Compounds > gemcitabine
Page last updated: 2024-08-24

gemcitabine and floxuridine

gemcitabine has been researched along with floxuridine in 80 studies

Research

Studies (80)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (6.25)18.2507
2000's38 (47.50)29.6817
2010's30 (37.50)24.3611
2020's7 (8.75)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Björck, L; Clausen, AR; Piskur, J; Sandrini, MP; Shannon, O1
Grube, M; Guitton, J; Hübner, T; Jedlitschky, G; Köck, K; Kowalczyk, DW; Kroemer, HK; Lerch, MM; Mayerle, J; Mews, S; Nambaru, PK; Payen, L; Rimmbach, C; Ritter, CA; Rosskopf, D; Sendler, M; Weiss, FU1
Daelemans, D; De Jonghe, S; Gao, LJ; Herdewijn, P1
Celewicz, L; Kleczewska, N; Liberska, J; Ruszkowski, P; Singh, A; Trznadel, R1
Edzes, HT; Noordhuis, P; Peters, GJ; Vermorken, JB1
Bamberger, U; Boven, E; Feller, N; Jansen, WJ; Pinedo, HM; van der Wilt, CL1
Lawrence, TS; Robertson, JM; Shewach, DS1
Grem, JL; Kao, V; Ren, Q1
Adenis, A; Conroy, T; Paillot, B1
Delauter, BJ; Egorin, MJ; Plunkett, W; Ramanathan, RK; Stover, LL; Zamboni, WC; Zuhowski, EG1
Bergström, M; Borbath, I; Grégoire, V; Långström, B; Laryea, D; Pauwels, S1
Barbieri, L; Busi, C; Di Stefano, G; Fiume, L; Lanza, M1
Blackstock, AW; Lawrence, TS; McGinn, C1
Bacher, N; Hohla, F; Irschick, E; Konwalinka, G; Mühlmann, O; Strasser-Wozak, E; Tiefenthaler, M; Wein, W1
Chen, A; Grem, JL; Hamilton, JM; Harold, N; Keith, B; Monahan, BP; Morrison, G; Nguyen, D; Pang, J; Quinn, MG; Rowedder, A; Takimoto, CH; Xu, Y1
Goh, BC; Lee, HS; Noordhuis, P; Peters, GJ; Wang, LZ1
Beryt, M; Konecny, GE; O'Callaghan, C; Pegram, MD; Pietras, R; Slamon, DJ1
Bettinelli, M; Minoia, C; Sottani, C; Zaffaroni, M; Zucchetti, M1
Stadler, WM1
Delaloge, S; Di Palma, M; Forgue, ST; Le Chevalier, T; Llombart, A; Ni, L; Tourani, JM; Turpin, F1
Aksoy, Y; Kadioğlu, YY; Yilmaz, B1
Buesa, JM; Díaz, A; Esteban, E; Fernández, A; Fra, J; López-Pousa, A; Losa, R; Sierra, M1
Fan, Y; Fang, L; Lin, NM; Ma, SL; Zeng, S; Zhong, HJ1
Bang, SM; Chung, HW; Chung, JB; Kang, JK; Kim, JW; Lee, WJ; Park, SW; Seong, JS; Song, SY1
Furuse, J; Hasegawa, R; Ikeda, M; Ishii, H; Kaniwa, N; Kikura-Hanajiri, R; Kim, SR; Okusaka, T; Ozawa, S; Saijo, N; Saito, Y; Sawada, J; Sugiyama, E; Ueno, H; Yamamoto, N; Yonemori, K; Yoshida, T1
Baas, P; Beijnen, JH; Crul, M; Pluim, D; Rademaker-Lakhai, JM; Schellens, JH; Sparidans, RW; van Zandwijk, N1
Amidon, GL; Landowski, CP; Lorenzi, PL; Song, X1
Freise, KJ; Martín-Jiménez, T2
Dagit, JW; Fisher, JE; Guire, DE; Hassan, I; Kirstein, MN; Remmel, RP; Weller, DR1
Lawrence, TS; Maybaum, J; Morgan, MA; Parsels, JD; Parsels, LA1
Kondo, T; Matsuo, R; Moon, Y; Ohkohchi, N; Ohshiro, Y; Takeshima, T; Todoroki, T; Yamamoto, Y1
Beijnen, JH; Rosing, H; Schellens, JH; Thijssen, B; Vainchtein, LD1
Cerny, T; Früh, M; Lanz, C; Lauterburg, BH; Thormann, W1
Chen, Q; Chen, TG; Hao, MZ; Lin, HL; Wu, H; Yu, WC1
Caffo, O; D'Incalci, M; Galligioni, E; Marangon, E; Sala, F; Zucchetti, M1
Bang, SJ; Joo, KR; Kim, H; Kim, MJ; Min, YJ; Nah, YW; Nam, CW; Park, JH; Park, NH; Shin, SJ1
Hirobe, M; Itoh, T; Kunishima, Y; Masumori, N; Takayanagi, A; Takeuchi, M; Tsukamoto, T1
Baayen, JC; Bergman, AM; de Lange, SM; Dirven, CM; Giaccone, G; Honeywell, RJ; Laan, AC; Peters, GJ; Postma, TJ; Sigmond, J; van der Born, K; Van Groeningen, CJ1
Beijnen, JH; Bolijn, MJ; Govindarajan, R; Ong, FH; Pluim, D; Schellens, JH; Unadkat, JD; van Eijndhoven, MA; Veltkamp, SA1
Hollender, J; Kovalova, L; McArdell, CS1
Beijnen, JH; Jansen, RS; Rosing, H; Schellens, JH1
