Compounds > geraniin
Page last updated: 2024-09-03

geraniin and glucose, (beta-d)-isomer

geraniin has been researched along with glucose, (beta-d)-isomer in 86 studies

Compound Research Comparison

Studies
(geraniin)		Trials
(geraniin)		Recent Studies (post-2010)
(geraniin)		Studies
(glucose, (beta-d)-isomer)		Trials
(glucose, (beta-d)-isomer)		Recent Studies (post-2010) (glucose, (beta-d)-isomer)
9416621,95688310,747

Research

Studies (86)

TimeframeStudies, this research(%)All Research%
pre-19905 (5.81)18.7374
1990's6 (6.98)18.2507
2000's13 (15.12)29.6817
2010's48 (55.81)24.3611
2020's14 (16.28)2.80

Authors

AuthorsStudies
Ishino, M; Mori, K; Okuda, T1
Hatano, T; Higuchi, K; Mori, K; Okuda, T; Terayama, K1
Abe, H; Fang, T; Okuda, T; Ushio, Y1
Abe, H; Okuda, T; Ushio, Y1
Arichi, S; Kimura, Y; Okuda, H; Okuda, T1
Fukaya, Y; Iwata, S; Nakazawa, K; Okuda, T1
Arichi, S; Kimura, Y; Mori, K; Okuda, H; Okuda, T1
Chang, SS; Cheng, JT; Hsu, FL1
Foo, Y; Hopkirk, N; Lucas, CR; Milne, A; Waldon, J1
Calixto, JB; Cechinel Filho, V; Ferrari, F; Messana, I; Miguel, OG; Pizzolatti, MG; Santos, AR; Yunes, RA1
Cheng, JT; Hung, CR; Neu, SL1
Ho, CT; Lin, JH; Lin, JK; Lin-Shiau, SY; Pan, MH1
Adesina, SK; Idowu, O; Ogundaini, AO; Oladimeji, H; Olugbade, TA; Onawunmi, GO; Pais, M1
Fujiki, H; Imayoshi, Y; Okabe, S; Suganuma, M; Taniguchi, S; Yoshida, T1
Hatano, T; Ito, H; Kato, R; Taniguchi, S; Uechi, K; Yazaki, K; Yoshida, T1
Meier, GR; Notka, F; Wagner, R1
Chang, C; Chen, CC; Hsu, FL; Huang, RL; Huang, YL; Ou, JC1
Lee, SH; Nishioka, I; Nonaka, G; Tanaka, T1
Cheng, HY; Chiang, LC; Lin, CC; Lin, TC; Yang, CM1
Cho, SW; Hahm, KB; Han, SU; Lee, KM; Park, KH; Park, S1
Hatano, T; Iguchi, A; Ito, H1
Feng, M; Huang, H; Li, J; Zhou, P; Zhou, W1
Chang, CS; Huang, LJ; Kao, JY; Kao, MC; Kuo, SC; Lee, JC; Lin, JK; Tsai, CY; Tsai, SC; Way, TD1
Hou, WC; Lin, SY; Lu, YL; Wang, CC; Wu, WC1
Hyun, JW; Kang, KA; Kim, BJ; Kim, KC; Kim, SY; Lee, IK; Lee, NH; Piao, MJ; Shin, T; Zhang, R1
Agyare, C; Deters, A; Hensel, A; Lechtenberg, M; Petereit, F1
Ito, H1
Hatano, T; Ishimoto, H; Ito, H; Myojin, Y; Shibata, M; Sugimoto, Y; Tai, A1
Guan, Y; Jin, X; Liu, LF; Wu, QY; Xu, M; Zhou, Y1
Fan, X; Liu, J; Qin, C; Yang, Y; Zhang, L1
Devasagayam, TP; Foo, LY; Ghaskadbi, SS; Londhe, JS; Shastry, P1
Chen, P; He, B; Hu, M; Li, SD; Liu, JX; Lu, YQ; Shen, ZQ; Yang, XT1
Ahn, G; Bing, SJ; Ha, D; Jee, Y; Kim, DS; Kim, MJ; Ko, RK; Lee, NH; Park, E; Park, JW1
Mutikainen, P; Salminen, JP; Toivonen, E; Tuominen, A1
Jun, M; Youn, K2
Jaganath, IB; Lee, SH; Manikam, R; Ong, KC; Payne, BJ; Rathkrishnan, A; Sekaran, SD; Tang, YQ; Wang, SM1
Dal Piaz, F; De Tommasi, N; Leone, A; Vaccaro, MC; Vassallo, A1
Li, J; Pan, L; Wang, S; Yin, J1
Fan, Q; Gu, D; Jiang, C; Li, H; Liu, X; Ouyang, Z; Qin, A; Qu, X; Tang, T; Xiao, F; Zhai, Z1
Anokwuru, CP; Samie, A; Sinisi, A; Taglialatela-Scafati, O1
Altamirano-Báez, DA; Ángeles, LJ; Bautista-Ávila, M; Cariño-Cortés, R; De la O Arciniega, M; Gayosso de Lucio, JA; Ortiz, MI; Velázquez-González, C1
Chen, P; He, B; Li, S; Lu, Y; Shen, Z; Song, B; Yan, H; Yang, R; Yun, Y; Zhang, X; Zhang, Y1
Elendran, S; Palanisamy, UD; Prankerd, R; Wang, LW1
Fu, YJ; Ma, WD; Peng, X; Wang, P; Wang, W; Wei, FY; Wei, ZF; Yao, LP; Zu, YG1
Ko, H1
Chen, J; He, P; Jiang, L; Liu, S; Liu, Y; Tan, N1
Fu, YJ; Gao, C; Luo, M; Ma, WD; Wang, W; Xia, XX; Yao, LP; Zhai, JW; Zu, YG1
Abotsi, WK; Agyare, C; Ayande, PG; Boakye, YD; Ossei, PP1
Byun, HS; Hur, GM; Kang, K; Kim, HG; Lee, IY; Lee, SR; Lee, Y; Park, KA; Seo, W; Seok, JH; Shen, HM; Sohn, KC; Son, CG; Won, M1
Fu, YJ; Li, J; Qiao, Q; Wang, P; Wang, W; Yao, LP1
Li, J; Liu, X; Lv, B; Peng, X; Wang, P; Yu, B; Zhao, X1
Cai, D; Chen, X; Guo, H; Liu, C; Tang, W; Yan, R; Zhang, L1
Barros, L; Calhelha, RC; Carvalho, AM; Dias, MI; Ferreira, IC; Graça, VC; Santos, PF; Santos-Buelga, C1
Huang, Y; Li, K; Liu, Y; Wu, C; Xin, X; Zhu, G1
Chen, Z; Jiang, ZK; Li, X; Ping, FF; Wang, X; Zhao, YQ1
Aayadi, H; Deshpande, A; Ghaskadbi, SS; Gore, M; Mittal, SPK1
Ahn, G; Bing, SJ; Cho, J; Herath, KHINM; Jee, Y; Kim, A; Lee, NH; Park, JW1
Chai, Y; Lu, S; Wan, D; Wang, Y; Zhong, W; Zhou, R1
Abotsi, WKM; Agyare, C; Ameyaw, EO; Biney, RP; Boakye-Gyasi, E; Kasanga, EA; Woode, E1
Almaguer, G; Bobadilla, NA; Cruz, C; Gamba, G; Gayosso, JA; Mercado, A; Montejano, JR; Moreno, E; Ramírez, V; Sierra, A; Vázquez, N1
Abdul Ahmad, SA; Chew, MF; Palanisamy, UD; Syed Hassan, S; Tejo, BA; Tham, HW1
Huang, D; Liu, X; Lv, B; Wang, X; Xie, Z; Yin, L; Yu, B; Zhang, Y1
Chen, P; Du, W; He, B; Li, K; Shen, Z; Yang, R; Zhang, X; Zhang, Y1
Hirokane, T; Ikeuchi, K; Matsumoto, S; Wakamori, S; Yamada, H1
Guo, X; Liang, Z; Ni, J; Wang, H; Wang, X; Wu, X; Xue, J1
Chen, P; He, B; Li, F; Mo, J; Shen, Z; Yang, R; Zhang, X; Zhao, Y1
Dai, X; Guo, X; Ma, X; Ni, J; Wang, X; Xue, J1
El Kalamouni, C; Grauzdytė, D; Pukalskas, A; Venskutonis, PR; Viranaicken, W1
El Kalamouni, C; Grauzdytė, D; Pukalskas, A; Venskutonis, PR1
Elendran, S; Lee, WW; Muniyandy, S; Palanisamy, UD1
Kadir, KA; Palanisamy, UD; Phang, SCW1
Abdul Ahmad, SA; Dhanoa, A; Khoo, JJ; Palanisamy, UD; Syed Hassan, S1
Chen, MK; Chuang, YT; Hsieh, MJ; Liang, MY; Lin, CW; Su, SC; Yang, JS; Yang, SF; Yeh, CM1
Era, M; Matsuo, Y; Saito, Y; Tanaka, T1
Moorthy, M; Palanisamy, UD; Perera, A; Ton, SH1
Liu, TB; Lü, HN; Zhou, LA1
Desprès, P; Diotel, N; El Kalamouni, C; Grauzdytė, D; Haddad, JG; Koishi, AC; Nunes Duarte Dos Santos, C; Venskutonis, PR; Viranaicken, W1
Ahemad, N; Goh, BH; Khan, SU; Looi, D; Palanisamy, UD1
Cui, X; Gao, F; Guo, S; Li, Z; Ma, M; Wang, M; Wang, X; Wang, Z1
Lei, J; Wei, Y; Zhang, H; Zhou, R1
Choi, JG; Chung, HS; Chung, HY; Kim, YS; Lee, B; Noh, SG1
Chen, S; Deng, B; Deng, F; Dong, F; Huang, Y; Jia, H; Li, J; Li, Z; Liao, Z; Lin, J; Lin, Z; Lv, X; Ma, P; Ma, X; Ma, Y; Matsumoto, T; Ming, R; Xia, R; Xu, X; Yang, Z; Zhang, J; Zhang, S; Zhang, W; Zhang, X; Zheng, S1
Alfhili, MA; Alshaiddi, W; Alshammary, A; Alsubki, R; Alsughayyir, J; Basudan, AM1
Chen, L; Chen, P; He, B; Li, R; Shen, Z; Xia, X; Yang, R; Yang, Y; Zhang, X1
Feng, Y; Li, H; Li, J; Lin, K; Liu, X; Tian, J; Wang, X; Xi, X; Yin, L; Yu, B; Zhao, P1

