gefitinib and nortriptyline
gefitinib has been researched along with nortriptyline in 6 studies
Compound Research Comparison
Studies (gefitinib) | Trials (gefitinib) | Recent Studies (post-2010) (gefitinib) | Studies (nortriptyline) | Trials (nortriptyline) | Recent Studies (post-2010) (nortriptyline) |
---|---|---|---|---|---|
5,231 | 566 | 2,919 | 2,289 | 517 | 327 |
Protein Interaction Comparison
Protein | Taxonomy | gefitinib (IC50) | nortriptyline (IC50) |
---|---|---|---|
5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.016 | |
Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.0032 | |
Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.347 | |
Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.095 | |
5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.17 | |
Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.027 | |
Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.366 | |
Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | 1.9 | |
Cytochrome P450 2D6 | Homo sapiens (human) | 1.95 | |
Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.082 | |
5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.17 | |
Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.047 | |
Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.1015 | |
5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 1.019 | |
Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.171 | |
D(1A) dopamine receptor | Homo sapiens (human) | 0.539 | |
Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 0.0032 | |
Histamine H2 receptor | Homo sapiens (human) | 2.334 | |
Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.273 | |
5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.051 | |
5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.016 | |
5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 1.019 | |
5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 0.17 | |
5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 0.17 | |
5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.17 | |
5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | 0.17 | |
Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.013 | |
5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | 0.17 | |
Cytochrome P450 2C19 | Homo sapiens (human) | 3 | |
5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | 0.17 | |
5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | 0.17 | |
Histamine H1 receptor | Homo sapiens (human) | 0.05 | |
D(3) dopamine receptor | Homo sapiens (human) | 0.179 | |
5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.17 | |
5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.136 | |
Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 7 | |
5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.554 | |
Voltage-dependent N-type calcium channel subunit alpha-1B | Homo sapiens (human) | 10 | |
Sodium-dependent dopamine transporter | Homo sapiens (human) | 1.678 | |
5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | 0.17 | |
5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.17 |
Research
Studies (6)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (16.67) | 29.6817 |
2010's | 5 (83.33) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Lombardo, F; Obach, RS; Waters, NJ | 1 |
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
Dalvie, D; Loi, CM; Smith, DA | 1 |
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
Reviews
1 review(s) available for gefitinib and nortriptyline
Article | Year |
---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Other Studies
5 other study(ies) available for gefitinib and nortriptyline
Article | Year |
---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Which metabolites circulate?
Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |