Page last updated: 2024-08-24

gemcitabine and squalene

gemcitabine has been researched along with squalene in 29 studies

Research

Studies (29)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (24.14)	29.6817
2010's	20 (68.97)	24.3611
2020's	2 (6.90)	2.80

Authors

Authors	Studies
Castelli, F; Cattel, L; Micieli, D; Rocco, F; Sarpietro, MG; Stella, B	1
Couvreur, P; Deroussent, A; Khoury, H; Paci, A; Reddy, LH; Vassal, G	1
Amenitsch, H; Bourgaux, C; Couvreur, P; Desmaële, D; Lepêtre-Mouelhi, S; Mangenot, S; Ollivon, M; Pili, B; Poupaert, JH; Reddy, LH	1
Couvreur, P; Desmaële, D; Dubernet, C; Marque, PE; Mouelhi, SL; Reddy, LH	1
Besnard, M; Chacun, H; Cintrat, JC; Couvreur, P; Declèves, X; Deroussent, A; Desmaële, D; Dubernet, C; Ferreira, H; Khoury, H; Laugier, C; Lepêtre-Mouelhi, S; Paci, A; Reddy, LH; Rousseau, B; Vassal, G	1
Arias, JL; Couvreur, P; Reddy, LH	1
Couvreur, P; Desmaele, D; Dubernet, C; Ferreira, H; Mouelhi, SL; Reddy, LH; Rousseau, B	1
Amenitsch, H; Bourgaux, C; Couvreur, P; Desmaële, D; Keller, G; Lepêtre-Mouelhi, S; Ollivon, M; Pili, B	1
Bénech, H; Bildstein, L; Chacun, H; Couvreur, P; Desmaële, D; Dubernet, C; Gueutin, C; Lepêtre-Mouelhi, S; Marsaud, V; Nicolas, V; Sarasin, A	1
Bourgaux, C; Couvreur, P; Desmaële, D; Lepêtre-Mouelhi, S; Pili, B; Reddy, LH	1
Arias, JL; Couvreur, P; Desmaële, D; Dosio, F; Gillet, B; Gref, R; Othman, M; Reddy, LH; Zouhiri, F	1
Ambike, A; Couvreur, P; Lepêtre-Mouelhi, S; Rosilio, V; Stella, B	1
Bigand, C; Couvreur, P; Hajri, A; Parmentier, C; Reddy, LH; Réjiba, S	1
Couvreur, P; Desmaële, D; Gref, R	1
Celia, C; Cosco, D; Fresta, M; Paolino, D	1
Couvreur, P; Desmaële, D; Harrisson, S; Maksimenko, A; Nicolas, J; Trung Bui, D; Vauthier, C	1
Bui, DT; Couvreur, P; Desmaële, D; Maksimenko, A; Nicolas, J	1
Alami, M; Boissenot, T; Brion, JD; Couvreur, P; Desmaële, D; Hamze, A; Maksimenko, A; Mougin, J; Provot, O; Pruvost, A; Zouhiri, F	1
Ambike, A; Bekkara-Aounallah, F; Couvreur, P; Gref, R; Rosilio, V	1
Bourgaux, C; Couvreur, P; Desmaële, D; Lepeltier, E; Maksimenko, A; Meneau, F; Rosilio, V; Sliwinski, E; Zouhiri, F	1
Cattel, L; Couvreur, P; Desmaële, D; Giraudo, E; Maione, F; Mura, S; Noiray, M; Stella, B; Valetti, S; Vauthier, C; Vergnaud, J	1
Caron, J; Couvreur, P; Desmaële, D; Maksimenko, A; Mougin, J	1
Bindra, R; Couvreur, P; Desmaële, D; Gaudin, A; King, AR; Saltzman, WM; Saucier-Sawyer, JK; Song, E	1
Andreiuk, B; Bort, G; Cayre, F; Couvreur, P; Dalbin, L; Desmaële, D; Klymchenko, AS; Lepetre-Mouelhi, S; Mougin, J; Mura, S; Paul, JL; Pieters, G; Ramseyer, C; Sobot, D; Yesylevskyy, SO	1
Buchy, E; Cayre, F; Couvreur, P; Desmaële, D; Garcia-Argote, S; Mura, S; Pieters, G; Rouquette, M; Sobot, D; Vukosavljevic, B; Windbergs, M	1
Couvreur, P; Mura, S; Ramseyer, C; Savenko, M; Yesylevskyy, SO	1
Blanco-Prieto, MJ; Couvreur, P; Desmaële, D; Irusta, S; Rodríguez-Nogales, C; Sebastián, V	1
Blanco-Prieto, MJ; Couvreur, P; Desmaële, D; Rodríguez-Nogales, C; Sebastián, V	1
Coppens, E; Couvreur, P; Lirussi, F; Lopez, T; Mura, S; Pyrshev, K; Ramseyer, C; Rivel, T; Yesylevskyy, S	1

