gentamicin and ethacrynic acid

gentamicin has been researched along with ethacrynic acid in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19908 (40.00)18.7374
1990's7 (35.00)18.2507
2000's4 (20.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hybels, RL1
Federspil, P2
Lonsbury-Martin, BL; Martin, GK; Whitehead, ML1
Aran, JM; Dulon, D; Erre, JP; Hayashida, T; Hiel, H; Schamel, A1
Aran, JM; Portmann, M1
Buss, WC; Kauten, R; Piatt, MK1
Paparella, MM1
Hawkins, JE; Johnsson, LG1
Amiel, C; Manuel, C; Meulemans, A; Sterkers, O; Tran Ba Huy, P; Wassef, M1
Lautermann, J; Schacht, J2
Butterfield, DA; Clerici, WJ; DiMartino, DL; Hensley, K1
Conlon, BJ; McSwain, SD; Smith, DW1
Ding, D; Jiang, H; McFadden, SL; Salvi, RJ; Woo, JM1
Browne, RW; Ding, D; McFadden, SL; Salvi, RJ1
Ding, D; Jiang, H; McFadden, SL; Salvi, RJ1
Cheung, PY; Etches, PC; Peliowski, A; Robertson, CM; Tyebkhan, JM1
Ding, D; Jiang, H; Salvi, RJ1

Trials

1 trial(s) available for gentamicin and ethacrynic acid

ArticleYear
Ototoxic drugs and sensorineural hearing loss following severe neonatal respiratory failure.
    Acta paediatrica (Oslo, Norway : 1992), 2006, Volume: 95, Issue:2

    Topics: Amikacin; Aminoglycosides; Anti-Infective Agents; Audiometry, Pure-Tone; Auditory Threshold; Diuretics; Ethacrynic Acid; Female; Furosemide; Gentamicins; Hearing Loss, Sensorineural; Humans; Infant, Newborn; Male; Pancuronium; Respiratory Insufficiency; Severity of Illness Index; Tobramycin; Vancomycin; Vecuronium Bromide

2006

Other Studies

19 other study(ies) available for gentamicin and ethacrynic acid

ArticleYear
Drug toxicity of the inner ear.
    The Medical clinics of North America, 1979, Volume: 63, Issue:2

    Topics: Animals; Chloroquine; Dihydrostreptomycin Sulfate; Ethacrynic Acid; Furosemide; Gentamicins; Humans; Kanamycin; Labyrinth Diseases; Neomycin; Quinine; Salicylates; Streptomycin; Tobramycin

1979
[Ototoxicity of the aminoglycoside antibiotics (author's transl)].
    Infection, 1976, Volume: 4, Issue:4

    Topics: Acid Phosphatase; Alkaline Phosphatase; Amikacin; Animals; Anti-Bacterial Agents; Child; Ear, Inner; Esterases; Ethacrynic Acid; Gentamicins; Guinea Pigs; Humans; Kidney Diseases; Noise; Otitis Media; Sisomicin; Sulfhydryl Compounds; Tobramycin

1976
Evidence for two discrete sources of 2f1-f2 distortion-product otoacoustic emission in rabbit. II: Differential physiological vulnerability.
    The Journal of the Acoustical Society of America, 1992, Volume: 92, Issue:5

    Topics: Acoustic Stimulation; Acoustics; Animals; Audiometry; Auditory Fatigue; Cadaver; Ethacrynic Acid; Gentamicins; Hypoxia; Otoacoustic Emissions, Spontaneous; Rabbits; Sound Spectrography; Time Factors

1992
Cellular and subcellular localization of tritiated gentamicin in the guinea pig cochlea following combined treatment with ethacrynic acid.
    Hearing research, 1992, Volume: 57, Issue:2

    Topics: Action Potentials; Animals; Auditory Threshold; Biological Transport, Active; Cochlea; Drug Interactions; Ethacrynic Acid; Female; Gentamicins; Guinea Pigs; Hair Cells, Auditory; Histocytochemistry; Kidney; Subcellular Fractions

1992
[Synergism between noise and ototoxic drugs: new experimental data].
    Bulletin de l'Academie nationale de medecine, 1990, Volume: 174, Issue:7

    Topics: Animals; Ethacrynic Acid; Gentamicins; Guinea Pigs; Hearing; Hearing Loss, Sensorineural; Noise

1990
Inhibitory effects of gentamicin and ethacrynic acid on mammalian microsomal protein synthesis.
    The Journal of antimicrobial chemotherapy, 1985, Volume: 15, Issue:1

    Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Combinations; Ear, Inner; Ethacrynic Acid; Gentamicins; In Vitro Techniques; Microsomes; Nerve Tissue Proteins; Protein Biosynthesis; Rats; Rats, Inbred Strains

1985
The dizzy patient.
    Postgraduate medicine, 1972, Volume: 52, Issue:2

    Topics: Diazepam; Drainage; Ear; Ear Neoplasms; Ethacrynic Acid; Gentamicins; Hearing Disorders; Humans; Inflammation; Kanamycin; Labyrinth Diseases; Meniere Disease; Neoplasm Metastasis; Posture; Streptomycin; Vertigo; Vestibular Function Tests; Vestibular Nerve; Viomycin

1972
Drug-induced deafness.
    JAMA, 1973, Apr-23, Volume: 224, Issue:4

    Topics: Adult; Anti-Bacterial Agents; Aspirin; Deafness; Drug-Related Side Effects and Adverse Reactions; Ethacrynic Acid; Gentamicins; Glycosides; Humans; Injections, Intravenous; Kanamycin; Male; Middle Aged; Neomycin; Paromomycin; Quinidine