Citro, G; Cognetti, F; Colantonio, S; Contestabile, M; Di Segni, S; Felici, A; Milella, M; Nuvoli, B; Sacconi, A; Sperduti, I; Zaratti, M1
Bowen, C; Licea-Perez, H; Wang, S1
Hollender, J; Kovalova, L; Mcardell, CS; Moser, R; Ort, C; Pazhepurackel, V; Siegrist, H; Weissbrodt, D1
Celia, C; Cosco, D; Costante, G; Filetti, S; Fresta, M; Iannone, M; Paolino, D; Puxeddu, E; Racanicchi, L; Russo, D; Trapasso, E1
Boezen, HM; de Vries, EG; Groen, HJ; Maring, JG; Maurer, JM; Slijfer, M; Uges, DR; Wachters, FM1
Furuse, J; Hasegawa, R; Ikeda, M; Ishii, H; Kaniwa, N; Kim, SR; Kondo, S; Morizane, C; Okusaka, T; Saijo, N; Saito, Y; Sawada, J; Sugiyama, E; Tamura, T; Ueno, H; Yamamoto, N; Yoshida, T1
Aelbrecht, K; De Boeck, G; Dyck, J; Guetens, G; Specenier, P; Van den Weyngaert, D; Vermorken, JB; Weyler, J1
Benyumov, A; Gurvich, VJ; Kirstein, MN; Lis, LG; Williams, BW1
Hodge, LS; Taub, ME; Tracy, TS2
Bapiro, TE; Cook, N; Frese, KK; Goldgraben, MA; Griffiths, JR; Jacobetz, MA; Jodrell, DI; Madhu, B; Olive, KP; Richards, FM; Smith, DM; Tuveson, DA1
Giovannetti, E; Honeywell, RJ; Peters, GJ1
Jafari, M; Kislukhin, G; Long, AD; Murphy, ML1
Egawa, S; Kawaguchi, K; Motoi, F; Ohmine, K; Ohtsuki, S; Terasaki, T; Unno, M1
Dudek, AZ; Greeno, EW; Khatri, A; Kirstein, MN; Kratzke, RA; Lamba, JK; Mitra, AK; Skubitz, KM1
Casado, FJ; Molina-Arcas, M; Pastor-Anglada, M; Pérez-Torras, S; Trigueros-Motos, L1
Chen, H; Fan, B; Fang, S; Lu, Q; Sun, Y; Tang, D; Wei, Y; Yin, J; Yin, X; Zhang, B; Zhang, F1
Lee, LB; Ruterbories, KJ; Schmalz, CA; Torchia, J; Wickremsinhe, ER1
Bae, KS; Cho, JM; Choi, HJ; Go, SI; Kang, MH; Kim, DC; Kim, HG; Kim, MJ; Lee, JH; Lee, US; Lee, WS1
Honeywell, RJ; Peters, GJ; Ruiz van Haperen, VW; Smid, K; Veerman, G1
Bjånes, T; Eide, T; Kamčeva, T; Riedel, B; Schjøtt, J; Svardal, A1
Chen, D; Di Cresce, C; Ferguson, PJ; Figueredo, R; Koropatnick, J; Maleki Vareki, S; Min, W; Pampillo, M; Rytelewski, M; Vincent, M; Zheng, X1
Allen, PJ; D'Angelica, MI; DeMatteo, RP; Do, RK; Fong, Y; Gönen, M; Groot Koerkamp, B; Jarnagin, WR; Kemeny, NE; Kingham, TP; Klimstra, DS; Konstantinidis, IT1
Honeywell, RJ; Kathmann, I; Kristensen, MH; Peters, GJ; Sarkisjan, D1
Bapiro, TE; Chen, N; Ellenrieder, V; Frese, KK; Gopinathan, A; Gress, TM; Hessmann, E; Heuchel, R; Jodrell, DI; Johnsen, SA; Kari, V; Klein, L; Li, X; Löhr, JM; Neesse, A; Patzak, MS; Ramu, I; Richards, FM; Verbeke, C1
Do, C; Han, Y; Smith, GS; Zhang, Z1
Chen, T; Han, H; Ji, J; Jin, Q; Wang, J; Yin, L1
Beijnen, JH; Burgers, JA; Hillebrand, MJX; Rosing, H; Schellens, JHM; van Nuland, M1
Beijnen, JH; Derissen, EJB; Huitema, ADR; Rosing, H; Schellens, JHM1
Aa, L; Fei, F; Hao, K; Jiang, W; Liu, J; Lu, L; Pei, X; Peng, Y; Sun, Y; Wang, G; Wang, J; Zhen, L1
Allen, PJ; Balachandran, VP; Boerner, T; Boucher, TM; Cercek, A; Chapman, WC; Chou, JF; D'Angelica, MI; DeMatteo, RP; Diaz, LA; Do, RKG; Drebin, JA; Fields, RC; Gönen, M; Harding, JJ; Hauser, HF; Hawkins, WG; Jarnagin, WR; Kemeny, NE; Kingham, TP; Lim, KH; Lowery, MA; Majella Doyle, MB; Reidy-Lagunes, D; Saltz, L; Sanchez-Vega, F; Schultz, N; Strasberg, SM; Tan, BR; Vachharajani, N; Varghese, AM1
Li, G; Li, H; Peng, C; Shi, L; Zhou, C1
Pan, J; Yang, X; Zhao, H1
Cercek, A; Jarnagin, WR1
Akhoundova, D; Bachmann, H; Breitenstein, S; Clavien, PA; Knuth, A; Nguyen-Kim, TDL; Pestalozzi, B; Petrowsky, H; Pietge, H; Samaras, P; Sánchez-Velázquez, P; Siebenhüner, A; Winder, T1
Davis, A; Gibson, EG; Roussel, MF; Stewart, CF; Zhong, B1
Chang, I; Chang, WJ; Chen, R; Circelli, J; Harpel, Z; Rivera, J; Wei, R; Wu, S1

