Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and marimastat

gefitinib has been researched along with marimastat in 4 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(marimastat)		Trials
(marimastat)		Recent Studies (post-2010) (marimastat)
5,2315662,9192152853

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)marimastat (IC50)
Chain A, A disintegrin and metalloproteinase with thrombospondin motifs 5Homo sapiens (human)0.106
Chain A, Catalytic Domain of ADAMTS-5Homo sapiens (human)0.106
Chain A, A disintegrin and metalloproteinase with thrombospondin motifs 5Homo sapiens (human)0.106
ADAM10Homo sapiens (human)0.0482
disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproproteinHomo sapiens (human)0.0184
Matrix metalloproteinase-20Homo sapiens (human)10
A disintegrin and metalloproteinase with thrombospondin motifs 4Homo sapiens (human)10
Tumor necrosis factorHomo sapiens (human)1.001
Interstitial collagenaseHomo sapiens (human)0.8358
72 kDa type IV collagenaseHomo sapiens (human)0.7167
Stromelysin-1Homo sapiens (human)1.0529
MatrilysinHomo sapiens (human)2.009
Stromelysin-2Homo sapiens (human)10
Cytochrome P450 2C9 Homo sapiens (human)10
Matrix metalloproteinase-9Homo sapiens (human)1.0818
Neutrophil collagenaseHomo sapiens (human)2.0013
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0031
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)10
Macrophage metalloelastaseHomo sapiens (human)5.0025
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0031
Collagenase 3Homo sapiens (human)0.0162
Matrix metalloproteinase-14Homo sapiens (human)3.3345
Matrix metalloproteinase-15Homo sapiens (human)10
Matrix metalloproteinase-16Homo sapiens (human)10
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)5.6679
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)10
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)10
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)10
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)0.0031
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)10
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)10
Matrix metalloproteinase-25Homo sapiens (human)10
Matrix metalloproteinase-26Homo sapiens (human)10
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)10
A disintegrin and metalloproteinase with thrombospondin motifs 5Homo sapiens (human)10
Matrix metalloproteinase-24Homo sapiens (human)10

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Dreymuller, D; Fields, GB; Fridman, R; Giulianotti, M; Golubkov, V; Houghten, RA; Knapinska, AM; LaVoi, TM; Ludwig, A; Minond, D; Smith, L; Sohail, A1
Fukuoka, M1
Yamada, K; Yamaguchi, S; Yamamura, T1

Reviews

2 review(s) available for gefitinib and marimastat

ArticleYear
[Progress in diagnosis and treatment of lung cancer].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2002, Mar-20, Volume: 91 Suppl

    Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Endothelial Growth Factors; Enzyme Inhibitors; Gefitinib; Genetic Therapy; Humans; Hydroxamic Acids; Lung Neoplasms; Lymphokines; Mass Screening; Metalloendopeptidases; Quinazolines; Receptor Protein-Tyrosine Kinases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2002
[Angiogenesis and metastasis in colorectal cancer].
    Nihon rinsho. Japanese journal of clinical medicine, 2003, Volume: 61 Suppl 7

    Topics: Angiopoietin-1; Angiopoietin-2; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Colorectal Neoplasms; Enzyme Inhibitors; Gefitinib; Humans; Hydroxamic Acids; Metalloendopeptidases; Neoplasm Metastasis; Neovascularization, Pathologic; Protein-Tyrosine Kinases; Quinazolines; Vascular Endothelial Growth Factor A

2003

Other Studies

2 other study(ies) available for gefitinib and marimastat

ArticleYear
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes.
    Journal of medicinal chemistry, 2015, Aug-13, Volume: 58, Issue:15

    Topics: ADAM Proteins; ADAM17 Protein; Animals; Cell Line; CHO Cells; Cricetinae; Cricetulus; Humans; In Vitro Techniques; Molecular Probes; Structure-Activity Relationship; Substrate Specificity

2015