Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and pd 173074

gefitinib has been researched along with pd 173074 in 4 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(pd 173074)		Trials
(pd 173074)		Recent Studies (post-2010) (pd 173074)
5,2315662,9191600106

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)pd 173074 (IC50)
Platelet-derived growth factor receptor betaMus musculus (house mouse)0.028
Fibroblast growth factor receptor 1Homo sapiens (human)0.0217
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.028
Vascular endothelial growth factor receptor 1 Homo sapiens (human)0.19
Fibroblast growth factor receptor 2Homo sapiens (human)0.013
Fibroblast growth factor receptor 4Homo sapiens (human)0.5337
Fibroblast growth factor receptor 3Homo sapiens (human)0.0268
Vascular endothelial growth factor receptor 3Homo sapiens (human)0.19
Vascular endothelial growth factor receptor 2Homo sapiens (human)0.1325

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Arai, D; Betsuyaku, T; Hamamoto, J; Ikemura, S; Ishioka, K; Nakayama, S; Naoki, K; Ohgino, K; Sato, T; Satomi, R; Soejima, K; Terai, H; Yasuda, H; Yoda, S1
Ashworth, A; Campbell, J; Herrera-Abreu, MT; Knowles, MA; Pearson, A; Shnyder, SD; Turner, NC1

Other Studies

4 other study(ies) available for gefitinib and pd 173074

ArticleYear
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Dec-18, Volume: 104, Issue:51

    Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases

2007
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Activation of the FGF2-FGFR1 autocrine pathway: a novel mechanism of acquired resistance to gefitinib in NSCLC.
    Molecular cancer research : MCR, 2013, Volume: 11, Issue:7

    Topics: Apoptosis; Autocrine Communication; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Clone Cells; Drug Resistance, Neoplasm; Drug Synergism; ErbB Receptors; Fibroblast Growth Factor 2; Gefitinib; Humans; Lung Neoplasms; Models, Biological; Pyrimidines; Quinazolines; Receptor, Fibroblast Growth Factor, Type 1; RNA, Small Interfering; Signal Transduction

2013
Parallel RNA interference screens identify EGFR activation as an escape mechanism in FGFR3-mutant cancer.
    Cancer discovery, 2013, Volume: 3, Issue:9

    Topics: Animals; Cell Line, Tumor; Dasatinib; ErbB Receptors; Gefitinib; Heterografts; High-Throughput Screening Assays; Humans; MAP Kinase Signaling System; Mice; Neoplasm Transplantation; Neoplasms; Protein Kinase Inhibitors; Pyrimidines; Quinazolines; Receptor, Fibroblast Growth Factor, Type 3; RNA Interference; RNA, Small Interfering; Signal Transduction; Thiazoles

2013