Page last updated: 2024-08-24

gemcitabine and folic acid

gemcitabine has been researched along with folic acid in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (25.00)29.6817
2010's18 (56.25)24.3611
2020's6 (18.75)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Bunn, PA1
Höffken, K; Kliche, KO; Kubsch, K; Masri-Zada, R; Raida, M1
Kindler, HL1
Büchler, MW; Dunn, JA; Friess, H; Ghaneh, P; Hickey, H; Neoptolemos, JP; Raraty, MG; Stocken, DD1
Caliceti, P; Cavallaro, G; Gaetano, G; Licciardi, M; Mariano, L; Salmaso, S1
Atienza, D; Awasthi, S; Berry, W; Delaune, R; Deutsch, M; Dien, PY; Gregory, TF; Hood, K; Hutson, TE; Ilegbodu, D; Kolodziej, MJ; Mull, S; Muscato, JJ; Nicol, S; Raju, RN; Ruxer, RL; Vukelja, S1
Arpicco, S; Canal, F; Dalla Via, L; Pasut, G; Schiavon, O; Veronese, FM1
Aghajanian, CA; Fury, M; Gerst, S; Goss, TL; Hensley, ML; Konner, J; Larkin, J; Orlando, M; Sabbatini, P; Tai, DF1
Cavallaro, G; Celia, C; Fresta, M; Giammona, G; Licciardi, M; Paolino, D2
Jain, NK; Jain, V; Mehra, NK; Singh, R1
Wang, J; Xu, Q; Xu, S; Zhang, L; Zhang, N; Zhou, J1
Carazo, A; Delgado, AV; Gómez-Sotomayor, R; Munoz-Gamez, JA; Rudzka, K; Ruiz-Extremera, A; Salmerón, J; Viota, JL1
Han, JH; He, Y; Hong, KS; Jeon, HM; Kang, C; Kim, JS; Lee, H; Lee, JH; Park, N; Yang, Z1
Matsumoto, K; Onda, T; Yaegashi, N1
Alam, N; Dubey, RD; Gupta, PN; Khare, V; Kumar, A; Mahajan, G; Mondhe, DM; Saneja, A; Sharma, PR; Singh, SK; Vaidh, S1
Moghanaki, AA; Pourjavadi, A; Tehrani, ZM1
Cao, Y; Ma, Q; Wang, F; Wang, Y; Yu, B1
Hepel, M; Kurzątkowska, K; Santiago, T1
Amini, M; Atyabi, F; Dinarvand, R; Mirzaie, ZH; Mirzazadeh Tekie, FS; Mottaghitalab, F; Norouzi, P1
DeVaux, RS; Espinal, R; Hepel, M; Herschkowitz, JI; Kurzatkowska, K; Santiago, T1
Leblanc, RM; Pardo, J; Peng, Z1
Muddana Eswara, BR; Panduragaiah, VM; Sidramappa, MA; Unnam, S1
Jain, A; Jain, AK; Prajapati, SK; Shrivastava, C1
Arteta, B; Benedicto, A; Hernandez-Unzueta, I; Herrero, A; Márquez, J; Olaso, E; Romayor, I; Sanz, E1
Cianflone, E; Cilurzo, F; Cristiano, MC; Da Pian, M; Paolino, D; Pasut, G; Quintieri, L1
Debnath, MC; Ganguly, S; Kazi, J; Mukhopadhyay, R; Paul, B; Sen, R1
Balasubramaniam, DK; Gregory, M; Hariharan, S; Karuppaiah, A; Rajan, R; Sankar, V1
Eleraky, NE; Hasan, OA; Omar, MM; Zaki, RM1
Honeywell, RJ; Opperman, RCM; Peters, GJ; Poel, D; van der Vliet, HJ; van Zweeden, AA; Verheul, HMW1
Babu, D; Gautam, M; Karuppaiah, A; Natrajan, T; Nesamony, J; Rajan, R; Ranganathan, H; Sankar, V; Selvaraj, D; Siram, K1

