Compounds > gemcitabine
Page last updated: 2024-08-24

gemcitabine and cytidine triphosphate

gemcitabine has been researched along with cytidine triphosphate in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (35.29)18.2507
2000's7 (41.18)29.6817
2010's4 (23.53)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bao, H; Furman, PA; McBrayer, TR; Micolochick Steuer, HM; Murakami, E; Obikhod, A; Otto, MJ; Ramesh, M; Schinazi, RF; Stuyver, LJ; Whitaker, T1
Chubb, S; Grindey, GB; Heinemann, V; Hertel, LW; Plunkett, W; Sen, A; Xu, YZ1
Abbruzzese, J; Grunewald, R; Kantarjian, H; Keating, MJ; Plunkett, W; Tarassoff, P1
Heinemann, V; Issels, RD; Plunkett, W; Schulz, L1
Cuddy, DP; Ross, DD1
Chang, EY; Hahn, TM; Hertel, LW; Lawrence, TS; Shewach, DS1
Peters, G; Pinedo, HM; van Haperen, VW; Veerman, G; Vermorken, JB1
Blackstock, AW; Case, LD; Hess, SM; Lightfoot, H; Mitchell, BS; Mukherji, SK; Swarts, SG; Tepper, JE1
Cinatl, J; Doerr, HW; Gröschel, B; Höver, G; Kaufmann, A; Loves, WJ; Noordhuis, P; Peters, GJ1
Airoldi, M; Cattel, L; Delprino, L; Milla, P; Passera, R; Pedani, F1
Goh, BC; Holford, NH; Lee, HS; Lee, SC; Soo, RA; Tham, LS; Wang, LZ1
Leen, R; Medema, J; Rodermond, H; van Bree, C; van Kuilenburg, A1
Barten-Van Rijbroek, AD; Kal, HB; Leen, R; Rodermond, HM; Van Bree, C; Van Kuilenburg, AB1
Bapiro, TE; Cook, N; Frese, KK; Goldgraben, MA; Griffiths, JR; Jacobetz, MA; Jodrell, DI; Madhu, B; Olive, KP; Richards, FM; Smith, DM; Tuveson, DA1
Bapiro, TE; Chen, N; Ellenrieder, V; Frese, KK; Gopinathan, A; Gress, TM; Hessmann, E; Heuchel, R; Jodrell, DI; Johnsen, SA; Kari, V; Klein, L; Li, X; Löhr, JM; Neesse, A; Patzak, MS; Ramu, I; Richards, FM; Verbeke, C1
Ghazaly, E; Peters, GJ; Rizzuto, I1
Beijnen, JH; Derissen, EJB; Huitema, ADR; Rosing, H; Schellens, JHM1

Reviews

1 review(s) available for gemcitabine and cytidine triphosphate

ArticleYear
Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate.
    Pharmacogenomics, 2017, Volume: 18, Issue:9

    Topics: Antimetabolites, Antineoplastic; Biological Transport; Cytidine Triphosphate; Deoxycytidine; Gemcitabine; Humans; Neoplasms

2017

Trials

2 trial(s) available for gemcitabine and cytidine triphosphate

ArticleYear
Pharmacokinetic evaluation of gemcitabine and 2',2'-difluorodeoxycytidine-5'-triphosphate after prolonged infusion in patients affected by different solid tumors.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2006, Volume: 17 Suppl 5

    Topics: Adult; Aged; Cytidine Triphosphate; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Survival Analysis; Time Factors; Treatment Outcome

2006
Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:6

    Topics: Activation, Metabolic; Antimetabolites, Antineoplastic; Breast Neoplasms; Cytidine Triphosphate; Deamination; Deoxycytidine; Female; Floxuridine; Gemcitabine; Humans; Leukocytes, Mononuclear; Phosphorylation; Uridine Triphosphate

2018

Other Studies

14 other study(ies) available for gemcitabine and cytidine triphosphate

ArticleYear
Mechanism of activation of beta-D-2'-deoxy-2'-fluoro-2'-c-methylcytidine and inhibition of hepatitis C virus NS5B RNA polymerase.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:2

    Topics: Antiviral Agents; Catalysis; Deoxycytidine; Hepacivirus; Hepatitis C; Humans; Mutation; Phosphorylation; RNA-Dependent RNA Polymerase; RNA, Viral; Structure-Activity Relationship; Viral Nonstructural Proteins; Virus Replication

2007
Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation.
    Cancer research, 1992, Feb-01, Volume: 52, Issue:3

    Topics: Antimetabolites, Antineoplastic; Cell Line; Cytidine Triphosphate; DCMP Deaminase; Deoxycytidine; Deoxyribonucleotides; Gemcitabine; Humans; Kinetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ribonucleotides

1992
Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (Gemcitabine) administration in leukemia.
    Cancer research, 1990, Nov-01, Volume: 50, Issue:21

    Topics: Adult; Aged; Antimetabolites, Antineoplastic; Cytidine Triphosphate; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intravenous; Leukemia; Male; Middle Aged; Neoplastic Cells, Circulating

1990
Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism.
    Seminars in oncology, 1995, Volume: 22, Issue:4 Suppl 11

