gemcitabine has been researched along with 2',2'-difluorodeoxycytidine 5'-triphosphate in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (20.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chubb, S; Grindey, GB; Heinemann, V; Hertel, LW; Plunkett, W; Sen, A; Xu, YZ | 1 |
| Abbruzzese, J; Grunewald, R; Kantarjian, H; Keating, MJ; Plunkett, W; Tarassoff, P | 1 |
| Blackstock, AW; Case, LD; Hess, SM; Lightfoot, H; Mitchell, BS; Mukherji, SK; Swarts, SG; Tepper, JE | 1 |
| Airoldi, M; Cattel, L; Delprino, L; Milla, P; Passera, R; Pedani, F | 1 |
| Goh, BC; Holford, NH; Lee, HS; Lee, SC; Soo, RA; Tham, LS; Wang, LZ | 1 |
| Bapiro, TE; Cook, N; Frese, KK; Goldgraben, MA; Griffiths, JR; Jacobetz, MA; Jodrell, DI; Madhu, B; Olive, KP; Richards, FM; Smith, DM; Tuveson, DA | 1 |
| Bapiro, TE; Chen, N; Ellenrieder, V; Frese, KK; Gopinathan, A; Gress, TM; Hessmann, E; Heuchel, R; Jodrell, DI; Johnsen, SA; Kari, V; Klein, L; Li, X; Löhr, JM; Neesse, A; Patzak, MS; Ramu, I; Richards, FM; Verbeke, C | 1 |
| Ghazaly, E; Peters, GJ; Rizzuto, I | 1 |
| Beijnen, JH; Derissen, EJB; Huitema, ADR; Rosing, H; Schellens, JHM | 1 |
| Bearne, SL; Gillis, TD; Holyoak, T; McCluskey, GD; McLeod, MJ; Tran, N | 1 |
1 review(s) available for gemcitabine and 2',2'-difluorodeoxycytidine 5'-triphosphate
| Article | Year |
|---|---|
Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Cytidine Triphosphate; Deoxycytidine; Gemcitabine; Humans; Neoplasms | 2017 |
2 trial(s) available for gemcitabine and 2',2'-difluorodeoxycytidine 5'-triphosphate
| Article | Year |
|---|---|
Pharmacokinetic evaluation of gemcitabine and 2',2'-difluorodeoxycytidine-5'-triphosphate after prolonged infusion in patients affected by different solid tumors.
Topics: Adult; Aged; Cytidine Triphosphate; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Survival Analysis; Time Factors; Treatment Outcome | 2006 |
Intracellular pharmacokinetics of gemcitabine, its deaminated metabolite 2',2'-difluorodeoxyuridine and their nucleotides.
Topics: Activation, Metabolic; Antimetabolites, Antineoplastic; Breast Neoplasms; Cytidine Triphosphate; Deamination; Deoxycytidine; Female; Floxuridine; Gemcitabine; Humans; Leukocytes, Mononuclear; Phosphorylation; Uridine Triphosphate | 2018 |
7 other study(ies) available for gemcitabine and 2',2'-difluorodeoxycytidine 5'-triphosphate
| Article | Year |
|---|---|
Cellular elimination of 2',2'-difluorodeoxycytidine 5'-triphosphate: a mechanism of self-potentiation.
Topics: Antimetabolites, Antineoplastic; Cell Line; Cytidine Triphosphate; DCMP Deaminase; Deoxycytidine; Deoxyribonucleotides; Gemcitabine; Humans; Kinetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ribonucleotides | 1992 |
Pharmacologically directed design of the dose rate and schedule of 2',2'-difluorodeoxycytidine (Gemcitabine) administration in leukemia.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Cytidine Triphosphate; Deoxycytidine; Drug Administration Schedule; Female; Gemcitabine; Humans; Infusions, Intravenous; Leukemia; Male; Middle Aged; Neoplastic Cells, Circulating | 1990 |
Tumor uptake and elimination of 2',2'-difluoro-2'-deoxycytidine (gemcitabine) after deoxycytidine kinase gene transfer: correlation with in vivo tumor response.
Topics: Animals; Cell Division; Chromatography, High Pressure Liquid; Cytidine Triphosphate; Deoxycytidine; Deoxycytidine Kinase; Female; Fluorine; Gemcitabine; Gene Expression Regulation, Enzymologic; Gene Transfer Techniques; HT29 Cells; Humans; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Neoplasms, Experimental; Xenograft Model Antitumor Assays | 2001 |
Does saturable formation of gemcitabine triphosphate occur in patients?
Topics: Adipose Tissue; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Body Weight; Carboplatin; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase II as Topic; Creatinine; Cytidine Triphosphate; Deoxycytidine; Female; Gemcitabine; Humans; Lung Neoplasms; Male; Middle Aged; Models, Biological; Prodrugs; Prospective Studies; Randomized Controlled Trials as Topic | 2008 |
A novel method for quantification of gemcitabine and its metabolites 2',2'-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC-MS/MS: comparison with (19)F NMR spectroscopy.
Topics: Animals; Antineoplastic Agents; Calibration; Cytidine Triphosphate; Deoxycytidine; Disease Models, Animal; Floxuridine; Fluorine; Gemcitabine; Humans; Magnetic Resonance Spectroscopy; Mice; Reference Standards; Tandem Mass Spectrometry | 2011 |
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer.
Topics: 5'-Nucleotidase; Actins; Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cytidine Triphosphate; Deoxycytidine; Fibroblasts; Floxuridine; Gemcitabine; Humans; Liver; Liver Neoplasms; Mice; Pancreatic Neoplasms; Primary Cell Culture; Tumor Microenvironment | 2018 |
A metal-dependent conformational change provides a structural basis for the inhibition of CTP synthase by gemcitabine-5'-triphosphate.
Topics: Adenosine Triphosphate; Carbon-Nitrogen Ligases; Escherichia coli; Gemcitabine; Kinetics; Nucleotides | 2023 |