Reviews

6 review(s) available for gemcitabine and folic acid

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Incorporation of pemetrexed (Alimta) into the treatment of non-small cell lung cancer (thoracic tumors).
    Seminars in oncology, 2002, Volume: 29, Issue:3 Suppl 9

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Gemcitabine; Glutamates; Guanine; Humans; Lung Neoplasms; Mesothelioma; Pemetrexed; Pleural Neoplasms; Thymidylate Synthase; Vitamin B 12

2002
Pemetrexed in pancreatic cancer.
    Seminars in oncology, 2002, Volume: 29, Issue:6 Suppl 18

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Deoxycytidine; Folic Acid; Folic Acid Antagonists; Gemcitabine; Glutamates; Guanine; Humans; Pancreatic Neoplasms; Pemetrexed; Thymidylate Synthase; Vitamin B 12

2002
[Adjuvant and additive therapy for cancer of the pancreas].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 2003, Volume: 74, Issue:3

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuvant; Clinical Trials as Topic; Clinical Trials, Phase III as Topic; Combined Modality Therapy; Controlled Clinical Trials as Topic; Deoxycytidine; Doxorubicin; Female; Fluorouracil; Folic Acid; Gemcitabine; Hematinics; Humans; Leucovorin; Male; Mitoxantrone; Multicenter Studies as Topic; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Pancreatic Neoplasms; Quality of Life; Radiotherapy Dosage; Randomized Controlled Trials as Topic; Retrospective Studies; Surveys and Questionnaires; Time Factors

2003
Pharmacotherapy for recurrent ovarian cancer: current status and future perspectives.
    Japanese journal of clinical oncology, 2015, Volume: 45, Issue:5

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carboplatin; Carcinoma, Ovarian Epithelial; Deoxycytidine; Doxorubicin; Everolimus; Female; Folic Acid; Gemcitabine; Humans; Indazoles; Neoplasm Recurrence, Local; Neoplasms, Glandular and Epithelial; Nivolumab; Ovarian Neoplasms; Paclitaxel; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Polyethylene Glycols; Pyrimidines; Quinazolines; Recombinant Fusion Proteins; Sirolimus; Sulfonamides; Topotecan; TOR Serine-Threonine Kinases; Vinca Alkaloids

2015
Cancer Targeting and Drug Delivery Using Carbon-Based Quantum Dots and Nanotubes.
    Molecules (Basel, Switzerland), 2018, Feb-10, Volume: 23, Issue:2

    Topics: Antineoplastic Agents; Deoxycytidine; Doxorubicin; Drug Carriers; Drug Liberation; Fluorescent Dyes; Folic Acid; Gemcitabine; Humans; Hyaluronic Acid; Molecular Targeted Therapy; Nanotubes, Carbon; Neoplasms; Quantum Dots; Surface Properties; Transferrin

2018

Trials

3 trial(s) available for gemcitabine and folic acid

ArticleYear
Chronomodulated chemotherapy in metastatic gastrointestinal cancer combining 5-FU and sodium folinate with oxaliplatin, irinotecan or gemcitabine: the Jena experience in 79 patients.
    Journal of cancer research and clinical oncology, 2002, Volume: 128, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Biliary Tract Neoplasms; Camptothecin; Colorectal Neoplasms; Deoxycytidine; Female; Fluorouracil; Folic Acid; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Organoplatinum Compounds; Oxaliplatin; Pancreatic Neoplasms; Stomach Neoplasms

2002
Phase I study of a 3-drug regimen of gemcitabine/cisplatin/pemetrexed in patients with metastatic transitional cell carcinoma of the urothelium.
    Investigational new drugs, 2008, Volume: 26, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Cisplatin; Deoxycytidine; Dose-Response Relationship, Drug; Female; Folic Acid; Gemcitabine; Glutamates; Guanine; Hematologic Diseases; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Metastasis; Pemetrexed; Treatment Outcome; Urinary Bladder Neoplasms; Urothelium; Vitamin B 12; Vitamin B Complex