Reviews

3 review(s) available for gemcitabine and floxuridine

ArticleYear
Preclinical studies of chemotherapy and radiation therapy for pancreatic carcinoma.
    Cancer, 1996, Aug-01, Volume: 78, Issue:3 Suppl

    Topics: Antimetabolites, Antineoplastic; Bromodeoxyuridine; Combined Modality Therapy; Deoxycytidine; Floxuridine; Fluorouracil; Gemcitabine; Idoxuridine; Pancreatic Neoplasms; Radiation-Sensitizing Agents; Tumor Cells, Cultured

1996
[New drugs in gastrointestinal oncology. Current status and future directions].
    Gastroenterologie clinique et biologique, 1999, Volume: 23, Issue:11

    Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Taxoids; Tegafur; Thiophenes; Vinblastine; Vinorelbine

1999
The mechanism of action of radiosensitization of conventional chemotherapeutic agents.
    Seminars in radiation oncology, 2003, Volume: 13, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Floxuridine; Fluorouracil; Gemcitabine; Humans; Neoplasms; Radiation-Sensitizing Agents; Randomized Controlled Trials as Topic; Risk Factors

2003

Trials

14 trial(s) available for gemcitabine and floxuridine

ArticleYear
A phase I and pharmacologic study of weekly gemcitabine in combination with infusional 5-fluorodeoxyuridine and oral calcium leucovorin.
    Cancer chemotherapy and pharmacology, 2003, Volume: 52, Issue:6

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Drug Administration Schedule; Female; Floxuridine; Gemcitabine; Humans; Infusions, Intravenous; Leucovorin; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Neutropenia; Ribonucleotide Reductases; Thrombocytopenia

2003
Gemcitabine in patients with solid tumors and renal impairment: a pharmacokinetic phase I study.
    American journal of clinical oncology, 2004, Volume: 27, Issue:3

    Topics: Antimetabolites, Antineoplastic; Deoxycytidine; Female; Floxuridine; Gemcitabine; Humans; Male; Middle Aged; Neoplasms; Renal Insufficiency

2004
Phase I clinical trial of fixed-dose rate infusional gemcitabine and dacarbazine in the treatment of advanced soft tissue sarcoma, with assessment of gemcitabine triphosphate accumulation.
    Cancer, 2004, Nov-15, Volume: 101, Issue:10

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Gemcitabine; Humans; Infusions, Intravenous; Leukocytes, Mononuclear; Male; Maximum Tolerated Dose; Middle Aged; Sarcoma; Treatment Outcome

2004
A prospective randomized study of gemcitabine with doxifluridine versus paclitaxel with doxifluridine in concurrent chemoradiotherapy for locally advanced pancreatic cancer.
    International journal of radiation oncology, biology, physics, 2004, Dec-01, Volume: 60, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Female; Floxuridine; Gemcitabine; Humans; Male; Middle Aged; Paclitaxel; Pancreatic Neoplasms; Radiotherapy Dosage

2004
Severe drug toxicity associated with a single-nucleotide polymorphism of the cytidine deaminase gene in a Japanese cancer patient treated with gemcitabine plus cisplatin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Apr-01, Volume: 11, Issue:7

    Topics: Aged; Amino Acid Substitution; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cisplatin; Cytidine Deaminase; Deoxycytidine; DNA Mutational Analysis; DNA, Neoplasm; Exanthema; Fatigue; Floxuridine; Gemcitabine; Genotype; Humans; Japan; Male; Middle Aged; Neoplasms; Neutropenia; Polymorphism, Single Nucleotide; Stomatitis; Thrombocytopenia; Treatment Outcome

2005
Phase I clinical and pharmacologic study of a 2-weekly administration of cisplatin and gemcitabine in patients with advanced non-small cell lung cancer.
    Anti-cancer drugs, 2005, Volume: 16, Issue:9

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; DNA Adducts; Dose-Response Relationship, Drug; Floxuridine; Gemcitabine; Humans; Leukocytes; Male; Middle Aged; Platinum; Treatment Outcome

2005
[Efficacy of transcatheter arterial chemoembolization combined thalidomide on hepatocellular carcinoma: a controlled randomized trial].
    Ai zheng = Aizheng = Chinese journal of cancer, 2007, Volume: 26, Issue:8

    Topics: Administration, Oral; Adult; Aged; Angiogenesis Inhibitors; Carcinoma, Hepatocellular; Chemoembolization, Therapeutic; Combined Modality Therapy; Deoxycytidine; Exanthema; Female; Floxuridine; Follow-Up Studies; Gemcitabine; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Survival Rate; Thalidomide; Young Adult

2007
Simultaneous determination of gemcitabine and its main metabolite, dFdU, in plasma of patients with advanced non-small-cell lung cancer by high-performance liquid chromatography-tandem mass spectrometry.
    Journal of mass spectrometry : JMS, 2008, Volume: 43, Issue:2

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Chromatography, High Pressure Liquid; Cisplatin; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Lung Neoplasms; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2008
Fixed dose rate infusion of gemcitabine with oral doxifluridine and leucovorin for advanced unresectable pancreatic cancer: a phase II study.
    Chemotherapy, 2008, Volume: 54, Issue:1

    Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease-Free Survival; Female; Floxuridine; Follow-Up Studies; Gemcitabine; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Pancreatic Neoplasms; Remission Induction; Survival Analysis; Treatment Outcome

2008
Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2009, Volume: 20, Issue:1

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biological Availability; Biopsy; Brain Neoplasms; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Female; Floxuridine; Gemcitabine; Glioblastoma; Humans; Male; Middle Aged; Nucleoside Deaminases; Radiation-Sensitizing Agents

2009
Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism.
    European journal of clinical pharmacology, 2010, Volume: 66, Issue:6

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cytidine Deaminase; Deoxycytidine; Female; Floxuridine; Gemcitabine; Gene Frequency; Genotype; Humans; Lung Neoplasms; Male; Metabolic Clearance Rate; Middle Aged; Polymorphism, Single Nucleotide

2010
Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:6

    Topics: Activation, Metabolic; Antimetabolites, Antineoplastic; Breast Neoplasms; Cytidine Triphosphate; Deamination; Deoxycytidine; Female; Floxuridine; Gemcitabine; Humans; Leukocytes, Mononuclear; Phosphorylation; Uridine Triphosphate

2018
Assessment of Hepatic Arterial Infusion of Floxuridine in Combination With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Clinical Trial.
    JAMA oncology, 2020, Jan-01, Volume: 6, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Gemcitabine; Humans; Liver Neoplasms; Male; Middle Aged; Oxaliplatin; Treatment Outcome

2020
Combination of HAI-FUDR and Systemic Gemcitabine and Cisplatin in Unresectable Cholangiocarcinoma: A Dose Finding Single Center Study.
    Oncology, 2021, Volume: 99, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Cholangiocarcinoma; Cisplatin; Deoxycytidine; Female; Floxuridine; Follow-Up Studies; Gemcitabine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Non-Randomized Controlled Trials as Topic; Prognosis; Prospective Studies; Survival Rate

2021

Other Studies

63 other study(ies) available for gemcitabine and floxuridine

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Deoxyribonucleoside kinases activate nucleoside antibiotics in severely pathogenic bacteria.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Animals; Anti-Bacterial Agents; Deoxycytidine; Female; Gemcitabine; Humans; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Sequence Data; Nucleosides; Phosphotransferases (Alcohol Group Acceptor); Staphylococcal Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes

2007
Drug efflux transporter multidrug resistance-associated protein 5 affects sensitivity of pancreatic cancer cell lines to the nucleoside anticancer drug 5-fluorouracil.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:1

    Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorouracil; Gene Knockdown Techniques; Humans; Multidrug Resistance-Associated Proteins; Pancreas; Pancreatic Neoplasms; RNA; RNA Interference; Tumor Cells, Cultured

2011
L-Aspartic and l-glutamic acid ester-based ProTides of anticancer nucleosides: Synthesis and antitumoral evaluation.
    Bioorganic & medicinal chemistry letters, 2016, May-01, Volume: 26, Issue:9

    Topics: Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; Drug Screening Assays, Antitumor; Glutamates; Humans; Nucleosides; Organophosphorus Compounds; Prodrugs; Structure-Activity Relationship

2016
Synthesis and in vitro anticancer activity of new gemcitabine-nucleoside analogue dimers containing methyltriazole or ester-methyltriazole linker.
    Bioorganic & medicinal chemistry letters, 2019, 09-15, Volume: 29, Issue:18

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Deoxycytidine; Dimerization; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Esters; Gemcitabine; Humans; Molecular Structure; Nucleosides; Structure-Activity Relationship; Triazoles

2019
Determination of the antimetabolite Gemcitabine (2',2'-difluoro-2'-deoxycytidine) and of 2',2'-difluoro-2'-deoxyuridine by 19F nuclear magnetic resonance spectroscopy.
    Analytical biochemistry, 1993, Volume: 214, Issue:1

    Topics: Antimetabolites, Antineoplastic; Deoxycytidine; Floxuridine; Fluorine; Gemcitabine; Humans; Magnetic Resonance Spectroscopy

1993
The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts.
    European journal of cancer (Oxford, England : 1990), 1995, Volume: 31A, Issue:13-14

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Deoxycytidine; Dipyridamole; Doxorubicin; Drug Resistance; Female; Floxuridine; Fluorouracil; Gemcitabine; Humans; Methotrexate; Mice; Mice, Nude; Morpholines; Neoplasms; Neoplasms, Experimental; Protein Binding; Transplantation, Heterologous; Triamterene; Tumor Cells, Cultured; Vincristine

1995
Cytotoxicity and DNA fragmentation associated with sequential gemcitabine and 5-fluoro-2'-deoxyuridine in HT-29 colon cancer cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1998, Volume: 4, Issue:11

    Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Colonic Neoplasms; Deoxycytidine; DNA Damage; DNA Fragmentation; DNA, Neoplasm; Floxuridine; Gemcitabine; HT29 Cells; Humans; Thymidylate Synthase

1998
Pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in a patient with ascites.
    Pharmacotherapy, 2000, Volume: 20, Issue:10

    Topics: Abdominal Pain; Adenocarcinoma; Antimetabolites, Antineoplastic; Ascites; Catheters, Indwelling; Chromatography, High Pressure Liquid; Deoxycytidine; Female; Floxuridine; Fluorouracil; Gemcitabine; Humans; Middle Aged; Pancreatic Neoplasms; Urinary Tract Infections

2000
Use of 5-[(76)Br]bromo-2'-fluoro-2'-deoxyuridine as a ligand for tumour proliferation: validation in an animal tumour model.
    European journal of nuclear medicine and molecular imaging, 2002, Volume: 29, Issue:1

