gemfibrozil has been researched along with cyclosporine in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (24.14) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 16 (55.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ekins, S; Williams, AJ; Xu, JJ | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Barton, P; Ismair, M; Jupp, R; Riley, RJ; Soars, MG | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Fent, K; Popovic, M; Smital, T; Zaja, R | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Breckenridge, C; Gault, MH; Harnett, J; Longerich, LL; Purchase, L | 1 |
| Aridge, D; Bastani, B; Garvin, PJ; Heisler, T; Lindsey, L; Puntney, G; Robinson, S; Solomon, H | 1 |
| Cohen, PR | 1 |
| Boissonnat, P; de Lorgeril, M; Dureau, G; Monjaud, I; Salen, P | 1 |
| Angelin, B; Fehrman-Ekholm, I; Jogestrand, T | 1 |
| Miller, DB; Spence, JD | 1 |
| Capone, D; D'Alessandro, R; De Marino, V; Imperatore, P; Pisanti, N; Stanziale, P | 1 |
| Limanni, A; Maxa, JL; Melton, LB; Ogu, CC; Sills, MN | 1 |
| Chanteux, H; Michot, JM; Mingeot-Leclercq, MP; Seral, C; Tulkens, PM; Van Bambeke, F | 1 |
| Christopoulos, S; Eisenberg, MJ; Jamal, SM | 1 |
| Galetin, A; Hinton, LK; Houston, JB | 1 |
| Bergman, E; Bondesson, U; Fridblom, P; Hedeland, M; Knutson, L; Lennernäs, H; Lundahl, A | 1 |
| Bergman, A; Feng, B; Goosen, TC; Lai, Y; Litchfield, J; Varma, MV | 1 |
| Izumi, S; Komori, T; Kusuhara, H; Maeda, K; Nozaki, Y; Sugiyama, Y; Takenaka, O | 1 |
| Leil, T; Wang, Q; Zheng, M | 1 |
| Kim, SJ; Sugiyama, Y; Toshimoto, K; Yao, Y; Yoshikado, T | 2 |
| Chen, EC; Chen, Y; Choo, EF; Liu, L; Ma, F; Mao, J; Sahasranaman, S; Zhu, R | 1 |
3 review(s) available for gemfibrozil and cyclosporine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Clinical pharmacokinetics of fibric acid derivatives (fibrates).
Topics: Anticholesteremic Agents; Clofibrate; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Fenofibrate; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Liver; Mixed Function Oxygenases; Warfarin | 1998 |
Rhabdomyolysis associated with hydroxymethylglutaryl-coenzyme A reductase inhibitors.
Topics: Cyclosporine; Cytochrome P-450 CYP4A; Dose-Response Relationship, Drug; Drug Interactions; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipidemias; Immunosuppressive Agents; Incidence; Rhabdomyolysis; Survival Rate | 2004 |
1 trial(s) available for gemfibrozil and cyclosporine
| Article | Year |
|---|---|
Decreased cyclosporine levels during gemfibrozil treatment of hyperlipidemia after kidney transplantation.
Topics: Cyclosporine; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Immunosuppressive Agents; Kidney Transplantation | 1996 |
25 other study(ies) available for gemfibrozil and cyclosporine
| Article | Year |
|---|---|
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.
Topics: Cell Line; Drug Discovery; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Molecular characterization of zebrafish Oatp1d1 (Slco1d1), a novel organic anion-transporting polypeptide.
Topics: Animals; Evolution, Molecular; Glycosylation; Gonadal Steroid Hormones; HEK293 Cells; Humans; Ion Transport; Organic Anion Transporters; Protein Multimerization; Zebrafish; Zebrafish Proteins | 2013 |
Comparison of Lp(a) concentrations and some potential effects in hemodialysis, CAPD, transplantation, and control groups, and review of the literature.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Apolipoprotein B-100; Apolipoproteins A; Apolipoproteins B; Cardiovascular Diseases; Child; Cholesterol; Cyclosporine; Data Interpretation, Statistical; Diabetes Mellitus, Type 1; Enzyme-Linked Immunosorbent Assay; Female; Gemfibrozil; Graft Occlusion, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Isoenzymes; Kidney; Kidney Function Tests; Kidney Transplantation; Lipoproteins, HDL; Lipoproteins, LDL; Male; Middle Aged; Myocardial Ischemia; Peritoneal Dialysis, Continuous Ambulatory; Radioimmunoassay; Reference Values; Renal Dialysis; Triglycerides; Ultrasonography | 1995 |
Post-transplant hyperlipidemia: risk factors and response to dietary modification and gemfibrozil therapy.
Topics: Adult; Age Factors; Black People; Blood Glucose; Blood Pressure; Body Weight; Cholesterol; Cholesterol, Dietary; Combined Modality Therapy; Creatinine; Cyclosporine; Diabetes Complications; Diet, Fat-Restricted; Female; Follow-Up Studies; Gemfibrozil; Humans; Hypercholesterolemia; Hypolipidemic Agents; Immunosuppressive Agents; Kidney Transplantation; Male; Patient Compliance; Retrospective Studies; Risk Factors; Serum Albumin; Sex Factors; White People | 1995 |
A therapeutic alternative for managing cyclosporine- and retinoid-induced hypertriglyceridemia.
Topics: Cyclosporine; Gemfibrozil; Humans; Hypertriglyceridemia; Retinoids | 1993 |
Fenofibrate, probucol, and other lipid-lowering treatments in heart transplant recipients.
