Hernando, C; Lasunción, MA; Suárez, Y	1
Mitrofan, LM; Mönkkönen, J; Pelkonen, J	1
Bosia, A; Campia, I; Ghigo, D; Lussiana, C; Pescarmona, G; Riganti, C	1
Dutta, D; Elfakhani, M; Fernandes, NV; Hynds, DL; Katuru, R; King, C; Mills, N; Mo, H	1
Hariharan, M; Karten, B; Mailman, T	1
Bianco, AM; Crovella, S; Girardelli, M; Marcuzzi, A; Monasta, L; Piscianz, E; Tricarico, PM; Vuch, J; Zanin, V	1
Hynds, DL; Kaimal, R; Mo, H; Reddy, J; Samuel, F; Segovia, V	1

Other Studies

36 other study(ies) available for geranylgeraniol and lovastatin

Article	Year
Pathogenesis of atherosclerosis and the role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. The American journal of cardiology, 1995, Jul-13, Volume: 76, Issue:2 Topics: Animals; Anticholesteremic Agents; Arteriosclerosis; Cell Division; Cell Movement; Cells, Cultured; Cholesterol Esters; Diterpenes; Farnesol; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Inbred BALB C; Muscle, Smooth, Vascular; Pravastatin; Rabbits; Rats; Rats, Sprague-Dawley; Simvastatin	1995
HMG-CoA reductase inhibitors reduce acetyl LDL endocytosis in mouse peritoneal macrophages. Arteriosclerosis, thrombosis, and vascular biology, 1995, Volume: 15, Issue:9 Topics: Animals; Carbocyanines; Cholesterol Esters; Diterpenes; Endocytosis; Fatty Acids, Monounsaturated; Fluorescent Dyes; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Lovastatin; Macrophages, Peritoneal; Mevalonic Acid; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Simvastatin	1995
Requirement for mevalonate in acetylated LDL induction of cholesterol esterification in macrophages. Atherosclerosis, 1993, Volume: 104, Issue:1-2 Topics: Acetylation; Animals; Anticholesteremic Agents; Cells, Cultured; Cholesterol; Cholesterol Esters; Diterpenes; Dose-Response Relationship, Drug; Esterification; Fatty Acids, Monounsaturated; Fluvastatin; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins, LDL; Lovastatin; Macrophages, Peritoneal; Mevalonic Acid; Mice; Mice, Inbred BALB C; Simvastatin	1993
Relationship between mevalonate pathway and arterial myocyte proliferation: in vitro studies with inhibitors of HMG-CoA reductase. Atherosclerosis, 1993, Volume: 101, Issue:1 Topics: Acyclic Monoterpenes; Animals; Aorta; Cell Division; Cells, Cultured; Cholesterol; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Fatty Acids, Monounsaturated; Femoral Artery; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Mevalonic Acid; Muscle, Smooth, Vascular; Pravastatin; Rats; Rats, Sprague-Dawley; Simvastatin; Squalene; Terpenes	1993
Mevalonate pathway and isoprenoids regulate human bronchial myocyte proliferation. European journal of pharmacology, 1995, Oct-15, Volume: 291, Issue:2 Topics: Bronchi; Cell Division; Diterpenes; Enzyme Inhibitors; Humans; Lovastatin; Lung; Mevalonic Acid; Muscle, Smooth; Simvastatin	1995
Geranylgeraniol restores cell proliferation to lovastatin treated C6 glial cells. SAAS bulletin, biochemistry and biotechnology, 1996, Volume: 9 Topics: Animals; Cell Division; Cell Line; Diterpenes; Enzyme Inhibitors; Farnesol; Haplorhini; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kidney; Lovastatin; Neuroglia; Rats	1996
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. The Journal of biological chemistry, 1996, Nov-01, Volume: 271, Issue:44 Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyltranstransferase; Kinetics; Lovastatin; Methionine; Mice; Phosphorylation; Phosphotyrosine; Protein Prenylation; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Structure-Activity Relationship; Transfection; Transferases	1996
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts. Oncogene, 1996, Nov-07, Volume: 13, Issue:9 Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases	1996
Geranylgeraniol potentiates lovastatin inhibition of oncogenic H-Ras processing and signaling while preventing cytotoxicity. Oncogene, 1997, Jan-23, Volume: 14, Issue:3 Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Diterpenes; Drug Synergism; Enzyme Activation; Genes, ras; Lovastatin; Mice; Protein Kinases; Signal Transduction; Transferases	1997
