gemfibrozil and clofibric acid

gemfibrozil has been researched along with clofibric acid in 80 studies

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (8.75)	18.7374
1990's	30 (37.50)	18.2507
2000's	34 (42.50)	29.6817
2010's	9 (11.25)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abraham, DJ; Fatope, MO	1
Abraham, DJ; Kennedy, PE; Mehanna, AS; Patwa, DC; Williams, FL	1
Maillet, EL; Margolskee, RF; Mosinger, B	1
Fujiwara, R; Koga, T; Nakajima, M; Yokoi, T	1
Brinkjost, T; Ehrt, C; Koch, O	1
Ammazzalorso, A; Amoia, P; Amoroso, R; Cilurzo, F; De Filippis, B; Fantacuzzi, M; Giampietro, L; Linciano, P; Maccallini, C; Petit, C	1
Adzet, T; Alegret, M; Laguna, JC; Merlos, M; Sánchez, RM	1
Adzet, T; Alegret, M; Laguna, JC; Merlos, M; Sánchez, R	1
Frishman, WH; Kahn, S; Zimetbaum, P	1
Kłosiewicz-Latoszek, L; Szostak, WB	1
Feller, DR; Kocarek, TA	1
Krause, BR; Newton, RS	1
Hunninghake, DB; Peters, JR	1
Eacho, PI; Foxworthy, PS	1
Santafé Oroz, J; Segarra Domènech, J	1
Baldwin, LA; Calabrese, EJ; Donohue, M; Kostecki, PT; Leonard, DA	1
Schonfeld, G	1
Dujovne, CA; Lozada, A	1
Wolf, HR	1
Adzet, T; Alegret, M; Laguna, JC; Merlos, M; Sánchez, RM; Vázquez, M; Viñals, M	2
Shepherd, J	1
Baigts, F; Bruckert, E; De Gennes, JL; Malbecq, W	1
Accatino, L; Amigo, L; Andrade, L; Chianale, J; Gonzalez, S; Nervi, F; Pizarro, M; Rigotti, A; Vollrath, V; Wielandt, AM	1
Walsh, KB; Wang, C	1
de Valois, JC; Kastelein, JJ; Knipscheer, HC; van den Ende, B; Wouter ten Cate, J	1
de Maat, MP; Kastelein, JJ; Kluft, C; Knipscheer, HC	1
Autier, P; Muls, E; Van Gaal, L; Vansant, G	1
Athyros, VG; Carina, MV; Didangelos, TP; Hatzikonstandinou, HA; Kontopoulos, AG; Kranitsas, DF; Papageorgiou, AA	1
Sabordo, L; Sallustio, BC	1
de Maat, MP; Kastelein, JJ; Kluft, C; Knipscheer, HC; Kockx, M; Kooistra, T; Princen, HM	1
Bruckert, E	1
Burcham, PC; Harkin, LA; Krivickas, SJ; Mann, MC; Sallustio, BC	1
de Wit, EC; Huisman, H; Kaptein, A; Neele, DM; Princen, HM	1
Sinzinger, H	1
Hashimoto, F; Hayashi, H; Taira, S	2
Kockx, M; Kooistra, T; Princen, HM	1
Wallace, KB; Zhou, S	1
Eriksson, P; Hamsten, A; Nilsson, L; Takemura, T	1
Bottoni, P; Ficarra, S; Giardina, B; Nocca, G; Puggioni, P; Remiddi, F; Rumi, C; Scatena, R; Sole, PD	1
Hemingway, CJ; Munday, MR	1
Evans, AM; Nation, RL; Sabordo, L; Sallustio, BC	1
Abramowicz, D; Antoine, M; Broeders, N; Knoop, C; Tielemans, C	1
Athyros, VG; Kontopoulos, AG; Papageorgiou, AA	1
Elisaf, M; Kakafika, A; Tsimihodimos, V	1
Aguilar-Salinas, CA; Fanghänel-Salmón, G; Gómez Pérez, FJ; González-Valdez, H; Gulías-Herrero, A; Meza, E; Monterrubio-Flores, EA; Montes, J; Sánchez, L	1
Fenselau, S; Schrezenmeir, J; Steinmetz, A	1
Jagroon, IA; Mikhailidis, DP	1
Bassett, CL; Puil, L; Wright, JM	1
Athyros, VG; Athyrou, VV; Demitriadis, DS; Kontopoulos, AG; Papageorgiou, AA; Pehlivanidis, AN	1
Arnold, HG; Baginski, RM; Jux, U; Krönke, M; Seng, PN	1
Athyros, V; Bairaktari, E; Elisaf, M; Ganotakis, E; Rizos, E; Seferiades, C; Tsimihodimos, V	1
Fujisaki, K; Itoh, Y; Maiguma, T; Makino, K; Oishi, R; Sasaguri, T; Takahashi-Yanaga, F; Teshima, D	1
Baldwin, GS; Ford, J; Lachal, S; Shulkes, A	1
Bottoni, P; De Sole, P; Ferrari, F; Giardina, B; Martorana, GE; Rossi, C; Scatena, R	1
Garbe, TR	1
Kon, YC	1
Lim, SC; Sum, CF; Tavintharan, S	1
Balice, M; Chironi, G; Del-Pino, M; Gariepy, J; Levenson, J; Simon, A	1
Davidson, MH	1
Xavier, HT	1
Elisaf, MS; Mikhailidis, DP; Milionis, HJ	1
Hauzer, A; Komsta, Ł; Majchrzak, E; Misztal, G	1
Duriez, P; Fruchart, JC	1
Barter, PJ; Rye, KA	1
Porte, C; Schnell, S; Thibaut, R	1
Backes, JM; Gibson, CA; Moriarty, PM; Ruisinger, JF	1
Berneis, K; Rizzo, M	1
Brinton, EA	1
Asami, M; Fujiwara, J; Kunikane, S; Manabe, S; Matsuda, M; Simazaki, D	1
Blanchard, JS; Della-Latta, P; Feinmark, SJ; Freeman, S; Kabbash, CA; Kaplan, G; Reich-Slotky, R; Shuman, HA; Silverstein, SC	1
Hashimoto, F; Hayashi, H; Iwasaki, K; Morita, M; Takeda, S	1
Abourbih, S; Eisenberg, MJ; Filion, KB; Genest, J; Joseph, L; Pilote, L; Poirier, P; Rinfret, S; Schiffrin, EL	1
Fernandes, D; Porte, C; Schnell, S	1
Alonso, E; Aparicio, I; Camacho-Muñoz, MA; Martín, J; Santos, JL	1
Dickenson, ER; Drewes, JE; Hoppe-Jones, C	1
Gutierrez-Macias, T; Nacheva, PM	1
Briel, M; Ferreira-González, I; Jakob, T; Nordmann, AJ; Schandelmaier, S	1
Fang, J; Guo, K; Hou, S; Hua, Z; Kong, X; Li, X; Ren, Z; Wu, Z	1

Reviews

21 review(s) available for gemfibrozil and clofibric acid

Article	Year
