Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester

gefitinib has been researched along with n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester in 2 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester)		Trials
(n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester)		Recent Studies (post-2010) (n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester)
5,2315662,9193311239

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester (IC50)
Presenilin-1Homo sapiens (human)0.2071
Presenilin-2Homo sapiens (human)0.2071
Gamma-secretase subunit APH-1BHomo sapiens (human)0.2071
NicastrinHomo sapiens (human)0.2071
Gamma-secretase subunit APH-1AHomo sapiens (human)0.2071
Gamma-secretase subunit PEN-2Homo sapiens (human)0.2071

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dong, Y; Li, A; Michel, LS; Wang, J; Weber, JD1
He, CS; Wei, SH; Xie, M; Zhang, L1

Other Studies

2 other study(ies) available for gefitinib and n-(n-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester

ArticleYear
Synthetic lethality through combined Notch-epidermal growth factor receptor pathway inhibition in basal-like breast cancer.
    Cancer research, 2010, Jul-01, Volume: 70, Issue:13

    Topics: Amyloid Precursor Protein Secretases; Animals; Antineoplastic Agents; Benzodiazepinones; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cell Survival; Dipeptides; Enzyme Activation; ErbB Receptors; Female; Gefitinib; Humans; Mice; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Receptors, Notch; Signal Transduction; Xenograft Model Antitumor Assays

2010
Notch-1 contributes to epidermal growth factor receptor tyrosine kinase inhibitor acquired resistance in non-small cell lung cancer in vitro and in vivo.
    European journal of cancer (Oxford, England : 1990), 2013, Volume: 49, Issue:16

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Dipeptides; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; ErbB Receptors; Female; Gefitinib; Humans; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Protein Kinase Inhibitors; Quinazolines; Receptor, Notch1; RNA Interference; Signal Transduction; Time Factors; Transfection; Xenograft Model Antitumor Assays

2013