geldanamycin and trimethylenediamine

geldanamycin has been researched along with trimethylenediamine* in 1 studies

Other Studies

1 other study(ies) available for geldanamycin and trimethylenediamine

Article	Year
Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems. Bioorganic & medicinal chemistry letters, 2001, Aug-20, Volume: 11, Issue:16 The 17-methoxy group of geldanamycin was substituted with 1,3-diaminopropane and 1,3-diamino-2-hydroxypropane to introduce a primary amino group useful for conjugation with targeting moieties and drug carriers. We have developed a procedure that has provided improved yield and reproducibility of the syntheses. Both geldanamycin derivatives demonstrated antiproliferative activity towards the human ovarian carcinoma cell line, A2780. Topics: Antibiotics, Antineoplastic; Benzoquinones; Diamines; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Lactams, Macrocyclic; Quinones; Tumor Cells, Cultured	2001

Article

Year

Improved synthesis and evaluation of 17-substituted aminoalkylgeldanamycin derivatives applicable to drug delivery systems.

Bioorganic & medicinal chemistry letters, 2001, Aug-20, Volume: 11, Issue:16

The 17-methoxy group of geldanamycin was substituted with 1,3-diaminopropane and 1,3-diamino-2-hydroxypropane to introduce a primary amino group useful for conjugation with targeting moieties and drug carriers. We have developed a procedure that has provided improved yield and reproducibility of the syntheses. Both geldanamycin derivatives demonstrated antiproliferative activity towards the human ovarian carcinoma cell line, A2780.

Topics: Antibiotics, Antineoplastic; Benzoquinones; Diamines; Drug Carriers; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Lactams, Macrocyclic; Quinones; Tumor Cells, Cultured

2001