Effects of gemfibrozil and other fibric acid derivatives on blood lipids and lipoproteins. Journal of clinical pharmacology, 1991, Volume: 31, Issue:1 Topics: Bezafibrate; Cholesterol, HDL; Clofibric Acid; Diabetes Mellitus, Type 2; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Kidney Diseases; Lipoproteins, VLDL; Metabolic Clearance Rate; Triglycerides	1991
Effect of fibric acid derivatives on blood lipid and lipoprotein levels. The American journal of medicine, 1987, Nov-27, Volume: 83, Issue:5B Topics: Anticholesteremic Agents; Bezafibrate; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Pentanoic Acids	1987
[Pharmacologic therapy of atherosclerosis (I). Current possibilities]. Medicina clinica, 1983, Nov-26, Volume: 81, Issue:17 Topics: Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Clofibrate; Clofibric Acid; Fenofibrate; Gemfibrozil; Glycosaminoglycans; Humans; Ion Exchange Resins; Lipoproteins; Nicotinic Acids; Pentanoic Acids; Probucol	1983
The effects of fibrates on lipoprotein and hemostatic coronary risk factors. Atherosclerosis, 1994, Volume: 111, Issue:2 Topics: Arteriosclerosis; Bezafibrate; Blood Coagulation; Clofibric Acid; Coronary Disease; Fenofibrate; Fibric Acids; Gemfibrozil; Hemostasis; Humans; Hypolipidemic Agents; Lipoproteins; Risk Factors	1994
Drug interactions with fibric acids. Pharmacology & therapeutics, 1994, Volume: 63, Issue:2 Topics: Anticoagulants; Bezafibrate; Clofibrate; Clofibric Acid; Contraceptives, Oral; Coronary Disease; Drug Interactions; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemias; Hypoglycemic Agents; Hypolipidemic Agents; Lipids	1994
Mechanism of action of fibrates. Postgraduate medical journal, 1993, Volume: 69 Suppl 1 Topics: Apolipoproteins B; Bezafibrate; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Lipoproteins, LDL; Male; Receptors, LDL	1993
[Treatment of familial combined hyperlipidemia]. Annales d'endocrinologie, 1997, Volume: 58, Issue:4 Topics: Clinical Protocols; Clofibric Acid; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Lipids; Nicotinic Acids; Simvastatin	1997
[Antilipemic agents and atherothrombosis. Effects of antilipemic agents on blood platelet function, coagulation and fibrinolysis]. Deutsche medizinische Wochenschrift (1946), 1998, Sep-18, Volume: 123, Issue:38 Topics: Anticholesteremic Agents; Antiporters; Arteriosclerosis; Bezafibrate; Blood Coagulation; Blood Coagulation Factors; Blood Platelets; Clinical Trials as Topic; Clofibric Acid; Fenofibrate; Fibrinolysis; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Lovastatin; Niacin; Pravastatin; Risk Factors; Simvastatin; Thrombosis	1998
The regulation of acetyl-CoA carboxylase--a potential target for the action of hypolipidemic agents. Advances in enzyme regulation, 1999, Volume: 39 Topics: Acetyl-CoA Carboxylase; Allosteric Regulation; Amino Acid Sequence; AMP-Activated Protein Kinases; Animals; Binding Sites; Clofibric Acid; Gemfibrozil; Gene Expression Regulation, Enzymologic; Humans; Hypolipidemic Agents; Molecular Sequence Data; Multienzyme Complexes; Phosphorylation; Protein Serine-Threonine Kinases; Rats	1999
Treatment of dyslipoproteinemia in the metabolic syndrome. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2001, Volume: 109, Issue:4 Topics: Arteriosclerosis; Clofibric Acid; Coronary Disease; Diabetes Mellitus, Type 2; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipoproteinemias; Hypertriglyceridemia; Hypolipidemic Agents; Metabolic Syndrome	2001
Analysis of serious adverse events. Lipid-lowering therapy revisited. Canadian family physician Medecin de famille canadien, 2002, Volume: 48 Topics: Cardiovascular Diseases; Clofibric Acid; Gemfibrozil; Humans; Hydroxymethylglutaryl CoA Reductases; Hypolipidemic Agents; Mortality; Patient Selection; Risk	2002
Patients with low levels of high-density lipoprotein cholesterol: to treat or not to treat? Singapore medical journal, 2005, Volume: 46, Issue:10 Topics: Apoproteins; Arteriosclerosis; Carrier Proteins; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Clofibric Acid; Delayed-Action Preparations; Drug Therapy, Combination; Estrogen Replacement Therapy; Ethanol; Exercise; Gemfibrozil; Glycoproteins; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Life Style; Niacin	2005
Statin/fibrate combination in patients with metabolic syndrome or diabetes: evaluating the risks of pharmacokinetic drug interactions. Expert opinion on drug safety, 2006, Volume: 5, Issue:1 Topics: Area Under Curve; Clofibric Acid; Coronary Disease; Diabetes Mellitus, Type 2; Drug Interactions; Drug Therapy, Combination; Fenofibrate; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Metabolic Syndrome; Risk Factors	2006