Reviews

2 review(s) available for geraniin and glucose, (beta-d)-isomer

ArticleYear
Metabolites of the ellagitannin geraniin and their antioxidant activities.
    Planta medica, 2011, Volume: 77, Issue:11

    Topics: Animals; Antioxidants; Biphenyl Compounds; Chromatography, High Pressure Liquid; Coumarins; Free Radical Scavengers; Geranium; Glucosides; Hydrolyzable Tannins; Intestinal Mucosa; Intestines; Magnetic Resonance Spectroscopy; Metabolic Networks and Pathways; Picrates; Pyrones; Rats

2011
Structural Revisions in Natural Ellagitannins.
    Molecules (Basel, Switzerland), 2018, Jul-30, Volume: 23, Issue:8

    Topics: Benzopyrans; Glucosides; Hydrolyzable Tannins; Molecular Structure; Oxidation-Reduction; Phenols; Terminology as Topic

2018

Trials

1 trial(s) available for geraniin and glucose, (beta-d)-isomer

ArticleYear
Failure of New Zealand hepatitis B carriers to respond to Phyllanthus amarus.
    The New Zealand medical journal, 1994, Jun-22, Volume: 107, Issue:980

    Topics: Adolescent; Adult; Aged; Carrier State; Glucosides; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Humans; Hydrolyzable Tannins; Male; Middle Aged; Plant Extracts; Plants, Medicinal; Tannins

