Page last updated: 2024-09-03

gefitinib and podophyllotoxin

gefitinib has been researched along with podophyllotoxin in 5 studies

Compound Research Comparison

Studies
(gefitinib)
Trials
(gefitinib)
Recent Studies (post-2010)
(gefitinib)
Studies
(podophyllotoxin)
Trials
(podophyllotoxin)
Recent Studies (post-2010) (podophyllotoxin)
5,2315662,9193,119226782

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)podophyllotoxin (IC50)
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)2.145
Tubulin alpha-1A chainSus scrofa (pig)0.6733
Tubulin beta chainSus scrofa (pig)0.622
Glucocorticoid receptorHomo sapiens (human)0.014
Tubulin beta-4A chainHomo sapiens (human)1.7233
Tubulin beta chainHomo sapiens (human)1.7233
Cytochrome P450 3A4Homo sapiens (human)0.6
Tubulin alpha-3C chainHomo sapiens (human)1.7233
Cytochrome P450 2C9 Homo sapiens (human)4
Cytochrome P450 2C19Homo sapiens (human)5
Tubulin alpha-1B chainHomo sapiens (human)1.7233
Tubulin alpha-4A chainHomo sapiens (human)1.7233
Tubulin beta-4B chainHomo sapiens (human)1.7233
Tubulin beta-3 chainHomo sapiens (human)1.7233
Tubulin beta-2A chainHomo sapiens (human)1.7233
Tubulin beta-8 chainHomo sapiens (human)1.7233
Calcium-activated potassium channel subunit alpha-1Rattus norvegicus (Norway rat)0.56
Tubulin beta-2B chainBos taurus (cattle)0.8685
Tubulin alpha-3E chainHomo sapiens (human)1.7233
Tubulin alpha-1A chainHomo sapiens (human)1.7233
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)0.907
Similar to alpha-tubulin isoform 1 Bos taurus (cattle)0.7744
Tubulin alpha-1C chainHomo sapiens (human)1.7233
Tubulin beta-6 chainHomo sapiens (human)1.7233
Tubulin beta-2B chainHomo sapiens (human)1.7233
Tubulin beta-1 chainHomo sapiens (human)1.7233

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Cherpelis, B; Rudnick, EW; Thareja, S1
Chae, JI; Cho, SS; Kim, E; Kwak, AW; Lee, MH; Liu, K; Oh, HN; Shim, JH; Yoon, G1
Chae, JI; Cho, SS; Kim, E; Kim, HS; Kwak, AW; Lee, MH; Oh, HN; Seo, JH; Shim, JH; Yoon, G1

Reviews

1 review(s) available for gefitinib and podophyllotoxin

ArticleYear
Oral therapy for nonmelanoma skin cancer in patients with advanced disease and large tumor burden: a review of the literature with focus on a new generation of targeted therapies.
    International journal of dermatology, 2016, Volume: 55, Issue:3

    Topics: Administration, Oral; Anilides; Antineoplastic Agents; Biphenyl Compounds; Capecitabine; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; ErbB Receptors; Erlotinib Hydrochloride; Fluorouracil; Gefitinib; Hedgehog Proteins; Molecular Targeted Therapy; Phthalazines; Podophyllotoxin; Pyridines; Quinazolines; Receptor, IGF Type 1; Retinoids; Skin Neoplasms; Tumor Burden

2016

Other Studies

4 other study(ies) available for gefitinib and podophyllotoxin

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Targeted inhibition of c-MET by podophyllotoxin promotes caspase-dependent apoptosis and suppresses cell growth in gefitinib-resistant non-small cell lung cancer cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2021, Volume: 80

    Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Molecular Docking Simulation; Molecular Targeted Therapy; Podophyllotoxin; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-met

2021
Deoxypodophyllotoxin Inhibits Cell Growth and Induces Apoptosis by Blocking EGFR and MET in Gefitinib-Resistant Non-Small Cell Lung Cancer.
    Journal of microbiology and biotechnology, 2021, Apr-28, Volume: 31, Issue:4

    Topics: Antineoplastic Agents; Apiaceae; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Drugs, Chinese Herbal; ErbB Receptors; Gefitinib; Humans; Lung Neoplasms; Membrane Potential, Mitochondrial; Podophyllotoxin; Proto-Oncogene Proteins c-met; Signal Transduction

2021