Treatment of dyslipidaemias in patients with established vascular disease: a revival of the fibrates. Current medical research and opinion, 2000, Volume: 16, Issue:1 Topics: Bezafibrate; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypolipidemic Agents; Myocardial Ischemia; Randomized Controlled Trials as Topic; Triglycerides	2000
Mode of action of fibrates in the regulation of triglyceride and HDL-cholesterol metabolism. Drugs of today (Barcelona, Spain : 1998), 2006, Volume: 42, Issue:1 Topics: Animals; Anticholesteremic Agents; Atherosclerosis; Bezafibrate; Biological Transport; Cholesterol, HDL; Clofibric Acid; Coronary Artery Disease; Fenofibrate; Gemfibrozil; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Liver; PPAR alpha; Randomized Controlled Trials as Topic; Triglycerides	2006
Cardioprotective properties of fibrates: which fibrate, which patients, what mechanism? Circulation, 2006, Mar-28, Volume: 113, Issue:12 Topics: Cardiotonic Agents; Cardiovascular Diseases; Clofibric Acid; Coronary Disease; Gemfibrozil; Humans; Lipid Metabolism; Lipids	2006
Fibrates: what have we learned in the past 40 years? Pharmacotherapy, 2007, Volume: 27, Issue:3 Topics: Clinical Trials as Topic; Clofibric Acid; Coronary Disease; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Hypolipidemic Agents	2007
The clinical significance of the size of low-density-lipoproteins and the modulation of subclasses by fibrates. Current medical research and opinion, 2007, Volume: 23, Issue:5 Topics: Bezafibrate; Clofibric Acid; Dyslipidemias; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Lipoproteins, LDL; Particle Size; Treatment Outcome	2007
Does the addition of fibrates to statin therapy have a favorable risk to benefit ratio? Current atherosclerosis reports, 2008, Volume: 10, Issue:1 Topics: Atherosclerosis; Cardiovascular Diseases; Cholesterol, HDL; Clofibric Acid; Diabetic Angiopathies; Drug Therapy, Combination; Fenofibrate; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Randomized Controlled Trials as Topic; Rhabdomyolysis; Risk Assessment; Triglycerides	2008
Effect of fibrates on lipid profiles and cardiovascular outcomes: a systematic review. The American journal of medicine, 2009, Volume: 122, Issue:10 Topics: Anticholesteremic Agents; Bezafibrate; Cardiovascular Diseases; Cholesterol, LDL; Clofibric Acid; Female; Fenofibrate; Gemfibrozil; Humans; Hyperlipidemias; Prognosis; Randomized Controlled Trials as Topic; Risk Assessment; Survival Analysis; Treatment Outcome	2009
Fibrates for primary prevention of cardiovascular disease events. The Cochrane database of systematic reviews, 2016, 11-16, Volume: 11 Topics: Atorvastatin; Bezafibrate; Cardiovascular Diseases; Clofibric Acid; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Middle Aged; Myocardial Infarction; Primary Prevention; Simvastatin; Stroke	2016

Trials

9 trial(s) available for gemfibrozil and clofibric acid

Article	Year
Efficacy and tolerability of etofibrate and gemfibrozil in combined hyperlipidaemia. Drugs under experimental and clinical research, 1994, Volume: 20, Issue:3 Topics: Cholesterol; Cholesterol, HDL; Clofibric Acid; Female; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Single-Blind Method; Triglycerides	1994
Comparison of the efficacy of simvastatin and standard fibrate therapy in the treatment of primary hypercholesterolemia and combined hyperlipidemia. Clinical cardiology, 1995, Volume: 18, Issue:11 Topics: Anticholesteremic Agents; Bezafibrate; Cholesterol, LDL; Clofibric Acid; Fatty Acids, Volatile; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides	1995
Ciprofibrate versus gemfibrozil in the treatment of primary hyperlipidaemia. Atherosclerosis, 1996, Volume: 124 Suppl Topics: Adult; Aged; Clofibric Acid; Double-Blind Method; Female; Fibric Acids; Fibrinogen; Follow-Up Studies; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Retrospective Studies	1996
Modulation of plasma fibrinogen levels by ciprofibrate and gemfibrozil in primary hyperlipidaemia. Thrombosis and haemostasis, 1997, Volume: 77, Issue:1 Topics: Adult; Clofibric Acid; Female; Fibric Acids; Fibrinogen; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged	1997
Safety and efficacy of long-term statin-fibrate combinations in patients with refractory familial combined hyperlipidemia. The American journal of cardiology, 1997, Sep-01, Volume: 80, Issue:5 Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol, LDL; Clofibric Acid; Drug Therapy, Combination; Female; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Treatment Outcome	1997
Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients. Thrombosis and haemostasis, 1997, Volume: 78, Issue:4 Topics: Adult; Aged; Cholesterol; Clofibric Acid; Double-Blind Method; Female; Fibric Acids; Fibrinogen; Gemfibrozil; Humans; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Male; Middle Aged; Plasminogen Activator Inhibitor 1; Smoking; Tissue Plasminogen Activator; Treatment Outcome	1997
Statin-fibrate combinations in patients with combined hyperlipedemia. Atherosclerosis, 2001, Volume: 155, Issue:1 Topics: Clofibric Acid; Coronary Disease; Drug Therapy, Combination; Fibric Acids; Follow-Up Studies; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type V; Hypolipidemic Agents; Myocardial Infarction; Pravastatin; Simvastatin; Stroke	2001
Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: an open-label, multicenter study. Metabolism: clinical and experimental, 2001, Volume: 50, Issue:6 Topics: Adolescent; Adult; Aged; Apolipoproteins B; Body Weight; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Diet; Female; Fibric Acids; Fibrinogen; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Middle Aged; Triglycerides	2001
Atorvastatin versus four statin-fibrate combinations in patients with familial combined hyperlipidaemia. Journal of cardiovascular risk, 2002, Volume: 9, Issue:1 Topics: Adult; Aged; Atorvastatin; Clofibric Acid; Drug Therapy, Combination; Female; Fibric Acids; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemia, Familial Combined; Hypolipidemic Agents; Lipids; Male; Middle Aged; Pravastatin; Prospective Studies; Pyrroles; Simvastatin; Time Factors	2002

Other Studies

50 other study(ies) available for gemfibrozil and clofibric acid

Article	Year
Design, synthesis, and testing of potential antisickling agents. 10. (2,2-Dimethylchroman-6-yl)alkanoic acids. Journal of medicinal chemistry, 1987, Volume: 30, Issue:11 Topics: Antisickling Agents; Benzopyrans; Carboxylic Acids; Chromans; Hemoglobin, Sickle; Humans; Oxygen; Solubility; Structure-Activity Relationship	1987
Design, synthesis, and testing of potential antisickling agents. 4. Structure-activity relationships of benzyloxy and phenoxy acids. Journal of medicinal chemistry, 1984, Volume: 27, Issue:8 Topics: Acetates; Animals; Antisickling Agents; Benzyl Compounds; Binding Sites; Glycolates; Humans; Mice; Models, Molecular; Oxygen; Phenoxyacetates; Structure-Activity Relationship; X-Ray Diffraction	1984
Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3. Journal of medicinal chemistry, 2009, Nov-12, Volume: 52, Issue:21 Topics: 2,4-Dichlorophenoxyacetic Acid; Animals; Benzene Derivatives; Bezafibrate; Cell Line; Cercopithecidae; Clofibric Acid; Gemfibrozil; Herbicides; Humans; Hypolipidemic Agents; Indoleacetic Acids; Mice; Protein Subunits; Receptors, G-Protein-Coupled; Recombinant Fusion Proteins; Structure-Activity Relationship	2009
Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1 Topics: Anti-Inflammatory Agents, Non-Steroidal; Camphanes; Comet Assay; DNA Damage; Glucuronides; Glucuronosyltransferase; HEK293 Cells; Hepatocytes; Humans; Kidney	2011
Impact of Binding Site Comparisons on Medicinal Chemistry and Rational Molecular Design. Journal of medicinal chemistry, 2016, 05-12, Volume: 59, Issue:9 Topics: Binding Sites; Chemistry, Pharmaceutical; Drug Design; Models, Chemical; Proteins	2016
Druggability profile of stilbene-derived PPAR agonists: determination of physicochemical properties and PAMPA study. MedChemComm, 2019, Nov-01, Volume: 10, Issue:11 Topics:	2019
Differential inhibition of long-chain acyl-CoA hydrolases by hypolipidemic drugs in vitro. Biochemical pharmacology, 1992, Feb-04, Volume: 43, Issue:3 Topics: Animals; Bezafibrate; Clofibric Acid; Gemfibrozil; Hypolipidemic Agents; Liver; Male; Palmitoyl Coenzyme A; Palmitoyl-CoA Hydrolase; Rats; Rats, Inbred Strains; Subcellular Fractions	1992
In vitro effect of clofibric acid derivatives on rat hepatic microsomal electron transport chains. Biochemical pharmacology, 1991, Oct-24, Volume: 42, Issue:10 Topics: Animals; Bezafibrate; Clofibric Acid; Cytochromes b5; Electron Transport; Gemfibrozil; Kinetics; Male; Microsomes, Liver; NADH Dehydrogenase; NADPH Dehydrogenase; Rats; Rats, Inbred Strains	1991