    Topics: Animals; Autoradiography; Bromodeoxyuridine; Carbon Radioisotopes; Cell Division; Cimetidine; Deoxycytidine; DNA, Neoplasm; Fibrosarcoma; Flow Cytometry; Floxuridine; Gamma Cameras; Gemcitabine; Mice; Mice, Inbred C3H; Radionuclide Imaging; Radiopharmaceuticals; Scintillation Counting; Thymidine

2002
Conjugates of nucleoside analogs with lactosaminated human albumin to selectively increase the drug levels in liver blood: requirements for a regional chemotherapy.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2

    Topics: Animals; Deoxycytidine; Drug Delivery Systems; Floxuridine; Gemcitabine; Liver; Male; Models, Animal; Nucleosides; Rats; Rats, Wistar; Serum Albumin; Vidarabine

2002
In vitro studies on the immunosuppressive effect of 2',2'-difluorodeoxycytidine (dFdC) and its metabolite 2',2'-difluorodeoxyuridine (dFdU).
    Immunobiology, 2003, Volume: 207, Issue:2

    Topics: Adrenal Cortex Hormones; Antigens, CD34; Deoxycytidine; Deoxycytidine Kinase; Dose-Response Relationship, Drug; Drug Therapy, Combination; Floxuridine; Gemcitabine; HL-60 Cells; Humans; Immunosuppressive Agents; Leukocytes, Mononuclear; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Phytohemagglutinins; Stem Cells

2003
An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography.
    Therapeutic drug monitoring, 2003, Volume: 25, Issue:5

    Topics: Calibration; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Sensitivity and Specificity

2003
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer.
    Journal of the National Cancer Institute, 2004, May-19, Volume: 96, Issue:10

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Deoxycytidine; Disease Models, Animal; DNA, Neoplasm; Docetaxel; Doxorubicin; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Epirubicin; Female; Floxuridine; Gemcitabine; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; Paclitaxel; Proto-Oncogene Proteins; Receptor, ErbB-2; Taxoids; Transplantation, Heterologous; Trastuzumab; Tumor Stem Cell Assay; Up-Regulation; Vinblastine; Vinorelbine

2004
Validated procedure for simultaneous trace level determination of the anti-cancer agent gemcitabine and its metabolite in human urine by high-performance liquid chromatography with tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2004, Volume: 18, Issue:10

    Topics: Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Mass Spectrometry

2004
Cytotoxic chemotherapy for metastatic renal cell carcinoma.
    Der Urologe. Ausg. A, 2004, Volume: 43 Suppl 3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Carcinoma, Renal Cell; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Deoxycytidine; Floxuridine; Fluorouracil; Gemcitabine; Humans; Kidney Neoplasms; Neoplasm Metastasis; Survival Rate

2004
Investigation of the pharmacokinetics of gemcitabine and 2',2'-difluorodeoxyuridine in human plasma by liquid chromatography.
    Analytical biochemistry, 2004, Sep-15, Volume: 332, Issue:2

    Topics: Aged; Chromatography, High Pressure Liquid; Deoxycytidine; Female; Floxuridine; Gemcitabine; Humans; Molecular Structure

2004
Determination of gemcitabine and its metabolite in human plasma using high-pressure liquid chromatography coupled with a diode array detector.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:12

    Topics: Antimetabolites, Antineoplastic; Area Under Curve; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Middle Aged; Neoplasms

2004
Nucleoside ester prodrug substrate specificity of liver carboxylesterase.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:2

    Topics: Animals; Benzimidazoles; Caco-2 Cells; Carboxylesterase; Cytosol; Deoxycytidine; Esters; Floxuridine; Gemcitabine; Humans; Hydrolysis; Liver; Models, Molecular; Molecular Structure; Nucleosides; Prodrugs; Ribonucleosides; Substrate Specificity; Swine

2006
Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous bolus dosing and its in vitro pharmacodynamics.
    Journal of veterinary pharmacology and therapeutics, 2006, Volume: 29, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Deoxycytidine; Dogs; Female; Floxuridine; Gemcitabine; Half-Life; Metabolic Clearance Rate; Tumor Cells, Cultured

2006
Pharmacokinetics of gemcitabine and its primary metabolite in dogs after intravenous infusion.
    Journal of veterinary pharmacology and therapeutics, 2006, Volume: 29, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Deoxycytidine; Dogs; Female; Floxuridine; Gemcitabine; Half-Life; Infusions, Intravenous; Tissue Distribution

2006
High-performance liquid chromatographic method for the determination of gemcitabine and 2',2'-difluorodeoxyuridine in plasma and tissue culture media.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2006, May-01, Volume: 835, Issue:1-2

    Topics: Bioreactors; Chromatography, High Pressure Liquid; Culture Media; Deoxycytidine; Drug Stability; Floxuridine; Gemcitabine; Humans; Reproducibility of Results; Spectrophotometry, Ultraviolet

2006
The relationship of premature mitosis to cytotoxicity in response to checkpoint abrogation and antimetabolite treatment.
    Cell cycle (Georgetown, Tex.), 2006, Volume: 5, Issue:17

    Topics: Antimetabolites, Antineoplastic; Cell Cycle; Cell Line; Checkpoint Kinase 1; Checkpoint Kinase 2; Deoxycytidine; Floxuridine; Gemcitabine; Histones; Humans; Mitosis; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA Interference

2006
[A case of stage IVA intrahepatic biliary tract cancer successfully treated with gemcitabine].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:10

    Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; CA-19-9 Antigen; Carcinoembryonic Antigen; Deoxycytidine; Drug Administration Routes; Floxuridine; Gemcitabine; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Tomography, X-Ray Computed

2006
Validated assay for the simultaneous determination of the anti-cancer agent gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma by high-performance liquid chromatography with tandem mass spectrometry.
    Rapid communications in mass spectrometry : RCM, 2007, Volume: 21, Issue:14

    Topics: Antineoplastic Agents; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Complex Mixtures; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization

2007
Rapid determination of gemcitabine in plasma and serum using reversed-phase HPLC.
    Journal of separation science, 2007, Volume: 30, Issue:12

    Topics: Animals; Antimetabolites, Antineoplastic; Blood Chemical Analysis; Calibration; Chemistry, Clinical; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Male; Rats; Rats, Wistar; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Serum

2007
Measurement of plasma concentration of gemcitabine and its metabolite dFdU in hemodialysis patients with advanced urothelial cancer.
    Japanese journal of clinical oncology, 2008, Volume: 38, Issue:3

    Topics: Antimetabolites, Antineoplastic; Area Under Curve; Bone Neoplasms; Cystectomy; Deoxycytidine; Fatal Outcome; Floxuridine; Gemcitabine; Humans; Kidney Neoplasms; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Renal Dialysis; Renal Insufficiency; Ureteral Neoplasms; Urinary Bladder Neoplasms

2008
New insights into the pharmacology and cytotoxicity of gemcitabine and 2',2'-difluorodeoxyuridine.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:8

    Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Line; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Phosphorylation

2008
Challenge of high polarity and low concentrations in analysis of cytostatics and metabolites in wastewater by hydrophilic interaction chromatography/tandem mass spectrometry.
    Journal of chromatography. A, 2009, Feb-13, Volume: 1216, Issue:7

    Topics: Adsorption; Chromatography, Liquid; Cytostatic Agents; Deoxycytidine; Drug Residues; Floxuridine; Fluorouracil; Gemcitabine; Hydrophobic and Hydrophilic Interactions; Linear Models; Models, Molecular; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Water; Water Pollutants, Chemical

2009
Retention studies of 2'-2'-difluorodeoxycytidine and 2'-2'-difluorodeoxyuridine nucleosides and nucleotides on porous graphitic carbon: development of a liquid chromatography-tandem mass spectrometry method.
    Journal of chromatography. A, 2009, Apr-10, Volume: 1216, Issue:15

    Topics: Acetonitriles; Bicarbonates; Chromatography, Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Graphite; Hydrogen Peroxide; Hydrogen-Ion Concentration; Oxidation-Reduction; Porosity; Pyrimidines; Tandem Mass Spectrometry

2009
Pharmacokinetics of gemcitabine at fixed-dose rate infusion in patients with normal and impaired hepatic function.
    Clinical pharmacokinetics, 2009, Volume: 48, Issue:2

    Topics: Adenocarcinoma; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Biliary Tract Neoplasms; Chromatography, High Pressure Liquid; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Gemcitabine; Humans; Infusions, Intravenous; Liver Diseases; Liver Function Tests; Male; Middle Aged; Pancreatic Neoplasms; Prospective Studies; Tandem Mass Spectrometry

2009
Development of a sensitive and selective LC-MS/MS method for simultaneous determination of gemcitabine and 2,2-difluoro-2-deoxyuridine in human plasma.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Jul-15, Volume: 877, Issue:22

    Topics: Antineoplastic Agents; Chromatography, Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Neoplasms; Sensitivity and Specificity; Tandem Mass Spectrometry

2009
Mass flows of X-ray contrast media and cytostatics in hospital wastewater.
    Environmental science & technology, 2009, Jul-01, Volume: 43, Issue:13

    Topics: Contrast Media; Cytostatic Agents; Deoxycytidine; Environmental Monitoring; Floxuridine; Fluorouracil; Gemcitabine; Hospitals; Medical Waste Disposal; Waste Disposal, Fluid; Water Pollutants; Water Pollution, Chemical; Water Purification; X-Rays

2009
Gemcitabine-loaded PEGylated unilamellar liposomes vs GEMZAR: biodistribution, pharmacokinetic features and in vivo antitumor activity.
    Journal of controlled release : official journal of the Controlled Release Society, 2010, Jun-01, Volume: 144, Issue:2

    Topics: Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Deoxycytidine; Floxuridine; Gemcitabine; Half-Life; Liposomes; Mice; Mice, Inbred NOD; Mice, SCID; Polyethylene Glycols; Raloxifene Hydrochloride; Tissue Distribution; Unilamellar Liposomes

2010
Population pharmacokinetics of gemcitabine and its metabolite in Japanese cancer patients: impact of genetic polymorphisms.
    Clinical pharmacokinetics, 2010, Volume: 49, Issue:8

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Asian People; Computer Simulation; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Equilibrative Nucleoside Transporter 1; Female; Floxuridine; Gemcitabine; Humans; Male; Middle Aged; Neoplasms; Polymorphism, Genetic; Polymorphism, Single Nucleotide

2010
Difluorodeoxyuridine plasma concentrations after low-dose gemcitabine during chemoradiation in head and neck cancer patients.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:1

    Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Combined Modality Therapy; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Gemcitabine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Radiation-Sensitizing Agents

2011
Combinatorial pharmacologic effects of gemcitabine and its metabolite dFdU.
    ChemMedChem, 2011, Mar-07, Volume: 6, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Combinatorial Chemistry Techniques; Deoxycytidine; Deoxyuridine; Embryo, Nonmammalian; Embryonic Development; Floxuridine; Gemcitabine; Humans; Tumor Stem Cell Assay; Zebrafish