Reviews

2 review(s) available for gemcitabine and squalene

Article	Year
Squalenoylation: a generic platform for nanoparticular drug delivery. Journal of controlled release : official journal of the Controlled Release Society, 2012, Jul-20, Volume: 161, Issue:2 Topics: Animals; Antineoplastic Agents; Antiviral Agents; Deoxycytidine; Didanosine; Drug Delivery Systems; Gemcitabine; Humans; Nanoparticles; Squalene; Zalcitabine	2012
Gemcitabine-loaded innovative nanocarriers vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity. Expert opinion on drug delivery, 2011, Volume: 8, Issue:12 Topics: Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Drug Carriers; Gemcitabine; Humans; Liposomes; Nanoparticles; Neoplasms; Polymers; Squalene; Tissue Distribution	2011

Other Studies

27 other study(ies) available for gemcitabine and squalene

Article	Year
Enhancement of gemcitabine affinity for biomembranes by conjugation with squalene: differential scanning calorimetry and Langmuir-Blodgett studies using biomembrane models. Journal of colloid and interface science, 2007, Dec-01, Volume: 316, Issue:1 Topics: Calorimetry, Differential Scanning; Deoxycytidine; Dimyristoylphosphatidylcholine; Gemcitabine; Hot Temperature; Lipid Bilayers; Models, Biological; Molecular Structure; Phase Transition; Squalene; Surface Properties	2007
Simultaneous determination of gemcitabine and gemcitabine-squalene by liquid chromatography-tandem mass spectrometry in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Oct-15, Volume: 858, Issue:1-2 Topics: Chromatography, High Pressure Liquid; Deoxycytidine; Gemcitabine; Humans; Molecular Structure; Reproducibility of Results; Squalene; Tandem Mass Spectrometry	2007
Discovery of new hexagonal supramolecular nanostructures formed by squalenoylation of an anticancer nucleoside analogue. Small (Weinheim an der Bergstrasse, Germany), 2008, Volume: 4, Issue:2 Topics: Animals; Antineoplastic Agents; Cryoelectron Microscopy; Deoxycytidine; Gemcitabine; Leukemia P388; Macromolecular Substances; Mice; Mice, Inbred DBA; Models, Molecular; Nanostructures; Nanotechnology; Scattering, Small Angle; Squalene; X-Ray Diffraction	2008
Preclinical toxicology (subacute and acute) and efficacy of a new squalenoyl gemcitabine anticancer nanomedicine. The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:2 Topics: Animals; Antineoplastic Agents; Cytarabine; Deoxycytidine; Drug Evaluation, Preclinical; Gemcitabine; Leukemia; Mice; Mice, Inbred DBA; Nanomedicine; Nanostructures; Squalene; Treatment Outcome	2008
Squalenoylation favorably modifies the in vivo pharmacokinetics and biodistribution of gemcitabine in mice. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:8 Topics: Animals; Antineoplastic Agents; Chromatography, Liquid; Deoxycytidine; Female; Gemcitabine; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Squalene; Tandem Mass Spectrometry; Tissue Distribution	2008
Magnetoresponsive squalenoyl gemcitabine composite nanoparticles for cancer active targeting. Langmuir : the ACS journal of surfaces and colloids, 2008, Jul-15, Volume: 24, Issue:14 Topics: Antineoplastic Agents; Deoxycytidine; Electrons; Gemcitabine; Kinetics; Magnetics; Microscopy, Electron, Transmission; Molecular Structure; Nanoparticles; Spectrophotometry, Infrared; Squalene; Surface Properties; Thermodynamics; X-Ray Diffraction	2008
Squalenoyl nanomedicine of gemcitabine is more potent after oral administration in leukemia-bearing rats: study of mechanisms. Anti-cancer drugs, 2008, Volume: 19, Issue:10 Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Deoxycytidine; Gemcitabine; Leukemia, Experimental; Nanomedicine; Rats; Rats, Inbred F344; Squalene	2008
Interaction of a new anticancer prodrug, gemcitabine-squalene, with a model membrane: coupled DSC and XRD study. Biochimica et biophysica acta, 2010, Volume: 1798, Issue:8 Topics: 1,2-Dipalmitoylphosphatidylcholine; Antineoplastic Agents; Calorimetry, Differential Scanning; Deoxycytidine; Gemcitabine; Lipid Bilayers; Membranes, Artificial; Phase Transition; Prodrugs; Scattering, Radiation; Scattering, Small Angle; Squalene; Transition Temperature; X-Ray Diffraction	2010