Comparative studies on the influence of different fibrates on serum lipoproteins in endogenous hyperlipoproteinaemia. European journal of clinical pharmacology, 1991, Volume: 40, Issue:1 Topics: Adult; Aged; Bezafibrate; Cholesterol; Clofibrate; Clofibric Acid; Colestipol; Female; Fenofibrate; Gemfibrozil; Humans; Hyperlipoproteinemias; Hypolipidemic Agents; Lipoproteins; Male; Middle Aged; Probucol	1991
Quantitative assessment of enzyme induction by peroxisome proliferators and application to determination of effects on triglyceride biosynthesis in primary cultures of rat hepatocytes. Biochemical pharmacology, 1989, Dec-01, Volume: 38, Issue:23 Topics: Acyl-CoA Oxidase; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Induction; Fibric Acids; Gemfibrozil; Kinetics; Liver; Microbodies; Mixed Function Oxygenases; Oxidoreductases; Rats; Triglycerides	1989
Gemfibrozil increases both apo A-I and apo E concentrations. Comparison to other lipid regulators in cholesterol-fed rats. Atherosclerosis, 1986, Volume: 59, Issue:1 Topics: Animals; Apolipoprotein A-I; Apolipoproteins A; Apolipoproteins E; Bezafibrate; Cholesterol, Dietary; Cholesterol, HDL; Clofibrate; Clofibric Acid; Fenofibrate; Fibric Acids; Gemfibrozil; Male; Pentanoic Acids; Rats; Rats, Inbred Strains; Valerates	1986
Conditions influencing the induction of peroxisomal beta-oxidation in cultured rat hepatocytes. Toxicology letters, 1986, Volume: 30, Issue:2 Topics: Animals; Bezafibrate; Catalase; Cell Survival; Clofibric Acid; Fibric Acids; Gemfibrozil; In Vitro Techniques; Liver; Male; Microbodies; Pentanoic Acids; Rats; Rats, Inbred F344	1986
Effect of hypolipidemic drugs gemfibrozil, ciprofibrate, and clofibric acid on peroxisomal beta-oxidation in primary cultures of rainbow trout hepatocytes. Ecotoxicology and environmental safety, 1993, Volume: 26, Issue:2 Topics: 3-Hydroxyacyl CoA Dehydrogenases; Acyl-CoA Oxidase; Animals; Cells, Cultured; Clofibrate; Clofibric Acid; Cytochrome P-450 Enzyme System; Enoyl-CoA Hydratase; Enzyme Activation; Fibric Acids; Gemfibrozil; Hypolipidemic Agents; Isomerases; Liver; Male; Microbodies; Multienzyme Complexes; Oncorhynchus mykiss; Oxidation-Reduction; Oxidoreductases; Peroxisomal Bifunctional Enzyme	1993
Fibrates modify rat hepatic fatty acid chain elongation and desaturation in vitro. Biochemical pharmacology, 1993, Nov-17, Volume: 46, Issue:10 Topics: Acetyltransferases; Animals; Bezafibrate; Clofibric Acid; Cytosol; Fatty Acid Desaturases; Fatty Acid Elongases; Gemfibrozil; Liver; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley	1993
Cytosolic lipogenic enzymes: effect of fibric acid derivatives in vitro. Life sciences, 1993, Volume: 52, Issue:2 Topics: Animals; Bezafibrate; Clofibric Acid; Cytosol; Enzyme Inhibitors; Fatty Acids; Gemfibrozil; Kinetics; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley	1993
Fibrates induce mdr2 gene expression and biliary phospholipid secretion in the mouse. The Biochemical journal, 1996, Mar-15, Volume: 314 ( Pt 3) Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Bezafibrate; Bile; Bile Canaliculi; Clofibrate; Clofibric Acid; DNA Primers; Drug Resistance, Multiple; Fenofibrate; Fibric Acids; Gemfibrozil; Gene Expression; Hypolipidemic Agents; Liver; Male; Mice; Mice, Inbred Strains; Molecular Sequence Data; Multigene Family; Phospholipids; RNA, Messenger; RNA, Ribosomal, 18S	1996
Effect of chloride channel blockers on the cardiac CFTR chloride and L-type calcium currents. Cardiovascular research, 1996, Volume: 32, Issue:2 Topics: Animals; Anthracenes; Calcium; Calcium Channel Blockers; Chloride Channels; Chlorides; Clofibric Acid; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Fenofibrate; Gemfibrozil; Glycolates; Guinea Pigs; Ion Transport; Mice; Myocardium; ortho-Aminobenzoates; Patch-Clamp Techniques; Stilbenes	1996
Effects of initial BMI and on-treatment weight change on the lipid-lowering efficacy of fibrates. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1997, Volume: 21, Issue:2 Topics: Body Mass Index; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Lovastatin; Male; Middle Aged; Prospective Studies; Sex Factors; Simvastatin; Weight Loss	1997
Effects of gemfibrozil and clofibric acid on the uptake of taurocholate by isolated rat hepatocytes. Biochemical pharmacology, 1997, Jul-01, Volume: 54, Issue:1 Topics: Animals; Biological Transport; Cells, Cultured; Clofibric Acid; Gemfibrozil; Hypolipidemic Agents; Kinetics; Liver; Rats; Taurocholic Acid	1997
Genotoxicity of acyl glucuronide metabolites formed from clofibric acid and gemfibrozil: a novel role for phase-II-mediated bioactivation in the hepatocarcinogenicity of the parent aglycones? Toxicology and applied pharmacology, 1997, Volume: 147, Issue:2 Topics: Clofibric Acid; DNA, Single-Stranded; Escherichia coli; Gemfibrozil; Glucuronates; Mutagenicity Tests; Mutagens; Plasmids; SOS Response, Genetics	1997
No effect of fibrates on synthesis of apolipoprotein(a) in primary cultures of cynomolgus monkey and human hepatocytes: apolipoprotein A-I synthesis increased. Biochemical and biophysical research communications, 1998, Mar-17, Volume: 244, Issue:2 Topics: Animals; Apolipoprotein A-I; Apolipoproteins A; Bezafibrate; Cells, Cultured; Clofibrate; Clofibric Acid; Gemfibrozil; Humans; Liver; Macaca fascicularis	1998
Comparison of the effects of gemfibrozil and clofibric acid on peroxisomal enzymes and cholesterol synthesis of rat hepatocytes. Biological & pharmaceutical bulletin, 1998, Volume: 21, Issue:11 Topics: Animals; Cells, Cultured; Cholesterol; Clofibric Acid; Enzyme Induction; Gemfibrozil; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Hypolipidemic Agents; Liver; Male; Microbodies; Peroxisome Proliferators; Rats; Rats, Wistar	1998
Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -- role of the peroxisome proliferator-activated receptor-alpha. Thrombosis and haemostasis, 1998, Volume: 80, Issue:6 Topics: 5,8,11,14-Eicosatetraynoic Acid; Alitretinoin; Animals; Apolipoprotein A-I; Cells, Cultured; Clofibrate; Clofibric Acid; Dimerization; Female; Fenofibrate; Fibric Acids; Fibrinogen; Gemfibrozil; Gene Expression Regulation; Genes, Reporter; Hypolipidemic Agents; Liver; Macaca fascicularis; Male; Peroxisome Proliferators; Plasminogen Activator Inhibitor 1; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Transcription Factors; Transcriptional Activation; Tretinoin	1998
The effect of peroxisome proliferators on mitochondrial bioenergetics. Toxicological sciences : an official journal of the Society of Toxicology, 1999, Volume: 48, Issue:1 Topics: Animals; Bezafibrate; Calcium; Clofibrate; Clofibric Acid; Diethylhexyl Phthalate; Energy Metabolism; Fenofibrate; Fibric Acids; Gemfibrozil; Intracellular Membranes; Male; Membrane Potentials; Mitochondria, Liver; Mitochondrial Swelling; Oxygen; Permeability; Peroxisome Proliferators; Pyrimidines; Rats; Rats, Sprague-Dawley; Trichloroethylene	1999
Effects of fibrate compounds on expression of plasminogen activator inhibitor-1 by cultured endothelial cells. Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:6 Topics: Bezafibrate; Cells, Cultured; Clofibric Acid; Endothelium, Vascular; Fenofibrate; Gemfibrozil; Humans; Hypolipidemic Agents; Plasminogen Activator Inhibitor 1; Pyrimidines; RNA, Messenger; Rosiglitazone; Thiazoles; Thiazolidinediones; Transcription, Genetic	1999
Bezafibrate as differentiating factor of human myeloid leukemia cells. Cell death and differentiation, 1999, Volume: 6, Issue:8 Topics: Acetylcysteine; Antineoplastic Agents; Antioxidants; Bezafibrate; Biomarkers; Cell Cycle; Cell Differentiation; Clofibric Acid; Gemfibrozil; Growth Inhibitors; HL-60 Cells; Humans; Integrin alphaXbeta2; K562 Cells; Leukemia, Myeloid; Lipopolysaccharide Receptors; U937 Cells	1999
Changes in isoprenoid lipid synthesis by gemfibrozil and clofibric acid in rat hepatocytes. Biochemical pharmacology, 2000, May-15, Volume: 59, Issue:10 Topics: Acetates; Acyl Coenzyme A; Animals; Cholesterol; Clofibric Acid; Dolichols; Gemfibrozil; Hydroxymethylglutaryl CoA Reductases; Hypolipidemic Agents; Lipid Metabolism; Lipids; Liver; Male; Mevalonic Acid; Peroxisomes; Rats; Ubiquinone	2000
Hepatic disposition of the acyl glucuronide 1-O-gemfibrozil-beta-D-glucuronide: effects of clofibric acid, acetaminophen, and acetaminophen glucuronide. The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:1 Topics: Acetaminophen; Animals; Biological Transport; Clofibric Acid; Gemfibrozil; Glucuronates; Liver; Male; Perfusion; Rats; Rats, Sprague-Dawley	2000
Fibrate-induced increase in blood urea and creatinine: is gemfibrozil the only innocuous agent? Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2000, Volume: 15, Issue:12 Topics: Bezafibrate; Clofibric Acid; Creatinine; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Kidney Diseases; Kidney Transplantation; Postoperative Period; Retrospective Studies; Urea	2000
Fibrate treatment can increase serum creatinine levels. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2001, Volume: 16, Issue:6 Topics: Clofibric Acid; Creatinine; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Kidney Diseases; Urea	2001