Lovastatin-induced apoptosis in prostate stromal cells. The Journal of clinical endocrinology and metabolism, 1997, Volume: 82, Issue:5 Topics: Apoptosis; Cholesterol; Dihydrotestosterone; Diterpenes; DNA; Enzyme Inhibitors; Finasteride; Flow Cytometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Male; Mevalonic Acid; Prostate; Prostatic Hyperplasia; Stromal Cells; Testosterone	1997
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro. Toxicology and applied pharmacology, 1997, Volume: 145, Issue:1 Topics: Analysis of Variance; Animals; Animals, Newborn; Anticholesteremic Agents; Butylamines; Cells, Cultured; Cholesterol; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Prodrugs; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Squalene; Sulfonic Acids	1997
Effects of simvastatin on the metabolism of polyunsaturated fatty acids and on glycerolipid, cholesterol, and de novo lipid synthesis in THP-1 cells. Journal of lipid research, 1997, Volume: 38, Issue:7 Topics: Acetates; Cell Line; Cholesterol; Diterpenes; Enzyme Inhibitors; Esterification; Fatty Acids, Unsaturated; Glycerol; Glycolipids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Linoleic Acid; Linoleic Acids; Lipids; Lovastatin; Mevalonic Acid; Monocytes; Simvastatin	1997
Lovastatin induces apoptosis by inhibiting mitotic and post-mitotic events in cultured mesangial cells. Biochimica et biophysica acta, 1997, Oct-30, Volume: 1359, Issue:1 Topics: Actins; Animals; Apoptosis; Bromodeoxyuridine; Cell Count; Cell Division; Cell Movement; Cell Size; Cells, Cultured; Diterpenes; Farnesol; Glomerular Mesangium; GTP-Binding Proteins; Lovastatin; Microscopy, Electron; Microscopy, Video; Mitosis; Protein Prenylation; Rats; rhoA GTP-Binding Protein	1997
Geranylgeraniol overcomes the block of cell proliferation by lovastatin in C6 glioma cells. Journal of neurochemistry, 1998, Volume: 70, Issue:6 Topics: Animals; Cell Division; Diterpenes; Electrophoresis, Polyacrylamide Gel; Farnesol; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Molecular Weight; Nerve Tissue Proteins; Polyisoprenyl Phosphates; Protein Prenylation; Rats; Thymidine; Tumor Cells, Cultured	1998
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America, 1998, Jul-21, Volume: 95, Issue:15 Topics: Animals; Anticholesteremic Agents; Cells, Cultured; Diterpenes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Attack, Transient; Lovastatin; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Simvastatin; Tumor Cells, Cultured; Up-Regulation	1998
The bisphosphonate incadronate (YM175) causes apoptosis of human myeloma cells in vitro by inhibiting the mevalonate pathway. Cancer research, 1998, Dec-01, Volume: 58, Issue:23 Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Division; Diphosphonates; Diterpenes; Enzyme Inhibitors; Farnesol; Humans; Lovastatin; Mevalonic Acid; Multiple Myeloma; Protein Prenylation; Tumor Cells, Cultured	1998
Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro. Proceedings of the National Academy of Sciences of the United States of America, 1999, Jan-05, Volume: 96, Issue:1 Topics: Alendronate; Animals; Bone Resorption; Cell Differentiation; Cells, Cultured; Cholesterol; Clodronic Acid; Diterpenes; Enzyme Activation; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Osteoclasts; Protein Kinases; Rabbits; Skull; Squalene	1999
Role of RhoA activation in the growth and morphology of a murine prostate tumor cell line. Oncogene, 1999, Jul-15, Volume: 18, Issue:28 Topics: Actin Cytoskeleton; Adenocarcinoma; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Division; Cell Size; Diterpenes; Drug Interactions; Enzyme Activation; Farnesol; G1 Phase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Mice, Transgenic; Polyisoprenyl Phosphates; Prostatic Neoplasms; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rac GTP-Binding Proteins; rhoA GTP-Binding Protein; Sesquiterpenes; Tumor Cells, Cultured	1999