2011
Effect of its deaminated metabolite, 2',2'-difluorodeoxyuridine, on the transport and toxicity of gemcitabine in HeLa cells.
    Biochemical pharmacology, 2011, Apr-01, Volume: 81, Issue:7

    Topics: Deamination; Deoxycytidine; Floxuridine; Gemcitabine; HeLa Cells; Humans

2011
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:5

    Topics: Animals; Antineoplastic Agents; Calibration; Cytidine Triphosphate; Deoxycytidine; Disease Models, Animal; Floxuridine; Fluorine; Gemcitabine; Humans; Magnetic Resonance Spectroscopy; Mice; Reference Standards; Tandem Mass Spectrometry

2011
The deaminated metabolite of gemcitabine, 2',2'-difluorodeoxyuridine, modulates the rate of gemcitabine transport and intracellular phosphorylation via deoxycytidine kinase.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:11

    Topics: Antineoplastic Agents; Biological Transport; Deamination; Deoxycytidine; Deoxycytidine Kinase; Floxuridine; Gemcitabine; HeLa Cells; Humans; Inactivation, Metabolic; Phosphorylation; Polyphosphates; RNA, Small Interfering; Tumor Cells, Cultured

2011
Determination of the phosphorylated metabolites of gemcitabine and of difluorodeoxyuridine by LCMSMS.
    Nucleosides, nucleotides & nucleic acids, 2011, Volume: 30, Issue:12

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Chromatography, Liquid; Cytosol; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Mass Spectrometry; Nucleotides; Phosphorylation

2011
Chemotherapy-induced toxicity is highly heritable in Drosophila melanogaster.
    Pharmacogenetics and genomics, 2012, Volume: 22, Issue:4

    Topics: Animals; Carboplatin; Deoxycytidine; Dose-Response Relationship, Drug; Drosophila melanogaster; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Female; Fertility; Floxuridine; Gemcitabine; High-Throughput Screening Assays; Humans; Methotrexate; Mitomycin; Models, Animal; Neoplasms; Topotecan

2012
Attenuation of phosphorylation by deoxycytidine kinase is key to acquired gemcitabine resistance in a pancreatic cancer cell line: targeted proteomic and metabolomic analyses in PK9 cells.
    Pharmaceutical research, 2012, Volume: 29, Issue:7

    Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Floxuridine; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Metabolomics; Pancreas; Pancreatic Neoplasms; Phosphorylation; Proteomics

2012
Pathway-based pharmacogenomics of gemcitabine pharmacokinetics in patients with solid tumors.
    Pharmacogenomics, 2012, Volume: 13, Issue:9

    Topics: 5'-Nucleotidase; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Cytidine Deaminase; Deoxycytidine; Deoxycytidine Kinase; Equilibrative Nucleoside Transporter 1; Female; Floxuridine; Gemcitabine; Genetic Association Studies; Humans; Male; Metabolic Networks and Pathways; Middle Aged; Neoplasms; Pharmacogenetics; Polymorphism, Single Nucleotide

2012
Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs.
    BMC cancer, 2012, Sep-27, Volume: 12

    Topics: Antineoplastic Agents; Apoptosis; Aquaporin 3; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Size; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; Dose-Response Relationship, Drug; fas Receptor; Floxuridine; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; MCF-7 Cells; Nucleosides; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Up-Regulation

2012
Determination of gemcitabine and its metabolite in extracellular fluid of rat brain tumor by ultra performance liquid chromatography-tandem mass spectrometry using microdialysis sampling after intralesional chemotherapy.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Mar-01, Volume: 919-920

    Topics: Animals; Antimetabolites, Antineoplastic; Brain Chemistry; Brain Neoplasms; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Floxuridine; Gemcitabine; Glioma; Limit of Detection; Linear Models; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tandem Mass Spectrometry

2013
High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC-MS/MS.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2013, Aug-01, Volume: 932

    Topics: Antimetabolites, Antineoplastic; Chromatography, Liquid; Deoxycytidine; Deoxyuridine; Floxuridine; Gemcitabine; Humans; Prodrugs; Sensitivity and Specificity; Tandem Mass Spectrometry

2013
Can thymidine phosphorylase be a predictive marker for gemcitabine and doxifluridine combination chemotherapy in cholangiocarcinoma?: case series.
    Medicine, 2014, Volume: 93, Issue:28

    Topics: Adult; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Cholangiocarcinoma; Deoxycytidine; Drug Therapy, Combination; Fatal Outcome; Female; Floxuridine; Follow-Up Studies; Gemcitabine; Humans; Immunohistochemistry; Middle Aged; Thymidine Phosphorylase; Tomography, X-Ray Computed

2014
Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine.
    The international journal of biochemistry & cell biology, 2015, Volume: 60

    Topics: Cell Line, Tumor; Deoxycytidine; DNA Damage; Enzyme Activation; Floxuridine; Gemcitabine; Humans; Thymidylate Synthase

2015
Preanalytical Stability of Gemcitabine and its Metabolite 2', 2'-Difluoro-2'-Deoxyuridine in Whole Blood-Assessed by Liquid Chromatography Tandem Mass Spectrometry.
    Journal of pharmaceutical sciences, 2015, Volume: 104, Issue:12

    Topics: Antimetabolites, Antineoplastic; Chromatography, Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Tandem Mass Spectrometry

2015
IDO Downregulation Induces Sensitivity to Pemetrexed, Gemcitabine, FK866, and Methoxyamine in Human Cancer Cells.
    PloS one, 2015, Volume: 10, Issue:11

    Topics: Acrylamides; Animals; BRCA2 Protein; Cell Line, Tumor; Clone Cells; Deoxycytidine; DNA Repair; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Induction; Floxuridine; Gemcitabine; Gene Knockdown Techniques; Humans; Hydroxylamines; Indoleamine-Pyrrole 2,3,-Dioxygenase; Mice, SCID; NAD; Pemetrexed; Piperidines; RNA, Small Interfering; Thymidylate Synthase; Xenograft Model Antitumor Assays

2015
Unresectable intrahepatic cholangiocarcinoma: Systemic plus hepatic arterial infusion chemotherapy is associated with longer survival in comparison with systemic chemotherapy alone.
    Cancer, 2016, Mar-01, Volume: 122, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Camptothecin; Cholangiocarcinoma; Deoxycytidine; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Gemcitabine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Male; Middle Aged; Mitomycin; Retrospective Studies; Survival Rate

2016
Sensitive liquid chromatography mass spectrometry (LC-MS) assay reveals novel insights on DNA methylation and incorporation of gemcitabine, its metabolite difluorodeoxyuridine, deoxyuridine, and RX-3117 into DNA.
    Nucleosides, nucleotides & nucleic acids, 2016, Volume: 35, Issue:10-12

    Topics: Cell Line, Tumor; Chromatography, Liquid; Cytidine; Deoxycytidine; DNA; DNA Methylation; Floxuridine; Gemcitabine; Humans; Limit of Detection; Mass Spectrometry; RNA

2016
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.
    Gut, 2018, Volume: 67, Issue:3

    Topics: 5'-Nucleotidase; Actins; Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cytidine Triphosphate; Deoxycytidine; Fibroblasts; Floxuridine; Gemcitabine; Humans; Liver; Liver Neoplasms; Mice; Pancreatic Neoplasms; Primary Cell Culture; Tumor Microenvironment

2018
Effect of nucleoside analogue antimetabolites on the structure of PEO-PPO-PEO micelles investigated by SANS.
    Physical chemistry chemical physics : PCCP, 2017, Jun-21, Volume: 19, Issue:24

    Topics: Antimetabolites; Deoxycytidine; Floxuridine; Fluorouracil; Gemcitabine; Micelles; Neutron Diffraction; Poloxamer; Polyethylene Glycols; Propylene Glycols; Scattering, Small Angle; Transition Temperature; Water

2017
Enzyme-sensitive gemcitabine conjugated albumin nanoparticles as a versatile theranostic nanoplatform for pancreatic cancer treatment.
    Journal of colloid and interface science, 2017, Dec-01, Volume: 507

    Topics: Albumins; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Deoxycytidine; Drug Carriers; Drug Liberation; Floxuridine; Fluorescent Dyes; Gemcitabine; Heterografts; Humans; Indoles; Mice, Inbred BALB C; Nanoparticles; Oligopeptides; Pancreatic Neoplasms; Particle Size; Surface Properties; Theranostic Nanomedicine; Tissue Distribution

2017
Ultra-sensitive LC-MS/MS method for the quantification of gemcitabine and its metabolite 2',2'-difluorodeoxyuridine in human plasma for a microdose clinical trial.
    Journal of pharmaceutical and biomedical analysis, 2018, Mar-20, Volume: 151

    Topics: Chromatography, Liquid; Clinical Trials, Phase I as Topic; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Reproducibility of Results; Tandem Mass Spectrometry

2018
Simultaneous determination of gemcitabine prodrug, gemcitabine and its major metabolite 2', 2'-difluorodeoxyuridine in rat plasma by UFLC-MS/MS.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2018, May-01, Volume: 1084

    Topics: Animals; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Floxuridine; Gemcitabine; Linear Models; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry

2018
Hepatic artery infusion pump for nasopharyngeal carcinoma with liver metastasis.
    Clinical & experimental metastasis, 2020, Volume: 37, Issue:2

    Topics: Adult; Aged; Angiography, Digital Subtraction; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Female; Floxuridine; Follow-Up Studies; Gemcitabine; Hepatic Artery; Humans; Infusion Pumps; Infusions, Intra-Arterial; Kaplan-Meier Estimate; Liver; Liver Neoplasms; Male; Middle Aged; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Retrospective Studies; Treatment Outcome; Vascular Access Devices

2020
Locoregional Therapy Plus Systemic Chemotherapy in Unresectable Intrahepatic Cholangiocarcinoma.
    JAMA oncology, 2020, 06-01, Volume: 6, Issue:6

    Topics: Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Oxaliplatin

2020
Locoregional Therapy Plus Systemic Chemotherapy in Unresectable Intrahepatic Cholangiocarcinoma-Reply.
    JAMA oncology, 2020, 06-01, Volume: 6, Issue:6

    Topics: Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cholangiocarcinoma; Deoxycytidine; Floxuridine; Gemcitabine; Humans; Oxaliplatin

2020
LC-MS/MS method for quantitation of gemcitabine and its metabolite 2',2'-difluoro-2'-deoxyuridine in mouse plasma and brain tissue: Application to a preclinical pharmacokinetic study.
    Journal of pharmaceutical and biomedical analysis, 2021, May-10, Volume: 198

    Topics: Animals; Brain; Chromatography, High Pressure Liquid; Chromatography, Liquid; Deoxycytidine; Floxuridine; Gemcitabine; Mice; Reproducibility of Results; Tandem Mass Spectrometry

2021
Effects of six pyrimidine analogs on the growth of Tetrahymena thermophila and their implications in pyrimidine metabolism.
    PloS one, 2023, Volume: 18, Issue:9

    Topics: Antimetabolites; Cytarabine; Floxuridine; Fluorouracil; Gemcitabine; Nucleosides; Pyrimidines; Tetrahymena thermophila; Thymine; Uracil

2023