Ciprofibrate versus gemfibrozil in the treatment of mixed hyperlipidemias: an open-label, multicenter study. Metabolism: clinical and experimental, 2001, Volume: 50, Issue:11 Topics: Clofibric Acid; Fibric Acids; Gemfibrozil; Humans; Hyperlipoproteinemia Type V; Hypolipidemic Agents; Lipoproteins, LDL; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Treatment Outcome	2001
Detection of pharmaceutical contaminations of river, pond, and tap water from Cologne (Germany) and surroundings. International journal of hygiene and environmental health, 2002, Volume: 205, Issue:5 Topics: Anti-Inflammatory Agents, Non-Steroidal; Clofibric Acid; Environmental Monitoring; Gas Chromatography-Mass Spectrometry; Gemfibrozil; Germany; Humans; Ibuprofen; Pharmaceutical Preparations; Water Pollutants, Chemical; Water Supply	2002
Effects of various fibrates on serum alkaline phosphatase activity. Atherosclerosis, 2002, Volume: 165, Issue:1 Topics: Alkaline Phosphatase; Bezafibrate; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hyperlipidemias; Hypolipidemic Agents; Male; Retrospective Studies; Treatment Outcome	2002
Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells. Naunyn-Schmiedeberg's archives of pharmacology, 2003, Volume: 367, Issue:3 Topics: Bezafibrate; Clofibrate; Clofibric Acid; Disease Models, Animal; Drug Synergism; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypolipidemic Agents; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Rhabdomyosarcoma, Embryonal; RNA, Messenger; Simvastatin; Time Factors; Transcription Factors; Tumor Cells, Cultured	2003
PPARalpha agonists stimulate progastrin production in human colorectal carcinoma cells. Regulatory peptides, 2004, Aug-15, Volume: 120, Issue:1-3 Topics: Bezafibrate; Cell Proliferation; Clofibrate; Clofibric Acid; Colorectal Neoplasms; Fenofibrate; Fibric Acids; Gastrins; Gemfibrozil; Humans; Hypolipidemic Agents; Ligands; Peroxisome Proliferator-Activated Receptors; Protein Precursors; Pyrimidines; Radioimmunoassay; RNA, Messenger; Rosiglitazone; Thiazolidinediones; Vasodilator Agents	2004
Mitochondrial respiratory chain dysfunction, a non-receptor-mediated effect of synthetic PPAR-ligands: biochemical and pharmacological implications. Biochemical and biophysical research communications, 2004, Jul-02, Volume: 319, Issue:3 Topics: Bezafibrate; Cell Differentiation; Cell Division; Clofibric Acid; Dose-Response Relationship, Drug; Electron Transport; Gemfibrozil; HL-60 Cells; Humans; Hypoglycemic Agents; Hypolipidemic Agents; Ligands; Mitochondria; Receptors, Cytoplasmic and Nuclear; Thiazolidinediones; Transcription Factors	2004
Co-induction of methyltransferase Rv0560c by naphthoquinones and fibric acids suggests attenuation of isoprenoid quinone action in Mycobacterium tuberculosis. Canadian journal of microbiology, 2004, Volume: 50, Issue:10 Topics: Amino Acid Motifs; Amino Acid Sequence; Bacillus megaterium; Bacterial Proteins; Cell Membrane; Clofibric Acid; Conserved Sequence; Electrophoresis, Gel, Two-Dimensional; Enzyme Activators; Gemfibrozil; Gene Expression Regulation, Bacterial; Genes, Bacterial; Methyltransferases; Molecular Sequence Data; Molecular Weight; Mycobacterium tuberculosis; Naphthoquinones; Sequence Homology, Amino Acid	2004
High-density lipoprotein cholesterol: ready for prime time? Singapore medical journal, 2005, Volume: 46, Issue:10 Topics: Cardiovascular Diseases; Carrier Proteins; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Cholesterol, LDL; Clofibric Acid; Diabetes Mellitus; Gemfibrozil; Glycoproteins; Humans; Mutation; Risk Factors	2005
Differential associations of statin and fibrate treatment with carotid arterial remodeling. American journal of hypertension, 2005, Volume: 18, Issue:11 Topics: Adult; Atorvastatin; Bezafibrate; Body Mass Index; Carotid Arteries; Cholesterol, HDL; Clofibric Acid; Cohort Studies; Dyslipidemias; Fatty Acids, Monounsaturated; Female; Fenofibrate; Fibric Acids; Fluvastatin; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Indoles; Male; Middle Aged; Multivariate Analysis; Pravastatin; Pyridines; Pyrroles; Risk Factors; Simvastatin; Treatment Outcome; Tunica Intima; Tunica Media; Ultrasonography	2005
[Drug combinations: statins and fibrates]. Arquivos brasileiros de cardiologia, 2005, Volume: 85 Suppl 5 Topics: Age Factors; Clofibric Acid; Drug Interactions; Drug Therapy, Combination; Dyslipidemias; Female; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertriglyceridemia; Male; Myositis; Rhabdomyolysis; Sex Factors	2005
Separation of fibrate-type antihyperlipidemic drugs by capillary electrophoresis and their quantitation in pharmaceuticals. Journal of pharmaceutical and biomedical analysis, 2006, May-03, Volume: 41, Issue:2 Topics: Bezafibrate; Buffers; Clofibric Acid; Electrophoresis, Capillary; Fibric Acids; Gemfibrozil; Hydrogen-Ion Concentration; Hypolipidemic Agents; Pharmaceutical Preparations; Reproducibility of Results; Temperature; Time Factors	2006
The interference of pharmaceuticals with endogenous and xenobiotic metabolizing enzymes in carp liver: an in-vitro study. Environmental science & technology, 2006, Aug-15, Volume: 40, Issue:16 Topics: Animals; Antidepressive Agents; Carps; Catalysis; Clofibric Acid; Diclofenac; Gemfibrozil; Lipids; Liver; Liver Extracts; Pharmaceutical Preparations; Subcellular Fractions; Sulfotransferases; Xenobiotics	2006
Removal of selected pharmaceuticals by chlorination, coagulation-sedimentation and powdered activated carbon treatment. Water science and technology : a journal of the International Association on Water Pollution Research, 2008, Volume: 58, Issue:5 Topics: Antipyrine; Charcoal; Clofibric Acid; Diclofenac; Fenoprofen; Gemfibrozil; Halogenation; Ibuprofen; Indomethacin; Ketoprofen; Naproxen; Water Pollutants, Chemical; Water Purification; Water Supply	2008
Gemfibrozil inhibits Legionella pneumophila and Mycobacterium tuberculosis enoyl coenzyme A reductases and blocks intracellular growth of these bacteria in macrophages. Journal of bacteriology, 2009, Volume: 191, Issue:16 Topics: Acyl-CoA Dehydrogenases; Amino Acid Sequence; Animals; Cells, Cultured; Clofibric Acid; Enzyme Activation; Escherichia coli; Gemfibrozil; Glyceraldehyde; Humans; Kinetics; Legionella pneumophila; Lipid Metabolism; Macrophages; Mice; Microbial Sensitivity Tests; Microscopy, Electron, Transmission; Molecular Sequence Data; Mycobacterium tuberculosis; Propane; Sequence Homology, Amino Acid	2009
Effects of WY-14643 on peroxisomal enzyme activity and hormone secretion in immortalized human trophoblast cells. Biological & pharmaceutical bulletin, 2009, Volume: 32, Issue:7 Topics: Acyl-CoA Oxidase; Catalase; Cell Culture Techniques; Cell Line; Centrifugation, Density Gradient; Chorionic Gonadotropin; Clofibric Acid; Gemfibrozil; Hormones; Humans; Peroxisome Proliferators; Peroxisomes; Progesterone; Pyrimidines; Trophoblasts	2009
Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study. Marine pollution bulletin, 2011, Volume: 62, Issue:10 Topics: Androgens; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Biomarkers; Carps; Clofibrate; Clofibric Acid; Diclofenac; Fibric Acids; Fluoxetine; Gemfibrozil; Ibuprofen; Male; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Testis; Water Pollutants, Chemical	2011
Distribution and temporal evolution of pharmaceutically active compounds alongside sewage sludge treatment. Risk assessment of sludge application onto soils. Journal of environmental management, 2012, Jul-15, Volume: 102 Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Caffeine; Carbamazepine; Clofibric Acid; Environmental Pollutants; Environmental Pollution; Estradiol; Gemfibrozil; Propranolol; Risk Assessment; Sewage; Soil; Spain; Time Factors	2012
The role of microbial adaptation and biodegradable dissolved organic carbon on the attenuation of trace organic chemicals during groundwater recharge. The Science of the total environment, 2012, Oct-15, Volume: 437 Topics: 2-Methyl-4-chlorophenoxyacetic Acid; 2,4-Dichlorophenoxyacetic Acid; Adaptation, Physiological; Biodegradation, Environmental; Carbon; Clofibric Acid; Gemfibrozil; Groundwater; Ibuprofen; Ketoprofen; Naproxen; Organic Chemicals; Soil Microbiology; Water Microbiology; Water Pollutants, Chemical; Water Purification	2012
Clofibric acid and gemfibrozil removal in membrane bioreactors. Water science and technology : a journal of the International Association on Water Pollution Research, 2015, Volume: 71, Issue:8 Topics: Biomass; Bioreactors; Clofibric Acid; Gemfibrozil; Hypolipidemic Agents; Membranes, Artificial; Sewage; Ultrafiltration; Waste Disposal, Fluid; Water Pollutants, Chemical	2015
Degradation of lipid regulators by the UV/chlorine process: Radical mechanisms, chlorine oxide radical (ClO Water research, 2018, 06-15, Volume: 137 Topics: Ammonia; Bezafibrate; Chlorine; Chlorine Compounds; Clofibric Acid; Disinfection; Gemfibrozil; Halogenation; Hydroxyl Radical; Hypolipidemic Agents; Kinetics; Oxidation-Reduction; Photolysis; Ultraviolet Rays; Vibrio; Waste Disposal, Fluid; Water Pollutants, Chemical; Water Purification	2018