Compounds > gefitinib
Page last updated: 2024-09-03

gefitinib and epigallocatechin gallate

gefitinib has been researched along with epigallocatechin gallate in 3 studies

Compound Research Comparison

Studies
(gefitinib)		Trials
(gefitinib)		Recent Studies (post-2010)
(gefitinib)		Studies
(epigallocatechin gallate)		Trials
(epigallocatechin gallate)		Recent Studies (post-2010) (epigallocatechin gallate)
5,2315662,9195,4561733,403

Protein Interaction Comparison

ProteinTaxonomygefitinib (IC50)epigallocatechin gallate (IC50)
Chain A, POLYMERASE PAInfluenza A virus1.9
Chain A, Polymerase PaInfluenza A virus (A/California/04/2009(H1N1))1.9
Chain A, Polymerase PaInfluenza A virus (A/California/04/2009(H1N1))1.9
Chain A, Polymerase PaInfluenza A virus (A/California/04/2009(H1N1))1.9
Chain A, Polymerase PaInfluenza A virus (A/California/04/2009(H1N1))1.9
Prostaglandin E synthaseHomo sapiens (human)1.8
Telomerase reverse transcriptaseHomo sapiens (human)1.0867
NAD kinaseHomo sapiens (human)0.96
Urokinase-type plasminogen activatorHomo sapiens (human)0.091
Tissue-type plasminogen activatorHomo sapiens (human)0.091
Polymerase acidic proteinInfluenza A virus (A/Puerto Rico/8/1934(H1N1))5.86
Amyloid-beta precursor proteinHomo sapiens (human)2.7
Plasminogen activator inhibitor 1Homo sapiens (human)0.091
Urokinase-type plasminogen activatorMus musculus (house mouse)0.091
ATP-dependent translocase ABCB1Homo sapiens (human)0.1233
72 kDa type IV collagenaseHomo sapiens (human)4.3833
Hepatocyte growth factor receptorHomo sapiens (human)10
MatrilysinHomo sapiens (human)3.34
Enoyl-[acyl-carrier-protein] reductase [NADH] FabIEscherichia coli K-125
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 21.15
Apoptosis regulator Bcl-2Homo sapiens (human)0.45
Microtubule-associated protein tauHomo sapiens (human)1.8
60 kDa heat shock protein, mitochondrialHomo sapiens (human)2.3
Glucose-6-phosphate 1-dehydrogenaseSaccharomyces cerevisiae S288C0.25
Lethal factorBacillus anthracis0.097
Phosphoglycerate mutase 1Homo sapiens (human)0.49
DNA (cytosine-5)-methyltransferase 1Homo sapiens (human)0.5
Proteasome subunit beta type-5Homo sapiens (human)0.543
DNA repair protein RAD52 homologHomo sapiens (human)2.5108
Matrix metalloproteinase-14Homo sapiens (human)6.8
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6Homo sapiens (human)3.34
Squalene monooxygenase Rattus norvegicus (Norway rat)0.69
6-phosphogluconate dehydrogenase, decarboxylatingHomo sapiens (human)0.72
BH3-interacting domain death agonistHomo sapiens (human)1.0733
Beta-secretase 1Homo sapiens (human)1.1785
10 kDa heat shock protein, mitochondrialHomo sapiens (human)2.3
Bcl-2-like protein 1Homo sapiens (human)0.59
Induced myeloid leukemia cell differentiation protein Mcl-1Homo sapiens (human)0.92
Alpha-(1,3)-fucosyltransferase 7Homo sapiens (human)3.34
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1Homo sapiens (human)3.34
Dual specificity tyrosine-phosphorylation-regulated kinase 1AHomo sapiens (human)0.3055
Mitogen-activated protein kinase 14Homo sapiens (human)2.21
Bcl-2-related protein A1Homo sapiens (human)1.79
Thiosulfate sulfurtransferaseHomo sapiens (human)7.3
60 kDa chaperonin Escherichia coli0.47
Sigma non-opioid intracellular receptor 1Cavia porcellus (domestic guinea pig)10
Dual specificity tyrosine-phosphorylation-regulated kinase 1ARattus norvegicus (Norway rat)0.33
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.73
10 kDa chaperonin Escherichia coli0.47
3-oxoacyl-[acyl-carrier-protein] reductase Plasmodium falciparum 3D70.32
MAP kinase-activated protein kinase 5Homo sapiens (human)1
Bcl-2-like protein 2Homo sapiens (human)2.33
Enoyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)0.225
3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum (malaria parasite P. falciparum)0.3
Beta-hydroxyacyl-ACP dehydratase precursor (Fatty acid synthesis protein)Plasmodium falciparum (malaria parasite P. falciparum)0.215
Bcl-2-like protein 10Homo sapiens (human)0.36

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Amagaya, S; Chang, CM; Chang, PY; Chen, MY; Jao, HY; Kuo, SC; Lee, CY; Lu, CC; Tu, MG; Yang, JS1
Fan, C; Fan, Y; Liang, G; Liu, J; Xu, Y; Yi, P; Zhang, Z; Zhong, T1
Chen, HM; Chen, HY; Chiang, CP; Li, WC; Lin, HY; Wei, YC; Yang, H1

Other Studies

3 other study(ies) available for gefitinib and epigallocatechin gallate

ArticleYear
Epigallocatechin gallate sensitizes CAL-27 human oral squamous cell carcinoma cells to the anti-metastatic effects of gefitinib (Iressa) via synergistic suppression of epidermal growth factor receptor and matrix metalloproteinase-2
    Oncology reports, 2012, Volume: 28, Issue:5

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Catechin; Cell Line, Tumor; Drug Synergism; ErbB Receptors; Extracellular Signal-Regulated MAP Kinases; Gefitinib; Humans; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mouth Neoplasms; Neoplasm Metastasis; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quinazolines; Wound Healing

2012
A new epigallocatechin gallate derivative isolated from Anhua dark tea sensitizes the chemosensitivity of gefitinib via the suppression of PI3K/mTOR and epithelial-mesenchymal transition.
    Fitoterapia, 2020, Volume: 143

    Topics: Apoptosis; Catechin; Cell Line, Tumor; Cell Proliferation; China; Drug Synergism; Epithelial-Mesenchymal Transition; Gefitinib; Humans; Molecular Structure; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phytochemicals; Tea; TOR Serine-Threonine Kinases

2020
Natural Compounds Modulate Drug Transporter Mediated Oral Cancer Treatment.
    Biomolecules, 2020, 09-17, Volume: 10, Issue:9

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Catechin; Cell Line, Tumor; Cell Survival; Curcumin; Gefitinib; Humans; Kaplan-Meier Estimate; Mouth Neoplasms; Neoplasm Proteins; Photochemotherapy; Photosensitizing Agents

2020