Page last updated: 2024-09-03

gefitinib and rofecoxib

gefitinib has been researched along with rofecoxib in 7 studies

Compound Research Comparison

Studies (gefitinib)	Trials (gefitinib)	Recent Studies (post-2010) (gefitinib)	Studies (rofecoxib)	Trials (rofecoxib)	Recent Studies (post-2010) (rofecoxib)
5,231	566	2,919	1,914	307	163

Protein Interaction Comparison

Protein	Taxonomy	rofecoxib (IC50)
Prostaglandin G/H synthase 2	Bos taurus (cattle)	0.43
Cytochrome c oxidase subunit 2	Homo sapiens (human)	1.51
Prostaglandin G/H synthase 1	Ovis aries (sheep)	0.5
Seed linoleate 13S-lipoxygenase-1	Glycine max (soybean)	0.5
Calpain-2 catalytic subunit	Homo sapiens (human)	0.02
Prostaglandin G/H synthase 1	Homo sapiens (human)	1.8
Prostaglandin G/H synthase 2	Homo sapiens (human)	0.3602
Prostaglandin G/H synthase 2	Rattus norvegicus (Norway rat)	0.76
Prostaglandin G/H synthase 2	Ovis aries (sheep)	0.486
Prostaglandin G/H synthase 2	Mus musculus (house mouse)	0.036
Sodium-dependent serotonin transporter	Macaca mulatta (Rhesus monkey)	0.5

Research

Studies (7)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (42.86)	29.6817
2010's	4 (57.14)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andricopulo, AD; Moda, TL; Montanari, CA	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Botwood, N; Carbone, D; Danson, S; Dunlop, D; O'Byrne, KJ; Ranson, M; Taguchi, F	1
Baldi, A; Canino, C; Cardillo, I; Galati, R; Sacchi, A; Stoppoloni, D; Verdina, A	1

Trials

1 trial(s) available for gefitinib and rofecoxib

Article	Year
Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Aug-01, Volume: 25, Issue:22 Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Disease Progression; Drug Administration Schedule; Female; Gefitinib; Humans; Lactones; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Proteomics; Quinazolines; Sulfones; Survival Rate; Treatment Outcome	2007

Article

Year

Combination therapy with gefitinib and rofecoxib in patients with platinum-pretreated relapsed non small-cell lung cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2007, Aug-01, Volume: 25, Issue:22

Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Disease Progression; Drug Administration Schedule; Female; Gefitinib; Humans; Lactones; Lung Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Proteomics; Quinazolines; Sulfones; Survival Rate; Treatment Outcome

2007

Other Studies

6 other study(ies) available for gefitinib and rofecoxib

Article	Year
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Top 10 health stories of 2004. Harvard health letter, 2004, Volume: 30, Issue:2 Topics: Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antidepressive Agents; Antineoplastic Agents; Biomedical Research; Cholesterol, LDL; Cloning, Organism; Coronary Disease; Delivery of Health Care; Dementia; Gefitinib; Humans; Influenza Vaccines; Insurance, Health; Lactones; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Quinazolines; Registries; Sulfones; Walking	2004
Synergistic effect of gefitinib and rofecoxib in mesothelioma cells. Molecular cancer, 2010, Feb-02, Volume: 9 Topics: Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclooxygenase 2; Drug Synergism; ErbB Receptors; Gefitinib; Humans; Lactones; Mesothelioma; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Signal Transduction; Sulfones	2010