1994

Other Studies

83 other study(ies) available for geraniin and glucose, (beta-d)-isomer

ArticleYear
[Constituents of Geranium thunbergii Sieg. et Zucc. VIII. Transformations of geraniin upon decoction (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1979, Volume: 99, Issue:5

    Topics: Chemical Phenomena; Chemistry, Physical; Glucosides; Glycosides; Hydrolysis; Hydrolyzable Tannins; Plants, Medicinal; Tannins

1979
[Isolation of geraniin from plants of Geranium and Euphorbiaceae (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1979, Volume: 99, Issue:5

    Topics: Glucosides; Glycosides; Hydrolyzable Tannins; Plants, Medicinal; Tannins

1979
Modificational changes in function and morphology of cultured macrophages by geraniin.
    Japanese journal of pharmacology, 1991, Volume: 57, Issue:2

    Topics: Acid Phosphatase; Animals; Cell Membrane; Cells, Cultured; Cytoplasm; Glucosides; Hydrolyzable Tannins; Macrophages; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron; Peritoneal Cavity; Phagocytosis; Ruthenium Red; Saccharomyces cerevisiae; Tannins

1991
Effects of geraniin on morphology and function of macrophages.
    International archives of allergy and applied immunology, 1991, Volume: 96, Issue:3

    Topics: Actin Cytoskeleton; Animals; Cell Adhesion; Cell Membrane; Endocytosis; Glucosides; Hydrolyzable Tannins; In Vitro Techniques; Macrophages; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Microtubules; Phagocytosis; Pinocytosis; Tannins

1991
Studies on the activities of tannins and related compounds; VIII. Effects of geraniin, corilagin, and ellagic acid isolated from geranii herba on arachidonate metabolism in leukocytes.
    Planta medica, 1986, Issue:4

    Topics: Arachidonic Acid; Arachidonic Acids; Benzopyrans; Ellagic Acid; Glucosides; Glycosides; Humans; Hydrolyzable Tannins; In Vitro Techniques; Leukocytes; Tannins

1986
Effect of tannin on oxidative damage of ocular lens.
    Japanese journal of ophthalmology, 1988, Volume: 32, Issue:2

    Topics: Animals; Cell-Free System; Diamide; Glucosides; Glycosides; Hydrolyzable Tannins; In Vitro Techniques; Lens, Crystalline; Mice; Oxidation-Reduction; Sulfhydryl Compounds; Tannins; Xanthine; Xanthine Oxidase; Xanthines

1988
Studies on the activities of tannins and related compounds from medicinal plants and drugs. IV. Effects of various extracts of Geranii herba and geraniin on liver injury and lipid metabolism in rats fed peroxidized oil.
    Chemical & pharmaceutical bulletin, 1984, Volume: 32, Issue:5

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Glucosides; Glycosides; Hydrolyzable Tannins; Lipid Peroxides; Male; Oils; Plant Extracts; Rats; Rats, Inbred Strains; Tannins; Zea mays

1984
Antihypertensive action of geraniin in rats.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:1

    Topics: Adrenalectomy; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Glucosides; Hydrolyzable Tannins; Male; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tannins

1994
Chemical and preliminary analgesic evaluation of geraniin and furosin isolated from Phyllanthus sellowianus.
    Planta medica, 1996, Volume: 62, Issue:2

    Topics: Abdominal Pain; Acetaminophen; Acetates; Acetic Acid; Analgesics; Animals; Aspirin; Brazil; Glucosides; Hydrolyzable Tannins; Male; Medicine, Traditional; Mice; Molecular Structure; Plants, Medicinal; Tannins

1996
Prophylactic effects of sucralfate and geraniin on ethanol-induced gastric mucosal damage in rats.
    The Chinese journal of physiology, 1995, Volume: 38, Issue:4

    Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Gastric Mucosa; Glucosides; Hydrolyzable Tannins; Male; Rats; Rats, Sprague-Dawley; Sucralfate; Tannins

1995
Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages.
    Biochemical pharmacology, 2000, Feb-15, Volume: 59, Issue:4

    Topics: Animals; Antioxidants; Biflavonoids; Catechin; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Flavonoids; Gallic Acid; Gene Expression; Glucosides; Hydrolyzable Tannins; I-kappa B Kinase; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phenols; Phosphorylation; Polymers; Polyphenols; Protein Serine-Threonine Kinases; Tannins; Tea

2000
Antimicrobial constituents of the leaves of Acalypha wilkesiana and Aacalypha hispida.
    Phytotherapy research : PTR, 2000, Volume: 14, Issue:5

    Topics: Anti-Bacterial Agents; Euphorbiaceae; Glucosides; Humans; Hydrolyzable Tannins; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Plant Extracts; Plant Leaves; Plants, Medicinal; Tannins

2000
New TNF-alpha releasing inhibitors, geraniin and corilagin, in leaves of Acer nikoense, Megusurino-ki.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:10

    Topics: 3T3 Cells; 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Carcinogens; Chromatography, High Pressure Liquid; Glucosides; Hydrolyzable Tannins; Mice; Mice, Inbred BALB C; Plant Extracts; Plant Leaves; Plants, Medicinal; Skin Neoplasms; Tannins; Tumor Necrosis Factor-alpha

2001
Accumulation of hydrolyzable tannins by Aleurites fordii callus culture.
    Planta medica, 2002, Volume: 68, Issue:12

    Topics: Aleurites; Chromatography, High Pressure Liquid; Culture Techniques; Glucosides; Hydrolyzable Tannins; Light; Molecular Structure; Plant Extracts; Plant Leaves; Tannins

2002
Inhibition of wild-type human immunodeficiency virus and reverse transcriptase inhibitor-resistant variants by Phyllanthus amarus.
    Antiviral research, 2003, Volume: 58, Issue:2

    Topics: CD4 Antigens; Drug Resistance, Viral; Euphorbiaceae; Glucosides; HeLa Cells; HIV-1; HIV-2; Humans; Hydrolyzable Tannins; Plant Extracts; Plants, Medicinal; Reverse Transcriptase Inhibitors; Tannins; Tumor Cells, Cultured; Virus Replication

