Compounds > gemcitabine
Page last updated: 2024-08-24

gemcitabine and tetrahydrouridine

gemcitabine has been researched along with tetrahydrouridine in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (33.33)18.2507
2000's1 (11.11)29.6817
2010's5 (55.56)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Degen, D; Grindey, GB; Hanauske, AR; Hilsenbeck, SG; Marshall, MH; Von Hoff, DD1
Bouffard, DY; Laliberté, J; Momparler, RL1
Cournoyer, D; Eliopoulos, N; Momparler, RL1
Beumer, JH; Covey, JM; Egorin, MJ; Eiseman, JL; Joseph, E; Parise, RA1
Funamizu, N; Gocho, T; Kamata, Y; Manome, Y; Misawa, T; Okamoto, A; Uwagawa, T; Yanaga, K1
Ames, MM; Bai, L; Beumer, JH; Clausen, DM; Covey, JM; D'Argenio, DZ; Egorin, MJ; Eiseman, JL; Gilbert, JA; Hershberger, PA; Holleran, JL; Parise, RA; Yellow-Duke, AE1
Fujita, K; Funamizu, N; Furukawa, K; Lacy, CR; Manome, Y; Misawa, T; Yanaga, K1
Balzarini, J; Fieuws, S; Hofer, A; Liekens, S; Noppen, S; Ranjbarian, F; Sabuncuoğlu, S; Vande Voorde, J1
Hotta, K; Ishii, T; Kita, K; Kusano, K; Mano, Y; Sakamaki, K; Ueno, T1

Other Studies

9 other study(ies) available for gemcitabine and tetrahydrouridine

ArticleYear
Activity of 2',2'-difluorodeoxycytidine (Gemcitabine) against human tumor colony forming units.
    Anti-cancer drugs, 1992, Volume: 3, Issue:2

    Topics: Antimetabolites, Antineoplastic; Deamination; Deoxycytidine; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Neoplasms, Experimental; Tetrahydrouridine; Tumor Cells, Cultured; Tumor Stem Cell Assay

1992
Kinetic studies on 2',2'-difluorodeoxycytidine (Gemcitabine) with purified human deoxycytidine kinase and cytidine deaminase.
    Biochemical pharmacology, 1993, May-05, Volume: 45, Issue:9

    Topics: Antimetabolites, Antineoplastic; Azepines; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Deoxycytosine Nucleotides; Gemcitabine; Half-Life; Humans; Kinetics; Tetrahydrouridine

1993
Drug resistance to 5-aza-2'-deoxycytidine, 2',2'-difluorodeoxycytidine, and cytosine arabinoside conferred by retroviral-mediated transfer of human cytidine deaminase cDNA into murine cells.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:5

    Topics: 3T3 Cells; Animals; Antimetabolites; Antimetabolites, Antineoplastic; Azacitidine; Colony-Forming Units Assay; Cytarabine; Cytidine Deaminase; Decitabine; Deoxycytidine; DNA, Complementary; Drug Resistance; Enzyme Inhibitors; Fibroblasts; Gemcitabine; Gene Transfer Techniques; Genetic Vectors; Humans; Mice; Phenotype; Retroviridae; Tetrahydrouridine

1998
Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jun-01, Volume: 14, Issue:11

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Biological Availability; Deoxycytidine; Drug Interactions; Gemcitabine; Male; Mice; Tetrahydrouridine

2008
Is the resistance of gemcitabine for pancreatic cancer settled only by overexpression of deoxycytidine kinase?
    Oncology reports, 2010, Volume: 23, Issue:2

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Models, Biological; Nucleoside Deaminases; Pancreatic Neoplasms; Tetrahydrouridine; Transfection; Up-Regulation

2010
Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:2

    Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Biocatalysis; Biological Availability; Blood; Cytidine Deaminase; Deoxycytidine; Gemcitabine; Humans; Injections, Intravenous; Male; Mice; Mice, Inbred Strains; Models, Biological; Prodrugs; Recombinant Proteins; Specific Pathogen-Free Organisms; Tetrahydrouridine; Urine

2011
Tetrahydrouridine inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels.
    PloS one, 2012, Volume: 7, Issue:5

    Topics: Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cytidine Deaminase; Deoxycytidine; Enzyme Inhibitors; Gemcitabine; Humans; Lung Neoplasms; Pancreatic Neoplasms; Tetrahydrouridine

2012
Nucleoside-catabolizing enzymes in mycoplasma-infected tumor cell cultures compromise the cytostatic activity of the anticancer drug gemcitabine.
    The Journal of biological chemistry, 2014, May-09, Volume: 289, Issue:19

    Topics: Animals; Antimetabolites, Antineoplastic; Bacterial Proteins; Breast Neoplasms; Cell Line, Tumor; Deoxycytidine; Female; Gemcitabine; Humans; Mammary Neoplasms, Experimental; Mice; Mycoplasma hyorhinis; Mycoplasma Infections; Pyrimidine Phosphorylases; Tetrahydrouridine; Thymidine; Tumor Microenvironment

2014
Validation of a hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of gemcitabine in human plasma with tetrahydrouridine.
    Biomedical chromatography : BMC, 2015, Volume: 29, Issue:9

    Topics: Chromatography, High Pressure Liquid; Deoxycytidine; Gemcitabine; Humans; Tandem Mass Spectrometry; Tetrahydrouridine

2015