Compounds > gemcitabine
Page last updated: 2024-08-24

gemcitabine and trichostatin a

gemcitabine has been researched along with trichostatin a in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's6 (54.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, X; Qiu, W; Shih, J; Xue, L; Yen, Y; Zheng, S; Zhou, B1
Ogretmen, B; Wooten, LG1
Hirakawa, K; Ren, J; Yashiro, M; Zhang, X1
Beghelli, S; Bonora, A; Budillon, A; Caraglia, M; Costanzo, C; Dandrea, M; Donadelli, M; Palmieri, M; Piacentini, P; Scarpa, A; Scupoli, MT1
Gahr, S; Ganslmayer, M; Hahn, EG; Hartl, A; Herold, C; Leitner, S; Ocker, M; Okamoto, K; Zopf, S1
Byun, SS; Hong, SK; Jeon, HG; Jeong, SJ; Lee, JE; Lee, SE; Park, MJ; Yoon, CY; Yu, JH1
Cogdill, AP; Cooper, ZA; Ferrone, CR; Fiedler, A; Frederick, DT; Garber, HR; Rosenberg, L; Thayer, SP; Wargo, JA; Warshaw, AL1
Hour, TC; Huang, CN; Huang, HS; Kang, WY; Li, CC; Li, WM; Liu, ZM; Wu, WJ; Yeh, BW1
Cai, MH; Sun, Z; Tu, YX; Wang, BK; Xu, XG; Yan, SL; Ying, Y1
Ji, M; Lee, EJ; Park, SM; Wang, JH1
Chang, HC; Chow, PM; Hong, JY; Hsu, FS; Huang, KH; Kuo, KL; Kuo, Y; Liao, SM; Lin, MC; Lin, WC; Liu, SH; Shi, CS; Shun, CT; Tsai, YC; Wu, JT; Yang, SP1

Other Studies

11 other study(ies) available for gemcitabine and trichostatin a

ArticleYear
Nuclear factor Y regulation and promoter transactivation of human ribonucleotide reductase subunit M2 gene in a Gemcitabine resistant KB clone.
    Biochemical pharmacology, 2004, Apr-15, Volume: 67, Issue:8

    Topics: Antimetabolites, Antineoplastic; Biological Transport; CCAAT-Binding Factor; CCAAT-Enhancer-Binding Proteins; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression; Humans; Hydroxamic Acids; KB Cells; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Ribonucleoside Diphosphate Reductase; Transcription Factors; Transcriptional Activation

2004
Sp1/Sp3-dependent regulation of human telomerase reverse transcriptase promoter activity by the bioactive sphingolipid ceramide.
    The Journal of biological chemistry, 2005, Aug-12, Volume: 280, Issue:32

    Topics: Base Sequence; Cell Line, Tumor; Ceramides; Chromatin Immunoprecipitation; Chromatography, High Pressure Liquid; Deoxycytidine; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Gemcitabine; Histone Deacetylases; Humans; Hydroxamic Acids; Immunoblotting; Immunoprecipitation; Luciferases; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Promoter Regions, Genetic; Protein Structure, Tertiary; Protein Synthesis Inhibitors; RNA Polymerase II; RNA, Small Interfering; Sp1 Transcription Factor; Sp3 Transcription Factor; Sphingolipids; Telomerase; Transcription Factors; Transfection

2005
Histone deacetylase inhibitor, trichostatin A, increases the chemosensitivity of anticancer drugs in gastric cancer cell lines.
    Oncology reports, 2006, Volume: 16, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Camptothecin; Cell Proliferation; Deoxycytidine; Drug Resistance, Neoplasm; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Fluorouracil; Gemcitabine; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Stomach Neoplasms; Tumor Cells, Cultured

2006
Synergistic inhibition of pancreatic adenocarcinoma cell growth by trichostatin A and gemcitabine.
    Biochimica et biophysica acta, 2007, Volume: 1773, Issue:7