Activation of the cholesterol pathway and Ras maturation in response to stress. Oncogene, 1999, Oct-28, Volume: 18, Issue:44 Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Cholesterol; Diterpenes; Farnesol; Genes, ras; Heat-Shock Response; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Male; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Prenylation; ras Proteins; Sterols; Stress, Physiological	1999
Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s). The Journal of biological chemistry, 1999, Nov-19, Volume: 274, Issue:47 Topics: Benzamides; Cell Adhesion; Diterpenes; Fibronectins; Humans; Integrins; Jurkat Cells; Leukocytes; Lovastatin; Methionine; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Tetradecanoylphorbol Acetate; U937 Cells	1999
Effect of perillic acid, a putative isoprenylation inhibitor, on the cultured rat lens. Experimental eye research, 2001, Volume: 73, Issue:2 Topics: Animals; Antineoplastic Agents, Phytogenic; Cataract; Cyclohexenes; Diterpenes; Dose-Response Relationship, Drug; Farnesol; Female; GTP Phosphohydrolases; Lens, Crystalline; Lovastatin; Male; Monoterpenes; Organ Culture Techniques; Protein Prenylation; Rats; Rats, Sprague-Dawley; Terpenes	2001
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. The Journal of biological chemistry, 2002, May-03, Volume: 277, Issue:18 Topics: Apoptosis; Benzamides; Caspase 3; Caspases; Cell Death; Cells, Cultured; Diterpenes; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Lovastatin; Methionine; Polyisoprenyl Phosphates; Protein Prenylation; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein; Umbilical Veins	2002
Farnesol and geranylgeraniol: prevention and reversion of lovastatin-induced effects in NIH3T3 cells. Lipids, 2002, Volume: 37, Issue:2 Topics: 3T3 Cells; Animals; Anticholesteremic Agents; Diterpenes; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Protein Prenylation	2002
Lack of isoprenoid products raises ex vivo interleukin-1beta secretion in hyperimmunoglobulinemia D and periodic fever syndrome. Arthritis and rheumatism, 2002, Volume: 46, Issue:10 Topics: Antibodies; CD2 Antigens; CD28 Antigens; Cell Division; Cells, Cultured; Child; Diterpenes; Familial Mediterranean Fever; Farnesol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypergammaglobulinemia; Immunoglobulin D; Interleukin-1; Lovastatin; Male; Mevalonic Acid; Phosphotransferases (Alcohol Group Acceptor); Polyisoprenyl Phosphates; T-Lymphocytes	2002
Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels. Blood, 2003, Nov-01, Volume: 102, Issue:9 Topics: Alkyl and Aryl Transferases; Apoptosis; Bone Marrow Cells; Cell Line, Tumor; Diterpenes; Down-Regulation; Drug Antagonism; Enzyme Inhibitors; Humans; Lovastatin; Mitochondria; Mitochondrial Proteins; Multiple Myeloma; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Protein Prenylation; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured	2003
Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology, 2003, Volume: 144, Issue:9 Topics: Anticholesteremic Agents; Apoptosis; Caspases; Cell Membrane; Cell Survival; Cytochrome c Group; Cytosol; Diterpenes; Humans; Intracellular Signaling Peptides and Proteins; Lovastatin; Protein Prenylation; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Thyroid Neoplasms; Tumor Cells, Cultured	2003
Isoprenoid alcohols restore protein isoprenylation in a time-dependent manner independent of protein synthesis. Lipids, 2003, Volume: 38, Issue:7 Topics: Alcohols; Animals; Cycloheximide; Diterpenes; Farnesol; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lovastatin; Mice; Monomeric GTP-Binding Proteins; NIH 3T3 Cells; Protein Biosynthesis; Protein Prenylation; Protein Synthesis Inhibitors; ras Proteins; Terpenes	2003