Transmembrane diffusion of gemcitabine by a nanoparticulate squalenoyl prodrug: an original drug delivery pathway. Journal of controlled release : official journal of the Controlled Release Society, 2010, Oct-15, Volume: 147, Issue:2 Topics: Antimetabolites, Antineoplastic; Autoradiography; Cell Line, Tumor; Cell Membrane; Cell Survival; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Carriers; Drug Compounding; Gemcitabine; Humans; Nanoparticles; Particle Size; Prodrugs; Squalene; Subcellular Fractions; Surface-Active Agents; Tandem Mass Spectrometry; Tissue Distribution	2010
Liposomal squalenoyl-gemcitabine: formulation, characterization and anticancer activity evaluation. Nanoscale, 2010, Volume: 2, Issue:8 Topics: Animals; Antimetabolites, Antineoplastic; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Deoxycytidine; Gemcitabine; Leukemia; Liposomes; Mice; Particle Size; Polyethylene Glycols; Prodrugs; Scattering, Small Angle; Squalene; X-Ray Diffraction	2010
Squalene based nanocomposites: a new platform for the design of multifunctional pharmaceutical theragnostics. ACS nano, 2011, Feb-22, Volume: 5, Issue:2 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Delayed-Action Preparations; Deoxycytidine; Drug Delivery Systems; Gemcitabine; Hydrophobic and Hydrophilic Interactions; Magnetic Resonance Imaging; Magnetics; Magnetite Nanoparticles; Mice; Nanocomposites; Nanomedicine; Neoplasms; Prodrugs; Squalene; Xenograft Model Antitumor Assays	2011
Interaction of self-assembled squalenoyl gemcitabine nanoparticles with phospholipid-cholesterol monolayers mimicking a biomembrane. Langmuir : the ACS journal of surfaces and colloids, 2011, Apr-19, Volume: 27, Issue:8 Topics: Cell Membrane; Cholesterol; Deoxycytidine; Gemcitabine; Membranes, Artificial; Models, Biological; Nanoparticles; Phosphatidylcholines; Phospholipids; Squalene	2011
Squalenoyl gemcitabine nanomedicine overcomes the low efficacy of gemcitabine therapy in pancreatic cancer. Nanomedicine : nanotechnology, biology, and medicine, 2011, Volume: 7, Issue:6 Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line; Cell Line, Tumor; Deoxycytidine; Female; Gemcitabine; Humans; Mice; Mice, Nude; Nanomedicine; Nanoparticles; Pancreas; Pancreatic Neoplasms; Squalene	2011
Polymer prodrug nanoparticles based on naturally occurring isoprenoid for anticancer therapy. Biomacromolecules, 2013, Aug-12, Volume: 14, Issue:8 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colloids; Deoxycytidine; Gemcitabine; Humans; Mice; Nanocapsules; Nanoparticles; Neoplasms; Polyethylene Glycols; Polymerization; Polymethacrylic Acids; Prodrugs; Squalene; Terpenes	2013
Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy. Chemical communications (Cambridge, England), 2014, May-25, Volume: 50, Issue:40 Topics: Antimetabolites, Antineoplastic; Deoxycytidine; Drug Delivery Systems; Gemcitabine; Humans; Nanomedicine; Nanoparticles; Neoplasms; Prodrugs; Squalene; Tumor Cells, Cultured	2014
Therapeutic modalities of squalenoyl nanocomposites in colon cancer: an ongoing search for improved efficacy. ACS nano, 2014, Mar-25, Volume: 8, Issue:3 Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Deoxycytidine; Drug Carriers; Drug Design; Gemcitabine; Humans; Intracellular Space; Mice; Nanocomposites; Squalene; Stilbenes; Xenograft Model Antitumor Assays	2014
Interfacial behavior of PEGylated lipids and their effect on the stability of squalenoyl-drug nanoassemblies. International journal of pharmaceutics, 2014, Aug-25, Volume: 471, Issue:1-2 Topics: Adsorption; Cholesterol; Deoxycytidine; Drug Carriers; Drug Compounding; Drug Stability; Gemcitabine; Hydrophobic and Hydrophilic Interactions; Microscopy, Electron, Transmission; Nanoparticles; Particle Size; Polyethylene Glycols; Prodrugs; Squalene; Surface Tension; Zalcitabine	2014