2003
Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B virus in vitro.
    Phytotherapy research : PTR, 2003, Volume: 17, Issue:5

    Topics: 4-Butyrolactone; Anisoles; Benzodioxoles; Culture Techniques; Dioxoles; Enzyme-Linked Immunosorbent Assay; Glucosides; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Hydrolyzable Tannins; Lignans; Molecular Structure; Phyllanthus; Phytotherapy; Plant Extracts; Tannins

2003
Structure and biogenesis of jolkinin, a highly oxygenated ellagitannin from Euphorbia jolkinii.
    Journal of natural products, 2004, Volume: 67, Issue:6

    Topics: Euphorbia; Glucosides; Hydrolyzable Tannins; Japan; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Tannins

2004
The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against herpes simplex virus type 1 and type 2 infection.
    Journal of ethnopharmacology, 2007, Apr-04, Volume: 110, Issue:3

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Dose-Response Relationship, Drug; Gallic Acid; Glucosides; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; Hydrolyzable Tannins; Kidney; Medicine, East Asian Traditional; Monosaccharides; Phyllanthus; Phytotherapy; Plant Extracts; Plants, Medicinal; Vero Cells

2007
5-LOX inhibitor modulates the inflammatory responses provoked by Helicobacter pylori infection.
    Helicobacter, 2007, Volume: 12, Issue:1

    Topics: Animals; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Cell Line; Down-Regulation; Epithelial Cells; Glucosides; Helicobacter Infections; Helicobacter pylori; Humans; Hydrolyzable Tannins; Interleukin-8; Lipoxygenase Inhibitors; Macrophages; Masoprocol; Mitogen-Activated Protein Kinase 3; NF-kappa B; Oxidation-Reduction; Signal Transduction; Tumor Necrosis Factor-alpha

2007
Identification of urinary and intestinal bacterial metabolites of ellagitannin geraniin in rats.
    Journal of agricultural and food chemistry, 2008, Jan-23, Volume: 56, Issue:2

    Topics: Animals; Antioxidants; Bacteria; Feces; Glucosides; Hydrolyzable Tannins; Intestines; Male; Rats

2008
Anti-hepatitis B virus activities of Geranium carolinianum L. extracts and identification of the active components.
    Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:4

    Topics: Acetates; Antiviral Agents; Cell Line; Cell Survival; Ellagic Acid; Flavonoids; Geranium; Glucosides; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Hydrolyzable Tannins; Magnetic Resonance Spectroscopy; Plant Extracts; Quercetin; Solvents; Spectrophotometry, Ultraviolet

2008
Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells.
    Molecular nutrition & food research, 2008, Volume: 52, Issue:6

    Topics: Anticarcinogenic Agents; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Caspase 8; Caspase Inhibitors; Cell Line, Tumor; Cytochromes c; Enzyme Activation; Enzyme Inhibitors; Fas Ligand Protein; Focal Adhesion Protein-Tyrosine Kinases; Glucosides; Humans; Hydrolyzable Tannins; Melanoma; Up-Regulation

2008
Antioxidant, anti-semicarbazide-sensitive amine oxidase, and anti-hypertensive activities of geraniin isolated from Phyllanthus urinaria.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:7

    Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Glucosides; Hydrolyzable Tannins; Hypertension; Male; Phyllanthus; Phytotherapy; Random Allocation; Rats; Rats, Inbred SHR

2008
Radioprotective effect of geraniin via the inhibition of apoptosis triggered by γ-radiation-induced oxidative stress.
    Cell biology and toxicology, 2011, Volume: 27, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Cell Line; Cell Survival; Cricetinae; DNA Damage; Free Radical Scavengers; Gamma Rays; Glucosides; Hydrolyzable Tannins; Lipid Metabolism; Oxidative Stress; Proteins; Radiation-Protective Agents; Reactive Oxygen Species

2011
Ellagitannins from Phyllanthus muellerianus (Kuntze) Exell.: Geraniin and furosin stimulate cellular activity, differentiation and collagen synthesis of human skin keratinocytes and dermal fibroblasts.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2011, May-15, Volume: 18, Issue:7

    Topics: Cell Differentiation; Chromatography, High Pressure Liquid; Collagen; Fibroblasts; Flavonoids; Glucosides; Humans; Hydrolyzable Tannins; Keratinocytes; Medicine, African Traditional; Phyllanthus; Plant Extracts; Plant Leaves; Plants, Medicinal; Skin; Wound Healing

2011
In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A.
    Bioorganic & medicinal chemistry letters, 2011, Oct-01, Volume: 21, Issue:19

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Discovery; Drug Evaluation, Preclinical; Edema; Free Radical Scavengers; Glucosides; Glucuronides; Humans; Hydrolyzable Tannins; Lythraceae; Mice; Mice, Inbred ICR; Rats

2011
Chromatographic fingerprint and the simultaneous determination of five bioactive components of geranium carolinianum L. water extract by high performance liquid chromatography.
    International journal of molecular sciences, 2011, Volume: 12, Issue:12

    Topics: Chromatography, High Pressure Liquid; Geranium; Glucosides; Hydrolyzable Tannins; Plant Extracts

2011
Antiviral effect of geraniin on human enterovirus 71 in vitro and in vivo.
    Bioorganic & medicinal chemistry letters, 2012, Mar-15, Volume: 22, Issue:6

    Topics: Animals; Antiviral Agents; Cell Line, Tumor; Enterovirus A, Human; Enterovirus Infections; Glucosides; Humans; Hydrolyzable Tannins; Mice; Mice, Inbred ICR; Survival Rate; Viral Load; Virus Replication

2012
Geraniin and amariin, ellagitannins from Phyllanthus amarus, protect liver cells against ethanol induced cytotoxicity.
    Fitoterapia, 2012, Volume: 83, Issue:8

