genistein and alvocidib

genistein has been researched along with alvocidib* in 2 studies

Other Studies

2 other study(ies) available for genistein and alvocidib

Article	Year
A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets. Journal of natural products, 2006, Volume: 69, Issue:1 The relationship between a natural product's biosynthetic enzyme and its therapeutic target is unknown. The concept of protein fold topologies, as a determining factor in recognition, has been developed through molecular modeling techniques. We have shown that biosynthetic enzymes and the therapeutic targets of three classes of natural products that inhibit protein kinases share a common protein fold topology (PFT) and cavity recognition points despite having different fold type classifications. The clinical agent flavopiridol would have been identified by this new approach. Topics: Biological Products; Flavonoids; Models, Molecular; Molecular Structure; Piperidines; Plants, Medicinal; Protein Conformation; Protein Folding; Protein Kinase Inhibitors; Proteins	2006
Structure-activity relationship studies of flavopiridol analogues. Bioorganic & medicinal chemistry letters, 2000, May-15, Volume: 10, Issue:10 Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity. Topics: Antineoplastic Agents; Chromones; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Flavonoids; Piperidines; Pyridines; Structure-Activity Relationship; Tumor Cells, Cultured	2000

Article

Year

A common protein fold topology shared by flavonoid biosynthetic enzymes and therapeutic targets.

Journal of natural products, 2006, Volume: 69, Issue:1

The relationship between a natural product's biosynthetic enzyme and its therapeutic target is unknown. The concept of protein fold topologies, as a determining factor in recognition, has been developed through molecular modeling techniques. We have shown that biosynthetic enzymes and the therapeutic targets of three classes of natural products that inhibit protein kinases share a common protein fold topology (PFT) and cavity recognition points despite having different fold type classifications. The clinical agent flavopiridol would have been identified by this new approach.

Topics: Biological Products; Flavonoids; Models, Molecular; Molecular Structure; Piperidines; Plants, Medicinal; Protein Conformation; Protein Folding; Protein Kinase Inhibitors; Proteins

2006

Structure-activity relationship studies of flavopiridol analogues.

Bioorganic & medicinal chemistry letters, 2000, May-15, Volume: 10, Issue:10

Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity.

Topics: Antineoplastic Agents; Chromones; Cyclin-Dependent Kinases; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Flavonoids; Piperidines; Pyridines; Structure-Activity Relationship; Tumor Cells, Cultured

2000