Statins upregulate CD36 expression in human monocytes, an effect strengthened when combined with PPAR-gamma ligands Putative contribution of Rho GTPases in statin-induced CD36 expression. Biochemical pharmacology, 2004, Jan-15, Volume: 67, Issue:2 Topics: Actins; Anticholesteremic Agents; CD36 Antigens; Cells, Cultured; Cytoskeleton; Diterpenes; Farnesol; Gene Expression Regulation; Humans; Lipoproteins, LDL; Lovastatin; Mevalonic Acid; Monocytes; Receptors, Cytoplasmic and Nuclear; rho GTP-Binding Proteins; RNA, Messenger; Transcription Factors; Transcription, Genetic	2004
Lipid metabolism in zebrafish. Methods in cell biology, 2004, Volume: 76 Topics: 4-Chloro-7-nitrobenzofurazan; Alkyl and Aryl Transferases; Animals; Annexin A2; Atorvastatin; Azetidines; Boron Compounds; Caveolin 1; Caveolins; Cell Movement; Cholesterol; Diterpenes; DNA; Embryo, Nonmammalian; Ethylnitrosourea; Ezetimibe; Farnesol; Farnesyltranstransferase; Geranyltranstransferase; Germ Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipid Metabolism; Lipids; Lovastatin; Mevalonic Acid; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Phosphatidylethanolamines; Protein Binding; Protein Prenylation; Pyrroles; Simvastatin; Zebrafish	2004
Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation. Molecular and cellular neurosciences, 2005, Volume: 29, Issue:4 Topics: Animals; Cell Differentiation; Cholesterol; Diterpenes; Enzyme Activation; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Lovastatin; Neurites; PC12 Cells; Phosphorylation; Protein Prenylation; Protein Serine-Threonine Kinases; Rats; rho-Associated Kinases; rhoA GTP-Binding Protein; Sterols; Terpenes	2005
The level of ATP analog and isopentenyl pyrophosphate correlates with zoledronic acid-induced apoptosis in cancer cells in vitro. Bone, 2009, Volume: 45, Issue:6 Topics: Adenosine Triphosphate; Apoptosis; Cell Line, Tumor; Diphosphonates; Diterpenes; Drug Resistance, Neoplasm; Hemiterpenes; Humans; Imidazoles; Lovastatin; Membrane Potential, Mitochondrial; Neoplasms; Organophosphorus Compounds; Zoledronic Acid	2009
Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis. British journal of pharmacology, 2009, Volume: 158, Issue:7 Topics: Cell Death; Cell Line, Tumor; Cell Proliferation; Cholesterol; Diterpenes; Electron Transport; Hep G2 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mitochondria; Monocytes; Terpenes; Ubiquinone	2009
Mevalonate depletion mediates the suppressive impact of geranylgeraniol on murine B16 melanoma cells. Experimental biology and medicine (Maywood, N.J.), 2011, May-01, Volume: 236, Issue:5 Topics: 3T3-L1 Cells; Alkaline Phosphatase; Animals; Apoptosis; Cell Cycle; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Diterpenes; Humans; Lovastatin; Melanoma, Experimental; Mevalonic Acid; Mice; Vitamin E	2011
Inhibition of neuronal cholesterol biosynthesis with lovastatin leads to impaired synaptic vesicle release even in the presence of lipoproteins or geranylgeraniol. Journal of neurochemistry, 2011, Volume: 119, Issue:5 Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Astrocytes; Cell Line; Cholesterol; Diterpenes; Lipoproteins; Lovastatin; Mice; Neural Inhibition; Neurons; Presynaptic Terminals; Primary Cell Culture; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Synaptic Vesicles	2011
Lovastatin-induced apoptosis is modulated by geranylgeraniol in a neuroblastoma cell line. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2012, Volume: 30, Issue:6 Topics: Analysis of Variance; Apoptosis; Caspases; Cell Line, Tumor; Diterpenes; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Neuroblastoma; Time Factors	2012
Inhibiting geranylgeranylation increases neurite branching and differentially activates cofilin in cell bodies and growth cones. Molecular neurobiology, 2014, Volume: 50, Issue:1 Topics: Animals; Cell Body; Cell Line, Tumor; Cell Shape; Cofilin 1; Diterpenes; Growth Cones; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Neurites; Protein Prenylation; Rats	2014