gemfibrozil and clopidogrel

gemfibrozil has been researched along with clopidogrel in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's7 (70.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Ballard, TE; Henderson, JL; Kalgutkar, AS; Obach, RS; Orr, ST; Ripp, SL; Scott, DO; Sun, H1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Dalvie, D; Fu, Y; Khojasteh, SC; Ma, Y; Zhang, D1
Gami, A1
Arnaout, A; Malcolm, J; Sigal, R1
Jójártné, LO; Mártha, C; Szabóné, RP1
Backman, JT; Itkonen, MK; Neuvonen, M; Neuvonen, PJ; Niemi, M; Tornio, A1
Backman, JT; Evangelista, EA; Filppula, AM; Kahma, H; Launiainen, T; Neuvonen, M; Totah, RA; Viinamäki, J1
Shah, MB1

Reviews

6 review(s) available for gemfibrozil and clopidogrel

ArticleYear
Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
    Journal of medicinal chemistry, 2012, Jun-14, Volume: 55, Issue:11

    Topics: Animals; Apoproteins; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Drug Interactions; Heme; Humans; Models, Biological; Pharmacokinetics; Structure-Activity Relationship; Time Factors

2012
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Glucuronides as Potential Anionic Substrates of Human Cytochrome P450 2C8 (CYP2C8).
    Journal of medicinal chemistry, 2017, 11-09, Volume: 60, Issue:21

    Topics: Anions; Binding Sites; Cytochrome P-450 CYP2C8; Drug Interactions; Glucuronides; Humans; Ligands

2017
Secondary prevention of ischaemic cardiac events.
    Clinical evidence, 2006, Issue:15

    Topics: Adrenergic beta-Antagonists; Angioplasty, Balloon, Coronary; Angiotensin-Converting Enzyme Inhibitors; Anticoagulants; Antihypertensive Agents; Aspirin; Clopidogrel; Coronary Artery Bypass; Diet; Drug Therapy, Combination; Estrogen Replacement Therapy; Exercise; Female; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Ischemia; Platelet Aggregation Inhibitors; Smoking Cessation; Ticlopidine

2006
Prevention of cardiovascular events in diabetes.
    Clinical evidence, 2006, Issue:15

    Topics: Angioplasty, Balloon; Antihypertensive Agents; Aspirin; Bezafibrate; Cardiovascular Diseases; Clopidogrel; Diabetic Angiopathies; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hyperlipidemias; Hypertension; Hypolipidemic Agents; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Smoking Cessation; Ticlopidine

2006
Inhibition of CYP2C8 by Acyl Glucuronides of Gemfibrozil and Clopidogrel: Pharmacological Significance, Progress and Challenges.
    Biomolecules, 2022, 09-01, Volume: 12, Issue:9

    Topics: Cholesterol; Clopidogrel; Cytochrome P-450 CYP2C8; Gemfibrozil; Glucuronides; Heme; Platelet Aggregation Inhibitors; Triglycerides

2022

Other Studies

4 other study(ies) available for gemfibrozil and clopidogrel

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
[Amorphous form in pharmaceutical technological research].
    Acta pharmaceutica Hungarica, 2011, Volume: 81, Issue:1

    Topics: Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Chlorhexidine; Clopidogrel; Dihydropyridines; Gemfibrozil; Glass; Ibuprofen; Loratadine; Meloxicam; Pharmaceutical Preparations; Piroxicam; Sorbitol; Technology, Pharmaceutical; Thiazines; Thiazoles; Ticlopidine

2011
Clopidogrel and Gemfibrozil Strongly Inhibit the CYP2C8-Dependent Formation of 3-Hydroxydesloratadine and Increase Desloratadine Exposure In Humans.
    Drug metabolism and disposition: the biological fate of chemicals, 2019, Volume: 47, Issue:4

    Topics: Adult; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Biotransformation; Clopidogrel; Cross-Over Studies; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Drug Interactions; Female; Gemfibrozil; Genotype; Glucuronides; Humans; Hypolipidemic Agents; Loratadine; Male; Young Adult

2019
Critical Differences between Enzyme Sources in Sensitivity to Detect Time-Dependent Inactivation of CYP2C8.
    Drug metabolism and disposition: the biological fate of chemicals, 2019, Volume: 47, Issue:4

    Topics: Amiodarone; Clopidogrel; Cytochrome P-450 CYP2C8; Gemfibrozil; Glucuronides; Humans; Kinetics; Microsomes, Liver; Phenelzine; Sensitivity and Specificity

2019