Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and ko 143

gefitinib has been researched along with ko 143 in 7 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(ko 143)		Trials
(ko 143)		Recent Studies (post-2010) (ko 143)
5,2315662,91951042

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)ko 143 (IC50)
ATP-dependent translocase ABCB1Homo sapiens (human)0.271
Multidrug resistance-associated protein 1 Homo sapiens (human)4.325
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)0.1882

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (28.57)29.6817
2010's3 (42.86)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Hegedus, T; Kéri, G; Német, K; Orfi, L; Ozvegy-Laczka, C; Sarkadi, B; Schuetz, JD; Ujhelly, O; Váradi, A; Várady, G1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Müller, H; Pick, A; Wiese, M1
Gallus, J; Juvale, K; Wiese, M1
Gallus, J; Krapf, MK; Spindler, A; Wiese, M1
Cai, Z; Ghaleb, H; Huang, W; Jiang, Y; Liu, Y; Qian, H; Qiu, Q; Shi, W; Yin, Z; Zhang, P; Zhou, J; Zou, F1
Delabio, LC; Dutra, JP; Hembecker, M; Kita, DH; Moure, VR; Pereira, GDS; Scheiffer, G; Valdameri, G; Zattoni, IF1

Reviews

1 review(s) available for gefitinib and ko 143

ArticleYear
Targeting breast cancer resistance protein (BCRP/ABCG2): Functional inhibitors and expression modulators.
    European journal of medicinal chemistry, 2022, Jul-05, Volume: 237

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Neoplasm Proteins; Neoplastic Stem Cells

2022

Other Studies

6 other study(ies) available for gefitinib and ko 143

ArticleYear
High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter.
    Molecular pharmacology, 2004, Volume: 65, Issue:6

    Topics: Adenosine Triphosphatases; Animals; Cell Line; Cell Membrane; Drug Resistance, Multiple; Enzyme Inhibitors; HL-60 Cells; Humans; Insecta; Protein-Tyrosine Kinases

2004
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Novel lead for potent inhibitors of breast cancer resistance protein (BCRP).
    Bioorganic & medicinal chemistry letters, 2010, Jan-01, Volume: 20, Issue:1

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Benzimidazoles; Cell Line, Tumor; Chlorophyll; Humans; Molecular Conformation; Neoplasm Proteins; Phenylurea Compounds; Small Molecule Libraries

2010
Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).
    Bioorganic & medicinal chemistry, 2013, Dec-15, Volume: 21, Issue:24

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Humans; Molecular Structure; Neoplasm Proteins; Quinazolines; Structure-Activity Relationship

2013
Synthesis and biological evaluation of quinazoline derivatives - A SAR study of novel inhibitors of ABCG2.
    European journal of medicinal chemistry, 2019, Jan-01, Volume: 161

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Survival; Cells, Cultured; Dogs; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Humans; Molecular Structure; Neoplasm Proteins; Quinazolines; Structure-Activity Relationship

2019
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
    European journal of medicinal chemistry, 2022, Apr-05, Volume: 233

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel

2022