gemfibrozil and warfarin

gemfibrozil has been researched along with warfarin in 21 studies

Research

Studies (21)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (19.05)	18.2507
2000's	7 (33.33)	29.6817
2010's	8 (38.10)	24.3611
2020's	2 (9.52)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Fent, K; Popovic, M; Smital, T; Zaja, R	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Kashihara, M; Mizuguchi, M; Yokoyama, T	1
Ahmad, S	2
Miller, DB; Spence, JD	1
Keng, HC; Rindone, JP	1
Backman, JT; Lilja, JJ; Neuvonen, PJ	1
Balchen, M; Gjelstad, A; Pedersen-Bjergaard, S; Rasmussen, KE	1
Dixon, DL; Williams, VG	1
Aktan, G; Arkenau, HT; Blackman, SC; Botbyl, J; Carson, SW; Gordon, MS; Grossmann, KF; Infante, JR; Kendra, K; LoRusso, PM; Middleton, MR; Ouellet, D; Pant, S; Patel, M; Richards-Peterson, LE; Sharma, S; Suttle, AB	1
Chamani, M; Ghani, M; Jafari, Z; Maleki, B	1

Reviews

3 review(s) available for gemfibrozil and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Clinical pharmacokinetics of fibric acid derivatives (fibrates). Clinical pharmacokinetics, 1998, Volume: 34, Issue:2 Topics: Anticholesteremic Agents; Clofibrate; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Fenofibrate; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Liver; Mixed Function Oxygenases; Warfarin	1998
Interaction between gemfibrozil and warfarin: case report and review of the literature. Pharmacotherapy, 2009, Volume: 29, Issue:6 Topics: Anticoagulants; Atrial Fibrillation; Drug Interactions; Follow-Up Studies; Gemfibrozil; Humans; Hypolipidemic Agents; International Normalized Ratio; Male; Middle Aged; Muscular Diseases; Time Factors; Treatment Outcome; Warfarin	2009

Trials

2 trial(s) available for gemfibrozil and warfarin

Article	Year
Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects. British journal of clinical pharmacology, 2005, Volume: 59, Issue:4 Topics: Adult; Anticoagulants; Area Under Curve; Blood Coagulation; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gemfibrozil; Humans; Hypolipidemic Agents; Male; Partial Thromboplastin Time; Warfarin	2005
Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib. Journal of clinical pharmacology, 2015, Volume: 55, Issue:4 Topics: Anticoagulants; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Gemfibrozil; Humans; Imidazoles; Ketoconazole; Male; Middle Aged; Oximes; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Warfarin	2015

Article

Year

Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects.

British journal of clinical pharmacology, 2005, Volume: 59, Issue:4

Topics: Adult; Anticoagulants; Area Under Curve; Blood Coagulation; Chromatography, High Pressure Liquid; Cross-Over Studies; Female; Gemfibrozil; Humans; Hypolipidemic Agents; Male; Partial Thromboplastin Time; Warfarin

2005

Assessment of the drug interaction potential and single- and repeat-dose pharmacokinetics of the BRAF inhibitor dabrafenib.

Journal of clinical pharmacology, 2015, Volume: 55, Issue:4

Topics: Anticoagulants; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Gemfibrozil; Humans; Imidazoles; Ketoconazole; Male; Middle Aged; Oximes; Protein Kinase Inhibitors; Proto-Oncogene Proteins B-raf; Warfarin

2015

Other Studies

16 other study(ies) available for gemfibrozil and warfarin

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
First-principle, structure-based prediction of hepatic metabolic clearance values in human. European journal of medicinal chemistry, 2009, Volume: 44, Issue:4 Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide. The Journal of biological chemistry, 2013, Nov-22, Volume: 288, Issue:47 Topics: Animals; Evolution, Molecular; Glycosylation; Gonadal Steroid Hormones; HEK293 Cells; Humans; Ion Transport; Organic Anion Transporters; Protein Multimerization; Zebrafish; Zebrafish Proteins	2013
Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors. Journal of medicinal chemistry, 2021, 10-14, Volume: 64, Issue:19 Topics: Amyloid Neuropathies, Familial; Anthelmintics; Bithionol; Crystallography, X-Ray; Drug Repositioning; Humans; Prealbumin; Thermodynamics; Triclabendazole	2021
Gemfibrozil interaction with warfarin sodium (coumadin) Chest, 1990, Volume: 98, Issue:4 Topics: Adult; Drug Interactions; Female; Gemfibrozil; Humans; Warfarin	1990
Warfarin therapy. Mayo Clinic proceedings, 1995, Volume: 70, Issue:5 Topics: Drug Synergism; Gemfibrozil; Humans; Lovastatin; Warfarin	1995
Gemfibrozil-warfarin drug interaction resulting in profound hypoprothrombinemia. Chest, 1998, Volume: 114, Issue:2 Topics: Aged; Anticoagulants; Drug Interactions; Follow-Up Studies; Gemfibrozil; Hemorrhage; Humans; Hyperlipidemias; Hypolipidemic Agents; Hypoprothrombinemias; Male; Thrombophlebitis; Warfarin	1998
Electrokinetic migration of acidic drugs across a supported liquid membrane. Journal of chromatography. A, 2007, Jun-08, Volume: 1152, Issue:1-2 Topics: Acids; Chromatography, Micellar Electrokinetic Capillary; Electrophoresis, Capillary; Flurbiprofen; Gemfibrozil; Heptanol; Hydrogen-Ion Concentration; Ketoprofen; Membranes, Artificial; Naproxen; Pharmaceutical Preparations; Probenecid; Reproducibility of Results; Warfarin	2007
Magnetic solid-phase extraction of warfarin and gemfibrozil in biological samples using polydopamine-coated magnetic nanoparticles via core-shell nanostructure. Journal of separation science, 2023, Volume: 46, Issue:2 Topics: Chromatography, High Pressure Liquid; Gemfibrozil; Magnetic Phenomena; Magnetite Nanoparticles; Solid Phase Extraction; Warfarin	2023