gemfibrozil has been researched along with montelukast in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 9 (90.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Backman, JT; Filppula, A; Karonen, T; Laitila, J; Neuvonen, PJ; Niemi, M | 1 |
| Backman, JT; Karonen, T; Neuvonen, PJ | 1 |
| Aatsinki, SM; Hokkanen, J; Lassila, T; Mattila, S; Tolonen, A; Turpeinen, M | 1 |
| Bi, Y; El-Kattan, AF; Eng, H; Kalgutkar, AS; Kimoto, E; Lin, J; Rodrigues, AD; Scialis, R; Tremaine, LM; Varma, MV | 1 |
1 review(s) available for gemfibrozil and montelukast
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
2 trial(s) available for gemfibrozil and montelukast
| Article | Year |
|---|---|
Gemfibrozil markedly increases the plasma concentrations of montelukast: a previously unrecognized role for CYP2C8 in the metabolism of montelukast.
Topics: Acetates; Adult; Anti-Asthmatic Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 CYP2C8; DNA; Drug Interactions; Female; Gemfibrozil; Genotype; Glucuronides; Half-Life; Humans; Hypolipidemic Agents; Leukotriene Antagonists; Male; Mass Spectrometry; Microsomes, Liver; Quinolines; Sulfides; Young Adult | 2010 |
CYP2C8 but not CYP3A4 is important in the pharmacokinetics of montelukast.
Topics: 14-alpha Demethylase Inhibitors; Acetates; Adult; Anti-Asthmatic Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Drug Interactions; Female; Gemfibrozil; Humans; Hypolipidemic Agents; Itraconazole; Male; Quinolines; Sulfides; Young Adult | 2012 |
7 other study(ies) available for gemfibrozil and montelukast
| Article | Year |
|---|---|
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Toxicity of Carboxylic Acid-Containing Drugs: The Role of Acyl Migration and CoA Conjugation Investigated.
Topics: Acetates; Acyl Coenzyme A; Acylation; Carboxylic Acids; Chemical and Drug Induced Liver Injury; Chromatography, Liquid; Cyclopropanes; Gemfibrozil; Humans; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Quinolines; Sulfides; Tolmetin | 2015 |
Transporter-Mediated Hepatic Uptake Plays an Important Role in the Pharmacokinetics and Drug-Drug Interactions of Montelukast.
Topics: Acetates; Animals; Clarithromycin; Cyclopropanes; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Gemfibrozil; Haplorhini; Hepatocytes; Liver; Liver-Specific Organic Anion Transporter 1; Models, Biological; Nucleic Acid Synthesis Inhibitors; Organic Anion Transporters; Quinolines; Rats; Rifampin; Sulfides | 2017 |