Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and pp242

gefitinib has been researched along with pp242 in 3 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(pp242)		Trials
(pp242)		Recent Studies (post-2010) (pp242)
5,2315662,919102098

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)pp242 (IC50)
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoformHomo sapiens (human)1.8085
Tyrosine-protein kinase ABL1Homo sapiens (human)2.502
Proto-oncogene tyrosine-protein kinase SrcGallus gallus (chicken)2.6263
Epidermal growth factor receptorHomo sapiens (human)4.4
Tyrosine-protein kinase HCKHomo sapiens (human)2.4678
Platelet-derived growth factor receptor betaHomo sapiens (human)2.6263
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)2.49
Vascular endothelial growth factor receptor 2Homo sapiens (human)2.5011
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoformHomo sapiens (human)1.9352
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoformHomo sapiens (human)1.174
Serine/threonine-protein kinase mTORHomo sapiens (human)1.4284
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)1.3
Ephrin type-B receptor 4Homo sapiens (human)2.7122
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)1.8292
Receptor protein-tyrosine kinase Homo sapiens (human)2.6263
Rapamycin-insensitive companion of mTORHomo sapiens (human)0.08
Regulatory-associated protein of mTORHomo sapiens (human)0.008
Target of rapamycin complex 2 subunit MAPKAP1Homo sapiens (human)0.08
Target of rapamycin complex subunit LST8Homo sapiens (human)0.044
Phosphatidylinositol 4-kinase betaHomo sapiens (human)0.408

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Aizenstein, B; Apsel, B; Blair, JA; Feldman, ME; Gonzalez, B; Hoffman, R; Knight, ZA; Nazif, TM; Shokat, KM; Williams, RL1
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Ebata, T; Ishiwata, T; Iwama, A; Iwasawa, S; Koide, S; Kurimoto, R; Sekine, I; Tada, Y; Takiguchi, Y; Tatsumi, K1

Other Studies

3 other study(ies) available for gefitinib and pp242

ArticleYear
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.
    Nature chemical biology, 2008, Volume: 4, Issue:11

    Topics: Amino Acid Sequence; Antineoplastic Agents; Apoptosis; Blotting, Western; Catalytic Domain; Cell Proliferation; Cells, Cultured; Crystallography, X-Ray; Drug Delivery Systems; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Fusion Proteins, bcr-abl; Humans; Inhibitory Concentration 50; Models, Molecular; Molecular Sequence Data; Molecular Structure; Phosphoinositide-3 Kinase Inhibitors; Protein Kinases; Protein Subunits; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Sequence Alignment; Signal Transduction; TOR Serine-Threonine Kinases

2008
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Drug resistance originating from a TGF-β/FGF-2-driven epithelial-to-mesenchymal transition and its reversion in human lung adenocarcinoma cell lines harboring an EGFR mutation.
    International journal of oncology, 2016, Volume: 48, Issue:5

    Topics: Adenocarcinoma; Adenocarcinoma of Lung; Antineoplastic Agents; B7-H1 Antigen; Cell Line, Tumor; Cell Survival; Cisplatin; Dimethyl Sulfoxide; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Fibroblast Growth Factor 2; Gefitinib; Gene Expression Regulation, Neoplastic; Humans; Indoles; Lung Neoplasms; Metformin; Mutation; Purines; Quinazolines; Transforming Growth Factor beta

2016