    Topics: Animals; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Ethanol; Gene Expression Regulation; Glucosides; Hepatocytes; Hydrolyzable Tannins; Mice; Oxidation-Reduction; Phyllanthus; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-bcl-2

2012
Effects of geraniin on osteoclastic bone resorption and matrix metalloproteinase-9 expression.
    Bioorganic & medicinal chemistry letters, 2013, Feb-01, Volume: 23, Issue:3

    Topics: Animals; Bone Density Conservation Agents; Bone Resorption; Cell Line; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Glucosides; Hydrolyzable Tannins; Matrix Metalloproteinase 9; Molecular Structure; Osteoclasts; Rats; RNA, Messenger

2013
Geraniin down regulates gamma radiation-induced apoptosis by suppressing DNA damage.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2013, Volume: 57

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Proliferation; Cells, Cultured; DNA Damage; Gamma Rays; Genes, p53; Glucosides; Hydrolyzable Tannins; Injections, Intraperitoneal; Intestine, Small; Jejunum; Mice; Mice, Inbred C57BL; Nymphaea; Proto-Oncogene Proteins c-bcl-2; Radiation-Protective Agents; Radiation, Ionizing; Spleen; Toxicity Tests, Acute; Whole-Body Irradiation

2013
Defensive strategies in Geranium sylvaticum. Part 1: organ-specific distribution of water-soluble tannins, flavonoids and phenolic acids.
    Phytochemistry, 2013, Volume: 95

    Topics: Disease Resistance; Flavonoids; Geranium; Glucosides; Glycosides; Herbivory; Hydrolyzable Tannins; Hydroxybenzoates; Phenols; Plant Diseases; Plant Structures; Polyphenols; Tannins

2013
In vitro BACE1 inhibitory activity of geraniin and corilagin from Geranium thunbergii.
    Planta medica, 2013, Volume: 79, Issue:12

    Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Dose-Response Relationship, Drug; Geranium; Glucosides; Humans; Hydrolyzable Tannins; Plants, Medicinal

2013
Effects of cocktail of four local Malaysian medicinal plants (Phyllanthus spp.) against dengue virus 2.
    BMC complementary and alternative medicine, 2013, Jul-26, Volume: 13

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Dengue; Dengue Virus; Gallic Acid; Glucosides; Humans; Hydrolyzable Tannins; Phenylpropionates; Phyllanthus; Plant Extracts; Plants, Medicinal; Tandem Mass Spectrometry; Vero Cells

2013
Identification of the plant compound geraniin as a novel Hsp90 inhibitor.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Cell Cycle; Glucosides; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Hydrolyzable Tannins; Jurkat Cells

2013
Geraniin induces apoptotic cell death in human lung adenocarcinoma A549 cells in vitro and in vivo.
    Canadian journal of physiology and pharmacology, 2013, Volume: 91, Issue:12

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Caspase 9; Cell Cycle Checkpoints; Cell Death; Cell Line, Tumor; Cell Proliferation; Cytochromes c; Glucosides; Humans; Hydrolyzable Tannins; Lung Neoplasms; Membrane Potential, Mitochondrial; Mice; Mice, Nude; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; S Phase

2013
Geraniin suppresses RANKL-induced osteoclastogenesis in vitro and ameliorates wear particle-induced osteolysis in mouse model.
    Experimental cell research, 2015, Jan-01, Volume: 330, Issue:1

    Topics: Actins; Animals; Glucosides; Hydrolyzable Tannins; Macrophages; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; NF-kappa B; NFATC Transcription Factors; Osteoclasts; Osteogenesis; Osteolysis; Proto-Oncogene Proteins c-fos; RANK Ligand; Skull; Titanium

2015
Antibacterial and antioxidant constituents of Acalypha wilkesiana.
    Natural product research, 2015, Volume: 29, Issue:12

    Topics: Acalypha; Anti-Bacterial Agents; Free Radical Scavengers; Glucosides; Hydrolyzable Tannins; Klebsiella pneumoniae; Microbial Sensitivity Tests; Molecular Structure; Phytosterols; Plant Extracts; Plant Leaves; Shikimic Acid

2015
Antinociceptive and anti-inflammatory activities of Geranium bellum and its isolated compounds.
    BMC complementary and alternative medicine, 2014, Dec-17, Volume: 14

    Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Ellagic Acid; Female; Formaldehyde; Geranium; Glucosides; Hot Temperature; Hydrolyzable Tannins; Inflammation; Male; Mexico; Mice; Pain; Pain Measurement; Phytotherapy; Plant Extracts; Quercetin; Rats, Wistar

2014
Osteoprotective effect of geraniin against ovariectomy-induced bone loss in rats.
    Bioorganic & medicinal chemistry letters, 2015, Feb-01, Volume: 25, Issue:3

    Topics: Alkaline Phosphatase; Animals; Bone Density; Calcitonin; Calcium; Disease Models, Animal; Estradiol; Female; Femur; Glucosides; Hydrolyzable Tannins; Osteoporosis; Ovariectomy; Rats; Rats, Wistar

2015
The physicochemical properties of geraniin, a potential antihyperglycemic agent.
    Pharmaceutical biology, 2015, Volume: 53, Issue:12

    Topics: Chemical Phenomena; Crystallization; Glucosides; Hydrolyzable Tannins; Hypoglycemic Agents; Plant Extracts; Sapindaceae

2015
Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway.
    Biochimica et biophysica acta, 2015, Volume: 1850, Issue:9

    Topics: Active Transport, Cell Nucleus; Antioxidants; Cell Proliferation; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Glucosides; Hep G2 Cells; Humans; Hydrolyzable Tannins; MAP Kinase Signaling System; Mitochondrial Membranes; NF-E2-Related Factor 2; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Up-Regulation

2015
Geraniin inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer migration, invasion and anoikis resistance.
    Bioorganic & medicinal chemistry letters, 2015, Sep-01, Volume: 25, Issue:17

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Anoikis; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Movement; Epithelial-Mesenchymal Transition; Glucosides; Humans; Hydrolyzable Tannins; Lung; Lung Neoplasms; Neoplasm Invasiveness; Phyllanthus; Transforming Growth Factor beta1

