Page last updated: 2024-08-24

gemcitabine and thioinosine

gemcitabine has been researched along with thioinosine in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (25.00)18.2507
2000's3 (37.50)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Burke, T; Ferguson, PJ; Hammond, JR; Lee, S1
Belt, JA; Cass, CE; Crawford, CR; Mackey, JR; Mani, RS; Mowles, D; Selner, M; Young, JD1
Achiwa, H; Maeda, H; Niimi, T; Oguri, T; Sato, S; Ueda, R1
Ahmad, I; Ahmad, MU; Ali, SM; Chen, P; Chien, PY; Khan, AR; Sheikh, S1
Curigliano, G; Danesi, R; De Braud, F; De Cobelli, O; Del Tacca, M; Giovannetti, E; Mey, V; Nannizzi, S; Pece, S; Verweij, F1
Barron, G; Cass, CE; Damaraju, VL; Mowles, D; Peng, Y; Robins, MJ; Tackaberry, T; Young, JD1
Kitagawa, H; Miyamoto, K; Nakanishi, T; Ohta, T; Sai, Y; Sawamoto, K; Shimada, T; Tajima, H; Takabayashi, M; Tamai, I; Yamazaki, M; Yokono, R1
Coe, IR; Naydenova, Z; Zafar, M1

Trials

1 trial(s) available for gemcitabine and thioinosine

ArticleYear
In vitro synergistic cytotoxicity of gemcitabine and pemetrexed and pharmacogenetic evaluation of response to gemcitabine in bladder cancer patients.
    British journal of cancer, 2006, Aug-07, Volume: 95, Issue:3

    Topics: Administration, Intravesical; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Deoxycytidine Kinase; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Equilibrative Nucleoside Transporter 1; Excitatory Amino Acid Antagonists; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Glutamates; Guanine; Humans; Male; Middle Aged; Neoplasm Staging; Pemetrexed; Phosphoribosylglycinamide Formyltransferase; Phosphorylation; Proto-Oncogene Proteins c-akt; S Phase; Thioinosine; Thymidylate Synthase; Treatment Outcome; Urinary Bladder Neoplasms

2006

Other Studies

7 other study(ies) available for gemcitabine and thioinosine

ArticleYear
Interaction of 2',2'-difluorodeoxycytidine (gemcitabine) and formycin B with the Na+-dependent and -independent nucleoside transporters of Ehrlich ascites tumor cells.
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Ehrlich Tumor; Carrier Proteins; Deoxycytidine; Formycins; Gemcitabine; Male; Membrane Proteins; Mice; Nucleoside Transport Proteins; Sodium; Thioinosine; Uridine

1998
Functional nucleoside transporters are required for gemcitabine influx and manifestation of toxicity in cancer cell lines.
    Cancer research, 1998, Oct-01, Volume: 58, Issue:19

    Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Cell Survival; Deoxycytidine; Dipyridamole; DNA, Complementary; Gemcitabine; HeLa Cells; Humans; K562 Cells; Kinetics; Membrane Proteins; Membrane Transport Proteins; Nucleoside Transport Proteins; Recombinant Proteins; Thioinosine; Transfection; Tumor Cells, Cultured

1998
Determinants of sensitivity and resistance to gemcitabine: the roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non-small cell lung cancer.
    Cancer science, 2004, Volume: 95, Issue:9

    Topics: Affinity Labels; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Division; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Gemcitabine; Humans; Lung Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Thioinosine; Tumor Cells, Cultured

2004
In-vitro and in-vivo anti-cancer activity of a novel gemcitabine-cardiolipin conjugate.
    Anti-cancer drugs, 2006, Volume: 17, Issue:1

    Topics: Animals; Antineoplastic Agents; Body Weight; Cardiolipins; Cell Proliferation; Deoxycytidine; Dipyridamole; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Gemcitabine; HT29 Cells; Humans; Leukemia P388; Leukocyte Count; Mice; Mice, SCID; Neutropenia; Nucleoside Transport Proteins; Pancreatic Neoplasms; Thioinosine; Xenograft Model Antitumor Assays

2006
Improved syntheses of 5'-S-(2-aminoethyl)-6-N-(4-nitrobenzyl)-5'-thioadenosine (SAENTA), analogues, and fluorescent probe conjugates: analysis of cell-surface human equilibrative nucleoside transporter 1 (hENT1) levels for prediction of the antitumor effi
    Journal of medicinal chemistry, 2010, Aug-26, Volume: 53, Issue:16

    Topics: Adenosine; Animals; Antineoplastic Agents; Cell Line, Tumor; Deoxycytidine; Equilibrative Nucleoside Transporter 1; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Gemcitabine; Humans; Mice; Oocytes; Protein Binding; Stereoisomerism; Structure-Activity Relationship; Thioinosine; Thionucleosides; Xenopus; Yeasts

2010
Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:9

    Topics: Animals; Binding Sites; Biological Transport; Carrier Proteins; Cell Membrane; Deoxycytidine; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Female; Gemcitabine; Hepatic Artery; Hepatocytes; Humans; Infusion Pumps; Male; Membrane Proteins; Middle Aged; Rats; Rats, Wistar; Thioinosine

2015
Extended exposure to substrate regulates the human equilibrative nucleoside transporter 1 (hENT1).
    Nucleosides, nucleotides & nucleic acids, 2016, Volume: 35, Issue:10-12

    Topics: Antimetabolites, Antineoplastic; Binding Sites; Cytidine; Deoxycytidine; Equilibrative Nucleoside Transporter 1; Gemcitabine; HEK293 Cells; Humans; Protein Transport; Thioinosine

2016