gemcitabine has been researched along with alvocidib in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (58.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Albanese, C; Alzani, R; Avanzi, N; Ballinari, D; Bensimon, A; Brotherton, D; Cattoni, M; Ciavolella, A; Croci, V; Fiorentini, F; Healy, S; Isacchi, A; Marchesi, V; Menichincheri, M; Molinari, A; Moll, J; Montagnoli, A; Patton, V; Pesenti, E; Rainoldi, S; Santocanale, C; Sola, F; Tenca, P; Tibolla, M; Valsasina, B; Vanotti, E; Volpi, D | 1 |
| Bandgar, BP; Bodade, RG; Gawande, SS; Khobragade, CN; Totre, JV | 1 |
| Bandgar, BP; Gawande, SS | 1 |
| Karthikeyan, S; Palakshi Reddy, B; Rajesh, K; Suchetha Kumari, N; Venkat Ragavan, R; Vijayakumar, V | 1 |
| Chaniara, RS; Dodia, NM; Khunt, RC; Shah, AK; Upadhyay, KD | 1 |
| Jung, CP; Motwani, MV; Schwartz, GK | 1 |
| Matranga, CB; Shapiro, GI | 1 |
| Cory, AH; Cory, JG | 1 |
| Ali, S; Aranha, O; El-Rayes, BF; Philip, PA; Sarkar, FH | 1 |
| Fornier, MN; Hudis, C; Kelsen, DP; Lefkowitz, R; O'Reilly, E; Patil, S; Rathkopf, D; Schwartz, GK; Shah, M; Tse, AN | 1 |
| Chyi Lee, F; Fekrazad, HM; Rabinowitz, I; Royce, M; Smith, HO; Verschraegen, CF | 1 |
2 trial(s) available for gemcitabine and alvocidib
| Article | Year |
|---|---|
Phase I dose-finding study of weekly docetaxel followed by flavopiridol for patients with advanced solid tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Docetaxel; Drug Administration Schedule; Drug Resistance, Neoplasm; Drug Synergism; Female; Flavonoids; Gemcitabine; Humans; Male; Middle Aged; Neoplasms; Piperidines; Taxoids; Treatment Outcome | 2007 |
A phase I study of flavopiridol in combination with gemcitabine and irinotecan in patients with metastatic cancer.
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Flavonoids; Gemcitabine; Humans; Irinotecan; Life Expectancy; Male; Middle Aged; Neoplasm Metastasis; Patient Selection; Piperidines | 2010 |
10 other study(ies) available for gemcitabine and alvocidib
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Cycle Proteins; Cell Death; Cell Line, Tumor; Cell Proliferation; DNA; DNA Replication; Dose-Response Relationship, Drug; Fibroblasts; HeLa Cells; Humans; Mice; Mice, Nude; Mice, SCID; Minichromosome Maintenance Complex Component 2; Molecular Structure; Nuclear Proteins; Phosphorylation; Piperidones; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Pyrroles; Rats; Small Molecule Libraries; Structure-Activity Relationship; Xenograft Model Antitumor Assays | 2008 |
Synthesis and biological evaluation of simple methoxylated chalcones as anticancer, anti-inflammatory and antioxidant agents.
Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Antioxidants; Cell Line, Tumor; Chalcones; Drug Screening Assays, Antitumor; Humans; Structure-Activity Relationship | 2010 |
Synthesis and biological screening of a combinatorial library of beta-chlorovinyl chalcones as anticancer, anti-inflammatory and antimicrobial agents.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Cell Line; Chalcones; Combinatorial Chemistry Techniques; Humans; Microbial Sensitivity Tests; Small Molecule Libraries | 2010 |
Simple, fast and efficient synthesis of β-keto esters from the esters of heteroaryl compounds, its antimicrobial study and cytotoxicity towards various cancer cell lines.
Topics: Acetates; Anti-Infective Agents; Antineoplastic Agents; Bacteria; Cell Line, Tumor; Cell Proliferation; Cell Survival; Esters; Fungi; Humans; Inhibitory Concentration 50; Ketones; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Solvents; Structure-Activity Relationship | 2012 |
Synthesis and Biological Screening of Pyrano[3,2-
Topics: | 2018 |
Flavopiridol increases sensitization to gemcitabine in human gastrointestinal cancer cell lines and correlates with down-regulation of ribonucleotide reductase M2 subunit.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cyclin D1; Cyclin E; Cysteine Endopeptidases; Cytochrome c Group; Deoxycytidine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Drug Synergism; E2F Transcription Factors; E2F1 Transcription Factor; Enzyme Inhibitors; Flavonoids; Gastrointestinal Neoplasms; Gemcitabine; Gene Expression Regulation, Enzymologic; Humans; Mitochondria; Multienzyme Complexes; Phosphorylation; Piperidines; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Protein Subunits; Retinoblastoma Protein; Ribonucleotide Reductases; RNA, Messenger; Thymidine; Transcription Factors; Tritium; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2001 |
Selective sensitization of transformed cells to flavopiridol-induced apoptosis following recruitment to S-phase.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bronchi; Carcinoma, Non-Small-Cell Lung; Cell Cycle; Cell Line, Transformed; Cisplatin; Cyclin-Dependent Kinases; Deoxycytidine; DNA; DNA, Neoplasm; Drug Interactions; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Flavonoids; Gemcitabine; Humans; Lung Neoplasms; Piperidines; S Phase; Tumor Cells, Cultured | 2002 |
Gemcitabine-induced apoptosis in a drug-resistant mouse leukemia L1210 cell line that does not express p53.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle; Cell Division; Cell Line, Tumor; Deoxyadenosines; Deoxycytidine; Drug Resistance, Neoplasm; Flavonoids; Gemcitabine; Leukemia L1210; Methotrexate; Mice; Piperidines; Tumor Suppressor Protein p53 | 2004 |
Sequence dependent potentiation of gemcitabine by flavopiridol in human breast cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Drug Synergism; Female; Flavonoids; Gemcitabine; Humans; Piperidines | 2005 |