2015
Geraniin ameliorates cisplatin-induced nephrotoxicity in mice.
    Free radical research, 2016, Volume: 50, Issue:8

    Topics: Animals; Cisplatin; Disease Models, Animal; Glucosides; Hydrolyzable Tannins; Kidney; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Renal Insufficiency

2016
Geraniin induces apoptosis of human breast cancer cells MCF-7 via ROS-mediated stimulation of p38 MAPK.
    Toxicology mechanisms and methods, 2016, Volume: 26, Issue:5

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Culture Techniques; Cell Cycle; Cell Survival; Dose-Response Relationship, Drug; Flow Cytometry; Glucosides; Humans; Hydrolyzable Tannins; MCF-7 Cells; Membrane Potential, Mitochondrial; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; Time Factors

2016
Anti-inflammatory activity of aqueous leaf extract of Phyllanthus muellerianus (Kuntze) Exell. and its major constituent, geraniin.
    Journal of ethnopharmacology, 2016, Jul-01, Volume: 187

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Edema; Freund's Adjuvant; Glucosides; Hindlimb; Hydrolyzable Tannins; Male; Phyllanthus; Phytotherapy; Plant Extracts; Plant Leaves; Rats, Sprague-Dawley

2016
Terminalia Chebula provides protection against dual modes of necroptotic and apoptotic cell death upon death receptor ligation.
    Scientific reports, 2016, 04-27, Volume: 6

    Topics: Cell Death; Glucosides; Hydrolyzable Tannins; Plant Extracts; Reactive Oxygen Species; Receptors, Death Domain; Terminalia; Tumor Necrosis Factor-alpha

2016
Inhibitory effects of geraniin on LPS-induced inflammation via regulating NF-κB and Nrf2 pathways in RAW 264.7 cells.
    Chemico-biological interactions, 2016, Jun-25, Volume: 253

    Topics: Animals; Blotting, Western; Cell Survival; Cytokines; Glucosides; Heme Oxygenase-1; Hydrolyzable Tannins; Inflammation; Lipopolysaccharides; Mice; NF-E2-Related Factor 2; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Phosphorylation; RAW 264.7 Cells; Signal Transduction; Up-Regulation

2016
Geraniin Inhibits LPS-Induced THP-1 Macrophages Switching to M1 Phenotype via SOCS1/NF-κB Pathway.
    Inflammation, 2016, Volume: 39, Issue:4

    Topics: Cell Line; Cytokines; Gene Expression Regulation; Glucosides; Humans; Hydrolyzable Tannins; Lipopolysaccharides; Macrophages; NF-kappa B; Phenotype; RNA, Messenger; Suppressor of Cytokine Signaling 1 Protein; Transcription Factor RelA

2016
Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA.
    Antiviral research, 2016, Volume: 134

    Topics: Antiviral Agents; DNA Replication; DNA, Circular; DNA, Viral; Drug Discovery; Drugs, Chinese Herbal; Glucosides; Hepatitis B; Hepatitis B e Antigens; Hepatitis B virus; Hydrolyzable Tannins; Small Molecule Libraries; Virus Replication

2016
Chemical characterization and bioactive properties of aqueous and organic extracts of Geranium robertianum L.
    Food & function, 2016, Sep-14, Volume: 7, Issue:9

    Topics: Acetone; Antineoplastic Agents, Phytogenic; Antioxidants; Cell Line, Tumor; Flavonoids; Geranium; Glucosides; Humans; Hydrolyzable Tannins; Nutritive Value; Phenols; Phytotherapy; Plant Extracts; Portugal; Water

2016
Geraniin attenuates LPS-induced acute lung injury via inhibiting NF-κB and activating Nrf2 signaling pathways.
    Oncotarget, 2017, Apr-04, Volume: 8, Issue:14

    Topics: Acute Lung Injury; Animals; Glucosides; Hydrolyzable Tannins; Inflammation; Lipopolysaccharides; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; NF-kappa B; Random Allocation; Signal Transduction

2017
Geraniin suppresses ovarian cancer growth through inhibition of NF-κB activation and downregulation of Mcl-1 expression.
    Journal of biochemical and molecular toxicology, 2017, Volume: 31, Issue:9

    Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Female; Glucosides; Humans; Hydrolyzable Tannins; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Myeloid Cell Leukemia Sequence 1 Protein; Ovarian Neoplasms; Transcription Factor RelA; Xenograft Model Antitumor Assays

2017
Cytoprotective effect exerted by geraniin in HepG2 cells is through microRNA mediated regulation of BACH-1 and HO-1.
    BMB reports, 2017, Volume: 50, Issue:11

    Topics: Antioxidants; Basic-Leucine Zipper Transcription Factors; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Glucosides; Glycogen Synthase Kinase 3 beta; Heme Oxygenase-1; Hep G2 Cells; Humans; Hydrolyzable Tannins; MAP Kinase Signaling System; Medicine, Chinese Traditional; MicroRNAs; Mitogen-Activated Protein Kinase 3; NF-E2-Related Factor 2; Oxidative Stress; Signal Transduction; Up-Regulation

2017
Geraniin Promotes Recovery of Hematopoietic Cells after Radiation Injury.
    The American journal of Chinese medicine, 2017, Volume: 45, Issue:5

    Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Gamma Rays; Glucosides; Hematopoietic Stem Cells; Hydrolyzable Tannins; Injections, Intraperitoneal; Mice, Inbred C57BL; Nymphaea; Phytotherapy; Radiation Injuries, Experimental; Radiation-Protective Agents; Spleen

2017
Geraniin inhibits migration and invasion of human osteosarcoma cancer cells through regulation of PI3K/Akt and ERK1/2 signaling pathways.
    Anti-cancer drugs, 2017, Volume: 28, Issue:9

    Topics: Bone Neoplasms; Cell Line, Tumor; Cell Movement; Dose-Response Relationship, Drug; Glucosides; Humans; Hydrolyzable Tannins; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Metastasis; Osteosarcoma; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-jun; Transforming Growth Factor beta1

