gefitinib has been researched along with geldanamycin in 4 studies
| Studies (gefitinib) | Trials (gefitinib) | Recent Studies (post-2010) (gefitinib) | Studies (geldanamycin) | Trials (geldanamycin) | Recent Studies (post-2010) (geldanamycin) |
|---|---|---|---|---|---|
| 5,231 | 566 | 2,919 | 96 | 0 | 59 |
| 5,231 | 566 | 2,919 | 1,167 | 1 | 329 |
| Protein | Taxonomy | gefitinib (IC50) | geldanamycin (IC50) |
|---|---|---|---|
| Lysine-specific demethylase 6B | Homo sapiens (human) | 0.4 | |
| Lysine-specific demethylase 4B | Homo sapiens (human) | 0.7 | |
| Tyrosine-protein kinase ABL1 | Homo sapiens (human) | 3 | |
| ATP-dependent molecular chaperone HSP82 | Saccharomyces cerevisiae S288C | 3.9667 | |
| Cytochrome P450 1A2 | Homo sapiens (human) | 0.014 | |
| Heat shock protein HSP 90-alpha | Homo sapiens (human) | 0.0917 | |
| Heat shock protein HSP 90-beta | Homo sapiens (human) | 0.098 | |
| Cytochrome P450 3A4 | Homo sapiens (human) | 0.014 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.014 | |
| Breakpoint cluster region protein | Homo sapiens (human) | 3 | |
| Heat shock protein HSP 90 | Oryctolagus cuniculus (rabbit) | 1.141 | |
| Cytochrome P450 2C9 | Homo sapiens (human) | 0.074 | |
| Cytochrome P450 3A5 | Homo sapiens (human) | 0.014 | |
| Cytochrome P450 3A7 | Homo sapiens (human) | 0.014 | |
| Lysine-specific demethylase 5A | Homo sapiens (human) | 0.13 | |
| Cytochrome P450 2C19 | Homo sapiens (human) | 0.074 | |
| Endoplasmin | Canis lupus familiaris (dog) | 0.01 | |
| Heat shock protein 75 kDa, mitochondrial | Homo sapiens (human) | 0.661 | |
| Putative heat shock protein HSP 90-alpha A4 | Homo sapiens (human) | 0.14 | |
| Lysine-specific demethylase 4C | Homo sapiens (human) | 0.7 | |
| Cytochrome P450 3A43 | Homo sapiens (human) | 0.014 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bullock, AN; Fedorov, O; Knapp, S; Marsden, B; Müller, S; Pogacic, V; Rellos, P; Schwaller, J; Sundström, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Basso, A; Chung, EJ; Jung, YJ; Neckers, L; Rosen, N; Trepel, J; Xu, W; Yang, Y; Yuan, X | 1 |
| Bae, MK; Hong, YS; Jang, WJ; Jeong, CH; Jeong, JW; Joo, SH; Jung, SK; Kang, JS; Kundu, JK; Park, GH | 1 |
4 other study(ies) available for gefitinib and geldanamycin
| Article | Year |
|---|---|
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Topics: Amino Acid Sequence; Binding Sites; Clinical Trials as Topic; Drug Evaluation, Preclinical; Enzyme Stability; Humans; Molecular Sequence Data; Phylogeny; Protein Array Analysis; Protein Conformation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases | 2007 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; Benzoquinones; Breast Neoplasms; Cell Line, Tumor; COS Cells; Enzyme Activation; Enzyme Inhibitors; Gefitinib; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Quinazolines; Quinones; Receptor, ErbB-2 | 2003 |
Anti-tumor activity of WK88-1, a novel geldanamycin derivative, in gefitinib-resistant non-small cell lung cancers with Met amplification.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoquinones; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; Gefitinib; Gene Amplification; Humans; Lactams, Macrocyclic; Lung Neoplasms; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Proto-Oncogene Mas; Proto-Oncogene Proteins c-met; Quinazolines; Receptor, ErbB-3 | 2014 |