Page last updated: 2024-09-03

gefitinib and pci 32765

gefitinib has been researched along with pci 32765 in 8 studies

Compound Research Comparison

Studies
(gefitinib)
Trials
(gefitinib)
Recent Studies (post-2010)
(gefitinib)
Studies
(pci 32765)
Trials
(pci 32765)
Recent Studies (post-2010) (pci 32765)
5,2315662,9191,9262431,895

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)pci 32765 (IC50)
Testosterone 17-beta-dehydrogenase 3Rattus norvegicus (Norway rat)0.0028
Solute carrier family 22 member 3Homo sapiens (human)7.9
Epidermal growth factor receptorHomo sapiens (human)0.0402
Receptor tyrosine-protein kinase erbB-2Homo sapiens (human)0.0104
Cytochrome P450 1A2Homo sapiens (human)0.019
Tyrosine-protein kinase LckHomo sapiens (human)0.018
Tyrosine-protein kinase FynHomo sapiens (human)0.096
Macrophage colony-stimulating factor 1 receptorHomo sapiens (human)5.545
Tyrosine-protein kinase YesHomo sapiens (human)0.0065
Tyrosine-protein kinase LynHomo sapiens (human)0.2
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)0.0262
Tyrosine-protein kinase HCKHomo sapiens (human)0.0095
Cytochrome P450 3A4Homo sapiens (human)0.089
Tyrosine-protein kinase FgrHomo sapiens (human)0.0021
Cytochrome P450 2C8Homo sapiens (human)3.9595
Cytochrome P450 2D6Homo sapiens (human)0.0769
Cytochrome P450 2C9 Homo sapiens (human)6.0643
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)0.0768
Cytochrome P450 2B6Homo sapiens (human)0.101
Cytochrome P450 2C19Homo sapiens (human)0.0769
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)0.073
Tyrosine-protein kinase CSKHomo sapiens (human)0.0023
Tyrosine-protein kinase TecHomo sapiens (human)0.0092
Tyrosine-protein kinase TXKHomo sapiens (human)0.0025
Tyrosine-protein kinase FRKHomo sapiens (human)0.0541
Tyrosine-protein kinase BlkHomo sapiens (human)0.0004
Cytoplasmic tyrosine-protein kinase BMXHomo sapiens (human)0.002
Tyrosine-protein kinase JAK3Homo sapiens (human)0.0411
Tyrosine-protein kinase BTKHomo sapiens (human)0.0422
Tyrosine-protein kinase ITK/TSKHomo sapiens (human)0.0471
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)4.4
Protein-tyrosine kinase 6Homo sapiens (human)0.018
Receptor tyrosine-protein kinase erbB-4Homo sapiens (human)0.0066
Nuclear receptor subfamily 4 group A member 3Homo sapiens (human)0.078
Peroxiredoxin-like 2AHomo sapiens (human)0.9
Platelet glycoprotein VIHomo sapiens (human)0.12

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (50.00)24.3611
2020's4 (50.00)2.80

Authors

AuthorsStudies
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1
Baumann, M; Becker, C; Engel, J; Goebel, L; Günther, G; Hengstler, JG; Hennes, E; Keul, M; Lategahn, J; Müller, H; Rauh, D; Schultz-Fademrecht, C; Smith, S; Tumbrink, HL; Unger, A1
Aiche, S; Bassermann, F; Becker, W; Canevari, G; Casale, E; Depaolini, SR; Ehrlich, HC; Felder, ER; Feuchtinger, A; Garz, AK; Gohlke, BO; Götze, K; Greif, PA; Hahne, H; Heinzlmeir, S; Helm, D; Huenges, J; Jeremias, I; Kayser, G; Klaeger, S; Koch, H; Koenig, PA; Kramer, K; Kuster, B; Médard, G; Meng, C; Petzoldt, S; Polzer, H; Preissner, R; Qiao, H; Reinecke, M; Reiter, K; Rueckert, L; Ruland, J; Ruprecht, B; Schlegl, J; Schmidt, T; Schneider, S; Schoof, M; Spiekermann, K; Tõnisson, N; Vick, B; Vooder, T; Walch, A; Wilhelm, M; Wu, Z; Zecha, J; Zolg, DP1
Chen, L; Li, Y; Liu, K; Ma, T; Ma, X; Sun, H; Sun, X; Wang, C; Zheng, X; Zhu, Y1
Ding, K; Lu, X; Smaill, JB1
Bharate, SB; Raghuvanshi, R1
Chen, XB; Wang, S; Wang, SQ; Yu, B; Yuan, XH; Zhao, W1
Danilov, AV; Hamilton, BJ; Jones, JD; Rigby, WFC; Skopelja-Gardner, S1

Reviews

2 review(s) available for gefitinib and pci 32765

ArticleYear
Medicinal Chemistry Strategies for the Development of Kinase Inhibitors Targeting Point Mutations.
    Journal of medicinal chemistry, 2020, 10-08, Volume: 63, Issue:19

    Topics: Chemistry, Pharmaceutical; Humans; Point Mutation; Protein Kinase Inhibitors

2020
FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application.
    European journal of medicinal chemistry, 2021, Mar-15, Volume: 214

    Topics: Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Humans; Molecular Structure; Neoplasms; Pyrimidines; United States; United States Food and Drug Administration

2021

Other Studies

6 other study(ies) available for gefitinib and pci 32765

ArticleYear
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013
Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
    Journal of medicinal chemistry, 2017, 09-28, Volume: 60, Issue:18

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lung Neoplasms; Male; Mice; Molecular Docking Simulation; Point Mutation; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines

2017
The target landscape of clinical kinase drugs.
    Science (New York, N.Y.), 2017, 12-01, Volume: 358, Issue:6367

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cytokines; Drug Discovery; fms-Like Tyrosine Kinase 3; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Mice; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Proteomics; Xenograft Model Antitumor Assays

2017
Synthesis and biological activity of thieno[3,2-d]pyrimidines as potent JAK3 inhibitors for the treatment of idiopathic pulmonary fibrosis.
    Bioorganic & medicinal chemistry, 2020, 01-15, Volume: 28, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Female; Humans; Idiopathic Pulmonary Fibrosis; Janus Kinase 3; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Molecular Structure; Protein Kinase Inhibitors; Pyrimidines; Structure-Activity Relationship

2020
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections.
    Journal of medicinal chemistry, 2022, 01-27, Volume: 65, Issue:2

    Topics: Antiviral Agents; COVID-19; COVID-19 Drug Treatment; Drug Approval; Drug Repositioning; High-Throughput Screening Assays; Humans; Protein Kinase Inhibitors; SARS-CoV-2; United States; United States Food and Drug Administration; Virus Diseases

2022
Role for ZAP-70 Signaling in the Differential Effector Functions of Rituximab and Obinutuzumab (GA101) in Chronic Lymphocytic Leukemia B Cells.
    Journal of immunology (Baltimore, Md. : 1950), 2017, 08-15, Volume: 199, Issue:4

    Topics: Adenine; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antineoplastic Agents; B-Lymphocytes; Cell Adhesion; Cell Adhesion Molecules; Gefitinib; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Monocytes; Piperidines; Pyrazoles; Pyrimidines; Quinazolines; Receptors, IgG; Rituximab; Signal Transduction; ZAP-70 Protein-Tyrosine Kinase

2017