Compounds > gemcitabine
Page last updated: 2024-08-24

gemcitabine and triphosphoric acid

gemcitabine has been researched along with triphosphoric acid in 6 studies

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's3 (50.00)29.6817
2010's1 (16.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Bergman, AM; Brouwer, M; Eriksson, S; Jongsma, AP; Leyva, A; Peters, GJ; Pinedo, HM; Ruiz van Haperen, VW; Veerman, G1
Bendele, RA; Kuchta, RD; Moore, CL; Richardson, FC; Richardson, KA; Rohloff, JC; Tomkinson, B; Vega, TP1
Chadda, SK; Hossain, MT; Kane, CT; Risbood, PA; Vadapalli, S1
Galmarini, CM; Kohli, E; Mitin, A; Vinogradov, SV; Warren, G; Zeman, A1
Hodge, LS; Taub, ME; Tracy, TS1
Bearne, SL; Gillis, TD; Holyoak, T; McCluskey, GD; McLeod, MJ; Tran, N1

Other Studies

6 other study(ies) available for gemcitabine and triphosphoric acid

ArticleYear
Decreased resistance to gemcitabine (2',2'-difluorodeoxycitidine) of cytosine arabinoside-resistant myeloblastic murine and rat leukemia cell lines: role of altered activity and substrate specificity of deoxycytidine kinase.
    Biochemical pharmacology, 1999, Feb-15, Volume: 57, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cytarabine; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; DNA; Drug Resistance; Gemcitabine; Leukemia L1210; Mice; Nucleoside Deaminases; Polyphosphates; Rats; Rats, Inbred BN; Substrate Specificity; Thymidine Kinase; Tumor Cells, Cultured

1999
Polymerization of the triphosphates of AraC, 2',2'-difluorodeoxycytidine (dFdC) and OSI-7836 (T-araC) by human DNA polymerase alpha and DNA primase.
    Biochemical pharmacology, 2004, Dec-15, Volume: 68, Issue:12

    Topics: Arabinonucleosides; Cytarabine; Deoxycytidine; DNA Polymerase I; DNA Primase; Gemcitabine; Humans; Polymers; Polyphosphates

2004
Synthesis of gemcitabine triphosphate (dFdCTP) as a tris(triethylammonium) salt.
    Bioorganic & medicinal chemistry letters, 2008, May-01, Volume: 18, Issue:9

    Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Deoxycytidine; Gemcitabine; Humans; Models, Chemical; Polyphosphates; Quaternary Ammonium Compounds; Salts; Tromethamine; Tumor Cells, Cultured

2008
Polymeric nanogels containing the triphosphate form of cytotoxic nucleoside analogues show antitumor activity against breast and colorectal cancer cell lines.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:10

    Topics: Animals; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Breast Neoplasms; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Colorectal Neoplasms; Cytarabine; Deoxycytidine; Drug Carriers; Drug Screening Assays, Antitumor; Flow Cytometry; Gemcitabine; Humans; Mice; Nanogels; Nucleosides; Polyethylene Glycols; Polyethyleneimine; Polymers; Polyphosphates

2008
The deaminated metabolite of gemcitabine, 2',2'-difluorodeoxyuridine, modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine kinase.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:11

    Topics: Antineoplastic Agents; Biological Transport; Deamination; Deoxycytidine; Deoxycytidine Kinase; Floxuridine; Gemcitabine; HeLa Cells; Humans; Inactivation, Metabolic; Phosphorylation; Polyphosphates; RNA, Small Interfering; Tumor Cells, Cultured

2011
A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
    Protein science : a publication of the Protein Society, 2023, Volume: 32, Issue:6

    Topics: Adenosine Triphosphate; Carbon-Nitrogen Ligases; Escherichia coli; Gemcitabine; Kinetics; Nucleotides

2023