gentianine and mangiferin

To study the metabolism of total terpene ketones from Swertia mussotii with human intestinal bacteria.. Total terpene ketones were incubated with human intestinal bacteria under an anaerobic environment and at 37 degrees C. The metabolites were extracted by ethyl acetate processing, detected by HPLC-DAD method. A qualitative analysis was made for its metabolites by HPLC-MS.. Eight metabolites were detected from total terpene ketones from S. mussotii with human intestinal bacteria, and two of them were preliminarily identified as gentianine and mangiferin aglycon.. Total terpene ketones can be metabolized with human intestinal bacteria, which provides basis for experiments on the metabolism process total terpene ketones from S. mussotii with human intestinal bacteria.

Topics: Alkaloids; Anaerobiosis; Bacteria; Chromatography, High Pressure Liquid; Humans; Intestinal Mucosa; Intestines; Ketones; Mass Spectrometry; Swertia; Terpenes; Xanthones