2017
An isobolographic analysis of the anti-nociceptive effect of geraniin in combination with morphine or diclofenac.
    Journal of basic and clinical physiology and pharmacology, 2018, Mar-28, Volume: 29, Issue:2

    Topics: Analgesics, Opioid; Animals; Diclofenac; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Glucosides; Hydrolyzable Tannins; Mice; Mice, Inbred ICR; Morphine; Pain Measurement; Phyllanthus; Plant Extracts

2018
Geraniin is a diuretic by inhibiting the Na
    American journal of physiology. Renal physiology, 2018, 02-01, Volume: 314, Issue:2

    Topics: Animals; Biomarkers; Calcium; Diuresis; Diuretics; Dose-Response Relationship, Drug; Furosemide; Glucosides; HSP90 Heat-Shock Proteins; Hydrolyzable Tannins; Kidney; Male; Natriuresis; Rats, Wistar; Solute Carrier Family 12, Member 1; Time Factors; Xenopus laevis

2018
Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication.
    Virology journal, 2017, 11-21, Volume: 14, Issue:1

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Chromatography, Reverse-Phase; Dengue; Dengue Virus; Dose-Response Relationship, Drug; Glucosides; Humans; Hydrolyzable Tannins; Molecular Docking Simulation; Protein Binding; Sapindaceae; Vero Cells; Viral Envelope Proteins; Viral Plaque Assay; Virus Attachment; Virus Replication

2017
Geraniin protects bone marrow‑derived mesenchymal stem cells against hydrogen peroxide‑induced cellular oxidative stress in vitro.
    International journal of molecular medicine, 2018, Volume: 41, Issue:2

    Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Bone Marrow Cells; Chromones; Gene Expression Regulation; Glucosides; Hydrogen Peroxide; Hydrolyzable Tannins; Membrane Potential, Mitochondrial; Mesenchymal Stem Cells; Morpholines; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats; Reactive Oxygen Species; Signal Transduction

2018
Geraniin promotes osteoblast proliferation and differentiation via the activation of Wnt/β-catenin pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 99

    Topics: Animals; Cell Differentiation; Cell Proliferation; Female; Gene Expression Regulation; Glucosides; Hydrolyzable Tannins; Models, Biological; Osteoblasts; Osteogenesis; Rats, Sprague-Dawley; RNA, Messenger; Wnt Signaling Pathway

2018
Geraniin selectively promotes cytostasis and apoptosis in human colorectal cancer cells by inducing catastrophic chromosomal instability.
    Mutagenesis, 2018, 10-11, Volume: 33, Issue:4

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromosomal Instability; Colorectal Neoplasms; Female; Glucosides; Humans; Hydrolyzable Tannins; Middle Aged

2018
Geraniin promotes osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) via activating β-catenin: a comparative study between BMSCs from normal and osteoporotic rats.
    Journal of natural medicines, 2019, Volume: 73, Issue:1

    Topics: Animals; beta Catenin; Cell Differentiation; Cell Proliferation; Female; Glucosides; Hydrolyzable Tannins; Mesenchymal Stem Cells; Osteogenesis; Osteoporosis; Rats

2019
Geraniin Differentially Modulates Chromosome Stability of Colon Cancer and Noncancerous Cells by Oppositely Regulating their Spindle Assembly Checkpoint.
    Environmental and molecular mutagenesis, 2019, Volume: 60, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromosomal Instability; Colonic Neoplasms; Glucosides; HCT116 Cells; Humans; Hydrolyzable Tannins; M Phase Cell Cycle Checkpoints; Phyllanthus emblica; Spindle Apparatus

2019
Protective effects of Phyllanthus phillyreifolius extracts against hydrogen peroxide induced oxidative stress in HEK293 cells.
    PloS one, 2018, Volume: 13, Issue:11

    Topics: Cell Survival; Gene Expression Regulation; Glucosides; HEK293 Cells; Humans; Hydrogen Peroxide; Hydrolyzable Tannins; Medicine, Traditional; Oxidative Stress; Phyllanthus; Plant Components, Aerial; Plant Extracts; Reactive Oxygen Species

2018
Antioxidant potential and phytochemical composition of extracts obtained from
    Natural product research, 2020, Volume: 34, Issue:5

    Topics: Antioxidants; Chromatography, High Pressure Liquid; Glucosides; Hydrolyzable Tannins; Phyllanthus; Phytochemicals; Plant Extracts; Solvents; Tandem Mass Spectrometry; Tocopherols

2020
Permeability of the ellagitannin geraniin and its metabolites in a human colon adenocarcinoma Caco-2 cell culture model.
    Food & function, 2019, Feb-20, Volume: 10, Issue:2

    Topics: Adenocarcinoma; Biological Transport; Caco-2 Cells; Cell Survival; Colonic Neoplasms; Ellagic Acid; Gallic Acid; Glucosides; Humans; Hydrolyzable Tannins; Molecular Structure; Permeability

2019
Effects of geraniin (rambutan rind extract) on blood pressure and metabolic parameters in rats fed high-fat diet.
    Journal of integrative medicine, 2019, Volume: 17, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Diet, High-Fat; Glucosides; Glycated Hemoglobin; Humans; Hydrolyzable Tannins; Hypertension; Insulin; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Sapindaceae

2019
Efficacy of geraniin on dengue virus type-2 infected BALB/c mice.
    Virology journal, 2019, 02-27, Volume: 16, Issue:1

    Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Dengue; Dengue Virus; Fruit; Glucosides; Hydrolyzable Tannins; Liver; Male; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction; RNA, Viral; Sapindaceae; Vero Cells; Viral Load; Virus Replication

2019
Geraniin inhibits oral cancer cell migration by suppressing matrix metalloproteinase-2 activation through the FAK/Src and ERK pathways.
    Environmental toxicology, 2019, Volume: 34, Issue:10

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Movement; Drugs, Chinese Herbal; Focal Adhesion Protein-Tyrosine Kinases; Geranium; Glucosides; Humans; Hydrolyzable Tannins; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mouth Neoplasms; src-Family Kinases