    Topics: 5'-Nucleotidase; Adenocarcinoma; Animals; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Enzyme Inhibitors; Gemcitabine; Glycoproteins; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Membrane Proteins; Mice; Pancreatic Neoplasms; Proto-Oncogene Proteins; Reactive Oxygen Species

2007
The combination of the histone-deacetylase inhibitor trichostatin A and gemcitabine induces inhibition of proliferation and increased apoptosis in pancreatic carcinoma cells.
    International journal of oncology, 2007, Volume: 31, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; bcl-2-Associated X Protein; Carcinoma; Caspase 3; Caspase 8; Cell Line, Tumor; Cell Proliferation; Cell Separation; Deoxycytidine; Flow Cytometry; Gemcitabine; Humans; Hydroxamic Acids; Pancreatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins p21(ras)

2007
Induction of caspase mediated apoptosis and down-regulation of nuclear factor-κB and Akt signaling are involved in the synergistic antitumor effect of gemcitabine and the histone deacetylase inhibitor trichostatin A in human bladder cancer cells.
    The Journal of urology, 2011, Volume: 186, Issue:5

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Caspases; Cell Cycle Checkpoints; Cell Line, Tumor; Deoxycytidine; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; Drug Therapy, Combination; Gemcitabine; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; NF-kappa B; Proto-Oncogene Proteins c-akt; Signal Transduction; Urinary Bladder Neoplasms

2011
Targeting the MAGE A3 antigen in pancreatic cancer.
    Surgery, 2012, Volume: 152, Issue:3 Suppl 1

    Topics: Adenocarcinoma; Antigens, Neoplasm; Azacitidine; Cell Line, Tumor; Chromatin Assembly and Disassembly; Cytokines; Decitabine; Deoxycytidine; DNA Methylation; Gemcitabine; Humans; Hydroxamic Acids; Immunotherapy; Male; Neoplasm Proteins; Pancreas; Pancreatic Neoplasms; Receptors, Antigen, T-Cell; T-Lymphocytes; Testis; Valproic Acid

2012
Histone deacetylase inhibitor trichostatin A resensitizes gemcitabine resistant urothelial carcinoma cells via suppression of TG-interacting factor.
    Toxicology and applied pharmacology, 2016, Jan-01, Volume: 290

    Topics: Aged; Deoxycytidine; Down-Regulation; Drug Resistance, Neoplasm; Female; Gemcitabine; Histone Deacetylase Inhibitors; Homeodomain Proteins; Humans; Hydroxamic Acids; Male; Proto-Oncogene Proteins c-akt; Repressor Proteins; Tumor Cells, Cultured; Urinary Bladder Neoplasms

2016
Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine.
    Scientific reports, 2018, 01-26, Volume: 8, Issue:1

    Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Deoxycytidine; Gemcitabine; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Neoplastic Stem Cells; Pancreatic Neoplasms

2018
HDAC inhibitors, trichostatin A and valproic acid, increase E‑cadherin and vimentin expression but inhibit migration and invasion of cholangiocarcinoma cells.
    Oncology reports, 2018, Volume: 40, Issue:1

    Topics: Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cholangiocarcinoma; Deoxycytidine; Epithelial-Mesenchymal Transition; Gemcitabine; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Neoplasm Invasiveness; Valproic Acid; Vimentin

2018
Trichostatin A, a histone deacetylase inhibitor, induces synergistic cytotoxicity with chemotherapy via suppression of Raf/MEK/ERK pathway in urothelial carcinoma.
    Journal of molecular medicine (Berlin, Germany), 2018, Volume: 96, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Cisplatin; Deoxycytidine; Doxorubicin; Drug Synergism; Gemcitabine; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; MAP Kinase Signaling System; Mice, Nude; Protein Kinase Inhibitors; Protein Kinases; RNA, Small Interfering; Urologic Neoplasms

2018