Topics: Anticholesteremic Agents; Cholestyramine Resin; Cyclosporine; Drug Interactions; Fenofibrate; Gemfibrozil; Heart Transplantation; Humans; Hypolipidemic Agents; Immunosuppressive Agents; Lovastatin; Probucol; Simvastatin | 1996 |
Lack of effect of gemfibrozil on cyclosporine blood concentrations in kidney-transplanted patients.
Topics: Adult; Cyclosporine; Drug Interactions; Female; Gemfibrozil; Humans; Hypertriglyceridemia; Hypolipidemic Agents; Immunosuppressive Agents; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; Time Factors | 1998 |
Rhabdomyolysis after concomitant use of cyclosporine, simvastatin, gemfibrozil, and itraconazole.
Topics: Antifungal Agents; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Fatal Outcome; Gemfibrozil; Humans; Hypolipidemic Agents; Immunosuppressive Agents; Itraconazole; Male; Middle Aged; Mixed Function Oxygenases; Organ Transplantation; Rhabdomyolysis; Risk Assessment; Simvastatin | 2002 |
Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.
Topics: Acridines; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azithromycin; Cell Line; Cyclosporine; Cytosol; Gemfibrozil; Isoquinolines; Lysosomes; Macrophages; Mice; Microscopy, Confocal; Monensin; Probenecid; Tetrahydroisoquinolines; Verapamil | 2003 |
Multiple inhibition mechanisms and prediction of drug-drug interactions: status of metabolism and transporter models as exemplified by gemfibrozil-drug interactions.
Topics: Area Under Curve; Aryl Hydrocarbon Hydroxylases; Carrier Proteins; Cell Line; Cyclosporine; Cytochrome P-450 CYP2C8; Databases, Factual; Drug Interactions; Enzyme Inhibitors; Gemfibrozil; Glucuronides; Humans; Hypolipidemic Agents; Immunosuppressive Agents; Kinetics; Predictive Value of Tests | 2008 |
Enterohepatic disposition of rosuvastatin in pigs and the impact of concomitant dosing with cyclosporine and gemfibrozil.
Topics: Administration, Oral; Animals; Area Under Curve; Bile; Cyclosporine; Enterohepatic Circulation; Female; Fluorobenzenes; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infusions, Intravenous; Injections, Intravenous; Intestinal Absorption; Jejunum; Liver; Male; Microsomes, Liver; Models, Biological; Orchiectomy; Pyrimidines; Rosuvastatin Calcium; Sulfonamides; Swine | 2009 |
Physiologically based modeling of pravastatin transporter-mediated hepatobiliary disposition and drug-drug interactions.
Topics: Adolescent; Adult; Aged; Area Under Curve; Biological Transport; Cells, Cultured; Computer Simulation; Cyclosporine; Drug Interactions; Enzyme Inhibitors; Female; Gemfibrozil; Hepatocytes; Humans; Liver; Liver-Specific Organic Anion Transporter 1; Male; Middle Aged; Organic Anion Transporters; Pravastatin; Rifampin; Young Adult | 2012 |
Investigation of the impact of substrate selection on in vitro organic anion transporting polypeptide 1B1 inhibition profiles for the prediction of drug-drug interactions.
Topics: Antihypertensive Agents; Binding, Competitive; Biological Transport; Cyclohexanes; Cyclosporine; Drug Evaluation, Preclinical; Drug Interactions; Estradiol; Gemfibrozil; HEK293 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Kinetics; Liver-Specific Organic Anion Transporter 1; Membrane Transport Modulators; Models, Biological; Nateglinide; Organic Anion Transporters; Phenylalanine; Recombinant Proteins; Rifampin; Sulfonamides; Torsemide | 2015 |
Investigating Transporter-Mediated Drug-Drug Interactions Using a Physiologically Based Pharmacokinetic Model of Rosuvastatin.
Topics: Administration, Intravenous; Administration, Oral; Area Under Curve; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Gemfibrozil; Gene Expression Regulation; Humans; Liver-Specific Organic Anion Transporter 1; Models, Theoretical; Neoplasm Proteins; Organic Anion Transporters, Sodium-Independent; Rifampin; Rosuvastatin Calcium; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2017 |
Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data.
Topics: Biological Transport; Carbamates; Computer Simulation; Cyclosporine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Inhibitors; Gemfibrozil; Humans; Hypoglycemic Agents; Liver-Specific Organic Anion Transporter 1; Models, Biological; Piperidines | 2017 |
Quantitative Analysis of Complex Drug-Drug Interactions between Cerivastatin and Metabolism/Transport Inhibitors Using Physiologically Based Pharmacokinetic Modeling.
Topics: Biological Transport; Cyclosporine; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Gemfibrozil; Glucuronides; Hepatocytes; Humans; Liver; Liver-Specific Organic Anion Transporter 1; Models, Biological; Pyridines | 2018 |
Assessment of OATP transporter-mediated drug-drug interaction using physiologically-based pharmacokinetic (PBPK) modeling - a case example.
Topics: Area Under Curve; Cinnamates; Cyclosporine; Drug Interactions; Gemfibrozil; Humans; Indazoles; Liver-Specific Organic Anion Transporter 1; Models, Biological; Pravastatin; Rifampin; Solute Carrier Organic Anion Transporter Family Member 1B3 | 2018 |