1973
Strial atrophy in clinical and experimental deafness.
    The Laryngoscope, 1972, Volume: 82, Issue:7

    Topics: Animals; Atrophy; Basement Membrane; Blood Vessels; Cochlea; Deafness; Dogs; Ethacrynic Acid; Gentamicins; Guinea Pigs; Hearing Loss, Noise-Induced; Labyrinth Diseases; Neomycin; Organ of Corti; Presbycusis

1972
[Review of observed gentamicin ototoxicity cases in Germany].
    HNO, 1971, Volume: 19, Issue:11

    Topics: Adolescent; Adult; Aged; Diabetes Complications; Drug Synergism; Ethacrynic Acid; Gentamicins; Germany, West; Hearing Disorders; Humans; Kidney Failure, Chronic; Labyrinth Diseases; Middle Aged; Prognosis

1971
Ethacrynic acid facilitates gentamicin entry into endolymph of the rat.
    Hearing research, 1983, Volume: 11, Issue:2

    Topics: Animals; Endolymph; Ethacrynic Acid; Gentamicins; Kinetics; Labyrinthine Fluids; Male; Potassium; Rats; Rats, Inbred Strains; Sodium; Stria Vascularis

1983
[Reduced nutritional status enhances ototoxicity].
    Laryngo- rhino- otologie, 1995, Volume: 74, Issue:12

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Auditory Pathways; Auditory Threshold; Body Weight; Brain Stem; Cisplatin; Diuretics; Dose-Response Relationship, Drug; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Gentamicins; Guinea Pigs; Hair Cells, Auditory; Metabolic Clearance Rate; Organ of Corti; Protein-Energy Malnutrition

1995
A sensitive animal model to assess acute and chronic ototoxic effects.
    Archives of otolaryngology--head & neck surgery, 1996, Volume: 122, Issue:8

    Topics: Acute Disease; Animals; Anti-Bacterial Agents; Auditory Threshold; Diet, Protein-Restricted; Disease Models, Animal; Diuretics; Ethacrynic Acid; Evoked Potentials, Auditory, Brain Stem; Gentamicins; Guinea Pigs; Hearing Loss, Sensorineural; Male; Organ of Corti

1996
Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants.
    Hearing research, 1996, Sep-01, Volume: 98, Issue:1-2

    Topics: Analgesics, Non-Narcotic; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Cisplatin; Cochlea; Cyclic N-Oxides; Diuretics; Electron Spin Resonance Spectroscopy; Ethacrynic Acid; Female; Furosemide; Gentamicins; Guinea Pigs; Hydrogen Peroxide; Hydroxyl Radical; Kanamycin; Male; Perilymph; Quinine; Spin Labels; Trimethyltin Compounds

1996
Topical gentamicin and ethacrynic acid: effects on cochlear function.
    The Laryngoscope, 1998, Volume: 108, Issue:7

    Topics: Action Potentials; Administration, Topical; Animals; Anti-Bacterial Agents; Auditory Threshold; Cochlea; Diuretics; Drug Evaluation, Preclinical; Drug Synergism; Drug Therapy, Combination; Electrodes, Implanted; Ethacrynic Acid; Gentamicins; Guinea Pigs; Infusions, Intravenous; Random Allocation

1998
Chinchilla models of selective cochlear hair cell loss.
    Hearing research, 2002, Volume: 174, Issue:1-2

    Topics: Animals; Anti-Bacterial Agents; Body Weight; Cell Death; Chinchilla; Cochlea; Diuretics; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Ethacrynic Acid; Gentamicins; Hair Cells, Auditory; Hair Cells, Vestibular

2002
Late dosing with ethacrynic acid can reduce gentamicin concentration in perilymph and protect cochlear hair cells.
    Hearing research, 2003, Volume: 185, Issue:1-2

    Topics: Action Potentials; Aminoglycosides; Animals; Anti-Bacterial Agents; Cell Survival; Cochlea; Differential Threshold; Drug Administration Schedule; Ethacrynic Acid; Gentamicins; Guinea Pigs; Hair Cells, Auditory; Injections, Intravenous; Neuroprotective Agents; Osmolar Concentration; Perilymph

2003
Time course of efferent fiber and spiral ganglion cell degeneration following complete hair cell loss in the chinchilla.
    Brain research, 2004, Jan-30, Volume: 997, Issue:1

    Topics: Acetylcholinesterase; Action Potentials; Animals; Cell Count; Cell Death; Chinchilla; Cochlear Microphonic Potentials; Efferent Pathways; Ethacrynic Acid; Gentamicins; Hair Cells, Auditory; Hearing Loss, Sensorineural; Immunohistochemistry; Nerve Degeneration; Organ of Corti; Silver Nitrate; Spiral Ganglion; Time Factors

2004
Mechanisms of rapid sensory hair-cell death following co-administration of gentamicin and ethacrynic acid.
    Hearing research, 2010, Volume: 259, Issue:1-2

    Topics: Animals; Anti-Bacterial Agents; Apoptosis; Caspase 3; Caspase 8; Caspase 9; Cell Death; Chinchilla; Cytochromes c; Drug Synergism; Ethacrynic Acid; Gentamicins; Hair Cells, Auditory; Hair Cells, Auditory, Outer; Membrane Potential, Mitochondrial; Signal Transduction; Succinate Dehydrogenase

2010