2019
Production of Ellagitannin Hexahydroxydiphenoyl Ester by Spontaneous Reduction of Dehydrohexa-hydroxydiphenoyl Ester.
    Molecules (Basel, Switzerland), 2020, Feb-26, Volume: 25, Issue:5

    Topics: Betulaceae; Chromatography, High Pressure Liquid; Esters; Euphorbiaceae; Glucosides; Hydrolyzable Tannins; Magnetic Resonance Spectroscopy; Oxidation-Reduction; Plant Extracts; Plant Leaves

2020
The insulin-sensitising properties of the ellagitannin geraniin and its metabolites from
    International journal of food sciences and nutrition, 2020, Volume: 71, Issue:8

    Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Biological Transport; Cell Differentiation; Diabetes Mellitus, Type 2; Fatty Acids, Nonesterified; Glucose; Glucosides; Hydrolyzable Tannins; Hyperglycemia; Insulin; Lipolysis; Mice; Obesity; Plant Extracts; Sapindaceae

2020
Geraniin inhibits proliferation and induces apoptosis through inhibition of phosphatidylinositol 3-kinase/Akt pathway in human colorectal cancer in vitro and in vivo.
    Anti-cancer drugs, 2020, Volume: 31, Issue:6

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; Gene Expression Regulation, Neoplastic; Glucosides; Humans; Hydrolyzable Tannins; In Vitro Techniques; Mice; Mice, Nude; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2020
The Geraniin-Rich Extract from Reunion Island Endemic Medicinal Plant
    Molecules (Basel, Switzerland), 2020, May-15, Volume: 25, Issue:10

    Topics: A549 Cells; Animals; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; Dengue Virus; Glucosides; Hepatocytes; Humans; Hydrolyzable Tannins; Phyllanthus; Phytochemicals; Plant Extracts; Plants, Medicinal; Reunion; Vero Cells; Virus Internalization; Zebrafish; Zika Virus

2020
Geraniin Protects PC12 Cells Against Aβ
    Journal of medicinal food, 2020, Volume: 23, Issue:9

    Topics: Amyloid beta-Peptides; Animals; Apoptosis; Cell Cycle; Glucosides; Hydrolyzable Tannins; MAP Kinase Signaling System; Neuroprotective Agents; NF-kappa B; Oxidative Stress; PC12 Cells; Peptide Fragments; Rats

2020
Metabolites of the ellagitannin, geraniin inhibit human ACE;
    International journal of food sciences and nutrition, 2021, Volume: 72, Issue:4

    Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Carboxypeptidases; Computer Simulation; Coumarins; Ellagic Acid; Glucosides; Humans; Hydrolyzable Tannins; Hypertension; Molecular Docking Simulation; Peptidyl-Dipeptidase A; Polyphenols; Rabbits

2021
Antiosteoporosis effect of geraniin on ovariectomy-induced osteoporosis in experimental rats.
    Journal of biochemical and molecular toxicology, 2021, Volume: 35, Issue:6

    Topics: Animals; Female; Glucosides; Hydrolyzable Tannins; Osteoporosis; Ovariectomy; Rats

2021
Chemoprotective Effects of Geraniin against Azoxymethane Induced Colorectal Cancer by Reduction of Inflammatory Reaction.
    Journal of oleo science, 2021, Volume: 70, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Azoxymethane; Body Weight; Colorectal Neoplasms; Cytokines; Enzymes; Female; Glucosides; Hydrolyzable Tannins; Inflammation; Male; Oxidative Stress; Rats, Wistar

2021
Geraniin Inhibits the Entry of SARS-CoV-2 by Blocking the Interaction between Spike Protein RBD and Human ACE2 Receptor.
    International journal of molecular sciences, 2021, Aug-10, Volume: 22, Issue:16

    Topics: Angiotensin-Converting Enzyme 2; Glucosides; Humans; Hydrolyzable Tannins; Ligands; Molecular Dynamics Simulation; Protein Interaction Domains and Motifs; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Virus Internalization

2021
Rambutan genome revealed gene networks for spine formation and aril development.
    The Plant journal : for cell and molecular biology, 2021, Volume: 108, Issue:4

    Topics: Adaptation, Physiological; Domestication; Flowers; Fruit; Gene Expression Profiling; Gene Regulatory Networks; Genome, Plant; Genomics; Glucosides; Hydrolyzable Tannins; Molecular Sequence Annotation; Photosynthesis; Sapindaceae; Species Specificity; Taste; Transcriptome

2021
Geraniin inhibits whole blood IFN-γ and IL-6 and promotes IL-1β and IL-8, and stimulates calcium-dependent and sucrose-sensitive erythrocyte death.
    Toxicology and applied pharmacology, 2022, 02-01, Volume: 436

    Topics: Calcium; Cell Death; Cytokines; Eryptosis; Erythrocytes; Glucosides; Hemolysis; Humans; Hydrolyzable Tannins; Interferon-gamma; Interleukin-10; Interleukin-1beta; Interleukin-6; Interleukin-8; Sucrose; Tumor Necrosis Factor-alpha

2022
Geraniin Protects against Cerebral Ischemia/Reperfusion Injury by Suppressing Oxidative Stress and Neuronal Apoptosis via Regulation of the Nrf2/HO-1 Pathway.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Animals; Antioxidants; Apoptosis; Brain Ischemia; Cell Survival; Glucosides; Heme Oxygenase (Decyclizing); Hydrolyzable Tannins; Mice; Neurons; Neuroprotective Agents; NF-E2-Related Factor 2; Nitric Oxide Synthase Type I; Oxidative Stress; PC12 Cells; Rats; Reperfusion Injury; Signal Transduction

2022
Anti-atherosclerotic effects of geraniin through the gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway in mice.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2022, Volume: 101

    Topics: Animals; Atherosclerosis; Gastrointestinal Microbiome; Glucosides; Hydrolyzable Tannins; Methylamines; Mice; Mice, Inbred C57BL; RNA, Ribosomal, 16S

2022