Page last updated: 2024-09-03

gefitinib and raltitrexed

gefitinib has been researched along with raltitrexed in 6 studies

Compound Research Comparison

Studies
(gefitinib)
Trials
(gefitinib)
Recent Studies (post-2010)
(gefitinib)
Studies
(raltitrexed)
Trials
(raltitrexed)
Recent Studies (post-2010) (raltitrexed)
5,2315662,919580143121

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)raltitrexed (IC50)
Thymidylate synthase Escherichia coli7.0667
Dihydrofolate reductaseHomo sapiens (human)1.8578
Thymidylate synthaseLacticaseibacillus casei8.2667
Thymidylate synthaseHomo sapiens (human)1.208
Thymidylate synthaseMus musculus (house mouse)0.67
Thymidylate synthaseEscherichia coli K-122.32
Dihydrofolate reductaseEscherichia coli K-122.32
Folate receptor betaHomo sapiens (human)0.384
Folate receptor alphaHomo sapiens (human)0.015
Non-receptor tyrosine-protein kinase TYK2Homo sapiens (human)0.26
Reduced folate transporterHomo sapiens (human)0.0063
Thymidylate synthase Rattus norvegicus (Norway rat)0.9
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii1.7956
Proton-coupled folate transporterHomo sapiens (human)0.0995

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Benfenati, E; Raska, I; Toropov, AA; Toropova, AP1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bansal, R; Malhotra, A1
Bovio, H; de Sande González, L; García-Foncillas, J; García-Girón, C; García-López, JL; Lacave, AJ; Peláez, I; Reboredo, M; Valladares, M; Viéitez, JM1
Cassidy, J; Hochster, H1

Reviews

2 review(s) available for gefitinib and raltitrexed

ArticleYear
Therapeutic progression of quinazolines as targeted chemotherapeutic agents.
    European journal of medicinal chemistry, 2021, Feb-05, Volume: 211

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Enzyme Inhibitors; Humans; Molecular Structure; Neoplasms; Quinazolines

2021
New oxaliplatin-based combinations in the treatment of colorectal cancer.
    Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland, 2003, Volume: 5 Suppl 3

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Boronic Acids; Bortezomib; Camptothecin; Capecitabine; Cetuximab; Colorectal Neoplasms; Deoxycytidine; Fluorouracil; Gefitinib; Humans; Irinotecan; Mitomycin; Organoplatinum Compounds; Oxaliplatin; Pyrazines; Quinazolines; Thiophenes

2003

Trials

1 trial(s) available for gefitinib and raltitrexed

ArticleYear
A randomized phase II study of raltitrexed and gefitinib versus raltitrexed alone as second line chemotherapy in patients with colorectal cancer. (1839IL/0143).
    Investigational new drugs, 2011, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Colorectal Neoplasms; Demography; Female; Gefitinib; Humans; Male; Middle Aged; Quinazolines; Survival Analysis; Thiophenes; Treatment Outcome; Young Adult

2011

Other Studies

3 other study(ies) available for gefitinib and raltitrexed

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:4

    Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013