2008
A phase I trial of pemetrexed plus gemcitabine given biweekly with B-vitamin support in solid tumor malignancies or advanced epithelial ovarian cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Oct-01, Volume: 14, Issue:19

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Deoxycytidine; Dietary Supplements; Drug Administration Schedule; Female; Folic Acid; Gemcitabine; Glutamates; Guanine; Humans; Maximum Tolerated Dose; Neoplasms; Neutropenia; Ovarian Neoplasms; Pemetrexed; Treatment Outcome; Vitamin B Complex

2008

Other Studies

23 other study(ies) available for gemcitabine and folic acid

ArticleYear
Folate-mediated targeting of polymeric conjugates of gemcitabine.
    International journal of pharmaceutics, 2006, Jan-13, Volume: 307, Issue:2

    Topics: Antimetabolites, Antineoplastic; Carrier Proteins; Cell Line, Tumor; Cell Survival; Deoxycytidine; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Gemcitabine; Humans; Hydrogen-Ion Concentration; Polyhydroxyethyl Methacrylate; Prodrugs; Receptors, Cell Surface; Succinates; Time Factors

2006
Antitumoral activity of PEG-gemcitabine prodrugs targeted by folic acid.
    Journal of controlled release : official journal of the Controlled Release Society, 2008, May-08, Volume: 127, Issue:3

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Cytidine Deaminase; Deoxycytidine; Drug Carriers; Drug Stability; Female; Folic Acid; Gemcitabine; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Neoplasms; Polyethylene Glycols; Prodrugs

2008
Folate-targeted supramolecular vesicular aggregates based on polyaspartyl-hydrazide copolymers for the selective delivery of antitumoral drugs.
    Biomaterials, 2010, Volume: 31, Issue:28

    Topics: Antineoplastic Agents; Azides; Biocompatible Materials; Cell Line, Tumor; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Folic Acid; Gemcitabine; Humans; Materials Testing; Microscopy, Confocal; Molecular Structure; Peptides; Polymers; Tissue Distribution

2010
Folate-targeted supramolecular vesicular aggregates as a new frontier for effective anticancer treatment in in vivo model.
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2012, Volume: 82, Issue:1

    Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Female; Folic Acid; Gemcitabine; Humans; Hydrazines; Liposomes; MCF-7 Cells; Mice; Mice, Inbred NOD; Mice, SCID; Nylons; Xenograft Model Antitumor Assays

2012
Gemcitabine-loaded smart carbon nanotubes for effective targeting to cancer cells.
    Journal of drug targeting, 2013, Volume: 21, Issue:6

    Topics: Cell Line, Tumor; Chemistry, Pharmaceutical; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Folic Acid; Gemcitabine; Humans; MCF-7 Cells; Nanotubes, Carbon; Neoplasms; Spectroscopy, Fourier Transform Infrared; X-Ray Diffraction

2013
Preparation and characterization of folate-chitosan-gemcitabine core-shell nanoparticles for potential tumor-targeted drug delivery.
    Journal of nanoscience and nanotechnology, 2013, Volume: 13, Issue:1

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Chitosan; Delayed-Action Preparations; Deoxycytidine; Diffusion; Folic Acid; Gemcitabine; Humans; Materials Testing; Nanocapsules; Pancreatic Neoplasms; Porosity; Treatment Outcome

2013
Functionalized magnetic nanoparticles as vehicles for the delivery of the antitumor drug gemcitabine to tumor cells. Physicochemical in vitro evaluation.
    Materials science & engineering. C, Materials for biological applications, 2013, Apr-01, Volume: 33, Issue:3

    Topics: Acrylic Resins; Adsorption; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Chemical Phenomena; Deoxycytidine; Drug Delivery Systems; Electrophoresis; Folic Acid; Gemcitabine; Humans; Hydrogen-Ion Concentration; Magnetite Nanoparticles; Microscopy, Confocal; Neoplasms; Optical Imaging; Particle Size

2013
Folate-based near-infrared fluorescent theranostic gemcitabine delivery.
    Journal of the American Chemical Society, 2013, Aug-07, Volume: 135, Issue:31

    Topics: Animals; Antimetabolites, Antineoplastic; Carbocyanines; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Fluorescent Dyes; Folic Acid; Gemcitabine; Humans; KB Cells; Mice; Neoplasms; Optical Imaging; Sulfhydryl Compounds

2013
Development and evaluation of folate functionalized albumin nanoparticles for targeted delivery of gemcitabine.
    International journal of pharmaceutics, 2015, Aug-15, Volume: 492, Issue:1-2

    Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Ehrlich Tumor; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Delivery Systems; Drug Liberation; Folic Acid; Gemcitabine; Hemolysis; Humans; Male; Mice; Nanoparticles; Serum Albumin, Bovine

2015
Folate-Conjugated pH-Responsive Nanocarrier Designed for Active Tumor Targeting and Controlled Release of Gemcitabine.
    Pharmaceutical research, 2016, Volume: 33, Issue:2

    Topics: Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; Cell Line, Tumor; Delayed-Action Preparations; Deoxycytidine; Drug Delivery Systems; Folic Acid; Gemcitabine; Graphite; Humans; Hydrogen-Ion Concentration; Nanoparticles; Polyethylene Glycols; Silicon Dioxide

2016
Development and characterization of folic acid-conjugated chitosan nanoparticles for targeted and controlled delivery of gemcitabinein lung cancer therapeutics.
    Artificial cells, nanomedicine, and biotechnology, 2017, Volume: 45, Issue:8

    Topics: A549 Cells; Animals; Biological Transport; Chitosan; Delayed-Action Preparations; Deoxycytidine; Drug Carriers; Drug Liberation; Folic Acid; Gemcitabine; Humans; Lung Neoplasms; Mice; Nanoparticles; Particle Size; Polyethylene Glycols; Tissue Distribution

2017
Plasmonic nanocarrier grid-enhanced Raman sensor for studies of anticancer drug delivery.
    Biosensors & bioelectronics, 2017, May-15, Volume: 91

    Topics: Antineoplastic Agents; Biosensing Techniques; Delayed-Action Preparations; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Equipment Design; Folic Acid; Gemcitabine; Glutathione; Gold; Humans; Hydrogen-Ion Concentration; Metal Nanoparticles; Spectrum Analysis, Raman

2017
Design and fabrication of dual-targeted delivery system based on gemcitabine-conjugated human serum albumin nanoparticles.
    Chemical biology & drug design, 2020, Volume: 96, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Cell Membrane Permeability; Cell Proliferation; Deoxycytidine; Drug Compounding; Drug Liberation; Folic Acid; Folic Acid Transporters; Gemcitabine; Glutathione; Humans; Hydrogen-Ion Concentration; Molecular Targeted Therapy; Nanocapsules; Serum Albumin, Human

2020
Surface-enhanced Raman scattering investigation of targeted delivery and controlled release of gemcitabine.
    International journal of nanomedicine, 2017, Volume: 12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Delayed-Action Preparations; Deoxycytidine; Doxorubicin; Drug Delivery Systems; Female; Folic Acid; Gemcitabine; Gold; Humans; Hydrogen-Ion Concentration; Metal Nanoparticles; Molecular Targeted Therapy; Spectrum Analysis, Raman; Transferrin; Triple Negative Breast Neoplasms

2017
Gemcitabine-loaded Folic Acid Tagged Liposomes: Improved Pharmacokinetic and Biodistribution Profile.
    Current drug delivery, 2019, Volume: 16, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Survival; Deoxycytidine; Drug Liberation; Female; Folic Acid; Gemcitabine; HeLa Cells; Humans; Liposomes; Mice; Phosphatidylethanolamines; Polyethylene Glycols; Tissue Distribution

