gemcitabine has been researched along with cyclopamine in 8 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Du, W; Posner, M; Schmidt, H; Shafaee, Z; Weichselbaum, R | 1 |
| Alvarez, H; Beaty, R; Bedja, D; Dhara, S; Feldmann, G; Fendrich, V; Gabrielson, KL; Iacobuzio-Donahue, C; Jimeno, A; Karikari, C; Maitra, A; Matsui, W; Mullendore, M | 1 |
| Bartenstein, P; Berger, F; D'Haese, JG; Ellwart, JW; Heeschen, C; Hermann, PC; Hidalgo, M; Huber, S; Jauch, KW; Leicht, SF; Mueller, MT; Mustafa, M; Rubio-Viqueira, B; Schoenberg, MH; Witthauer, J | 1 |
| An, Y; Chen, P; Ji, ZL; Jiang, KR; Lu, ZP; Miao, Y; Wie, JS; Wu, JL; Xu, ZK; Yao, J | 1 |
| Bahra, M; Boas-Knoop, S; Esendik, U; Hartmann, W; Heppner, F; Kamphues, C; Koch, A; Lippert, S; Neuhaus, P; Pietsch, T; Schüller, U; Waha, A | 1 |
| Iwasaki, H; Kai, M; Katano, M; Morifuji, Y; Onishi, H; Suyama, K | 1 |
| Cui, X; Li, M; Liu, C; Liu, L; Liu, Z; Long, J; Luo, G; Shi, S; Xiao, Z; Xu, J; Yu, X | 1 |
| Han, L; Jiang, J; Ma, Q; Wang, Z; Wu, Z | 1 |
8 other study(ies) available for gemcitabine and cyclopamine
| Article | Year |
|---|---|
Cyclopamine increases the cytotoxic effects of paclitaxel and radiation but not cisplatin and gemcitabine in Hedgehog expressing pancreatic cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Dose-Response Relationship, Drug; Drug Synergism; Gemcitabine; HCT116 Cells; Hedgehog Proteins; Humans; Paclitaxel; Pancreatic Neoplasms; Radiation, Ionizing; Time Factors; Veratrum Alkaloids | 2006 |
Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Deoxycytidine; Drug Synergism; Gemcitabine; Hedgehog Proteins; Humans; Male; Mice; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Signal Transduction; Tumor Cells, Cultured; Veratrum Alkaloids; Xenograft Model Antitumor Assays | 2007 |
Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.
Topics: AC133 Antigen; Animals; Antigens, CD; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Female; Gemcitabine; Glycoproteins; Hedgehog Proteins; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplastic Stem Cells; Pancreatic Neoplasms; Peptides; Protein Kinases; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Veratrum Alkaloids | 2009 |
Cyclopamine reverts acquired chemoresistance and down-regulates cancer stem cell markers in pancreatic cancer cell lines.
Topics: AC133 Antigen; Antigens, CD; Apoptosis; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biomarkers, Tumor; Carcinoma, Pancreatic Ductal; Deoxycytidine; Down-Regulation; Drug Resistance, Neoplasm; Gemcitabine; Glycoproteins; Hedgehog Proteins; Humans; Hyaluronan Receptors; Neoplasm Proteins; Neoplastic Stem Cells; Oncogene Proteins; Pancreatic Neoplasms; Patched Receptors; Peptides; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Smoothened Receptor; Trans-Activators; Tumor Cells, Cultured; Veratrum Alkaloids; Zinc Finger Protein GLI1 | 2011 |
Combination of hedgehog signaling blockage and chemotherapy leads to tumor reduction in pancreatic adenocarcinomas.
Topics: Adenocarcinoma; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Dose-Response Relationship, Drug; Gemcitabine; Genes, Reporter; Hedgehog Proteins; Humans; Mice; Mice, Nude; Middle Aged; Mutation; Pancreatic Neoplasms; Patched Receptors; Patched-1 Receptor; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Signal Transduction; Time Factors; Transcription Factors; Transfection; Tumor Burden; Veratrum Alkaloids; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1 | 2012 |
Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle Checkpoints; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Female; Flow Cytometry; Fluorouracil; Gemcitabine; Hedgehog Proteins; Humans; Immunoblotting; Mice; Mice, Inbred BALB C; Mice, Nude; Pancreatic Neoplasms; Receptors, G-Protein-Coupled; RNA Interference; Smoothened Receptor; Transcription Factors; Veratrum Alkaloids; Xenograft Model Antitumor Assays; Zinc Finger Protein GLI1 | 2012 |
Highly lymphatic metastatic pancreatic cancer cells possess stem cell-like properties.
Topics: AC133 Antigen; Animals; Antigens, CD; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Gemcitabine; Glycoproteins; Hedgehog Proteins; Humans; Lymphatic Metastasis; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, SCID; MicroRNAs; Neoplastic Stem Cells; Pancreatic Neoplasms; Peptides; Receptors, CXCR4; Veratrum Alkaloids | 2013 |
The inhibition of heme oxygenase-1 enhances the chemosensitivity and suppresses the proliferation of pancreatic cancer cells through the SHH signaling pathway.
Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Drug Resistance, Neoplasm; Gemcitabine; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Hedgehog Proteins; Heme Oxygenase-1; Humans; Pancreatic Neoplasms; Protoporphyrins; Signal Transduction; Up-Regulation; Veratrum Alkaloids | 2018 |