Self-assembly of polyisoprenoyl gemcitabine conjugates: influence of supramolecular organization on their biological activity. Langmuir : the ACS journal of surfaces and colloids, 2014, Jun-10, Volume: 30, Issue:22 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Gemcitabine; Humans; Mice; Microscopy, Confocal; Nanoparticles; Squalene	2014
Peptide-functionalized nanoparticles for selective targeting of pancreatic tumor. Journal of controlled release : official journal of the Controlled Release Society, 2014, Oct-28, Volume: 192 Topics: Amino Acid Sequence; Animals; Antimetabolites, Antineoplastic; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Gemcitabine; Humans; Male; Mice, Inbred C57BL; Nanoparticles; Pancreatic Neoplasms; Peptides; Prodrugs; Squalene	2014
Gemcitabine-based therapy for pancreatic cancer using the squalenoyl nucleoside monophosphate nanoassemblies. International journal of pharmaceutics, 2015, Mar-30, Volume: 482, Issue:1-2 Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Cell Survival; Deoxycytidine; Female; Gemcitabine; Humans; Ki-67 Antigen; Mice; Nanomedicine; Nanoparticles; Neoplasm Invasiveness; Pancreatic Neoplasms; Prodrugs; Squalene; Xenograft Model Antitumor Assays	2015
PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma. Biomaterials, 2016, Volume: 105 Topics: Absorption, Physicochemical; Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Deoxycytidine; Diffusion; Dose-Response Relationship, Drug; Gemcitabine; Glioblastoma; Humans; Molecular Imaging; Nanocapsules; Polyethylene Glycols; Rats; Squalene; Treatment Outcome	2016
Conjugation of squalene to gemcitabine as unique approach exploiting endogenous lipoproteins for drug delivery. Nature communications, 2017, 05-30, Volume: 8 Topics: A549 Cells; Animals; Calorimetry; Cell Line; Cell Line, Tumor; Cholesterol; Deoxycytidine; Drug Delivery Systems; Fluorescence Resonance Energy Transfer; Gemcitabine; Humans; Ligands; Lipoproteins; Liposomes; MCF-7 Cells; Nanoparticles; Neoplasms; Rats; Receptors, LDL; Squalene	2017
Circulating Lipoproteins: A Trojan Horse Guiding Squalenoylated Drugs to LDL-Accumulating Cancer Cells. Molecular therapy : the journal of the American Society of Gene Therapy, 2017, 07-05, Volume: 25, Issue:7 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Deoxycytidine; Drug Carriers; Female; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Lipoproteins, LDL; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Mice, SCID; Nanoparticles; Receptors, LDL; Squalene; Tumor Burden; Xenograft Model Antitumor Assays	2017
Low-Density Lipoproteins and Human Serum Albumin as Carriers of Squalenoylated Drugs: Insights from Molecular Simulations. Molecular pharmaceutics, 2018, 02-05, Volume: 15, Issue:2 Topics: Adenine; Binding Sites; Deoxycytidine; Doxorubicin; Drug Carriers; Drug Compounding; Gemcitabine; Humans; Hydrophobic and Hydrophilic Interactions; Lipoproteins, LDL; Molecular Docking Simulation; Molecular Dynamics Simulation; Nanoparticles; Protein Binding; Serum Albumin, Human; Squalene	2018
A unique multidrug nanomedicine made of squalenoyl-gemcitabine and alkyl-lysophospholipid edelfosine. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2019, Volume: 144 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Deoxycytidine; Gemcitabine; Humans; Lysophospholipids; Microscopy, Electron, Transmission; Nanomedicine; Particle Size; Phospholipid Ethers; Prodrugs; Squalene	2019
Decoration of Squalenoyl-Gemcitabine Nanoparticles with Squalenyl-Hydroxybisphosphonate for the Treatment of Bone Tumors. ChemMedChem, 2021, 12-14, Volume: 16, Issue:24 Topics: Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Gemcitabine; Humans; Molecular Structure; Nanoparticles; Organophosphonates; Osteosarcoma; Squalene; Structure-Activity Relationship	2021
Plasma membrane lipid bilayer is druggable: Selective delivery of gemcitabine-squalene nano-medicine to cancer cells. Biochimica et biophysica acta. Molecular basis of disease, 2023, Volume: 1869, Issue:2 Topics: Cell Membrane; Gemcitabine; Lipid Bilayers; Neoplasms; Prodrugs; Squalene	2023