Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and nvp-aew541

gefitinib has been researched along with nvp-aew541 in 3 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(nvp-aew541)		Trials
(nvp-aew541)		Recent Studies (post-2010) (nvp-aew541)
5,2315662,91995061

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)nvp-aew541 (IC50)
3-phosphoinositide-dependent protein kinase 1Homo sapiens (human)8.9
Epidermal growth factor receptorHomo sapiens (human)5.2
Insulin receptorHomo sapiens (human)0.7885
Tyrosine-protein kinase LckHomo sapiens (human)5.6
Tyrosine-protein kinase LynHomo sapiens (human)1.4
Proto-oncogene tyrosine-protein kinase receptor RetHomo sapiens (human)3.3
Insulin-like growth factor 1 receptorHomo sapiens (human)0.0534
Mast/stem cell growth factor receptor KitHomo sapiens (human)6.3
Fibroblast growth factor receptor 1Homo sapiens (human)4.3
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)4
Platelet-derived growth factor receptor alphaHomo sapiens (human)0.8
Fibroblast growth factor receptor 2Homo sapiens (human)2.7
Fibroblast growth factor receptor 4Homo sapiens (human)5
Vascular endothelial growth factor receptor 2Homo sapiens (human)7.1
Receptor-type tyrosine-protein kinase FLT3Homo sapiens (human)1.4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Homo sapiens (human)3.2
Activin receptor type-1Homo sapiens (human)2.9
Tyrosine-protein kinase BTKHomo sapiens (human)7.6
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.13
Receptor tyrosine-protein kinase erbB-4Homo sapiens (human)1.7

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (33.33)29.6817
2010's2 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bantscheff, M; Bergamini, G; Gohlke, B; Gupta, V; Handa, H; Heinzlmeir, S; Helm, D; Klaeger, S; Kuster, B; Médard, G; Perrin, J; Preissner, R; Qiao, H; Savitski, MM1
Kwan, W; Liu, S; Lubieniecka, JM; Nielsen, TO; Terry, J1
Bubendorf, L; Erne, P; Frachet, A; Frismantiene, A; Kyriakakis, E; Maslova, K; Pfaff, D; Philippova, M; Resink, TJ; Ruiz, C; Vlajnic, T1

Other Studies

3 other study(ies) available for gefitinib and nvp-aew541

ArticleYear
Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors.
    ACS chemical biology, 2016, 05-20, Volume: 11, Issue:5

    Topics: Benzocycloheptenes; Cell Line, Tumor; Ferrochelatase; Heme; Humans; Imidazoles; Indoles; Molecular Docking Simulation; Protein Binding; Protein Kinase Inhibitors; Proteomics; Pyrazines; Pyridines; Quinolines; Sulfonamides; Vemurafenib

2016
Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin prevents synovial sarcoma proliferation via apoptosis in in vitro models.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Aug-01, Volume: 11, Issue:15

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Apoptosis; Benzamides; Benzoquinones; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; ErbB Receptors; Flow Cytometry; Gefitinib; HSP90 Heat-Shock Proteins; Humans; Imatinib Mesylate; Immunoblotting; Immunohistochemistry; In Situ Hybridization, Fluorescence; In Vitro Techniques; Inhibitory Concentration 50; Lactams, Macrocyclic; Piperazines; Prognosis; Pyrimidines; Pyrroles; Quinazolines; Rifabutin; Sarcoma, Synovial; Trastuzumab

2005
EGFR and IGF-1R in regulation of prostate cancer cell phenotype and polarity: opposing functions and modulation by T-cadherin.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2015, Volume: 29, Issue:2

    Topics: Cadherins; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Survival; Collagen; Drug Combinations; ErbB Receptors; Gefitinib; Gene Silencing; Golgi Apparatus; Humans; Laminin; Male; Neoplasm Invasiveness; Phenotype; Phosphorylation; Prostate; Prostatic Neoplasms; Proteoglycans; Pyrimidines; Pyrroles; Quinazolines; Receptor, IGF Type 1

2015