2019
Hyaluronic acid conjugated multi-walled carbon nanotubes for colon cancer targeting.
    International journal of biological macromolecules, 2019, Feb-15, Volume: 123

    Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Folic Acid; Gemcitabine; Humans; Hyaluronic Acid; Nanotubes, Carbon; Rats

2019
Ocoxin Oral Solution Exerts an Antitumoral Effect in Pancreatic Cancer and Reduces the Stromal-Mediated Chemoresistance.
    Pancreas, 2019, Volume: 48, Issue:4

    Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Ascorbic Acid; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Resistance, Neoplasm; Folic Acid; Gemcitabine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Mice, Inbred C57BL; Neoplasms, Experimental; Paclitaxel; Pancreatic Neoplasms; Pantothenic Acid; Plant Extracts; Solutions; Vitamin B 12; Vitamin B 6; Zinc Sulfate

2019
Overcoming Cancer Cell Drug Resistance by a Folic Acid Targeted Polymeric Conjugate of Buthionine Sulfoximine.
    Anti-cancer agents in medicinal chemistry, 2019, Volume: 19, Issue:12

    Topics: A549 Cells; Antimetabolites, Antineoplastic; Buthionine Sulfoximine; Cell Proliferation; Cell Survival; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Folate Receptors, GPI-Anchored; Folic Acid; Gemcitabine; HeLa Cells; Humans; Molecular Structure; Polyethylene Glycols; Structure-Activity Relationship; Tumor Cells, Cultured

2019
Gemcitabine Co-Encapsulated with Curcumin in Folate Decorated PLGA Nanoparticles; a Novel Approach to Treat Breast Adenocarcinoma.
    Pharmaceutical research, 2020, Feb-18, Volume: 37, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Curcumin; Deoxycytidine; Drug Carriers; Drug Delivery Systems; Female; Folic Acid; Gemcitabine; Humans; Mice, Nude; Nanoparticles; Polylactic Acid-Polyglycolic Acid Copolymer

2020
Synthesis and Characterization of Folic Acid Conjugated Gemcitabine Tethered Silver Nanoparticles (FA-GEM-AgNPs) for Targeted Delivery.
    Current pharmaceutical design, 2020, Volume: 26, Issue:26

    Topics: Deoxycytidine; Folic Acid; Gemcitabine; Humans; Metal Nanoparticles; Plant Extracts; Silver

2020
Externally Triggered Novel Rapid-Release Sonosensitive Folate-Modified Liposomes for Gemcitabine: Development and Characteristics.
    International journal of nanomedicine, 2021, Volume: 16

    Topics: Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Deoxycytidine; Drug Delivery Systems; Drug Liberation; Endocytosis; Female; Folic Acid; Gemcitabine; Humans; Liposomes; Ovarian Neoplasms; Particle Size; Rats, Sprague-Dawley; Tissue Distribution; Ultrasonics

2021
The prognostic impact of circulating miRNAs in patients with advanced esophagogastric cancer during palliative chemotherapy.
    Cancer treatment and research communications, 2021, Volume: 27

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials, Phase II as Topic; Deoxycytidine; Esophageal Neoplasms; Esophagogastric Junction; Female; Folic Acid; Gemcitabine; Humans; Male; MicroRNAs; Middle Aged; Palliative Care; Prognosis; Progression-Free Survival; Randomized Controlled Trials as Topic; Stomach Neoplasms; Survival Rate

2021
Building and behavior of a pH-stimuli responsive chitosan nanoparticles loaded with folic acid conjugated gemcitabine silver colloids in MDA-MB-453 metastatic breast cancer cell line and pharmacokinetics in rats.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2021, Oct-01, Volume: 165

    Topics: Animals; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chitosan; Deoxycytidine; Female; Folic Acid; Gemcitabine; Humans; Hydrogen-Ion Concentration; Metal Nanoparticles; Nanoparticles; Particle Size; Rats; Silver

2021