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Carbon-Nitrogen Ligases; CHO Cells; Cricetinae; Cytidine Triphosphate; Deoxycytidine; Deoxycytosine Nucleotides; Dinucleoside Phosphates; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gemcitabine; Ligases; Phosphorylation; Ribonucleotide Reductases; Ribonucleotides; RNA; Tissue Distribution

1995
Consequences of 2',2'-difluorodeoxycytidine (gemcitabine) on replicative DNA synthesis in intact HL-60 cells.
    Seminars in oncology, 1995, Volume: 22, Issue:4 Suppl 11

    Topics: Antimetabolites, Antineoplastic; Cytarabine; Cytidine Triphosphate; Deoxycytidine; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; Gemcitabine; Guanosine Triphosphate; Half-Life; HL-60 Cells; Humans; Nucleosides; Peptide Chain Elongation, Translational; Thymine

1995
Radiosensitization of pancreatic cancer cells by 2',2'-difluoro-2'-deoxycytidine.
    International journal of radiation oncology, biology, physics, 1996, Mar-01, Volume: 34, Issue:4

    Topics: Adenosine Triphosphate; Cell Cycle; Cell Survival; Cytidine Triphosphate; Deoxycytidine; Drug Screening Assays, Antitumor; Gemcitabine; Guanosine Triphosphate; Humans; Pancreatic Neoplasms; Radiation-Sensitizing Agents; Thymine Nucleotides; Tumor Cells, Cultured

1996
Regulation of phosphorylation of deoxycytidine and 2',2'-difluorodeoxycytidine (gemcitabine); effects of cytidine 5'-triphosphate and uridine 5'-triphosphate in relation to chemosensitivity for 2',2'-difluorodeoxycytidine.
    Biochemical pharmacology, 1996, Apr-12, Volume: 51, Issue:7

    Topics: Cytidine Deaminase; Cytidine Triphosphate; Deoxycytidine; Deoxycytidine Kinase; Enzyme Inhibitors; Female; Gemcitabine; Humans; Kinetics; Nucleoside Deaminases; Ovarian Neoplasms; Phosphorylation; Tumor Cells, Cultured; Uridine Triphosphate

1996
Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:10

    Topics: Animals; Cell Division; Chromatography, High Pressure Liquid; Cytidine Triphosphate; Deoxycytidine; Deoxycytidine Kinase; Female; Fluorine; Gemcitabine; Gene Expression Regulation, Enzymologic; Gene Transfer Techniques; HT29 Cells; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Neoplasms, Experimental; Xenograft Model Antitumor Assays

2001
3'-Azido-2',3'-dideoxythymidine induced deficiency of thymidine kinases 1, 2 and deoxycytidine kinase in H9 T-lymphoid cells.
    Biochemical pharmacology, 2002, Jul-15, Volume: 64, Issue:2

    Topics: Adenosine Triphosphate; Anti-HIV Agents; Blotting, Western; Cytidine Triphosphate; Deoxycytidine; Deoxycytidine Kinase; Drug Resistance, Microbial; Gemcitabine; HIV-1; Humans; RNA, Messenger; T-Lymphocytes; Thymidine Kinase; Uridine Triphosphate; Zidovudine

2002
Does saturable formation of gemcitabine triphosphate occur in patients?
    Cancer chemotherapy and pharmacology, 2008, Volume: 63, Issue:1

    Topics: Adipose Tissue; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Body Weight; Carboplatin; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase II as Topic; Creatinine; Cytidine Triphosphate; Deoxycytidine; Female; Gemcitabine; Humans; Lung Neoplasms; Male; Middle Aged; Models, Biological; Prodrugs; Prospective Studies; Randomized Controlled Trials as Topic

2008
Cyclopentenyl cytosine increases gemcitabine radiosensitisation in human pancreatic cancer cells.
    British journal of cancer, 2008, Apr-08, Volume: 98, Issue:7

    Topics: Apoptosis; Cell Line, Tumor; Cell Survival; Cytidine; Cytidine Triphosphate; Deoxycytidine; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Gemcitabine; Humans; Lung Neoplasms; Pancreatic Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents

2008
Cyclopentenyl cytosine has biological and anti-tumour activity, but does not enhance the efficacy of gemcitabine and radiation in two animal tumour models.
    International journal of oncology, 2009, Volume: 34, Issue:3

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Combined Modality Therapy; Cytidine; Cytidine Triphosphate; Deoxycytidine; Disease Models, Animal; Drug Synergism; Female; Gemcitabine; Humans; Lung Neoplasms; Mice; Mice, Nude; Middle Aged; Pancreatic Neoplasms; Rats; Rats, Inbred BN

2009
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.
    Cancer chemotherapy and pharmacology, 2011, Volume: 68, Issue:5

    Topics: Animals; Antineoplastic Agents; Calibration; Cytidine Triphosphate; Deoxycytidine; Disease Models, Animal; Floxuridine; Fluorine; Gemcitabine; Humans; Magnetic Resonance Spectroscopy; Mice; Reference Standards; Tandem Mass Spectrometry

2011
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.
    Gut, 2018, Volume: 67, Issue:3

    Topics: 5'-Nucleotidase; Actins; Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cytidine Triphosphate; Deoxycytidine; Fibroblasts; Floxuridine; Gemcitabine; Humans; Liver; Liver Neoplasms; Mice; Pancreatic Neoplasms; Primary Cell Culture; Tumor Microenvironment

2018